2,484 results match your criteria Oral Hemangiomas


Secondary Cleft Lip Induced by Congenital Hemangioma: Report of a Rare Case.

Ear Nose Throat J 2020 May 13:145561320925937. Epub 2020 May 13.

Department of Oral and Maxillofacial Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.

Infant hemangioma is a relatively rare congenital disease. Ulcer and infection may occur in some cases. A few cases may develop into deformity and defect. Read More

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http://dx.doi.org/10.1177/0145561320925937DOI Listing

VATS approach for pulmonary sclerosing pneumocytoma: a case report.

Acta Chir Belg 2020 May 19:1-4. Epub 2020 May 19.

Department of Thoracic Surgery, CHU St Pierre, Brussels, Belgium.

Pulmonary Sclerosing Pneumocytoma (PSP) is a rare type of benign lung tumor usually encountered in middle-aged Asian women. The lesion is mostly found on routine chest x-rays. Though surgery is recognized as the recommended treatment, there is no consensus on the standard operative procedure for this tumor. Read More

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http://dx.doi.org/10.1080/00015458.2020.1765671DOI Listing

Infantile Hemangioma: An Updated Review.

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Department of Paediatrics, The Chinese University of Hong Kong, and Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital. Hong Kong.

Background: Infantile hemangiomas are the most common vascular tumors of infancy affecting up to 12% of infants by the first year of life.

Objective: To familiarize physicians with the natural history, clinical manifestations, diagnosis, and management of infantile hemangiomas.

Methods: A Pubmed search was conducted in November 2019 in Clinical Queries using the key term 'infantile hemangioma'. Read More

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http://dx.doi.org/10.2174/1573396316666200508100038DOI Listing

Histopathological analysis of biopsies of "peri-implant inflammatory lesions." Everything is not what it seems.

Clin Implant Dent Relat Res 2020 May 7. Epub 2020 May 7.

Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Peri-implantitis is the inflammatory process, which most commonly affects the therapy with dental implants. However, there are other reactive and neoplastic entities, mainly benign but also malignant, which also take place in the peri-implant mucosa. There is little information about the histopathological analysis of these peri-implant inflammatory diseases. Read More

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http://dx.doi.org/10.1111/cid.12905DOI Listing

Robotic, laparoscopic or open hemihepatectomy for giant liver haemangiomas over 10 cm in diameter.

BMC Surg 2020 May 6;20(1):93. Epub 2020 May 6.

Department of Hepatobiliary and Pancreatic Surgical Oncology, Chinese PLA General Hospital and Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China.

Background: To evaluate the clinical efficacy of robotic, laparoscopic, and open hemihepatectomy for giant liver haemangiomas.

Methods: From April 2011 to April 2017, consecutive patients who underwent hemihepatectomy for giant liver haemangiomas were included in this study. According to the type of operation, these patients were divided into the robotic hemihepatectomy (RH) group, the laparoscopic hemihepatectomy (LH) group, and the open hemihepatectomy (OH) group. Read More

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http://dx.doi.org/10.1186/s12893-020-00760-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204244PMC

Beta Blocker Therapy for Congenital Hepatic Arteriovenous Fistula in Two Neonates.

Front Pediatr 2020 21;8:163. Epub 2020 Apr 21.

Department of Pediatric Cardiology, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Hepatic arteriovenous fistula (HAVF) is an abnormal communication between the hepatic arteries and hepatic veins. This condition is treated mainly using interventional closure and surgery. However, these procedures are associated with many postoperative complications and high mortality. Read More

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http://dx.doi.org/10.3389/fped.2020.00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186415PMC

Surgical Treatment of Aggressive Intraosseous Cavernous Hemangioma in Maxilla Through Surgical Resection.

J Craniofac Surg 2020 May 4. Epub 2020 May 4.

São Leopoldo Mandic Dental School, Santa Casa de Misericórdia Hospital of São Miguel dos Campos, São Miguel dos Campos, Brazil.

