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    VEGFR-3 Expression in Oral Lichen Planus
    Asian Pac J Cancer Prev 2017 02 1;18(2):381-384. Epub 2017 Feb 1.
    Oral and Maxillofacial Pathology Department, Dental Faculty, Babol University of Medical Sciences, Babol, Iran.
    Background and objective: Given the postulated the role of inflammation and possible contribution of lymphangiogenesis in oral lichen planus, this study aimed to assess any associated presence of VEGFR-3. Material and Methods: This cross-sectional study was performed on 52 formalin fixed and paraffin embedded blocks of oral lichen planus (pathological diagnosis based on Modified WHO criteria), comprising 25 of erosive and 27 of reticular type, along with 60 samples of normal mucosa (with minimal inflammation from clinical and histopathological aspects) obtained at crown lengthening surgery. Four micron sections were cut from paraffin blocks and stained with H and E for confirmation of diagnosis and by immunohistochemistry with primary antibodies against VEGFR-3. Read More

    Immunopathogenic Oral Diseases: 
An Overview Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017 Mar 20. Epub 2017 Mar 20.
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Subgingival Microbiota in Caucasian Patients With Desquamative Gingivitis: A Cross-Sectional Study.
    J Periodontol 2017 Mar 17:1-14. Epub 2017 Mar 17.
    Department of Surgical Sciences, CIR - Dental School, University of Turin, Turin, Italy.
    Background: The presence of epithelial desquamation, erythema, and erosions on the gingival tissue is usually described in literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatological disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study was to investigate the prevalence of 11 periodonto-pathogenic microorganisms in DG cases and to compare it with microbiologic status of individuals affected by plaque-induced gingivitis (GI). Read More

    Association between polymorphisms in interleukins and oral lichen planus: A meta-analysis.
    Medicine (Baltimore) 2017 Mar;96(11):e6314
    Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
    Background: More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene polymorphisms with the OLP risk. Read More

    Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue.
    J Oral Pathol Med 2017 Mar 10. Epub 2017 Mar 10.
    Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, 2-1-1 Nishitokuta Yahaba Shiwa-gun, Iwate, 028-3694, Japan.
    Background: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Read More

    A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.
    Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1070. Epub 2016 Dec 23.
    Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
    Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Read More

    Free palatal mucosal graft for treatment of erosive oral lichen planus.
    J Formos Med Assoc 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:

    Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus.
    PLoS One 2017 9;12(3):e0173017. Epub 2017 Mar 9.
    Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
    Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammation. Read More

    Gene expression of miRNA-138 and cyclin D1 in oral lichen planus.
    Clin Oral Investig 2017 Mar 8. Epub 2017 Mar 8.
    Department of Medical Biochemistry& Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt.
    Objectives: This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis.

    Methods: Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression. Read More

    Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing.
    Oncol Rep 2017 Apr 2;37(4):2355-2365. Epub 2017 Mar 2.
    Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
    Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the differently expressed genes (DEGs) in OLP vs. Read More

    [Frontal fibrosing alopecia: A prospective study of 20 cases].
    Ann Dermatol Venereol 2017 Feb 28. Epub 2017 Feb 28.
    Centre d'anatomopathologie Hassane, Rabat, Maroc.
    Background: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment.

    Patients And Methods: This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco. Read More

    Oral lichen planus in childhood: a case series.
    Int J Dermatol 2017 Mar 3. Epub 2017 Mar 3.
    Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.
    Background: Although the exact incidence of pediatric oral lichen planus (OLP) is unknown, the oral mucosa seems to be less commonly involved, and the clinical presentation is often atypical. The aim of the study is to present a case series of OLP in childhood.

    Methods: From our database, we retrospectively selected and analyzed the clinical data of OLP patients under the age of 18 where the diagnosis had been confirmed by histopathological analysis. Read More

    Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease.
    PLoS One 2017 2;12(3):e0172821. Epub 2017 Mar 2.
    University College London, UCL Eastman Dental Institute, London, United Kingdom.
    The IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 play a key role in many inflammatory conditions, particularly those mediated by T cells. Therefore, the production of these chemokines in peripheral tissues could be instrumental in the pathophysiology of tissue-specific immunological diseases such as oral lichen planus (OLP). In the present study, we assessed the production of keratinocyte-derived CXCL9/10/11 under basal and inflammatory conditions and investigated whether these chemokines were involved in the pathogenesis of OLP. Read More

    Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era.
    J Eur Acad Dermatol Venereol 2017 Mar 2. Epub 2017 Mar 2.
    Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY.
    New all-oral direct acting antivirals (DAA) have changed the hepatitis C virus (HCV) treatment landscape. Given that dermatologists frequently encounter HCV-infected patients, knowledge of the current treatment options and their utility in treating HCV-associated dermatologic disorders is important. In addition to highlighting the new treatment options, we review four classically HCV-associated dermatologic disorders - mixed cryoglobulinemia (MC), lichen planus (LP), porphyria cutanea tarda (PCT), and necrolytic acral erythema (NAE) - and examine the role for all-oral direct acting antiviral (DAA) regimens in their treatment. Read More

