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    2159 results match your criteria Oral Hemangiomas

    1 OF 44

    Safety and effectiveness of oral propranolol for infantile hemangiomas started before 5 weeks and after 5 months of age: an Italian multicenter experience.
    Ital J Pediatr 2017 Apr 19;43(1):40. Epub 2017 Apr 19.
    Angioma Center, Cardiovascular Department, Gaslini Children's Research Institute, Genoa, Italy.
    Background: Despite not being licensed for the treatment of infantile hemangiomas (IH) in infants younger than 5 weeks or older than 5 months, propranolol is often used in these age groups to prevent or to treat potentially severe complications. The objective of the present study was to review the experience of 8 Italian pediatric and dermatologic centers regarding propranolol treatment for IH started before 5 weeks or after 5 months of age.

    Methods: We retrospectively reviewed the records of patients followed up for IH, on propranolol treatment started before 5 weeks or after 5 months of age, and collected information on sociodemographic data, treatment indications, IH involution, IH relapse, and treatment side effects. Read More

    One-Stage Supramaximal Full-Thickness Wedge Resection of Vascular Lip Anomalies.
    J Oral Maxillofac Surg 2017 Mar 22. Epub 2017 Mar 22.
    Staff, Vascular Birthmark Institute of New York, Department of Otolaryngology, Lenox Hill and Manhattan Eye, Ear, and Throat Hospitals, New York, NY; Assistant Clinical Professor, Department of Ophthalmology, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. Read More

    Nasal glial heterotopia or congenital hemangioma? A case report.
    J Stomatol Oral Maxillofac Surg 2017 Apr 5. Epub 2017 Apr 5.
    Grenoble University Hospital, Department of Maxillo-facial Surgery, Avenue Maquis du Grésivaudan, 38700 La Tronche, France.
    Nasal glial heterotopia (NGH) is a rare benign tumor of the median line. We describe the case of a child presenting a lateral nasal mass. The characteristics of the prenatal ultrasound and the postnatal clinical examination argued in favor of a congenital hemangioma (CH). Read More

    TREATMENT OF VASCULAR LESIONS LOCATED IN THE LIP AND IN THE ORAL CAVITY WITH ND-YAG LASER.
    J Cosmet Laser Ther 2017 Apr 7. Epub 2017 Apr 7.
    a Hospital Federal da Lagoa , Rio de Janeiro, Brazil.
    Vascular lesions are common complaints reported in clinics and patients seeking treatment for aesthetic or functional issues. Vascular lesions such as hemangiomas can be found in the oral cavity and some therapeutic modalities can be used in the treatment of these lesions, which the Nd: YAG laser shows good results for easy implementation, fewer complications and satisfactory results. This study describes technique and outcome of a case of hemangioma located on the tongue treated with Nd: YAG laser. Read More

    Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck.
    Sci Rep 2017 Mar 23;7(1):342. Epub 2017 Mar 23.
    Department of Oral and Maxillofacial Surgery, Qilu Hospital, and Institute of Stomatology, Shandong University, Jinan, 250012, China.
    Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2. Read More

    Psoriasiform Diaper Rash Possibly Induced by Oral Propranolol in an 18-Month-Old Girl with Infantile Hemangioma.
    Case Rep Dermatol 2016 Sep-Dec;8(3):369-373. Epub 2016 Dec 22.
    Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
    Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. Read More

    Infantile Hemangioma of the Posterior Fossa in a Newborn: Early Management and Long-Term Follow-up.
    Neuropediatrics 2017 Mar 16. Epub 2017 Mar 16.
    Unité de Neurologie Pédiatrique, Hôpital des Enfants, CHU Purpan, Toulouse, France.
    A 21-day-old male infant was admitted with signs of intracranial hypertension. Brain magnetic resonance imaging (MRI) revealed a voluminous mass in the posterior fossa with an intense peripheral enhancement on T1 images with gadolinium. The child was treated secondarily by surgical decompression of the posterior fossa and the lesion was biopsied. Read More

    [Chinese expert consensus on the use of topical timolol maleate treatment of infantile hemangiomas].
    Shanghai Kou Qiang Yi Xue 2016 Dec;25(6):744-747
    Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.
    Non-selective β-blocker propranolol has been proved by FDA as the first-line agent for infantile hemangioma (IH) with dramatic response. To reduce the side effects caused by systemic administration of propranolol, timolol maleate treatment has been increasingly used as an alternative to systemic β-blockers and watchful waiting for many IH patients in recent years. However, the appropriate indications, drug dosage, dosing regimen, time for initiation, optimal duration, monitoring for side effects still remains controversial. Read More

