4,613 results match your criteria Oral Lichen Planus


Challenges of Oral Medicine Specialistsat the time ofCOVID-19 Pandemic.

Oral Dis 2020 Jul 2. Epub 2020 Jul 2.

Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Milan, Italy.

The novel coronavirus disease 2019 (COVID-19) had caused major disruptions in medical and dental care across the world, affecting secondary care services that had to rapidly adapt to new circumstances. Postponed and delayed oral medicine (OM) care, deferring non-urgent follow-ups in case of patients because of COVID-19 crisis, and limited access to health care, may have lead serious consequences fororal and systemic health (Arduino et al, 2020; Jones et al, 2020). Deferred diagnosis of a malignant conditionwhen suspected or even dysplasia in oralleucoplakia cases vastly implies the clinical outcome, influencing treatment and prognosis, subsequently(Meng et al, 2020). Read More

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http://dx.doi.org/10.1111/odi.13520DOI Listing

The expression of Cathepsin L in oral lichen planus.

J Oral Biol Craniofac Res 2020 Jul-Sep;10(3):281-286. Epub 2020 Jun 16.

Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.

Background: Malignant transformation of oral lichen planus (OLP) was reported particularly in erosive type, however, it remains inconclusive. Cathepsin L was shown to promote tumor growth and invasion in many cancers. Therefore, cathepsin L expression in erosive and non-erosive OLP compared with oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) were investigated. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322187PMC

[Modern perspectives of oral squamous cell carcinoma].

Authors:
A A Ivina

Arkh Patol 2020 ;82(3):55-60

Peoples' Friendship University of Russia, Moscow, Russia.

The article is devoted to the modern perspectives of the etiology, pathogenesis, diagnosis and prognostic factors in theoral squamous cell carcinoma. In the new edition of the WHO Classification of Head and Neck Tumors of 2017, the concept of potentially malignant diseases is introduced, which include erythroplakia, leukoplakia, oral submucous fibrosis, dyskeratosiscongenita, smokeless tobacco keratosis, palatallesions associated with reverse smoking, chronic candidiasis, lichen planus, discoid lupus erythematosus, syphilitic glossitis and actinic keratosis (liponly). A binary system for assessing oral epithelial dysplasia assessing is proposed. Read More

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http://dx.doi.org/10.17116/patol20208203155DOI Listing
January 2020

Treatment of oral lichen planus with mucoadhesive mycophenolate mofetil patch: A randomized clinical trial.

Clin Exp Dent Res 2020 Jun 26. Epub 2020 Jun 26.

Department of Pharmaceutics, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology which is known as a premalignant disease. A complete cure has not been found for this condition. Mycophenolate mofetil (MMF) is a new drug that seems to be effective in improving OLP lesions. Read More

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http://dx.doi.org/10.1002/cre2.302DOI Listing

Assessment of the Role of Vitamin D in the Treatment of Oral Lichen Planus.

J Contemp Dent Pract 2020 Apr 1;21(4):390-395. Epub 2020 Apr 1.

Department of Dentistry, Patna Medical College and Hospital, Patna, Bihar, India, Phone: +91 9608217026, e-mail:

Aim: Lichen planus is an autoimmune disease that can affect the skin and mucous membranes, including the oral mucosa. Vitamin D plays a very important role in the bone health along with boosting immunity. This study was carried out to assess the role of vitamin D in the treatment of oral lichen planus. Read More

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Oral Lichen Planus in a 7-year-old Child: A Rare Case Report.

Int J Clin Pediatr Dent 2020 Jan-Feb;13(1):91-93

Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, India.

Lichen planus is a chronic inflammatory mucocutaneous disease reported most frequently in adults and relatively rare in children with the prevalence being 0.03%. This article reports a case of oral lichen planus (OLP) in a 7-year-old girl without any attendant skin lesions, diagnostic workup, and management protocol for the same. Read More

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http://dx.doi.org/10.5005/jp-journals-10005-1713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299881PMC

Histopathological evaluation of nail lichen planus: a cross-sectional study.

J Cutan Pathol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

Introduction: Upto10% patients with lichen planus (LP) have nail involvement; still there is a paucity of studies on histopathological features. Nevertheless, nail biopsy is the diagnostic standard, especially for isolated nail LP.

