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    The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis.
    J Am Dent Assoc 2017 Jul 13. Epub 2017 Jul 13.
    Background: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants.

    Methods: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. Read More

    Incidence of Oral Lichen Planus in Perimenopausal Women: A Cross-sectional Study in Western Uttar Pradesh Population.
    J Midlife Health 2017 Apr-Jun;8(2):70-74
    Department of Oral Medicine and Radiology, Subharti Dental College, Meerut, Uttar Pradesh, India.
    Background: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Salivary levels of interleukin-8 in oral lichen planus and diabetic patients: A biochemical study.
    Dent Res J (Isfahan) 2017 May-Jun;14(3):209-214
    Dentist, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: This study aimed to assess the salivary levels of interleukin-8 (IL-8) in oral lichen planus (OLP) and diabetes mellitus (DM) patients, and OLP + DM patients in comparison with healthy individuals.

    Materials And Methods: This descriptive cross-sectional study was conducted on 75 patients (30 with OLP, 5 with both OLP and DM, 20 with DM and 20 healthy controls). The salivary levels of IL-8 and fasting blood sugar and 2-h postprandial blood glucose levels were measured in all the subjects. Read More

    Thyroid Autoimmunity and Lichen.
    Front Endocrinol (Lausanne) 2017 27;8:146. Epub 2017 Jun 27.
    Department of Clinical and Experimental Medicine - Endocrinology, University of Messina, Messina, Italy.
    Lichen planus (LP) and lichen sclerosus (LS) are cutaneous-mucous diseases with uncertain epidemiology. Current data, which are likely to be underestimated, suggest a prevalence in the general population of 0.1-4% for cutaneous LP, 1. Read More

    Dental patch testing in patients with undifferentiated oral lichen planus.
    Australas J Dermatol 2017 Jul 11. Epub 2017 Jul 11.
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
    Background/objectives: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP. Read More

    Human β2-defensin in oral lichen planus expresses the degree of inflammation.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):77-87
    Department of Medicine and Surgery, University of Insubria, School of Medicine, Unit of Biochemistry, Varese, Italy.
    Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease, were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. Read More

    Autoantibodies to desmogleins 1 and 3 in patients with lichen planus.
    Arch Dermatol Res 2017 Jul 3. Epub 2017 Jul 3.
    Azad University of Medical Sciences, Tehran, Iran.
    There is controversy about the role of autoantibodies against desmoglein 1 and 3 (Dsg1 and 3) in the pathogenesis of lichen planus (LP); the authors planned this study to determine the presence of circulating levels of these antibodies in patients with different types of oral LP and to compare that with cutaneous LP and healthy controls. The enzyme-linked immunosorbent assay test was performed on serum samples of 24 cases of erosive oral LP, 29 cases of reticular oral LP, 30 cases of cutaneous LP and 30 healthy controls. The severity of oral LP was evaluated by Reticulation, Erosion and Ulceration scoring system. Read More

    Biological functions of melatonin in relation to pathogenesis of oral lichen planus.
    Med Hypotheses 2017 Jul 25;104:40-44. Epub 2017 May 25.
    Department of Community Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.
    Oral lichen planus (OLP) is considered as a chronic inflammatory immune-mediated disease causing oral mucosal damage and ulcerations. Accumulated data support the involvement of cell-mediated immune dysfunction in the development of OLP. However, the connection between neuroendocrine system and oral immune response in OLP patients has never been clarified. Read More

    Linear IgA bullous dermatosis mimicking oral lichen planus.
    Proc (Bayl Univ Med Cent) 2017 Jul;30(3):360-361
    Texas A&M Health Science Center College of Medicine (Shah, Parekh) and Department of Dermatology, Scott & White Memorial Hospital (Shah, Mohr, Parekh), Temple, Texas.
    Linear IgA bullous dermatosis (LABD) is an autoimmune disease characterized by blisters on the skin and mucous membranes. Polycyclic, grouped bullae on cutaneous skin are the most characteristic clinical feature of LABD. Lesions are often indistinguishable from bullous pemphigoid or may resemble dermatitis herpetiformis. Read More

    Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of Oral Lichen Planus.
    Photodiagnosis Photodyn Ther 2017 Jun 29. Epub 2017 Jun 29.
    Department of Oral and Maxillofacial Medicine, Guilan University of Medical Sciences, Rasht, Iran.
    Background: Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease.

