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Front Neurosci 2019 31;13:33. Epub 2019 Jan 31.

INSERM U1220 Institut de Recherche en Santé Digestive, CHU Purpan, Université Toulouse III Paul Sabatier, Toulouse, France.

Propranolol is the first-line treatment for infants suffering from infantile hemangioma. Recently, some authors raised the question of potential neurologic side effects of propranolol due to its lipophilic nature and thus its ability to passively cross the blood-brain barrier (BBB) and accumulate into the brain. Hydrophilic beta-blockers, such as atenolol and nadolol, where therefore introduced in clinical practice. Read More

Cell Struct Funct 2019 Feb 2. Epub 2019 Feb 2.

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine.

Infantile hemangioma is the most common soft tissue tumors in childhood. In clinic, propranolol is widely used for infantile hemangioma therapy. However, some of the infantile hemangioma patients display resistance to propranolol treatment. Read More

Pediatr Blood Cancer 2019 Jan 22:e27614. Epub 2019 Jan 22.

Vascular Anomalies Center, Division of Hematology/Oncology, Cancer and Blood Disorders Center, Boston Children's Hospital, Boston, Massachusetts.

Background: Generalized lymphatic anomaly (GLA) and Gorham-Stout disease (GSD) are rare complicated lymphatic malformations that occur in multiple body sites and are associated with significant morbidity and mortality. Treatment options have been limited, and conventional medical therapies have been generally ineffective. Emerging data suggest a role for sirolimus as a treatment option for complex lymphatic anomalies. Read More

Dent Med Probl 2018 Oct-Dec;55(4):405-410

Department of Periodontology, Faculty of Dentistry, Wroclaw Medical University, Poland.

Background: The morbidity of certain oral pathologies, for example denture-related stomatitis, burning mouth syndrome (BMS) and benign neoplasms is higher in the elderly. It is necessary to periodically assess the changes in the profile of the occurrence of these diseases and determine the dominant risk factors associated with their incidence.

Objectives: The aim of the study was to evaluate the prevalence of oral mucosal pathologies (in particular, potentially malignant and cancerous disorders) in a randomly selected population of 65-74-year-old residents of Wrocław and Oława, Poland. Read More

J Dermatol 2019 Jan 10. Epub 2019 Jan 10.

National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Front Oncol 2018 18;8:605. Epub 2018 Dec 18.

Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Infantile hemangiomas (IHs) are the most common vascular tumors of infancy. Oral propranolol has achieved great success in treating IHs since 2008. To minimize the systemic side events caused by oral administration of propranolol, topical timolol started to be applied in the treatment of IHs, especially for superficial lesions. Read More

Am J Clin Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China.

Background: Concerns have been raised that propranolol treatment of infantile hemangioma (IH) may be associated with increased risks of adverse effects and growth impairment in preterm infants due to their immature development.

Objective: This study aimed to find out whether treatment of IH with propranolol in preterm infants is associated with higher incidences of long-term adverse effects and growth impairment in comparison with term infants.

Methods: The clinical data of 55 preterm infants and 180 term infants with IH treated with oral propranolol for 6 months were retrospectively collected and analyzed. Read More

Nat Protoc 2019 Feb;14(2):541-555

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Neurofibromatosis type II (NF2) is a disease that lacks effective therapies. NF2 is characterized by bilateral vestibular schwannomas (VSs) that cause progressive and debilitating hearing loss, leading to social isolation and increased rates of depression. A major limitation in NF2 basic and translational research is the lack of animal models that allow the full spectrum of research into the biology and molecular mechanisms of NF2 tumor progression, as well as the effects on neurological function. Read More

In Vivo 2019 Jan-Feb;33(1):251-254

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Read More

Pediatrics 2019 Jan;143(1)

College of Physicians and Surgeons, Columbia University, New York City, New York.

Infantile hemangiomas (IHs) occur in as many as 5% of infants, making them the most common benign tumor of infancy. Most IHs are small, innocuous, self-resolving, and require no treatment. However, because of their size or location, a significant minority of IHs are potentially problematic. Read More

Rom J Morphol Embryol 2018 ;59(3):949-953

"Victor Babeş" National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania;

Ionizing radiation was used in the past for treatment of several benign cutaneous conditions, and particularly hemangiomas. Even though radiotherapy was generally effective, it significantly augmented the risk for malignancies, resulting in a consequent heavy decline of its use for benign conditions. However, radiation-induced neoplasia is still encountered in adult patients irradiated during childhood or adolescence. Read More

J Stomatol Oral Maxillofac Surg 2018 Nov 29. Epub 2018 Nov 29.