Methodology: Nails of 45 patients with nail LP were evaluated clinically and biopsies taken from most involved nail (25 nail bed and 20 matrix biopsies). Read More

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http://dx.doi.org/10.1111/cup.13783DOI Listing
June 2020
1.560 Impact Factor

Oral Lichen Planus - Related Connection with HLA-System Antigens.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Jun;41(1):65-77

University Dental Clinical Centre, Departement of periodontology and oral pathology, Skopje, R.N. Macedonia.

Aim: To determine whether there is an immunogenic connection and antigen difference between the HLA antigens in the erosive (EOLP) and reticular (ROLP) oral lichen planus.

Materials And Method: 73 patients with ROLP and EOLP have been tested. Typing of the HLA antigens has been made for locus A and B. Read More

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http://dx.doi.org/10.2478/prilozi-2020-0024DOI Listing

Application of a non-invasive oral brushing procedure based on bisulfite sequencing of a 13-gene panel to study high-risk OSCC patients.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Department of Biomedical and Neuromotor Sciences, Functional MR Unit, IRCCS Istituto Delle Scienze Neurologiche di Bologna, University of Bologna, Bologna, Italy.

Background: A non-invasive sampling procedure for the early detection of Oral Squamous Cell Carcinoma (OSCC) based on DNA methylation analysis of a panel of 13 genes was applied in 4 different OSCC risk-group of patients. Aim of the study is to evaluate the between-group differences and the variables related to the methylation profile of each group.

Methods: Oral brushing samples were collected from 54 healthy subjects, 31 Oral Leukoplakia (OL) patients, 18 Oral Lichen Planus (OLP) patients and 26 patients previously treated for OSCC. Read More

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http://dx.doi.org/10.3233/CBM-190422DOI Listing

Salivary β2-microglobulin levels in patients with erosive oral lichen planus and squamous cell carcinoma.

BMC Res Notes 2020 Jun 17;13(1):294. Epub 2020 Jun 17.

Dental Research Center and Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.

Objectives: β2 microglobulin, as a biomarker, is used for the diagnosis of oral malignant and pre-malignant lesions. The components of the microglobulin system can directly or indirectly help grow and develop tumors. The present study aims to compare beta-2 microglobulin levels in patients with lichen planus of the esophagus, oral squamous cell carcinoma, and healthy individuals. Read More

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http://dx.doi.org/10.1186/s13104-020-05135-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301459PMC

Expert Recommendations for Prevention, Treatment and Care of Oral Ulcers and Other Mucosal Diseases during the Coronavirus Outbreak.

Chin J Dent Res 2020 ;23(2):95-98

In December 2019, some new and unexplained cases of pneumonia were found in Wuhan, Hubei province, China, and were later named as coronavirus disease 2019 by the World Health Organisation. The number of cases increased rapidly, and the virus spread continuously. Tens of thousands of medical staff throughout the country have since rushed to Wuhan to provide intensive medical treatment. Read More

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http://dx.doi.org/10.3290/j.cjdr.a44744DOI Listing

[Pathogenicity and drug-resistance analysis of in patients with oral candidiasis].

Authors:
C He Y Song X K Chang

Zhonghua Yi Xue Za Zhi 2020 Jun;100(23):1778-1782

Department of Clinical Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China.

To investigate the detection rate, population features and antifungal drug susceptibility of in patients with oral candidiasis. The saliva fungi culture cases and the ratio of in patients with oral candidiasis were analyzed during 2014-2018. Fungal species were identified by CHROMagar Candida chromogenic medium and API 20C AUX yeast identification kit. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200302-00555DOI Listing

Micronutrients Profile in Oral Lichen Planus: a Review Literature.

Biol Trace Elem Res 2020 Jun 12. Epub 2020 Jun 12.

Department of Oral & Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.

Oral lichen planus (OLP) is a relatively common chronic inflammatory disease. The micronutrients are critical factors in health of oral mucous and proper function of immune system. There have not been any review articles for evaluating trace element levels before and after standard treatments of OLP. Read More

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http://dx.doi.org/10.1007/s12011-020-02221-9DOI Listing

Autoimmune mucocutaneous blistering diseases in the south of Italy: a 25-year retrospective study on 169 patients.

