4,278 results match your criteria Oral Lichen Planus


Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus.

Genet Mol Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgical, Medical and Health Sciences, University of Trieste, Trieste, Italy.

Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of the innate immune response and an acute-phase protein able to activate the complement cascade, was investigated to assess a possible association with OLP susceptibility in Italian patients. Two variations at the promoter region (called H/L and X/Y) and three at the first exon (at codon 52, 54, and 57) of the MBL2 gene were analyzed in 69 OLP patients and 244 healthy controls from northeastern Italy. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2018-0015DOI Listing
February 2019

Artificial nail wearing: unexpected elicitor of allergic contact dermatitis, oral lichen planus and risky arthroplasty.

Contact Dermatitis 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology and Allergology, Ludwig-Maximilian University Munich, Munich, Germany.

Despite the increasing use of (meth)acrylates both in dentistry and beauty treatments allergic reactions may often not be identified as such. We report a patient who developed dermatitis upon use of acrylate finger nails and exposure to paint dust followed by oral pain and erosive lichen planus due to acrylate based dental fillings. Subsequently the patient was seeking advice as dental implants and a cemented arthroplasty were planned. Read More

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http://dx.doi.org/10.1111/cod.13250DOI Listing
February 2019

Koebnerization of Eruptive Keratoacanthoma Into Lesions of Classic Lichen Planus Treated With Oral Acitretin.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

DermSurgery Associates, Houston, Texas Dermatology Associates of Sugar Land, Sugar Land, Texas DermSurgery Associates, Houston, Texas Department of Medicine Houston Methodist Hospital, Houston, Texas Department of Dermatology, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1097/DSS.0000000000001793DOI Listing
February 2019

Comorbidities in Lichen Planus: A Case-control Study in Indian Patients.

Indian Dermatol Online J 2019 Jan-Feb;10(1):34-37

Department of Dermatology, Maharajah's Institute of Medical Sciences, Nellimarla, Vizianagaram, Andhra Pradesh, India.

Background: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection.

Materials And Methods: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_48_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362740PMC
February 2019

Evaluation of polymorphism of protein codon 72 in oral lichen planus by PCR technique.

J Dent Res Dent Clin Dent Prospects 2018 19;12(4):245-251. Epub 2018 Dec 19.

Department of Genetics, Research and Clinical Center for Infertility, Shahid Sadoughi Medical Sciences University, Yazd, Iran.

Our research was aimed to study protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Seventy paraffin-embedded tissue samples (30 OLP, 20 OSCC and 20 IFH) were studied. DNA was purified and amplified using allele-specific polymerase chain reaction to detect polymorphism. Read More

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http://dx.doi.org/10.15171/joddd.2018.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368942PMC
December 2018

In vivo reflectance confocal microscopy of oral lichen planus.

Int J Dermatol 2019 Feb 17. Epub 2019 Feb 17.

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: In vivo reflectance confocal microscopy (RCM) is an imaging technique that can virtually biopsy vital tissues, noninvasively and in real time. It results in horizontal virtual slices at a microscopic resolution that correlates well with conventional histopathology. Despite the widespread use of RCM in dermatology, it is still rarely applied to the study of oral pathologies. Read More

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http://dx.doi.org/10.1111/ijd.14410DOI Listing
February 2019

[DNA cytometry of exfoliated cells in the diagnosis of oral potential malignant disorders].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):16-20

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the diagnostic efficiency of oral mucosa disease, especially oral squamous cell carcinoma (OSCC) and oral potential malignant disorders (OPMDs) by DNA cytometry compared with histopathological diagnosis, so as to find a convenient, simple and low-invasive method for screening and follow-up.

Methods: 203 subjects with OSCC, OPMDs and other oral mucosa disease without dysplasia according to the inclusion criteria and exclusion criteria were recruited from Peking University School and Hospital of Stomatology. The mean age was (52. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.004DOI Listing
February 2019

Aberrant IGF1-PI3K/AKT/MTOR signaling pathway regulates the local immunity of oral lichen planus.