    Consensus statement for the treatment of infantile haemangiomas with propranolol.
    Australas J Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Royal Children's Hospital, Melbourne, Victoria, Australia.
    Although most infantile haemangiomas do not require treatment due to a natural history of spontaneous involution, some require early intervention. The Australasian Vascular Anomalies Network and the Australasian Paediatric Dermatology Network have developed a consensus statement for the treatment of infantile haemangiomas with oral propranolol. Infants with haemangiomas that are life threatening, at risk of ulceration, or at risk of causing a significant functional impairment, psychological impact or physical deformity should be treated early with oral propranolol. Read More

    When to stop propranolol for infantile hemangioma.
    Sci Rep 2017 Feb 22;7:43292. Epub 2017 Feb 22.
    From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
    There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    Zygomatic Intraosseous Hemangioma: Case Report and Literature Review.
    Craniomaxillofac Trauma Reconstr 2017 Mar 4;10(1):1-10. Epub 2016 Nov 4.
    Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Intraosseous hemangiomas are uncommon intrabony lesions, representing approximately 0.5 to 1% of all intraosseous tumors. Their description varies from "benign vasoformative neoplasms" to true hamartomatous proliferations of endothelial cells forming a vascular network with intermixed fibrous connective tissue stroma. Read More

    Sinonasal Hemangioma: Diagnosis, Treatment, and Follow-Up of 37 Patients at a Single Center.
    J Oral Maxillofac Surg 2017 Jan 5. Epub 2017 Jan 5.
    Professor, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University, Jeonju, Korea; and Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. Electronic address:
    Purpose: Hemangioma is a common benign vascular lesion of the head and neck region. It rarely involves the mucous membranes of the nasal cavity and paranasal sinuses. It should be added to the differential diagnosis of nasal cavity masses when the presenting symptoms are epistaxis or nasal obstruction. Read More

    Intraosseous Cavernous Hemangioma in the Mandible: A Case Report.
    J Clin Exp Dent 2017 Jan 1;9(1):e153-e156. Epub 2017 Jan 1.
    MD, Specialist Doctor of Medicine; Ministry of Health Turkish Public Hospitals Institution Association of Antalya Public Hospitals Serik State Hospital, Department of Pathology, Antalya/Turkey.
    Intraosseous vascular lesions are rare conditions. They are most commonly seen in the vertebral column and skull; nevertheless, the mandible is a quite rare location. In this report, we present a case of intraosseous cavernous hemangioma in the mandible and discuss the clinical and radiological features. Read More

    Benign vascular lesions of the lips: Diagnostic approach.
    J Cutan Pathol 2017 May 16;44(5):451-455. Epub 2017 Feb 16.
    School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
    Background: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In this study, vascular lesions occurring in the lips were retrieved from an Oral Pathology Service.

    Methods: Among 5600 biopsies, 131 cases were found. Read More

    Infantile haemangioma.
    Lancet 2017 Jan 12. Epub 2017 Jan 12.
    Departments of Paediatrics and Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.
    With a prevalence of 4·5%, infantile haemangiomas are the most common benign tumours of infancy, arising in the first few weeks of life and exhibiting a characteristic sequence of growth and spontaneous involution. Most infantile haemangiomas do not require therapy. However, to identify at-risk haemangiomas, close follow-up is crucial in the first weeks of life; 80% of all haemangiomas reach their final size by 3 months of age. Read More

    Infantile Intraosseous Maxillary Hemangioma.
    Indian Pediatr 2016 Dec;53(12):1103-1104
    Departments of Otorhinolaryngology and Head and Neck Surgery, and *Pathology, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India. Correspondence to: Dr Divya Gupta, Department of Otolaryngology and Head and Neck Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.
    Background: Primary osseous hemangiomas of the facial skeleton mimic malignancy. Their location in maxillary sinus, especially in infants is extremely rare.

    Case Characteristics: 1- month-old full term boy with maxillary swelling. Read More

    Oral propranolol for infantile hemangiomas: a prospective study on the role of 48-hour Holter monitoring in additional safety assessment.
    J Dermatolog Treat 2017 Jan 11:1-8. Epub 2017 Jan 11.
    a Department for Cardiology , University Children's Hospital Tirsova , Belgrade , Serbia.
    Purpose: Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication.

