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    Drug-induced oral lichenoid reactions: a real clinical entity? A systematic review.
    Eur J Clin Pharmacol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Libraries, New Orleans School of Dentistry, Louisiana State University Health Sciences Center, 1100 Florida Ave, New Orleans, LA, 70119, USA.
    Purpose: Drug-induced oral lichenoid reactions (DIOLRs) have been extensively reported in the literature, but the validity of the causality relationship between any drug and the oral lichenoid lesions (OLLs) still remains questionable. We sought to determine whether this causality relationship really exists, whether a resolution of the oral lesions upon withdrawal occurs, and what the most common alleged offending medications are.

    Methods: Nine electronic databases from January 1966 to December 2016 were systematically searched to identify all relevant studies selected with specific inclusion criteria (a clinical and histopathological diagnosis of DIOLRs, and clearly statement on the systemic offending medication). Read More

    Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus.
    J Oral Sci 2017 ;59(3):373-382
    Eastman Dental Institute, University College London.
    Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing body of evidence regarding the involvement of epithelial-derived cytokines, immune receptors, and costimulatory molecules in the pathobiological processes that promote and sustain OLP. Read More

    Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.
    J Periodontal Res 2017 Sep 12. Epub 2017 Sep 12.
    Department of Periodontology and Synoptic Dentistry, Charité - Medical University Berlin, Berlin, Germany.
    Background And Objectives: In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approach. However, their efficacy is limited. Read More

    Human papillomavirus infection in oral potentially malignant disorders and cancer.
    Arch Oral Biol 2017 Aug 26;83:334-339. Epub 2017 Aug 26.
    Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People's Republic of China. Electronic address:
    Human papillomavirus (HPV) infects keratinocytes in the mucosa or skin, and persistent infection with HPV may lead to premalignant lesions and invasive cancer, especially cervical cancer. It has also been hypothesized that HPV infection is an etiological factor of oral squamous cell carcinoma and oral precancerous disorders such as lichen planus, leukoplakia, and erythroplakia. A high percentage of HPV in oral lesions supports the possible viral contribution, but an association of HPV infection with these lesions remains to be established. Read More

    The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?
    Mol Oral Microbiol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute Seoul National University, Korea.
    Oral lichen planus (OLP) is a variant of LP, a common chronic mucocutaneous inflammatory disease. While cutaneous lesions of LP are self-limiting, OLP lesions are non-remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeutics for this disease. Read More

    Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland.
    Int J Cancer 2017 Aug 31. Epub 2017 Aug 31.
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
    The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. Read More

    Treatment of oral lichen planus using 308-nm excimer laser.
    Dermatol Ther 2017 Aug 23. Epub 2017 Aug 23.
    Department of Dermatology, 404 Hospital of People's Liberation Army, Weihai, Shandong Provence 262200, China.
    Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereby cannot be used in the treatment of OLP. Read More

    Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 23;124(3):e183-e189. Epub 2017 Jun 23.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:
    Objective: Tumor necrosis factor-α (TNF-α) has a role in the progression of the oral lichen planus (OLP). The aim of this meta-analysis study was to evaluate the salivary and serum TNF-α levels in patients with OLP.

    Study Design: We searched in the databases of PubMed/Medline, Science direct, Scopus, Web of Science, and Cochrane Library for studies reported from 1983 to 2016. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Scoring systems for Oral Lichen Planus used by differently experienced raters.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e562-e571. Epub 2017 Sep 1.
    Division of oral medicine and pathology, Dental Science Department, Ospedale Maggiore, 34100, Trieste, Italy,
    Background: Scoring systems have been widely used to evaluate the severity and activity of oral lichen planus (OLP). The aim of the present study was to compare two existing (one modified) scoring systems in the evaluation of OLP severity and correlation with pain. Three differently experienced raters were involved. Read More

    The role of microRNAs in oral lichenoid disorders. Systematic review.
    Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e548-e553. Epub 2017 Sep 1.
    Oral Medicine, Oral and Maxillofacial Pathology. Department of Stomatology II, University of the Basque Country/ EHU, Leioa, 48940 Bizkaia, Spain,
    Background: Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD).

