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    Vascular Anomalies: From a Clinicohistologic to a Genetic Framework.
    Plast Reconstr Surg 2018 May;141(5):709e-717e
    Boston, Mass. From the Department of Plastic and Oral Surgery, Children's Hospital Boston, Harvard Medical School.
    Background: Vascular anomalies currently are classified according to their clinical and histological characteristics. Recent advances in molecular genetics have enabled the identification of somatic mutations in most types of vascular anomalies. The purpose of this study was to collate information regarding the genetic basis of vascular anomalies. Read More

    Effects of Propranolol on Neurodevelopmental Outcomes in Patients with Infantile Hemangioma: A Case-Control Study.
    Biomed Res Int 2018 25;2018:5821369. Epub 2018 Feb 25.
    Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
    Background: The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs).

    Methods: Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Read More

    Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review.
    J Cutan Med Surg 2018 Apr 1:1203475418770570. Epub 2018 Apr 1.
    5 Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
    Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Read More

    Interventions for infantile haemangiomas of the skin.
    Cochrane Database Syst Rev 2018 Apr 18;4:CD006545. Epub 2018 Apr 18.
    Paediatric Dermatology Department, Hospital San Jose-Fundacion Universitaria de Ciencias de la Salud, Carrera 19, No. 8A-32, Bogota, Colombia.
    Background: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. Read More

    Diffusion-Weighted Imaging in the Oral and Maxillofacial Region: Usefulness of Apparent Diffusion Coefficient Maps and Maximum Intensity Projection for Characterization of Normal Structures and Lesions.
    Pol J Radiol 2017 20;82:571-577. Epub 2017 Oct 20.
    Department of Radiology, The Nippon Dental University Niigata Hospital, Niigata, Japan.
    Background: The aim of this study was to investigate diffusion-weighted imaging (DWI) in the oral and maxillofacial region, with a special focus on the usefulness of apparent diffusion coefficient (ADC) maps and maximum intensity projection (MIP) for characterization of normal structures and lesions.

    Material/methods: Thirty-five patients who underwent magnetic resonance imaging (MRI) for diagnosis of oral and maxillofacial lesions were included in this prospective study. DWI was performed on a 1. Read More

    The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas.
    World J Plast Surg 2018 Jan;7(1):16-24
    Sir Syed Nagar, JNMCH, AMU, Aligarh, India.
    Background: Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas.

    Methods: In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. Read More

    Cleft Palate Repair Using Single Flap Palatoplasty in Patient With Associated Palatal Hemangioma.
    J Craniofac Surg 2018 Mar 30. Epub 2018 Mar 30.
    Department of Plastic Reconstructive and Aesthetic Surgery.
    Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusual for hemangiomas, which are already rarely seen isolated on the palate, to coexist with cleft palate as in the authors' patient. Four months old baby was admitted with isolated Veau 2 cleft palate and a red-purple colored raised lesion involving almost the whole right side of the hard palate. Read More

    Thirty-two Japanese cases of infantile hemangiomas treated with oral propranolol.
    J Dermatol 2018 Mar 31. Epub 2018 Mar 31.
    Department of Pediatrics, Showa General Hospital, Tokyo, Japan.
    Infantile hemangiomas undergo rapid growth during early infancy followed by gradual involution. Infantile hemangiomas sometimes impair vital functions or cause disfigurement. Thirty-two Japanese patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received oral propranolol on an outpatient basis. Read More

    Selected presentations of lip enlargement: clinical manifestation and differentiation.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):18-25. Epub 2018 Feb 20.
    Department of Oral Surgery, Poznan University of Medical Sciences, Poznan, Poland.
    Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. Read More

    Analysis of Follicle-Stimulating Hormone Receptor in Infantile Hemangioma.
    Ann Plast Surg 2018 Apr;80(4 Suppl 4):S211-S213
    From the Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, Boston, MA.
    Introduction: The life cycle of infantile hemangioma (IH) and secretion of follicle-stimulating hormone (FSH) are identical. We previously have shown that IH contains the FSH receptor (FSHR). The purpose of this study was to identify which cell type(s) in IH expresses FSHR. Read More

