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    Experimental Study on 1,25(OH)2 D3 Amelioration of Oral Lichen Planus through Regulating NF-κB Signaling Pathway.
    Oral Dis 2017 Feb 23. Epub 2017 Feb 23.
    Department of Stomatology of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
    Objective: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it.

    Methods: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR. Read More

    Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus.
    Clin Chim Acta 2017 Feb 16;468:46-50. Epub 2017 Feb 16.
    School of Stomatology, Harbin Medical University, Harbin 151000, PR China.
    Background: Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    [Analysis of type C behavior in patients with oral lichen planus].
    Beijing Da Xue Xue Bao 2017 Feb;49(1):120-124
    Department of Oral Medicine,Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To assess type C behavior in patients with oral lichen planus (OLP) in order to provide basis for clinical prevention, treatment and psychological intervention of OLP.

    Methods: Type C behavior scale was used on 85 OLP patients and 85 control patients, who were in accordance with the inclusion criteria, in order to investigate their type C behavior. The scale included 9 items: anxiety, depression, anger, anger toward inside (anger-in), anger toward outside (anger-out), reasoning, domination, optimism, and social support. Read More

    Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus.
    Oral Dis 2017 Feb 15. Epub 2017 Feb 15.
    School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
    Objective: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control.

    Subjects And Methods: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. Read More

    Investigating the level of salivary endothelin-1 in premalignant and malignant lesions.
    Spec Care Dentist 2017 Feb 15. Epub 2017 Feb 15.
    Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
    Purpose: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions.

    Materials And Methods: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. Read More

    Salivary oxidative status in patients with oral lichen planus.
    J Physiol Pharmacol 2016 Dec;67(6):885-894
    Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.
    Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. Read More

    Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.
    Arch Oral Biol 2017 Feb 6;78:13-19. Epub 2017 Feb 6.
    Research Group of Chronic Inflammatory Oral Diseases and Systemic Diseases Associated with Oral Health, Khon Kaen University, Khon Kaen, Thailand; Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand. Electronic address:
    Objective: The existence of extra-pineal melatonin has been observed in various tissues. No prior studies of melatonin in human oral mucosal tissue under the condition of chronic inflammation have been reported. The aim of this study was to investigate the presence of melatonin in oral mucosal tissue of patients with oral lichen planus (OLP) which was considered as a chronic inflammatory immune-mediated disease causing oral mucosal damage and ulcerations. Read More

    Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?
    J Oral Pathol Med 2017 Feb 10. Epub 2017 Feb 10.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. Read More

    Most Frequent Oral Lesions in Patients with Type 2 Diabetes Mellitus.
    J Contemp Dent Pract 2017 Feb 1;18(2):107-111. Epub 2017 Feb 1.
    Department of Dentistry, Federal University of Sergipe Lagarto, Sergipe, Brazil.
    Aim: Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease.

    Materials And Methods: This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF. Read More

    Topical tacrolimus, triamcinolone acetonide and placebo in oral lichen planus: A pilot randomized controlled trial.
    Oral Dis 2017 Feb 6. Epub 2017 Feb 6.
    Institute of Dentistry, University of Oulu, Finland.
    Objective: To carry out a double-blind RCT to compare the effectiveness of topical tacrolimus (TAC), triamcinolone acetonide (TRI) and placebo (PLA) in symptomatic OLP.

    Subjects And Methods: A clinical score (CS, range 0-130) was developed to measure the clinical signs and symptoms of OLP. Twenty-seven OLP patients with a CS of ≥ 20 were randomly allocated to receive 0. Read More

    Comparison of B-Cell Activating Factor Expression in Neutrophils in Patients with Potentially Malignant Disorders and Patients with Cancer in the Same Site.
    Clin Lab 2016 Aug;62(8):1507-1514
    Background: B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC), suggesting a tumor-promoting activity of those cells. Taking into consideration that numerous OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs), involving e. Read More

    Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL?
    Med Oral Patol Oral Cir Bucal 2017 Feb 4. Epub 2017 Feb 4.
    Faculdade de Odontologia de Piracicaba - UNICAMP, Departamento de Diagnóstico Oral - Semiologia, Av. Limeira, 901 CEP 13.414-903, Piracicaba - São Paulo - Brasil,
    In their recent publication, Garcia-Pola et al. (2016) suggested the development of proliferative verrucous leukoplakia (PVL) in oral lichen planus (OLP). It was described as a preliminary study, where this association supposedly occurred (1). Read More

    The use of topical corticosteroides in the treatment of oral lichen planus in Spain: A national survey.
    Med Oral Patol Oral Cir Bucal 2017 Feb 4. Epub 2017 Feb 4.
    Eduardo Anitua Foundation, C/ Jose Maria Cagigal 19, 01007 Vitoria, Spain
    Background: Explore the treatment of oral lichen planus with topical corticosteroids by the healthcare professionals in Spain.