J Oral Pathol Med 2020 Jun 12. Epub 2020 Jun 12.

Department of Neurosciences, Reproductive Sciences and Dentistry, Federico II University of Naples, Naples, Italy.

Background: Autoimmune mucocutaneous blistering diseases (AMBDs) represent a heterogeneous group of organ-specific and potentially life-threatening diseases. We sought to determine the relationship between clinical remission and therapeutic regimens with clinical type and phenotype of AMBDs, as well as clinical outcomes achieved based on different therapeutic regimens.

Methods: A retrospective single-center study on 169 AMBDs patients, including pemphigus vulgaris (PV), mucous membrane pemphigoid (MMP), paraneoplastic autoimmune multiorgan syndrome (PAMS), and lichen planus pemphigoides (LPP), was performed from 1994 to 2019 in an oral medicine tertiary center, where we collected sociodemographic data, clinical type and phenotype, prescribed therapies, and related outcomes. Read More

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http://dx.doi.org/10.1111/jop.13059DOI Listing

Role of tumor suppressor protein p16 in patients with oral lichen planus.

J BUON 2020 Mar-Apr;25(2):1193-1198

Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.

Purpose: Oral lichen planus (OLP), is considered premalignant condition. This study tried to investigate the possibility of malignant transformation in OLP patients, by measuring the level of tumor suppressor protein p16INK4A, which is a product of the cyclin-dependent kinase inhibitor 2 (CDK2). CDK inhibitors may be responsible for maintenance of cell cycle. Read More

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Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial.

Dermatol Res Pract 2020 20;2020:4298193. Epub 2020 May 20.

Department of Community Oral Health, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP).

Materials And Methods: This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. Read More

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http://dx.doi.org/10.1155/2020/4298193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256737PMC

Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment.

Probiotics Antimicrob Proteins 2020 Jun 6. Epub 2020 Jun 6.

Department of Oral Medicine, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School & Hospital of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai, People's Republic of China, 200072.

Oral lichen planus (OLP) is a T cell-mediated common chronic inflammatory mucosal disease, with limited therapies available for long-term use. Previous study showed that ratio of genus Streptococcus decreased significantly in OLP patients when compared with controls. Buccal cotton swab samples of 43 OLP patients and 48 healthy individuals were collected for real-time quantitative polymerase chain reaction (RT-PCR) to investigate relative abundance alteration of Streptococcus salivarius in OLP lesions. Read More

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http://dx.doi.org/10.1007/s12602-020-09664-5DOI Listing

Urinary metabolomic signatures in reticular oral lichen planus.

Heliyon 2020 May 22;6(5):e04041. Epub 2020 May 22.

College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guian new area 550025, PR China.

Oral lichen planus (OLP) is a chronic inflammatory disease. Among all the clinical forms in OLP, reticular type has the highest incidence rate. Previous studies have applied metabolomics to investigate the metabolic changes of oral mucosa and blood samples from reticular OLP patients. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256305PMC

Emerging functions and clinical applications of exosomes in human oral diseases.

Cell Biosci 2020 24;10:68. Epub 2020 May 24.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fluids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. Read More

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http://dx.doi.org/10.1186/s13578-020-00424-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245751PMC

Oral lichen planus: A chronic inflammatory model to study the regulation of the Toll-like receptor signaling in oral keratinocytes.

J Oral Biosci 2020 Jun 26;62(2):115-122. Epub 2020 May 26.

Departamento de Estudios Básicos Integrados. Grupo Estudios BioSociales Del Cuerpo. School of Dentistry, Universidad de Antioquia, Medellin, Antioquia, Colombia. Electronic address:

Background: Oral lichen planus (OLP) is a chronic inflammatory disease with a strong immune mechanism involved. Although no causal factor is identified in OLP, a cellular hypersensitivity has been associated with its pathophysiology. Furthermore, the chronicity of the disease could cause its malignant transformation. Read More

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http://dx.doi.org/10.1016/j.job.2020.05.003DOI Listing

Applying dental implant therapy in patients with oral lichen planus: a review of literature.

