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Am J Ophthalmol Case Rep 2021 Jun 16;22:101095. Epub 2021 Apr 16.

College of Medicine, QU Health, Qatar University, Doha, Qatar.

Purpose: Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Ocular complications due to orbital IH include strabismal, deprivational, or anisometropic astigmatism, and visual loss secondary to amblyopia.

Observations: We report a case of a two-month-old female infant with a severe deep orbital IH. Read More

BMC Pulm Med 2021 May 10;21(1):156. Epub 2021 May 10.

Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: Capillary hemangioma can be found in many organs, but rarely in pleura. Previously, only localized pleural capillary hemangioma cases have been reported. Corticosteroids are the most commonly recommended drugs in capillary hemangioma. Read More

Pharmaceutics 2021 Apr 19;13(4). Epub 2021 Apr 19.

Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.

Oral propranolol hydrochloride has been the first-line treatment for infantile hemangioma (IH), whereas systemic exposure to propranolol has the potential of causing serious adverse reactions. Dermal delivery of propranolol is preferable due to high local drug concentration and fewer adverse effects. However, propranolol hydrochloride (BCS class I) is highly hydrophilic and has difficulty in penetrating the stratum corneum (SC) barrier. Read More

Wounds 2021 Feb;33(2):E17-E19

Maharashtra Institute of Medical Sciences and Research (MIMSR) Medical College Latur, India.

Introduction: Infantile hemangiomas (IHs) are the most common vascular abnormalities in children under 1 year old; most IHs involute spontaneously and do not need intervention unless a complication occurs. Ulceration and secondary infection are the most common complications. Despite appropriate conventional wound care, ulcerated IHs are difficult to heal. Read More

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA; Department of Pathology, Institute Curie, Paris, France; Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA; Department of Dermatology, Boston Children's Hospital and Harvard Medical School, Boston, MA; Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA; Department of Plastic and Oral Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA; Department of Orthopaedics, Beth Israel Deaconess Medical Center, Boston, MA; Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA; and Department of Orthopedics, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Background: Verrucous venous malformation (VVM), previously called "verrucous hemangioma," typically involves the dermis and the subcutaneous fat. We have encountered patients with VVM confined to the hypodermis.

Materials And Methods: During a nearly 20-year period, 13 patients, aged 2-17 years, presented with a subcutaneous mass in the limb without clinically obvious epidermal alterations. Read More

Drugs Context 2021 6;10. Epub 2021 Apr 6.

Department of Pediatrics and Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Infantile haemangiomas (IHs) are relatively common benign vascular tumours found in the paediatric population. They have varying sizes and involve different depths in the skin leading to various colours, shapes and textures. Although considered harmless in most cases, they may lead to life-threatening complications or cause permanent disfigurations and organ dysfunction. Read More

Sudan J Paediatr 2021 ;21(1):95-97

Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.

Salivary gland tumours are rare in children. We present the case of an infant who presented with a progressively increasing swelling of short duration in the parotid region accompanied by a small preauricular cutaneous haemangioma. Failing to comply with the commoner diagnoses like parotitis, help of imaging was taken that pointed towards the rarer diagnosis of parotid haemangioma. Read More

JAMA Otolaryngol Head Neck Surg 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatric Surgery, Chengdu Women and Children's Central Hospital, Chengdu, China.

Importance: Propranolol has become the first-line therapy for problematic infantile hemangiomas (IHs) that require systemic therapy. However, different adverse events have been reported during propranolol treatment. The positive efficacy and safety of atenolol raise the question of whether it could be used as a promising therapy for IH. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):334-338

Tatva Dental Clinic, Hyderabad, Telangana, India.

Intraosseous hemangiomas are uncommon, constituting less than 1% of all osseous tumors. The most frequent sites are the calvaria and the vertebral column. The involvement of the facial bones is rare, and if occurs, it can involve maxilla, mandible, nasal bones and zygomatic bone. Read More

Int J Appl Basic Med Res 2021 Jan-Mar;11(1):44-46. Epub 2021 Jan 26.

Department of Oral and Maxillofacial Pathology, BVDU Dental College, Sangli, Maharashtra, India.

Encephalotrigeminal angiomatosis, also called Sturge-Weber syndrome (SWS), is a syndrome of etiology which is not yet clear. It is a nonhereditary condition. The clinical features include pigmentation over the facial skin known as port-wine stain, abnormalities of ocular region, and central nervous system involvement as leptomeningeal angioma. Read More

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Department of Pediatric Surgery, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Objective: Recently, sirolimus has emerged as a safe and effective treatment modality for unresectable vascular lesions. In the present study, we investigated the effectiveness and safety of sirolimus from our early experience with patients with unresectable vascular anomalies.