    Materials And Methods: Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Read More

    Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts.
    Matrix Biol 2016 Dec 20. Epub 2016 Dec 20.
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, United States; Department of Oral and Maxillofacial Surgery/Skeletal Biology Research Center, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA, United States. Electronic address:
    Our previous studies of Antxr1 knockout mice suggested that fibrotic skin abnormalities in these mice are associated with increased VEGF signaling. Here, based on studies of primary fibroblasts isolated from skin of Antx1+/+ and Antxr1-/- mice at embryonic stage E17.5 and postnatal day P49, we conclude that increased Col1a1 and Fn1 expression in Antxr1-deficient fibroblasts is partly mediated by a cell-autonomous ANTXR1-dependent mechanism. Read More

    Utility of sodium tetradecyl sulfate sclerotherapy from benign oral vascular lesion.
    Maxillofac Plast Reconstr Surg 2016 Dec 25;38(1):44. Epub 2016 Nov 25.
    Department of Oral & Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 South Korea.
    Background: Hemangioma and vascular malformation are benign vascular lesions that often occur in cephalic and cervical region. Currently, surgical resection, laser therapy, angiographic embolization, use of steroids, and sclerotherapy are used as treatments.

    Case Presentation: This study reports three cases of benign vascular lesions that are remarkably treated by sodium tetradecyl sulfate (STS) injection, of which occurred in oral cavity and around the mouth. Read More

    Sclerotherapy of Intraoral Superficial Hemangioma.
    Case Rep Dent 2016 23;2016:4320102. Epub 2016 Nov 23.
    Department of Oral Surgery, Medical Faculty, University of Prishtina, Dental Branch, 10000 Prishtina, Kosovo.
    Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. Read More

    Report of a case of acinic cell carcinoma of the upper lip and review of Japanese cases of acinic cell carcinoma of the minor salivary glands.
    J Clin Exp Dent 2016 Dec 1;8(5):e638-e644. Epub 2016 Dec 1.
    Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.
    Acinic cell carcinoma (ACC) is a malignant tumor of the salivary glands. The majority of ACCs occur in the parotid gland, and ACCs of the minor salivary glands (MSGs) are relatively infrequent. We describe here a patient with ACC of the upper lip. Read More

    Diagnostic approach to intramasseteric nodules.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan 15;123(1):e16-e21. Epub 2016 Oct 15.
    Oral Diagnosis Department, Semiology and Oral Pathology, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Sao Paulo, Brazil. Electronic address:
    Intramuscular nodules can be the clinical presentation of several groups of lesions, such as reactive disorders and benign and malignant tumors. Here, we present three cases with similar clinical features and image aspects on Doppler ultrasonography. Two of the lesions were diagnosed as intramasseteric hemangioma and the third as intramasseteric metastasis from high-grade pleomorphic sarcoma of the thigh. Read More

    The clinico-radiological spectrum of masseteric venous malformation: Case report.
    J Oral Biol Craniofac Res 2016 Nov 26;6(Suppl 1):S58-S61. Epub 2015 Sep 26.
    Reader, Department of Periodontology, People's Dental Academy, Bhopal, India.
    Due to its location, intra-masseteric venous malformation often mistaken for a parotid swelling and clinical examination alone frequently underestimates the deep extension of the lesion and rarely gives accurate pre-operative diagnosis. But once it is diagnosed, the feasibility of the treatment and the plan of approach depend on accurate delineation of the extent, size and location of the lesion. Therefore, complimentary radiographic studies are essential for its management. Read More

    Hemangioma of the oral and perioral region: Nd:YAG vs surgery.
    Ann Ital Chir 2016 Oct 14;2578. Epub 2016 Oct 14.
    Introduction: Hemangiomas are very commonly diagnosticated in childhood. The area most affected by this disease is the head and neck. In recent decades, the laser therapy has changed the treatment of hemangiomas through special techniques with advantages in bleeding risk management. Read More

    [Unexpected cutaneous purpura in an infant].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Nov;18(11):1154-1157
    Department of Dermatology, Hunan Children's Hospital, Changsha 410007, China.
    A two-month-old boy visited the hospital due to unexpected cutaneous purpura and thrombocytopenia for 2 days. The physical examination revealed a purple mass on the back. The soft tissue color Doppler ultrasound showed rich blood signals in the tissue, and the results of bone marrow puncture indicated an increased number of megakaryocytes. Read More