Int J Implant Dent 2020 May 27;6(1):21. Epub 2020 May 27.

School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.

Lichen planus (LP) is a violent, paranormal inflammatory disease that can affect the skin or any lining of the mucous membrane. LPs are a branch of immune-mediated inflammatory disease (IMID) that collaborates with the function and structure of the immune system that are precipitated through various etiological infectious agents. Oral lichen planus (OLP) is one of the most common kinds of IMID. Read More

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http://dx.doi.org/10.1186/s40729-020-00216-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250998PMC

Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus - A pilot study.

Indian J Dent Res 2020 Mar-Apr;31(2):277-281

Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M S Ramaiah University of Applied Sciences, M S R Nagar, Bangalore, Karnataka, India.

Context: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion molecules (VAMs). Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_653_18DOI Listing

Microbial Community Analysis of Saliva and Biopsies in Patients With Oral Lichen Planus.

Front Microbiol 2020 5;11:629. Epub 2020 May 5.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

The specific etiology and pathogenesis of oral lichen planus (OLP) remain elusive, and microbial dysbiosis may play an important role in OLP. We evaluated the saliva and tissue bacterial community of patients with OLP and identified the colonization of bacteria in OLP tissues. The saliva ( = 60) and tissue ( = 24) samples from OLP patients and the healthy controls were characterized by 16S rDNA gene sequencing and the bacterial signals in OLP tissues were detected by fluorescence hybridization (FISH) targeting the bacterial 16S rDNA gene. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219021PMC
May 2020
3.941 Impact Factor

Is oral lichen planus a risk factor for peri-implant diseases? A systematic review and meta-analysis.

BMC Oral Health 2020 May 20;20(1):150. Epub 2020 May 20.

Department of Periodontology and Oral Medicine, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, NO.195 Dongfeng West Road, Guangzhou, 510140, China.

Background: To evaluate whether oral lichen planus (OLP) is a risk factor for peri-implant diseases (PIDs) with a systematic review and meta-analysis.

Methods: Five electronic databases including Medline, Embase, Web of Science, the Cochrane Library and Scopus were searched. The included studies are observational human studies written in English. Read More

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http://dx.doi.org/10.1186/s12903-020-01134-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240920PMC

Oral bacterial diversity is inversely correlated with mucosal inflammation.

Oral Dis 2020 May 17. Epub 2020 May 17.

Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Objective: We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP).

Methods: Patients with RAS (n = 15) and LP (n = 18) and healthy controls (n = 13) were recruited using criteria to reduce the effect of factors that influence the microbiota structure independently of oral mucosal disease. Clinical severity was quantified using validated scoring methods. Read More

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http://dx.doi.org/10.1111/odi.13420DOI Listing

Frontal Fibrosing Alopecia: A Retrospective Study of 75 Patients.

Actas Dermosifiliogr 2020 May 14. Epub 2020 May 14.

Servicio de Dermatología, Hospital Universitario Infanta Sofía, Madrid, España.

Background And Objective: Frontal fibrosing alopecia is an increasingly common form of scarring alopecia. The aim of this study was to describe the demographic and clinical characteristics of patients with FFA seen at the trichology unit of a medium-sized regional hospital and to report on treatments used.

Material And Method: We reviewed the medical records of all patients with FFA seen at the trichology unit of Hospital Universitario Infanta Sofía in Madrid, Spain between May 2016 and May 2018. Read More

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http://dx.doi.org/10.1016/j.ad.2020.03.003DOI Listing

Nothing to sneeze at: Histamine and histamine receptors in oral carcinogenesis.

Oral Dis 2020 May 12. Epub 2020 May 12.

Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.

Oral squamous cell carcinoma (OSCC), the most common oral malignancy, shows an increasing rate of incidence worldwide. In spite of the recent advances in cancer research, OSCC therapy continues to have unfavourable outcomes, and thus, patient's prognosis remains relatively poor. Current research has been devoted to identifying novel therapeutic targets also in the tumour microenvironment (TME). Read More

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http://dx.doi.org/10.1111/odi.13411DOI Listing

Induction of High Endothelial Venule-like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study.