University of Milan, San Paolo Hospital, Department of Maxillo-Facial Surgery, Via A. DiRudinì, 8, 20100, Milan, Italy.

Can J Ophthalmol 2018 Dec 3;53(6):e244-e246. Epub 2018 Apr 3.

Pusan National University School of Medicine, Yangsan, South Korea. Electronic address:

J Coll Physicians Surg Pak 2018 Dec;28(12):970-971

Department of Pathology, Khyber Medical College, Peshawar, Pakistan.

A five-day baby girl presented with a large mass involving the right upper and lower eyelid obstructing the visual axis completely. She was treated with intralesional triamcinolone acetonide injection under general anesthesia but no change in size of the tumor was observed. Oral beta blocker, propranolol, 1 mg/kg body weight, was given at three months. Read More

Australas J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.

Recently, several studies have reported their experience in using oral atenolol in patients with infantile haemangioma (IH), especially as an alternative to propranolol, but the efficacy and safety of oral atenolol has not been evaluated. We searched PubMed (Medline), Central, Embase, Web of Science and EBSCOhost (until May 2018) for the eligible studies reporting more than 10 IH patients who were treated with oral atenolol with detailed original data, including outcomes, regimens and adverse events (AEs). The data was standardised and analysed by using R software with meta-package. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13448

Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi "Bonino-Pulejo".

Rationale: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a cytosine, guanine, thymine (CTG) trinucleotide repeat expansion in the non-coding region of dystrophia myotonica protein kinase gene, causing a multisystem involvement. To date, few studies have been performed to evaluate skin features in DM1 patients, but none reported on the possible association between the disease and tongue hemangiomas.

Patients Concerns: We report a case of a 63-year-old woman affected by DM1 and presenting, at the intraoral examination, several swelling and buish lesions occurring on buccal and palatal mucosa, and in the anterior two-thirds and margins of the tongue. Read More

Acta Otorrinolaringol Esp 2018 Nov 26. Epub 2018 Nov 26.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Introduction And Objective: Oral benign neoplasms (OBNs) exhibit some features that can guide the professionals to the correct diagnosis and best treatment. Through retrospective studies, medical records can be reviewed to better describe a given population and, furthermore, help clinicians in routine practice. In this context, the objective of this paper was to analyze the cases of OBNs of an oral pathology referral department, from 2003 to 2017, in order to better understand their epidemiological and clinicopathological characteristics. Read More

Oral Radiol 2018 May 23. Epub 2018 May 23.

Department of Oral and Maxillofacial Radiology and Diagnosis, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi Ward, Yokohama, Kanagawa, 230-8501, Japan.

Objective: Vascular malformations occur more rarely in bones than in soft tissue, with 0.5-1.0% of all intraosseous tumors occurring in the mandible. Read More

Oral Radiol 2018 May 27;34(2):179-184. Epub 2017 Mar 27.

Department of Oral and Maxillofacial Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia.

The most conspicuous element of Gorham's disease is its radiographic features, wherein massive disappearance of the mandible is observed. We report a case of an adolescent boy with massive osteolysis of the mandible in whom the diagnosis of Gorham's disease was made. A 14-year-old boy was referred to the Department of Oral and Maxillofacial Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, for the management of a massive mandibular deformity. Read More

Oral Radiol 2018 Sep 4;34(3):224-228. Epub 2017 Sep 4.

Department of Radiology, The Nippon Dental University Niigata Hospital, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan.

Objectives: The aim of this study was to investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI) in oral and maxillofacial lesions, especially the utility of apparent diffusion coefficient (ADC) maps for differential diagnosis of these lesions.

Methods: Fifty-seven patients who underwent magnetic resonance imaging for diagnosis of oral and maxillofacial lesions were included in this prospective study. DWI was performed on a 1. Read More

J Exp Ther Oncol 2018 Nov;12(4):291-294

MBBS student, Hind Institute of Medical Sciences, Lucknow, U.P, India.

Objective: A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. Read More

J Craniofac Surg 2019 Jan;30(1):193-195

Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Kagawa.

