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    Lichen planus: molecular pathway and clinical implications in oral disorders.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):135-138
    Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Naples, Italy.
    Stem cells play a role in many mucosal disorders characterised by abnormal proliferation and differentiation of keratinocytes, such as oral lichen planus (OLP). In OLP there were changes in stem cell markers as component of integrin complexes α6 and β1 integrin increased along with increase of melanoma-associated chondroitin sulphate proteoglycan (MCSP) and decreased of notch1 (N1) and keratin 15 (K15). Stem cell marker expression may be altered by pathological signalling in these lesions. Read More

    Psychiatric disorders in oral lichen planus: a preliminary case control study.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):97-100
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    The aim of this study was to evaluate the prevalence of psychiatric symptoms in patients with oral lichen planus (OLP) compared to a control group. Eleven patients (mean age 65.2 years-old), with diagnosis of OLP and 13 controls (mean age 64. Read More

    Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus.
    Clin Exp Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Davis Medical Center, University of California-Davis, Sacramento, CA, USA.
    Background: Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy.

    Aim: To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa. Read More

    Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):701-710. Epub 2017 Nov 29.
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan.
    Hepatitis C virus (HCV) infection is frequently associated with various extrahepatic manifestations, such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one such extrahepatic manifestation of HCV infection. Recently, direct-acting antivirals (DAA) have proved to be highly effective and safe for the eradication of HCV. Read More

    Increased infiltration of CD11 c/CD123dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 18. Epub 2017 Dec 18.
    Department of Oral Mucosal Diseases, Ninth People's Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China; National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:
    Objective: Investigation of dendritic cell (DC) subsets and expression patterns of Toll-like receptors (TLRs) was conducted to understand the pathogenesis in oral lichen planus (OLP).

    Study Design: Blood, OLP lesion, and control samples were collected. Four DC subsets (CD11cCD123myeloid DC1 [mDC1], CD141mDC2, CD11cCD123plasmacytoid DC [pDC], and CD1aCD207Langerhans cells [LC]) were investigated via flow cytometry (FCM) and immunohistochemical staining. Read More

    Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.
    J Formos Med Assoc 2018 Feb 7. Epub 2018 Feb 7.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Efficacy of photodynamic therapy and low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus.
    Photodiagnosis Photodyn Ther 2018 Feb 4. Epub 2018 Feb 4.
    Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Electronic address:
    Background: The efficacy of photodynamic therapy (PDT) and low level laser therapy (LLLT) in the treatment of oral lichen planus (OLP) is debatable. The aim of this study was to compare the effects of PDT and LLLT with topical corticosteroid application in the treatment of erosive-atrophic OLP.

    Materials And Methods: Forty-five adult patients with erosive-atrophic biopsy-proven OLP on the tongue or buccal mucosa (size ≤3 cm) were randomly divided into three groups. Read More

    The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus.
    J Oral Pathol Med 2018 Feb 7. Epub 2018 Feb 7.
    Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China.
    Background: The present study was to investigate association and potentially destructive role of Th9/IL-9 and their synergistic interaction with Th17 cells in elevating MMP9 production in local lesions of oral lichen planus (OLP) patients.

    Methods: Oral mucosal tissues were obtained from OLP patients and healthy controls (HC) and then divided into an epithelial part (EP) or a lamina propria part (LP). Both EP and LP subsets were assessed for IL-9 and MMP9 mRNA levels by real-time quantitative PCR (qPCR). Read More

    Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus.
    Dermatol Ther 2018 Feb 6. Epub 2018 Feb 6.
    Microbiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    The aim of this study was to evaluate the safety and efficacy of Bacillus Calmette-Guerin, polysaccharide nucleic acid (BCG-PSN) therapy in the treatment of oral and cutaneous LP. Twenty-four LP patients were included in this study and classified randomly into; Oral LP group (OLP), 11 patients and Cutaneous LP group (CLP), 13 patients. All patients received intradermal injections of BCG-PSN, twice weekly for three weeks. Read More

    Oral potentially malignant disorders: risk of progression to malignancy.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    UWA Dental School, The University of Western Australia, Nedlands, Australia.
    Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Read More

    Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):456-457
    Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.
    Context: The malignant transformation potential of oral lichen planus (OLP) and related lesions is a subject of great controversy.

    Aim: The aim of this study was to compare the expression of proteins related to apoptosis and tumour suppressor gene processes in OLP, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD).