Hemangiomas are benign vascular lesions characterized by endothelial vascular proliferation and may demonstrate aggressive clinical features. Intraosseous hemangiomas are uncommon and the maxillary location rare, with few cases described in the literature. The treatment of these lesions varies, however they have a better prognosis when a surgical treatment through resection is performed. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006382DOI Listing

Propranolol Specifically Suppresses the Viability of Tumorous Schwann Cells Derived from Plexiform Neurofibromas .

In Vivo 2020 May-Jun;34(3):1031-1036

Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background/aim: Plexiform neurofibromas (PNFs) are benign tumors of the periph eral nerves sheath, which can damage neighboring organs, impair functions, cause pain and serious maxillofacial disfigurement, and have a high risk of malignant transformation. Complete resection is usually not possible since PNFs often extend through multiple layers of tissue. Therefore, it is necessary and beneficial to find a reasonable drug treatment for PNFs. Read More

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http://dx.doi.org/10.21873/invivo.11872DOI Listing
February 2020

Serum cytokine profiles in infants with infantile hemangiomas on oral propranolol treatment: VEGF and bFGF, potential biomarkers predicting clinical outcomes.

Pediatr Res 2020 Apr 20. Epub 2020 Apr 20.

Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea.

Background: Oral propranolol has become first-line treatment for infantile hemangiomas (IHs). This study focused on identifying cytokines related to the biology of IH and early regression indicators of IH after propranolol treatment.

Methods: For inclusion, the patients had to be aged less than 1 year and have an IH with a largest diameter ≥2 cm. Read More

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http://dx.doi.org/10.1038/s41390-020-0862-1DOI Listing

Limited Utility of Repeated Vital Sign Monitoring During Initiation of Oral Propranolol for Complicated Infantile Hemangioma.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

School of Medicine and Public Health, University of Wisconsin.

Background: Initial propranolol recommendations for infantile hemangioma published in 2013 were intended as provisional best practices to be updated as evidence-based data emerged.

Methods: A retrospective multicenter study was performed to evaluate utility of prolonged monitoring after first propranolol dose and escalation(s). Inclusion criteria included diagnosis of hemangioma requiring propranolol of ≥0. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.013DOI Listing

Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review.

Curr Drug Metab 2020 Apr 13. Epub 2020 Apr 13.

Department of Pharmacy, Quaid-i-Azam University,45320, Islamabad. Pakistan.

Background: Nobel laureate Sir James Black's molecule, propranolol, still has broad acceptance in cardiovascular diseases, infantile haemangiomas and anxiety. A comprehensive and systematic review of the literature for the summarization of pharmacokinetic parameters would be effective in order to explore the new safe uses of propranolol in different scenarios, without exposing humans and using virtual-human modeling approaches.

Objective: This review encompasses physico-chemical properties, pharmacokinetics and drug-drug interaction data of propranolol collected from various studies. Read More

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http://dx.doi.org/10.2174/1389200221666200414094644DOI Listing
April 2020
2.976 Impact Factor

Clinical Results of Various Treatments for Retinal Capillary Hemangioma.

Korean J Ophthalmol 2020 Apr;34(2):133-142

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: We report the clinical outcomes of retinal capillary hemangioma (RCH) after the application of various treatments.

Methods: We performed a retrospective chart analysis of eight eyes treated for RCH between August 2009 and January 2018. During the follow-up period, the status and progression of the RCHs were checked by fundus photography, fluorescein angiography, and optical coherence tomography, and additional treatments were applied when necessary. Read More

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http://dx.doi.org/10.3341/kjo.2019.0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105784PMC

Modalities of use of oral propranolol in proliferative infantile haemangiomas: an international survey among practitioners.

Br J Dermatol 2020 Mar 27. Epub 2020 Mar 27.

