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    1 OF 82

    Comparative study of β-catenin and CD44 immunoexpression in oral lichen planus and squamous cell carcinoma.
    Int J Dermatol 2018 Apr 24. Epub 2018 Apr 24.
    Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
    Background: Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC).

    Methods: β-Catenin and CD44 expression were evaluated in 15 patients with epithelial hyperplasia (group A), 20 OLP (group B), and 20 OSCC (group C) by immunohistochemistry. Read More

    Association between oral lichen planus and Epstein-Barr virus in Iranian patients.
    J Res Med Sci 2018 27;23:24. Epub 2018 Mar 27.
    Royan Institute for Biotechnology, Isfahan, Iran.
    Background: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein-Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. Read More

    Grinspan's Syndrome: A Rare Case with Malignant Transformation.
    Case Rep Otolaryngol 2018 4;2018:9427650. Epub 2018 Mar 4.
    Department of Otolaryngology, Istanbul Medeniyet University Medical Faculty, Goztepe Training and Research Hospital, Istanbul, Turkey.
    Aim: Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan's syndrome in 1966. Read More

    Oral Lichen planus.
    J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):391-395
    Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
    Oral Lichen planus (OLP) is the most frequent mucosal localization of Lichen planus, affecting about 1-2% of the population. It is associated with skin lesions in 60-70% of cases, while occurring as the only manifestations in 15-25% of patients. Six clinical forms of OLP are identified: reticular (the most common), plaque, papular, atrophic, vesicles/bullous and erosive. Read More

    Immunoexpression of cytokeratin-19 in the oral lichen planus and related oral squamous cell carcinoma.
    Ann Stomatol (Roma) 2017 Sep-Dec;8(3):104-109. Epub 2018 Mar 8.
    Maxillo-Facial and Dental Unit (Head Prof. AB Giannì) Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico Milan, Italy - Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy.
    Aims: Cytokeratin 19 (CK-19) is an epithelium-specific intermediate filament protein that has been investigated in oral lichen planus (OLP) lesions but has not been compared with the expression of CK-19 in the OLP-related oral squamous cell carcinoma (OSCC). The aim of the present study has been to objectively compare the immunohistochemical expression of the CK-19 in OLP lesions and subsequent OSCC lesions that developed over time, to evaluate the change of the staining pattern among OLP and the grades of differentiation in OSCC.

    Methods: Thirty-six formalin-fixed tissues of 18 OLP patients (18 samples from OLP lesion and 18 samples from OLP-related OSCC lesion) were included. Read More

    Markers of Oral Lichen Planus Malignant Transformation.
    Dis Markers 2018 26;2018:1959506. Epub 2018 Feb 26.
    "Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.
    Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Read More

    Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions.
    Med Oral Patol Oral Cir Bucal 2018 Apr 22. Epub 2018 Apr 22.
    Universidade Federal de Uberlandia Faculdade de Odontologia Área de Patologia. Av. Para, 1720 Campus Umuarama. CEP: 38405-320 Uberlandia - MG Brazil
    Background: Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic pathways and the anti-oxidative response, could serve as a differential diagnostic for OLP and OLL. Read More

    Desquamative gingivitis: Clinical findings and diseases.
    J Am Acad Dermatol 2018 May;78(5):839-848
    Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Dermatology, Weill Cornell Medical College, New York, New York.
    Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Read More

    Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end-products and toll-like receptor-4 in the immunopathology of oral lichen planus: a potential drug target?
    Eur J Oral Sci 2018 Apr 20. Epub 2018 Apr 20.
    Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
    High mobility group box 1 (HMGB1) is an extremely conserved DNA-binding protein that stabilizes nucleosomes and facilitates gene transcription in mammalian cells. When released extracellularly, HMGB1 becomes an alarmin that can mediate systemic diseases. High mobility group box 1 signals via two main receptors: receptor for advanced glycation end-products (RAGE) and toll-like receptor-4 (TLR4). Read More

    Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: review from a dermatologic perspective.
    Photodiagnosis Photodyn Ther 2018 Apr 15. Epub 2018 Apr 15.
    University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy.
    Photodynamic Therapy is a procedure based on the interaction between a Photo Sensitizer, a light source with a specific wavelength and oxygen. Aim of this Review is to provide a brief and updated analysis of scientific reports of the use of PDT with topical PS in the management of oncological, infectious, and inflammatory disorders involving mucosal and semimucosal areas, with a specific focus on diseases of dermatologic interest. Read More