    Material And Methods: A questionnaire targeted health professionals who treat OLP, in particular maxillofacial surgeons, dermatologist and dentist. The dissemination of the questionnaires was conducted through professional associations and dental and medical societies. Read More

    Autoimmune Disease Manifestations in the Oral Cavity.
    Surg Pathol Clin 2017 Mar 28;10(1):57-88. Epub 2016 Dec 28.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA.
    Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns. Read More

    Swiss Dent J 2017 ;127(1):27-37
    Poliklinik für Zahnärztliche Prothetik und Werkstoffkunde, Universitätsklinikum Leipzig, Leipzig, Germany.
    Allergen-triggered lichenoid oral mucosa lesions may occur both in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Clinically, OLP and OLL are difficult to distinguish from each other. An OLP should be checked by histological examination. Read More

    Next step: functional studies on hypertension, lichen planus and TRPA1 connections.
    Oral Dis 2017 Jan 28. Epub 2017 Jan 28.
    Department of Pharmacology and Pharmacotherapy, University of Pecs Medical School, Pecs, Hungary.
    We would like to thank for the invaluable insights of Shan and colleagues (Shan et al, 2017). They put forward a most logical hypothesis for a link between Koebner phenomenon and the mechanoreceptor Transient Receptor Potential Ankyrin 1 (TRPA1). As suggested, TRPA1 expression in non-lesion mucosal areas of oral lichen planus (OLP) patients should also be investigated. Read More

    Increased circulating CXCR5(+) CD4(+) T follicular helper-like cells in oral lichen planus.
    J Oral Pathol Med 2017 Jan 25. Epub 2017 Jan 25.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
    Background: CD4(+) T helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T helper cells, has been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated. Read More

    A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series.
    Photodiagnosis Photodyn Ther 2017 Jan 21. Epub 2017 Jan 21.
    Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland; Dental Practice, ul. Waszyngtona 1/34, 15-269 Białystok, Poland.
    Background: Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of EOLP. Read More

    Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis.
    Vet Pathol 2017 Jan 1:300985816688754. Epub 2017 Jan 1.
    3 Department of Pathology, Microbiology and Immunology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA.
    Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Read More

    Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products.
    Clin Oral Investig 2017 Jan 13. Epub 2017 Jan 13.
    Section for Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Medical and Health Sciences, University of Copenhagen, 20 Noerre Allé, 2200, Copenhagen N, DK, Denmark.
    Objective: Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact allergies to dental materials and oral hygiene products in these patients.

    Methods: Forty-nine patients (7 men, 42 women) aged 31 to 77 years (61 ± 10. Read More

    Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
    Medicine (Baltimore) 2017 Jan;96(2):e5075
    aDepartment of Dental Surgery bDepartment of Endocrinology, Brest University Hospital, Brest cDepartment of Dermatology, Quimper Hospital, Quimper dDepartment of Oral Surgery, Brest University Hospital, Brest, France.
    Background: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Read More

    Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study.
    Acta Inform Med 2016 Dec;24(6):390-393
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.

    Methods: In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Read More

    Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients.
    Braz Oral Res 2017 Jan 5;31:e10. Epub 2017 Jan 5.
    Isfahan University of Medical Sciences, Department of Oral and Maxillofacial Medicine, Isfahan, Iran.
    This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. Read More

    Genome-wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis C Virus Infection.
    Clin Gastroenterol Hepatol 2017 Jan 5. Epub 2017 Jan 5.
    Department of Virology, Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
    Background & Aims: There is a close relationship between hepatitis C virus (HCV) infection and lichen planus, a chronic inflammatory muco-cutaneous disease. We performed a genome-wide association study (GWAS) to identify genetic variants associated with HCV-related lichen planus.

    Methods: We conducted a GWAS of 261 patients with HCV infection treated at a tertiary medical center in Japan from October 2007 through January 2013; 71 had lichen planus and 190 had normal oral mucosa. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Interventions for the management of Oral lichen planus: A review of the conventional and novel therapies.
    Oral Dis 2017 Jan 5. Epub 2017 Jan 5.
    Department of Oral Medicine & Radiology, Maulana Azad Institute of Dental Sciences, New Delhi.
    Objective: This narrative review focuses on the rationale & role of conventional and newer therapies in the management of Oral lichen planus with emphasis on randomized controlled trials reported over 2 decades.

