4,316 results match your criteria Oral Lichen Planus


Psychological disorders and quality of life in oral lichen planus patients and a control group.

Oral Dis 2019 Apr 16. Epub 2019 Apr 16.

Oral Medicine, Oral Surgery and Implantology Unit. Faculty of Medicine and Dentistry., Santiago de Compostela, Spain.

Objectives: oral lichen planus (OLP) is a common disease whose aetiopathogenesis is linked to psychological disorders. This study aims to determine the influence of anxiety and depression in OLP patients, define the perception of quality of life in these patients and check for potential differences between atrophic/ ulcerative and reticular lesions.

Material And Methods: a group of 48 OLP patients and a control group of 40 patients were selected. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13106
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http://dx.doi.org/10.1111/odi.13106DOI Listing
April 2019
1 Read

Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety.

Clin Oral Investig 2019 Apr 15. Epub 2019 Apr 15.

Department of Stomatology, Public Oral Health and Forensic Dentistry, Division of Oral Diagnosis, School of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.

Objectives: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are chronic inflammatory diseases whose symptoms can impair patient's quality of life (QoL). Psychological factors seem to play an important role in these diseases. This study aimed to determine the impact of oral health and anxiety levels on the QoL of patients with OLP and OLL. Read More

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http://link.springer.com/10.1007/s00784-019-02892-2
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http://dx.doi.org/10.1007/s00784-019-02892-2DOI Listing
April 2019
2 Reads

Generalized Licen Planus Treated With Narrowband UV-B Phototherapy: Results From 10 Patients and a Review of the Literature.

Actas Dermosifiliogr 2019 Apr 13. Epub 2019 Apr 13.

Servicio de Dermatología, Hospital Universitario Sanitas La Zarzuela, Universidad Francisco de Vitoria, Madrid, España.

Generalized lichen planus can be difficult to treat. One alternative for patients who do not respond to common topical and systemic treatments, such as corticosteroids and oral antihistamines, is phototherapy. Narrowband UV-B phototherapy offers several advantages and is currently the main treatment modality. Read More

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http://dx.doi.org/10.1016/j.ad.2018.01.015DOI Listing

Zinc Therapy in Treatment of Symptomatic Oral Lichen Planus.

Indian Dermatol Online J 2019 Mar-Apr;10(2):174-177

Department of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.

Lichen planus is a chronic inflammatory disease, which involves skin, mucous membrane, and nails. Prevalence of oral lichen planus varies between 0.5% and 2. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_230_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434769PMC
April 2019
1 Read

Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland.

Human β-defensin 2 (hBD-2) is a potent antimicrobial peptide that participates in defense against invading bacteria. We recently showed that bacterial components and histamine, through histamine H4 receptor (H4R), are involved in the pathogenesis of the potentially malignant lesion, oral lichen planus (OLP). However, the underlying mechanisms remain unknown. Read More

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http://dx.doi.org/10.3390/ijms20071780DOI Listing
April 2019
1 Read

Down-regulation of miRNA-27b-3p suppresses keratinocytes apoptosis in oral lichen planus.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Oral lichen planus (OLP) is considered a precancerous lesion with no known cure. Recent studies reported that abnormal regulation of apoptosis was involved in the pathogenesis of OLP. Next generation sequencing was used to screen the candidate microRNAs and genes in biopsies from patients with OLP and healthy mucosa. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14324
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http://dx.doi.org/10.1111/jcmm.14324DOI Listing
April 2019
2 Reads

Insight into verruciform xanthoma with oral submucous fibrosis: Case report and review of literature.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):43-48

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Dilsukhnagar, Hyderabad, Telangana, India.

Verruciform xanthoma (VX) is a rare benign mucocutaneous verrucopapillary lesion, which mainly involves masticatory mucosa and gingiva. Clinically, it presents as a solitary, sessile or pedunculated, white- or yellow-white-colored growth with a pebbled surface, hence often misdiagnosed as papilloma. The hallmark of histological diagnosis is the presence of foam cells or xanthoma cells confined to the connective tissue papillae. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_210_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421923PMC
February 2019
5 Reads

Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus.

PLoS One 2019 9;14(4):e0215055. Epub 2019 Apr 9.

Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany.

