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    Oral Lichen Planus: A Cross-Sectional/Descriptive Study of 33 Patients.
    Skinmed 2017 1;15(5):333-337. Epub 2017 Oct 1.
    Department of Conservative Dentistry and Endodontics, Government Dental College, Raipur, India.
    Oral lichen planus (OLP), a well-known entity, is often neglected; however, its assessment is considered essential for evolving future strategies for treatment. Thirty-three patients with OLP from 200 consecutive patients with oral mucosal lesions were studied according to demography. Tobacco chewing, smoking, and alcohol intake were recorded. Read More

    Prevalence of oral lichen planus in Iranian children and adolescents: a 12-year retrospective study.
    Eur Arch Paediatr Dent 2017 Nov 14. Epub 2017 Nov 14.
    Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Aim: To investigate the prevalence of oral lichen planus in patients younger than 18 years, referred to a dermatology centre in Iran during 2002-2014. Lichen planus is a chronic inflammatory, immune-mediated disease that could affect the oral mucosa and is a pre-cancerous condition. The disease usually develops in middle age with female predominance and is rare in children. Read More

    Reduced miRNA‑214 expression in oral mucosa contributes to the pathogenesis of oral lichen planus by targeting CD44.
    Mol Med Rep 2017 Nov 10. Epub 2017 Nov 10.
    Department of Prosthodontics, Jining Hospital of Stomatology, Jining, Shandong 272001, P.R. China.
    The present study aimed to investigate the role of miRNAs during the pathogenesis of oral lichen planus (OLP). OLP is a chronic inflammatory disorder, which involves T‑cell mediated autoimmunity and affects the skin, scalp, nails and mucosa. Abundant T lymphocytes have been demonstrated to infiltrate the oral mucosa, in which the activated T cells trigger apoptosis of oral epithelial cells. Read More

    Expression and role of p53 in oral lichen planus patients.
    J BUON 2017 Sep-Oct;22(5):1278-1286
    Clinic of Periodontology and Oral Medicine, Faculty of Dentistry, University of Belgrade, Belgrade, Serbia.
    Purpose: Oral lichen planus (OLP) is an autoimmune skin and mucosal disorder. The range of malignant transformation in OLP varies between 0.1-3%. Read More

    Alteration of salivary glycopatterns in oral lichen planus.
    Biomarkers 2017 Nov 13:1-21. Epub 2017 Nov 13.
    a Department of Immunology , the Fourth Military Medical University , Xi'an , 710032 , China.
    Background: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Read More

    A prospective observational study to compare efficacy of topical triamcinolone acetonide 0.1% oral paste, oral methotrexate, and a combination of topical triamcinolone acetonide 0.1% and oral methotrexate in moderate to severe oral lichen planus.
    Dermatol Ther 2017 Nov 10. Epub 2017 Nov 10.
    Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Topical corticosteroids are considered to be the most effective treatment for oral lichen planus (OLP). Methotrexate has been found to be effective in extensive cutaneous lichen planus. The objectives of the study were to evaluate the clinical efficacy and safety of topical triamcinolone 0. Read More

    Management of Oral Lichen Planus by 980 nm Diode Laser.
    J Lasers Med Sci 2017 27;8(3):150-154. Epub 2017 Jun 27.
    Laser Research Center of Dentistry, Dental Research Institute, Tehran University of Medial Sciences, Tehran, Iran.
    Introduction: Oral lichen planus (OLP) is a mucocutaneous disease with uncertain etiology. As the etiology is unknown standard treatment modalities are not available. The traditional and common treatment relies on corticosteroids whether topical or systemic. Read More

    Outcomes of oral lichen planus and oral lichenoid lesions treated with topical corticosteroid.
    Oral Dis 2017 Nov 9. Epub 2017 Nov 9.
    School of Dentistry. Instituto de Biomedicina de Granada, University of Granada, Spain.
    Objective: To determine corticosteroid treatment effectiveness in patients with Oral Lichen Planus/Oral Lichenoid Lesions (OLP/OLL).

