486 results match your criteria Oral Lymphangiomas


Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.

Proc Natl Acad Sci U S A 2021 May;118(19)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan;

Along with blood vessels, lymphatic vessels play an important role in the circulation of body fluid and recruitment of immune cells. Postnatal lymphangiogenesis commonly occurs from preexisting lymphatic vessels by sprouting, which is induced by lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C). However, the key signals and cell types that stimulate pathological lymphangiogenesis, such as human cystic lymphangioma, are less well known. Read More

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Sialolithiasis of minor salivary gland: a challenging diagnostic dilemma.

J Korean Assoc Oral Maxillofac Surg 2021 Apr;47(2):145-148

Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Athens, Athens, Greece.

Minor salivary gland sialolithiasis (MSGS) is a not uncommon oral mucosal disease. Its clinical appearance may mimic a mucocyst or other benign submucosal overgrowth. Stasis of saliva, which accompanies MSGS, usually results in minor salivary gland inflammation, with a chronic sialadenitis appearance. Read More

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Prenatal Diagnosis of Fetal Oral Masses by Ultrasound Combined With Magnetic Resonance Imaging.

J Ultrasound Med 2021 Apr 26. Epub 2021 Apr 26.

Department of Medical Ultrasonic, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Objectives: To analyze the imaging manifestations of common fetal oral masses by ultrasound combined with magnetic resonance imaging (MRI) and to discuss their differential diagnoses.

Methods: A retrospective study of 6 fetuses with oral masses was performed at a tertiary referral center. The imaging features of prenatal ultrasonography and MRI in the diagnosis of fetal oral masses were analyzed. Read More

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Lymphangioma Formation Following Hyaluronic Acid Injection for Lip Augmentation.

Cureus 2021 Jan 27;13(1):e12929. Epub 2021 Jan 27.

Oral and Maxillofacial Surgery, Rotherham National Health Service Foundation Trust, Rotherham, GBR.

Administration of hyaluronic acid (HA) filler for aesthetic lip augmentation is a routine and common procedure with a low rate of adverse reactions. This case report documents an extremely rare complication of lip augmentation with HA leading to the development of lymphangiomas. Lymphangiomas are uncommon hamartomas of the lymphatic system. Read More

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January 2021

Bleomycin sclerotherapy in lymphangiomas of the head and neck region: a prospective study.

Int J Oral Maxillofac Surg 2021 May 12;50(5):619-626. Epub 2020 Oct 12.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Intralesional sclerotherapy for lymphatic malformations (LMs) has become a modality of choice because of the high morbidity and recurrence rates with surgical excision. Traditionally, the macrocystic variant has shown good results with sclerotherapy. This prospective study was performed to evaluate the role of bleomycin sclerotherapy in the management of different radiological variants of LM. Read More

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[Retroperitoneal cystic lymphangioma treated by sildenafil].

Rev Med Liege 2020 Jul;75(7-8):541-543

Service de Chirurgie cardiovasculaire, CHU Liège, Belgique.

Cystic lymphangioma is a rare and benign lymphatic malformation found most often in the first two years of life. Clinical manifestations are diverse and depend on size and site of the lesion. The most frequently affected sites are cervicofacial and axillary areas. Read More

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Don't call me "Lymphangioma!"

Oral Maxillofac Surg 2020 09 13;24(3):371-372. Epub 2020 Jun 13.

The Vascular Birthmark Foundation, VBF Europe, VBF Italy, PO Box 106, Latham, NY, 12110, USA.

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September 2020

The various meanings and imperfections of words.

Oral Maxillofac Surg 2020 Sep 12;24(3):383-385. Epub 2020 Jun 12.

Division of Otolaryngology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara, Italy.

In this reply to a letter, the Authors discuss the raised points regarding the nomenclature and management of Lymphatic Malformations / Lymphangiomas. Read More

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September 2020

Acquired lymphangioma circumscriptum secondary to tuberculosis: A rare case report.

Dermatol Ther 2020 07 14;33(4):e13463. Epub 2020 May 14.