Head and neck squamous cell carcinoma (HNSCC) affects about 700.000 individuals per year worldwide with oral squamous cell carcinoma (OSCC) as a major subcategory. Despite a comprehensive treatment concept including surgery, radiation, and chemotherapy the 5-year survival rate is still only about 50 percent. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215055PLOS

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

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http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

Effects of oral healthcare motivation in patients with gingival oral lichen planus: a randomized controlled trial.

Oral Dis 2019 Apr 4. Epub 2019 Apr 4.

Centro Universitario di Odontoiatria, Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy.

Objectives: The role of dental plaque in gingival lesions caused by oral lichen planus has not been fully defined. The aim of this clinical trial was to evaluate the effects of oral healthcare motivation on clinical variables in patients with gingival oral lichen planus.

Materials And Methods: Oral lichen planus patients with symptomatic gingival lesions were randomized in control and intervention groups. Read More

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http://dx.doi.org/10.1111/odi.13104DOI Listing
April 2019
1 Read

Changing epidemiology of HCV infection in patients with oral lichen planus in north-west Italy.

Oral Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1111/odi.13099DOI Listing

Relationship of infiltrating intraepithelial T lymphocytes in the diagnosis of oral lichen planus versus oral epithelial dysplasia: a pilot study.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 13. Epub 2019 Feb 13.

Kaneda Family Distinguished Associate Professor, Oral and Maxillofacial Pathology, Department of Diagnostic Sciences, University of North Carolina at Chapel Hill, School of Dentistry, 101 Manning Drive, Chapel Hill, NC, USA.

Objective: The aim of this study was to identify the type and distribution of CD4+ and CD8+ T lymphocytes in oral mucosal specimens to potentially distinguish between underlying alterations or patterns in oral epithelial dysplasia and oral lichen planus.

Study Design: This pilot study included 10 archived tissue samples that were received at the University of North Carolina Oral and Maxillofacial Pathology Laboratory and were diagnosed as oral lichen planus and moderate to severe epithelial dysplasia. Dual staining with CD4 and CD8 antibodies was carried out on each case. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.02.004DOI Listing
February 2019
1 Read

Treatment effectiveness of levamisole plus prednisolone on oral lichen planus patients with emphasis on levamisole-induced agranulocytosis or pancytopenia.

J Formos Med Assoc 2019 Mar 25. Epub 2019 Mar 25.

Oral Pathology and Family Dentistry Section, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background/purpose: Physicians' and dentists' knowledge of levamisole-induced agranulocytosis or pancytopenia remains incomplete. This study aimed to evaluate the treatment effectiveness of levamisole plus prednisolone on oral lichen planus (OLP) patients with emphasis on levamisole-induced hematological changes.

Methods: Ninety patients with erosive OLP were given 120 mg/day new levamisole (Levazol) and 15 mg/day prednisolone for three consecutive days each week. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.007DOI Listing
March 2019
3 Reads

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.

Eur J Cancer Prev 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine, University of Tennessee Health Science Centre, Memphis, Tennessee, USA.

Around 300 000 patients are estimated to have oral cancer worldwide annually, and the incidence is higher in South Asian countries. In 2005, at the Congress of WHO, the term potentially malignant disorder (PMD)/lesion was suggested as a replacement for premalignant oral lesions and conditions. PMDs are those lesions of the oral mucosa that are at an increased risk of malignant transformation compared with the healthy mucosa. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000510DOI Listing

Differential diagnosis of leukoplakia versus lichen planus of the oral mucosa based on digital texture analysis in intraoral photography.

Adv Clin Exp Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Maxillofacial Surgery, Faculty of Military Medicine, Medical University of Lodz, Poland.

Background: A noninvasive, accurate and quick diagnosis is very important to general practitioners and specialists who care for the health of patients' oral cavity mucosa. The main enemies are precancerous lesions: leukoplakia and lichen planus (LP).

Objectives: The aim of this study was to attempt to formulate a differential diagnosis for leukoplakia vs LP in the oral mucosa based on digital texture analysis in intraoral macrophotography. Read More

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http://dx.doi.org/10.17219/acem/104524DOI Listing

Implications on pathogenesis and risk of oral lichen planus neoplastic transformation: an ex-vivo retrospective immunohistochemical study.