    Aim: The present study compared the clinical effects of the photodynamic therapy and dexamethasone mouthwash in the treatment of oral lichen planus lesions. Read More

    Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis.
    BMC Oral Health 2017 Jun 29;17(1):103. Epub 2017 Jun 29.
    Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 20 Noerre Allé, DK-2200, Copenhagen N, Denmark.
    Background: To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.

    Methods: Forty-nine patients (42 women, aged 61.0 ± 10. Read More

    No detection of Merkel cell polyomavirus in oral lichen planus: results of a preliminary study in a French cohort of patients.
    J Med Virol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole -1 rue Irene-Joliot-Curie, 31100 Toulouse, France.
    Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte-mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel Cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients withdifferent forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Read More

    Lichenoid Dysplasia-A Case Report with a Review of Differential Diagnosis.
    J Clin Diagn Res 2017 May 1;11(5):ZD01-ZD02. Epub 2017 May 1.
    Associate Professor and Head, Department of Oral Medicine and Radiology, Christian Dental College, CMC, Ludhiana, Punjab, India.
    Lichenoid Dysplasia (LD) is often regarded as lichen planus with dysplastic features, as it mimics lichen planus clinically and histologically. Although it has been confirmed that these two entities are entirely different with not so similar etiopathogenesis, yet the confusion still exists. The separation between the two is of utmost importance as each of them has their own prognosis and treatment plan. Read More

    Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis of Lichen Planus and Lichenoid Mucositis.
    J Clin Diagn Res 2017 May 1;11(5):ZC84-ZC86. Epub 2017 May 1.
    Postgraduate Student, Department of Oral Pathology, Adhiparasakthi Dental College and Hospital, Chennai, Tamil Nadu, India.
    Introduction: Memory T cells have the ability to survive in a quiescent state for longer periods and are responsible for the rapid responses on subsequent exposure to antigen. Analyzing memory T cells in Oral Lichen planus (OLP) and Lichenoid Mucositis (LM) suggest that these cells may play a role in the immunopathogenic mechanisms.

    Aim: To identify and evaluate Memory T cells in Lichen Planus (LP), Lichenoid Mucositis (LM) and Normal Mucosa (NM) using CD45RO monoclonal antibody immunohistochemically. Read More

    Unilateral Blaschkoian Lichen Planus: A Series of Cases with Review of literature.
    J Clin Diagn Res 2017 May 1;11(5):WR01-WR04. Epub 2017 May 1.
    Junior Resident, Department of Dermatology, Venereology and Leprology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
    A number of congenital and acquired dermatological diseases are known to follow lines of Blaschko. Lichen Planus (LP), commonly acquired inflammatory dermatosis, presents with various morphological forms but Blaschkoian variant is very less published in literature. We herein report a case series of six patients of various age groups with Blaschkoian LP, without any underlying predisposing factors. Read More

    A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma.
    Medicine (Baltimore) 2017 Jun;96(25):e7012
    Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
    Background: In this study, the molecular mechanisms underlying malignant transformation from oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) were examined.

    Methods: High-throughput sequencing of long noncoding RNAs (lncRNAs) and mRNAs of normal subjects and patients with OLP and OSCC was conducted. RNA-seq reads were mapped, lncRNA and mRNA transcripts were assembled, and expression levels were estimated. Read More

    Swiss Dent J 2017 ;127(6):538-539
    Clinique universitaire de chirurgie maxillo-faciale, Hôpital de l’Ile, Hôpital universitaire de Berne, Bern, Switzerland.
    Oral lichen planus is a relatively common T-cell mediated inflammatory disease with potential malignant transformation. It may present itself with pain and oral lesions such as ulcers and Wickham’s striae. Treatment includes topical corticosteroids, preferably Clobetasol, immunosuppressive drugs and retinoids. Read More

    Oral mucous membrane pemphigoid associated with hypothyroidism: A retrospective study and a case report.
    Quintessence Int 2017 ;48(7):569-573
    Objective: The purpose of the study was to evaluate the relationship between mucous membrane pemphigoid and a state of hypothyroidism. The study included analysis of the dental charts of 40 subjects with clinically and histologically confirmed diagnosis of mucous membrane pemphigoid and 35 age- and gender-matched subjects, from the same clinic, with no diagnosis of vesiculo-ulcerative lesions.