CHRU Tours, Department of Dermatology, Unit of Pediatric Dermatology and Reference Center for Rare Diseases and Vascular Malformations (MAGEC), CHRU Tours, 37044, Tours CEDEX 9, France.

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http://dx.doi.org/10.1111/bjd.19047DOI Listing

Influence of Cytochrome P450 2D6 Polymorphisms on the Efficacy of Oral Propranolol in Treating Infantile Hemangioma.

Biomed Res Int 2020 7;2020:8732871. Epub 2020 Mar 7.

Department of Clinical Pharmacology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, China.

Objective: The aim of this study is to evaluate the association of genetic polymorphisms in Cytochrome P450 2D6(CYP2D6) and the change in VEGF levels with the response to propranolol in patients with Infantile hemangiomas (IH).

Methods: IH patients who underwent over six months of propranolol therapy and received oral propranolol only were enrolled. The target dose of propranolol was 1 mg kgday. Read More

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http://dx.doi.org/10.1155/2020/8732871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081015PMC

Oral propranolol administration is effective for infantile hemangioma in late infancy: A retrospective cohort study.

Dermatol Ther 2020 Mar 26:e13331. Epub 2020 Mar 26.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

The highest efficacy of oral propranolol is for infantile hemangioma (IH) in the proliferative phase. Evaluation of the effectiveness of oral propranolol is less established when it is administered in late infancy following the proliferative phase. We aimed to assess the clinical outcomes of pediatric patients managed by oral propranolol beyond the proliferative phase of IH. Read More

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http://dx.doi.org/10.1111/dth.13331DOI Listing

Enhanced efficacy of propranolol therapy for infantile hemangiomas based on a mesoporous silica nanoplatform through mediating autophagy dysfunction.

Acta Biomater 2020 04 4;107:272-285. Epub 2020 Mar 4.

Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250012, China; Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250012, China. Electronic address:

Infantile hemangioma is one of the most common vascular tumors, which might result in morbidity and mortality without timely intervention. Propranolol is currently the first-line therapy for hemangiomas, but its potential side effects and high frequency of administration make it urgent to develop a suitable drug delivery system for propranolol. In the present study, we formulated a propranolol delivery system based on mesoporous silica nanoparticles (PRN@MSN) and investigated the interplay between autophagic activities mediated by nanoparticles and improved therapeutic efficacy of PRN@MSN. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.02.033DOI Listing
April 2020
6.025 Impact Factor

Pseudomyogenic Hemangioendothelioma: A Rare Vascular Tumor of the Oral Cavity.

J Craniofac Surg 2020 Feb 28. Epub 2020 Feb 28.

Oral and Maxillofacial Surgery, University of Puerto Rico, San Juan, Puerto Rico.

Pseudomyogenic hemangioendothelioma is a vascular neoplasm that presents a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Up to date, only 1 case of this entity has been reported in the oral cavity. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006253DOI Listing
February 2020

Special management considerations for propranolol use in breastfed infants of mothers taking antihypertensives.

Pediatr Dermatol 2020 Feb 28. Epub 2020 Feb 28.

Division of Dermatology, Children's National Hospital, Washington, DC, USA.

Propranolol is approved for treatment of infantile hemangiomas (IH). IH proliferation coincides with the time when most women are breastfeeding, yet there are no reports describing the clinical effects on infants treated with propranolol while being nursed by mothers on oral antihypertensive medications. We describe two cases of breastfed infants, with mothers taking multiple antihypertensives of different drug classes, who were initiated on propranolol for IH treatment and discuss the theoretical risk of propranolol use in this setting. Read More

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http://dx.doi.org/10.1111/pde.14134DOI Listing
February 2020
1.520 Impact Factor

Camrelizumab (SHR-1210) leading to reactive capillary hemangioma in the gingiva: A case report.

World J Clin Cases 2020 Feb;8(3):624-629

Department of Periodontology, School and Hospital of Stomatology, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan 250012, Shandong Province, China.