Histol Histopathol 2019 Mar 25:18104. Epub 2019 Mar 25.

Pathology Unit, Ospedale "Sant'Andrea", DiMeT, UPO, Vercelli, Italy.

Aims: to evaluate OPN, MCM7, Ki-67, p53, Bcl-2 and 53BP1 presence, together with the abnormal adaptive CD4 and CD8 T-cell response markers expression in a series of oral lichen planus (OLP) affected patients and assess their combined contribution for a more objective disease classification.

Methods And Results: In this ex-vivo retrospective analysis, biopsy specimens from 28 adults with a clinical diagnosis of OLP at different progression degree (16 reticular, 2 plaque-like, 1 erosive and 9 mixed type) were collected. Sections were immunohistochemically investigated for the proinflammatory cytokine osteopontin (OPN), alpha-beta CD4 and CD8 positive T cells, DNA replication licensing factor (MCM7), proliferating cell marker (Ki-67), apoptotic and tumor antigen (p53), apoptosis modulator (Bcl-2) and cellular response regulator to double-strand breaks tumor suppressor p53-binding protein 1 expression. Read More

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http://dx.doi.org/10.14670/HH-18-104DOI Listing
March 2019
1 Read

Rate of actual metal allergy prior to dental treatment in subjects complaining of possible metal allergy.

Asian Pac J Allergy Immunol 2019 Mar 24. Epub 2019 Mar 24.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Dental treatment for patients with self-reported metal allergy or concern about the possibility of having such an allergy is often difficult; such patients often undergo dermatological consultations for metal patch test (PT).

Objective: This study compared PT results for metal allergens and the clinical relevance of this among patients visiting Fukuoka Dental College Hospital.

Methods: We performed PT with metal allergens on patients with oral mucosa- or skin-related symptoms, or those concerned about adverse events associated with upcoming dental treatment. Read More

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http://dx.doi.org/10.12932/AP-241018-0425DOI Listing

Topical calcineurin inhibitors in the treatment of oral lichen planus: a systematic review and meta-analysis.

Br J Dermatol 2019 Mar 22. Epub 2019 Mar 22.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.

Background: TCS (topical corticosteroids) is the first-line drug in the treatment of oral lichen planus (OLP). However, the value of topical calcineurin inhibitors (TCI) including tacrolimus, pimecrolimus and cyclosporine for OLP is still controversial.

Objectives: The article was carried out to compare the efficacy and safety of TCI with TCS for OLP. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17898
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http://dx.doi.org/10.1111/bjd.17898DOI Listing
March 2019
11 Reads

Time trend in the prevalence of oral lichen planus based on Taiwanese National Health Insurance Research Database 1996-2013.

J Dent Sci 2018 Sep 13;13(3):274-280. Epub 2018 Jul 13.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Background/purpose: Oral lichen planus (OLP) is a common chronic inflammatory disease characterized by a T cell-mediated immune response against epithelial cells. The epidemiological survey of OLP in Taiwanese population was scarce. In this study, we investigated the time trend of prevalence stratified by gender, age, urbanization, and income of OLP based on National Health Insurance Research Database (NHIRD). Read More

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http://dx.doi.org/10.1016/j.jds.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388843PMC
September 2018
1 Read

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature.

Curr Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. India.

Oral cancer (OC) is a serious and a growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in expected number of new cases in US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Read More

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http://www.eurekaselect.com/170833/article
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http://dx.doi.org/10.2174/1389450120666190319125734DOI Listing
March 2019
7 Reads

Oral Epithelial Dysplasia and Premalignancy.

Authors:
Sook-Bin Woo

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Harvard School of Dental Medicine, Boston, MA, USA.

Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years. Importantly, traumatic/frictional keratoses are often mistaken clinically for leukoplakia and it is important for the pathologist to recognize and report them as such. The features of OED have been well-described and other architectural features will be discussed here, in particular verrucous and papillary architecture, bulky epithelial proliferation and epithelial atrophy. Read More

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http://dx.doi.org/10.1007/s12105-019-01020-6DOI Listing
March 2019
2 Reads

Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, , Green Tea and Coffee Properties.

Biomolecules 2019 03 17;9(3). Epub 2019 Mar 17.