    Management update of potentially premalignant oral epithelial lesions.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 23. Epub 2018 Mar 23.
    Department of Oral and Maxillofacial Surgery, North Memorial Medical Center, Minneapolis, MN, USA. Electronic address:
    The term oral potentially malignant disorders, proposed at the World Health Organization workshop in 2005, has now been renamed potentially premalignant oral epithelial lesions (PPOELs). It is important to differentiate among PPOELs, which is a broad term to define a wide variety of clinical lesions, and oral epithelial dysplasia, which should be reserved specifically for lesions with biopsy-proven foci of dysplasia. PPOELs encompass lesions that include leukoplakia, erythroplakia, erythroleukoplakia, lichen planus, and oral submucous fibrosis. Read More

    Study of virulence factor of Candida species in oral lesions and its association with potentially malignant and malignant lesions.
    Arch Oral Biol 2018 Feb 19;91:35-41. Epub 2018 Feb 19.
    Dpto. de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina.
    Objective: The aim of this study was to explore the association between malignant and premalignant lesions and the virulence factor profile of Candida spp. recovered from different oral lesions.

    Design: Candida spp. Read More

    Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics.
    J Biomed Opt 2018 Apr;23(4):1-8
    National Research Tomsk State Univ., Russia.
    The ability to diagnose oral lichen planus (OLP) based on saliva analysis using THz time-domain spectroscopy and chemometrics is discussed. The study involved 30 patients (2 male and 28 female) with OLP. This group consisted of two subgroups with the erosive form of OLP (n  =  15) and with the reticular and papular forms of OLP (n  =  15). Read More

    Association between TNFα - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis.
    J Appl Oral Sci 2018 Apr 5;26:e20170184. Epub 2018 Apr 5.
    University of Pittsburgh, School of Dental Medicine, Department of Oral Biology, Pittsburgh, PA, U.S.A.
    Objectives: To determine whether Tumor Necrosis Factor alpha (TNFα) -308 G/A polymorphism is associated with oral lichen planus (OLP).

    Material And Methods: A systematic electronic search of the literature was conducted to identify all published studies on the association between TNFα -308 G/A polymorphism and OLP. All case-control studies evaluating the TNFα -308 G/A polymorphisms in OLP were selected. Read More

    Chronic oral lichenoid erosions revealing haematological malignancies.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Dermatology Department, Saint-Louis Hospital, Paris, France.
    Lichen planus is a chronic inflammatory disease of the skin and oral mucosa involving CD8+ T cells (1). Paraneoplastic pemphigus (PNP) is an autoimmune blistering skin disease associated with solid cancer or haematological malignancies (HM). We report 4 patients with long term oral lichenoid erosions leading to the diagnosis of PNP associated with HM. Read More

    Expression of IL33 and IL35 in oral lichen planus.
    Arch Dermatol Res 2018 Apr 9. Epub 2018 Apr 9.
    Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, 310 Great King Street, Dunedin, 9054, New Zealand.
    Oral lichen planus (OLP) is a complex immunological disorder, mediated in part by the release of cytokines by activated T-cells. Recently, the role of novel cytokines including IL33 and IL35 has been described in various chronic inflammatory diseases. IL33, a member of the IL-1 superfamily of cytokines, functions as an 'alarmin' released after cell necrosis to alert the immune system to tissue damage or stress. Read More

    Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy.
    F1000Res 2018 6;7:284. Epub 2018 Mar 6.
    Department of Dermatology, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
    Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. Read More

    Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:
    Objective: The aim of this study was to measure T helper (Th) 1/Th2-related cytokine expression in saliva from patients with oral lichen planus (OLP), compared with healthy controls (HC group) and controls with recurrent aphthous ulcers (RAU group).

    Study Design: Saliva was collected from 41 patients with OLP, 14 HCs, and 14 controls with RAU for Th1/Th2-related cytokines analysis with cytometric bead array. Disease activity in OLP was recorded by reticulation/keratosis, erythema, and ulceration scores. Read More

    To Evaluate the Efficacy of Topical Propolis in the Management of Symptomatic Oral Lichen Planus: A Randomized Controlled Trial.
    Contemp Clin Dent 2018 Jan-Mar;9(1):65-71
    Department of Pharmaceutics JSS College of Pharmacy, Mysore, Karnataka, India.
    Introduction: Lichen planus (LP) is a chronic inflammatory, autoimmune, mucocutaneous disease of unknown etiology. The first line of treatment for oral LP (OLP) has been corticosteroids, but because of their adverse effects, alternative therapeutic approaches are being carried out, of which the recent natural alternative is propolis.