Department of Special Patient Care, Hospital Dentistry Clinic, UCLA School of Dentistry, Los Angeles, California, USA.

Lymphangioma circumscriptum is a benign lymphatic malformation that usually presents at birth or early childhood. Acquired oral lymphangioma has been reported secondary to radiation therapy and denture-induced trauma due to damage to previously normal lymphatics. To the best of our knowledge, this is the first report of acquired oral lymphangioma due to childhood tuberculous adenitis. Read More

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Small intestinal hemolymphangioma treated with enteroscopic injection sclerotherapy: A case report and review of literature.

World J Gastroenterol 2020 Apr;26(13):1540-1545

Department of Gastroenterology, Air Force Medical Center, Beijing 100142, China.

Background: Hemolymphangiomas are rare malformations composed of both lymphatic and vascular vessels and are located in the pancreas, spleen, mediastinum, . Small intestinal hemolymphangioma is extremely rare and often presents as obscure gastrointestinal bleeding. It is rarely diagnosed correctly before the operation. Read More

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Lymphangiomas: Rare presentations in oral cavity and scrotum in pediatric age group.

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):230

Department of Dermatology, Topiwala National Medical College and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India.

The incidence of lymphangioma is 1.2 to 2.8/1000 newborns. Read More

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November 2020

A single-center experience in the management of head and neck lymphangiomas.

Oral Maxillofac Surg 2020 Mar 20;24(1):109-115. Epub 2020 Jan 20.

ENT Division, University Hospital "Maggiore della Carità", University of Eastern Piedmont, Novara, Italy.

Introduction: Lymphangiomas are relatively uncommon head and neck region lymphatic malformations. Although surgery can be still considered the mainstay of treatment, sclerotherapy by OK-432 is becoming a widespread treatment option. The aim of this article is to present and discuss the management and outcomes of a series of cases of lymphangiomas. Read More

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Lymphangioma of the tongue associated with open bite: case report.

Eur J Paediatr Dent 2019 Dec;20(4):311-314

Fondazione IRCCS Ca'Granda, Ospedale Maggiore Policlinico, Milan - University of Milan, Milan, Italy.

Background: Lymphangioma of the tongue is a rare condition related to congenital malformations of the lymphatic system. It may have different implications such as macroglossia. This condition could exacerbate in aesthetic abnormalities and functional problems such as maxillofacial structural deformities, dysphagia, airway obstruction and speech difficulties. Read More

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December 2019

Lymphangioma of the Dorsal Tongue.

Head Neck Pathol 2020 Jun 10;14(2):512-515. Epub 2019 Dec 10.

Tuanku Mizan Armed Forces Hospital, Kuala Lumpur, Malaysia.

Lymphangiomas are rare, congenital malformations of the lymphatic system which have a marked predilection for the head and neck. In this region, they most commonly occur on the dorsum of the tongue, followed by the lips, buccal mucosa, soft palate, and floor of the mouth. Lymphangiomas of the tongue are commonly present at birth; however, they may go unnoticed until after eruption of the dentition or even puberty. Read More

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Intraoral Foregut Cystic Developmental Malformations: Three cases with a brief review of literature.

Sultan Qaboos Univ Med J 2019 Aug 5;19(3):e257-e261. Epub 2019 Nov 5.

Department of Pathology, Chacha Nehru Bal Chikitsalya, Delhi, India.

Foregut cystic developmental malformations (FCDM) are a type of rare cystic lesion. The occurrence of FCDM is exceedingly uncommon in the intraoral location. We report three cases of FCDM with intraoral location who presented at Chacha Nehru Bal Chikitsalaya, New Delhi, India, in 2016, 2017 and 2018 with symptoms of respiratory distress and feeding difficulties. Read More

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Development of a biomarker of efficacy in second-line treatment for lymphangioma of the tongue: a pilot study.

Br J Oral Maxillofac Surg 2019 12 12;57(10):1137-1142. Epub 2019 Nov 12.