    Clinical Outcomes of Infants With Periorbital Hemangiomas Treated With Oral Propranolol.
    J Oral Maxillofac Surg 2016 Nov 2;74(11):2193-2199. Epub 2016 May 2.
    Professor and Chairman, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China. Electronic address:
    Purpose: Periorbital infantile hemangiomas (IHs) require early intervention because they have the potential risk of causing visual disturbances. In recent years, propranolol has shown promise in the effective management of periocular and periorbital IHs. The objective of our study was to assess the clinical outcomes, efficacy, and safety of propranolol in the management of infants with high-risk periorbital IHs. Read More

    Spindle cell haemangioma of the tongue.
    J Cutan Pathol 2016 Nov 19;43(11):1025-1027. Epub 2016 Aug 19.
    Oral and Maxillofacial Department, Royal United Hospital Bath, Bath, UK.
    Background: Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor that rarely occurs in the mouth.

    Methods And Results: We present an SCH arising in the tongue of a 52-year-old otherwise healthy woman. SCH should be considered in the differential diagnosis of vascular tumors in the oral cavity and not misinterpreted as a more aggressive vascular tumor. Read More

    Therapeutic Effect of Propranolol in Mexican Patients with Infantile Hemangioma.
    Drugs Real World Outcomes 2016 Mar;3(1):25-31
    Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana, Mexico.
    Background: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors.

    Objective: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol. Read More

    Safety of Oral Propranolol for the Treatment of Infantile Hemangioma: A Systematic Review.
    Pediatrics 2016 Oct;138(4)
    Pierre Fabre Dermatologie, Lavaur, France.
    Background And Objectives: Given the widespread use of propranolol in infantile hemangioma (IH) it was considered essential to perform a systematic review of its safety. The objectives of this review were to evaluate the safety profile of oral propranolol in the treatment of IH.

    Methods: We searched Embase and Medline databases (2007-July 2014) and unpublished data from the manufacturer of Hemangiol/Hemangeol (marketed pediatric formulation of oral propranolol; Pierre Fabre Dermatologie, Lavaur, France). Read More

    Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma.
    JCI Insight 2016 Sep 8;1(14):e88856. Epub 2016 Sep 8.
    Department of Otolaryngology - Head and Neck Surgery, University of Washington, Seattle, Washington, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington, USA.
    Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1-expressing (GLUT-1-expressing) IH endothelial cells and in the plasma of children with IH. Read More

    A Solitary Phlebolith in the Buccal Mucosa: Report of a Rare Entity and Clinicopathologic Correlation.
    J Contemp Dent Pract 2016 Aug 1;17(8):706-10. Epub 2016 Aug 1.
    Department of Oral and Maxillofacial Pathology, Vishnu Dental College and Hospital, Bhimavaram, Andhra Pradesh India.
    Pathological conditions can give rise to calcifications within oral mucosa representing either a local or systemic disturbance. Inflammation, trauma, debris acting as nidus and vascular lesions have been attributed as principal causes for occurrence of calcifications within the oral mucosa. Occurrence of multiple calcified thrombi (phleboliths) is considered pathognomonic for hemangiomas and vascular malformations in the oral and maxillofacial region. Read More

    [A clinical case of hemangioma of the face and tongue concurrent with severe obstructive sleep apnea syndrome complicated by cardiac arrhythmias and conduction disturbances].
    Ter Arkh 2016;88(8):105-10
    A.L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex, Ministry of Health of Russia, Moscow, Russia.
    The paper describes a clinical case of a female patient with severe obstructive sleep apnea syndrome in the presence of congenital hemangioma of the face, soft palate, and tongue concurrent with paroxysmal atrial fibrillation and atrial flutter, paroxysmal supraventricular tachycardia, and sinoatrial block (maximally up to 3.9 sec). Continuous positive airway pressure therapy could reduce the number of paroxysms of atrial fibrillation and atrial flutter, supraventricular tachycardia and eliminate sinoatrial block. Read More