Food Safety Research Center (Salt), Semnan University of Medical Sciences, Semnan 35198-99951, Iran.

Oral mucosal lesions have many etiologies, including viral or bacterial infections, local trauma or irritation, systemic disorders, and even excessive alcohol and tobacco consumption. Folk knowledge on medicinal plants and phytochemicals in the treatment of oral mucosal lesions has gained special attention among the scientific community. Thus, this review aims to provide a brief overview on the traditional knowledge of plants in the treatment of oral mucosal lesions. Read More

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http://dx.doi.org/10.3390/biom9030106DOI Listing

Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review.

Cureus 2018 Dec 31;10(12):e3802. Epub 2018 Dec 31.

Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, IND.

Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in India and most other developing countries. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Hence, these patients warrant regular screening by oral health care professionals and proper monitoring for any dysplastic changes. Read More

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http://dx.doi.org/10.7759/cureus.3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402749PMC
December 2018
1 Read

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study.

J Dent (Tehran) 2018 Nov;15(6):358-364

Senior Lecturer, Department of Oral Medicine & Radiology, G Pullareddy Dental College & Hospital, Kurnool, Andhra Pradesh, India.

Objectives: The aim was to evaluate and compare pretreatment serum C-reactive protein (CRP) levels in patients with oral premalignancies and malignancies with that in healthy controls.

Materials And Methods: The study sample consisted of 90 patients of both genders. The subjects were divided into three groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399459PMC
November 2018
5 Reads

Clinical Management of Oral Lichen Planus: A Systematic Review.

Mini Rev Med Chem 2019 Mar 1. Epub 2019 Mar 1.

University of Milan-Bicocca. Italy.

Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment.

Materials And Methods: We searched and analyzed PubMed database for articles on OLP management. Read More

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http://www.eurekaselect.com/170373/article
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http://dx.doi.org/10.2174/1389557519666190301144157DOI Listing
March 2019
3 Reads
2.903 Impact Factor

Prevalence of oral mucosal lesions among smokeless tobacco usage: A cross-sectional study.

Indian J Cancer 2018 Oct-Dec;55(4):404-409

Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.

Background: Tobacco use is one of the most prevalent forms of habit and associated with development of potential malignant disorders. The aim of the present study was to investigate the prevalence and distribution of oral mucosal lesions (OMLs) among smokeless tobacco users.

Materials And Methods: This is a hospital-based cross-sectional study. Read More

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http://dx.doi.org/10.4103/ijc.IJC_178_18DOI Listing
March 2019
7 Reads

Implants in patients with oral manifestations of autoimmune or muco-cutaneous diseases - A systematic review.

Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e217-e230. Epub 2019 Mar 1.

Charité - Universitaetsmedizin Berlin, Charité Centre 3 for Dental, Oral, and Maxillary Medicine, Department for Oral Medicine Dental Radiology, and Oral Surgery, Assmannshauser Str. 4-6, 14197 Berlin, Germany,

Background: To give an overview on implant survival rates in patients with oral manifestations of systemic autoimmune (oral Lichen planus (oLp), Pemphigus (Pe)), muco-cutaneous (Epidermolysis bullosa (EB)), autoimmune multisystemic rheumatic diseases (Sjögren's syndrome (SjS), systemic Lupus erythematosus (sLE), or systemic Sclerosis (sSc)).

Material And Methods: Systematic literature review (PubMed/Medline, Embase) using MESH and search term combinations, published between 1980 and August 2018 in English language reporting on dental implant-prosthetic rehabilitation of patients with oLp, Pe, EB, SjS, sLE, sSc, study design, age, gender, follow-up period (≥ 12 months), implant survival rate. Implant-related weighed mean values of implant survival rate (wmSR) were calculated. Read More

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http://www.medicinaoral.com/medoralfree01/aop/22786.pdf
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http://dx.doi.org/10.4317/medoral.22786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441598PMC
March 2019
7 Reads

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review.

Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e136-e144. Epub 2019 Mar 1.

Department of Oral Medicine, Faculty of Medicine and Sciences of the Health, Julian Clavería, 33006 Oviedo, Spain,

Background: The aim of this present article was to evaluate the scientific evidence on the efficacy of daily hygiene and professional prophylaxis for treatment of desquamative gingivitis.