Immunobiology 2019 Feb 10. Epub 2019 Feb 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, PR China. Electronic address:

Objectives: Oral lichen planus (OLP) is a T cell-mediated immune-related chronic disease, featured by accumulation of T cells and apoptosis of keratinocytes. Insulin-like growth factors 1 (IGF1) signaling, in combination with its downstream PI3K/AKT/MTOR cascade, plays pivotal roles in the regulation of inflammation and immune response. Meanwhile, TRB3 acts as a connective protein in the pathway. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.004DOI Listing
February 2019

Oral lichen planus and lichen planopilaris complicated with thymoma.

J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14812DOI Listing
February 2019
1 Read

Expression of Cluster of Differentiation 1a-Positive Langerhans Cells in Oral Lichen Planus.

Indian J Dermatol 2019 Jan-Feb;64(1):41-46

Department of Oral Pathology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India.

Background/purpose: Lichen planus is a T-cell-mediated mucocutaneous disorder characterized histopathologically by a band of chronic inflammatory cells in the subepithelial zone and degeneration of basal layer. The present study was aimed to evaluate the distribution and quantitative assessment of cluster of differentiation 1a (CD1a)-positive Langerhans cells (LCs) in oral lichen planus (OLP), thus to determine the role of LCs pertaining to the changes occurring in OLP.

Materials And Methods: Five cases of normal oral mucosa and 20 cases of OLP were immunostained with CD1a antibody; the positive cells were counted manually in the photomicrographs and statistically analyzed using -test, Mann-Whitney test, and Wilcoxon signed-rank test. Read More

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http://dx.doi.org/10.4103/ijd.IJD_350_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340233PMC
February 2019

Foreign body gingivitis: An uncommon iatrogenic simulant of oral lichenoid mucositis.

JAAD Case Rep 2019 Feb 31;5(2):173-175. Epub 2019 Jan 31.

Department of Dermatology, University of California, San Francisco, California.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357549PMC
February 2019

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus.

Oral Dis 2019 Feb 9. Epub 2019 Feb 9.

Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. IκB kinase α (IKKα)-regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response. Read More

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http://doi.wiley.com/10.1111/odi.13054
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http://dx.doi.org/10.1111/odi.13054DOI Listing
February 2019
3 Reads

Serum-based metabolomics characterization of patients with reticular oral lichen planus.

Arch Oral Biol 2019 Jan 30;99:183-189. Epub 2019 Jan 30.

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China. Electronic address:

Objective: Oral lichen planus (OLP) is a chronic inflammatory mucosal lesion and systemic disease. In OLP, reticular type is the most common presentation of the disease. However, little is known about it. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.01.019DOI Listing
January 2019
1 Read

[Gingival squamous cell carcinoma diagnosed on the occasion of osteonecrosis of the jaw in a patient with chronic GVHD].

Rinsho Ketsueki 2019 ;60(1):22-27

Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University.

A 44-year-old male was diagnosed with acute myeloid leukemia with a complex karyotype. He underwent bone marrow transplantation using an HLA 6/6 antigen-matched sibling donor, but developed chronic graft-versus-host disease (cGVHD) with skin erythema and oral and esophageal lichen planus changes. Treatment with a combination of prednisolone and cyclosporine was initiated on day 646 after transplantation, but oral symptoms persisted. Read More

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http://dx.doi.org/10.11406/rinketsu.60.22DOI Listing
January 2019
2 Reads

Association of nitric oxide with oral lichen planus.

J Oral Pathol Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: The small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP.

Methods: The focused question being addressed was "Is there an association between nitric oxide and OLP?" PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Read More

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http://dx.doi.org/10.1111/jop.12837DOI Listing
February 2019

The Gingival Oral Lichen Planus: A Periodontal-Oral Medicine Approach.

Case Rep Dent 2019 6;2019:4659134. Epub 2019 Jan 6.

NK Perio & Implants, Perth 6172 Western Australia, Australia.

We present a case of a 77-year-old female who suffered from oral lichen planus (OLP) involving her gingiva and bilateral buccal mucosa for over 6 months. We showed that oral hygiene measures and conventional periodontal treatment and strict maintenance were sufficient to control the gingival involvement of OLP. The mechanism of OLP is complex and not yet fully understood. Read More

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http://dx.doi.org/10.1155/2019/4659134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339732PMC
January 2019

Mucous membrane pemphigoid of the oral lichen type: a retrospective analysis of 16 cases.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Inselspital - Bern University Hospital, CH-3010, Bern, Switzerland.