    Material And Methods: A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA. Read More

    Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus.
    Indian J Dermatol 2017 Jul-Aug;62(4):440
    National Skin Centre, Department of Dermatology, Singapore.
    Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. Read More

    Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential.
    Clin Oral Investig 2017 Aug 4. Epub 2017 Aug 4.
    School of Dental Medicine, Department of Oral Medicine, University of Zagreb, Zagreb, Croatia.
    Objectives: The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.

    Materials And Methods: Global protein profiling methods based on liquid chromatography coupled to mass spectrometry (LC-MS) were used, with a special emphasis on evaluation of deregulated extracellular matrix molecules expression, as well as on analyses of IG2F and IGFR2 expression in healthy mucosa, OLP and OSCC tissues by comparative semi-quantitative immunohistochemistry.

    Results: Mass spectrometry-based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and accompanied histologically unaltered tissues, respectively) identified 55 extracellular matrix proteins. Read More

    Impact of Oral Potentially Malignant Disorders on Quality of Life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Queensland, Australia.
    Background: Oral Potentially Malignant Disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the Quality of Life (QoL) of affected patients.

    Methods: Oral Leukoplakia (OL), Oral Lichen Planus (OLP) and Oral Submucous Fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    Efficacy of low-level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
    Background: Low-level laser therapy (LLLT) has been proposed as a potential treatment strategy for the treatment of oral lichen planus (OLP). The aim of this systematic review was to assess the efficacy of LLLT, in comparison with corticosteroid therapy, in the treatment of OLP.

    Materials And Methods: This systematic review aimed to address the following focused question: "Does LLLT yield better clinical outcomes than corticosteroid therapy in the treatment of OLP?" Indexed databases were searched up to and including April 2017. Read More

    Semaphorin4D drives CD8(+) T cell lesional trafficking in oral lichen planus via CXCL9/CXCL10 upregulations in oral keratinocytes.
    J Invest Dermatol 2017 Jul 28. Epub 2017 Jul 28.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:
    Chemokine mediated CD8(+) T cell recruitment is an essential but not well-established event for the persistence of oral lichen planus (OLP). Semaphorin 4D (Sema4D)/CD100 is implicated in immune dysfunction, chemokine modulation and cell migration, which are critical aspects for OLP progression, but its implication in OLP pathogenesis has not been determined. In this study, we sought to explicate the effect of Sema4D on human oral keratinocytes and its capacity to drive CD8(+) T cell lesional trafficking via chemokine modulation. Read More

    Treatment of oral lichen planus. Systematic review and therapeutic guide.
    Med Clin (Barc) 2017 Jul 27. Epub 2017 Jul 27.
    Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Facultad de Medicina, Universidad de Oviedo, Oviedo, España.
    In this systematic review, 55 structured articles on the therapeutic efficacy against pain and clinical signs of oral lichen planus (OLP) were analysed. The literature search was developed according to the criteria of the PRISMA system, selecting the tests performed using one of the following methodological designs: drug (active ingredient) vs. drug in different excipient or concentration, drug vs. Read More

    Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
    Asian Pac J Cancer Prev 2017 07 27;18(7):1947-1951. Epub 2017 Jul 27.
    Oral and Dental Disease Research Center, Department of Oral Medicine, Zahedan University of Medical Science, Zahedan, Iran. Email:
    The aim of present study was to evaluate salivary matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3 and MMP-13 levels in patients with oral lichen planus (OLP) and squamous cell carcinomas (SCC) as well as in healthy controls. Thirty cases of OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) clinically and histopathologically (group A), 30 with oral SCCs (group B), and 30 with no history of oral cancer, other lesions or lichen planus (group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. Unstimulated whole saliva was collected and laboratory measurement of salivary concentration of MMP-1, MMP-2, MMP-3 and MMP-13 was conducted by immuno-sorbent enzyme-linked methods. Read More

