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    Oral lichenoid lesions of the upper lip.
    J Dermatol Case Rep 2017 Mar 31;11(1):16-19. Epub 2017 Mar 31.
    Dental Clinic, Penteli Children's General Hospital, Athens, Greece.
    Background: Oral lichen planus is a chronic inflammatory disease of unknown etiology. It is characterized by notable heterogeneity in clinical presentation and behavior.

    Main Observations: We describe 3 patients with lichenoid lesions of the upper lip and upper anterior gingiva. Read More

    Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus.
    An Bras Dermatol 2017 Mar-Apr;92(2):168-171
    Dental Research Center, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences - Tehran, Iran.
    Background:: Oral lichen planus is a potentially malignant disorder. One of the malignant transformation markers is cancer stem cells. One of the proposed marker for the detection of cancer stem cells's in head and neck cancer is aldehyde dehydrogenase. Read More

    Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review.
    Lasers Med Sci 2017 May 24. Epub 2017 May 24.
    Department of Oral Medicine and Diagnostic Sciences, Al-Farabi Colleges, Riyadh, Saudi Arabia.
    Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology and indefinite cure. This systematic review assessed the efficacy of low-level laser therapy in the treatment of symptomatic OLP. Electronic databases (PubMed, Scopus, and Web of Science) were searched from date of inception till and including December 2016, using various combinations of the following keywords: oral lichen planus, laser therapy, low-level laser therapy, and phototherapy. Read More

    Identifying the association between interleukin-6 and lichen planus: A meta-analysis.
    Biomed Rep 2017 May 7;6(5):571-575. Epub 2017 Apr 7.
    Department of Pediatric Dentistry, Jinan Stomatological Hospital, Jinan, Shandong 250002, P.R. China.
    Numerous studies have examined the association between interleukin-6 and the pathogenesis of lichen planus (LP)/oral LP (OLP) in various populations; however, there is a lack of systematic analysis. The aim of the present study was to assess this association more precisely, thus a meta-analysis was performed. Case-control studies, which were published up to December 2015, were obtained from PubMed, Embase and the China National Knowledge Infrastructure databases. Read More

    Quantification of l-carvone in toothpastes available on the Swedish market.
    Contact Dermatitis 2017 May 19. Epub 2017 May 19.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. Read More

    A panel of microRNAs can be used to determine oral squamous cell carcinoma.
    J Oral Pathol Med 2017 May 17. Epub 2017 May 17.
    Melbourne Dental School, The University of Melbourne, Melbourne, VIC, 3053, Australia.
    Background: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances of a panel of microRNA could be an objective OSCC indicator.

    Method: Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. Read More

    Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression.
    Inflammopharmacology 2017 May 13. Epub 2017 May 13.
    Hematology and Blood Banking Department, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. Read More

    Probiotics: A non-conventional therapy for oral lichen planus.
    Arch Oral Biol 2017 Apr 26;81:90-96. Epub 2017 Apr 26.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, PR China. Electronic address:
    Oral lichen planus (OLP) is a common T-cell mediated chronic inflammatory disease. Although the etiology is still unclear, present studies suggest that the composition of the oral microbiota and psychological problems are implicated in the etiology of OLP. The pathogenesis of OLP includes mainly antigen-specific and non-specific mechanisms. Read More

    Tumor-like microenvironment in oral lichen planus: evidence of malignant transformation?
    Expert Rev Clin Immunol 2017 Jun 28;13(6):635-643. Epub 2017 Feb 28.
    a The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology , Wuhan University , Wuhan , P.R. China.
    Introduction: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory autoimmune disease affecting 0.1% to 4% of the world population. The WHO has already recognized it as an oral potentially malignant disorder. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    Activated Akt/mTOR-autophagy in local T cells of oral lichen planus.
    Int Immunopharmacol 2017 May 5;48:84-90. Epub 2017 May 5.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China. Electronic address:
    Oral lichen planus (OLP) is a chronic inflammatory disease regulated by T cell-mediated immune response. Autophagy and its major inhibitory pathway Akt/mTOR participate in T cell metabolism and homeostasis, which has been implicated in autoimmune diseases. In this study, the potential involvement of autophagy and its regulatory Akt/mTOR pathway were investigated in local T cells of OLP. Read More

    Examination of circulating serum autoantibodies and hematinics is important for treatment of oral lichen planus.
    J Formos Med Assoc 2017 May 4. Epub 2017 May 4.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

    Exacerbations of oral lichen planus and elevated levels of aminotransferases.
    Int J Dermatol 2017 May 5. Epub 2017 May 5.
    Maxillo-Facial and Odontostomatology Unit (Head: prof. AB. Giannì) Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
    Background: Liver enzymes appear to be involved in oral lichen planus (OLP), but it is not known whether the elevation develops concomitantly with exacerbations of disease. We compared the levels of serum hepatic aspartate (AST) and alanine (ALT) aminotransferases as markers of OLP exacerbation in patients with chronic hepatitis C from those with chronic liver disorders, seronegative for hepatitis C virus (HCV).