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University. Electronic address:

Lymphangioma of the tongue is a rare lymphatic malformation, and various authors have reported the successful use of sirolimus for its treatment. However, the safety of sirolimus in children needs further evaluation so that those who do not respond are not necessarily exposed to its potential adverse effects. We hypothesised that assessment of lymphangiogenesis can be used to predict whether the patient will respond to sirolimus, so we organised a prospective study after ethics committee approval had been given. Read More

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December 2019

Reduction glossectomy of congenital macroglossia due to lymphangioma.

Arch Craniofac Surg 2019 Oct 20;20(5):314-318. Epub 2019 Oct 20.

Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Macroglossia is a rare clinical condition defined as an enlarged tongue. Macroglossia can cause structural deformities like diastema and disproportionate mandibular growth and present functional disorders such as dysarthria, dysphonia, and respiratory problems. A 7-year-old boy who had lymphangiomatous macroglossia was treated with a reduction glossectomy by anchor-shaped combination of a U-shape and modified key-hole resection. Read More

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October 2019

Cystic lymphangioma in the peripheral jejunal mesentery in an adult and excision with laparoscopic-assisted surgery: a case report.

World J Surg Oncol 2019 Oct 24;17(1):170. Epub 2019 Oct 24.

Department of Human Pathology Kanazawa University Graduate School of Medicine, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.

Background: Lymphangiomas are uncommon congenital malformations that present mainly in the head, neck, and axillar regions in pediatric patients. Mesenteric cystic lymphangiomas (MCLs), which occasionally present with substantial growth and the invasion of adjacent vital structures, are rarely reported in adults. We report a case of MCL in an adult who was treated with laparoscopic-assisted excision. Read More

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October 2019

Lymphangioma in the Buccal Mucosa.

J Craniofac Surg 2019 Nov-Dec;30(8):e696-e697

Assistant Professor, Izmir Katip Çelebi University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Turkey.

Lymphangiomas are benign hamartomatous tumors which are characterized by abnormal proliferation of lymphatic vessels. They are lymphatic malformations which are commonly localized to head and neck region. They are rare located in the oral cavity and tongue, lips, buccal mucosa, soft palate, floor of the mouth are mostly affected. Read More

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January 2020

Congenital lymphangioma circumscriptum of the vulva.

J Obstet Gynaecol Res 2019 Oct 30;45(10):2137-2138. Epub 2019 Jul 30.

Department of Obstetrics and Gynecology, Royal Preston Hospital, Preston, UK.

Lymphangioma circumscriptum is a rare benign disorder of unknown etiology affecting lymph vessels in the deep dermal and subcutaneous layers. The commonest sites of presentation are the axilla, shoulders, groins, tongue and oral cavity. Lymphangioma circumscriptum of the vulva is very rare can be either congenital or secondary to lymphadenectomy or pelvic radiation in patients with genital cancer, genital tuberculosis, Crohn's disease, cellulitis, morbid obesity and immobilization. Read More

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October 2019

Neck masses in children: a 10-year single-centre experience in Northwest China.

Br J Oral Maxillofac Surg 2019 10 30;57(8):729-733. Epub 2019 Jun 30.

Department of Oral and Maxillofacial Surgery, Lanzhou University Second Hospital, Lanzhou, China. Electronic address:

Neck masses in children are a common clinical concern but there is a paucity of published information about them. We organised this retrospective study to analyse their prevalence and treatment in Northwest China. The records of 207 children who presented with neck masses between 2008 and 2017 were retrieved from the Department of Oral and Maxillofacial Surgery, Lanzhou University Second Hospital, and age, sex, clinical presentation, preoperative investigation, surgical procedure, histopathological diagnosis, and complications were recorded. Read More

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October 2019

Medical and sclerosing agents in the treatment of orbital lymphatic malformations: what's new?

Curr Opin Ophthalmol 2019 Sep;30(5):380-385

Hong Kong Eye Hospital, Hong Kong Special Administrative Region.

Purpose Of Review: Currently, there is no ideal management for orbital lymphatic malformations. Significant advances have been made since the discovery of new agents in the treatment. The purpose of this manuscript is to review the recent evidence on new sclerotherapy agents and systemic medications. Read More

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September 2019

[Lymphangioma of the penis].

