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    When to stop propranolol for infantile hemangioma.
    Sci Rep 2017 Feb 22;7:43292. Epub 2017 Feb 22.
    From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
    There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    Zygomatic Intraosseous Hemangioma: Case Report and Literature Review.
    Craniomaxillofac Trauma Reconstr 2017 Mar 4;10(1):1-10. Epub 2016 Nov 4.
    Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Intraosseous hemangiomas are uncommon intrabony lesions, representing approximately 0.5 to 1% of all intraosseous tumors. Their description varies from "benign vasoformative neoplasms" to true hamartomatous proliferations of endothelial cells forming a vascular network with intermixed fibrous connective tissue stroma. Read More

    Sinonasal Hemangioma: Diagnosis, Treatment, and Follow-Up of 37 Patients at a Single Center.
    J Oral Maxillofac Surg 2017 Jan 5. Epub 2017 Jan 5.
    Professor, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University, Jeonju, Korea; and Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. Electronic address:
    Purpose: Hemangioma is a common benign vascular lesion of the head and neck region. It rarely involves the mucous membranes of the nasal cavity and paranasal sinuses. It should be added to the differential diagnosis of nasal cavity masses when the presenting symptoms are epistaxis or nasal obstruction. Read More

    Intraosseous Cavernous Hemangioma in the Mandible: A Case Report.
    J Clin Exp Dent 2017 Jan 1;9(1):e153-e156. Epub 2017 Jan 1.
    MD, Specialist Doctor of Medicine; Ministry of Health Turkish Public Hospitals Institution Association of Antalya Public Hospitals Serik State Hospital, Department of Pathology, Antalya/Turkey.
    Intraosseous vascular lesions are rare conditions. They are most commonly seen in the vertebral column and skull; nevertheless, the mandible is a quite rare location. In this report, we present a case of intraosseous cavernous hemangioma in the mandible and discuss the clinical and radiological features. Read More

    Benign vascular lesions of the lips: Diagnostic approach.
    J Cutan Pathol 2017 Jan 23. Epub 2017 Jan 23.
    School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
    Background: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In this study, vascular lesions occurring in the lips were retrieved from an Oral Pathology Service.

    Methods: Among 5600 biopsies, 131 cases were found. Read More

    Infantile haemangioma.
    Lancet 2017 Jan 12. Epub 2017 Jan 12.
    Departments of Paediatrics and Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.
    With a prevalence of 4·5%, infantile haemangiomas are the most common benign tumours of infancy, arising in the first few weeks of life and exhibiting a characteristic sequence of growth and spontaneous involution. Most infantile haemangiomas do not require therapy. However, to identify at-risk haemangiomas, close follow-up is crucial in the first weeks of life; 80% of all haemangiomas reach their final size by 3 months of age. Read More

    Infantile Intraosseous Maxillary Hemangioma.
    Indian Pediatr 2016 Dec;53(12):1103-1104
    Departments of Otorhinolaryngology and Head and Neck Surgery, and *Pathology, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India. Correspondence to: Dr Divya Gupta, Department of Otolaryngology and Head and Neck Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.
    Background: Primary osseous hemangiomas of the facial skeleton mimic malignancy. Their location in maxillary sinus, especially in infants is extremely rare.

    Case Characteristics: 1- month-old full term boy with maxillary swelling. Read More

    Oral propranolol for infantile hemangiomas: a prospective study on the role of 48-hour Holter monitoring in additional safety assessment.
    J Dermatolog Treat 2017 Jan 11:1-8. Epub 2017 Jan 11.
    a Department for Cardiology , University Children's Hospital Tirsova , Belgrade , Serbia.
    Purpose: Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication.

    Materials And Methods: Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Read More

    Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts.
    Matrix Biol 2016 Dec 20. Epub 2016 Dec 20.
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, United States; Department of Oral and Maxillofacial Surgery/Skeletal Biology Research Center, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA, United States. Electronic address:
    Our previous studies of Antxr1 knockout mice suggested that fibrotic skin abnormalities in these mice are associated with increased VEGF signaling. Here, based on studies of primary fibroblasts isolated from skin of Antx1+/+ and Antxr1-/- mice at embryonic stage E17.5 and postnatal day P49, we conclude that increased Col1a1 and Fn1 expression in Antxr1-deficient fibroblasts is partly mediated by a cell-autonomous ANTXR1-dependent mechanism. Read More

    Utility of sodium tetradecyl sulfate sclerotherapy from benign oral vascular lesion.
    Maxillofac Plast Reconstr Surg 2016 Dec 25;38(1):44. Epub 2016 Nov 25.
    Department of Oral & Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 South Korea.
    Background: Hemangioma and vascular malformation are benign vascular lesions that often occur in cephalic and cervical region. Currently, surgical resection, laser therapy, angiographic embolization, use of steroids, and sclerotherapy are used as treatments.