    Aim: This study aims to evaluate the efficacy of topical propolis in the management of OLP. Read More

    Association of Matrix Metalloproteinase-7 Genotypes to the Risk of Oral Cancer in Taiwan.
    Anticancer Res 2018 04;38(4):2087-2092
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
    Background/aim: Matrix metalloproteinases (MMPs) play a critical role in inflammation and carcinogenesis, and the expression of mRNA MMP7 in oral squamous cell carcinoma tissues was higher than in the oral lichen planus or normal oral mucosa. However, the genotypic role of MMP7 has never been examined in oral cancer. Therefore, in the current study we aimed to examine the contribution of genotypic variants in the promoter region of MMP7 (A-181G and C-153T) to oral cancer risk in Taiwan. Read More

    Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions.
    Autoimmune Dis 2018 17;2018:7936564. Epub 2018 Jan 17.
    Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute (Deemed to Be University), Chennai, India.
    Introduction: Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Read More

    Efficacy of oral sirolimus as salvage therapy in refractory lichen planus associated with immune deficiency.
    Br J Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    Dermatology Department, AP-HP Hôpital Saint-Louis, Paris.
    Lichen planus (LP) remains often difficult-to-treat in its chronic, severe and erosive forms, requiring use of immunomodulatory (acitretin, PUVA, and extracorporeal photochemotherapy (EPC)) or off label immunosuppressive strategies (cyclosporine, azathioprine). However, the pathogenic role of an HPV-specific T-cell response in chronic LP, and the increased risk of neoplasia, especially in its severe mucosal forms, both support the use of T-cell-targeting immunosuppressants with antineoplastic attributes, such as mammalian target of rapamycin (mTOR) inhibitors . This article is protected by copyright. Read More

    Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients.
    Oral Dis 2018 Mar 23. Epub 2018 Mar 23.
    Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
    Some patients with oral lichen planus (OLP) experience recurrent oral candidiasis(OC). Probiotic bacteria have shown to reduce the oral Candida count in vivo.

    Objective: To study if probiotic intervention reduces recurrent OC in patients with OLP. Read More

    Impact of oral potentially malignant disorders on quality of life: a systematic review.
    Future Oncol 2018 Apr 21;14(10):995-1010. Epub 2018 Mar 21.
    Department of Maxillofacial Surgery & Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
    Although oral potentially malignant disorders (OPMDs) are relatively common and potentially debilitating, literature on quality of life (QoL) in these patients is scanty. The purpose of this paper is to systematically review the literature on QoL in patients with OPMDs. A total of 210 titles were retrieved from electronic and manual databases searched from 1960 until September 2017. Read More

    Salivary Cortisol and Salivary Flow Rate in Clinical Types of Oral Lichen Planus.
    Skinmed 2018 1;16(1):19-22. Epub 2018 Feb 1.
    Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;
    Patients with oral lichen planus (OLP) may develop immune sialadenitis that causes a dry mouth. The role of cortisol in autoimmune diseases is well known; yet studies on this subject are controversial. In this study, the salivary flow rate and salivary cortisol level were compared among subtypes of OLP. Read More

    Putative salivary protein biomarkers for the diagnosis of oral lichen planus: a case-control study.
    BMC Oral Health 2018 03 13;18(1):42. Epub 2018 Mar 13.
    Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, 6 Yodhi St., Rajthewee, Bangkok, 10400, Thailand.
    Background: Salivary protein biomarkers for screening and diagnosis of oral lichen planus (OLP) are not well-defined. The objective of this study was to identify putative protein biomarkers for OLP using proteomic approaches.

    Methods: Pooled unstimulated whole saliva was collected from five OLP patients and five healthy control participants. Read More

    Palmoplantar Lesions of Lichen Planus.
    Indian J Dermatol 2018 Jan-Feb;63(1):57-61
    Department of Dermatology, STD and Leprosy, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
    Introduction: Palmoplantar lesions of lichen planus (LP) are uncommon and may not always have classical clinical features of LP. A variety of morphological types has been described in literature.