Urologiia 2019 Jun(2):64-66

) Ural scientific research Institute of dermatology and immunopathology. Ekaterinburg, Russia.

Lymphangioma circumscriptum (LC) is a rare, benign condition, predominantly characterized by the malformation of lymphatic skin vessels. The most common sites include the oral mucosa, tongue, skin of the extremities and torso. Lymphangioma of the penis is rare disease. Read More

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Lymphangioma circumscriptum of glans penis: a report of two cases.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Naja Clinic, Department of Dermatology, Gilan, Rasht.

Lymphangioma circumscriptum is a developmental anomaly of lymphatic vessels, which appear as aggregates of clear or hemorrhagic vesicles on the skin or mouth. Glans penis involvement is very uncommon. Because of the sensitivity of the area, possible functional, cosmetic, or psychologic disturbances can result. Read More

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Splenic cystic lymphangiomatosis in association with omental varices and portal hypertension: A case report.

Medicine (Baltimore) 2018 Oct;97(40):e12552

Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital.

Rational: Lymphangiomatosis is rare and benign, and slowly proliferating lymphatic vessels of unknown etiology and visceral lymphangiomatosis involving the spleen is rare. Since lymphangiomatosis may be asymptomatic or present as a sense of fullness, splenic cystic lymphangiomatosis is a disease of little concern.

Patient Concerns: A 34-year-old woman suffering from progressive epigastric fullness after oral intake for two weeks. Read More

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October 2018

A case of microcystic lymphatic malformation successfully treated with topical sirolimus.

Dermatol Ther 2018 09 22;31(5):e12673. Epub 2018 Aug 22.

Gulhane Medical Faculty, Department of Dermatology, University of Health Sciences, Ankara, Turkey.

Microcystic lymphatic malformation (MLM), also known as "lymphangioma circumscriptum," is a lymphatic malformation which may involve the skin and subcutaneous tissues. Progressive growth of lesions may cause pressure to the surrounding organs. Lesions frequently reoccur after treatment with surgery, sclerotherapy, radiotherapy, and laser therapy. Read More

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September 2018

[The superficial circumscribed lymphangioma of the tongue].

Pan Afr Med J 2018 6;29:202. Epub 2018 Apr 6.

Service de Dermatologie, CHU Hassan II, Fes, Maroc.

Superficial circumscribed lymphangiomas are predominantly benign lesions occuring in the cervicofacial area. These malformations of the lymphatic vessels are frequently diagnosed in children. We report the clinical case of lymphangioma of the tongue that occurred in an old man. Read More

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Small bowel lymphangioma causing ileo-ileal intussusception in adults.

Int J Surg Case Rep 2017 21;41:469-472. Epub 2017 Nov 21.

Department of Surgery, Montefiore New Rochelle Hospital, New York, USA.

Introduction: Lymphangioma is a rare benign tumor found in gastrointestinal tract. Most lymphangiomas can occur at any age and but mostly are found in children and infants. They are mainly due to malformation of the lymphatic system. Read More

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November 2017

Lymphangioma Of Tongue.

J Ayub Med Coll Abbottabad 2018 Jan-Mar;30(1):146

Department of Dentistry, S.P Medical College Bikaner, India.

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Oral lymphangiomas - clinical and histopathological relations: An immunohistochemically analyzed case series of varied clinical presentations.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S108-S111

Department of Oral Pathology and Microbiology, Sarjug Dental College, Darbhanga, Bihar, India.

Lymphangiomas are benign malformations that represent hamartoma of malformed lymphatics and are composed of cystically dilated lymphatic channels which do not communicate or drain into other lymphatic channels or veins leading to accumulation of lymph. They are congenital malformations with rare occurrence in oral cavity within which tongue dorsum is the most affected site. Venous malformations are often difficult to differentiate from lymphatic malformations leading to the development of several lymphatic markers like D2-40 which seems to be useful for distinguishing vascular from lymphatic vessels. Read More

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January 2018