    Material And Methods: Twenty-one OLP and eighty-one OLL patients received 0.05% clobetasol propionate (CP) or 0. Read More

    Looking Beyond the Cyclosporine "Swish and Spit" Technique in a Recalcitrant Case of Erosive Lichen Planus Involving the Tongue.
    Case Rep Dermatol 2017 Sep-Dec;9(3):177-183. Epub 2017 Oct 3.
    Postgraduate Institute of Medical Education and Research (PGIMER), Delhi, India.
    Oral lichen planus is a relatively common autoimmune disease affecting the middle-aged population. Although no treatment is necessary for a benign asymptomatic case, in case of erosive lichen planus, topical corticosteroids form the mainstay of treatment. In case of failure, apart from tacrolimus, cyclosporine, using the "swish and spit" technique, is a valid therapeutic intervention. Read More

    Oral Lichen Planus in a Pediatric Patient: A Novel Therapeutic Approach.
    J Dent (Tehran) 2017 Mar;14(2):109-114
    Professor, Department of Oral Medicine and Radiology, P.D.M. Dental College, Bahadurgarh, Haryana, India.
    Lichen planus is a mucocutaneous disease, predominantly affecting the middle-aged individuals and may be associated with a plethora of signs and symptoms related to the skin, scalp, nails and mucous membranes. The definitive etiology of lichen planus is not yet known and no therapeutic modality has yet been universally accepted. Lichen planus in pediatric patients is a rare phenomenon and its presence in the oral mucosa is even rarer. Read More

    Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists.
    Endocr Connect 2017 Nov;6(8):726-730
    Department of Surgical SciencesCIR-Dental School, University of Turin, Turin, Italy.
    The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Read More

    Porphyromonas gingivalis lipopolysaccharide induces over production of CC chemokine ligand 2 via toll-like receptor-4 in oral lichen planus.
    J Oral Pathol Med 2017 Oct 23. Epub 2017 Oct 23.
    Department of Oral Medicine, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
    Background: We recently reported that the CC chemokine ligand 2 (CCL2)-CC receptor 2 (CCR2) axis was involved in the pathogenesis of oral lichen planus (OLP). However, the exact mechanism for the high expression of CCL2 in OLP specimens is not clear. Therefore, this study was designed to investigate the potential role of the toll-like receptor 4 (TLR-4) pathway in overproduction of CCL2 in OLP lesions. Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    Correlation between tissue expression of microRNA-137 and CD8 in oral lichen planus.
    Clin Oral Investig 2017 Oct 15. Epub 2017 Oct 15.
    Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
    Objectives: Oral lichen planus (OLP) is a chronic, inflammatory condition, classified by the World Health Organization as a premalignant lesion. We performed this study to evaluate the correlation between microRNA-137 (miR-137) and CD8 oral tissue expression in OLP patients.

    Materials And Methods: Twenty OLP patients [classified into three groups: (a) papular, reticular, or plaque; (b) atrophic; and (c) erosive] and 20 healthy controls were subjected to biopsy of the oral mucosa. Read More

    Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
    J Am Acad Dermatol 2017 Nov;77(5):809-830
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    The oral cavity and cutaneous organ systems share a close embryologic origin. Therefore, there are numerous dermatologic conditions presenting with concomitant oral findings of which the dermatologist must be aware. The second article in this continuing medical education series reviews inflammatory orocutaneous conditions and a number of genodermatoses. Read More

    A Japanese Case of Esophageal Lichen Planus that Was Successfully Treated with Systemic Corticosteroids.
    Intern Med 2017 Oct 11. Epub 2017 Oct 11.
    Department of Internal Medicine, Tsuyama Chuo Hospital, Japan.
    Esophageal lichen planus (ELP) is rare and only about 80 cases have been reported in the literature. An 85-year-old woman presented with dysphagia and odynophagia. Endoscopy revealed a severe stricture in the proximal esophagus. Read More

    Ultrastructural Changes during the Life Cycle of Mycoplasma salivarium in Oral Biopsies from Patients with Oral Leukoplakia.
    Front Cell Infect Microbiol 2017 21;7:403. Epub 2017 Sep 21.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical UniversityShiwagun, Japan.
    Bacteria in genus Mycoplasma spp. are the smallest and simplest form of freely replicating bacteria, with 16 species known to infect humans. In the mouth, M. Read More

    DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus.
    J Oral Pathol Med 2017 Oct 4. Epub 2017 Oct 4.
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
    Background: The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. Read More

    Role of Cathepsin B as a Marker of Malignant Transformation in Oral Lichen Planus: An Immunohistochemical Study.
    J Clin Diagn Res 2017 Aug 1;11(8):ZC29-ZC32. Epub 2017 Aug 1.
    Reader, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
    Introduction: Malignant transformation of Oral Lichen Planus (OLP) remains a much discussed but very less understood realm. Various hypotheses and theories have been put forward to explain the same. Malignant transformation is a complex interplay of epithelial mesenchymal factors acting in tandem. Read More

    [Oral cancer -diagnosis and therapy-.]
    Clin Calcium 2017;27(10):1427-1433
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Japan.
    Oral cancer is a malignant neoplasm that occurs in the oral cavity. Squamous cell carcinoma accounts for over 90%of the oral cancers, and others include adenocarcinoma derived from minor salivary gland, sarcoma, malignant lymphoma and metastatic cancer. The number of oral cancer patients in Japan is about 3-times higher than the current number. Read More

    Lichen Planus triggered by infliximab biosimilar CT-P13 and recurred during secukinumab treatment.
    Br J Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Dermatology Unit, Department of Surgical and Translational Medicine, University of Florence.
    we read with interest the manuscript published by Gonzales et al,(1) highlighting lichenoid reactions as an emerging side effect of biologics, with special regard to infliximab-biosimilar. We recently observed a 50-year-old male patient with a long-standing history of moderate-to-severe psoriasis, who developed oral lichen planus (LP) triggered by infliximab biosimilar CT-P13. Interestingly the same patient experienced cutaneous and oral LP when treated with IL-17A blocker, secukinumab. Read More

    Mucin 5B in saliva and serum of patients with oral lichen planus.
    Sci Rep 2017 Sep 21;7(1):12060. Epub 2017 Sep 21.
    Dental Research Center, Dentistry Research Institute, Department of Oral and Maxillofacial Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Oral lichen planus (OLP) is among the most common oral diseases. Its etiopathogenesis has yet to be clearly identified. OLP patients complain of mouth dryness. Read More

    Validation of immunoexpression of tenascin-C in oral precancerous and cancerous tissues using ImageJ analysis with novel immunohistochemistry profiler plugin: An immunohistochemical quantitative analysis.
    J Oral Maxillofac Pathol 2017 May-Aug;21(2):211-217
    Department of Oral Pathology and Microbiology, KLE University, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
    Background: Immunohistochemistry (IHC) is a molecular technique that has grown tremendously over the years. However, the assessment is only qualitative which is subjective and causes errors. Due to this limitation, several excellent markers have not gained importance and reached clinical trials. Read More

    Linear Lichen Planus: Continuum From Skin to Mucosa.
    J Cutan Med Surg 2017 Sep 1:1203475417733463. Epub 2017 Sep 1.
    1 Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India.
    Lichen planus (LP) is a chronic inflammatory disorder that most commonly affects middle-aged individuals. LP involves the skin and/or mucous membranes, including oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. Linear LP, a rare distinct variant of LP, is characterised by pruritic eruption of lichenoid and violaceous papules in a linear distribution. Read More

    Drug-induced oral lichenoid reactions: a real clinical entity? A systematic review.
    Eur J Clin Pharmacol 2017 Dec 13;73(12):1523-1537. Epub 2017 Sep 13.
    Department of Libraries, New Orleans School of Dentistry, Louisiana State University Health Sciences Center, 1100 Florida Ave, New Orleans, LA, 70119, USA.
    Purpose: Drug-induced oral lichenoid reactions (DIOLRs) have been extensively reported in the literature, but the validity of the causality relationship between any drug and the oral lichenoid lesions (OLLs) still remains questionable. We sought to determine whether this causality relationship really exists, whether a resolution of the oral lesions upon withdrawal occurs, and what the most common alleged offending medications are.