    Aim And Objectives: The aim was to study and classify the clinical variants into distinct easily recognisable categories for quick recognition and early treatment initiation. Read More

    Medication use and medical history of 155 patients with oral lichenoid lesions: a retrospective study.
    Gen Dent 2018 Mar-Apr;66(2):40-45
    Several medications have been reported as possible etiologic factors for oral lichen planus (OLP) and oral lichenoid lesions (OLLs). This study investigated the medication profile and medical history of patients with biopsy-proven OLP or OLLs, also classified by the clinically nonspecific term oral lichenoid mucositis (OLM), in a busy oral medicine clinic. The University of Florida College of Dentistry records from 2009 to 2014 were searched retrospectively for all patients with a biopsy-proven diagnosis of OLP, OLLs, or OLM. Read More

    Comparison of the Effects of Curcumin Mucoadhesive Paste and Local Corticosteroid on the Treatment of Erosive Oral Lichen Planus Lesions.
    J Natl Med Assoc 2018 Feb 11;110(1):92-97. Epub 2017 May 11.
    Department of Oral Medicine, Gorgan University Of Medical Science, Faculty of Dentistry, Gorgan, Iran.
    Introduction: Lichen planus is a prevalent chronic mucocutaneous condition, whose exact pathogenesis has not been elucidated yet and its standard treatment at present involves the use of local corticosteroids. Curcumin is a colored material extracted from Curcuma longa plant species and is used as an appetizer and for medical purposes. It has anti-inflammatory, antioxidative and anti-cancerous properties. Read More

    Short dental implants in patients with oral lichen planus: a long-term follow-up.
    Br J Oral Maxillofac Surg 2018 Apr 2;56(3):216-220. Epub 2018 Mar 2.
    University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain; BTI Biotechnology Institute, Vitoria, Spain.
    Oral lichen planus is associated with the Koebner phenomenon, and trauma may exacerbate oral lesions. Short dental implants, as alternatives to bony augmentation, would reduce the number of interventions and their morbidity. However, we know of no studies that have analysed the long-term outcomes of short implants in patients with oral lichen planus. Read More

    A mechanistic linkage between oral lichen planus and autoimmune thyroid disease.
    Oral Dis 2018 Mar 2. Epub 2018 Mar 2.
    Department of Oral Medicine and Oral Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objective: To determine the levels of antithyroid antibodies and thyroid hormones in the sera of patients with oral lichen planus (OLP), and to quantify the expression of thyroid proteins in OLP lesions.

    Subjects And Methods: Venous blood samples were drawn from 110 patients with OLP who had no history of thyroid disease or levothyroxine supplementation (OLP+/LT -). A random population sample of 657 healthy subjects was used as the control group. Read More

    Therapeutics for Adult Nail Psoriasis and Nail Lichen Planus: A Guide for Clinicians.
    Am J Clin Dermatol 2018 Feb 27. Epub 2018 Feb 27.
    Department of Dermatology, University of Pittsburgh, UPMC North Hills Dermatology, 9000 Brooktree Rd Suite 200, Wexford, PA, 15090, USA.
    Nail psoriasis (NP) and nail lichen planus (NLP) can be limiting, stigmatizing and difficult to treat. Dermatologists commonly treat psoriasis and lichen planus but when associated onychodystrophy is present or is an isolated finding, some develop apprehension. The goal of this review is to develop therapeutic ladders to be used as a guide for the management of NP and NLP in everyday clinical practice. Read More

    Ulcerating Lichen Planopilaris - Successful Treatment by Surgery.
    Open Access Maced J Med Sci 2018 Jan 10;6(1):96-98. Epub 2018 Jan 10.
    University of Rome G. Marconi, Institute of Dermatology, Rome 00186, Italy.
    Lichen planus is a T-cell mediated autoimmune disorder affecting the skin and mucous membranes. Ulcerating lichen planus is uncommon mostly on oral and genital mucosa but not skin. Lichen planopilaris, however, is a subtype of lichen planus affection hair follicles and leading to permanent scarring alopecia. Read More

    Oral lichenoid lesions of the upper lip and gingiva: What we know so far.
    Oral Dis 2018 Mar;24(1-2):135-137
    General and Special Care Dentistry, "Sotiria" Chest Diseases Hospital, Athens, Greece.
    The clinical presentation of oral lichen planus and oral lichenoid lesions is diverse. A special category of patients presents with lichenoid lesions affecting only the mucosa of their upper lip and the anterior upper gingiva. This is a concise review summarizing the specific characteristics of these patients. Read More

    Diagnostic and prognostic relevance of salivary microRNA-21, -125a, -31 and -200a levels in patients with oral lichen planus - a short report.
    Cell Oncol (Dordr) 2018 Feb 26. Epub 2018 Feb 26.
    Department of Oral and Maxillofacial Medicine, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.
    Background: Oral lichen planus (OLP), a relatively common chronic inflammatory disease of the oral mucosa, is considered to be a premalignant disorder of the oral cavity. Previously, several biomarkers have been tested for their diagnostic potential. Here, we aimed to investigate the diagnostic potential of four miRNAs, miR-21, -125a, -31 and -200a, known to be involved in oral squamous cell carcinoma (OSCC) development, in the saliva of OLP patients as also their putative relation to OSCC development in these patients. Read More

    Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions.
    Acta Clin Croat 2017 Sep;56(3):369-374
    Institute of Public Health, Skopje, Republic of Macedonia.
    Oral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of different HPV types with oral premalignant lesions, and the potential role of smoking and alcohol use. Read More

    Vaginal lichen sclerosus: report of two cases.
    Facts Views Vis Obgyn 2017 Sep;9(3):171-173
    Serviço de Anatomia Patológica, Centro Hospitalar de São João, Porto, Portugal.
    Background: Lichen sclerosus most commonly affects the genital area. Contrarily to lichen planus, the involvement of the oral or vaginal mucosa is rare. Only four cases of vaginal lichen sclerosus have been described in the literature. Read More

    How general dentists could manage a patient with oral lichen planus.
    Med Oral Patol Oral Cir Bucal 2018 Mar 1;23(2):e198-e202. Epub 2018 Mar 1.
    VU University Medical Center (VUmc)/ ACTA, Department of Oral and Maxillofacial Surgery and Pathology, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands,
    Background: The literature hardly contains information on how patients suffering from oral lichen planus could be managed by dentists.

    Material And Methods: Based on the limited available literature and particularly on the long-term clinical and histopathological experience of one of the authors, suggestions on how dentists could manage patients with oral lichen planus have been put forward.

    Results: In most cases, the dentist should be able to establish a correct diagnosis. Read More

    Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
    J Formos Med Assoc 2018 Feb 19. Epub 2018 Feb 19.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. Read More

    Lichen planus: molecular pathway and clinical implications in oral disorders.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):135-138
    Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Naples, Italy.
    Stem cells play a role in many mucosal disorders characterised by abnormal proliferation and differentiation of keratinocytes, such as oral lichen planus (OLP). In OLP there were changes in stem cell markers as component of integrin complexes α6 and β1 integrin increased along with increase of melanoma-associated chondroitin sulphate proteoglycan (MCSP) and decreased of notch1 (N1) and keratin 15 (K15). Stem cell marker expression may be altered by pathological signalling in these lesions. Read More

    Psychiatric disorders in oral lichen planus: a preliminary case control study.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):97-100
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    The aim of this study was to evaluate the prevalence of psychiatric symptoms in patients with oral lichen planus (OLP) compared to a control group. Eleven patients (mean age 65.2 years-old), with diagnosis of OLP and 13 controls (mean age 64. Read More

    Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus.
    Clin Exp Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Davis Medical Center, University of California-Davis, Sacramento, CA, USA.
    Background: Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy.

    Aim: To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa. Read More

    Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):701-710. Epub 2017 Nov 29.
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan.
    Hepatitis C virus (HCV) infection is frequently associated with various extrahepatic manifestations, such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one such extrahepatic manifestation of HCV infection. Recently, direct-acting antivirals (DAA) have proved to be highly effective and safe for the eradication of HCV. Read More

    Increased infiltration of CD11 c/CD123 dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 18. Epub 2017 Dec 18.
    Department of Oral Mucosal Diseases, Ninth People's Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China; National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:
    Objective: Investigation of dendritic cell (DC) subsets and expression patterns of Toll-like receptors (TLRs) was conducted to understand the pathogenesis in oral lichen planus (OLP).

    Study Design: Blood, OLP lesion, and control samples were collected. Four DC subsets (CD11cCD123myeloid DC1 [mDC1], CD141mDC2, CD11cCD123plasmacytoid DC [pDC], and CD1aCD207Langerhans cells [LC]) were investigated via flow cytometry (FCM) and immunohistochemical staining. Read More

    Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.
    J Formos Med Assoc 2018 May 7;117(5):374-380. Epub 2018 Feb 7.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Efficacy of photodynamic therapy or low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus.
    Photodiagnosis Photodyn Ther 2018 Mar 4;21:404-408. Epub 2018 Feb 4.
    Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Electronic address:
    Background: The efficacy of photodynamic therapy (PDT) or low level laser therapy (LLLT) in the treatment of oral lichen planus (OLP) is debatable. The aim of this study was to compare the effects of PDT, LLLT or topical corticosteroid application in the treatment of erosive-atrophic OLP.

    Materials And Methods: Forty-five adult patients with erosive-atrophic biopsy-proven OLP on the tongue or buccal mucosa (size ≤3 cm) were randomly divided into three groups. Read More

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