    Materials And Methods: Literature search was conducted to identify randomized controlled trials for management of OLP from 1/1/1995 to 31/12/2015; Medline, and Cochrane databases complemented with manual search was used. Primary outcome as resolution of pain was evaluated with analysis of clinical resolution of erythema and ulceration as secondary outcome. Read More

    Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma.
    Mediators Inflamm 2016 8;2016:5715719. Epub 2016 Dec 8.
    Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
    Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions-oral leukoplakia (OLK) and oral lichen planus (OLP)-to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. Read More

    Histologic Assessment of Lichenoid Dermatitis Observed in Patients With Advanced Malignancies on Antiprogramed Cell Death-1 (anti-PD-1) Therapy With or Without Ipilimumab.
    Am J Dermatopathol 2017 Jan;39(1):23-27
    *Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia; †Department of Dermatology, Westmead Hospital, Sydney, Australia; and ‡Sydney Medical School, University of Sydney, Sydney, Australia.
    Lichenoid drug reaction is a common adverse reaction in patients taking immune-modulatory agents such as antiprogramed cell death (PD-1) and cytotoxic T lymphocyte antigen-4 agents. The authors describe the clinical and histologic features of lichenoid drug reaction in 20 biopsies from 15 patients on anti-PD-1 agents and 9 biopsies from 7 patients on anti-PD-1 plus ipilimumab therapy. Clinically, all except 2 patients presented with discrete, violaceous exanthematous papules to plaques. Read More

    Vulvovaginal gingival lichen planus: report of two cases and review of literature.
    Oral Implantol (Rome) 2016 Apr-Jun;9(2):54-60. Epub 2016 Nov 13.
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
    Purpose: Oral Lichen Planus (OLP) is a chronic inflammatory disease of skin and mucous membranes. Approximately 20% of women with oral lichen planus develops lesions in the genital mucosa. In 1982, Pelisse described a special form of lichen planus (LP), which consists of a triad of symptoms: vulval, vaginal and gingival (VVG)-LP lesions. Read More

    The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis.
    Oral Dis 2016 Dec 28. Epub 2016 Dec 28.
    Department of Chemistry, School of Sciences and Engineering, American University in Cairo, Cairo, Egypt.
    Objectives: The main objective of oral lichen planus management is to control symptomatic outbreaks via eliminating lesions and alleviating symptoms. Corticosteroids, calcineurin inhibitors, and most of the available modalities are associated with adverse effects, which may limit their use. The aim of this review was to assess the effect of aloe vera on pain alleviation and/or clinical improvement in patients with symptomatic oral lichen planus. Read More

    Allelic loss in amalgam-associated oral lichenoid lesions compared to oral lichen planus and mucosa.
    Oral Dis 2016 Dec 27. Epub 2016 Dec 27.
    Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
    Background: The amalgam-associated oral lichenoid lesion (AAOLL) shows clinical and histopathological features similar to oral lichen planus (OLP). Molecular researches to improve knowledge of pathogenesis and clinical behavior of AAOLL are still scarce.

    Objective: We investigated for the first time the use of loss of heterozygosity (LOH) as a molecular approach for genetic characterization of AAOLL in comparison with OLP and evaluated the cell proliferation index. Read More

    Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls.
    J Eur Acad Dermatol Venereol 2016 Dec 21. Epub 2016 Dec 21.
    Department of Odontology, Oral Pathology and Oral Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
    Background: Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology affecting the skin and oral mucosa. Oral lichenoid lesions (OLLs), like oral contact reactions, may resemble oral lichen planus (OLP) both clinically and histopathologically. As OLP and OLL are hyperkeratotic diseases and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in these lesions. Read More

    Oral lichen planus: therapy and phenotype.
    G Ital Dermatol Venereol 2016 Dec 16. Epub 2016 Dec 16.
    Department of Otolorology and Maxillo-Facial Surgery, F. Tappeneir Hospital Merano, Bolzano, Italy.
    Background: Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature. Although many therapeutic options are available, none are curative. The aim of this article was to describe a therapeutic algorithm that take into consideration the clinical futures of oral LP (OLP). Read More

    [Histopathological analysis of oral lichen planus with malignant transformation].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2016 Dec;51(12):717-721
    Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To estimate the histological features of oral lichen planus (OLP) which underwent malignant transformation and discuss the current problems in OLP pathological diagnosis. Methods: Using the modified WHO OLP criteria (2003), reevaluated the pathological changes of cases diagnosed initially as OLP and transformed into squamous cell carcinomas indicated by subsequent biopsies. Results: Among 3 721 cases of OLP clinically and pathologically diagnosed during 1984 and 2015, there were 19 cases (0. Read More