Material And Methods: The present systematic review was conducted following the PRISMA protocol. Searches were carried out in Pubmed, Embase, Web of Science and Cochrane Library up to July 2018, randomized clinical trials and cohort studies on desquamative gingivitis (DG), and oral diseases joined to DG. Read More

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http://dx.doi.org/10.4317/medoral.22782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441599PMC
March 2019
2 Reads

Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway.

Cell Commun Signal 2019 02 27;17(1):18. Epub 2019 Feb 27.

Department of Oral Medicine, Shanxi Medical University School and Hospital of Stomatology, NO. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.

Background: Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apoptosis by regulating microRNA-802 and p53-upregulated modulator of apoptosis (PUMA), but its roles in oral epithelial inflammatory responses in OLP are still unknown. Herein, we identify lipopolysaccharide (LPS) is able to enhance interferon gamma (IFNγ) and interleukin-1 beta (IL-1β) productions in human oral keratinocytes (HOKs) dependent on hypoxia-inducible factor-1α (HIF-1α). Read More

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http://dx.doi.org/10.1186/s12964-019-0331-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391768PMC
February 2019

Correlation between clinical and pathological features of oral lichen planus: A retrospective observational study.

Medicine (Baltimore) 2019 Feb;98(8):e14614

Department of Pathology, Clinical Hospital, Santiago de Compostela, Spain.

Oral lichen planus (OLP) is a common, chronic, inflammatory disease of autoimmune origin. The aim of this study is to determine the correlation of the histopathological features with clinical aspects and variants of OLP.We have retrospectively studied a group of 59 adult patients with confirmed clinical and histopathological diagnosis of OLP from the Oral Pathology Unit of the University of Santiago de Compostela (Spain). Read More

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http://dx.doi.org/10.1097/MD.0000000000014614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408116PMC
February 2019

Observational Molecular Case-Control Study of Genetic Polymorphisms 1 in Programmed Cell Death Protein-1 in Patients with Oral Lichen Planus

Asian Pac J Cancer Prev 2019 Feb 26;20(2):421-424. Epub 2019 Feb 26.

Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz. Email:

Background: The association between programmed cell death protein 1 (PD-1) variations and susceptibility to autoimmune diseases has been recurrently reported. However, there is no report about its relationship with oral lichen planus (OLP) as one of autoimmune diseases. Methods: We investigated the association between genetic predisposition to OLP and two single nucleotide polymorphisms in PD-1. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.421DOI Listing
February 2019
1 Read

Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection.

Oral Dis 2019 May 15;25(4):1100-1106. Epub 2019 Mar 15.

Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Objective: To verify whether there are differences between populations of CD8 + and FoxP3 + T cells in lesions of oral lichen planus associated with hepatitis C virus chronic infection (OLP-HCV) and lesions of idiopathic oral lichen planus (OLP-I).

Materials And Methods: A case-control study was performed using a convenience sample of 11 paraffin-embedded tissue blocks of OLP-HCV and 19 of OLP-I. Histological sections stained with haematoxylin and eosin were used to classify the intensity of inflammatory infiltrate. Read More

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http://dx.doi.org/10.1111/odi.13069DOI Listing
May 2019
2 Reads

Reticular and erosive oral lichen planus have a distinct metabolomic profile: A preliminary study using gas chromatography-mass spectrometry.

J Oral Pathol Med 2019 Feb 23. Epub 2019 Feb 23.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Background: Oral Lichen Planus is a chronic inflammatory disorder that affects the oral mucosa, with the reticular and erosive forms representing the primary clinical variants of the disease. Previous studies have shown that metabolic alterations may well be involved in the pathogenesis of the disease; however, the molecular mechanisms related to the clinicopathological differences between erosive and reticular forms remain unknown.

Methods: A comparative metabolomic analysis was performed on formalin-fixed and paraffin-embedded tissue samples of erosive (n = 6) and reticular (n = 10) oral lichen planus using gas chromatography-mass spectrometry. Read More

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http://dx.doi.org/10.1111/jop.12842DOI Listing
February 2019
1 Read

Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus.

Genet Mol Biol 2019 Jan-Mar;42(1):9-14. Epub 2019 Feb 21.