Mucous membrane pemphigoid (MMP) and oral lichen planus (OLP) may be difficult to distinguish. We describe the characteristics of a retrospective series of patients with MMP with isolated oral involvement who presented clinical features indistinguishable from OLP. Proper classification of these MMP cases critically depended on the performance of direct immunofluorescence (DIF) microscopy studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15473
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http://dx.doi.org/10.1111/jdv.15473DOI Listing
February 2019
4 Reads

Artemisinin and its derivatives: a potential therapeutic approach for oral lichen planus.

Inflamm Res 2019 Feb 1. Epub 2019 Feb 1.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, People's Republic of China.

Background: Oral lichen planus (OLP) is a common T-cell-mediated oral mucosal disease, whose pathogenesis mainly includes antigen-specific and non-specific mechanisms. As a refractory chronic inflammatory disease, there is still no curable management for OLP till now.

Findings: Artemisinins are a family of compounds that are widely used as frontline treatment for malaria worldwide. Read More

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http://link.springer.com/10.1007/s00011-019-01216-0
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http://dx.doi.org/10.1007/s00011-019-01216-0DOI Listing
February 2019
7 Reads

Impressive oral lichen planus progression to invasive squamous cell carcinoma in a three months lapse.

Oral Oncol 2019 Jan 28. Epub 2019 Jan 28.

Dermatology Clinic - Department of Medical Sciences and Public Health, University of Cagliari, Via Ospedale 54, 09124 Cagliari, Italy.

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.029DOI Listing
January 2019

The reciprocal association between diabetes mellitus and erosive oral lichen planus.

Oral Dis 2019 Jan 30. Epub 2019 Jan 30.

State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P.R. China.

We read with interest the article by Otero Rey E. M. and colleagues that was recently published in Oral Diseases (Otero Rey E. Read More

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http://dx.doi.org/10.1111/odi.13050DOI Listing
January 2019

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review.

Head Neck Pathol 2019 Jan 31. Epub 2019 Jan 31.

Department of Diagnostic and Biomedical Sciences, University of Texas at Houston Health Science Center School of Dentistry, Houston, TX, USA.

Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Read More

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http://dx.doi.org/10.1007/s12105-018-0981-8DOI Listing
January 2019
1 Read

[Research progress of dental implant in patients with oral lichen planus].

Authors:
L Fu L A C Y Li Y M Zhou

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):135-137

Department of Dental Implantology, School of Stomatology, Jilin University, Changchun 130021, China.

In recent years, the range of indications for dental implants has undergone many modifications and has been widened. In the past, oral lichen planus was regarded as contraindication for the placement of implants. According to recent literature, some patients with oral lichen planus have been selected for dental implantology, indicating comparable implant survival rate to patients without oral lichen planus. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.02.011DOI Listing
February 2019

Clinical photography: Attitudes among dental students in two dental institutions.

Eur J Dent Educ 2019 Jan 25. Epub 2019 Jan 25.

Department of Community Dentistry, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

Introduction: Clinical photography is an important tool in teaching, clinical practice and academia especially for mucosal pathologies. Our aim was to examine differences in attitude towards clinical photography for mucosal pathologies among students.

Methods: Questionnaires about clinical photography were completed by students in dental teaching hospitals in Birmingham (UK) and in Israel (ISR). Read More

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http://dx.doi.org/10.1111/eje.12424DOI Listing
January 2019
1 Read
1.448 Impact Factor

Seven-year itch: a perplexing case of lichen planus-lupus erythematosus overlap syndrome.

Dermatol Online J 2018 Sep 15;24(9). Epub 2018 Sep 15.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, New York.

Lichen planus-lupus erythematosus overlap syndrome is a rare disorder characterized by clinical and histopathological features of both lichen planus (LP) and lupus erythematosus (LE). Cutaneous lesions commonly affect the distal arms, legs, face, and trunk and these plaques are often large, scaly, painful, and atrophic, often exhibiting hypopigmentation or a red to blue-violet color. We report a case of LP-LE overlap syndrome diagnosed in a man previously believed to have atypical lichen planus who presented with an exacerbation of exuberant pruritic erythematous scaly plaques. Read More

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September 2018
1 Read

Association of OLP and thyroid disorder: Case report and review of literature.

J Stomatol Oral Maxillofac Surg 2019 Jan 21. Epub 2019 Jan 21.

Department of Oral Medicine, Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, India.

