5,161 results match your criteria Oral Lichen Planus

Oral Health, Antimicrobials and Care for Patients With Chronic Oral Diseases - A Review of Knowledge and Treatment Strategies.

Front Oral Health 2022 7;3:866695. Epub 2022 Jun 7.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom.

Periodontal and chronic oral mucosal diseases are significant life impacting conditions which may co-exist and synergistically act to cause more severe and widespread oral pathology with enhanced challenges in effective management. Clinicians regularly observe these effects and struggle to effectively manage both problems in many patients. There is limited understanding of many basic and applied scientific elements underpinning potentially shared aetiopathological features and management. Read More

View Article and Full-Text PDF

MiR-155-5p modulates inflammatory phenotype of activated oral lichen-planus-associated-fibroblasts by targeting SOCS1.

Mol Biol Rep 2022 Jun 22. Epub 2022 Jun 22.

Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.

Background: Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease. Cytokines are closely associated with OLP development. In addition to immune cells, fibroblasts have been reported to induce regional inflammation. Read More

View Article and Full-Text PDF

Clinical responses of patients with systemic diseases to the photodynamic therapy of oral lichen planus.

Photodiagnosis Photodyn Ther 2022 Jun 19:102972. Epub 2022 Jun 19.

Oral Medicine, Periodontology, Diagnosis and Oral Radiology Department, Faculty of Dentistry, Mansoura University, Egypt, 33516.

Background:  Oral lichen planus (OLP) is a chronic disease commonly detected in older aged patients with female predominance. Treatment of OLP in diabetic and hypertensive patients usually shows some difficulties which require a more safe and effective treatment modality such as Photodynamic therapy (PDT). The current study aims to evaluate the role of PDT in treating OLP in diabetic and hypertensive patients. Read More

View Article and Full-Text PDF

Otolaryngology adverse events following COVID-19 vaccines.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):4113-4116

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Objective: Since the outbreak of COVID-19 pandemic, the international scientific community aimed at developing a vaccine to protect against the infection and prevent serious forms of the disease. To date, various adverse events of COVID-19 vaccines have been reported, mostly mild to moderate.

Materials And Methods: In this short communication, we reviewed available literature and described the most frequent otolaryngology adverse events reported after COVID-19 vaccination. Read More

View Article and Full-Text PDF

Prevalence of Epstein-Barr Virus in Oral Lichen Planus in Korea.

Ann Dermatol 2022 Jun 20;34(3):228-230. Epub 2022 May 20.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

View Article and Full-Text PDF

Oral Chronic Graft-Versus-Host Disease.

Front Oral Health 2022 20;3:903154. Epub 2022 May 20.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, United States.

Chronic oral graft-versus-host disease (cGVHD) is a complex, frequent, and highly impactful complication of allogeneic hematopoietic cell transplantation (alloHCT). It represents the leading cause of morbidity and mortality in long-term alloHCT survivors. cGVHD can affect almost any visceral organ system and commonly affects the skin, eyes and mouth, manifesting with signs and symptoms similar to other known immune-mediated and autoimmune diseases. Read More

View Article and Full-Text PDF


Linda L Cheng

J Evid Based Dent Pract 2022 06 16;22(2):101717. Epub 2022 Mar 16.

Article Title And Bibliographic Information: González-Moles MÁ, Ramos-García P, Warnakulasuriya S. An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review. Oral Dis. Read More

View Article and Full-Text PDF

Salivary expression of lncRNA DQ786243 and IL-17 in oral lichen planus: case-control study.

BMC Oral Health 2022 Jun 18;22(1):240. Epub 2022 Jun 18.

Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, 11 El-Saraya Street, Manial, Cairo, 11553, Egypt.

Background: A growing number of studies has investigated IL-17 in OLP. However, its exact role and interactions are not fully determined. In addition, the literature investigating its salivary expression is limited. Read More

View Article and Full-Text PDF

Clinicopathological Study of Biopsied Tongue Lesions Among 5284 Dental Outpatients in Southern Iran.

J Maxillofac Oral Surg 2022 Jun 23;21(2):307-311. Epub 2020 Sep 23.

Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Some studies have shown a high incidence of oral cancer among tongue biopsy specimens. This study aimed to determine the prevalence and distribution of tongue biopsied lesions in an Iranian population.