    Methods: We studied 71 patients with OLP, (48 HCV seropositive and 23 HCV seronegative with chronic liver diseases) measuring AST and ALT. Read More

    Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus.
    J Oral Pathol Med 2017 Apr 30. Epub 2017 Apr 30.
    Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: There is a reported relation between hyperhomocysteinemia and lichen planus (LP). An increase in homocysteine (Hcy) and the risk of cardiovascular disease (CVD) in patients with methylenetetrahydrofolate reductase (MTHFR) mutation has been described.

    Objective: To detect MTHFR (C677T) gene polymorphism, and to find its association with CVD risk, Hcy and folic acid levels in patients with LP. Read More

    Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.
    Tumour Biol 2017 May;39(5):1010428317699113
    2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
    The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. Read More

    Evaluation Of Photodynamic Therapy In Treatment Of Oral Erosive Lichen Planus In Comparison With Topically Applied Corticosteroids.
    Photodiagnosis Photodyn Ther 2017 Apr 24. Epub 2017 Apr 24.
    Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt.
    Background: The treatment of erosive oral lichen planus represents a therapeutic challenge. Despite numerous existing remedies, some of these treatments display disappointed results. Since it is a chronic disease with no current cure, the best treatment should target mainly the reduction of the duration and severity of symptomatic outbreaks with minimal side effects. Read More

    Graham-Little-Piccardi Syndrome: A Lens Through beyond What is Known.
    Int J Trichology 2016 Oct-Dec;8(4):173-175
    Postgraduate Institute of Medical Education and Research, Kolkata, West Bengal, India.
    Graham-Little-Piccardi syndrome (GLPS) is a rare form of follicular lichen planus and comprises cicatricial alopecia of the scalp, noncicatricial alopecia of the axillae, and/or pubis and spinous follicular papules involving the trunk and extremities. We herein report a classic case of GLPS in a 49-year-old female. Uniqueness of our case is due to its additional features of frontal fibrosing alopecia (FFA). Read More

    Vulvo-vaginal ano-gingival syndrome: Another variant of mucosal lichen planus.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):86-88
    Department of Dermatology, Government Medical College, Amritsar, Punjab, India.
    Vulvo-vagino-gingival syndrome was described as a distinctive pattern of erosive plurimucosal lichen planus (LP), and it is a clinical triad of vulval, vaginal, and gingival LP. It can lead to sequelae such as vaginal and urethral stenosis which can have severe implications on the quality of life. We report a case of a 40-year-old female who developed urethral, vaginal, as well as anal stenosis as a result of long-term exclusive mucosal LP involving vulvo-vaginal and anal mucosa along with oral LP without any other cutaneous involvement. Read More

    Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data.
    Oral Oncol 2017 May 5;68:92-102. Epub 2017 Apr 5.
    Faculty of Oral and Dental Medicine, Beni Suef University, Beni Suef, Egypt.
    Objectives: For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into oral squamous cell carcinoma (OSCC).

    Materials And Methods: We searched Medline, Scopus, and Web of Knowledge for relevant observational studies. Read More

    Successful treatment of bullous lichen planus with acitretin monotherapy. Review of treatment options for bullous lichen planus and case report.
    J Dermatol Case Rep 2016 Dec 31;10(4):62-64. Epub 2016 Dec 31.
    2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, "Attikon" General University Hospital, Athens, Greece.
    Background: Bullous lichen planus (BLP) is a rare variant of lichen planus, characterized by the development of vesicular and bullous lesions, of skin, nails, hair and/or mucosa.

    Main Observations: We present a case of 63-year-old woman with BLP, unresponsive to previous therapies with topical corticosteroids, topical calcipotriol, antihistamines and oral cyclosporine (4 mg/kg/day for 4 months). She was already receiving treatment for arterial hypertension, hyperlipidemia, atrial fibrillation and uncontrolled diabetes mellitus. Read More

    Oral lichen planus: a 4-year clinical follow-up study.
    Turk J Med Sci 2017 Apr 18;47(2):514-522. Epub 2017 Apr 18.
    Institute of Odontology, Faculty of Medicine, University of Vilnius, Vilnius, Lithuania.
    Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors.