Oral lichen planus is a chronic T cell mediated inflammatory condition with multifactorial etiology. Being autoimmune mediated condition, it has been associated with other autoimmune disorders. This case report discusses the possible presentation of oral lichen planus in hypothyroid patients as a marker of severity of the thyroid deficient status and the possible pathogenetic link between both the conditions. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.01.008DOI Listing
January 2019

Assessment of Interleukin-18 gene polymorphism and serum levels in oral lichen planus in an Indian population.

J Oral Pathol Med 2019 Jan 22. Epub 2019 Jan 22.

Pediatrics Research and Genetics Laboratory, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.

Background: Oral lichen planus (OLP) is a chronic, inflammatory disease with uncertain etiology. The aim of this study was to assess Interleukin-18 (IL-18) gene polymorphism and serum levels in OLP cases of Indian origin and to compare them with a control population of similar background.

Methods: The assessment of single-nucleotide polymorphisms (SNPs) of IL-18 gene at promoter regions -137(G/C) and -607(C/A) was done in 70 OLP cases and 70 healthy controls using sequence-specific primer-polymerase chain reaction (SSP-PCR). Read More

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http://dx.doi.org/10.1111/jop.12830DOI Listing
January 2019

miR‑122 and miR‑199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway.

Int J Mol Med 2019 Mar 21;43(3):1373-1381. Epub 2019 Jan 21.

Department of Geriatrics, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.

The aim of the present study was to characterize the roles of two microRNAs (miRNAs), miR‑122 and miR‑199, in oral lichen planus (OLP). miRNA microarray analysis was performed to detect potential miRNAs involved in OLP, while in‑silicon analysis, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), western blot and immunohistochemistry (IHC) analyses were utilized to explore the molecular mechanisms underlying the roles of miR‑199 and miR‑122 in OLP. The results from the microarray and RT‑qPCR analyses demonstrated that the expression levels of miR‑122 and miR‑199 were significantly decreased in the peripheral blood mononuclear cells (PBMCs) collected from the OLP group compared with the control group. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365087PMC
March 2019
1 Read

Isolated lichen planus of lip: Diagnosis and treatment monitoring using dermoscopy.

Clin Case Rep 2019 Jan 22;7(1):146-148. Epub 2018 Nov 22.

Department of Dermatology College of Medical Sciences Bharatpur Nepal.

Lichen planus (LP) of lip has chances of malignant transformation as it may be exposed to external trauma, smoking, and ultraviolet light. This case highlights the use of dermoscope as a quick noninvasive tool for the diagnosis of LP of lip and monitoring the response to treatment. Read More

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http://dx.doi.org/10.1002/ccr3.1933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333123PMC
January 2019
1 Read

Role of miR-155 in immune regulation and its relevance in oral lichen planus.

Exp Ther Med 2019 Jan 27;17(1):575-586. Epub 2018 Nov 27.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine of West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Oral lichen planus (OLP) is a chronic mucosal inflammatory disease. The World Health Organization has described it as a potentially malignant condition. The pathogenesis of OLP remains to be fully elucidated, but extensive evidence suggests that immunologic and inflammatory factors have important roles. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7019
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http://dx.doi.org/10.3892/etm.2018.7019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307429PMC
January 2019
3 Reads

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort.

PLoS One 2019 16;14(1):e0210070. Epub 2019 Jan 16.

Cancer Epidemiology Research Program, IDIBELL, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.

Background: Human papillomavirus (HPV) is the cause of a fraction of head and neck squamous cell carcinoma. Although this relation is well-known, it is still not clear the role of HPV in premalignant oral lesions such as oral lichen planus (OLP) and dysplasia. We aimed to evaluate the HPV-DNA prevalence and type distribution in a set of oral biopsies obtained from patients diagnosed with OLP and dysplasia, as well as the role of HPV in these lesions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335078PMC
January 2019
5 Reads

Evaluation of serum and salivary interferon-γ levels in patients with oral lichen planus: a systematic review and meta-analysis of case-control studies.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Mar 24;127(3):210-217. Epub 2018 Nov 24.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Objective: Cytokines have regulatory and leading roles in the immunopathogenesis of oral lichen planus (OLP). Here, we present the findings of a meta-analysis that evaluated serum and salivary interferon-γ (IFN-γ) levels in patients with OLP compared with those in controls and the correlation of this cytokine with the progression of OLP.