    Topical tocopherol for the treatment of ROLP: randomozed,double-blind crossover study - A query.
    Oral Dis 2017 Jul 26. Epub 2017 Jul 26.
    Dept. of Oral medicine and radiology, KMCT Dental college, Manassery, Mukkam, Calicut.
    In a recently published study "Topical tocopherol for treatment of reticular oral lichen planus: a randomized, double-blind, crossover study" (Oral Diseases, January 2017), the authors have assessed the efficacy of topical tocopherol acetate in improving the lesions and oral discomfort of patient's suffering from reticular oral lichen planus comparing it with the results achievable by administering placebo. ((1)) In the study, 34 patients with clinically diagnosed and histologically confirmed ROLP were randomly assigned to two groups, which received first one of two treatments (treatment 1 or 2) for a month, then the other (treatment 2 or 1) for another month, with a two-week washout between them. One treatment contained tocopherol acetate, the other only liquid paraffin. Read More

    Delivering resveratrol on the buccal mucosa using mucoadhesive tablets: a potential treatment strategy for inflammatory oral lesions.
    Curr Drug Deliv 2017 Jul 26. Epub 2017 Jul 26.
    Faculty of Dentistry, Federal University of Juiz de Fora, 36036-900, Juiz de Fora, MG. Brazil.
    Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. Read More

    Integrative analysis of mRNA and miRNA expression profiles in oral lichen planus: preliminary results.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Objective: Oral lichen planus (OLP), a chronic inflammatory disease of unknown etiology, is considered a potentially malignant oral disorder. The aim of the present study was to analyze candidate microRNAs (miRNAs) and genes from patients with OLP and healthy controls (HCs).

    Study Design: Biopsy specimens of the oral mucosa were collected from patients with OLP (n = 9) and from HCs (n = 4). Read More

    Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Oral Medicine and Dentistry, Brigham and Women's Hospital, Harvard School of Dental Medicine, Boston, MA, USA. Electronic address:
    Objectives: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC.

    Study Design: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC. Cultured human keratinocyte lines from benign oral mucosa, OED, and OSCC, as well as a murine model in which OSCC was induced with 4-nitroquinoline-1-oxide, were also evaluated. Read More

    Mucocutaneous Diseases: Oral Lichen Planus, Mucous Membrane Pemphigoid and Pemphigus Vulgaris.
    J Calif Dent Assoc 2016 09;44(9):561-70
    Mucocutaneous diseases affect the oral cavity and can present a diagnostic challenge. They can have systemic involvement, necessitating multidisciplinary management. Frequently, patients will see their general dentists initially for evaluation. Read More

    IL-17A polymorphism and elevated IL-17A serum levels are associated with oral lichen planus.
    Oral Dis 2017 Jul 25. Epub 2017 Jul 25.
    Centro de Ensino e Pesquisa de Laser em Odontologia - CEPLO. Programa de Pós-graduação em Odontologia, Universidade Federal de Pernambuco.
    Objective: The aim of this study was to evaluate the association of IL-17A G197A polymorphism and serum levels with oral lichen planus susceptibility and clinical presentation.

    Subjects And Methods: Eighty three individuals diagnosed with oral lichen planus (OLP) and ninety nine healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL-17A (G197A) genotyping. Read More

    Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 30;124(3):248-252. Epub 2017 May 30.
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:
    Objective: Many patients with oral lichen planus (OLP) report triggers of flares, some of which overlap with triggers of other oral diseases, including oral allergy syndrome and oral contact dermatitis. The purpose of this study was to evaluate the prevalence of commonly reported triggers of OLP flares, their overlap with triggers of other oral diseases, and the potential role of trigger avoidance as a management strategy.

    Study Design: Questionnaire-based survey of 51 patients with biopsy-proven lichen planus with oral involvement seen in an academic dermatology specialty clinic and/or oral pathology clinic between June 2014 and June 2015. Read More

    The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis.
    J Am Dent Assoc 2017 Jul 13. Epub 2017 Jul 13.
    Background: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants.

    Methods: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. Read More

    Incidence of Oral Lichen Planus in Perimenopausal Women: A Cross-sectional Study in Western Uttar Pradesh Population.
    J Midlife Health 2017 Apr-Jun;8(2):70-74
    Department of Oral Medicine and Radiology, Subharti Dental College, Meerut, Uttar Pradesh, India.
    Background: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Salivary levels of interleukin-8 in oral lichen planus and diabetic patients: A biochemical study.
    Dent Res J (Isfahan) 2017 May-Jun;14(3):209-214
    Dentist, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: This study aimed to assess the salivary levels of interleukin-8 (IL-8) in oral lichen planus (OLP) and diabetes mellitus (DM) patients, and OLP + DM patients in comparison with healthy individuals.