    Case Presentation: This study reports three cases of benign vascular lesions that are remarkably treated by sodium tetradecyl sulfate (STS) injection, of which occurred in oral cavity and around the mouth. Read More

    Sclerotherapy of Intraoral Superficial Hemangioma.
    Case Rep Dent 2016 23;2016:4320102. Epub 2016 Nov 23.
    Department of Oral Surgery, Medical Faculty, University of Prishtina, Dental Branch, 10000 Prishtina, Kosovo.
    Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. Read More

    Report of a case of acinic cell carcinoma of the upper lip and review of Japanese cases of acinic cell carcinoma of the minor salivary glands.
    J Clin Exp Dent 2016 Dec 1;8(5):e638-e644. Epub 2016 Dec 1.
    Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.
    Acinic cell carcinoma (ACC) is a malignant tumor of the salivary glands. The majority of ACCs occur in the parotid gland, and ACCs of the minor salivary glands (MSGs) are relatively infrequent. We describe here a patient with ACC of the upper lip. Read More

    Diagnostic approach to intramasseteric nodules.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan 15;123(1):e16-e21. Epub 2016 Oct 15.
    Oral Diagnosis Department, Semiology and Oral Pathology, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Sao Paulo, Brazil. Electronic address:
    Intramuscular nodules can be the clinical presentation of several groups of lesions, such as reactive disorders and benign and malignant tumors. Here, we present three cases with similar clinical features and image aspects on Doppler ultrasonography. Two of the lesions were diagnosed as intramasseteric hemangioma and the third as intramasseteric metastasis from high-grade pleomorphic sarcoma of the thigh. Read More

    The clinico-radiological spectrum of masseteric venous malformation: Case report.
    J Oral Biol Craniofac Res 2016 Nov 26;6(Suppl 1):S58-S61. Epub 2015 Sep 26.
    Reader, Department of Periodontology, People's Dental Academy, Bhopal, India.
    Due to its location, intra-masseteric venous malformation often mistaken for a parotid swelling and clinical examination alone frequently underestimates the deep extension of the lesion and rarely gives accurate pre-operative diagnosis. But once it is diagnosed, the feasibility of the treatment and the plan of approach depend on accurate delineation of the extent, size and location of the lesion. Therefore, complimentary radiographic studies are essential for its management. Read More

    Hemangioma of the oral and perioral region: Nd:YAG vs surgery.
    Ann Ital Chir 2016 Oct 14;2578. Epub 2016 Oct 14.
    Introduction: Hemangiomas are very commonly diagnosticated in childhood. The area most affected by this disease is the head and neck. In recent decades, the laser therapy has changed the treatment of hemangiomas through special techniques with advantages in bleeding risk management. Read More

    [Unexpected cutaneous purpura in an infant].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Nov;18(11):1154-1157
    Department of Dermatology, Hunan Children's Hospital, Changsha 410007, China.
    A two-month-old boy visited the hospital due to unexpected cutaneous purpura and thrombocytopenia for 2 days. The physical examination revealed a purple mass on the back. The soft tissue color Doppler ultrasound showed rich blood signals in the tissue, and the results of bone marrow puncture indicated an increased number of megakaryocytes. Read More

    Clinical Outcomes of Infants With Periorbital Hemangiomas Treated With Oral Propranolol.
    J Oral Maxillofac Surg 2016 Nov 2;74(11):2193-2199. Epub 2016 May 2.
    Professor and Chairman, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China. Electronic address:
    Purpose: Periorbital infantile hemangiomas (IHs) require early intervention because they have the potential risk of causing visual disturbances. In recent years, propranolol has shown promise in the effective management of periocular and periorbital IHs. The objective of our study was to assess the clinical outcomes, efficacy, and safety of propranolol in the management of infants with high-risk periorbital IHs. Read More

    Spindle cell haemangioma of the tongue.
    J Cutan Pathol 2016 Nov 19;43(11):1025-1027. Epub 2016 Aug 19.
    Oral and Maxillofacial Department, Royal United Hospital Bath, Bath, UK.
    Background: Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor that rarely occurs in the mouth.