Study Design: Four databases-PubMed, Web of Science, Scopus, and Cochrane Library-were searched, from their start dates to November 2017, for reports in all languages on the effect of OLP on salivary and serum IFN-γ. Read More

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http://dx.doi.org/10.1016/j.oooo.2018.11.006DOI Listing

Downregulated miR-27b promotes keratinocyte proliferation by targeting PLK2 in oral lichen planus.

J Oral Pathol Med 2019 Jan 14. Epub 2019 Jan 14.

Department of Oral Medicine, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: MicroRNA-27b (miR-27b) was recently found to be significantly downregulated in oral lichen planus (OLP). However, evidence of the function of miR-27b in OLP remains limited.

Methods: Initially, miR-27b expression in OLP was verified using the quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1111/jop.12826DOI Listing
January 2019
1 Read

A systematic review and meta-analysis study of salivary and serum interleukin-8 levels in oral lichen planus.

Postepy Dermatol Alergol 2018 Dec 13;35(6):599-604. Epub 2018 Nov 13.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: Interleukin-8 (IL-8) is an important mediator of the host response to injury and inflammation that the clinical severity of oral lichen planus (OLP) is associated with elevated serum IL-8 levels.

Aim: To evaluate serum and salivary IL-8 levels of the OLP patients compared with the healthy controls and measurement of IL-8 level in which sample is more valuable.

Material And Methods: Five databases including PubMed/Medline, Web of Science, Science Direct, Cochrane Library and Scopus were searched for the evaluation of serum and salivary IL-8 levels of the OLP patients compared with the healthy controls in the English abstract. Read More

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http://dx.doi.org/10.5114/ada.2018.77611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320489PMC
December 2018

Curcumin, a turmeric extract, for oral lichen planus: A systematic review.

Oral Dis 2019 Jan 7. Epub 2019 Jan 7.

University of Connecticut School Dental Medicine, Farmington, Connecticut.

Objective: Conduct a PROSPERO registered (CRD42018105227) systematic review of the efficacy of curcumin in the treatment of oral lichen planus (OLP).

Data Sources: Medline from the earliest possible date to the present (December 18, 2018) using the terms "turmeric" OR "curcumin" OR "curcuma" AND "oral lichen planus".

Study Selection And Data Extraction: Studies assessing patient outcomes in OLP. Read More

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http://doi.wiley.com/10.1111/odi.13034
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http://dx.doi.org/10.1111/odi.13034DOI Listing
January 2019
15 Reads

'Nasal flossing': A case report of nasopharyngeal stenosis due to severe erosive lichen planus and a novel therapeutic intervention.

Int J Surg Case Rep 2019 13;54:99-102. Epub 2018 Nov 13.

NHS GGC, Professor of Maxillofacial Surgery, University of Bradford, United Kingdom.

Introduction: We describe a case of severe erosive oral lichen planus that led to nasopharyngeal stenosis. This is a rare clinical presentation that was ultimately, successfully treated by surgery combined with post-operative 'nasal flossing': a novel therapeutic intervention.

Presentation Of Case: A 76-year-old male suffering from a rare case of severe oral lichen planus that was resistant to conservative measures is described. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317303PMC
November 2018

[Oral lichen planus. Case report and literature review].

Rev Alerg Mex 2018 Oct-Dec;65(4):424-430

Universidad Juárez del Estado de Durango, Facultad de Odontología, División de Estudios de Posgrado e Investigación, Durango, México.

Background: Oral lichen planus is a chronic inflammatory skin disease of autoimmune nature, with infiltration of T lymphocytes that destroy the basal stratum, which causes white striae, erosions, ulcers and breaks in epithelial continuity.

Case Report: 54-year-old woman with multiple reticular and erosive lesions in the region of the buccal mucosa and lateral borders of the tongue, as well as desquamative gingivitis. Treatment with mometasone was started thrice daily for 20 days and intermittently with miconazole gel to prevent iatrogenic mycosis by the corticosteroid. Read More

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http://dx.doi.org/10.29262/ram.v65i4.342DOI Listing
January 2019

Psychological problems and quality of life of patients with oral mucosal diseases: a preliminary study in Chinese population.

BMC Oral Health 2018 Dec 27;18(1):226. Epub 2018 Dec 27.

