4,849 results match your criteria Oral Lichen Planus

Acquired White Oral Lesions with Specific Patterns: Oral Lichen Planus and Lupus Erythematosus.

Dermatol Pract Concept 2021 May 20;11(3):e2021074. Epub 2021 May 20.

Dermatology Clinic, Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Background: Diagnosis of oral white lesions might be challenging. These lesions represent a wide spectrum of diseases with different etiology and prognosis. Oral white lesions can be categorized into two major groups, congenital and acquired, according to their development, and in four subgroups: lesions which can be scraped off or not and lesions with special pattern or not. Read More

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Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients.

BMC Oral Health 2021 Jun 10;21(1):298. Epub 2021 Jun 10.

Department of Oral and Maxillofacial Surgery, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear.

Methods: We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. Read More

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[Experimental study on the structure and immune cell phenotypes of the lymphoid tissues in oral lichenoid lesions].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):113-119

College of Stomatology, Weifang Medical University. Weifang 261021, Shandong Province, China.

Purpose: To evaluate the existence of tertiary lymphoid structures(TLS) in oral lichenoid lesions and its compositional characteristics of immune cells.

Methods: Tissue samples of normal oral mucosa, oral lichen planus (OLP) and oral lichenoid tissue reaction(OLTR) were collected, thirty cases in each group. Hematoxylin-eosin(H-E) staining was performed to identify the TLS-like structures, and immunohistochemistry (IHC) staining was applied to assess the structure and amount of infiltrating CD3+ T cells, CD19+, CD20+ B cells, CD21+ follicular dendritic cells (FDC), Bcl-6+ germinal centers, CD34+ PNAd+ venules and CD34+ Gp36+ micro lymphatic vessels in TLS of OLL. Read More

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Lichen Planus Due to Hirudotherapy

Turkiye Parazitol Derg 2021 06;45(2):149-152

Necmettin Erbakan University Meram Medical School, Department of Pathology, Konya, Turkey

Lichen planus is a traumatic (koebner positive), chronic, inflammatory and autoimmune disease affecting the oral and genital mucosa, scalp and nails. The Food and Drug Administration approved the use of medical leeches for therapeutic purposes (hirudotherapy) in 2004 to ensure flap nutrition in plastic surgery. A 34-year-old male patient was admitted to our dermatology outpatient clinic with a swollen, itchy and purple-coloured rash on legs and back for a month, and white and reticulated plaques in the mouth. Read More

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An atypical presentation of plasma cell gingivitis with generalized skin lesions.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S54-S57. Epub 2021 Mar 19.

Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

This article aims to present a report of an atypical clinical presentation of a plasma cell gingivitis (PCG) case with unusual skin lesions. PCG is a rare benign inflammatory condition which can be classified into Type 4 hypersensitivity reaction. It occurs due to reaction to unknown antigen, often flavoring agents or spices found in chewing gums, toothpastes and lozenges. Read More

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Impact of Oral Lichen Planus on Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis.

Clin Pract 2021 May 7;11(2):272-286. Epub 2021 May 7.

People's College of Dental Sciences & Research Centre, Bhopal 462037, India.

Oral health-related quality of life (OR-QoL) measurement in patients with oral lichen planus (OLP) can provide valuable information for the optimal management of their clinical conditions. The main objective of the present study was to assess the OR-QoL of patients with OLP as measured by the short-form Oral Health Impact profile-14 (OHIP-14) questionnaire. PubMed/MEDLINE, ISI/Web of Science, clinical trial registry, Embase, Scopus, and grey literature (via Google Scholar and Scilit) were searched. Read More

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Lichenoid dysplasia is not a distinct pathological entity.

Oral Oncol 2021 May 29;119:105362. Epub 2021 May 29.

Australian eHealth Research Centre, The Commonwealth Scientific & Industrial Research Organisation, Floreat, WA, Australia. Electronic address:

Objectives: Oral Lichenoid Dysplasia (OLD) is a controversial histological term applied to lesions that display features of oral lichen planus (OLP) and oral epithelial dysplasia (OED). In this study we investigated the molecular profiles of OLD, OLP and OED to determine whether OLD exists as a distinct pathological entity.