    Topical propranolol for infantile haemangiomas: A systematic review.
    J Eur Acad Dermatol Venereol 2018 Mar 23. Epub 2018 Mar 23.
    ENT Department, University Hospital of Wales, Cardiff, Wales.
    Infantile haemangiomas are the most common tumour of infancy. Whilst the majority are left untreated to involute spontaneously, residual skin changes commonly occur, particularly in superficial haemangiomas. The current first line treatment for problematic lesions is oral propranolol, however due to the risk of systemic adverse effects, the use of off-label topical preparations has recently been investigated. Read More

    Resolution of consumptive hypothyroidism secondary to infantile hepatic hemangiomatosis with combination propranolol and levothyroxine.
    J Clin Res Pediatr Endocrinol 2018 Feb 28. Epub 2018 Feb 28.
    Infantile hepatic hemangiomas (IHH), particularly of the diffuse subtype, can in severe cases be associated with hepatic and cardiac failure, compartment syndrome, and consumptive hypothyroidism. Early recognition and treatment of these pathologies is paramount in order to minimise the risk of longterm sequelae. We report an interesting case of a female infant who presented with systemic compromise, in the absence of large or obvious cutaneous infantile hemangiomas (IH). Read More

    Spontaneous Rupture of a Hepatic Adenoma: Diagnostic Nuances and the Necessity of Followup.
    Cureus 2017 Dec 20;9(12):e1975. Epub 2017 Dec 20.
    Department of Emergency Medicine, University of Arizona.
    We present the case of a young female on oral contraceptives (OCs) who was diagnosed with focal nodular hyperplasia (FNH) and remained on oral contraceptives. Months later, the patient presented with acute abdominal pain and intratumoral hemorrhage in the liver. The patient was taken to the operating room (OR) and was diagnosed with a ruptured hepatic adenoma (HA). Read More

    Carcinogenicity of quinoline by drinking-water administration in rats and mice.
    J Toxicol Sci 2018 ;43(2):113-127
    The carcinogenicity of quinoline was examined by administrating quinoline in the drinking water to groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of each sex. In rats, the doses of quinoline were 0, 200, 400, and 800 ppm for males and 0, 150, 300, and 600 ppm for females. In male rats, administration of quinoline was terminated at week 96 due to high mortality caused by tumors. Read More

    A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis.
    Am J Med Genet A 2018 Apr 13;176(4):1015-1022. Epub 2018 Feb 13.
    Center for Craniofacial Research, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas.
    Tooth development is regulated by multiple genetic pathways, which ultimately drive the complex interactions between the oral epithelium and mesenchyme. Disruptions at any time point during this process may lead to failure of tooth development, also known as tooth agenesis (TA). TA is a common craniofacial abnormality in humans and represents the failure to develop one or more permanent teeth. Read More

    Topical timolol for an iris hemangioma.
    J AAPOS 2018 Apr 20;22(2):156-158. Epub 2018 Mar 20.
    University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; Pediatric Ophthalmology, Children's Mercy Hospital, Kansas City, Missouri. Electronic address:
    Extraocular infantile hemangiomas have been shown to respond to oral and topical beta blockers, while there is little literature regarding the management of intraocular infantile hemangiomas with beta blockers. This case report discusses the management of an iris hemangioma with topical timolol, a treatment previously unreported in the literature. Read More

    Factors associated with delayed referral for infantile hemangioma necessitating propranolol.
    J Eur Acad Dermatol Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Reference Centre for Rare Skin Diseases, Dermatology Department, CHU Larrey, Paul Sabatier University, Toulouse, France.
    Background: Oral propranolol is the gold standard to treat infantile hemangiomas. There is better efficacy and a lower risk of sequelae if therapy is started before the end of the growth phase, but most children are referred too late. Herein, we report the first study to investigate the delay and its associated factors when referring infants with infantile hemangiomas that need propranolol therapy. Read More