Hemangiomas are benign vascular soft tissue tumors, which most frequently occur in the skin or subcutaneous tissue. Intramuscular hemangiomas typically occur in the trunk and extremities and less frequently in the head and neck. Among these, those occurring in the temporalis muscle are extremely rare. Read More

Arch Plast Surg 2018 Nov 15;45(6):517-524. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea.

Background: Infantile hemangioma (IH) is a common vascular tumor in pediatric patients, and is commonly treated with propranolol. We describe our experiences with dosage, response to treatment, and side effects in 23 IH patients treated with propranolol.

Methods: For this nonrandomized comparative cohort study, the authors enrolled 23 patients treated with propranolol. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. In this continuing medical education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities. Read More

J Oral Sci 2018 Dec 15;60(4):574-578. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry.

To better understand the clinical features of mass lesions of the tongue, we retrospectively evaluated frequency, recurrence rate, and complications in 296 patients who had undergone surgery for such lesions. The diagnoses were fibroma (43.6%), mucous cyst (14. Read More

JAMA Ophthalmol 2018 Oct 25. Epub 2018 Oct 25.

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Importance: Choroidal hemangiomas are defined by a thickened choroid owing to vessel overgrowth, which may increase the intraocular pressure and lead to glaucoma. Choroidal hemangioma and glaucoma often co-occur in patients with Sturge-Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations.

Objective: To determine whether the mutation found in most capillary malformations, GNAQ R183Q (c. Read More

Eur J Pediatr 2019 Jan 12;178(1):1-6. Epub 2018 Nov 12.

Department of Pediatric Surgery, Vascular Anomalies Center, Autonoma University of Madrid, Madrid, Spain.

Propranolol has changed the management of infantile hemangiomas (IHs). We summarize the evolution of surgical treatment for IH at La Paz Children's Hospital (Madrid) in the era of propranolol, with a focus on hepatic IHs.Retrospectively, we compared surgical treatment of IHs in children referred during the periods 2004-2009 and 2009-2014. Read More

Br J Dermatol 2018 Nov 10. Epub 2018 Nov 10.

Cochrane Ecuador, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Quito, Ecuador.

Background: Infantile haemangiomas (IH) are soft swellings of the skin that occur in 3-10% of infants. When haemangiomas occur in high-risk areas or when complications develop, active intervention is necessary.

Objective: To update a Cochrane Review assessing the interventions for the management of IH in children. Read More

Bol Med Hosp Infant Mex 2018 ;75(6):377-382

Departamento de Otorrinolaringología Pediátrica. Hospital Infantil de México Federico Gómez, Ciudad de México, México.

Background: Airway hemangiomas are congenital neoplasms of low incidence. Its clinical presentation consists of obstruction of the upper airway with progressive dyspnea and stridor and the life of the patient at risk. Infantile hemangiomas have an incidence at birth of 2%, increasing to 9% at 12 months of life. Read More

J Surg Case Rep 2018 Oct 23;2018(10):rjy283. Epub 2018 Oct 23.

Department of Pathology, Grande International Hospital, Dhapasi, Kathmandu, Nepal.

Hemangiomas are benign tumors comprising of ectatic blood vessels. Although common in the head and neck region, those occurring within the oral cavity and tongue are exceedingly rare. We report a 5-year-old boy with a swelling over the anterior third of tongue post failed conservative therapy eventually treated with surgical excision and confirmed histologically as a cavernous hemangioma probably first of its kind reported from Nepal. Read More

J Cell Biochem 2018 Oct 28. Epub 2018 Oct 28.

Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Infantile hemangioma (IH) is a common benign tumor. Human umbilical vein endothelial cells (HUVECs) have the potential of stem cells, which has been widely used in vascular endothelial cell experiments. Oral propranolol was first reported to treat hemangioma in 2008. Read More

J Oral Facial Pain Headache Fall 2018;32(4):e45-e48

Hemangiomas are benign vasoformative neoplasms or developmental conditions of endothelial origin. Synovial hemangiomas arise from a synovial lined surface within a joint space. This report describes a case of synovial hemangioma of the left temporomandibular joint (TMJ) in a 65-year-old male patient. Read More

Arch Pediatr 2018 Nov 22;25(8):449-451. Epub 2018 Oct 22.

Department of dermatology's diseases, CHU Ibn Rochd, 20050 Casablanca, Morocco; Faculty of medicine and pharmacy, University Hassan II, Casablanca, Morocco.