    Materials And Methods: All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Read More

    Ascorbic acid deficiency in patients with lichen planus.
    J Immunoassay Immunochem 2017 Apr 19:1-8. Epub 2017 Apr 19.
    c Department of Dermatology , Carol Davila University of Medicine and Pharmacy , Bucharest , Romania.
    Objectives: Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study, the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin.

    Material And Method: We analyzed the level of urinary ascorbic acid (reflectometric method) in 77 patients with LP (cutaneous LP (CLP)-49 cases; oral LP (OLP)-28 cases) and 50 control subjects. Read More

    Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus.
    Arch Oral Biol 2017 Apr 7;80:110-116. Epub 2017 Apr 7.
    Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China.
    Objective: Oral lichen planus (OLP) presents with large numbers of T lymphocytes accumulating beneath the epithelium of the oral mucosa; however, its aetiology remains obscure. A potential role for an emerging novel T cell subset, Th9, in OLP has recently been suggested but remains to be clarified. The current aim was to investigate the expression and potential clinical significance of Th9 cells in distinct subtypes of OLP. Read More

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

    Treatment of recalcitrant erosive oral lichen planus and desquamative gingivitis with oral apremilast.
    J Dermatol Case Rep 2016 Nov 30;10(3):56-57. Epub 2016 Nov 30.
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center and University of Toronto, Toronto, Canada.
    Background: Erosive oral lichen planus and desquamative gingivitis are uncommon but severe debilitating variants of oral lichen planus. Treatment of these presentations is difficult and challenging.

    Main Observation: A 44-year-old woman was referred to the dermatology clinic with chronic painful lichen planus-related gingivitis and buccal erosions. Read More

    Detection of AMA-M2 in human saliva: Potentials in diagnosis and monitoring of primary biliary cholangitis.
    Sci Rep 2017 Apr 11;7(1):796. Epub 2017 Apr 11.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China.
    Serum anti-mitochondrial antibody type 2 (AMA-M2) is considered as a pivotal biomarker for the diagnosis of primary biliary cholangitis (PBC). However, serological tests have many limitations, including inconvenience, invasiveness, and infection risks. Thus, a less invasive approach to detect AMA-M2 titer is desirable. Read More

    Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.
    Med Oral Patol Oral Cir Bucal 2017 May 1;22(3):e297-e306. Epub 2017 May 1.
    University of Talca, Lircay Av. S/N, Talca, Chile, Zip code 3460000,
    Background: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce.

    Material And Methods: This study investigated the frequency of OD in a Chilean population. Read More

    Psychological profiles in patients with Symptomatic Reticular forms of Oral Lichen Planus: a prospective cohort study.
    J Oral Pathol Med 2017 Apr 8. Epub 2017 Apr 8.
    University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences.
    Objectives: To analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (R) forms of oral lichen planus (OLP).

    Materials And Methods: Thirty symptomatic R-OLP (sR-OLP) patients were compared with an equal number of non-symptomatic R-OLP (nsR-OLP) patients, burning mouth syndrome (BMS) patients and healthy subjects (HS). The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI) and the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) were administered. Read More

    Oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case.
    BMJ Case Rep 2017 Apr 6;2017. Epub 2017 Apr 6.
    Oral Medicine, University of Bristol Dental Hospital, Bristol, UK.
    Oral hairy leukoplakia (OHL) is an oral mucosal lesion that is associated with Epstein-Barr virus infection. It commonly presents as an asymptomatic, non-removable white patch on the lateral borders of the tongue in individuals who are immunocompromised. Historically, OHL was thought to be pathognomonic of HIV infection; however, it is now an established phenomenon in a range of conditions affecting immune competence. Read More

    Two Unusual Cases of Oral Lichen Planus Arising After Oral Squamous Cell Carcinoma.
    Int J Surg Pathol 2017 Mar 1:1066896917699070. Epub 2017 Mar 1.
    1 University of Bologna, Bologna, Italy.
    Autoimmune diseases occur when the immune system fails to recognize self-antigens expressed on the body's own cells and attacks them. Oral lichen planus (OLP) is a chronic autoimmune mucocutaneous disease of the oral cavity characterized by white/red lesions. Considered a potentially malignant disorder, OLP evolution into oral squamous cell carcinoma (OSCC) is still a matter of debate. Read More

    Roles of serum uric acid, prolactin levels, and psychosocial factors in oral lichen planus.
    J Oral Sci 2017 ;59(1):139-146
    Department of Oral Medicine and Radiology, Subharti Dental College.
    Free radicals play important roles in the mechanisms underlying lichen planus (LP). Uric acid (UA) is an important anti-oxidant in plasma. Prolactin (PRL) is an immunomodulatory hormone that may promote LP, as has been documented in other autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Read More

    Topical application of morphine for wound healing and analgesia in patients with oral lichen planus: a randomized, double-blind, placebo-controlled study.
    Clin Oral Investig 2017 Mar 28. Epub 2017 Mar 28.
    Department of Oral Medicine, Dental Radiology and Oral Surgery, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Assmannshauser Str. 4-6, 14197, Berlin, Germany.
    Objective: The objective of this study was to investigate the effect of topical morphine on erosive/ulcerative lesions in patients with oral lichen planus (OLP). Previous studies reported on an enhanced remission of skin wounds when morphine was applied topically.

