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J Indian Soc Pedod Prev Dent 2022 Jan-Mar;40(1):86-89

Department of Paediatric Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Oral swellings and ulcers in neonates are a spectrum of diseases often creating a sense of anxiety among parents. Early detection, high index of suspicion, proper investigations, and prompt diagnosis can aid in accurate management of the same. Lymphangiomas are benign hamartomas which are basically malformed lymphatics do not drain into other lymphatics or veins and hence there is lymphatic accumulation and enlargement following cystically dilated spaces. Read More

J Clin Med 2022 Mar 16;11(6). Epub 2022 Mar 16.

Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland.

Lympangioma cavernosum in the abdominal cavity is a rare benign tumour. In most cases, such tumours are diagnosed in the oral cavity and neck. The aim of this paper is to present our clinical observations and review of existing literature to draw attention to this disease. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;36(3):167-171

Department of Otolaryngology Head and Neck Surgery，Shanghai Children's Hospital，Shanghai Jiao Tong University，Shanghai，200062，China.

To present experience and evaluate the safety and efficacy of surgery combined with bleomycin irrigation for the management of head and neck lymphatic malformations in children. The medical records of all patients with cervical-facial lymphatic malformations who presented to Shanghai Children's Hospital from August 2014 to December 2020 were reviewed. 97 children were divided into surgery group（81 cases） and sclerotherapy group（16 cases）. Read More

Cureus 2022 Jan 9;14(1):e21056. Epub 2022 Jan 9.

Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

Pancreatic lesions are more commonly identified nowadays with the widespread use of imaging investigations. Pancreatic lesions are heterogeneous groups of pathologies with different behavior and prognosis. It is quite difficult to differentiate these lesions because of the shared clinical manifestation and the overlapping imaging features of these lesions. Read More

Front Pharmacol 2021 8;12:668952. Epub 2021 Nov 8.

Department of Pharmacy, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

Sirolimus is an effective oral treatment for pediatric patients with lymphangioma. The present clinical study in 15 children (0.12-16. Read More

Clin Gastroenterol Hepatol 2022 Jun 21;20(6):A17. Epub 2021 Oct 21.

Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.

Head Neck 2021 11 13;43(11):3562-3571. Epub 2021 Sep 13.

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background: To evaluate the frequency and analyze demographic and clinical characteristics of individuals with a histopathological diagnosis of oral lymphatic malformations (OLMs).

Methods: A multicenter study was performed, collecting biopsy record data from a consortium of Brazilian Oral and Maxillofacial Pathology Centers. A review was also conducted to compare this data with cases already available in the literature. Read More

J Contemp Dent Pract 2021 Jun 1;22(6):713-720. Epub 2021 Jun 1.

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, Phone: +81-88-6337356,e-mail:

Aim: To report a treatment case of mandibular deviation caused by congenital cervical lymphangioma with traditional orthodontic techniques, following-up by 10-year retention.

Background: Lymphangiomas, developmental anomalies, can induce various disturbances of swallowing, mastication, speech, breathing, and skeletal deformities as well as psychological stress and anxiety for the patient and their family. Lymphangiomas are benign with virtually no possibility of turning into a malignant lesion, so clinical management aims to treat the patient functionally. Read More

Clin Exp Dermatol 2022 Jan 30;47(1):180-182. Epub 2021 Aug 30.

Departments of Dermatology, Clinical University, Hospital of Santiago de Compostela, A Coruña, Spain.

Lymphangioma is a known, but rare manifestation of Noonan syndrome. We present the case of disseminated and circumscribed cutaneous lymphangiomas in the context of Noonan syndrome. Oral rapamycin is a promising treatment in these extensive and morbidity-causing cases. Read More

Clin Case Rep 2021 Jul 23;9(7):e04537. Epub 2021 Jul 23.

Pediatric and Preventive Dentistry Department Faculty of Dental Medicine of Monastir Monastir Tunisia.

Children with lymphangioma of the tongue may require a close collaboration between physician and dentist to establish preventive, conservative approaches, and eradicate any sources of dental infections before undertaking immunosuppressive therapy. Read More

Oral Maxillofac Surg 2022 Mar 5;26(1):171-176. Epub 2021 Jun 5.

Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, Areão, Piracicaba, São Paulo, Brazil.

We present a challenging case of HIV-related lymphangioma-like Kaposi sarcoma (LLKS) affecting the oral cavity. A 54-year-old Brazilian male patient was referred to our center complaining of bleeding lesions affecting the oral cavity for 2 months. Interestingly, these oral lesions were the first clinical manifestation of HIV infection. Read More

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S81-S83. Epub 2021 Mar 19.

Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Lymphangiomas are benign congenital tumors of the lymphatic system. Tonsillar lymphangiomas are extremely rare. Histopathological confirmation is essential to make the correct diagnosis. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 May;56(5):459-464

Department of Neonatel Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinical features, diagnoses and treatments of head and neck occupying lesions in newborns. All newborns with head and neck occupying lesions admitted to Neonatel Intensive Care Unit of the First Affiliated Hospital of Zhengzhou University form January 2014 to November 2019 were included. There were 23 males and 17 females, admission age was from 2 d-28 d, and the clinical manifestations, examinations, treatments and outcomes were evaluated. Read More

Proc Natl Acad Sci U S A 2021 05;118(19)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan;

Along with blood vessels, lymphatic vessels play an important role in the circulation of body fluid and recruitment of immune cells. Postnatal lymphangiogenesis commonly occurs from preexisting lymphatic vessels by sprouting, which is induced by lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C). However, the key signals and cell types that stimulate pathological lymphangiogenesis, such as human cystic lymphangioma, are less well known. Read More

J Korean Assoc Oral Maxillofac Surg 2021 Apr;47(2):145-148

Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Athens, Athens, Greece.

Minor salivary gland sialolithiasis (MSGS) is a not uncommon oral mucosal disease. Its clinical appearance may mimic a mucocyst or other benign submucosal overgrowth. Stasis of saliva, which accompanies MSGS, usually results in minor salivary gland inflammation, with a chronic sialadenitis appearance. Read More

J Ultrasound Med 2022 Mar 26;41(3):597-604. Epub 2021 Apr 26.

Department of Medical Ultrasonic, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Objectives: To analyze the imaging manifestations of common fetal oral masses by ultrasound combined with magnetic resonance imaging (MRI) and to discuss their differential diagnoses.

Methods: A retrospective study of 6 fetuses with oral masses was performed at a tertiary referral center. The imaging features of prenatal ultrasonography and MRI in the diagnosis of fetal oral masses were analyzed. Read More

Cureus 2021 Jan 27;13(1):e12929. Epub 2021 Jan 27.

Oral and Maxillofacial Surgery, Rotherham National Health Service Foundation Trust, Rotherham, GBR.

Administration of hyaluronic acid (HA) filler for aesthetic lip augmentation is a routine and common procedure with a low rate of adverse reactions. This case report documents an extremely rare complication of lip augmentation with HA leading to the development of lymphangiomas. Lymphangiomas are uncommon hamartomas of the lymphatic system. Read More

Acta Medica (Hradec Kralove) 2021 ;64(4):224-226

Department of Oral and Maxillofacial Surgery, General Hospital of Tripolis "Evangelistria", Greece.

Cystic lymphangioma (CL) is a rare benign tumour that arises from the lymphatic vessels. The most common site of presentation is the posterior triangle of the neck. 90% of the lesions are diagnosed before the age of two years old and only a small number is reported in adults. Read More

Int J Oral Maxillofac Surg 2021 May 12;50(5):619-626. Epub 2020 Oct 12.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Intralesional sclerotherapy for lymphatic malformations (LMs) has become a modality of choice because of the high morbidity and recurrence rates with surgical excision. Traditionally, the macrocystic variant has shown good results with sclerotherapy. This prospective study was performed to evaluate the role of bleomycin sclerotherapy in the management of different radiological variants of LM. Read More

Rev Med Liege 2020 Jul;75(7-8):541-543

Service de Chirurgie cardiovasculaire, CHU Liège, Belgique.