J Histochem Cytochem 2020 May;68(5):343-350

Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui.

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease involving the oral mucosa and skin. Both oral LP (OLP) and cutaneous LP (CLP) are histopathologically characterized by dense subepithelial lymphocyte infiltrates; however, the mechanisms underlying lymphocyte recruitment to sites of LP lesions are not fully understood. Here, we assessed the induction of peripheral lymph node addressin (PNAd)-expressing high endothelial venule (HEV)-like vessels in 19 OLP and 17 CLP cases. Read More

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http://dx.doi.org/10.1369/0022155420923272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226624PMC

Clinicopathological and prognostic characterization of oral lichenoid disease and its main subtypes: A series of 384 cases.

Med Oral Patol Oral Cir Bucal 2020 Jul 1;25(4):e554-e562. Epub 2020 Jul 1.

Department of Stomatology II University of the Basque Country (UPV/EHU) Barrio Sarriena sn. 48940. Leioa, Spain

Background: To clinicopathologically characterize the diagnosis of oral lichenoid disease (OLD) and its main subtypes: oral lichen planus (OLP) and oral lichenoid lesion (OLL), in order to correctly asses their prognosis.

Material And Methods: Ambispective cohort study of 384 patients with diagnosis of OLD, based on pre-established clinical and histopathological criteria. We have analysed 272 (70. Read More

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http://dx.doi.org/10.4317/medoral.23576DOI Listing

A case of delayed allergic reaction caused by local injection of triamcinolone acetonide.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):216-220

Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology & Hunan Key Laboratory of Oral Health Research, Central South University, Changsha 410008, China

Glucocorticoid is a commonly used anti-inflammatory and anti-allergic drug in clinic. Allergic reactions caused by glucocorticoids are rare in clinic. Glucocorticoid allergy is a type of allergic reaction caused by glucocorticoid as an allergen, and its clinical manifestations of hypersensitivity are not specific. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180584DOI Listing
February 2020

Evaluation and Expression of Survivin in Potentially Malignant Lesions and Squamous Cell Carcinoma: A Comparative Study.

Cureus 2020 Apr 5;12(4):e7551. Epub 2020 Apr 5.

Oral and Maxillofacial Surgery, Thai Moogambigai Dental College and Hospital, Chennai, IND.

Introduction Overexpression of survivin, an anti-apoptotic protein, has been associated with the progression of cancer, resistance to drugs, and a poor prognosis. The expression level of survivin indicates the progression of the disease, early recurrence, and a failure to respond to therapy. Our study was a retrospective analysis performed on archival specimens. Read More

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http://dx.doi.org/10.7759/cureus.7551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202583PMC

Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders.

Kurume Med J 2020 Jul 1;66(1):15-27. Epub 2020 May 1.

AL-FALAH School of Medical Sciences and Research Center, AL- Falah University.

Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (TXN2). They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. Read More

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http://dx.doi.org/10.2739/kurumemedj.MS661009DOI Listing

Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action.

J Ethnopharmacol 2020 Aug 1;258:112913. Epub 2020 May 1.

Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Characteristic Chinese Drug Resources in Southwest China, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Chengdu 611137, China. Electronic address:

Ethnopharmacological Relevance: Paeoniae Radix Alba (PRA, called baishao in China), the root of Paeonia lactiflora Pall., has shown a rich medicinal value for more than 2000 years. PRA is used in local medicine and traditional medicine for autoimmune diseases associated with inflammation. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112913DOI Listing
August 2020
2.998 Impact Factor

Meaningful improvement thresholds in measures of pain and quality of life in oral lichen planus.

Oral Dis 2020 May 4. Epub 2020 May 4.

UCL Eastman Dental Institute, London, UK.

Objectives: To evaluate the responsiveness of measures of pain and oral health-related quality of life (OH-QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population.

Methods: Data from baseline and 4-month follow-up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14-item Oral Health Impact Profile (OHIP-14), 15-item and 26-item Chronic Oral Mucosal Disease Questionnaire (COMDQ-15; COMDQ-26) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. Read More

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http://dx.doi.org/10.1111/odi.13379DOI Listing

Nails: The Window to the Nose? Update on Yellow Nail Syndrome.