    Methods: Nine electronic databases from January 1966 to December 2016 were systematically searched to identify all relevant studies selected with specific inclusion criteria (a clinical and histopathological diagnosis of DIOLRs, and clearly statement on the systemic offending medication). Read More

    Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus.
    J Oral Sci 2017 ;59(3):373-382
    Eastman Dental Institute, University College London.
    Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing body of evidence regarding the involvement of epithelial-derived cytokines, immune receptors, and costimulatory molecules in the pathobiological processes that promote and sustain OLP. Read More

    Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.
    J Periodontal Res 2017 Sep 12. Epub 2017 Sep 12.
    Department of Periodontology and Synoptic Dentistry, Charité - Medical University Berlin, Berlin, Germany.
    Background And Objectives: In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approach. However, their efficacy is limited. Read More

    Human papillomavirus infection in oral potentially malignant disorders and cancer.
    Arch Oral Biol 2017 Nov 26;83:334-339. Epub 2017 Aug 26.
    Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People's Republic of China. Electronic address:
    Human papillomavirus (HPV) infects keratinocytes in the mucosa or skin, and persistent infection with HPV may lead to premalignant lesions and invasive cancer, especially cervical cancer. It has also been hypothesized that HPV infection is an etiological factor of oral squamous cell carcinoma and oral precancerous disorders such as lichen planus, leukoplakia, and erythroplakia. A high percentage of HPV in oral lesions supports the possible viral contribution, but an association of HPV infection with these lesions remains to be established. Read More

    The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?
    Mol Oral Microbiol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
    Oral lichen planus (OLP) is a variant of lichen planus (LP), a common chronic mucocutaneous inflammatory disease. Cutaneous lesions of LP are self-limiting, but OLP lesions are non-remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeutics for this disease. Read More

    Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland.
    Int J Cancer 2018 Jan 8;142(1):18-22. Epub 2017 Sep 8.
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
    The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. Read More

    Treatment of oral lichen planus using 308-nm excimer laser.
    Dermatol Ther 2017 Sep 23;30(5). Epub 2017 Aug 23.
    Department of Dermatology, 404 Hospital of People's Liberation Army, Weihai, Shandong Provence 262200, China.
    Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereby cannot be used in the treatment of OLP. Read More

    Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 23;124(3):e183-e189. Epub 2017 Jun 23.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:
    Objective: Tumor necrosis factor-α (TNF-α) has a role in the progression of the oral lichen planus (OLP). The aim of this meta-analysis study was to evaluate the salivary and serum TNF-α levels in patients with OLP.

    Study Design: We searched in the databases of PubMed/Medline, Science direct, Scopus, Web of Science, and Cochrane Library for studies reported from 1983 to 2016. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Scoring systems for Oral Lichen Planus used by differently experienced raters.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e562-e571. Epub 2017 Sep 1.
    Division of oral medicine and pathology, Dental Science Department, Ospedale Maggiore, 34100, Trieste, Italy,
    Background: Scoring systems have been widely used to evaluate the severity and activity of oral lichen planus (OLP). The aim of the present study was to compare two existing (one modified) scoring systems in the evaluation of OLP severity and correlation with pain. Three differently experienced raters were involved. Read More

    The role of microRNAs in oral lichenoid disorders. Systematic review.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e548-e553. Epub 2017 Sep 1.
    Oral Medicine, Oral and Maxillofacial Pathology. Department of Stomatology II, University of the Basque Country/ EHU, Leioa, 48940 Bizkaia, Spain,
    Background: Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD).

    Material And Methods: A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA. Read More

    Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus.
    Indian J Dermatol 2017 Jul-Aug;62(4):440
    National Skin Centre, Department of Dermatology, Singapore.
    Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. Read More

    Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential.
    Clin Oral Investig 2017 Aug 4. Epub 2017 Aug 4.
    School of Dental Medicine, Department of Oral Medicine, University of Zagreb, Zagreb, Croatia.
    Objectives: The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.

    Materials And Methods: Global protein profiling methods based on liquid chromatography coupled to mass spectrometry (LC-MS) were used, with a special emphasis on evaluation of deregulated extracellular matrix molecules expression, as well as on analyses of IG2F and IGFR2 expression in healthy mucosa, OLP and OSCC tissues by comparative semi-quantitative immunohistochemistry.

    Results: Mass spectrometry-based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and accompanied histologically unaltered tissues, respectively) identified 55 extracellular matrix proteins. Read More

    Impact of oral potentially malignant disorders on quality of life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Qld, Australia.
    Background: Oral potentially malignant disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the quality of life (QoL) of affected patients.

