36 results match your criteria Oral Leukoplakia Idiopathic

Importance of Ki-67 Labeling in Oral Leukoplakia with Features of Dysplasia and Carcinomatous Transformation: An Observational Study over 4 Years.

South Asian J Cancer 2020 Jun 14;9(2):99-104. Epub 2020 Dec 14.

Department of Oral Pathology, North Bengal Dental College and Hospital, Darjeeling, West Bengal, India.

 Early detection of dysplastic changes within oral potentially malignant disorders is the mainstay to prevent oral cancer. Ki-67 is one of the most useful antigens in this purpose.  The study aims were to recognize and mutually compare the proliferative status of idiopathic oral leukoplakia (OL) patches, which presented through different forms of dysplasia and carcinoma. Read More

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Potentially Malignant Oral Disorders and Cancer Transformation.

Anticancer Res 2018 Jun;38(6):3223-3229

Department of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Cancer in the oral cavity is often preceded by precursor lesions. Nine oral mucosal disorders are known to have an increased risk of malignant transformation. The etiology varies from disorders caused by exogenous factors such as tobacco and autoimmune inflammation to idiopathic or inherited genetic aberrations. Read More

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Meta-analysis on clinicopathologic risk factors of leukoplakias undergoing malignant transformation.

J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):354-361

Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bengaluru, Karnataka, India.

Context: Leukoplakia is classified under the term potentially malignant disorder. This term does not suggest the clinician or the patient about the severity of the disease to undergo a malignant transformation. Thus, there arises a need to identify the risk factors associated with malignant transformation (MT) to predict it at the earliest. Read More

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October 2016


Thorakkal Shamim

J Ayub Med Coll Abbottabad 2016 Jan-Mar;28(1):213

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Current strategies for prevention of oral manifestations of human immunodeficiency virus.

Lauren L Patton

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Jan 9;121(1):29-38. Epub 2015 Sep 9.

Professor and Chair Department of Dental Ecology, CB 7450, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

Objectives: Strategies to prevent new-onset and recurrent oral manifestations of human immunodeficiency virus (HIV), including fungal, viral, neoplastic, and idiopathic mucosal diseases and destructive periodontal conditions, are poorly understood.

Study Design: A structured review of the English language literature in PubMed through March 2015 was conducted to identify current prevention strategies for initial and recurrent oral manifestations of HIV.

Results: Pharmacologic approaches, including combination antiretroviral therapy or other targeted therapies for prevention of oropharyngeal candidiasis, orolabial herpes, oral hairy leukoplakia, oral Kaposi sarcoma, linear gingival erythema and necrotizing ulcerative periodontitis were found. Read More

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January 2016

Juvenile Idiopathic Inflammatory Myopathy in a Patient With Dyskeratosis Congenita Due to C16orf57 Mutation.

J Pediatr Hematol Oncol 2016 Mar;38(2):e75-7

Department of Pediatric Immunology, Uludag University Medical Faculty, Görükle, Bursa, Turkey.

Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. A variety of noncutaneous (dental, pulmonary, gastrointestinal, neurological, genitourinary, ophthalmic, and skeletal) abnormalities also have been reported. An 8-year-old boy with DC developed juvenile idiopathic inflammatory myopathy. Read More

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The wide-ranging clinical implications of the short telomere syndromes.

Intern Med J 2016 Apr;46(4):393-403

Children's Medical Research Institute, The University of Sydney, Sydney, New South Wales, Australia.

There is an increasing number of inherited disorders in which excessive telomere shortening underlies the molecular defect, with dyskeratosis congenita (DC) being the archetypal short telomere syndrome. DC is classically described as a mucocutaneous triad of oral leukoplakia, nail dystrophy and abnormal skin pigmentation. However, excessive telomere shortening can affect almost any organ system, so the clinical manifestations are protean, including developmental delay, cerebellar hypoplasia, exudative retinopathy, aplastic anaemia, acute myeloid leukaemia, idiopathic pulmonary fibrosis, idiopathic hepatic cirrhosis, head and neck cancer and dental abnormalities, and may be multi-systemic. Read More

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Idiopathic leukoplakia- report of a rare case and review.