Background: Oncologic immunotherapy is attracting attention as an effective strategy for cancer treatment. Currently, there are two kinds of inhibitors: Anti-PD-1 antibodies and anti-PD-L1 antibodies. These inhibitors have shown significant implications in improving the outcomes of certain cancer types in recent years. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i3.624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031842PMC
February 2020

Success in the use of oral propranolol in the treatment of infantile hemangioma in nasal tip - Report of two cases.

An Bras Dermatol 2020 Mar - Apr;95(2):207-209. Epub 2020 Jan 21.

Service of Dermatology, Hospital Universitário de Brasília, Brasília, DF, Brazil.

Infantile hemangioma is the most common pediatric vascular tumor, with the following risk factors: low birth weight, prematurity, white skin, female gender, multiparity and advanced maternal age. The use of oral and topical beta-blockers, although recent, has emerged as the first line of treatment, with superior safety and efficacy to previously used therapies, such as corticosteroids and surgeries. This report describes two cases of nasal tip infantile hemangioma, treated with oral propranolol. Read More

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http://dx.doi.org/10.1016/j.abd.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175038PMC

Intramuscular Hemangioma of the Masseter.

Arch Iran Med 2020 02 1;23(2):144-145. Epub 2020 Feb 1.

Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research [KLE University], Belagavi- 590010, Karnataka, India.

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February 2020

Monoethanolamine oleate sclerotherapy for the treatment of intraoral vascular anomalies: retrospective study and suggestion for a clinical guideline.

Br J Oral Maxillofac Surg 2020 May 11;58(4):416-420. Epub 2020 Feb 11.

Department of Dentistry, Maringá State University, Maringá, Paraná, Brazil.

Vascular anomalies are common in the head and neck, and oral lesions are most commonly found on the lips, tongue, mucosa, and palate. Monoethanolamine oleate sclerotherapy (MOS) is an option for treatment, although we know of no established protocols yet. We report the prevalence and characteristics of intraoral vascular anomalies (IVA) and the results achieved with the use of 5% MOS, and suggest a clinical guideline. Read More

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http://dx.doi.org/10.1016/j.bjoms.2020.01.020DOI Listing

Effect of combined low-dose oral prednisone with beta-adrenergic receptor antagonists for refractory infantile hemangiomas: retrospective cohort study in 76 patients.

Ann Transl Med 2019 Dec;7(23):750

Department of Interventional Therapy, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Background: Beta-adrenergic receptor antagonists have been the first-line treatment for infantile hemangiomas (IHs); however, monotherapy may fail to achieve sufficient efficacy for certain patients, especially for refractory IHs. The aim of this study was to evaluate the efficacy and safety of the combination of prednisone and beta-adrenergic receptor antagonists for refractory IHs.

Methods: We studied 76 patients with refractory IHs. Read More

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http://dx.doi.org/10.21037/atm.2019.11.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989970PMC
December 2019

A case series of tardive expansion congenital hemangioma: A variation of noninvoluting congenital hemangioma or a new hemangiomatous entity?

J Am Acad Dermatol 2020 Feb 4. Epub 2020 Feb 4.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. Electronic address:

Background: Congenital hemangiomas present fully grown at birth and share a remarkably similar lack of disproportionate or accelerated postnatal proliferation.

Objective: We report a series of unusual congenital hemangiomas that arise prenatally and initially exhibit a proportional growth pattern similar to that of noninvoluting congenital hemangioma. However, a tardive expansion of the lesion, similar to the proliferation phase of infantile hemangioma, occurs later during childhood. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.01.069DOI Listing
February 2020

Oral propranolol for the treatment of infantile haemangiomas in Singapore.

Singapore Med J 2020 Jan 28. Epub 2020 Jan 28.

Dermatology Service, KK Women's and Children's Hospital, Singapore.

