Ear Nose Throat J 2017 Jul;96(7):240

Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, CA, USA.

Int J Pharm Compd 2017 Jul-Aug;21(4):282-289

National Skin Centre Pte. Ltd., Singapore.

The discovery of beta-adrenergic blocker effects on infantile hemangiomas has affected the choice of treatment in recent years. Oral propranolol is effective in treating infantile hemangiomas, but the risk of systemic side effects remains a concern. Data from literature review reported positive clinical outcomes with no major adverse effects observed in children using topical beta-blocker such as timolol maleate. Read More

J Craniofac Surg 2017 Jul 13. Epub 2017 Jul 13.

Division of Plastic, Aesthetic and Reconstructive Surgery. University of Miami, Leonard Miller School of Medicine, Miami, Florida.

Front Oncol 2017 27;7:137. Epub 2017 Jun 27.

Department of Interventional Therapy, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0. Read More

Pediatr Dermatol 2017 Jul 29;34(4):458-460. Epub 2017 Jun 29.

Division of Pediatric Dermatology, Children's Hospital of Wisconsin, Milwaukee, Wisconsin.

Background/objectives: Topical timolol maleate solution or gel-forming solution is used alone or in conjunction with oral propranolol for the treatment of infantile hemangiomas. The consistency of the amount of timolol dispensed has never been evaluated. We evaluated the variability of drug delivery between different brands and formulations of timolol solution and gel-forming solution. Read More

Am J Otolaryngol 2016 Nov 23. Epub 2016 Nov 23.

Department of Pathology, Louisiana State University Health Science Center, Shreveport, LA 71130, USA.

Oral foregut duplication cysts are extremely rare lesions with approximately 57 cases reported. They are congenital cysts, located in the anterior or ventral tongue, and occur predominantly in males. They are lined by one or more types of epithelia which is limited to gastric, intestinal or respiratory epithelium. Read More

Exp Ther Med 2017 Jun 5;13(6):2645-2650. Epub 2017 Apr 5.

Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.

Treatment of infantile hemangiomas (IH) with propranolol was first reported in 2008. Regressions of lymphatic malformations combined with pulmonary hypertension was first reported in 2012 after three children received treatment with oral sildenafil, which serves as an antagonist of phosphodiesterase isoform-5 (PDE-5). A marked expression of endothelial cells in the cytoplasm of IH tissues was obtained in our previous study. Read More

Indian J Dermatol 2017 May-Jun;62(3):237-250

Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.

Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullous pemphigoid. Read More

J Med Case Rep 2017 Jun 2;11(1):149. Epub 2017 Jun 2.

Department of Pediatric Surgery, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India.

Background: Myoepitheliomas account for less than 1% of salivary gland tumors. They mostly affect the parotid glands of adults during the third to fifth decades.

Case Presentation: A 10-year-old Indian boy reported a small swelling in the roof of his mouth of 10 days' duration. Read More

Contemp Clin Dent 2017 Jan-Mar;8(1):185-187

Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.

Hemangioma is a benign vascular tumor that affects 3%-10% of the population and usually does not require specific treatment due to spontaneous regression. The purpose of this paper is to present a case report of a child having been born prematurely and diagnosed with hemangioma in the head and neck, emphasizing the dentofacial changes and treatment used to provide care. Severe fibrous scars were found in the perioral region and below the ear that limited the patient's ability to open her mouth. Read More

Exp Mol Pathol 2017 May 22;103(1):9-13. Epub 2017 May 22.

Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Objectives: To evaluate cases diagnosed as "oral hemangiomas" based on the immunohistochemical expression of human glucose transporter protein (GLUT-1) and on histopathological features, and to investigate whether the classification proposed by the ISSVA was used correctly to classify these lesions.

Material And Methods: All cases stored in the archives of an Oral Pathology Service and diagnosed as "oral hemangiomas" were reviewed. Seventy-seven cases were analyzed regarding the expression of GLUT-1. Read More

Eur J Radiol Open 2017 14;4:63-68. Epub 2017 May 14.

Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Objectives: Vascular anomalies are included in the 30 000 rare diseases worldwide affecting less than 5/10 000 people. Depending on their morphology and biological properties, they can cause varied disorders with organ involvement. Almost 60% of vascular anomalies have a predilection for the head and neck region in children. Read More

Craniomaxillofac Trauma Reconstr 2017 Jun 16;10(2):166-170. Epub 2017 Mar 16.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Various forms of vascular lesion affect the head and neck region. The head and neck vascular lesions are classified into neoplasms and malformations. Neoplasm presents either as hemangioma or lymphangioma; neoplasm usually presents in young age compared with vascular malformation. Read More

Drug Des Devel Ther 2017 8;11:1401-1408. Epub 2017 May 8.

Department of Oral-Maxillary Head and Neck, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai.

Objective: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas. Read More

JAMA Facial Plast Surg 2017 Jul;19(4):327-332

Hemangioma and Malformation Treatment Center, Charleston, South Carolina.

Importance: Current treatment approaches for infantile hemangiomas of the nose include observation, pharmacologic agents, surgery, and/or laser therapy. Because of the known functional, social, and cosmetic effect of nasal deformities, obtaining the best possible result is critical. Optimal timing, type, duration, and extent of therapy remain unclear. Read More

J Craniofac Surg 2017 Jun;28(4):e398-e399

*Department of Pathology, Faculty of Medicine †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep ‡Department of Pathology, Faculty of Medicine, TOBB Economics and Technology, Ankara, Turkey.

Metastatic tumors rarely occur in the oral cavity. The most common of the oral metastases are lung cancers in males, and breast and genital cancers in females. The most common primary tumor metastasis to the oral cavity is from the lung, kidney, liver, prostate, and colorectal cancers. Read More

J Korean Assoc Oral Maxillofac Surg 2017 Apr 25;43(2):125-133. Epub 2017 Apr 25.