    Materials And Methods: The immunohistochemical study was carried out to investigate the expressions of survivin and p53 in a total of 30 lesional biopsy specimens - 10 cases each of OLP, OLR and OLD. Read More

    Estimation of silver nucleolar organizer regions in oral lichen planus, oral lichenoid reactions and oral lichenoid dysplasia.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):454
    Department of Oral Pathology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
    Aims And Objective: (1) To study the clinical and histological features of oral lichen planus, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD). (2) To estimate and compare the silver nucleolar organizer regions in OLR and OLD.

    Materials And Methods: A total of 40 biopsies were studied; sections were divided as study group, which consists of OLP, OLR and OLD each of 10 cases and 10 biopsies of normal oral mucosa as control group. Read More

    Evaluation of oxidative stress markers in oral lichen planus.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):387-393
    Department of Oral Pathology, Azeezia College of Dental Sciences and Research, Kollam, Kerala, India.
    Background: Lichen planus (LP) is a chronic, inflammatory disease that affects the skin, mucous membrane, scalp and nails that frequently involves the oral mucosa. Oxidative stress reflects an imbalance between the production of reactive oxygen species and the biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. It has been suggested that oxidative stress may play a role in the pathogenesis of LP. Read More

    Salivary proteomics in lichen planus: A relationship with pathogenesis?
    Oral Dis 2018 Jan 30. Epub 2018 Jan 30.
    Department of Stomatology School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
    Objectives: Oral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocytes pathways induce apoptosis with an increase of Th1 and Th17 subtypes cells, triggered by the release of cytokines; This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease.

    Material And Methods: Proteins differentially expressed by oral lichen planus and healthy controls were screened using mass spectrometry; the proteins found in oral lichen planus were subjected to bioinformatics analysis, including gene ontology and string networks analysis. Read More

    Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients.
    Arch Dermatol Res 2018 Jan 24. Epub 2018 Jan 24.
    Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
    Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cells against basal epithelial cells. MicroRNAs (MiRNAs) are short non-coding RNA that plays critical role in gene expression at post-transcriptional levels. Much evidence showed that miRNAs play an important role in regulating immune response and cancer development. Read More

    Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus.
    Clin Exp Otorhinolaryngol 2018 Jan 26. Epub 2018 Jan 26.
    Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University Medical Center, Seoul, Korea.
    Objectives: To examine the factors which affect the improvement or the recurrence of disease after intralesional steroid injection in patients with oral lichen planus (OLP).

    Methods: Sixty-two patients diagnosed as OLP were treated with intralesion corticosteroid injection. To evaluate the objective severity of OLP, total severity score of OLP was assessed. Read More

    Psychopathological profile and quality of life of patients with oral lichen planus.
    J Appl Oral Sci 2018 Jan 18;26:e20170146. Epub 2018 Jan 18.
    Wroclaw Medical University, Department of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw, Poland.
    Oral lichen planus (OLP) is a chronic, multifocal, sometimes painful, inflammatory disease of the oral mucosa. OLP can predispose development of psycho-emotional disorders. Until now, the relationship between the severity of lichen planus and the psychological profile of patients (psychological well-being, perceived stress and pain coping strategies) has never been studied. Read More

    Squamous cell carcinoma from oral lichen planus: a case report of a lesion with 28 years of evolution.
    J Korean Assoc Oral Maxillofac Surg 2017 Dec 27;43(Suppl 1):S14-S18. Epub 2017 Dec 27.
    Department of Dentistry, Sagrado Coração University, Bauru, Brazil.
    Lichen planus (LP) is a relatively common mucocutaneous disease with autoimmune etiology. Considering its malignancy potential, it is important to define the correct diagnosis, treatment, and clinical follow-up for patients with LP so that the disease is not diagnosed late, thus hindering the chances of curing the disease. This study aims to describe a clinical case of oral squamous cell carcinoma, potentially originated from LP. Read More

    Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review.
    J Oral Pathol Med 2018 Jan 19. Epub 2018 Jan 19.
    Department of Oral Medicine and Diagnostic Sciences, AlFarabi Colleges, Riyadh, Saudi Arabia.
    Background: The aim of this study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus (OLP).

    Materials And Methods: PubMed/MEDLINE, Scopus, and ISI Web of knowledge were searched until July 2017, using the following keywords: OLP, erosive lichen planus, lichen planus, and PDT.