Introduction: Infantile haemangiomas (IH) are the most common vascular tumours in childhood. Over the past decade, treatment of IH has been revolutionised by the discovery of the effectiveness of beta-blockers in its treatment. We review our hospital's experience with oral propranolol in the treatment of IH in an Asian population. Read More

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http://dx.doi.org/10.11622/smedj.2020008DOI Listing
January 2020

Management of the oral hemangiomas in infants and children: Scoping review.

Med Oral Patol Oral Cir Bucal 2020 Mar 1;25(2):e252-e261. Epub 2020 Mar 1.

Facultad de Estomatología Universidad Autónoma de San Luis Potosí Av. Dr. Manuel Nava #2, Zona Universitaria C.P. 78290, San Luis Potosí, S.L.P. México

Background: Pediatric oral hemangiomas are benign vascular tumors that can be seen from birth, particularly in females. Hemangiomas are most frequent located in the lips and usually regress spontaneously, thus they do not require any type of treatment in most cases. The present scoping review pretended to synthesize the most relevant and currently available information from the international dental literature published in the last 25 years, regarding the management of pediatric oral hemangiomas. Read More

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http://dx.doi.org/10.4317/medoral.23329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103441PMC

Submandibular Gland Hemangioma.

Plast Reconstr Surg Glob Open 2019 Jul 5;7(7):e2304. Epub 2019 Jul 5.

Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Hemangioma in the submandibular gland or submandibular space is rare. A 31-year-old woman was referred to our department. She became aware of painless swelling in the right submandibular gland at 9 months ago. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952157PMC

Intracranial variant of encephalotrigeminal angiomatosis - A case report.

Indian J Dent Res 2019 Nov-Dec;30(6):978-981

Department of Oral Medicine and Radiology, Vinayaka Missions Research Foundation, Vinayaka Missions Sankarachariyar Dental College (Deemed to be University), Salem, Tamil Nadu, India.

Encephalotrigeminal Angiomatosis is a rare developmental phakomatoses characterized by the occurrence of nevus flammeus (port-wine stain) along the distribution of branches of trigeminal nerve, vascular angiomas in the eye, and leptomeningeal angiomas affecting 1 in 1,00,000 South Asian population. Herewith, such a rare case of such encephalotrigeminal angiomatosis in a 24-year-old male is described. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_517_17DOI Listing
January 2020

A multi-disciplinary, multimodal approach for the management of vascular anomalies.

Pak J Med Sci 2020 Jan;36(1):S14-S19

Lubna Samad, MRCS, FCPS. Department of Pediatric Surgery, Center for Essential Surgical and Acute Care, Global Health Directorate, Indus Health Network, Karachi, Pakistan, The Indus Hospital, Karachi, Pakistan.

Objective: Vascular anomalies are a diverse group of lesions, ranging from simple to complex, disfiguring anomalies. Our objective was to diagnose and provide comprehensive treatment to patients presenting with vascular anomalies, using a multi-disciplinary approach involving dermatologists, plastic surgeons, radiologists and pediatric surgeons.

Methods: Patients presenting with vascular anomalies to The Indus Hospital, Karachi, from January 2017 to March 2019 were enrolled, using a pre-defined questionnaire. Read More

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http://dx.doi.org/10.12669/pjms.36.ICON-Suppl.1710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943111PMC
January 2020

Progress in the treatment of infantile hemangioma.

Ann Transl Med 2019 Nov;7(22):692

Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.

Infantile hemangioma (IH) is a common benign tumor, which mostly resolves spontaneously; however, children with high-risk IH need treatment. Currently, the recognized first-line treatment regimen for IH is oral propranolol, but research on the pathogenesis of IH has led to the identification of new therapeutic targets, which have shown good curative effects, providing more options for disease treatment. This article summarizes the applications of different medications, dosages, and routes of administration for the treatment of IH. Read More

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http://dx.doi.org/10.21037/atm.2019.10.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944559PMC
November 2019

[Treatment of parotid hemangioma in children].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1076-1080

Department of Otolaryngology Head and Neck Surgery, Kunming Children's Hospital(Children's Hospital Affiliated to Kunming Medical University), Yunnan Key Laboratory of Children's Major Disease Research, Kunming, 650228, China.