    Vascular Anomalies of the Head and Neck Region.
    J Maxillofac Oral Surg 2018 Mar 5;17(1):1-12. Epub 2018 Jan 5.
    Maxillofacial Surgery Department, Bangalore Institute of Dental Sciences, Bangalore, India.
    Vascular anomalies of the head and neck region are a complex group of lesions that challenge the head and neck physicians. From the very understanding of the difference between its two distinct forms, hemangiomas and vascular malformations to its management remain confusing. The review of this anomaly attempts at comprehensively understanding the disease. Read More

    Paediatric oral pathology in Thailand: a 15-year retrospective review from a medical teaching hospital.
    Int Dent J 2018 Jan 28. Epub 2018 Jan 28.
    Department of Pathology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
    Objectives: To determine whether the spectrum of oral pathology in children seen at a medical institution differs from studies derived from dental facilities.

    Methods: Oral biopsy records from paediatric patients (<16 years of age) were retrieved from the pathology archives at Chulalongkorn University Hospital over a period of 15 years. Lesions were categorised as inflammatory/reactive, tumour/tumour-like or cystic. Read More

    Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

    A case series of intraosseous hemangioma of the jaws: Various presentations of a rare entity.
    J Clin Exp Dent 2017 Nov 1;9(11):e1366-e1370. Epub 2017 Nov 1.
    BDS MSc, Professor, 1959 NE Pacific St, Department of Oral & Maxillofacial Surgery, University of Washington School of Dentistry, Seattle, Washington 98195-7133, USA.
    Background: Hemangiomas of the soft tissue are common in the head and neck area, especially in the tongue and in children under ten years of age. Intraosseous hemangiomas of the mandible and maxilla (IHM), on the other hand, are exceedingly rare and are not well characterized. This study presents six IHM cases focusing on the clinical, radiographic, and histologic characteristics. Read More

    Effect of oral propranolol on periocular Capillary Hemangiomas of Infancy.
    Pediatr Neonatol 2017 Dec 6. Epub 2017 Dec 6.
    Dept of Pediatric Ophthalmology & Strabismus, Sankara Nethralaya, Medical Research Foundation, Chennai, India.
    Background: To assess the safety and efficacy of oral propranolol in the management of periocular Capillary Hemangiomas of Infancy (CHI).

    Methods: Medical records of 21 infants diagnosed with periocular capillary hemangioma during a period of 5 years from 2009 to 2014 were retrospectively reviewed. The data collected included demographic details, clinical features and details of imaging studies and response to the therapy. Read More

    Huge fetal hepatic Hemangioma: prenatal diagnosis on ultrasound and prognosis.
    BMC Pregnancy Childbirth 2018 01 2;18(1). Epub 2018 Jan 2.
    Department of Ultrasound, GZ Women & Children Medical Centre, Jinsui Road 9, Guangzhou, 510623, China.
    Background: Although huge fetal hepatic hemangiomas are rare, they can cause fatal complications. The purpose of this study is to describe the imaging features and prognosis of these tumors.

    Methods: Imaging data were collected for 6 patients with huge fetal hepatic hemangiomas treated at our hospital. Read More

    Combined approach to management of periocular arteriovenous malformation by interventional radiology and surgical excision.
    Indian J Ophthalmol 2018 01;66(1):151-154
    Department of Interventional Radiology, Apollo Specialty Hospitals, Chennai, Tamil Nadu, India.
    Periorbital arteriovenous malformations (AVMs) are congenital lesions that may cause significant morbidity such as amblyopia, cosmetic disfigurement, or chronic pain. Due to the rarity of these lesions, they are frequently misdiagnosed and treated inappropriately. We managed a 6-year-old girl with preseptal AVM by endovascular embolization followed by complete surgical excision after 2 days. Read More

    Unusual Case of Acquired Capillary Hemangioma of the Eyelid in an Adult.
    Ann Maxillofac Surg 2017 Jul-Dec;7(2):308-311
    Department of Plastic Surgery, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India.
    Acquired capillary hemangioma of the eyelid is very uncommon in adults. To our knowledge, only eight such cases have been reported in the literature till date. We report the case of a 25-year-old female with acquired capillary hemangioma of the left lower eyelid treated by cutting diathermy followed by reconstruction of the cutaneous and cartilaginous defect. Read More

    Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas.
    Clin Ophthalmol 2017 8;11:2177-2181. Epub 2017 Dec 8.
    Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
    Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma.