Department of Surgical, Medical and Health Sciences, University of Trieste, Trieste, Italy.

Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of the innate immune response and an acute-phase protein able to activate the complement cascade, was investigated to assess a possible association with OLP susceptibility in Italian patients. Two variations at the promoter region (called H/L and X/Y) and three at the first exon (at codon 52, 54, and 57) of the MBL2 gene were analyzed in 69 OLP patients and 244 healthy controls from northeastern Italy. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2018-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428121PMC
February 2019
1.202 Impact Factor

Artificial nail wearing: Unexpected elicitor of allergic contact dermatitis, oral lichen planus and risky arthroplasty.

Contact Dermatitis 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology and Allergology, Ludwig-Maximilian University Munich, Munich, Germany.

Despite the increasing use of (meth)acrylates both in dentistry and beauty treatments allergic reactions may often not be identified as such. We report a patient who developed dermatitis upon use of acrylate finger nails and exposure to paint dust followed by oral pain and erosive lichen planus due to acrylate based dental fillings. Subsequently the patient was seeking advice as dental implants and a cemented arthroplasty were planned. Read More

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http://dx.doi.org/10.1111/cod.13250DOI Listing
February 2019
3 Reads

Koebnerization of Eruptive Keratoacanthoma Into Lesions of Classic Lichen Planus Treated With Oral Acitretin.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

DermSurgery Associates, Houston, Texas Dermatology Associates of Sugar Land, Sugar Land, Texas DermSurgery Associates, Houston, Texas Department of Medicine Houston Methodist Hospital, Houston, Texas Department of Dermatology, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1097/DSS.0000000000001793DOI Listing
February 2019
3 Reads

Comorbidities in Lichen Planus: A Case-control Study in Indian Patients.

Indian Dermatol Online J 2019 Jan-Feb;10(1):34-37

Department of Dermatology, Maharajah's Institute of Medical Sciences, Nellimarla, Vizianagaram, Andhra Pradesh, India.

Background: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection.

Materials And Methods: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_48_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362740PMC
February 2019
1 Read

Evaluation of polymorphism of protein codon 72 in oral lichen planus by PCR technique.

J Dent Res Dent Clin Dent Prospects 2018 19;12(4):245-251. Epub 2018 Dec 19.

Department of Genetics, Research and Clinical Center for Infertility, Shahid Sadoughi Medical Sciences University, Yazd, Iran.

Our research was aimed to study protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Seventy paraffin-embedded tissue samples (30 OLP, 20 OSCC and 20 IFH) were studied. DNA was purified and amplified using allele-specific polymerase chain reaction to detect polymorphism. Read More

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http://dx.doi.org/10.15171/joddd.2018.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368942PMC
December 2018

In vivo reflectance confocal microscopy of oral lichen planus.

Int J Dermatol 2019 Feb 17. Epub 2019 Feb 17.

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: In vivo reflectance confocal microscopy (RCM) is an imaging technique that can virtually biopsy vital tissues, noninvasively and in real time. It results in horizontal virtual slices at a microscopic resolution that correlates well with conventional histopathology. Despite the widespread use of RCM in dermatology, it is still rarely applied to the study of oral pathologies. Read More

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http://dx.doi.org/10.1111/ijd.14410DOI Listing
February 2019
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[DNA cytometry of exfoliated cells in the diagnosis of oral potential malignant disorders].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):16-20

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the diagnostic efficiency of oral mucosa disease, especially oral squamous cell carcinoma (OSCC) and oral potential malignant disorders (OPMDs) by DNA cytometry compared with histopathological diagnosis, so as to find a convenient, simple and low-invasive method for screening and follow-up.

Methods: 203 subjects with OSCC, OPMDs and other oral mucosa disease without dysplasia according to the inclusion criteria and exclusion criteria were recruited from Peking University School and Hospital of Stomatology. The mean age was (52. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.004DOI Listing
February 2019
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Aberrant IGF1-PI3K/AKT/MTOR signaling pathway regulates the local immunity of oral lichen planus.