J Clin Diagn Res 2015 Mar 1;9(3):ZD11-2. Epub 2015 Mar 1.

Professor, Department of Oral Medicine & Radiology, The Oxford Dental College, Hospital & Research Centre , Bommanahalli, Hosur Road, Bangalore, Karnataka, India .

Idiopathic leukoplakia is a rare potentially malignant lesion, usually found on the tongue with an increased risk of malignant transformation as compared to the tobacco associated form. The risk of malignant transformation increases with age. Diagnosis poses a challenge to the clinician as it is diagnosed by exclusion of other possible causes leading to hyperkeratosis. Read More

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Isolated lichen planus of lower lip: a case report.

Indian J Otolaryngol Head Neck Surg 2015 Mar 24;67(Suppl 1):151-3. Epub 2014 Aug 24.

Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhopal, India.

Lichen planus is an idiopathic inflammatory condition, which may involve mucosa of the oral cavity, gastrointestinal tract, larynx or the cutaneous surface either in isolation or in combinations. Mucosal lichen planus is more common than the cutaneous variant. Isolated lip involvement is very rare and should be differentiated from other similar leukoplakic lesions. Read More

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Oral leukoplakia in a South African sample: a clinicopathological study.

Oral Dis 2013 Sep 4;19(6):592-7. Epub 2012 Dec 4.

Department of Oral Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objective: This study analysed differences in clinicopathological features of oral leukoplakia in different racial groups in the greater Johannesburg area of South Africa, with emphasis on the black population.

Material And Methods: The retrospective review included cases diagnosed clinically as oral leukoplakia and histologically as hyperkeratosis without dysplasia, hyperkeratosis with mild, moderate or severe dysplasia, and carcinoma in situ from 1990 to 2010. Age, gender, ethnicity, clinical appearance, site of lesion and tobacco smoking habit were recorded. Read More

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September 2013

Idiopathic proliferative verrucous leukoplakia: report of a clinical rarity.

BMJ Case Rep 2012 Aug 2;2012. Epub 2012 Aug 2.

Department of Oral Medicine and Radiology, Rungta College of Dental Sciences, Bhilai, Chhattisgarh, India.

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Rapid progression of an idiopathic leukoplakia to a proliferative verrucous leukoplakia lesion and then squamous cell carcinoma.

Quintessence Int 2012 Jul-Aug;43(7):583-5

Department of Stomatology, University of São Paulo, Brazil.

The article reports a case of oral proliferative verrucous leukoplakia (OPVL) in a 76-year-old woman, underscoring how an otherwise inconspicuous white plaque lesion can rapidly turn into a phase of verrucous carcinoma and subsequently squamous cell carcinoma. Read More

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November 2012

Oral Leukoplakia as It Relates to HPV Infection: A Review.

L Feller J Lemmer

Int J Dent 2012 28;2012:540561. Epub 2012 Feb 28.

Department of Periodontology and Oral Medicine, University of Limpopo, Medunsa Campus, Medunsa, South Africa.

Leukoplakia is the most common potentially malignant lesion of the oral cavity and can be categorised according to its clinical appearance as homogeneous or nonhomogenous. Tobacco and areca nut use, either alone or in combination are the most common risk factors for oral leukoplakia, but some oral leukoplakias are idiopathic. Some leukoplakias arise within fields of precancerized oral epithelium in which the keratinocytes may be at different stages of cytogenetic transformation. Read More

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Idiopathic linear leukoplakia of gingiva: A rare case report.

N Sapna K L Vandana

J Indian Soc Periodontol 2010 Jul;14(3):198-200

Department of Periodontics, D.A.P.M R.V. Dental College, Bangalore, India.

White lesions of the oral cavity are not uncommon though majority of them are benign. This case report documents a rare case of idiopathic linear leukoplakia of gingiva with no apparent etiology. Initial examination revealed a non-scrapable linear white lesion on the marginal and papillary gingiva of upper right teeth region. Read More

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The genetics and clinical manifestations of telomere biology disorders.