Methods: In this retrospective study, data from 5284 oral biopsy reports over a 22-year period (1996-2017) were evaluated regarding the type of lesions, location and patient's age and gender. Read More

View Article and Full-Text PDF

Effectiveness of methylene blue photosensitizers compared to that of corticosteroids in the management of oral lichen planus: a systematic review and meta-analysis.

J Dent Anesth Pain Med 2022 Jun 27;22(3):175-186. Epub 2022 May 27.

Department of Oral Medicine and Radiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India.

This study aimed to systematically review the effectiveness of methylene blue (MB) photosensitizers in the management of symptomatic oral lichen planus (OLP). Electronic online databases and manual searches were performed for randomized controlled trials (RCTs) published in English between January 2010 and February 2022. RCTs comparing photodynamic therapy (PDT) and corticosteroid therapy at baseline and follow-up period were identified. Read More

View Article and Full-Text PDF

Evaluation of the Distribution of in Patients with Dysplastic and Nondysplastic Oral Lichen Planus Lesions.

Biomed Res Int 2022 1;2022:8100352. Epub 2022 Jun 1.

Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: This study is aimed at identifying and determining the distribution of isolated species in patients with dysplastic and nondysplastic oral lichen planus (OLP) lesions in comparison with those of healthy controls. . This study includes patients with OLP, aged (more than 18 years old), who have had informed consent. Read More

View Article and Full-Text PDF

An improved scoring system for monitoring oral lichen planus: A preliminary clinical study.

Oral Dis 2022 Jun 10. Epub 2022 Jun 10.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Objectives: To design an improved oral lichen planus (OLP) scoring system, which can be widely applied.

Subjects And Methods: A new scoring system that took reticulation, hyperemia and ulceration (RHU) into account, named as RHU scoring system, was designed for OLP patients' management. The patients were also scored for the reticulation/erythema/ulcer (REU) scoring system, physician global assessment (PGA), numerical rating scale (NRS) and Oral Health Impact Profile-14 (OHIP-14). Read More

View Article and Full-Text PDF

Severe childhood lichen planus pemphigoides after hepatitis A vaccination.

Skin Health Dis 2022 Jun 19;2(2):e94. Epub 2022 Jan 19.

Department of Dermatology Farhat Hached Hospital of Sousse Sousse Tunisia.

Background: Lichen planus (LP) pemphigoides (LPP) is a very rare autoimmune bullous disorder, that is, exceptional in children.

Case Report: We report a case of LP pemphigoides with severe cutaneous and mucosal involvement in an 8-year-old girl who consulted for multiple vesicular and bullous lesions associated with shiny erythematous-purple plaques. The eruption occurred 2 months after vaccination against hepatitis A virus. Read More

View Article and Full-Text PDF

Characteristics of Oral Mucosal Lesions and Their Association With Socioeconomic Status and Systemic Health: A Cross-Sectional Study of Consecutively Collected Oral Medicine Clinic Data in a Remote Rural Area of China.

Front Public Health 2022 23;10:897814. Epub 2022 May 23.

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: Epidemiological data of oral mucosal lesions (OMLs) are required to develop practical oral care policies. However, limited data are available for rural areas in China. We aimed to estimate the spectrum and frequency of OMLs and to identify their associated socioeconomic status (SES) and systemic health in a remote rural area in Yunnan, China. Read More

View Article and Full-Text PDF

Oral Lichen Planus Treated With Plasma Rich in Growth Factors.

Cutis 2022 Mar;109(3):163-166

University Institute for Regenerative Medicine and Oral Implantology (UPV/EHU-Fundación Eduardo Anitua), Vitoria-Gasteiz, Álava, Spain. Dr. Eguia also is from the University of the Basque Country UPV/EHU, Leioa, Vizcaya, Spain. Dr. Alkhraisat also is from BTI Biotechnology Institute, Vitoria-Gasteiz. Dr. Anitua is the Scientific Director of BTI Biotechnology Institute and the President of Eduardo Anitua Foundation. Drs. Eguia and Piñas are researchers at the Eduardo Anitua Foundation. Dr. Piñas also served as a speaker for BTI Biotechnology Institute. Dr. Alkhraisat is a researcher at BTI Biotechnology Institute.