To summarize the treatment and effect of children with parotid hemangioma. Thirty-three children with parotid hemangioma were treated with drug in 22 cases, 9 of which received propranolol orally, accounting for 27%; 13 cases underwent B-ultrasound guided bleomycin injection, accounting for 40%; another 11 cases were used. The treatment of surgical removal of hemangioma, accounting for 33%. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.11.017DOI Listing
November 2019

Intraossäres Hämangiom im Unterkiefer wenn die Wunde nach der Weisheitszahnentfernung nicht heilt

Swiss Dent J 2020 01;130(1):42-43

Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China

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January 2020

Vascularized ameloblastoma: A case report and clinicopathologic review of 18 cases from the literature.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Oct 26. Epub 2019 Oct 26.

Department of Pathology, Howard University Hospital, Washington, DC, USA.

The notable features of ameloblastoma do not typically include prominent vascularity. However, on rare occasions, vascular ameloblastoma has been described under a variety of names. We present a case of vascularized ameloblastoma that had a bloody return on fine-needle aspiration. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.10.006DOI Listing
October 2019

Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two.

Biomed Res Int 2019 25;2019:2728952. Epub 2019 Nov 25.

Department of Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China.

Objective: To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their relevant factors, as well as the relationship between child growth and propranolol.

Methods: A total of 506 patients with confirmed or suspected IHs were enrolled, and a total of 439 cases were included in the study. Short-term AEs were analysed using single-factor analysis and binary logistic regression. Read More

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http://dx.doi.org/10.1155/2019/2728952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899275PMC

Assessment of Oral Propranolol Administration for Infantile Hemangioma in Oral and Maxillofacial Region Aided by Ultrasonography.

J Craniofac Surg 2020 Jan/Feb;31(1):189-192

Department of Maxillofacial Surgery, Medical City Hospital, Baghdad, Iraq.

Background: Propranolol has become the first-line therapy for the treatment of complicated infantile hemangioma. However, there are still many queries regarding the hemangioma volume in relation to drug's dose and duration.

Objective: The aim of this study was to evaluate the therapeutic effect of oral propranolol for treating infantile hemangiomas in the oral and maxillofacial region aided by gray scale ultrasonography (GSU). Read More

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http://dx.doi.org/10.1097/SCS.0000000000005814DOI Listing
March 2020
0.676 Impact Factor

Computer guided resection and reconstruction of intra-osseous zygomatic hemangioma: Case report and systematic review of literature.

Int J Surg Case Rep 2020 17;66:240-256. Epub 2019 Dec 17.

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt. Electronic address:

Objectives: to systemically integrate the available data on various published treatment strategies for intraosseous hemangioma of the zygoma in an updated comprehensive systematic review, and to present a new case of treated resection and immediate reconstruction using computer guided patient specific composite graft.

Case Presentation: A 29 years old female patient with intraosseos zygomatic hemangioma treated using computer guided resection and immediate reconstruction. The resection was performed using a resection template constructed based on preoperative 3D planning. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931065PMC
December 2019

Lobular Capillary Hemangioma of the Palate -A Case Report.

Iran J Otorhinolaryngol 2019 Nov;31(107):399-402

Department of Otorhinolaryngology, Krishna Institute of Medical Sciences Deemed To Be University, Karad, 415110; Maharashtra, India.

Introduction: Lobular capillary hemangioma (LCH) is caused by exuberant neovascular response to infection, local irritation (e.g., trauma), or hormonal influence (e. Read More

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http://dx.doi.org/10.22038/ijorl.2019.38928.2285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914325PMC
November 2019

Death Associated With Nadolol for Infantile Hemangioma: A Case for Improving Safety.