Infantile hemangiomas are the most common childhood vascular tumors. Propranolol is a β-adrenergic blocker that has proven effective in the treatment of this tumor. Numerous studies around the world have been published, describing satisfactory responses in pediatric populations with a higher cure rate and fewer adverse effects than when using corticosteroids. Read More

In Vivo 2018 Nov-Dec;32(6):1323-1331

Department of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany

Background/aim: Vascular anomalies encompass different vascular malformations [arteriovenous (AVM), lymphatic (LM), venous lymphatic (VLM), venous (VM)] and vascular tumors such as hemangiomas (HA). The pathogenesis of vascular anomalies is still poorly understood. Viral infection was speculated as a possible underlying cause. Read More

Pediatr Dermatol 2019 Jan 15;36(1):e41-e43. Epub 2018 Oct 15.

Dermatopathology Division, Department of Pathology and Laboratory Medicine, Sylvester Comprehensive Cancer Center and Miller School of Medicine, University of Miami, Miami, Florida, USA.

Disseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT-1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. Read More

Mol Imaging Radionucl Ther 2018 Oct;27(3):99-106

Ege University Faculty of Medicine, Department of Nuclear Medicine, İzmir, Turkey

Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging. Read More

J Cancer Res Clin Oncol 2018 Dec 6;144(12):2475-2484. Epub 2018 Oct 6.

Department of Vascular and Interventional Radiology, Chengdu Women and Children's Central Hospital, Chengdu, 610031, China.

Purpose: We sought to characterize the clinical features and management of patients diagnosed as Kaposiform hemangioendothelioma (KHE) without cutaneous involvement.

Methods: The electronic patient chats at six Triple A hospitals in China were searched to find all patient diagnoses with KHE without cutaneous involvement.

Results: Of 30 patients (mean age at diagnosis, 55. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Jan 9;127(1):77-84. Epub 2018 Sep 9.

Division of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, Japan. Electronic address:

Objective: The aim of this study was to evaluate the characteristics of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values of ranulas. In addition, to elucidate DWI findings and ADC values of other representative masses in and around the floor of the mouth.

Study Design: DWI findings and ADC values in 35 patients with ranulas and 33 patients with other masses were retrospectively reviewed with a central focus on cystic masses or lesions that may have cyst-like components in and around the floor of the mouth based on the diagnosis of each respective disease. Read More

Int J Oral Maxillofac Surg 2019 Feb 2;48(2):181-186. Epub 2018 Oct 2.

Hemangioma Specialized Department of Linyi Tumour Hospital, Linyi, Shandong 276001, People's Republic of China. Electronic address:

Treatment of arteriovenous malformations (AVMs) should be individualized based on the imaging findings. A total of 117 AVM cases were categorized into three types based on the angio-architectural characteristics: Type I (n=14, no draining vein or diameter of the draining vein <2mm); Type II (n=64, draining vein diameter 2-6mm); and Type III (n=39, draining vein diameter >6mm). Subjects were randomly allocated to one of two treatment groups: Group A (n=59) received multipoint percutaneous ethanol injection (MPEI), while Group B (n=58) received super-selective angiograms followed by embolization with gelfoam (EFAG) plus MPEI. Read More

J Pediatr Surg 2018 Sep 5. Epub 2018 Sep 5.

Department of Pediatric Thoracic and General Surgery, Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA. Electronic address:

Purpose: There has been a paradigm shift from corticosteroid to propranolol treatment for infantile hemangiomas (IHs), with surgical resection reserved for complicated or persistent IHs. The purpose of this study was to determine if propranolol treatment was associated with decreased utilization of surgical resection compared to corticosteroids.

Methods: A single center retrospective chart review of all corticosteroid or propranolol treated IHs between 2005 and 2014 was performed. Read More

Pediatr Clin North Am 2018 10;65(5):1033-1050

Department of Otolaryngology, University of Tennessee Health Science Center, 910 Madison Avenue, Suite 420, Memphis, TN 38163, USA; Department of Pediatric Otolaryngology, LeBonheur Children's Hospital, 848 Adams Avenue, Memphis, TN 38103, USA; Department of Otolaryngology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

Oral lesions in children encompass a wide range of etiologies, including idiopathic entities as well as those related to an underlying systemic illness. In addition, oral masses include benign entities harboring locally destructive behavior and even malignancies in rare cases. Thorough patient history and detailed and efficient physical examination are critical for determining which lesions can be closely observed versus those require further diagnostic work-up. Read More

Orv Hetil 2018 Sep;159(37):1516-1524

Fogorvostudományi Kar, Szájsebészeti Tanszék, Szegedi Tudományegyetem Szeged.