    Materials And Methods: This descriptive cross-sectional study was conducted on 75 patients (30 with OLP, 5 with both OLP and DM, 20 with DM and 20 healthy controls). The salivary levels of IL-8 and fasting blood sugar and 2-h postprandial blood glucose levels were measured in all the subjects. Read More

    Thyroid Autoimmunity and Lichen.
    Front Endocrinol (Lausanne) 2017 27;8:146. Epub 2017 Jun 27.
    Department of Clinical and Experimental Medicine - Endocrinology, University of Messina, Messina, Italy.
    Lichen planus (LP) and lichen sclerosus (LS) are cutaneous-mucous diseases with uncertain epidemiology. Current data, which are likely to be underestimated, suggest a prevalence in the general population of 0.1-4% for cutaneous LP, 1. Read More

    Dental patch testing in patients with undifferentiated oral lichen planus.
    Australas J Dermatol 2017 Jul 11. Epub 2017 Jul 11.
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
    Background/objectives: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP. Read More

    Human β2-defensin in oral lichen planus expresses the degree of inflammation.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):77-87
    Department of Medicine and Surgery, University of Insubria, School of Medicine, Unit of Biochemistry, Varese, Italy.
    Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease, were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. Read More

    Autoantibodies to desmogleins 1 and 3 in patients with lichen planus.
    Arch Dermatol Res 2017 Jul 3. Epub 2017 Jul 3.
    Azad University of Medical Sciences, Tehran, Iran.
    There is controversy about the role of autoantibodies against desmoglein 1 and 3 (Dsg1 and 3) in the pathogenesis of lichen planus (LP); the authors planned this study to determine the presence of circulating levels of these antibodies in patients with different types of oral LP and to compare that with cutaneous LP and healthy controls. The enzyme-linked immunosorbent assay test was performed on serum samples of 24 cases of erosive oral LP, 29 cases of reticular oral LP, 30 cases of cutaneous LP and 30 healthy controls. The severity of oral LP was evaluated by Reticulation, Erosion and Ulceration scoring system. Read More

    Biological functions of melatonin in relation to pathogenesis of oral lichen planus.
    Med Hypotheses 2017 Jul 25;104:40-44. Epub 2017 May 25.
    Department of Community Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.
    Oral lichen planus (OLP) is considered as a chronic inflammatory immune-mediated disease causing oral mucosal damage and ulcerations. Accumulated data support the involvement of cell-mediated immune dysfunction in the development of OLP. However, the connection between neuroendocrine system and oral immune response in OLP patients has never been clarified. Read More

    Linear IgA bullous dermatosis mimicking oral lichen planus.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):360-361
    Texas A&M Health Science Center College of Medicine (Shah, Parekh) and Department of Dermatology, Scott & White Memorial Hospital (Shah, Mohr, Parekh), Temple, Texas.
    Linear IgA bullous dermatosis (LABD) is an autoimmune disease characterized by blisters on the skin and mucous membranes. Polycyclic, grouped bullae on cutaneous skin are the most characteristic clinical feature of LABD. Lesions are often indistinguishable from bullous pemphigoid or may resemble dermatitis herpetiformis. Read More

    Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of Oral Lichen Planus.
    Photodiagnosis Photodyn Ther 2017 Jun 29. Epub 2017 Jun 29.
    Department of Oral and Maxillofacial Medicine, Guilan University of Medical Sciences, Rasht, Iran.
    Background: Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease.

    Aim: The present study compared the clinical effects of the photodynamic therapy and dexamethasone mouthwash in the treatment of oral lichen planus lesions. Read More

    Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis.
    BMC Oral Health 2017 Jun 29;17(1):103. Epub 2017 Jun 29.
    Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 20 Noerre Allé, DK-2200, Copenhagen N, Denmark.
    Background: To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.