Pediatrics 2020 01;145(1)

Department of Emergency Medicine, Regions Hospital, St Paul, Minnesota; and.

Nadolol is a β-adrenergic antagonist that has been shown to be efficacious in the treatment of infantile hemangioma. It has been suggested that this drug may have fewer side effects compared with the gold standard therapy, propranolol, because it does not exhibit membrane-stabilizing effects and has little ability to cross the blood-brain barrier. However, the pharmacokinetics and safety of nadolol in infants are not well understood, potentially making this therapy dangerous. Read More

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http://dx.doi.org/10.1542/peds.2019-1035DOI Listing
January 2020

The effectiveness and safety of topical β-receptor blocker in treating superficial infantile haemangiomas: A meta-analysis including 20 studies.

Br J Clin Pharmacol 2020 Feb 17;86(2):199-209. Epub 2020 Jan 17.

Department of Pediatric Surgery, Baoan Maternal and Child Health Hospital, Jinan University, Shenzhen, China.

Aims: To evaluate the effectiveness and safety of topical β-receptor blocker in treating superficial infantile haemangiomas (SIH) and compare the effectiveness and safety of topical β-receptor blocker against other therapies.

Methods: A search of the literature using PubMed, Embase, Cochrane Review database, China National Knowledge Infrastructure and Wanfang were performed to identify the studies that estimated the effectiveness and safety of topical β-receptor blocker in treating SIH, the fixed-effect or random-effects meta-analytical techniques were applied to assess the outcomes.

Results: Twenty studies, involving 2098 patients, were included to conduct this analysis. Read More

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http://dx.doi.org/10.1111/bcp.14196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015739PMC
February 2020

Evaluating the Safety of Oral Propranolol Therapy in Patients With PHACE Syndrome.

JAMA Dermatol 2019 Dec 11. Epub 2019 Dec 11.

Department of Dermatology, Medical College of Wisconsin, Milwaukee.

Importance: Oral propranolol is widely considered to be first-line therapy for complicated infantile hemangioma, but its use in patients with PHACE (posterior fossa malformations, hemangioma, arterial anomalies, cardiac defects, eye anomalies) syndrome has been debated owing to concerns that the cardiovascular effects of the drug may increase the risk for arterial ischemic stroke.

Objective: To assess the incidence of adverse events among patients with PHACE syndrome receiving oral propranolol for infantile hemangioma.

Design, Setting, And Participants: This multicenter retrospective cohort study assessed the incidence of adverse events among 76 patients with PHACE syndrome receiving oral propranolol for infantile hemangioma at 11 tertiary care, academic pediatric dermatology practices. Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.3839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990697PMC
December 2019

Surgical Intervention of Periocular Infantile Hemangiomas in the Era of β-Blockers.

Ophthalmic Plast Reconstr Surg 2020 Jan/Feb;36(1):70-73

Division of Oculofacial Plastic and Reconstructive Surgery, UC San Diego Department of Ophthalmology, La Jolla, CA.

Purpose: To examine the role of adjuvant surgical resection of infantile hemangiomas after systemic β-blocker therapy.

Methods: This is a multicentered retrospective study. Standard protocol for oral propranolol was employed by the referring physicians. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001466DOI Listing
December 2019

Hemangioma: Recent Advances.

F1000Res 2019 18;8. Epub 2019 Nov 18.

Otolaryngology, Head and Neck Surgery, Arkansas Children's Hospital at the University of Arkansas for Medical Science, Little Rock, Arkansas, 72202, USA.

Hemangiomas are common benign vascular tumors that often present in childhood. Diagnosis is based on clinical history, physical examination, and, when unclear, assisted with ultrasound or MRI. While the majority are small, nonproblematic, and can be managed conservatively, some hemangiomas may be associated with underlying syndromes or concerning for visceral involvement. Read More

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http://dx.doi.org/10.12688/f1000research.20152.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871355PMC
November 2019

Hemangioma of the Maxilla.