    [Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas].
    Shanghai Kou Qiang Yi Xue 2016 Jun;25(3):257-60
    Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.
    Infantile hemangioma (IH) is one of the most common benign vascular tumors in children. A variety of treatment methods have been documented for the management of IH over the past years, including pharmacotherapy via oral administration or injection of corticosteroids, vincristine, alpha interferon and bleomycin; laser therapy, radionuclide therapy, cryotherapy and excisional surgery. The therapeutic efficacy of each treatment modality is variable, while adverse effects or complications are common and sometimes serious. Read More

    Sclerotherapy and cryotherapy in the management of oral vascular lesions: a series of 10 cases.
    Gen Dent 2016 Sep-Oct;64(5):25-9
    Vascular anomalies such as hemangiomas or vascular malformations can produce negative esthetic effects in the maxillofacial region. These negative effects are the main complaints of patients. The clinical therapeutic efficacy of cryotherapy and sclerotherapy in the treatment of these lesions was evaluated in 10 patients who were clinically diagnosed with vascular lesions. Read More

    Evaluation of the efficacy and safety of topical timolol maleate combined with oral propranolol treatment for parotid mixed infantile hemangiomas.
    Oncol Lett 2016 Sep 7;12(3):1806-1810. Epub 2016 Jul 7.
    Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang, Liaoning 110002, P.R. China.
    The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1. Read More

    Use of Propranolol for Treating Hemangiomas in Infants with Previously Diagnosed Hypoglycemic Conditions.
    Pediatr Dermatol 2016 Nov 30;33(6):e381-e384. Epub 2016 Aug 30.
    Division of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA.
    Infantile hemangiomas (IHs) are the most common pediatric vascular tumors. They require therapy when they cause severe complications such as ulceration, amblyopia, or airway constriction. Propranolol is the only treatment that the U. Read More

    Topical Treatment of Infantile Haemangiomas: A Comparative Study on the Selection of a Semi-Solid Vehicle.
    Skin Pharmacol Physiol 2016 18;29(4):210-9. Epub 2016 Aug 18.
    Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.
    Background/aim: Topical β-blockers have recently been proposed as a valid alternative to oral drugs for treating cutaneous infantile haemangiomas, but clinical results in the literature are inconsistent due to the empirical choice of topical preparations. The current investigation aimed to rationalize the selection of a semi-solid vehicle for a locally applied drug product containing 1% w/w propranolol hydrochloride (PR-Cl).

    Methods: A hydrophobic ointment of PR-Cl, two lipophilic creams, and a hydrophilic cream were prepared. Read More

    Clinical features and management of multifocal hepatic hemangiomas in children: a retrospective study.
    Sci Rep 2016 Aug 17;6:31744. Epub 2016 Aug 17.
    Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
    Multifocal hepatic hemangioma (MHH) is a benign hepatic tumor that is commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present a review of all children with MHH at our institutions. Of the 42 patients, the median age at presentation of MHH was 2. Read More

    Topical Timolol Maleate Treatment of Infantile Hemangiomas.
    Pediatrics 2016 Sep 15;138(3). Epub 2016 Aug 15.
    University of California, San Francisco, San Francisco, California;
    Background: There has been a dramatic increase in the off-label use of ophthalmic timolol maleate, a β-blocker used for infantile hemangioma (IH) treatment as a topical counterpart to oral propranolol. Its safety and efficacy in a pediatric population with IH have not been evaluated in a large cohort. Our goal was to retrospectively assess timolol's effectiveness, discern characteristics associated with response, and document reported adverse events. Read More

    Intramuscular hemangioma of the masseter muscle- a case report and review of literature.
    Int J Surg Case Rep 2016 25;26:209-16. Epub 2016 Jul 25.
    Department of Oral and Maxillofacial Pathology, Trivandrum, Kerala, India. Electronic address:
    Introduction: Intramuscular hemangioma, is a distinctive type of vascular tumor occurring within the skeletal muscle. Most IMH are located in the lower extremity, particularly in the muscles of the thigh and rarely in head and neck region.