    Results: Five clinical studies were included. Read More

    Association between hepatitis C infection in Thai patients with oral lichen planus: A case-control study.
    J Investig Clin Dent 2018 Jan 18. Epub 2018 Jan 18.
    Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
    Aim: The aim of the present study was to investigate the prevalence of hepatitis C virus (HCV) infection and evaluate liver enzyme levels in patients from upper northern Thailand with oral lichen planus (OLP).

    Methods: A case-control study of 101 patients with OLP and 101 patients without OLP was conducted. Peripheral blood was taken from each patient and screened for anti-HCV antibody using immunochromatography. Read More

    Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
    Background: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. Read More

    LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus.
    Sci Rep 2018 Jan 15;8(1):763. Epub 2018 Jan 15.
    Department of Stomatology, Shanxi Medical University, Taiyuan, Shanxi, China.
    The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. Read More

    Dysplasia Should Not Be Ignored in Lichenoid Mucositis.
    J Dent Res 2018 Jan 1:22034517748639. Epub 2018 Jan 1.
    1 Faculty of Dentistry, the University of British Columbia, Vancouver, BC, Canada.
    Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. Read More

    Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
    Environ Toxicol 2018 Jan 12. Epub 2018 Jan 12.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Read More

    Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
    J Dermatolog Treat 2018 Jan 31:1-7. Epub 2018 Jan 31.
    a Department of Neurosciences, Reproductive and Odontostomatological Sciences , University Federico II of Naples , Naples , Italy.
    Objectives: We sought to determine the efficacy of psychotropic drug in the management of BMS-like oral symptoms in patients with reticular oral lichen planus (R-OLP) refractory to conventional therapies, and its impact on anxious and depressive symptoms.

    Materials And Methods: We enrolled 28 cases of symptomatic R-OLP. The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2). Read More

    Biomolecules in the treatment of lichen planus refractory to corticosteroid therapy: Clinical and histopathological assessment.
    Ann Anat 2018 Jan 1;216:159-163. Epub 2018 Jan 1.
    University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain; BTI Biotechnology Institute, Vitoria, Spain. Electronic address:
    Background: Local deficit of several biomolecules have been described in oral lichen planus (OLP). Such a deficit impairs cellular functions and cell-matrix communication.

    Purpose: Assess the efficacy of the local application of autologous biomolecules in the treatment of erosive OLP. Read More

    Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus.
    Oral Dis 2018 Jan 3. Epub 2018 Jan 3.
    Department of Surgical Sciences, CIR-Dental School, University of Turin, Turin, Italy.
    Objective: To perform a randomized, placebo-controlled, double-blind study, with a follow-up period of 6 months, for the use of topical clobetasol in cases of symptomatic oral lichen planus (OLP).

    Subjects And Methods: Thirty-two participants were analyzed, with the aims of: (I) to compare the usefulness of topically applied clobetasol propionate 0.05% (mixed with 4% hydroxyethyl cellulose gel) and 4% hydroxyethyl cellulose gel alone (considered as placebo) in the management of OLP; (II) to describe which of them is quicker in decreasing signs and reported symptoms, and (III) which is able to give the proper longer remission in the follow-up. Read More

    Direct Immunofluorescence as a Helpful Tool for the Differential Diagnosis of Oral Lichen Planus and Oral Lichenoid Lesions.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
    A great number of lichenoid lesions have overlapping clinicopathological features, so the use of adjunct tests to establish definitive diagnosis is recommended for correct management and prognosis of the lesions. In this context, direct immunofluorescence (DIF) can be a useful tool. Thus, this study aimed to characterize the clinical, histopathological, and DIF pattern in patients with oral lichen planus (OLP) and patients with oral lichenoid lesions (OLLs). Read More

    Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients.
    J Formos Med Assoc 2017 Dec 29. Epub 2017 Dec 29.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Approximately 27% of erosive oral lichen planus (EOLP) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or EOLP itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or autoantibodies-negative EOLP patients (GPCA/EOLP and Abs/EOLP patients).

    Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 41 GPCA/EOLP patients, 198 Abs/EOLP patients, and 184 healthy control subjects. Read More

    Intraepithelial CD8 (+) Lymphocytes as a Predictive Diagnostic Biomarker for the Remission of Oral Lichen Planus.
    Hum Pathol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
    Oral lichen planus (OLP) is an autoimmune inflammatory disease of the oral mucosa whose etiology remains unknown. Moreover, the possibility of OLP being a premalignant change is under debate. Various types of immune cells infiltrate the OLP lesion and affect its clinicopathological features. Read More

    Evaluation of the content quality of websites for recurrent aphthous ulcers and oral lichen planus.
    BMC Oral Health 2017 12 29;17(1):170. Epub 2017 Dec 29.
    Department of Oral Medicine, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, China.
    Background: The Internet is one of the most popular resources for people to obtain medical information; however, only a limited number of studies have reported the quality of the available health information related to oral mucosal diseases. The present study aimed to evaluate the quality of information on websites for recurrent aphthous ulcers (RAU) and oral lichen planus (OLP), in both Chinese and English.

    Methods: Common search engines, BaiDu, Google, and Yahoo in Chinese; and Bing, Google, and Yahoo in English were used to identify websites providing content related to the oral mucosal diseases. Read More

    Psychological factors in oral mucosal and orofacial pain conditions.
    Eur J Dent 2017 Oct-Dec;11(4):548-552
    Department of Oral Medicine and Oral Surgery, Faculty of Dentistry,University of Science and Technology, Irbid, Jordan.
    The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions (namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders) with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients. A literature search restricted to reports with highest relevance to the selected mucosal and orofacial pain conditions was carried out to retrieve data. Read More

    Rapid detection of Candida albicans in oral exfoliative cytology samples by loop-mediated isothermal amplification.
    J Oral Sci 2017 ;59(4):541-547
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry.
    Loop-mediated isothermal amplification (LAMP) rapidly amplifies DNA under isothermal conditions. The aim of this study was to detect Candida albicans and compare the positivity rate in the LAMP reaction with that of conventional methods for oral exfoliative cytology (EC) samples. Sixty-eight EC samples from 53 patients were subjected to LAMP analysis. Read More

    Evaluation of the miRNA-146a and miRNA-155 Expression Levels in Patients with Oral Lichen Planus.
    Iran J Immunol 2017 Dec;14(4):316-324
    Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
    Background: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status.

    Objective: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa.

    Methods: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were recruited in this case-control study. Read More

    Differential expression of STAT-3 in subtypes of oral lichen planus: a preliminary study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 14;125(3):236-243.e1. Epub 2017 Nov 14.
    Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:
    Objective: This study aimed to examine the expression of signaling transduction proteins and their possible correlation with different clinical subtypes of oral lichen planus (OLP).

    Study Design: We examined the immunoexpression and phosphorylation status of 21 signaling transduction proteins of OLP (n = 10) and normal groups (n = 8) using PathScan analysis. Using immunohistochemistry, we detected expression of STAT-3 and p38 MAPK in tissues of OLP (n = 40) and normal controls (n = 10). Read More

    P-glycoprotein expression in oral lichen planus.
    Braz Oral Res 2017 Dec 18;31:e95. Epub 2017 Dec 18.
    West Bengal State University, Department of Physiology, Kolkata, India.
    Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually overexpressed with chemotherapy, leading to chemoresistance. OLP, a lesion with carcinogenic potency, is broadly classified into the asymptomatic reticular form and the aggressive erosive form. Read More

    The measurement of serum TNF-α levels in patients with lichen planus.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):85-88
    Department of Dermatology, Ufuk University, Ankara, Turkey.
    Background: Lichen planus is a common mucocutaneous inflammatory skin disease with a multifactorial etiology. Cytokines play a key role in lichen planus pathogenesis. This study investigates the relationship between disease severity and levels of tumor necrosis factor-α (TNF-α), which is considered a primary cytokine that initiates cytotoxicity. Read More

    Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation.
    Pathol Res Pract 2018 Feb 10;214(2):296-302. Epub 2017 Nov 10.
    College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China. Electronic address:
    Objective: The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP).