J Craniofac Surg 2020 Mar/Apr;31(2):501-503

Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Shimotsuke, Japan.

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http://dx.doi.org/10.1097/SCS.0000000000006109DOI Listing
December 2019

Lobular Capillary Hemangioma of the Ethmoid Sinus: A Report of Two Cases.

Indian J Otolaryngol Head Neck Surg 2019 Nov 1;71(Suppl 3):1668-1671. Epub 2015 Aug 1.

4Department of ENT, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Soft-tissue tumors are rare in the paranasal region. Lobular capillary hemangioma (LCH) is a distinctive vascular lesion most commonly seen on the skin and oral mucosa in the fourth and fifth decades of life. Forasmuch as the nasal cavity and paranasal sinuses are rare locations for LCH, it is not well known by many ENT surgeons. Read More

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http://dx.doi.org/10.1007/s12070-015-0885-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848392PMC
November 2019

Oral Atenolol for Infantile Hemangioma: Case Series of 46 Infants.

Actas Dermosifiliogr 2020 Jan 20;111(1):59-62. Epub 2019 Nov 20.

Servicio de Dermatología Pediátrica, Instituto Nacional de Salud del Niño, Breña, Perú.

Propranolol, a non-selective beta-blocker, remains the first line of treatment for problematic infantile hemangioma. However, although rarely, a subset of patients experience undesirable side effects, raising interest in other selective beta-blockers. We present a large case series of 46 infants treated successfully with oral atenolol, a selective beta-1 blocker. Read More

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http://dx.doi.org/10.1016/j.ad.2019.03.015DOI Listing
January 2020

To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.

Indian J Ophthalmol 2019 12;67(12):1974-1980

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas.

Methods: Twenty patients were prospectively randomized to two groups of ten each. Group 1 was initiated on oral propranolol 1 mg/kg/day titrated to final dose of 3 mg/kg/day over 1 week which was continued for 6 months and then tapered over 1 week; Group 2 received 3 doses of direct intralesional propranolol hydrochloride 1 mg/ml; 0. Read More

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http://dx.doi.org/10.4103/ijo.IJO_59_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896529PMC
December 2019

Management of Periocular Infantile Hemangioma.

J Pediatr Ophthalmol Strabismus 2019 Nov;56(6):344-346

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http://dx.doi.org/10.3928/01913913-20190826-01DOI Listing
November 2019

Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate.

Indian J Otolaryngol Head Neck Surg 2019 Oct 4;71(Suppl 1):566-573. Epub 2018 Jun 4.

Department of Dental Surgery, VIMSAR, Burla, Odisha 768017 India.

Management of head and neck hemangiomas with oral propranolol versus oral itraconazole in conjugation with injection sodium tetra decyl sulphate. This prospective parallel clinical trial was done to check for the effectiveness of oral propranolol and oral itraconazole when used in conjugation with inj. sodium tetra decyl sulphate in treatment of head and neck haemangiomas in adult patients visiting department of ENT and head and neck surgery, VIMSAR, Burla. Read More

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http://dx.doi.org/10.1007/s12070-018-1410-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848284PMC
October 2019

Intraosseous venous malformation of the craniofacial region: diagnosis and management.

Br J Oral Maxillofac Surg 2019 12 13;57(10):1143-1147. Epub 2019 Nov 13.

University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK.

Vascular lesions mainly affect soft tissues, and less than 1% affect bone. In 1982, they were categorised by Mulliken and Glowacki as haemangiomas or vascular malformations, and an updated classification was subsequently published by the International Society for the Study of Vascular Anomalies. These lesions, however, continue to be termed haemangiomas and there is little attempt to differentiate between them. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.10.308DOI Listing
December 2019