Materials And Methods: Samples from patients presenting with lesions diagnosed histologically as OLP, OLD or OED underwent RNA sequencing followed by differential gene expression, functional enrichment and network analysis, sparse partial least squares discriminant analysis, and immune cell phenotypic estimation. Read More

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Impaired Taste Perception in Lichen Planus Patients with Tongue Involvement.

Oral Health Prev Dent 2021 Jan;19(1):287-294

Purpose: To analyse the taste function in a pool of untreated patients with oral lichen planus (OLP) with tongue lesions (n = 35) and without tongue lesions (n = 36) and to compare it to healthy subjects (n = 36).

Materials And Methods: Firstly, the subjective overall taste ability and impairment of the sensations of 'sweet', 'sour', 'salty' and 'bitter' were recorded in all three groups. Secondly, taste function was tested in all included subjects using the standardised 'Taste Strips' test. Read More

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January 2021

Limited Evidence Suggests About One in Five Potentially Premalignant Oral Lesions Is Related to Human Papillomavirus.

Linda L Cheng

J Evid Based Dent Pract 2021 Mar 2;21(1):101531. Epub 2021 Feb 2.

Article Title And Bibliographic Information: Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis. de la Cour CD, Sperling CD, Belmonte F, Syrjänen S, Kjaer SK. Oral Dis. Read More

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Diabetes mellitus and oral lichen planus: A systematic review and meta-analysis.

Oral Dis 2021 May 29. Epub 2021 May 29.

Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.

Objective: To undertake a meta-analysis of the association of Oral Lichen Planus (OLP) with diabetes, two diseases with an important impact on public health and the economy, but the evidence of which about their association is inconsistent.

Methods: Relevant studies were localized by searching MEDLINE, EMBASE, Conference Proceedings, and other databases from inception to October 2020, without restrictions. The reference lists of included studies and of related reviews were also inspected. Read More

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Expression profile of circular RNAs in oral lichen planus.

Ann Palliat Med 2021 May 14;10(5):5205-5217. Epub 2021 May 14.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Background: This study sought to identify the circular RNAs (circRNAs) differentially expressed in oral lichen planus (OLP) to investigate the possible role of circRNAs in this disease's pathogenesis.

Methods: Six OLP and six normal oral mucosal tissues were used for circRNA detection and sequencing. 10 selected circRNAs were verified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Read More

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Estimation of a neutrophil activation marker in lichen planus patients.

J Cosmet Dermatol 2021 May 27. Epub 2021 May 27.

Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues, which its aetiology and pathogenesis are unclear. Cytokines have a significant role in the beginning, the maintenance of inflammatory and intercellular crosstalk.

Aim: We assessed serum levels of neutrophil activation marker (calprotectin) in patients cutaneous lichen planus with different subtypes and made a comparison with healthy individuals. Read More

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Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis.

Mucosal Immunol 2021 May 26. Epub 2021 May 26.

Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, PR China.

Oral mucosal disease (OMD), which is also called soft tissue oral disease, is described as a series of disorders or conditions affecting the mucosa and soft tissue in the oral cavity. Its etiology is unclear, but emerging evidence has implicated the influence of the composition of the oral mucosa and saliva-resident microbiota. In turn, this dysbiosis effects the immune response balance and epithelial barrier function, followed by the occurrence and progression of OMD. Read More

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Markers associated with malignant transformation of oral lichen planus: A review article.

Arch Oral Biol 2021 Jul 15;127:105158. Epub 2021 May 15.

Student Research Committee, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Oral lichen planus (OLP) is one of the autoimmune diseases associated with chronic inflammation that involves several complications including the potential for malignant transformation into oral squamous cell carcinoma. Pathogenesis of OLP are yet to be fully comprehended however, it has been demonstrated that the epithelial cells in OLP lesions are affected by cytotoxic T lymphocytes leading to immunological reactions. Various factors are reported to act as diagnostic markers for predicting and monitoring the cancerous progression. Read More

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What Do the Lips Say in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation? A Case Series.