    Patients And Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Read More

    [Treatment analyses of 143 patients with maxillofacial and cervical venous malformations involved in isthmus faucium area].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;52(12):909-914
    Special Department of Hemangiomas, Linyi Tumor Hospital, Linyi 276001, Shandong Province, China.
    To analyze the clinical data and summarize therapeutic experiences of cervicofacial venous malformations involving isthmus faucium area. Clinical records from 143 patients with venous malformations involving isthmus faucium area treated at our hospital between January 2012 and January 2016 were reviewed. There were 70 males and 73 females. Read More

    [What's new in pediatric dermatology?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS29-IVS39
    Centre de référence des maladies rares de la peau et des muqueuses d'origine génétique, service de dermatologie, hôpital Archet 2, CHU de Nice, France. Electronic address:
    The year 2017 in pediatric dermatology was marked by several consensus recommendations and meta analyzes on childhood psoriasis, atopic dermatitis or PHACE syndrome, case series on the role of anti-JAK treatment in adolescent with alopecia areata, sirolimus for vascular malformations, ivermectine for rosacea, inhibitors of MEK for type 1 neurofibromatosis or on the side effects of the oral isotretinoin for acne or propranolol for immature hemangioma. Only few randomized controlled studies have been published on the interest of adalimumab in the treatment of psoriasis or topical sirolimus for angiofibroma in tuberous sclerosis complex for example. There were also clinical articles on various affections such as the sign of the scalp hair collar sign, childhood prurigo, ichthyosis, atopic dermatitis, warts or Zika virus infection. Read More

    Congenital Vascular Tumors.
    Otolaryngol Clin North Am 2018 Feb;51(1):89-97
    Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue Boston, MA, 02115, USA. Electronic address:
    Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. These lesions present during infancy or childhood, may affect any location, and exhibit postnatal growth. Local complications include bleeding, tissue destruction, and pain whereas systemic sequelae include thrombocytopenia, congestive heart failure, and death. Read More

    Infantile Hemangiomas in the Head and Neck Region.
    Otolaryngol Clin North Am 2018 Feb;51(1):77-87
    Division of Hematology, Vascular Anomalies Center, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Oncology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Division of Hematology, Hemangioma and Vascular Malformation Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Infantile hemangiomas (IHs) are benign vascular tumors of infancy most common in the region of the head and neck. Infantile hemangiomas are common; but they are extremely heterogeneous and cause a range of complications depending on their morphology, size, or location. Medical interventions for high-risk patients include topical and systemic therapies, including oral propranolol, which has revolutionized the management of IHs over the past recent years. Read More

    Significant inhibition of infantile hemangioma growth by sustained delivery of urea from liposomes-in-microspheres.
    Oncol Rep 2018 Jan 20;39(1):109-118. Epub 2017 Nov 20.
    Department of Hemangioma and Vascular Malformation, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China.
    Infantile hemangioma (IH) is a benign pediatric tumor, and rapid growth of IH can result in serious morbidity and even mortality. Only one drug Hemangeol™ (propranolol hydrochloride oral solution) has been approved for the treatment of IH, whereas patients suffer from its adverse effects and high frequency of administration. We have used urea, an organic compound and a normal body metabolite, in the treatment of IH for 20 years, and demonstrated that urea is an effective and well-tolerated treatment for IH. Read More

    Role of imaging in the diagnosis of parotid infantile hemangiomas.
    Int J Pediatr Otorhinolaryngol 2017 Nov 4;102:61-66. Epub 2017 Sep 4.
    Vascular Anomalies Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Division of Vascular and Interventional Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:
    Objectives: To review the clinical presentation, imaging and follow-up of parotid infantile hemangiomas (IH).