Cystic lymphangioma is a rare and benign lymphatic malformation found most often in the first two years of life. Clinical manifestations are diverse and depend on size and site of the lesion. The most frequently affected sites are cervicofacial and axillary areas. Read More

Ear Nose Throat J 2021 Dec 24;100(10_suppl):1076S-1078S. Epub 2020 Jun 24.

Department of Plastic and Reconstructive Surgery, Yokohama City University Hospital, Yokohama, Kanagawa, Japan.

Oral Maxillofac Surg 2020 09 13;24(3):371-372. Epub 2020 Jun 13.

The Vascular Birthmark Foundation, VBF Europe, VBF Italy, PO Box 106, Latham, NY, 12110, USA.

Oral Maxillofac Surg 2020 Sep 12;24(3):383-385. Epub 2020 Jun 12.

Division of Otolaryngology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara, Italy.

In this reply to a letter, the Authors discuss the raised points regarding the nomenclature and management of Lymphatic Malformations / Lymphangiomas. Read More

Dermatol Ther 2020 07 14;33(4):e13463. Epub 2020 May 14.

Department of Special Patient Care, Hospital Dentistry Clinic, UCLA School of Dentistry, Los Angeles, California, USA.

Lymphangioma circumscriptum is a benign lymphatic malformation that usually presents at birth or early childhood. Acquired oral lymphangioma has been reported secondary to radiation therapy and denture-induced trauma due to damage to previously normal lymphatics. To the best of our knowledge, this is the first report of acquired oral lymphangioma due to childhood tuberculous adenitis. Read More

World J Gastroenterol 2020 Apr;26(13):1540-1545

Department of Gastroenterology, Air Force Medical Center, Beijing 100142, China.

Background: Hemolymphangiomas are rare malformations composed of both lymphatic and vascular vessels and are located in the pancreas, spleen, mediastinum, . Small intestinal hemolymphangioma is extremely rare and often presents as obscure gastrointestinal bleeding. It is rarely diagnosed correctly before the operation. Read More

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):230

Department of Dermatology, Topiwala National Medical College and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India.

The incidence of lymphangioma is 1.2 to 2.8/1000 newborns. Read More

Oral Maxillofac Surg 2020 Mar 20;24(1):109-115. Epub 2020 Jan 20.

ENT Division, University Hospital "Maggiore della Carità", University of Eastern Piedmont, Novara, Italy.

Introduction: Lymphangiomas are relatively uncommon head and neck region lymphatic malformations. Although surgery can be still considered the mainstay of treatment, sclerotherapy by OK-432 is becoming a widespread treatment option. The aim of this article is to present and discuss the management and outcomes of a series of cases of lymphangiomas. Read More

Eur J Paediatr Dent 2019 Dec;20(4):311-314

Fondazione IRCCS Ca'Granda, Ospedale Maggiore Policlinico, Milan - University of Milan, Milan, Italy.

Background: Lymphangioma of the tongue is a rare condition related to congenital malformations of the lymphatic system. It may have different implications such as macroglossia. This condition could exacerbate in aesthetic abnormalities and functional problems such as maxillofacial structural deformities, dysphagia, airway obstruction and speech difficulties. Read More

Head Neck Pathol 2020 Jun 10;14(2):512-515. Epub 2019 Dec 10.

Tuanku Mizan Armed Forces Hospital, Kuala Lumpur, Malaysia.

Lymphangiomas are rare, congenital malformations of the lymphatic system which have a marked predilection for the head and neck. In this region, they most commonly occur on the dorsum of the tongue, followed by the lips, buccal mucosa, soft palate, and floor of the mouth. Lymphangiomas of the tongue are commonly present at birth; however, they may go unnoticed until after eruption of the dentition or even puberty. Read More

Sultan Qaboos Univ Med J 2019 Aug 5;19(3):e257-e261. Epub 2019 Nov 5.

Department of Pathology, Chacha Nehru Bal Chikitsalya, Delhi, India.

Foregut cystic developmental malformations (FCDM) are a type of rare cystic lesion. The occurrence of FCDM is exceedingly uncommon in the intraoral location. We report three cases of FCDM with intraoral location who presented at Chacha Nehru Bal Chikitsalaya, New Delhi, India, in 2016, 2017 and 2018 with symptoms of respiratory distress and feeding difficulties. Read More