Immunobiology 2019 Feb 10. Epub 2019 Feb 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, PR China. Electronic address:

Objectives: Oral lichen planus (OLP) is a T cell-mediated immune-related chronic disease, featured by accumulation of T cells and apoptosis of keratinocytes. Insulin-like growth factors 1 (IGF1) signaling, in combination with its downstream PI3K/AKT/MTOR cascade, plays pivotal roles in the regulation of inflammation and immune response. Meanwhile, TRB3 acts as a connective protein in the pathway. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.004DOI Listing
February 2019

Oral lichen planus and lichen planopilaris complicated with thymoma.

J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14812DOI Listing
February 2019
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Expression of Cluster of Differentiation 1a-Positive Langerhans Cells in Oral Lichen Planus.

Indian J Dermatol 2019 Jan-Feb;64(1):41-46

Department of Oral Pathology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India.

Background/purpose: Lichen planus is a T-cell-mediated mucocutaneous disorder characterized histopathologically by a band of chronic inflammatory cells in the subepithelial zone and degeneration of basal layer. The present study was aimed to evaluate the distribution and quantitative assessment of cluster of differentiation 1a (CD1a)-positive Langerhans cells (LCs) in oral lichen planus (OLP), thus to determine the role of LCs pertaining to the changes occurring in OLP.

Materials And Methods: Five cases of normal oral mucosa and 20 cases of OLP were immunostained with CD1a antibody; the positive cells were counted manually in the photomicrographs and statistically analyzed using -test, Mann-Whitney test, and Wilcoxon signed-rank test. Read More

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http://dx.doi.org/10.4103/ijd.IJD_350_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340233PMC
February 2019

Foreign body gingivitis: An uncommon iatrogenic simulant of oral lichenoid mucositis.

JAAD Case Rep 2019 Feb 31;5(2):173-175. Epub 2019 Jan 31.

Department of Dermatology, University of California, San Francisco, California.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357549PMC
February 2019

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus.

Oral Dis 2019 May 27;25(4):1091-1099. Epub 2019 Mar 27.

Department of Oral Medicine, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, China.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. IκB kinase α (IKKα)-regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response. Read More

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http://doi.wiley.com/10.1111/odi.13054
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http://dx.doi.org/10.1111/odi.13054DOI Listing
May 2019
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Serum-based metabolomics characterization of patients with reticular oral lichen planus.

Arch Oral Biol 2019 Mar 30;99:183-189. Epub 2019 Jan 30.

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China. Electronic address:

Objective: Oral lichen planus (OLP) is a chronic inflammatory mucosal lesion and systemic disease. In OLP, reticular type is the most common presentation of the disease. However, little is known about it. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.01.019DOI Listing
March 2019
2 Reads

[Gingival squamous cell carcinoma diagnosed on the occasion of osteonecrosis of the jaw in a patient with chronic GVHD].

Rinsho Ketsueki 2019;60(1):22-27

Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University.

A 44-year-old male was diagnosed with acute myeloid leukemia with a complex karyotype. He underwent bone marrow transplantation using an HLA 6/6 antigen-matched sibling donor, but developed chronic graft-versus-host disease (cGVHD) with skin erythema and oral and esophageal lichen planus changes. Treatment with a combination of prednisolone and cyclosporine was initiated on day 646 after transplantation, but oral symptoms persisted. Read More

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http://dx.doi.org/10.11406/rinketsu.60.22DOI Listing
January 2019
3 Reads

Association of nitric oxide with oral lichen planus.

J Oral Pathol Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: The small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP.

Methods: The focused question being addressed was "Is there an association between nitric oxide and OLP?" PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Read More

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http://dx.doi.org/10.1111/jop.12837DOI Listing
February 2019

The Gingival Oral Lichen Planus: A Periodontal-Oral Medicine Approach.

Case Rep Dent 2019 6;2019:4659134. Epub 2019 Jan 6.

NK Perio & Implants, Perth 6172 Western Australia, Australia.

We present a case of a 77-year-old female who suffered from oral lichen planus (OLP) involving her gingiva and bilateral buccal mucosa for over 6 months. We showed that oral hygiene measures and conventional periodontal treatment and strict maintenance were sufficient to control the gingival involvement of OLP. The mechanism of OLP is complex and not yet fully understood. Read More

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http://dx.doi.org/10.1155/2019/4659134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339732PMC
January 2019