    Presentation Of Case: 35 years old male reported with a swelling in the left cheek region since 3 years. Read More

    Recurrent multifocal cutaneous Kaposiform hemangioendothelioma: A rare vascular tumor of infancy and childhood.
    Indian J Pathol Microbiol 2016 Jul-Sep;59(3):392-4
    Department of Pathology, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India.
    Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor of childhood although cases occurring in adulthood are also described. The features overlap with juvenile capillary hemangioma and Kaposi sarcoma. We report a rare case of recurrent, multifocal (nose and chin) cutaneous KHE initially occurring in a 3-year-old female child, uncomplicated by Kasabach-Merritt syndrome. Read More

    Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study.
    Pathol Res Pract 2016 Sep 18;212(9):761-6. Epub 2016 May 18.
    Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address:
    In view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n=10), inflammatory fibrous hyperplasia (IFH, n=10), peripheral giant cell lesion (PGCL, n=10) and lobular capillary hemangioma (LCH, n=7) were investigated using immunohistochemistry for mast cell tryptase and CD34. For comparative purposes, central giant cell lesions (CGCL, n=5) were included. Read More

    Corticosteroids as an adjunct to propranolol for infantile haemangiomas complicated by recalcitrant ulceration.
    Br J Dermatol 2017 Apr 2;176(4):1064-1067. Epub 2017 Feb 2.
    Department of Dermatology, Division of Pediatric Dermatology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Unit 2107, Baltimore, 21287, MD, U.S.A.
    A small subset of patients with infantile haemangiomas (IHs) can present with serious complications, the most common of which is ulceration. Ulcerated IHs can be extremely painful and always result in scarring. Numerous studies support the efficacy and reduced side-effects of propranolol relative to systemic corticosteroids, which led to the adoption of propranolol as the mainstay of IH treatment. Read More

    Low-dose propranolol for infantile hemangioma of the head and neck: Analysis of 23 consecutive patients.
    Pediatr Int 2017 Feb 20;59(2):213-217. Epub 2016 Nov 20.
    Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Background: More and more infantile hemangiomas (IH) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute. The aim of this observational study was to describe the therapeutic response, tolerance, and safety of low-dose propranolol in 23 children with IH of the head and neck.

    Methods: Data were collected from the medical charts of patients treated with low-dose propranolol from December 2009 through November 2011. Read More

    Effective treatment for infantile hemangioma with long-pulsed dye laser with oral propranolol medication: a preliminary report.
    Pediatr Surg Int 2016 Sep 26;32(9):857-62. Epub 2016 Jul 26.
    Department of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 241-8511, Japan.
    Purpose: To investigate the efficacy of our treatment of infantile hemangioma (IH)s retrospectively presenting as disfiguring or functionally threatening lesions.

    Materials And Methods: 25 infants with IH treated with long-pulsed dye laser or laser with or without propranolol. Tumor fading after treatment was evaluated using both color and size rating scales, before, during and after treatment. Read More

    Severe Edema After Sclerotherapy of Labial Hemangioma With Ethamolin Oleate in a Young Child.
    J Craniofac Surg 2016 Sep;27(6):e567-8
    *Surgery and Integrated Clinic Department, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba †School of Post-graduate Quixadaense (EQUIP), Quixadá, Brazil.
    Adverse reactions related to ethanolamine oleate (EO) include pain during injection, redness, inflammation, tissue necrosis, and allergic reaction. The authors report a patient of exuberant facial edema after the injection of EO used in sclerotherapy of lip hemangioma in a child. A 9-year-old boy was referred to authors' oral and maxillofacial surgery unit to treat a vascular lesion of the upper lip. Read More

    Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia.
    Case Rep Gastrointest Med 2016 15;2016:4398401. Epub 2016 Jun 15.
    Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
    Pyogenic granuloma (PG), more accurately known as lobular capillary hemangioma, is a benign vascular tumor that usually occurs in the skin or oral mucosa. This lesion is rarely reported in the gastrointestinal tract but is known to bleed if not resected. We herein describe a case series with the clinical, endoscopic, and histologic findings of four cases of gastrointestinal PG at our institution. Read More

    Resection of Giant Hemangioma of the Tongue Utilizing a Miniature Tourniquet Technique.
    J Craniofac Surg 2016 Jul;27(5):e447-50
    West Bloomfield, MI.
    With the progress of multidisciplinary vascular anomaly treatment, the use of radiotherapy, cryotherapy, laser therapy and medical treatments, the corticosteroid, sclerotherapy, and many more, the role of surgery has been refined. Surgical treatment has historically been the mainstay of treatment and will maintain.A miniature tourniquet technique applied to the tongue was successfully utilized in reducing bleeding to a minimum during surgical resection of a massive cavernous hemangioma involving the tongue and lower lip without any postoperative complications. Read More

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