Introduction: In a clinicopathological retrospective epidemiological study we investigated benign tumors and tumor-like lesions located in the orofacial region, diagnosed at the Universiy of Szeged, Department of Oral Medicine.

Method: During a 54-year period (1960-2014), 14 661 biopsies were taken. The included subjects were 7491 patients diagnosed with benign tumors and tumor-like lesions. Read More

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):203-205. Epub 2017 Jul 1.

Department of Oral Pathology, Government Dental College and Hospital, St. George Hospital Campus, Near Chhatrapati Shivaji Terminus Area, Fort, Mumbai, Maharashtra 400001, India.

Radiolucent lesions of Temporomandibular Joint (TMJ) represent a diagnostic challenge and a treatment conundrum. Biopsy of the lesions is technically difficult owing to their complex anatomy. The Differential Diagnosis (DD) includes a wide array of lesions including Simple Bone Cyst, Ameloblastoma, Central Giant Cell Granuloma, Hemangioma, Osteoblastoma, Osteochondroma, Chondroblastoma, Chondrosarcoma, Neurofibroma and metastatic malignant lesions though none has a specific predilection for TMJ. Read More

Tanaffos 2018 Jan;17(1):57-61

Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sturge-Weber syndrome (SWS) is a neurocutaneous disorder, characterized by leptomeningeal angiomas involving the oral cavity, trachea, larynx, and face. Herein, we present a case of vitrectomy in a seven-year-old boy with SWS. The patient showed hemangioma on the left side of his face, as well as mental retardation and epilepsy. Read More

J Pediatr Adolesc Gynecol 2019 Feb 11;32(1):80-82. Epub 2018 Aug 11.

Department of Obstetrics and Gynecology, Stanford University, Stanford, California.

Background: The differential diagnosis for pediatric prepubertal vaginal bleeding is wide. Rare etiologies include vascular malformations and tumors, such as infantile hemangiomas (IHs), which validate the usefulness of exam under anesthesia, vaginoscopy, and tissue diagnosis.

Case: We report a case of an IH in a 6-year-old girl causing vaginal bleeding requiring transfusion. Read More

Pediatrics 2018 Sep 6;142(3). Epub 2018 Aug 6.

Pierre Fabre Dermatologie, Lavaur, France.

Background And Objectives: There is no consensus on optimal treatment duration for propranolol in infantile hemangioma (IH). We evaluated the efficacy and safety of oral propranolol solution administered for a minimum of 6 months up to a maximum of 12 months of age in high-risk IH.

Methods: This single-arm, open-label, phase 3 study was conducted in patients aged 35 to 150 days with high-risk IH in 10 hospitals between 2015 and 2017. Read More

Ophthalmology 2019 Jan 1;126(1):146-155. Epub 2018 Aug 1.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.

Purpose: To review the published literature assessing the efficacy of β-blockers for the treatment of periocular hemangioma in infants.

Methods: Literature searches were conducted in May 2018 in PubMed with no date restrictions and limited to studies published in English and in the Cochrane Library database without any restrictions. The combined searches yielded 437 citations. Read More

Clin Nucl Med 2018 Oct;43(10):e360-e362

From the Departments of Nuclear Medicine.

A 43-year-old woman with papillary thyroid cancer prepared for I ablation after total thyroidectomy. With a history of type 2 diabetes for 10 years, she recently presented with periodontitis, candidiasis, and mouth dryness. TcO4 scintigraphy was ordered to evaluate function of the salivary glands. Read More

J Craniofac Surg 2018 Oct;29(7):1876-1879

Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University.

Infantile hemangioma can grow dramatically or typically locate on the face, which may lead to functional impairment, cosmetically disfiguring and exhibiting complications such as ulceration, bleeding, or infection. Early intervention is necessary. In this study, the authors chose individual treatment for different patients. Read More

J Dermatol 2018 Oct 27;45(10):1199-1202. Epub 2018 Jul 27.

Department of Pediatrics, Showa General Hospital, Tokyo, Japan.

Infantile hemangiomas grow rapidly during infancy followed by gradual involution. After involution, residual lesions sometimes remain. Despite the prognosis for eventual involution, infantile hemangiomas often cause great psychosocial morbidity that affects patients and their parents. Read More