    Methods: Over a 15-year period, all patients with a clinical diagnosis of parotid IH were evaluated. Imaging was available in 35. Read More

    Clinical and Radiological Evaluation of Periocular Infantile Hemangioma Treated With Oral Propranolol: A Case Series.
    Am J Ophthalmol 2018 Jan 15;185:48-55. Epub 2017 Nov 15.
    Department of Ophthalmology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
    Purpose: To evaluate the efficacy of propranolol (3 mg/kg/day) in the treatment of periocular infantile hemangioma (IH) based on clinical and radiological findings.

    Design: Prospective interventional case series.

    Methods: Study of previously untreated infants with IH conducted at the ophthalmology outpatient service of HC-FMUSP (Brazil). Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    Intraosseous Hemangioma of the Frontal Bone. Report of a Case and Review of the Literature.
    J Oral Maxillofac Surg 2018 Apr 23;76(4):799-805. Epub 2017 Sep 23.
    Program Director, Associate Professor, and Chief of Oral and Maxillofacial Surgery, Harborview Medical Center, Seattle, WA. Electronic address:
    Intraosseous hemangiomas of the maxillofacial region are rare lesions that constitute less than 1% of all osseous tumors. A review of the literature on intraosseous hemangiomas of the skull and facial bones showed a limited number of publications, much of which were largely limited to case reports. This case report summarizes the workup and surgical treatment of a 39-year-old woman with an intraosseous hemangioma of the left frontal bone. Read More

    Combined Oral and Topical Beta Blockers for the Treatment of Early Proliferative Superficial Periocular Infantile Capillary Hemangioma.
    J Pediatr Ophthalmol Strabismus 2018 Jan 9;55(1):37-42. Epub 2017 Oct 9.
    Purpose: To evaluate the safety and efficacy of combined oral and topical beta blockers for the treatment of superficial periocular infantile hemangioma at the early proliferative stage.

    Methods: This was a randomized, controlled comparison trial involving 25 patients. Patients were randomly enrolled into two groups: the topical and systemic treatment and systemic treatment only groups. Read More

    A 24-Week Treatment of Pediatric Hemangioma with Oral Propranolol.
    Iran J Pharm Res 2017 ;16(2):811-816
    Cancer Research Center and Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran.
    Hemangioma is a benign vascular tumor that shouldbe treated in problematic situations.Propranolol efficacy, target dose, range of age, duration of treatment and complications arenot conclusive for treatment of pediatric hemangioma. Our goal was to study efficacy and safety of propranolol for hemangioma treating in children. Read More

    Propranolol Treatment of Vascular Anomalies Other Than Infantile Hemangioma.
    J Craniofac Surg 2017 Nov;28(8):2001-2003
    Department of Plastic and Oral Surgery Children's Hospital Boston Harvard Medical School Boston, MA.
    Background: Oral propranolol has become first-line intervention for problematic infantile hemangioma (IH) that is not amenable to topical or intralesional therapies. Consensus data supporting its efficacy for other vascular anomalies does not exist. The purpose of this study was to determine the frequency and causes of propranolol use for vascular lesions other than IH. Read More

    Cavernous lymphangioma of the tongue in an adult: a case report.
    J Istanb Univ Fac Dent 2017 3;51(2):49-53. Epub 2017 Apr 3.
    Department of Oral and Maxillofacial Surgery Faculty of Dentistry Istanbul University Turkey.
    Lymphangioma is a benign hamartomatous lesion caused by congenital malformation of the lymphatic system. This benign tumor is detected most commonly at birth or in early childhood but rarely in adults. On clinical examination, most lymphangiomas contain clear lymph fluid, but some may present as transparent vesicles containing red blood cells due to hemorrhage. Read More