    Methods And Results: We present an SCH arising in the tongue of a 52-year-old otherwise healthy woman. SCH should be considered in the differential diagnosis of vascular tumors in the oral cavity and not misinterpreted as a more aggressive vascular tumor. Read More

    Therapeutic Effect of Propranolol in Mexican Patients with Infantile Hemangioma.
    Drugs Real World Outcomes 2016 Mar;3(1):25-31
    Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana, Mexico.
    Background: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors.

    Objective: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol. Read More

    Safety of Oral Propranolol for the Treatment of Infantile Hemangioma: A Systematic Review.
    Pediatrics 2016 Oct;138(4)
    Pierre Fabre Dermatologie, Lavaur, France.
    Background And Objectives: Given the widespread use of propranolol in infantile hemangioma (IH) it was considered essential to perform a systematic review of its safety. The objectives of this review were to evaluate the safety profile of oral propranolol in the treatment of IH.

    Methods: We searched Embase and Medline databases (2007-July 2014) and unpublished data from the manufacturer of Hemangiol/Hemangeol (marketed pediatric formulation of oral propranolol; Pierre Fabre Dermatologie, Lavaur, France). Read More

    Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma.
    JCI Insight 2016 Sep 8;1(14):e88856. Epub 2016 Sep 8.
    Department of Otolaryngology - Head and Neck Surgery, University of Washington, Seattle, Washington, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington, USA.
    Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1-expressing (GLUT-1-expressing) IH endothelial cells and in the plasma of children with IH. Read More

    A Solitary Phlebolith in the Buccal Mucosa: Report of a Rare Entity and Clinicopathologic Correlation.
    J Contemp Dent Pract 2016 Aug 1;17(8):706-10. Epub 2016 Aug 1.
    Department of Oral and Maxillofacial Pathology, Vishnu Dental College and Hospital, Bhimavaram, Andhra Pradesh India.
    Pathological conditions can give rise to calcifications within oral mucosa representing either a local or systemic disturbance. Inflammation, trauma, debris acting as nidus and vascular lesions have been attributed as principal causes for occurrence of calcifications within the oral mucosa. Occurrence of multiple calcified thrombi (phleboliths) is considered pathognomonic for hemangiomas and vascular malformations in the oral and maxillofacial region. Read More

    [A clinical case of hemangioma of the face and tongue concurrent with severe obstructive sleep apnea syndrome complicated by cardiac arrhythmias and conduction disturbances].
    Ter Arkh 2016;88(8):105-10
    A.L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex, Ministry of Health of Russia, Moscow, Russia.
    The paper describes a clinical case of a female patient with severe obstructive sleep apnea syndrome in the presence of congenital hemangioma of the face, soft palate, and tongue concurrent with paroxysmal atrial fibrillation and atrial flutter, paroxysmal supraventricular tachycardia, and sinoatrial block (maximally up to 3.9 sec). Continuous positive airway pressure therapy could reduce the number of paroxysms of atrial fibrillation and atrial flutter, supraventricular tachycardia and eliminate sinoatrial block. Read More

    [Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas].
    Shanghai Kou Qiang Yi Xue 2016 Jun;25(3):257-60
    Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.
    Infantile hemangioma (IH) is one of the most common benign vascular tumors in children. A variety of treatment methods have been documented for the management of IH over the past years, including pharmacotherapy via oral administration or injection of corticosteroids, vincristine, alpha interferon and bleomycin; laser therapy, radionuclide therapy, cryotherapy and excisional surgery. The therapeutic efficacy of each treatment modality is variable, while adverse effects or complications are common and sometimes serious. Read More

    Sclerotherapy and cryotherapy in the management of oral vascular lesions: a series of 10 cases.
    Gen Dent 2016 Sep-Oct;64(5):25-9
    Vascular anomalies such as hemangiomas or vascular malformations can produce negative esthetic effects in the maxillofacial region. These negative effects are the main complaints of patients. The clinical therapeutic efficacy of cryotherapy and sclerotherapy in the treatment of these lesions was evaluated in 10 patients who were clinically diagnosed with vascular lesions. Read More

    Evaluation of the efficacy and safety of topical timolol maleate combined with oral propranolol treatment for parotid mixed infantile hemangiomas.
    Oncol Lett 2016 Sep 7;12(3):1806-1810. Epub 2016 Jul 7.
    Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang, Liaoning 110002, P.R. China.
    The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1. Read More