The use of plasma rich in growth factors (PRGF) is a treatment for erosive oral lichen planus (OLP) resistant to steroid therapy. An anonymous database at a clinical center was reviewed to collect demographic data, lesion type, treatment protocol, number of infiltrations, pain score, and healing time of the lesions. Fifteen patients were included in this study. Read More

View Article and Full-Text PDF

1,25(OH) D blocks IFNβ production through regulating STING in epithelial layer of oral lichen planus.

J Cell Mol Med 2022 May 29. Epub 2022 May 29.

Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, China.

Stimulator of interferon genes (STING) is reported to exert vital functions in inflammatory responses and autoimmune diseases. Nevertheless, the status and roles of STING in oral lichen planus (OLP) remain elusive. Here, we state that STING and its downstream cytokine interferon-β (IFNβ) expression is boosted in the oral keratinocytes from patients suffering OLP in comparison with those from healthy participants. Read More

View Article and Full-Text PDF

[The study of microbiota in patients with bullous lesions of the oral mucosa].

Stomatologiia (Mosk) 2022 ;101(3):18-21

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.

The Aim Of The Study: The study by the method of tissue polymerase chain reaction of the species composition of the microbiota of lesions of the oral mucosa in patients with bullous lesions.

Material And Methods: Biopsy specimens of the oral mucosa of 51 patients were studied by the polymerase chain reaction method, of which 14 patients with pemphigus vulgaris, 17 patients with pemphigoid bullosa, and 20 patients with the bullous form of ruber lichen planus. 4 types of microorganisms have been identified - Fusobacterium, Streptococcus pneumoniae, Candida albicans, Ureaplasma spp. Read More

View Article and Full-Text PDF

Diagnostic Accuracy of High-Grade Intraepithelial Papillary Capillary Loops by Narrow Band Imaging for Early Detection of Oral Malignancy: A Cross-Sectional Clinicopathological Imaging Study.

Cancers (Basel) 2022 May 13;14(10). Epub 2022 May 13.

Department of Oral and Maxillofacial Reconstructive Surgery, Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan.

This study aimed to clarify the advantages and disadvantages of conventional visual inspection (CVI), endoscopic white light imaging (WLI), and narrow-band imaging (NBI) and to examine the diagnostic accuracy of intraepithelial papillary capillary loops (IPCL) for the detection of oral squamous cell carcinoma (OSCC). This cross-sectional study included 60 participants with oral mucosal diseases suspected of having oral potentially malignant disorders (OPMDs) or OSCC. The patients underwent CVI, WLI, NBI, and incisional biopsy. Read More

View Article and Full-Text PDF

Oral Microbiome Research on Oral Lichen Planus: Current Findings and Perspectives.

Biology (Basel) 2022 May 9;11(5). Epub 2022 May 9.

Department of Oral Biochemistry, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju-si 54907, Korea.

Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with an unknown etiology. The role of oral microbes in the development of OLP has gained researchers' interest. In this review, we summarized the findings of studies focused on the relationship between OLP and oral microbiome, which includes the composition of oral microbiota, molecules produced by oral microbiota or the host, and the oral environment of the host. Read More

View Article and Full-Text PDF

A systematic review and meta-analysis on serum and salivary levels of total antioxidant capacity and C-reactive protein in oral lichen planus patients.

Arch Oral Biol 2022 Aug 10;140:105445. Epub 2022 May 10.

Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Objective: Oral lichen planus (OLP) is an inflammatory disease that total antioxidant capacity (TAC) and C-reactive protein (CRP) play an important role in its pathogenesis. In this meta-analysis, we compared the salivary and serum levels of TAC and CRP between OLP patients and controls.

Design: A comprehensive search was performed in four databases (PubMed, Scopus, Web of Science, and Cochrane Library). Read More

View Article and Full-Text PDF

A Case Report of Dental Implants and Site Augmentation in a Patient with Erosive Lichen Planus.

Case Rep Dent 2022 16;2022:9508580. Epub 2022 May 16.

Department of Preventive Dental Sciences, Faculty of Dentistry, Najran University, Saudi Arabia.

Lichen planus (LP) is an autoimmune inflammatory disease that affects oral mucosal tissue, leading to complications in patients treated with dental implant therapy. This case report discusses the clinical management of a patient diagnosed with an erosive type of LP. After disease management, the patient was treated with dental implants in the upper and lower jaws with augmentation procedures around the implants. Read More

View Article and Full-Text PDF

Proteomic and microbiota analyses of the oral cavity during psychological stress.