    Results: Thirteen subjects from the pemphigoid group (32%) had a hypothyroid condition, compared to four subjects (11%) from the control group (P = . Read More

    Can atrophic erosive oral lichen planus promote cardiovascular diseases? A population-based study.
    Oral Dis 2017 Jun 19. Epub 2017 Jun 19.
    Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Turin, Italy.
    Objectives: Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVDs). The oral manifestations can be divided into white hyperkeratotic lesions (WL) and atrophic erosive lesions (RL). The aim of this report was to compare the presence of CVDs between patients affected by WL or RL, to test the hypothesis that RL are associated with an increased incidence of CVDs. Read More

    Toll-like receptor 2 rs4696480 polymorphism and risk of oral cancer and oral potentially malignant disorder.
    Arch Oral Biol 2017 Jun 6;82:109-114. Epub 2017 Jun 6.
    Oral Medicine & Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain.
    Objectives: The aim of this study was to identify the possible association between TLR polymorphisms and an increased risk of developing head and neck cancer, including oral (OSCC) and laryngeal squamous cell carcinoma (LSCC), and oral potentially malignant disorders, such as oral lichenoid disease (OLD), including oral lichen planus (OLP) and oral lichenoid lesions (OLL).

    Design: This case-control study included 40 OSCC, 35 LSCC, 175 OLD (129 OLP and 46 OLL) patients and 89 healthy controls, all of them from the Basque Country, Spain. Genetic polymorphisms in TLR1, TLR2, TLR4, TLR6, TLR9, and TLR10 were genotyped by TaqMan(®) assays or pyrosequencing. Read More

    Patient-reported outcome measures in oral lichen planus: A comprehensive review of the literature with focus on psychometric properties and interpretability.
    J Oral Pathol Med 2017 Jun 16. Epub 2017 Jun 16.
    UCL Eastman Dental Institute, London, UK.
    Objective: To review the range of patient-reported outcome measures (PROMs) used in clinical studies of patients with oral lichen planus (OLP) and to assess their psychometric properties and interpretability.

    Methods: Literature searches were performed on MEDLINE, EMBASE and Web of Science databases (1990-September 2016) to retrieve relevant studies related to the development, psychometric testing and/or use of PROMs assessing oral symptoms, psychosocial status and quality of life in individuals with OLP. The identified PROMs were then categorised by concept measured and assessed for instrument characteristics and evidence for psychometric properties and interpretability. Read More

    Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis.
    Stem Cells Transl Med 2017 Jun 15. Epub 2017 Jun 15.
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.
    Mesenchymal stem cells (MSCs) have potent immunomodulatory functions and are a promising therapy for immune-mediated inflammatory disorders. We previously demonstrated the efficacy of fresh, autologous, adipose-derived MSCs (ASCs) to treat feline chronic gingivostomatitis (FCGS), a chronic oral mucosal inflammatory disease similar to human oral lichen planus. Here, we investigate the use of fresh allogeneic ASCs for treatment of FCGS in seven cats. Read More

    [The research progress of CO(2) laser in the treatment of oral lichen planus].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Jun;52(6):390-392
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
    Oral lichen planus (OLP) is a common oral mucosal disease. The etiology of OLP is not clear. The treatment of OLP is difficult as some of the OLP patients have little effects to the conventional mucosal treatments. Read More

    A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients.
    Mayo Clin Proc 2017 Jul 7;92(7):1053-1060. Epub 2017 Jun 7.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Objective: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach.

    Patients And Methods: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011.

    Results: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial. Read More

    Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients.
    J Transl Med 2017 Jun 7;15(1):133. Epub 2017 Jun 7.
    Department of Clinical Laboratory, Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, Advance Research Institute of Life Sciences, Nanjing University School of Life Sciences, Nanjing University, Nanjing, 210002, China.
    Background: Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of various diseases, but the clinical relevance of HCMV in OLP has not been thoroughly investigated. Read More

    Clinicopathological Profile and Malignant Transformation in Oral Lichen Planus: A Retrospective Study.
    J Int Soc Prev Community Dent 2017 May-Jun;7(3):116-124. Epub 2017 May 22.
    Department of Oral Pathology and Microbiology, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India.
    Objectives: The aim of this study was to analyze the histopathologically diagnosed cases of oral lichen planus (OLP) in terms of age, gender, clinical variant, site, hyperpigmentation, systemic illness, grade of dysplasia, and associated malignant transformation. This study also intended to do a review of reported cases of OLP with malignant transformation.