Dermatol Pract Concept 2020 3;10(2):e2020031. Epub 2020 Apr 3.

Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

Background: Yellow nail syndrome is a rare condition characterized by typical nail alterations and variable presence of lymphedema and respiratory disease. The pathogenesis is still obscure, with most of the literature deriving from case reports and few investigations. The most reported respiratory conditions associated with yellow nail syndrome are pleural effusion and bronchiectasis, whereas association with rhinosinusitis is rarer. Read More

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http://dx.doi.org/10.5826/dpc.1002a31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190560PMC

The effect of smoking on clinical presentation and expression of TLR-2 and CD34 in Oral lichen Planus patients: clinical and immunohistochemical study.

BMC Oral Health 2020 Apr 29;20(1):129. Epub 2020 Apr 29.

Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Background: Oral lichen planus is a chronic inflammatory disease which is considered as a potential precancerous condition. Numerous studies have confirmed that inflammation is a strong risk factor for cancer development. Smoking is associated with potentially malignant disorders of the oral and oropharyngeal mucosa. Read More

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http://dx.doi.org/10.1186/s12903-020-01118-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191681PMC

Relationship between salivary vitamin D deficiency and oral lichen planus.

Photodermatol Photoimmunol Photomed 2020 Apr 26. Epub 2020 Apr 26.

Department of Oral & Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.

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http://dx.doi.org/10.1111/phpp.12567DOI Listing

Answer to Photo Quiz White striae and erosions of the oral mucosa, but it is not oral lichen planus.

Neth J Med 2020 Apr;78(3):147

Unit of Oral and Maxillofacial Surgery, Ca Foncello Hospital, Treviso, Italy.

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White striae and erosions of the oral mucosa, but it is not oral lichen planus.

Neth J Med 2020 Apr;78(3):146

Unit of Oral and Maxillofacial Surgery, Ca Foncello Hospital, Treviso, Italy.

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Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22.

Hum Exp Toxicol 2020 Apr 24:960327120918291. Epub 2020 Apr 24.

Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

Background: Quercetin exerts anti-inflammatory effects, but whether it can benefit patients with the chronic inflammatory disease of oral lichen planus (OLP), which is a common chronic mucocutaneous disorder with an immune-mediated pathogenesis, is unclear. The present research examined the impacts of quercetin in a cell-based OLP model in which human oral keratinocytes (HOKs) were treated with lipopolysaccharide (LPS).

Methods: Effects of quercetin on viability, proliferation, and apoptosis of HOKs were assessed using the Cell Counting Kit-8 assay, Western blotting, and flow cytometry, respectively. Read More

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http://dx.doi.org/10.1177/0960327120918291DOI Listing

Serological and psychological assessment of patients with oral lichen planus using serum cortisol levels and hads questionnaire-a case control study.

J Popul Ther Clin Pharmacol 2020 Apr 6;27(2):e19-e27. Epub 2020 Apr 6.

Department of Oral Medicine and radiology, Panineeya institute of dental sciences, Hyderabad.

Background: Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disorder directed against antigens secreted by the basal cell layer, with an incidence of 0.02-0.22% in Indian population and showing female predilection. Read More

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http://dx.doi.org/10.15586/jptcp.v27i2.667DOI Listing

Prevalence of oral premalignant lesions and conditions among the population of Kanpur City, India: A cross-sectional study.

J Family Med Prim Care 2020 Feb 28;9(2):1080-1085. Epub 2020 Feb 28.

Department of Public Health Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India.

Background: The habit of smoking and chewing tobacco is associated with various types of oral mucosal lesions and conditions, many of which pose a potential threat to cancer growth. The present study aims to evaluate the prevalence of potentially malignant lesions (PML) and oral cancer in North India and to identify the associated risk factors.

Materials And Methods: A cross-sectional study was carried out in the Department of Oral Medicine and Radiology Rama Dental College Hospital and research center Kanpur over a period of 5 years with1,10,625 patients. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_912_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114062PMC
February 2020

Report of two cases of mucous membrane pemphigoid with frontal fibrosing alopecia: a variant of lichen planus pemphigoides or an incidental finding?