    Methods: Oral leukoplakia (OL), oral lichen planus (OLP) and oral submucous fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    Efficacy of low-level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
    Background: Low-level laser therapy (LLLT) has been proposed as a potential treatment strategy for the treatment of oral lichen planus (OLP). The aim of this systematic review was to assess the efficacy of LLLT, in comparison with corticosteroid therapy, in the treatment of OLP.

    Materials And Methods: This systematic review aimed to address the following focused question: "Does LLLT yield better clinical outcomes than corticosteroid therapy in the treatment of OLP?" Indexed databases were searched up to and including April 2017. Read More

    Semaphorin4D Drives CD8(+) T-Cell Lesional Trafficking in Oral Lichen Planus via CXCL9/CXCL10 Upregulations in Oral Keratinocytes.
    J Invest Dermatol 2017 Nov 29;137(11):2396-2406. Epub 2017 Jul 29.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:
    Chemokine-mediated CD8(+) T-cell recruitment is an essential but not well-established event for the persistence of oral lichen planus (OLP). Semaphorin 4D (Sema4D)/CD100 is implicated in immune dysfunction, chemokine modulation, and cell migration, which are critical aspects for OLP progression, but its implication in OLP pathogenesis has not been determined. In this study, we sought to explicate the effect of Sema4D on human oral keratinocytes and its capacity to drive CD8(+) T-cell lesional trafficking via chemokine modulation. Read More

    Treatment of oral lichen planus. Systematic review and therapeutic guide.
    Med Clin (Barc) 2017 Oct 28;149(8):351-362. Epub 2017 Jul 28.
    Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Facultad de Medicina, Universidad de Oviedo, Oviedo, España.
    In this systematic review, 55 structured articles on the therapeutic efficacy against pain and clinical signs of oral lichen planus (OLP) were analysed. The literature search was developed according to the criteria of the PRISMA system, selecting the tests performed using one of the following methodological designs: drug (active ingredient) vs. drug in different excipient or concentration, drug vs. Read More

    Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
    Asian Pac J Cancer Prev 2017 07 27;18(7):1947-1951. Epub 2017 Jul 27.
    Oral and Dental Disease Research Center, Department of Oral Medicine, Zahedan University of Medical Science, Zahedan, Iran. Email:
    The aim of present study was to evaluate salivary matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3 and MMP-13 levels in patients with oral lichen planus (OLP) and squamous cell carcinomas (SCC) as well as in healthy controls. Thirty cases of OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) clinically and histopathologically (group A), 30 with oral SCCs (group B), and 30 with no history of oral cancer, other lesions or lichen planus (group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. Unstimulated whole saliva was collected and laboratory measurement of salivary concentration of MMP-1, MMP-2, MMP-3 and MMP-13 was conducted by immuno-sorbent enzyme-linked methods. Read More

    Topical tocopherol for the treatment of ROLP: randomozed,double-blind crossover study - A query.
    Oral Dis 2017 Jul 26. Epub 2017 Jul 26.
    Dept. of Oral medicine and radiology, KMCT Dental college, Manassery, Mukkam, Calicut.
    In a recently published study "Topical tocopherol for treatment of reticular oral lichen planus: a randomized, double-blind, crossover study" (Oral Diseases, January 2017), the authors have assessed the efficacy of topical tocopherol acetate in improving the lesions and oral discomfort of patient's suffering from reticular oral lichen planus comparing it with the results achievable by administering placebo. ((1)) In the study, 34 patients with clinically diagnosed and histologically confirmed ROLP were randomly assigned to two groups, which received first one of two treatments (treatment 1 or 2) for a month, then the other (treatment 2 or 1) for another month, with a two-week washout between them. One treatment contained tocopherol acetate, the other only liquid paraffin. Read More

    Delivering resveratrol on the buccal mucosa using mucoadhesive tablets: a potential treatment strategy for inflammatory oral lesions.
    Curr Drug Deliv 2017 Jul 26. Epub 2017 Jul 26.
    Faculty of Dentistry, Federal University of Juiz de Fora, 36036-900, Juiz de Fora, MG. Brazil.
    Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. Read More

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