    Materials And Methods: One hundred and forty-three cases of histopathologically diagnosed OLP between 2010 and 2016 were retrospectively reviewed. Read More

    Salivary oxidative stress in oral lichen planus treated with triamcinolone mouthrinse.
    Dent Res J (Isfahan) 2017 Mar-Apr;14(2):104-110
    Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
    Background: Total antioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation. Read More

    Use of Topical Corticosteroids in Dermatology: An Evidence-based Approach.
    Indian J Dermatol 2017 May-Jun;62(3):237-250
    Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.
    Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullous pemphigoid. Read More

    Evaluation of Efficacy of 1% Curcuminoids as Local Application in Management of Oral Lichen Planus - Interventional Study.
    J Clin Diagn Res 2017 Apr 1;11(4):ZC89-ZC93. Epub 2017 Apr 1.
    Postgraduate Student, Department of Oral Medicine and Radiology, Amrita School of Dentistry, Kerala, India.
    Introduction: Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity which has been associated with severe burning sensation which in turn affects the quality of life of the patients. Currently, the effective treatment of choice remains the use of corticosteroids. The chronicity and recalcitrant nature of the disease demand the long term use of these drugs with ensuing adverse effects. Read More

    Oral mucosal lesions in teenagers: a cross-sectional study.
    Ital J Pediatr 2017 May 31;43(1):50. Epub 2017 May 31.
    Dental School, Pediatric Dentistry Department, University of Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.
    Background: Adolescence is a period of transition to adulthood. Little is known about oral mucosal lesions (OMLs) in teenagers, in which the emergence of new habits, unfamiliar to children, could affect the type of lesions. The aim of this study was to evaluate the distribution of oral mucosal lesions (OMLs) in a wide sample of adolescents. Read More

    Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids.
    Open Dent J 2017 31;11:155-163. Epub 2017 Mar 31.
    School of Dentistry, The University of Western Australia, Perth, Western Australia.
    Background: Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness. Read More

    Survivin in autoimmune diseases.
    Autoimmun Rev 2017 May 28. Epub 2017 May 28.
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:
    Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Read More

    High percentage of oral lichen planus and lichenoid lesion in oral squamous cell carcinomas.
    Acta Odontol Scand 2017 Aug 31;75(6):442-445. Epub 2017 May 31.
    a Department of Oral and Maxillofacial Diseases and Surgery , Head and Neck Center, Helsinki University Hospital , Helsinki , Finland.
    Objective: Oral lichen planus (OLP) and lichenoid lesions (OLL) are regarded as precursor lesions of oral squamous cell carcinoma (OSCC) with potential for malignant transformation. This potential is not clear due to difficulties in diagnosis of OLP and OLL. Our aim was therefore to evaluate previously identified OLP and OLL as precursor lesions in OSCC and to identify cancer related etiological factors such as smoking and alcohol consumption. Read More

    Isolated Actinic Lichen Planus of the Lower Lip.
    Case Rep Dermatol 2017 Jan-Apr;9(1):131-134. Epub 2017 Apr 27.
    National University Hospital, Singapore, Singapore.
    Oral lichen planus (LP) is a common manifestation in patients with LP; however, isolated lip LP is rare and may mimic other conditions such as lichenoid drug eruptions, actinic cheilitis, and early carcinoma in situ in the absence of typical skin lesions. Actinic lichen planus (ALP) is a variant of LP occurring on light-exposed areas in patients with dark skin. We report the case of a Chinese female with isolated ALP of the lower lip, mimicking herpes simplex infection at presentation. Read More

    The cellular character of liquefaction degeneration in oral lichen planus and the role of interferon gamma.
    J Oral Pathol Med 2017 May 29. Epub 2017 May 29.
    Department of Oral medicine, the School of Stomatology, the Fourth Military Medical University, Xi'an, Shaanxi Province, China.
    Background: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, and liquefaction degeneration in the basal keratinocytes is one of the specific histological changes. However, the understanding of liquefaction degeneration is still very limited, and how does it affect the prognosis of LP is largely unknown. Therefore, the objective of this study was to clarify the intrinsic change behind the liquefaction degeneration in lichen planus and to evaluate the effect of the OLP-typical cytokine, IFN-γ, on these changes. Read More