Methods: The medical records and radiologic images of all patients with unresectable vascular anomalies treated with sirolimus at our center from January 2018 to November 2019 were retrospectively reviewed. Read More

JAMA Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Dermatology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Importance: Treatment of infantile hemangioma (IH) with topical timolol in the first 2 months of life (early proliferative phase) may prevent further growth and the need for treatment with oral propranolol. To our knowledge, no studies have determined whether beginning early treatment with timolol for IH is better than in other proliferative stages.

Objective: To evaluate the efficacy and safety of timolol maleate solution, 0. Read More

Dermatology 2021 Apr 6:1-9. Epub 2021 Apr 6.

Vascular Anomaly Team, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada.

Background: Off-label drug use is associated with an increased risk of adverse drug reactions. It is common in pediatrics and in rare diseases, which are two characteristics applying to vascular anomalies (VA).

Objectives: The aim of this work was to quantify off-label drug use in VA and assess its safety. Read More

Swiss Dent J 2021 Apr;131(4):327-338

Klinik für Zahnerhaltung und Präventivzahnmedizin, Zentrum für Zahnmedizin, Universität Zürich, Zürich, Schweiz.

When a syndrome forms the background of a systemic involvement of periodontal disease, it is necessary to fully exploit the resources outside, which soon reaches its limits in private practice. In the patient's environment, it must be checked whether support for the patient can be guaranteed. Without support, as in this presented case, the patient's oral hygiene could hardly be maintained. Read More

Indian Pediatr 2021 Mar 26. Epub 2021 Mar 26.

Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Objectives: To assess the adverse effects of propranolol therapy in infantile hemangioma.

Methods: An ambispective study was conducted from August 2011 to December 2019. In retrospective arm all children managed for infantile hemangioma with propranolol were included and case records were assessed for adverse reactions. Read More

Indian J Dent Res 2020 Nov-Dec;31(6):979-982

Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Teynampet, Chennai, Tamil Nadu, India.

Hemangiomas are the most common benign vascular tumours, often reported in very young. Though the head and neck regions have high predilection, intra-oral hemangiomas (IH) are very rare. In spite of numerous treatment options, the IH are ideal candidates for surgical exoneration. Read More

Paediatr Child Health 2021 Apr-May;26(2):e70-e72. Epub 2020 Apr 24.

Department of Pediatrics and Department of Dermatology and Skin Sciences, The University of British Columbia, Vancouver, British Columbia.

The majority of infantile hemangiomas are benign and will resolve on their own. We report a 4-month-old infant with an ulcerated giant segmental infantile hemangioma involving the left upper limb who developed a contracture of the left elbow despite treatment with oral propranolol, proper wound care, and regular intense physiotherapy. To our knowledge, contracture resulting from an infantile hemangioma has not been reported previously. Read More

Cesk Slov Oftalmol 2021 ;77(1):36-44

Pachychoroid disease of retina is a spectrum of diseases manifested by thickening and hyperperfusion of the choroid with changes in the sensory part of the retina. The main unit of this group is central serous chorioretinopathy (CSC). In practice, we often encounter other conditions, which are manifested by thickening of the choroid and changes in the retina, but they cannot be classified as pachychoroid diseases. Read More

Dermatol Ther 2021 Mar 11:e14936. Epub 2021 Mar 11.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Propranolol emerged as the first-line therapy for infantile hemangioma (IH). Determinants of interindividual variation in drug response and predictors of rebound growth after drug discontinuation are yet to be firmly established. We aimed to evaluate the outcomes of a relatively large cohort of patients with IH treated by propranolol and to determine predictors of (a) an excellent response to treatment (≥90 improvement) and (b) of rebound growth after drug cessation. Read More

Oral Radiol 2021 Mar 3. Epub 2021 Mar 3.

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.

Objectives: Oral hemangioma is a benign vascular tumor characterized by the presence of numerous blood vessels. We aimed to examine the clinical and ultrasonographic findings of patients diagnosed with oral hemangioma in our ultrasonography (USG) archive, retrospectively.

Methods: This study was conducted by examining 20 patients diagnosed with oral hemangioma and underwent USG examination in the Department of Oral and Maxillofacial Radiology of Atatürk University Faculty of Dentistry from 2016 to 2020. Read More

Front Surg 2020 9;7:610758. Epub 2021 Feb 9.

Gillies McIndoe Research Institute, Wellington, New Zealand.

Treatment of vascular anomalies (VAs) is mostly empirical and, in many instances unsatisfactory, as the pathogeneses of these heterogeneous conditions remain largely unknown. There is emerging evidence of the presence of cell populations expressing stemness-associated markers within many types of vascular tumors and vascular malformations. The presence of these populations in VAs is supported, in part, by the observed clinical effect of the mTOR inhibitor, sirolimus, that regulates differentiation of embryonic stem cells (ESCs). Read More

Cleft Palate Craniofac J 2021 Feb 15:1055665621993298. Epub 2021 Feb 15.