Department of General Dentistry, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou City, China.

Background: Psychological problems might play important roles in oral mucosal diseases such as recurrent aphthous ulcers (RAU), oral lichen planus (OLP), burning mouth syndrome (BMS), but the relevance to patients' quality of life remained controversial. The aim of this study was to investigate the psychological problems and oral health-related quality of life in patients with RAU, OLP, and BMS in China, to assess the relationship between psychological problems and quality of life.

Method: Thirty-nine RAU patients, 45 OLP patients, 15 BMS patients and 45 healthy controls were enrolled in the study. Read More

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http://dx.doi.org/10.1186/s12903-018-0696-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307175PMC
December 2018
1 Read

Immunological methods for the diagnosis of oral mucosal diseases.

Br J Dermatol 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine of West China Hospital of Stomatology, Sichuan University, Chengdu, China.

The immunological methods have been widely used in autoimmune blistering diseases (AIBDs) of the oral mucosa, which can also be adopted as auxiliary diagnostic tools in oral lichen planus (OLP) and discoid lupus erythematosus (DLE). AIBDs, characterized by autoantibodies against structural proteins of keratinocytes or the basement membrane zone, clinically presents as blisters and erosions of the oral mucosa. When atypical lesions occur, OLP or DLE may be confused with AIBDs. Read More

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http://dx.doi.org/10.1111/bjd.17589DOI Listing
December 2018

Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3635-3641. Epub 2018 Dec 25.

Department of Oral Medicine and Radiology, M. M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India. Email:

Objectives: The present observational study was conducted with an aim to evaluate the efficacy of diode laser in management of homogenous oral leukoplakia (OL) and reticular oral lichen planus (OLP), so that these potentially malignant disorders can be limited and further malignant transformation can be prevented. Further the assessment of associated postoperative complications after laser therapy was also carried out. Study Design: Present study was carried out using diode laser 810nm on 60 subjects, of whom 30 subjects were of homogenous OL and 30 subjects were of reticular OLP aged between 20 – 60 years, the diagnosis of which was histopathologically confirmed. Read More

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http://journal.waocp.org/article_80075.html
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http://dx.doi.org/10.31557/APJCP.2018.19.12.3635DOI Listing
December 2018
2 Reads
1.500 Impact Factor

Malignant transformation rates in Oral Lichen Planus.

Authors:
Derek Richards

Evid Based Dent 2018 Dec;19(4):122

Centre for Evidence-Based Dentistry, Dundee Dental School, University of Dundee, Dundee, Scotland.

Data sourcesPubMed, Scopus and Web of Science databases.Study selectionCohort, case-control or retrospective studies involving more than 50 patients with biopsy proven diagnosis and absence of dysplasia at initial diagnosis of oral lichen planus (OLP) or oral lichenoid lesions (OLL) were considered.Data extraction and synthesisTwo reviewers independently selected the studies and abstracted data. Read More

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http://www.nature.com/doifinder/10.1038/sj.ebd.6401349
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http://dx.doi.org/10.1038/sj.ebd.6401349DOI Listing
December 2018
7 Reads

Cutaneous, genital and oral lichen planus: A descriptive study of 274 patients.

Med Oral Patol Oral Cir Bucal 2019 Jan 1;24(1):e1-e7. Epub 2019 Jan 1.

Bellvitge University Campus, Department of Dental Medicine - School of Dentistry, Pabellón de Gobierno, C/. Feixa LLarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona - Spain,

Background: Lichen planus (LP) is a chronic autoimmune disease that affects the oral mucosa as well as the skin, genital mucosa and other sites.

Objective: to evaluate the correlation between oral, genital and cutaneous lichen planus, in a sample of LP patients.

Material And Methods: This descriptive study reviewed 274 clinical histories of patients, who all presented histological confirmation of lichen planus verified by a pathologist, attending research centers in Barcelona. Read More

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http://dx.doi.org/10.4317/medoral.22656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344000PMC
January 2019

Autoimmune diseases in autoimmune atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):100-103. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7919DOI Listing
December 2018
10 Reads

Successful treatment of isolated oral lichen planus on lower lip with traditional Chinese medicine and topical wet dressing: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13630

Department of Oral Medicine.