Dermatol Ther (Heidelb) 2021 May 20. Epub 2021 May 20.

Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology (MSCNRIO), Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland.

Introduction: Chronic graft-versus-host disease (cGvHD) affects around half of allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients, with frequent involvement of the oral mucosa and lip vermillion, that clinically may resemble other autoimmune and inflammatory conditions. Our objectives were to define the dermoscopic patterns of lip vermilion in patients suffering from cGvHD and to compare the presentation with previously published dermoscopic presentations of other disease entities presenting on the lip vermillion.

Methods: A group of 16 patients diagnosed with cGvHD was assessed clinically and dermoscopically. Read More

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Immunohistochemical Characterization of Bcl-2 in Oral Potentially Malignant Disorders.

Appl Immunohistochem Mol Morphol 2021 May 17. Epub 2021 May 17.

Oral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS) Pathological Anatomy Service, University Hospital Complex of Santiago (CHUS), Santiago de Compostela Oral and Maxillofacial Pathology and Oral Medicine Unit, Department of Stomatology II, University of the Basque Country, Leioa, Spain Special Care Dentistry Centre (CAPE) and Oral Pathology, Department of Stomatology, University of São Paulo School of Dentistry (USP), São Paulo, Brazil.

Bcl-2 is a group of apoptotic proteins that play a key role in cellular homeostasis. Overexpression of Bcl-2 has been associated with the poor prognosis of oral squamous cell carcinoma (OSCC). The aim of this study is to analyze the immunohistochemical expression of Bcl-2 in healthy oral mucosa, different oral potentially malignant disorders and OSCC, and to determine its diagnostic value. Read More

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Clinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life.

BMC Oral Health 2021 05 15;21(1):262. Epub 2021 May 15.

Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149, Muenster, Germany.

Background: The aim of this study was to investigate the influence of clinical characteristics and dental restorative materials on oral health-related quality of life in patients with oral lichen planus. In particular, the influences of amalgam and metals were investigated.

Methods: A total of 112 patients with clinical and histological features of oral lichen planus from the Department of Cranio-Maxillofacial Surgery at the University Hospital of Münster participated in this prospective study. Read More

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Narrow-band imaging features of oral lichenoid conditions: A multicentre retrospective study.

Oral Dis 2021 May 13. Epub 2021 May 13.

Australian Centre for Oral Oncology Research & Education, Pert, WA, Australia.

Objective: Narrow-band imaging (NBI), which highlights epithelial intrapapillary capillary loops (IPCLs) classified into five patterns (0 toIV) with increasing correlation to malignancy, has demonstrated effectiveness for detection of oral squamous cell carcinoma (OSCC). Lack of standardised procedures limits its use for routine inspection of oral lichenoid lesions including oral lichen planus (OLP), oral lichenoid lesion (OLL) and oral lichenoid reaction (OLR). The aim of this study was to analyse IPCL patterns of such lesions, assessing correlations with histopathological outcomes. Read More

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Georgian Med News 2021 Mar(312):71-74

Tbilisi State Medical University, department of dermatology and venerology, Georgia.

The clinical picture and course of lichen planus (LP) on the mucous membrane of the oral cavity have significant differences from its manifestations on the skin. In particular, greater resistance to treatment, which is due to the structural features of the mucous membrane, as well as the specificity of biological and physicochemical processes in the oral cavity. There are 6 clinical forms of LP of the red border of the lips and oral mucosa - typical, hyperkeratotic, exudative-hyperemic, erosive - ulcerative, bullous and atypical. Read More

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Correlation of Mast Cell and Angiogenesis in Oral Lichen Planus, Dysplasia (Leukoplakia), and Oral Squamous Cell Carcinoma.

Rambam Maimonides Med J 2021 Apr 29;12(2). Epub 2021 Apr 29.

Oral and Maxillofacial Surgery, Asan Memorial Dental College and Hospital, Keerapakkam Village, Asan Nagar, Chengalpattu, India.