    Use of Propranolol for Treating Hemangiomas in Infants with Previously Diagnosed Hypoglycemic Conditions.
    Pediatr Dermatol 2016 Nov 30;33(6):e381-e384. Epub 2016 Aug 30.
    Division of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA.
    Infantile hemangiomas (IHs) are the most common pediatric vascular tumors. They require therapy when they cause severe complications such as ulceration, amblyopia, or airway constriction. Propranolol is the only treatment that the U. Read More

    Topical Treatment of Infantile Haemangiomas: A Comparative Study on the Selection of a Semi-Solid Vehicle.
    Skin Pharmacol Physiol 2016 18;29(4):210-9. Epub 2016 Aug 18.
    Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.
    Background/aim: Topical β-blockers have recently been proposed as a valid alternative to oral drugs for treating cutaneous infantile haemangiomas, but clinical results in the literature are inconsistent due to the empirical choice of topical preparations. The current investigation aimed to rationalize the selection of a semi-solid vehicle for a locally applied drug product containing 1% w/w propranolol hydrochloride (PR-Cl).

    Methods: A hydrophobic ointment of PR-Cl, two lipophilic creams, and a hydrophilic cream were prepared. Read More

    Clinical features and management of multifocal hepatic hemangiomas in children: a retrospective study.
    Sci Rep 2016 Aug 17;6:31744. Epub 2016 Aug 17.
    Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
    Multifocal hepatic hemangioma (MHH) is a benign hepatic tumor that is commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present a review of all children with MHH at our institutions. Of the 42 patients, the median age at presentation of MHH was 2. Read More

    Topical Timolol Maleate Treatment of Infantile Hemangiomas.
    Pediatrics 2016 Sep 15;138(3). Epub 2016 Aug 15.
    University of California, San Francisco, San Francisco, California;
    Background: There has been a dramatic increase in the off-label use of ophthalmic timolol maleate, a β-blocker used for infantile hemangioma (IH) treatment as a topical counterpart to oral propranolol. Its safety and efficacy in a pediatric population with IH have not been evaluated in a large cohort. Our goal was to retrospectively assess timolol's effectiveness, discern characteristics associated with response, and document reported adverse events. Read More

    Intramuscular hemangioma of the masseter muscle- a case report and review of literature.
    Int J Surg Case Rep 2016 25;26:209-16. Epub 2016 Jul 25.
    Department of Oral and Maxillofacial Pathology, Trivandrum, Kerala, India. Electronic address:
    Introduction: Intramuscular hemangioma, is a distinctive type of vascular tumor occurring within the skeletal muscle. Most IMH are located in the lower extremity, particularly in the muscles of the thigh and rarely in head and neck region.

    Presentation Of Case: 35 years old male reported with a swelling in the left cheek region since 3 years. Read More

    Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study.
    Pathol Res Pract 2016 Sep 18;212(9):761-6. Epub 2016 May 18.
    Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address:
    In view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n=10), inflammatory fibrous hyperplasia (IFH, n=10), peripheral giant cell lesion (PGCL, n=10) and lobular capillary hemangioma (LCH, n=7) were investigated using immunohistochemistry for mast cell tryptase and CD34. For comparative purposes, central giant cell lesions (CGCL, n=5) were included. Read More

    Corticosteroids as an adjunct to propranolol for infantile haemangiomas complicated by recalcitrant ulceration.
    Br J Dermatol 2016 Aug 1. Epub 2016 Aug 1.
    Department of Dermatology, Division of Pediatric Dermatology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Unit 2107, Baltimore, 21287, MD, U.S.A.
    A small subset of patients with infantile haemangiomas (IHs) can present with serious complications, the most common of which is ulceration. Ulcerated IHs can be extremely painful and always result in scarring. Numerous studies support the efficacy and reduced side-effects of propranolol relative to systemic corticosteroids, which led to the adoption of propranolol as the mainstay of IH treatment. Read More

    Low-dose propranolol for infantile hemangioma of the head and neck: Analysis of 23 consecutive patients.
    Pediatr Int 2017 Feb 20;59(2):213-217. Epub 2016 Nov 20.
    Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Background: More and more infantile hemangiomas (IH) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute. The aim of this observational study was to describe the therapeutic response, tolerance, and safety of low-dose propranolol in 23 children with IH of the head and neck.

    Methods: Data were collected from the medical charts of patients treated with low-dose propranolol from December 2009 through November 2011. Read More

    Effective treatment for infantile hemangioma with long-pulsed dye laser with oral propranolol medication: a preliminary report.
    Pediatr Surg Int 2016 Sep 26;32(9):857-62. Epub 2016 Jul 26.
    Department of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 241-8511, Japan.
    Purpose: To investigate the efficacy of our treatment of infantile hemangioma (IH)s retrospectively presenting as disfiguring or functionally threatening lesions.