    Study Design: The expression of p16 and HPV16/18(E6) in 40 cases of OLP and 6 MT-OLP was assessed by immunohistochemical staining. Twenty four cases of normal oral mucosa were used as controls. Read More

    "Omics" in oral cancer: New approaches for biomarker discovery.
    Arch Oral Biol 2018 Mar 8;87:15-34. Epub 2017 Dec 8.
    School of Medical Science and Technology, IIT Kharagpur, India. Electronic address:
    Objectives: In this review paper, we explored the application of "omics" approaches in the study of oral cancer (OC). It will provide a better understanding of how "omics" approaches may lead to novel biomarker molecules or molecular signatures with potential value in clinical practice. A future direction of "omics"-driven research in OC is also discussed. Read More

    New evidence of connections between increased O-GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus.
    Clin Exp Immunol 2017 Dec 16. Epub 2017 Dec 16.
    Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.
    Oral lichen planus (OLP) is considered a chronic inflammatory immune-mediated disease of the oral mucosa. Immunopathogenesis of OLP is thought to be associated with cell-mediated immune dysregulation. O-GlcNAcylation is a form of reversible glycosylation. Read More

    Molecular Classification of Autofluorescence Excision Margins in Oral Potentially Malignant Disorders.
    Oral Dis 2017 Dec 14. Epub 2017 Dec 14.
    Australian Centre for Oral Oncology Research & Education, UWA Dental School, University of Western Australia, Nedlands, WA, Australia.
    Objective: To define molecular differences between autofluorescence and white light defined excision margins in oral potentially malignant disorders (OPMD) using transcriptome expression profiles.

    Materials And Methods: Excisional biopsy specimens were taken from 11 patients at three different sites for each lesion: centre, white light margin, and autofluorescence margin. The lesions were diagnosed histopathologically as oral epithelial dysplasia, oral lichenoid dysplasia, oral lichen planus or other. Read More

    Vulvar lichen planus pemphigoides.
    Int J Womens Dermatol 2017 Dec 20;3(4):225-227. Epub 2017 Aug 20.
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH.
    Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. Read More

    A Review of the Effectiveness and Side-Effects of Fluocinolone Acetonide 0.1% in the Treatment of Oral Mucosal Diseases.
    Acta Stomatol Croat 2017 Sep;51(3):240-247
    Oral Medicine Department, Faculty of Dentistry Chulalongkorn University Bangkok, Thailand.
    Topical steroids have been widely used in the treatment of symptomatic oral lesions to reduce pain and inflammation. Potent topical steroids such as clobetasol propionate, fluocinolone acetonide (FA), and fluocinonide have been widely used in the treatment of severe oral mucosal lesions. Many reports have demonstrated that these steroids were effective in treating oral lesions with only minor side-effects. Read More

    Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review.
    Photodermatol Photoimmunol Photomed 2017 Dec 9. Epub 2017 Dec 9.
    Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.
    Background: The aim of this systematic review was to assess the efficacy of photodynamic therapy (PDT) in the treatment of symptomatic oral lichen planus (OLP).

    Methods: This systematic review aimed to address the following focused question: "Is PDT effective in the treatment of symptomatic OLP?" Indexed databases such as MEDLINE, EMBASE, and CENTRAL were searched up to and including August 2017.

    Results: Six clinical studies were included. Read More

    Association of Oral Lichen Planus and Electrocardiographic P-Wave Dispersion - An Original Research.
    Braz Dent J 2017 Nov-Dec;28(6):699-703
    Department of General Medicine, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
    Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Read More

    Oral Manifestation in Patients diagnosed with Dermatological Diseases.
    J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.
    Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.
    Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

    Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

    Micronucleus Assay: An Early Diagnostic Tool to Assess Genotoxic Changes in Patients with Tobacco Use, Oral Leukoplakia and Oral Submucous Fibrosis.
    J Clin Diagn Res 2017 Sep 1;11(9):ZC28-ZC32. Epub 2017 Sep 1.
    Medical Research Scientist, Jorhat Medical College and Hospital, Barbheta, Jorhat, Assam, India.
    Introduction: Micronuclei (MNi) are acentric chromatid or chromosome fragments produced via genetic damage through genotoxic agents contained in tobacco and betel nut. Evidently, the various Oral Potentially Malignant Disorders (OPMDs) like oral lichen Planus, oral leukoplakia and Oral Submucous Fibrosis (OSMF) demonstrate MNi, as a substantiation of genetic damage. As these changes can be easily appreciated in oral exfoliated cells, an exfoliated cell based MNi assay might be utilized as handy and non invasive biomonitoring tool for gauging the genetic damage and hence the propensity for malignant transformation in OPMDs. Read More

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