    Materials And Methods: This was single-center, prospective, double-blind, placebo-controlled, randomized, multi-arm (3), phase II study (RCT). Read More

    Topical agents for oral cancer chemoprevention: A systematic review of the literature.
    Oral Oncol 2017 Apr 2;67:153-159. Epub 2017 Mar 2.
    Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA; Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
    Objectives/hypothesis: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD).

    Methods: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence. Read More

    VEGFR-3 Expression in Oral Lichen Planus
    Asian Pac J Cancer Prev 2017 02 1;18(2):381-384. Epub 2017 Feb 1.
    Oral and Maxillofacial Pathology Department, Dental Faculty, Babol University of Medical Sciences, Babol, Iran.
    Background and objective: Given the postulated the role of inflammation and possible contribution of lymphangiogenesis in oral lichen planus, this study aimed to assess any associated presence of VEGFR-3. Material and Methods: This cross-sectional study was performed on 52 formalin fixed and paraffin embedded blocks of oral lichen planus (pathological diagnosis based on Modified WHO criteria), comprising 25 of erosive and 27 of reticular type, along with 60 samples of normal mucosa (with minimal inflammation from clinical and histopathological aspects) obtained at crown lengthening surgery. Four micron sections were cut from paraffin blocks and stained with H and E for confirmation of diagnosis and by immunohistochemistry with primary antibodies against VEGFR-3. Read More

    Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017 ;15(2):177-182
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Subgingival Microbiota in Caucasian Patients With Desquamative Gingivitis: A Cross-Sectional Study.
    J Periodontol 2017 Mar 17:1-14. Epub 2017 Mar 17.
    Department of Surgical Sciences, CIR - Dental School, University of Turin, Turin, Italy.
    Background: The presence of epithelial desquamation, erythema, and erosions on the gingival tissue is usually described in literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatological disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study was to investigate the prevalence of 11 periodonto-pathogenic microorganisms in DG cases and to compare it with microbiologic status of individuals affected by plaque-induced gingivitis (GI). Read More

    Association between polymorphisms in interleukins and oral lichen planus: A meta-analysis.
    Medicine (Baltimore) 2017 Mar;96(11):e6314
    Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
    Background: More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene polymorphisms with the OLP risk. Read More

    Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue.
    J Oral Pathol Med 2017 Mar 10. Epub 2017 Mar 10.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Morioka, Iwate, Japan.
    Background: Oral lichen planus (OLP) is a T-cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Read More

    A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.
    Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1070. Epub 2016 Dec 23.
    Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
    Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Read More

    Free palatal mucosal graft for treatment of erosive oral lichen planus.
    J Formos Med Assoc 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:

    Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus.
    PLoS One 2017 9;12(3):e0173017. Epub 2017 Mar 9.
    Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
    Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammation. Read More

    Gene expression of miRNA-138 and cyclin D1 in oral lichen planus.
    Clin Oral Investig 2017 Mar 8. Epub 2017 Mar 8.
    Department of Medical Biochemistry& Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt.
    Objectives: This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis.

    Methods: Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression. Read More

    Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing.
    Oncol Rep 2017 Apr 2;37(4):2355-2365. Epub 2017 Mar 2.
    Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
    Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the differently expressed genes (DEGs) in OLP vs. Read More

    [Frontal fibrosing alopecia: A prospective study of 20 cases].
    Ann Dermatol Venereol 2017 Feb 28. Epub 2017 Feb 28.
    Centre d'anatomopathologie Hassane, Rabat, Maroc.
    Background: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment.

    Patients And Methods: This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco. Read More

    Oral lichen planus in childhood: a case series.
    Int J Dermatol 2017 Jun 3;56(6):641-652. Epub 2017 Mar 3.
    Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.
    Background: Although the exact incidence of pediatric oral lichen planus (OLP) is unknown, the oral mucosa seems to be less commonly involved, and the clinical presentation is often atypical. The aim of the study is to present a case series of OLP in childhood.

    Methods: From our database, we retrospectively selected and analyzed the clinical data of OLP patients under the age of 18 where the diagnosis had been confirmed by histopathological analysis. Read More

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