Objective: The aim of this study was to compare and correlate mast cell density (MCD) and microvessel density (MVD) between normal oral mucosa, oral lichen planus, various grades of dysplasia, and oral squamous cell carcinoma (OSCC).

Materials And Methods: The study comprised a total of 75 samples, of which 65 were archival tissue blocks of histopathologically confirmed cases, which included 10 cases of oral lichen planus, 25 cases of dysplasia (mild [n=10], moderate [n=10], and severe [n=5]), and 30 cases of OSCC (well differentiated [n=10], moderately differentiated [n=10], and poorly differentiated [n=10]), and 10 samples of normal oral mucosa. All the sections were immunohistochemically stained with anti-CD34 and counterstained with toluidine blue stain. Read More

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Inter-Observer and Intra-Observer Variations in the Assessment of Epithelial Dysplasia in Oral Lichenoid Diseases.

Dermatopathology (Basel) 2021 Apr 1;8(2):84-88. Epub 2021 Apr 1.

Department of Dermatology, Inselspital Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland.

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) can both present with histological dysplasia. Despite the presence of WHO-defined criteria for the evaluation of epithelial dysplasia, its assessment is frequently subjective (inter-observer variability). The lack of reproducibility in the evaluation of dysplasia is even more complex in the presence of a lichenoid inflammation. Read More

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Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review.

Ethiop J Health Sci 2020 Jul;30(4):615-622

Dentist, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Oral lichen planus (OLP) is known to be a chronic inflammatory disease associated with various other systemic disorders. Studies have shown that vitamin D deficiency can be involved in the pathogenesis of lichen planus. The aim of this study was to investigate the role of vitamin D and vitamin D receptor in OLP. Read More

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Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.

Cancer Biomark 2021 Apr 12. Epub 2021 Apr 12.

Background: Oral squamous cell carcinoma (OSCC) usually originates from oral potentially malignant disorders (OPMD), such as oral leukoplakia (OLK) and oral lichen planus (OLP). Identifying biomarkers for the early diagnosis and evaluation of malignant transformation in OPMD could improve the survival rate of OSCC patients.

Objective: The present study aimed to screen for potential salivary biomarkers for evaluating the malignant transformation of OPMD. Read More

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Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition.

BMC Microbiol 2021 Apr 20;21(1):122. Epub 2021 Apr 20.

Key Laboratory for Experimental Teratology of Ministry of Education and Department of Microbiology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.

Background: Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Read More

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Tacrolimus inhibits oral carcinogenesis through cell cycle control.

Biomed Pharmacother 2021 Jul 16;139:111545. Epub 2021 Apr 16.

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, PR, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, PR, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR, China. Electronic address:

Tacrolimus (TAC, FK506) is a major calcineurin inhibitor and has been commonly used in treatments of patients with organ transplants and immune diseases. Moreover, tacrolimus is recommended by the treatment guidelines for oral potentially malignant disorders (OPMDs) such as oral lichen planus (OLP). However, whether tacrolimus increases the risk of cancer remains controversial. Read More

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From Simple Mouth Cavities to Complex Oral Mucosal Disorders-Curcuminoids as a Promising Therapeutic Approach.

ACS Pharmacol Transl Sci 2021 Apr 17;4(2):647-665. Epub 2021 Mar 17.

Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India.

Oral diseases are among the most common encountered health issues worldwide, which are usually associated with anomalies of the oral cavity, jaws, and salivary glands. Despite the availability of numerous treatment modalities for oral disorders, a limited clinical response has been observed because of the inefficacy of the drugs and countless adverse side effects. Therefore, the development of safe, efficacious, and wide-spectrum therapeutics is imperative in the battle against oral diseases. Read More

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Patch test of dental materials in Oral Lichen Planus with considering the role of saliva.

Sci Rep 2021 Apr 15;11(1):8264. Epub 2021 Apr 15.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Lichen planus is the most common skin disease that affects the oral mucosa. Oral Lichen Planus is a T-cell-mediated autoimmune disorder. In the current study, for the first time, an oral cavity condition in skin patch tests with adding saliva is simulated. Read More

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