Department of Child and Adolescent Psychiatry/Psychology, 97759Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

Objective: Parents of children with a medical condition and a visible difference can experience challenging situations. We evaluated distress and parenting stress in parents of children with a cleft lip with or without cleft palate (CL±P) or a visible infantile hemangioma (IH).

Setting: This cross-sectional study took place in an academic medical hospital in Rotterdam, the Netherlands. Read More

Biomed Res Int 2021 27;2021:6636891. Epub 2021 Jan 27.

Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.

Objective: Infantile hemangiomas (IHs) are the most common benign tumors in infancy. The purpose of this study was to study the effects of propranolol on the function of human umbilical vein endothelial cells (HUVECs), in order to preliminarily elucidate the mechanism of propranolol in the treatment of IHs.

Methods: HUVECs were treated with different concentrations of propranolol (30 M, 60 M, 90 M, and 120 M) with or without VEGF. Read More

Ann Transl Med 2021 Jan;9(2):116

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Infantile hemangiomas (IHs) are the most frequently occurring pediatric lesions. Oral propranolol has been shown to be safe and effective in infants with IHs. Side effects such as sleep disturbances have been associated with propranolol. Read More

J Surg Case Rep 2021 Jan 29;2021(1):rjaa523. Epub 2021 Jan 29.

Department of General Surgery, Gold Coast University Hospital, Gold Coast, Australia.

Rupture of a liver haemangioma is extremely rare, with less than 100 cases reported in the literature. This is the first case known to date reporting a rupture occurring with direct oral anticoagulant therapy. A 76-year-old woman presented with acute abdominal pain and syncope in the context of commencing apixaban 4 weeks prior. Read More

Head Neck 2021 May 4;43(5):1553-1562. Epub 2021 Feb 4.

Department of Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: The outcomes of propranolol treatment remain controversial for parotid hemangiomas, which may be inferior to outcomes for infantile hemangiomas (IHs) at other sites.

Methods: Patients with IHs treated with oral propranolol were retrospectively reviewed. Outcomes of propranolol therapy for parotid hemangiomas and other IHs were examined. Read More

Ther Clin Risk Manag 2021 27;17:119-125. Epub 2021 Jan 27.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, People's Republic of China.

Background: Infantile hemangioma (IH) is the most common benign tumor in children. However, few studies have reported the clinical features of segmental IH. We aimed to determine the clinical characteristics of segmental IH and to identify features that may aid clinicians in managing segmental IH. Read More

J Ocul Pharmacol Ther 2021 Mar 3;37(2):112-130. Epub 2021 Feb 3.

Division of Neonatal/Perinatal Medicine, Department of Pediatrics, State University of New York, Brooklyn, New York, USA.

Propranolol, a nonselective B1/B2 adrenoceptor antagonist, promotes the regression of infantile hemangiomas likely through suppression of vascular endothelial growth factor (VEGF), which prompted its use for the prevention of retinopathy of prematurity. We tested the hypothesis that topical ocular propranolol is safe and effective for reducing the severity of oxygen-induced retinopathy (OIR) in the neonatal rat intermittent hypoxia (IH) model. At birth (P0), rat pups were randomly assigned to room air or neonatal intermittent hypoxia (IH) consisting of 50% O with brief episodes of hypoxia (12% O) from P0 to P14, during which they received a single daily dose of oral propranolol (1 mg/kg/day in 50 μL in sterile normal saline) or topical ocular propranolol (0. Read More

Pediatr Dermatol 2021 Mar 29;38(2):469-471. Epub 2021 Jan 29.

Dermatology Department, Hospital Universitari Son Espases, Majorca, Spain.

In the last few years, the use of oral sirolimus has shown promising results in the treatment of some complex vascular anomalies, and recently, it has been used in patients with Sturge-Weber syndrome (SWS). We present the case of an 11-year-old girl with the diagnosis of SWS and hemifacial overgrowth treated with oral sirolimus. Throughout the eight months of follow-up, improvement of the port-wine birthmark, intraocular pressure, and neurocognitive development was noted. Read More

J Cutan Pathol 2021 Jan 23. Epub 2021 Jan 23.

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, São Paulo, Brazil.

Background: Pyogenic granuloma (PG) is a lesion characterized by the proliferation of blood vessels, commonly affecting the skin and the mouth. We aimed to compare clinical, microscopic, and immunohistochemical features of the two types of oral PG: lobular capillary hemangioma (LCH) and non-LCH (NLCH).

Methods: Epidemiological and clinical data from 2000 to 2018 were collected from the archives of our institution, and histopathological sections of PG were reviewed. Read More