    Caveolin-1 expression in oral lichen planus, dysplastic lesions and squamous cell carcinoma.
    Pathol Res Pract 2017 Jul 9;213(7):809-814. Epub 2017 Mar 9.
    School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
    Caveolin-1(Cav-1), the main part of caveolae structure, is supposed to play a role in pathogenesis of many human tumors. Since oral lichen planus (OLP) is considered as a potential premalignant disease, this study evaluated Cav-1 expression in OLP in comparison with benign hyperkeratosis, dysplastic epithelium and oral squamous cell carcinoma (OSCC), to investigate its possible role in pathogenesis and malignant transformation of OLP. In this cross-sectional retrospective study, immunohistochemical expression of Cav-1 in the epithelial component and stroma was evaluated in 81 samples, including 12 cases of hyperkeratosis, 24 OLP, 22 epithelial dysplasia, and 23 OSCC samples. Read More

    Oral lichenoid lesions of the upper lip.
    J Dermatol Case Rep 2017 Mar 31;11(1):16-19. Epub 2017 Mar 31.
    Dental Clinic, Penteli Children's General Hospital, Athens, Greece.
    Background: Oral lichen planus is a chronic inflammatory disease of unknown etiology. It is characterized by notable heterogeneity in clinical presentation and behavior.

    Main Observations: We describe 3 patients with lichenoid lesions of the upper lip and upper anterior gingiva. Read More

    Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus.
    An Bras Dermatol 2017 Mar-Apr;92(2):168-171
    Dental Research Center, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences - Tehran, Iran.
    Background:: Oral lichen planus is a potentially malignant disorder. One of the malignant transformation markers is cancer stem cells. One of the proposed marker for the detection of cancer stem cells's in head and neck cancer is aldehyde dehydrogenase. Read More

    Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review.
    Lasers Med Sci 2017 May 24. Epub 2017 May 24.
    Department of Oral Medicine and Diagnostic Sciences, Al-Farabi Colleges, Riyadh, Saudi Arabia.
    Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology and indefinite cure. This systematic review assessed the efficacy of low-level laser therapy in the treatment of symptomatic OLP. Electronic databases (PubMed, Scopus, and Web of Science) were searched from date of inception till and including December 2016, using various combinations of the following keywords: oral lichen planus, laser therapy, low-level laser therapy, and phototherapy. Read More

    Identifying the association between interleukin-6 and lichen planus: A meta-analysis.
    Biomed Rep 2017 May 7;6(5):571-575. Epub 2017 Apr 7.
    Department of Pediatric Dentistry, Jinan Stomatological Hospital, Jinan, Shandong 250002, P.R. China.
    Numerous studies have examined the association between interleukin-6 and the pathogenesis of lichen planus (LP)/oral LP (OLP) in various populations; however, there is a lack of systematic analysis. The aim of the present study was to assess this association more precisely, thus a meta-analysis was performed. Case-control studies, which were published up to December 2015, were obtained from PubMed, Embase and the China National Knowledge Infrastructure databases. Read More

    Quantification of l-carvone in toothpastes available on the Swedish market.
    Contact Dermatitis 2017 May 19. Epub 2017 May 19.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. Read More

    A panel of microRNAs can be used to determine oral squamous cell carcinoma.
    J Oral Pathol Med 2017 May 17. Epub 2017 May 17.
    Melbourne Dental School, The University of Melbourne, Melbourne, Vic., Australia.
    Background: Subjective histopathology is currently used to diagnose oral squamous cell carcinoma (OSCC). We tested if abundances of a panel of microRNA could be an objective OSCC indicator.

    Method: Literature review enabled identification of 10 microRNAs associated with oral and head and neck malignancies. Read More

    Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression.
    Inflammopharmacology 2017 May 13. Epub 2017 May 13.
    Hematology and Blood Banking Department, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. Read More

    Probiotics: A non-conventional therapy for oral lichen planus.
    Arch Oral Biol 2017 Sep 26;81:90-96. Epub 2017 Apr 26.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, PR China. Electronic address:
    Oral lichen planus (OLP) is a common T-cell mediated chronic inflammatory disease. Although the etiology is still unclear, present studies suggest that the composition of the oral microbiota and psychological problems are implicated in the etiology of OLP. The pathogenesis of OLP includes mainly antigen-specific and non-specific mechanisms. Read More

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