    Identification of potential therapeutic target genes, key miRNAs and mechanisms in oral lichen planus by bioinformatics analysis.
    Arch Oral Biol 2017 Feb 12;78:122-128. Epub 2017 Feb 12.
    Department of Reconstruction Surgery, Dalian Hospital of Stomatology, No. 935 Changjiang Rd, Shahekou District, Dalian, Liaoning, 116021, China. Electronic address:
    The study aimed to identify the potential target genes and key miRNAs as well as to explore the underlying mechanisms in the pathogenesis of oral lichen planus (OLP) by bioinformatics analysis. The microarray data of GSE38617 were downloaded from Gene Expression Omnibus (GEO) database. A total of 7 OLP and 7 normal samples were used to identify the differentially expressed genes (DEGs) and miRNAs. Read More

    Experimental Study on 1,25(OH)2 D3 Amelioration of Oral Lichen Planus through Regulating NF-κB Signaling Pathway.
    Oral Dis 2017 Feb 23. Epub 2017 Feb 23.
    Department of Stomatology of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
    Objective: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it.

    Methods: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR. Read More

    Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus.
    Clin Chim Acta 2017 Feb 16;468:46-50. Epub 2017 Feb 16.
    School of Stomatology, Harbin Medical University, Harbin 151000, PR China.
    Background: Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    [Analysis of type C behavior in patients with oral lichen planus].
    Beijing Da Xue Xue Bao 2017 Feb;49(1):120-124
    Department of Oral Medicine,Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To assess type C behavior in patients with oral lichen planus (OLP) in order to provide basis for clinical prevention, treatment and psychological intervention of OLP.

    Methods: Type C behavior scale was used on 85 OLP patients and 85 control patients, who were in accordance with the inclusion criteria, in order to investigate their type C behavior. The scale included 9 items: anxiety, depression, anger, anger toward inside (anger-in), anger toward outside (anger-out), reasoning, domination, optimism, and social support. Read More

    Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus.
    Oral Dis 2017 Feb 15. Epub 2017 Feb 15.
    School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
    Objective: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control.

    Subjects And Methods: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. Read More

    Investigating the level of salivary endothelin-1 in premalignant and malignant lesions.
    Spec Care Dentist 2017 Feb 15. Epub 2017 Feb 15.
    Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
    Purpose: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions.

    Materials And Methods: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. Read More

    Salivary oxidative status in patients with oral lichen planus.
    J Physiol Pharmacol 2016 Dec;67(6):885-894
    Department of Periodontology and Oral Medicine, Jagiellonian University Medical College, Cracow, Poland.
    Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. Read More

    Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.
    Arch Oral Biol 2017 Feb 6;78:13-19. Epub 2017 Feb 6.
    Research Group of Chronic Inflammatory Oral Diseases and Systemic Diseases Associated with Oral Health, Khon Kaen University, Khon Kaen, Thailand; Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand. Electronic address:
    Objective: The existence of extra-pineal melatonin has been observed in various tissues. No prior studies of melatonin in human oral mucosal tissue under the condition of chronic inflammation have been reported. The aim of this study was to investigate the presence of melatonin in oral mucosal tissue of patients with oral lichen planus (OLP) which was considered as a chronic inflammatory immune-mediated disease causing oral mucosal damage and ulcerations. Read More

    Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?
    J Oral Pathol Med 2017 Feb 10. Epub 2017 Feb 10.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunofluorescent microscopy are essential for definitive diagnosis. Read More

    Most Frequent Oral Lesions in Patients with Type 2 Diabetes Mellitus.
    J Contemp Dent Pract 2017 Feb 1;18(2):107-111. Epub 2017 Feb 1.
    Department of Dentistry, Federal University of Sergipe Lagarto, Sergipe, Brazil.
    Aim: Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease.

    Materials And Methods: This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF. Read More

    Topical tacrolimus, triamcinolone acetonide and placebo in oral lichen planus: A pilot randomized controlled trial.
    Oral Dis 2017 Feb 6. Epub 2017 Feb 6.
    Institute of Dentistry, University of Oulu, Finland.
    Objective: To carry out a double-blind RCT to compare the effectiveness of topical tacrolimus (TAC), triamcinolone acetonide (TRI) and placebo (PLA) in symptomatic OLP.