Genet Med 2010 Dec;12(12):753-64

Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.

Telomere biology disorders are a complex set of illnesses defined by the presence of very short telomeres. Individuals with classic dyskeratosis congenita have the most severe phenotype, characterized by the triad of nail dystrophy, abnormal skin pigmentation, and oral leukoplakia. More significantly, these individuals are at very high risk of bone marrow failure, cancer, and pulmonary fibrosis. Read More

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December 2010

Recent progress in dyskeratosis congenita.

Int J Hematol 2010 Oct 1;92(3):419-24. Epub 2010 Oct 1.

Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, 466-8550, Japan.

Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telomerase and telomere components have been identified in patients with DC. Read More

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October 2010

Dental students' knowledge of human immunodeficiency virus.

Y O Ajayi E O Ajayi

J Dent 2008 May 11;36(5):374-8. Epub 2008 Mar 11.

Department of Restorative Dentistry, School of Dental Sciences, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.

Objective: This study evaluated final year dental students' knowledge of human immunodeficiency virus (HIV), lesions associated with HIV, potential transmission routes of HIV, and their perception of the teaching received on cross-infection precautions, virology, sterilization practice and procedure, barrier dentistry and recognition of blood-borne virus risk group.

Methodology: Structured questionnaires on knowledge of human immunodeficiency virus were filled by final year dental students of University of Lagos, Nigeria. A total of 35 out of 37 questionnaires were returned filled giving a response rate of 94. Read More

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Epidemiological and clinicopathological study of oral leukoplakia.

Indian J Dermatol Venereol Leprol 2005 May-Jun;71(3):161-5

Department of Dermatology and Venereology, S.C.B. Medical College, Cuttack, Orissa, India.

Background: Oral white lesions that cannot be clinically or pathologically characterized by any specific disease are referred to as leukoplakia. Such lesions are well known for their propensity for malignant transformation to the extent of 10-20%. Exfoliative cytology is a simple and useful screening tool for detection of malignant or dysplastic changes in such lesions. Read More

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Incidence rates for oral leukoplakia and lichen planus in a Japanese population.

J Oral Pathol Med 2005 Oct;34(9):532-9

Department of Oral and Maxillofacial Surgery II, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.

Background: Data on the incidence rates of potentially malignant diseases of the oral cavity in different populations is meagre. This is the first study to report on the age-specific incidence of oral leukoplakia and oral lichen planus from an industrialized country.

Methods: Annual screening for oral cancer and pre-cancer was undertaken in Municipal Health Centres in Tokoname city, Japan from 1995 to 1998. Read More

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October 2005

Expression of alpha-defensin-1 in chronic hyperplastic candidosis.

J Oral Pathol Med 2005 Jul;34(6):347-51

Department of Anatomy/Biomedicum, University of Helsinki, Helsinki, Finland.

Background: Chronic hyperplastic candidosis (CHC) represents a chronic opportunistic candida infection. We clarified the presence, localization and participation of alpha-defensin-1 in host response against chronic candidal stimulus.

Methods: Immunohistochemically stained CHC biopsies (n = 10) were compared to candida negative idiopathic leukoplakia (n = 10). Read More

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Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not?

J Oral Pathol Med 2003 Aug;32(7):383-92

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

Background: Some oral verrucal lesions may constitute parts of the clinicopathological spectrum of proliferative verrucous leukoplakia (PVL). Because of its idiopathic yet sinister nature, it is possible that PVL may exist in other populations. The aim of this study was to review the clinicopathological features of persistent, multifocal, oral verrucal lesions in Malaysian population. Read More

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Oral leukoplakia: a proposal for uniform reporting.

Oral Oncol 2002 Sep;38(6):521-6

Department of Oral & Maxillofacial Surgery/Pathology, Vrije Universiteit medical centre/ACTA, PO Box 7057, Amsterdam, The Netherlands.