    Materials And Methods: 25 infants with IH treated with long-pulsed dye laser or laser with or without propranolol. Tumor fading after treatment was evaluated using both color and size rating scales, before, during and after treatment. Read More

    Severe Edema After Sclerotherapy of Labial Hemangioma With Ethamolin Oleate in a Young Child.
    J Craniofac Surg 2016 Sep;27(6):e567-8
    *Surgery and Integrated Clinic Department, Araçatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba †School of Post-graduate Quixadaense (EQUIP), Quixadá, Brazil.
    Adverse reactions related to ethanolamine oleate (EO) include pain during injection, redness, inflammation, tissue necrosis, and allergic reaction. The authors report a patient of exuberant facial edema after the injection of EO used in sclerotherapy of lip hemangioma in a child. A 9-year-old boy was referred to authors' oral and maxillofacial surgery unit to treat a vascular lesion of the upper lip. Read More

    Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia.
    Case Rep Gastrointest Med 2016 15;2016:4398401. Epub 2016 Jun 15.
    Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
    Pyogenic granuloma (PG), more accurately known as lobular capillary hemangioma, is a benign vascular tumor that usually occurs in the skin or oral mucosa. This lesion is rarely reported in the gastrointestinal tract but is known to bleed if not resected. We herein describe a case series with the clinical, endoscopic, and histologic findings of four cases of gastrointestinal PG at our institution. Read More

    Resection of Giant Hemangioma of the Tongue Utilizing a Miniature Tourniquet Technique.
    J Craniofac Surg 2016 Jul;27(5):e447-50
    West Bloomfield, MI.
    With the progress of multidisciplinary vascular anomaly treatment, the use of radiotherapy, cryotherapy, laser therapy and medical treatments, the corticosteroid, sclerotherapy, and many more, the role of surgery has been refined. Surgical treatment has historically been the mainstay of treatment and will maintain.A miniature tourniquet technique applied to the tongue was successfully utilized in reducing bleeding to a minimum during surgical resection of a massive cavernous hemangioma involving the tongue and lower lip without any postoperative complications. Read More

    Central cavernous hemangioma of mandible: Case report and review of literature.
    Natl J Maxillofac Surg 2015 Jul-Dec;6(2):209-13
    Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
    Intraosseous hemangiomas are one of the rarest lesion of jaw bones (0.5-1%) occurring most commonly in vertebral column, skull bone, and rarely in mandible. Mainly occurs in the second decade of life with female: male predilection (2:1). Read More

    The Histopathological Spectrum of Pyogenic Granuloma: A Case Series.
    Case Rep Dent 2016 12;2016:1323798. Epub 2016 Jun 12.
    Department of Periodontics & Implantology, College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan, Sunsari 56700, Nepal.
    Background. Pyogenic granuloma is a reactive tumor-like lesion commonly affecting the oral cavity. These lesions usually appear as localized solitary nodule with a sessile or pedunculated base and colour varying from red, purplish, or pink, depending on the vascularity of the lesion. Read More

    Prevalence and distribution of oral mucosal non-malignant lesions in the western Sicilian population.
    Minerva Stomatol 2016 Aug;65(4):191-206
    Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Palermo, Italy -
    Backgroung: The aim of the present study was to determine the prevalence of oral mucosal non-malignant lesions in the Sicilian population. In addition, we evaluated the association between each oral lesion and its risk factors.

    Methods: This study analyzed a total of 2539 consecutive patients, attending the Department of Surgical, Oncological and Stomatological Disciplines of Palermo University, who were examined for the presence of various oral lesions during the period from January 2012 and February 2015. Read More

    Propranolol treatment for infantile hemangioma: a case series of sixty-two patients.
    Pediatr Med Chir 2016 Jun 27;38(2):113. Epub 2016 Jun 27.
    Department of Pediatrics, Parma University Hospital, Parma.
    Infantile hemangiomas (IH) complicated by ulceration, disfigurement, functional impairment or life-threatening conditions need early, safe and effective treatment. This study explores the impact of propranolol on complicated IH. We report our experience of 62 patients treated with oral propranolol for complicated IH. Read More