    Subjects And Methods: A clinical score (CS, range 0-130) was developed to measure the clinical signs and symptoms of OLP. Twenty-seven OLP patients with a CS of ≥ 20 were randomly allocated to receive 0. Read More

    Comparison of B-Cell Activating Factor Expression in Neutrophils in Patients with Potentially Malignant Disorders and Patients with Cancer in the Same Site.
    Clin Lab 2016 Aug;62(8):1507-1514
    Background: B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC), suggesting a tumor-promoting activity of those cells. Taking into consideration that numerous OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs), involving e. Read More

    Letter to the Editor: Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL?
    Med Oral Patol Oral Cir Bucal 2017 Mar 1;22(2):e142-e143. Epub 2017 Mar 1.
    Faculdade de Odontologia de Piracicaba - UNICAMP, Departamento de Diagnóstico Oral - Semiologia, Av. Limeira, 901 CEP 13.414-903, Piracicaba - São Paulo - Brasil,

    The use of topical corticosteroides in the treatment of oral lichen planus in Spain: A national survey.
    Med Oral Patol Oral Cir Bucal 2017 Feb 4. Epub 2017 Feb 4.
    Eduardo Anitua Foundation, C/ Jose Maria Cagigal 19, 01007 Vitoria, Spain
    Background: Explore the treatment of oral lichen planus with topical corticosteroids by the healthcare professionals in Spain.

    Material And Methods: A questionnaire targeted health professionals who treat OLP, in particular maxillofacial surgeons, dermatologist and dentist. The dissemination of the questionnaires was conducted through professional associations and dental and medical societies. Read More

    Autoimmune Disease Manifestations in the Oral Cavity.
    Surg Pathol Clin 2017 Mar 28;10(1):57-88. Epub 2016 Dec 28.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA.
    Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns. Read More

    Swiss Dent J 2017 ;127(1):27-37
    Poliklinik für Zahnärztliche Prothetik und Werkstoffkunde, Universitätsklinikum Leipzig, Leipzig, Germany.
    Allergen-triggered lichenoid oral mucosa lesions may occur both in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Clinically, OLP and OLL are difficult to distinguish from each other. An OLP should be checked by histological examination. Read More

    Increased circulating CXCR5(+) CD4(+) T follicular helper-like cells in oral lichen planus.
    J Oral Pathol Med 2017 Jan 25. Epub 2017 Jan 25.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
    Background: CD4(+) T-helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T-helper cells, have been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated. Read More

    A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series.
    Photodiagnosis Photodyn Ther 2017 Jan 21. Epub 2017 Jan 21.
    Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269 Białystok, Poland; Dental Practice, ul. Waszyngtona 1/34, 15-269 Białystok, Poland.
    Background: Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of EOLP. Read More

    Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis.
    Vet Pathol 2017 Jan 1:300985816688754. Epub 2017 Jan 1.
    3 Department of Pathology, Microbiology and Immunology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA.
    Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Read More

    Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products.
    Clin Oral Investig 2017 Jan 13. Epub 2017 Jan 13.
    Section for Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Medical and Health Sciences, University of Copenhagen, 20 Noerre Allé, 2200, Copenhagen N, DK, Denmark.
    Objective: Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact allergies to dental materials and oral hygiene products in these patients.

    Methods: Forty-nine patients (7 men, 42 women) aged 31 to 77 years (61 ± 10. Read More

    Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
    Medicine (Baltimore) 2017 Jan;96(2):e5075
    aDepartment of Dental Surgery bDepartment of Endocrinology, Brest University Hospital, Brest cDepartment of Dermatology, Quimper Hospital, Quimper dDepartment of Oral Surgery, Brest University Hospital, Brest, France.
    Background: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Read More

    Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study.
    Acta Inform Med 2016 Dec;24(6):390-393
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.

    Methods: In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Read More

    Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients.
    Braz Oral Res 2017 Jan 5;31:e10. Epub 2017 Jan 5.
    Isfahan University of Medical Sciences, Department of Oral and Maxillofacial Medicine, Isfahan, Iran.
    This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. Read More

    Genome-wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis C Virus Infection.
    Clin Gastroenterol Hepatol 2017 Jan 5. Epub 2017 Jan 5.
    Department of Virology, Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
    Background & Aims: There is a close relationship between hepatitis C virus (HCV) infection and lichen planus, a chronic inflammatory muco-cutaneous disease. We performed a genome-wide association study (GWAS) to identify genetic variants associated with HCV-related lichen planus.

    Methods: We conducted a GWAS of 261 patients with HCV infection treated at a tertiary medical center in Japan from October 2007 through January 2013; 71 had lichen planus and 190 had normal oral mucosa. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    Interventions for the management of oral lichen planus: a review of the conventional and novel therapies.
    Oral Dis 2017 Jan 5. Epub 2017 Jan 5.
    Department of Oral Medicine & Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Objective: This narrative review focuses on the rationale and role of conventional and newer therapies in the management of oral lichen planus (OLP) with emphasis on randomized controlled trials (RCTs) reported over two decades.

    Materials And Methods: Literature search was conducted to identify RCTs for the management of OLP from 1 January 1995 to 31 December 2015; Medline and Cochrane databases complemented with manual search were used. Primary outcome as resolution of pain was evaluated with the analysis of clinical resolution of erythema and ulceration as secondary outcome. Read More

    Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma.
    Mediators Inflamm 2016 8;2016:5715719. Epub 2016 Dec 8.
    Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
    Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions-oral leukoplakia (OLK) and oral lichen planus (OLP)-to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. Read More

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