Clin Exp Dermatol 2020 Apr 20. Epub 2020 Apr 20.

Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.

Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by the coexistence of both lichen planus and either bullous pemphigoid or mucous membrane pemphigoid (MMP) features. Frontal fibrosing alopecia (FFA) is a scarring alopecia, generally considered a form of lichen planopilaris. We report two patients with concomitant FFA and MPP. Read More

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http://dx.doi.org/10.1111/ced.14248DOI Listing

No evidence for association between cutaneous lichen planus and hepatitis B and C virus infection in south Poland - a case-control study.

Int J Dermatol 2020 Jun 19;59(6):698-703. Epub 2020 Apr 19.

Department of Dermatology, University of Rzeszów, Rzeszów, Poland.

Background: The incidence of hepatitis C virus (HCV) infection among patients with lichen planus (LP) varies considerably. Currently, there is more evidence for the association between hepatitic C and oral LP (OLP) than cutaneous LP (CLP). There is also lack of data on the Polish population. Read More

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http://dx.doi.org/10.1111/ijd.14880DOI Listing

Clinicopathological and prognostic characteristics of oral squamous cell carcinomas arising in patients with oral lichen planus: A systematic review and a comprehensive meta-analysis.

Oral Oncol 2020 07 16;106:104688. Epub 2020 Apr 16.

School of Dentistry, University of Granada, Granada, Spain. Electronic address:

Objectives: To evaluate current evidence in relation to the prognostic and clinicopathological significance of oral squamous cell carcinomas arising in patients with oral lichen planus (OLP-OSCC).

Material And Methods: We searched PubMed, Embase, Web of Science and Scopus for studies published before May-2019. We evaluated the quality of studies (QUIPS tool). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104688DOI Listing

A probable surge in oral lichen planus cases under the aura of coronavirus in females in India.

Oral Oncol 2020 Apr 15:104714. Epub 2020 Apr 15.

All India Institute of Medical Sciences, Bhubaneswar, India.

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http://dx.doi.org/10.1016/j.oraloncology.2020.104714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158810PMC

Aquaporin3 (AQP3) expression in oral epithelium in oral lichen planus.

Exp Mol Pathol 2020 Apr 11;115:104441. Epub 2020 Apr 11.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Iran; Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Lichen Planus is an autoimmune disease of skin and mucous membranes, including oral mucosa and genital organs, with the potential to undergo a malignant transformation. Xerostomia and the salivary gland hypofunction are common manifestations and complications in oral lichen planus (OLP), whose exact cause has not been well defined yet. Aquaporins (AQP) are a family of membrane channel cell proteins which play an important role in the intercellular water permeability. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104441DOI Listing

Epigenetic factors involved in the pathophysiology of inflammatory skin diseases.

J Allergy Clin Immunol 2020 Apr;145(4):1049-1060

Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address:

Epigenetics has been discussed as a potential factor influencing the pathophysiology and severity of inflammatory skin diseases. In recent years, emerging evidence suggests that epigenetic mechanisms are involved in the pathophysiology of not only atopic dermatitis (AD) and psoriasis (PSO) but also lupus erythematosus and oral lichen. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of methylation patterns in inflammatory skin disease. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.10.015DOI Listing

Evaluation of PD-L1, PD-L2, PD-1 and cytotoxic immune response in oral lichen planus.

Oral Dis 2020 Apr 7. Epub 2020 Apr 7.

Department of Stomatology (Oral Medicine and Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, Brazil.

Objective: To investigate the expression of programmed death-ligands 1 and 2 (PD-L1, PD-L2), programmed death-1 (PD-1), CD8 and granzyme B (GrB), as well as its correlation with the severity of oral lichen planus (OLP).

Materials And Methods: In a collaborative study, 33 cases of OLP were evaluated according to the latest criteria proposed by the American Academy of Oral and Maxillofacial Pathology (AAOMP/2016) and were submitted to immunohistochemistry. Positivity was measured semiquantitatively (PD-L1, PD-L2) and quantitatively (PD-1, CD8, GrB). Read More

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http://dx.doi.org/10.1111/odi.13344DOI Listing