PLoS One 2022 25;17(5):e0268155. Epub 2022 May 25.

Division of Oral Medicine and Pathology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan.

Psychological stress is associated with various oral diseases such as aphthous stomatitis, oral lichen planus, taste disturbances and glossodynia. However, the underlying mechanism is still unknown. The aim of this study was to determine the effect of psychological stress on salivary proteins and the oral microbiota in a rat model of chronic restraint stress. Read More

View Article and Full-Text PDF

The mechanism on Prevotella melaninogenica promoting the inflammatory progression of oral lichen planus.

Clin Exp Immunol 2022 May 23. Epub 2022 May 23.

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School of Stomatology, Tongji University, Shanghai, China.

Oral lichen planus (OLP) is a common chronic inflammatory disease occurring in the oral mucosa. Bacteria is a key driver of mucosal immune response and can induce changes in gene expression and function of epithelial keratinocytes. IL-36γ can induce the expression of antimicrobial peptides, cytokines and chemokines, and is widely involved in many chronic inflammatory diseases. Read More

View Article and Full-Text PDF

FAP-α immunofibroblasts in oral lichen planus promote CD4 T-cell infiltration via CCL5 secretion.

Exp Dermatol 2022 May 22. Epub 2022 May 22.

Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.

Oral lichen planus (OLP) is a T cell-mediated, chronic inflammatory disease. CD4 T-cell infiltration plays a crucial role in the pathogenesis of OLP. Fibroblasts are activated under pathological conditions and perform various functions. Read More

View Article and Full-Text PDF

Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: A long-term study of 34 patients.

J Oral Pathol Med 2022 May 20. Epub 2022 May 20.

Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela, Santiago, Spain.

Background: Proliferative verrucous leukoplakia is considered an uncommon oral potentially malignant disorder with a high malignant transformation rate. The objective of this paper was to define its cancer incidence and related risk factors.

Methods: A retrospective audit of 34 patients diagnosed with proliferative verrucous leukoplakia from a university-based unit, during the period from 1995 to 2019 was performed. Read More

View Article and Full-Text PDF

Efficacy of injectable platelet-rich fibrin in the treatment of symptomatic oral lichen planus.

Oral Dis 2022 May 20. Epub 2022 May 20.

Oral Diagnostic and Surgical Sciences, UWA Dental School, The University of Western Australia, Perth, WA, Australia.

Objectives: The use of autologous platelet concentrates has shown growing evidence as a promising therapy. We conducted a split-mouth study to evaluate the effectiveness of injectable platelet-rich fibrin (PRF) compared with triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).

Materials And Methods: This split-mouth randomized trial included 12 patients with symptomatic, bilateral OLP lesions. Read More

View Article and Full-Text PDF

A Retrospective Study of 23 Cases: Are Lichenoid Lesions of the Labial Mucosa Induced?

Cureus 2022 May 15;14(5):e25012. Epub 2022 May 15.

Département de Pathologie de la Muqueuse Buccale, Service de Chirurgie Maxillo-Faciale et Stomatologie, Pitié-Salpêtrière Hospital, Paris, FRA.

Background Lichen planus (LP) is a pathology that affects the skin and the mucosa. The lips are rarely involved but represent a diagnostic challenge in those cases. Oral lichenoid lesions (OLL) are defined as lesions that resemble oral lichen planus (OLP) but do not fully meet the clinical and/or histologic criteria for OLP. Read More

View Article and Full-Text PDF

Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine).

BMC Oral Health 2022 May 18;22(1):184. Epub 2022 May 18.

Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy.

Background: Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP.

Methods: 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. Read More

View Article and Full-Text PDF

Oral Lichen Planus: Associations Between Histomorphometric Characteristics and White and Red Lesions.

Head Neck Pathol 2022 May 17. Epub 2022 May 17.

Postgraduate Program in Interactive Processes of Organs and Systems of the Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil.

Histomorphometry seems to provide more rigid quantitative elements for histological analysis and to bring less subjectivity to the diagnosis of oral lichen planus lesions (OLP). This study aimed to verify the association between white and red lesions and histomorphometric characteristics of OLP lesions. This retrospective cross-sectional study assessed 48 hematoxylin- and eosin-stained histological sections from incisional biopsies obtained from OLP cases. Read More

View Article and Full-Text PDF