    The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients.
    J Clin Exp Dent 2016 Dec 1;8(5):e566-e570. Epub 2016 Dec 1.
    PhD. Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University.
    Background: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed for management of symptomatic OLP. Read More

    [Precancerous lesions of the buccal epithelium].
    Ann Dermatol Venereol 2017 Feb 6;144(2):100-108. Epub 2016 Dec 6.
    Service de pathologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
    Squamous cell carcinomas of the oral cavity and lips consistently have a high incidence (they constitute the fifth most common form of cancer in France) and carry a heavy prognosis, particularly if diagnosed late. According to different studies, between 10 and 80% of such carcinomas occur in a pre-existing or precancerous lesion. The World Health Organisation (WHO) recommends the use of two terms for such lesions: precursor lesions, i. Read More

    Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report.
    Case Rep Gastroenterol 2016 Sep-Dec;10(3):617-622. Epub 2016 Oct 28.
    Department of Organ System Interactions and Information, Saga Medical School, Saga, Japan; Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Fukuoka, Japan.
    Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. Read More

    Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study.
    J Laryngol Otol 2017 Jan 5;131(1):69-76. Epub 2016 Dec 5.
    Department of ENT, Head & Neck Surgery,Moti Lal Nehru Medical College,Allahabad,India.
    Objective: This study compared the therapeutic efficacy of steroidal and non-steroidal agents for treating oral lichen planus.

    Methods: Forty patients with clinical and/or histologically proven oral lichen planus were randomly placed into four groups and treated with topical triamcinolone, oral dapsone, topical tacrolimus or topical retinoid for three months. Pre- and post-treatment symptoms and signs were scored for each patient. Read More

    Identification of AgNORs and cytopathological changes in oral lichen planus lesions.
    Acta Histochem 2017 Jan 1;119(1):32-38. Epub 2016 Dec 1.
    Graduate Program in Dentistry, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155, Curitiba, Pr 80215-901, Brazil. Electronic address:
    Objective: To evaluate cytopathological changes in epithelial cells of the oral mucosa of patients with oral lichen planus (OLP) compared with patients without OLP.

    Subjects And Methods: Swabs were collected from the oral mucosa of 20 patients with OLP (case group) and 20 patients without OLP (control group) using liquid-based cytology. After Papanicolaou staining, the smears were characterized based on Papanicolaou classification and degree of maturation. Read More

    Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression.
    Behav Brain Res 2017 Mar 29;320:136-142. Epub 2016 Nov 29.
    Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China; Heilongjiang Academy of Medical Sciences, Harbin 150001, Heilongjiang, China. Electronic address:
    Exacerbations of oral lichen planus (OLP) have been linked to the periods of psychological stress, anxiety and depression. The specific mechanism of the interaction is unclear. The aim of this study was to explore the candidate genes or molecules that play important roles in the interaction between OLP and depression. Read More

    Elucidating the role of Cyclooxygenase-2 in the pathogenesis of oral lichen planus - an immunohistochemical study with supportive histochemical analysis.
    J Oral Pathol Med 2016 Nov 7. Epub 2016 Nov 7.
    Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.
    Objective: Oral lichen planus (OLP) is a chronic, inflammatory disorder that affects the oral mucous membrane. During an inflammatory response, several chemokines and cytokines are released by the cells of the immune system. Activation of MMPs, along with mast cell-derived chymase and tryptase, degrades the basement membrane structural proteins, resulting in basement membrane breaks. Read More

    Low-level Laser Therapy: A Review of Its Applications in the Management of Oral Mucosal Disorders.
    Altern Ther Health Med 2016 Nov;22(6):24-31
    Due to its analgesic, anti-inflammatory, and biostimulating effects, low-level laser therapy (LLLT) has been widely used for oral disorders, such as oral lichen planus (OLP), xerostomia, recurrent aphthous stomatitis (RAS), herpes labialis, burning mouth syndrome (BMS), and oral mucositis (OM). The research team for the present study has reviewed the literature on the subject, with an emphasis on the applicability of LLLT in general and of its various clinical protocols for the management of those oral disorders. In lesions such as the ones occurring in OM, RAS, herpes labialis, and OLP, the course of wound healing and the pain have been shown to decrease, with a few, or most often, no adverse side effects. Read More

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