Leukoplakia is the most common precancerous lesion of the oral mucosa. In order to promote uniform reporting of management results, including the event of malignant transformation, recommendations have been made for the various definitions and terminologies, including the application of a certainty factor with which the diagnosis of oral leukoplakia has been established. For reporting purposes there seems to be no rationale for distinguishing "tobacco-associated" leukoplakias from non-tobaccco-associated, so-called idiopathic leukoplakias. Read More

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September 2002

Search for correlation between symptoms and signs of changes in the oral mucosa and presence of fungi.

A J Kurnatowska

Mycoses 2001 Nov;44(9-10):379-82

Department of Conservative Dentistry, Medical University of Lodź, Poland.

The aim of the present study was to determine the relationship between the symptoms and signs of oral mucosal changes and the presence of fungi. The investigation comprised 235 subjects. Fungi were detected in the oral cavities of 196 of these subjects. Read More

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November 2001

Laser management of oral leukoplakias: a follow-up study of 70 patients.

Laryngoscope 1999 Jun;109(6):949-53

University of California, Department of Stomatology, School of Dentistry, San Francisco, USA.

Objectives/hypothesis: To assess the efficacy of laser therapy for the management of premalignant oral lesions.

Study Design: The study group consisted of seventy consecutive laser-treated patients with oral leukoplakia. The microscopic diagnosis included idiopathic focal keratosis, dysplasias of all grades, and verrucous hyperplasia (proliferative verrucous leukoplakia). Read More

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Diagnosis and treatment of common oral lesions found in the elderly.

J E Fantasia

Dent Clin North Am 1997 Oct;41(4):877-90

Department of Dental Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.

A wide variety of oral lesions are recognized in the geriatric patient. The most common lesions include neoplasia, immunologic based mucosal disease, hematological disorders, oral manifestation of systemic disease, and conditions characterized by oral or facial pain. Diagnostic and treatment considerations for leukoplakia, carcinoma, metastatic disease, candidiasis, herpes zoster, plasmacytoma, myeloma, lymphoma, several of the more common vesiculoulcerative mucosal diseases and idiopathic burning mouth syndrome are presented. Read More

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October 1997

Prevalence of oral mucosal lesions in a Kenyan population with special reference to oral leukoplakia.

East Afr Med J 1995 Dec;72(12):778-82

Dental School, University of Nairobi, Kenya.

The prevalence of oral leukoplakia and related lesions in a Kenyan rural population was determined in a systematic house to house survey of individuals aged 15 years and above. Among the 803 individuals examined, the following prevalence of lesions was observed: leukoedema (26%), melanosis (12.7%), leukoplakia (10. Read More

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December 1995

Early diagnosis and prevention of oral cancer and precancer: report of Symposium III.


Adv Dent Res 1995 Jul;9(2):134-7

Oral precancer encompasses several conditions and lesions. Among those entities included in the concept are leukoplakia, erythroplakia, lichen planus, and submucous fibrosis. For prevention, knowledge about etiologic and pathogenetic factors is imperative. Read More

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Knowledge of the human immunodeficiency virus among final year dental students.

J Dent 1994 Aug;22(4):229-35

Department of Dental Surgery & Periodontology, University of Dundee, Scotland, UK.

A sound basis of knowledge about HIV infection and AIDS is essential to allow students to develop as dentists who undertake appropriate measures during clinical practice. In addition, it is also likely that possessing appropriate information may instil confidence in their own ability to diagnose and then manage patients infected by HIV. A questionnaire designed to test the knowledge of final year dental students in the UK was completed by 60. Read More

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Idiopathic leukoplakia lingualis.

Gen Dent 1993 Nov-Dec;41(6):547-9

Geriatric, Research, Education, and Clinical Center, Veterans Affairs Medical Center, 1601 SW Archer Road, Gainesville, FL 32608-1197, USA.

A 67-year-old man had a nonspecific leukoplakia of the tongue. It was of recent onset and had no readily apparent etiology. From the differential diagnosis of seven conditions, biopsy was consistent with a benign hyperkeratotic process. Read More

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