Rationale: Biopsy is very important for the diagnosis of oral lichen planus (OLP) on the lips. Traditional Chinese medicine (TCM) can be used to coordinate the whole body, soften and eliminate swellings and masses, and regulate the functions of qi and blood. Therefore, TCM could be an effective and safe treatment for OLP. Read More

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http://dx.doi.org/10.1097/MD.0000000000013630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320154PMC
December 2018
7 Reads

Topical hyaluronic acid in the management of oral lichen planus: A comparative study.

J Investig Clin Dent 2018 Dec 17:e12385. Epub 2018 Dec 17.

Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Jouf University, Sakaka, Saudi Arabia.

Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disorder seen in clinical dental practice. Despite the progress in research and advances in knowledge, the successful management of OLP is still difficult to achieve. The aim of the present study was to compare the therapeutic effects of triamcinolone (TA) preparation (0. Read More

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http://dx.doi.org/10.1111/jicd.12385DOI Listing
December 2018

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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http://www.njms.in/text.asp?2018/9/2/184/245349
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http://dx.doi.org/10.4103/njms.NJMS_49_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251297PMC
December 2018
20 Reads

Evaluation of the serum levels of galectin-3 in patients with oral lichen planus disease.

Oral Dis 2019 Mar 6;25(2):466-470. Epub 2019 Jan 6.

Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Galectin-3, a member of beta-galactoside-binding proteins, can be found in cytoplasm and nucleus as well as extracellularly in various tissues and involved in many physiological and pathological processes. We aimed to measure the serum levels of galectin-3 in oral lichen planus (OLP) disease and compare the result with that observed in healthy ones.

Materials And Methods: In this cross-sectional study, the serum levels of galectin-3 were measured in 56 healthy individuals and 53 pathologically proven OLP patients including those with atrophic/erosive (33 cases) or reticular (20 cases) lesions, using enzyme-linked immunosorbent assay (ELISA). Read More

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http://doi.wiley.com/10.1111/odi.13012
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http://dx.doi.org/10.1111/odi.13012DOI Listing
March 2019
23 Reads
2.427 Impact Factor

Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial.

Int J Dent Hyg 2018 Dec 2. Epub 2018 Dec 2.

Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.

Objectives: The aim of this randomized, parallel-design, clinical trial was to investigate the effectiveness of an intensive plaque control programme with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients.

Methods: A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group. Both groups were enrolled in an intensive control programme comprising supragingival scaling and polishing, and brush-specific instructions for a period of 8 weeks. Read More

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http://doi.wiley.com/10.1111/idh.12377
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http://dx.doi.org/10.1111/idh.12377DOI Listing
December 2018
9 Reads

Analysis of Immunologic Function Changes in Lichen Planus After Clinical Treatment.

Med Sci Monit 2018 Dec 2;24:8716-8721. Epub 2018 Dec 2.

Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, China (mainland).

BACKGROUND Lichen planus (LP) is a common chronic superficial skin lesion that causes chronic or sub-acute inflammatory disorders. LP can affect the oral cavity, skin, mucous membrane, and other body parts, and features include repeat attacks and long duration, leading to lower quality of life. This study aimed to analyze the changes of immunologic function before and after treatment of LP. Read More

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https://www.medscimonit.com/abstract/index/idArt/910931
Publisher Site
http://dx.doi.org/10.12659/MSM.910931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287452PMC
December 2018
7 Reads

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies.

Medicina (Kaunas) 2018 Dec 3;54(6). Epub 2018 Dec 3.

Oral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. Read More

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http://dx.doi.org/10.3390/medicina54060099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306895PMC
December 2018
1 Read
0.508 Impact Factor

Evaluation of Serum Desmoglein 1 and Desmoglein 3 in Oral Erosive Lichen Planus before and after Topical Application of Tacrolimus.

J Contemp Dent Pract 2018 Oct 1;19(10):1204-1213. Epub 2018 Oct 1.

Department of Oral Surgery, Maxillofacial and Diagnostic Science, College of Dentistry, Qassim University, KSA.

Aim: The current study will attempt to throw light on the role of desmoglein 1 and desmoglein 3 in the pathogenesis of erosive lichen planus and their response to topical application of tacrolimus.

Materials And Methods: Twenty patients with erosive oral lichen planus received tacrolimus ointment three times daily for eight weeks. Assessments using the clinical score and a visual analog scale were recorded at each visit. Read More

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October 2018
4 Reads