    Inhibition of hemangioma growth using polymer-lipid hybrid nanoparticles for delivery of rapamycin.
    Biomed Pharmacother 2017 Nov 10;95:875-884. Epub 2017 Sep 10.
    Department of Vascular Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefangdadao Road, Wuhan 430022, Hubei, China. Electronic address:
    Although infantile hemangiomas is benign, its rapid growth may induce serious complications. However, only one drug Hemangeol™ has been approved by US Food and Drug Administration (FDA) to treat infantile hemangiomas. Thus it is necessary to develop novel alternative drugs to treat infantile hemangiomas. Read More

    Intramuscular hemangioma in buccal cheek: a case report.
    J Korean Assoc Oral Maxillofac Surg 2017 Aug 24;43(4):262-266. Epub 2017 Aug 24.
    Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea.
    Hemangioma is the most common benign tumor of a vascular origin, and is characterized by the abnormal proliferation of blood vessels. Intramuscular hemangioma (IMH) usually involves the skeletal muscles of the trunk or limbs, but rarely occurs in the head and neck region. This case report presents a patient with IMH showing multiple phleboliths in the buccal cheek. Read More

    Survivin: A novel marker and potential therapeutic target for human angiosarcoma.
    Cancer Sci 2017 Nov 15;108(11):2295-2305. Epub 2017 Sep 15.
    Division of Cancer Biology, National Cancer Center Research Institute, Tokyo, Japan.
    Human angiosarcoma is a rare malignant vascular tumor associated with extremely poor clinical outcome and generally arising in skin of the head and neck region. However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma. To investigate the mechanisms of angiosarcoma progression, we collected 85 cases of human angiosarcoma specimens with clinical records and analyzed ISO-HAS-B patient-derived angiosarcoma cells. Read More

    Prevalence and pattern of lobular capillary hemangioma in Eastern Madhya Pradesh, India: A clinicopathological analysis.
    Indian J Dent Res 2017 Jul-Aug;28(4):424-428
    Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
    Background: Lobular capillary hemangioma is a common benign vascular tumor seen in the oral cavity. It occurs in response to various stimuli such as low-grade local irritation, traumatic insult, and hormonal factors or as a response to a wide variety of drugs.

    Materials And Methods: All patients presenting to the Department of Dentistry, Shyam Shah Medical College, Rewa, Madhya Pradesh during July 2014 to June 2016, who were diagnosed by histopathologic confirmation as oral lobular capillary hemangioma (OLCH), were evaluated for the area involved, clinicopathologic presentation, demographic features, and treatment. Read More

    Hepatic Adenoma - A Case Report.
    S D Med 2017 03;70(3):105-107
    University of South Dakota Sanford School of Medicine.
    Although liver lesions in the young population are relatively rare, clinicians can benefit from being familiar with a subset of common benign liver lesions which include hepatic adenoma, hepatic hemangioma, and focal nodular hyperplasia. This a case report of a 25-year-old Jehovah's Witness female on chronic oral contraception for polycystic ovarian syndrome who presented with progressive right upper quadrant abdominal pain. Ultrasound and MRI findings were consistent with hepatic adenoma. Read More

    Study of Cognitive Function in Children Treated with Propranolol for Infantile Hemangioma.
    Pediatr Dermatol 2017 Sep 14;34(5):554-558. Epub 2017 Aug 14.
    Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain.
    Background: Oral propranolol is considered the first choice for the treatment of infantile hemangiomas (IHs). There is a concern that administering propranolol in newborns and infants could induce adverse effects in learning and memory processes in the long term. The purpose of this study was to assess cognitive and memory functions in children who had been treated with propranolol for IH during their infancy. Read More

    Simple Preparation of Timolol 0.5% Gel from Eye Drop Solution for Superficial Infantile Hemangiomas.
    Int J Pharm Compd 2017 Jul-Aug;21(4):282-289
    National Skin Centre Pte. Ltd., Singapore.
    The discovery of beta-adrenergic blocker effects on infantile hemangiomas has affected the choice of treatment in recent years. Oral propranolol is effective in treating infantile hemangiomas, but the risk of systemic side effects remains a concern. Data from literature review reported positive clinical outcomes with no major adverse effects observed in children using topical beta-blocker such as timolol maleate. Read More

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