    Methods: Forty-nine patients (42 women, aged 61.0 ± 10. Read More

    No detection of Merkel cell polyomavirus in oral lichen planus: Results of a preliminary study in a French cohort of patients.
    J Med Virol 2017 Nov 25;89(11):2055-2057. Epub 2017 Jul 25.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
    Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte-mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients with different forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Read More

    Lichenoid Dysplasia-A Case Report with a Review of Differential Diagnosis.
    J Clin Diagn Res 2017 May 1;11(5):ZD01-ZD02. Epub 2017 May 1.
    Associate Professor and Head, Department of Oral Medicine and Radiology, Christian Dental College, CMC, Ludhiana, Punjab, India.
    Lichenoid Dysplasia (LD) is often regarded as lichen planus with dysplastic features, as it mimics lichen planus clinically and histologically. Although it has been confirmed that these two entities are entirely different with not so similar etiopathogenesis, yet the confusion still exists. The separation between the two is of utmost importance as each of them has their own prognosis and treatment plan. Read More

    Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis of Lichen Planus and Lichenoid Mucositis.
    J Clin Diagn Res 2017 May 1;11(5):ZC84-ZC86. Epub 2017 May 1.
    Postgraduate Student, Department of Oral Pathology, Adhiparasakthi Dental College and Hospital, Chennai, Tamil Nadu, India.
    Introduction: Memory T cells have the ability to survive in a quiescent state for longer periods and are responsible for the rapid responses on subsequent exposure to antigen. Analyzing memory T cells in Oral Lichen planus (OLP) and Lichenoid Mucositis (LM) suggest that these cells may play a role in the immunopathogenic mechanisms.

    Aim: To identify and evaluate Memory T cells in Lichen Planus (LP), Lichenoid Mucositis (LM) and Normal Mucosa (NM) using CD45RO monoclonal antibody immunohistochemically. Read More

    Unilateral Blaschkoian Lichen Planus: A Series of Cases with Review of literature.
    J Clin Diagn Res 2017 May 1;11(5):WR01-WR04. Epub 2017 May 1.
    Junior Resident, Department of Dermatology, Venereology and Leprology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
    A number of congenital and acquired dermatological diseases are known to follow lines of Blaschko. Lichen Planus (LP), commonly acquired inflammatory dermatosis, presents with various morphological forms but Blaschkoian variant is very less published in literature. We herein report a case series of six patients of various age groups with Blaschkoian LP, without any underlying predisposing factors. Read More

    A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma.
    Medicine (Baltimore) 2017 Jun;96(25):e7012
    Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
    Background: In this study, the molecular mechanisms underlying malignant transformation from oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) were examined.

    Methods: High-throughput sequencing of long noncoding RNAs (lncRNAs) and mRNAs of normal subjects and patients with OLP and OSCC was conducted. RNA-seq reads were mapped, lncRNA and mRNA transcripts were assembled, and expression levels were estimated. Read More

    Swiss Dent J 2017 ;127(6):538-539
    Clinique universitaire de chirurgie maxillo-faciale, Hôpital de l’Ile, Hôpital universitaire de Berne, Bern, Switzerland.
    Oral lichen planus is a relatively common T-cell mediated inflammatory disease with potential malignant transformation. It may present itself with pain and oral lesions such as ulcers and Wickham’s striae. Treatment includes topical corticosteroids, preferably Clobetasol, immunosuppressive drugs and retinoids. Read More

    Oral mucous membrane pemphigoid associated with hypothyroidism: A retrospective study and a case report.
    Quintessence Int 2017 ;48(7):569-573
    Objective: The purpose of the study was to evaluate the relationship between mucous membrane pemphigoid and a state of hypothyroidism. The study included analysis of the dental charts of 40 subjects with clinically and histologically confirmed diagnosis of mucous membrane pemphigoid and 35 age- and gender-matched subjects, from the same clinic, with no diagnosis of vesiculo-ulcerative lesions.

    Results: Thirteen subjects from the pemphigoid group (32%) had a hypothyroid condition, compared to four subjects (11%) from the control group (P = . Read More

    Can atrophic erosive oral lichen planus promote cardiovascular diseases? A population-based study.
    Oral Dis 2017 Jun 19. Epub 2017 Jun 19.
    Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Turin, Italy.
    Objectives: Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVDs). The oral manifestations can be divided into white hyperkeratotic lesions (WL) and atrophic erosive lesions (RL). The aim of this report was to compare the presence of CVDs between patients affected by WL or RL, to test the hypothesis that RL are associated with an increased incidence of CVDs. Read More

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