    Diseases of the tongue.
    Clin Dermatol 2016 Jul-Aug;34(4):458-69. Epub 2016 Mar 8.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    The tongue is a complex organ involved in speech and expression as well as in gustation, mastication, and deglutition. The oral cavity, along with the tongue, are sites of neoplasms, reactive processes, and infections, and may be a harbinger of systemic diseases. This review includes both common and rare diseases that occur on the tongue, including: vascular and lymphatic lesions (infantile hemangiomas and oral varices), reactive and inflammatory processes (hairy tongue, pigmented fungiform papillae of the tongue, benign migratory glossitis, and fissured tongue), infections (oral hairy leukoplakia, herpes simplex and varicella-zoster virus infections, human papillomavirus, and candidiasis), premalignant lesions (leukoplakia and erythroplakia), malignant lesions (squamous cell carcinoma, Kaposi sarcoma, and lymphoproliferative diseases), and signs of systemic disease (nutritional deficiency and systemic amyloidosis). Read More

    Multifocal infantile haemangioma: a diagnostic challenge.
    BMJ Case Rep 2016 Jun 17;2016. Epub 2016 Jun 17.
    Department of Dermatology, Hospital de Santa Maria-Centro Hospitalar de Lisboa Norte, Lisbon, Portugal.
    We describe a case of a newborn who presented with multiple dark red macules that developed into red-to-purple papules associated with thrombocytopaenia. Abdominal ultrasound showed multiple hyperechoic papules and nodules. Endothelial cells from a skin biopsy stained positively for endothelial cell glucose transporter 1, which was consistent with a diagnosis of multifocal infantile haemangioma. Read More

    Oral atenolol therapy for proliferating infantile hemangioma: A prospective study.
    Medicine (Baltimore) 2016 Jun;95(24):e3908
    aDivision of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China bPediatric Intensive Care Unit, West China Hospital of Sichuan University, Chengdu, China.
    Propranolol, a lipophilic nonselective β-blocker, has recently been reported to be the treatment of choice for select types of infantile hemangiomas (IHs). Atenolol is a hydrophilic, selective β1-blocker and therefore may be not associated with side effects attributable to β2-adrenergic receptor blockade and lipophilicity. However, the efficacy and safety of atenolol in the treatment of IH are poorly understood. Read More

    Excellent response of infantile orofacio-orbital hemangioma to propranolol-pictorial depiction and literature review.
    Contemp Clin Dent 2016 Apr-Jun;7(2):269-72
    Department of Pediatric Surgery, Employees State Insurance Corporation, Super Speciality Hospital, Hyderabad, Telangana, India.
    Infantile hemangiomas (IHs) are common, benign vascular tumors of infancy, with more than half affecting the head and neck region. IHs involving the lips and oral cavity can often present to the oral surgeon and the pedodontist. Till date, several doubts exist among clinicians regarding the use of propranolol to treat infantile hemangiomas in neonates and small infants, appropriate dose, treatment duration, side effects, response, and long-term follow-up. Read More

    Role of oral propranolol in the treatment of infantile subglottic hemangioma.
    Int J Clin Pharmacol Ther 2016 Sep;54(9):675-81
    Objective: To determine the efficacy of oral propranolol for the treatment of infantile subglottic hemangioma.

    Methods: 17 children (13 females and 4 males) with a median age at onset of treatment of 5 months were included in this study. Propranolol was administered after the presence of subglottic hemangioma was confirmed by laryngoscopy and a CT scan of the trachea with contrast. Read More

    Response of Blue Rubber Bleb Nevus Syndrome to Sirolimus Treatment.
    Pediatr Blood Cancer 2016 Nov 8;63(11):1911-4. Epub 2016 Jun 8.
    Vascular Anomalies Center, Boston Children's Hospital, Boston, Massachusetts.
    Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation syndrome involving predominantly the skin and gastrointestinal tract. Traditional treatment modalities include corticosteroids, interferon-α, sclerotherapy, and aggressive surgical resection. Sirolimus has been used in several single case reports. Read More

    Adverse Events in Young and Preterm Infants Receiving Topical Timolol for Infantile Hemangioma.
    Pediatr Dermatol 2016 Jul 31;33(4):405-14. Epub 2016 May 31.
    Department of Dermatology , Medical College of Wisconsin, Milwaukee, Wisconsin.
    Background: The success of oral propranolol for treatment of infantile hemangiomas (IHs) has led practitioners to use topical β-blockers. In preterm infants, clinicians frequently turn to topical timolol, with the presumption that topical application will result in less systemic absorption. We used Holter monitoring to assess for drug-induced bradycardia in high-risk infants. Read More

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