Department of Pathology, Inha University School of Medicine, Incheon, Korea.

Intramuscular hemangioma (IMH) is a rare vascular disease involving skeletal muscle, comprising only 0.8% of hemangiomas. About 10% to 15% of IMHs occur in the head and neck region, mostly involving the masseter muscle. Read More

Pediatr Int 2017 Apr 28. Epub 2017 Apr 28.

Maruho, Kyoto, Japan.

Background: There have been few reports on the efficacy and safety of oral propranolol at 3 mg/kg/day for infantile hemangioma (IH) in Japanese patients.

Methods: A multicenter, open-label phase III study was conducted to evaluate the efficacy and safety of oral propranolol solution in Japanese infants aged 35-150 days with proliferating IH. Thirty-two patients were enrolled in the study, received propranolol solution for 24 weeks at 3 mg/kg/day, and completed the study. Read More

J Histochem Cytochem 2017 May 1;65(5):285-294. Epub 2017 Feb 1.

The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education (H-FX, J-YZ, J-NW, J-GR, YC, F-QW, WZ, GC, Y-FZ, J-HZ), School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Accumulating studies have revealed the hypoxic condition and its crucial role in the distinctive progression of infantile hemangioma (IH), the most common benign tumor in infancy. Activating transcription factor 4 (ATF4), an important gene mediating cellular adaptation to various stress signals, could confer a survival advantage for tumor cells under hypoxia and regulate tumor progression. However, the potential role of ATF4 in IH was still unknown. Read More

Ital J Pediatr 2017 Apr 19;43(1):40. Epub 2017 Apr 19.

Angioma Center, Cardiovascular Department, Gaslini Children's Research Institute, Genoa, Italy.

Background: Despite not being licensed for the treatment of infantile hemangiomas (IH) in infants younger than 5 weeks or older than 5 months, propranolol is often used in these age groups to prevent or to treat potentially severe complications. The objective of the present study was to review the experience of 8 Italian pediatric and dermatologic centers regarding propranolol treatment for IH started before 5 weeks or after 5 months of age.

Methods: We retrospectively reviewed the records of patients followed up for IH, on propranolol treatment started before 5 weeks or after 5 months of age, and collected information on sociodemographic data, treatment indications, IH involution, IH relapse, and treatment side effects. Read More

J Oral Maxillofac Surg 2017 Mar 22. Epub 2017 Mar 22.

Staff, Vascular Birthmark Institute of New York, Department of Otolaryngology, Lenox Hill and Manhattan Eye, Ear, and Throat Hospitals, New York, NY; Assistant Clinical Professor, Department of Ophthalmology, Harvard Medical School, Boston, MA. Electronic address:

Purpose: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. Read More

J Stomatol Oral Maxillofac Surg 2017 Apr 5. Epub 2017 Apr 5.

Grenoble University Hospital, Department of Maxillo-facial Surgery, Avenue Maquis du Grésivaudan, 38700 La Tronche, France.

Nasal glial heterotopia (NGH) is a rare benign tumor of the median line. We describe the case of a child presenting a lateral nasal mass. The characteristics of the prenatal ultrasound and the postnatal clinical examination argued in favor of a congenital hemangioma (CH). Read More

J Cosmet Laser Ther 2017 Apr 7:1-3. Epub 2017 Apr 7.

a Hospital Federal da Lagoa , Rio de Janeiro , Brazil.

Vascular lesions such as hemangiomas can be found in the oral cavity. Some therapeutic modalities can be used in the treatment of these lesions and Nd:YAG 1064 nm long pulse laser shows good results with easy application, fewer complications and satisfactory results. This study describes the technique and outcome of a case of hemangioma located on the tongue treated with Nd:YAG laser. Read More

Sci Rep 2017 Mar 23;7(1):342. Epub 2017 Mar 23.

Department of Oral and Maxillofacial Surgery, Qilu Hospital, and Institute of Stomatology, Shandong University, Jinan, 250012, China.

Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2. Read More

Case Rep Dermatol 2016 Sep-Dec;8(3):369-373. Epub 2016 Dec 22.

Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.

Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. Read More

Neuropediatrics 2017 Mar 16. Epub 2017 Mar 16.

Unité de Neurologie Pédiatrique, Hôpital des Enfants, CHU Purpan, Toulouse, France.

A 21-day-old male infant was admitted with signs of intracranial hypertension. Brain magnetic resonance imaging (MRI) revealed a voluminous mass in the posterior fossa with an intense peripheral enhancement on T1 images with gadolinium. The child was treated secondarily by surgical decompression of the posterior fossa and the lesion was biopsied. Read More

No Shinkei Geka 2017 Mar;45(3):219-224

Department of Neurosurgery, Faculty of Medicine, Saga University.

Taste(gustation)is one of the five senses, and comprises the types: sweet, bitter, salty, sour, and umami. Taste disorders, such as dysgeusia and parageusia, are classified into 2 types: those with peripheral origin and those with central origin. The peripheral origin-type taste disorder is caused by zinc deficiency, mouth dryness, a side effect of radiotherapy or complication of systemic diseases such as, diabetes, hepatopathy, and nephropathy. Read More

Shanghai Kou Qiang Yi Xue 2016 Dec;25(6):744-747

Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.

Non-selective β-blocker propranolol has been proved by FDA as the first-line agent for infantile hemangioma (IH) with dramatic response. To reduce the side effects caused by systemic administration of propranolol, timolol maleate treatment has been increasingly used as an alternative to systemic β-blockers and watchful waiting for many IH patients in recent years. However, the appropriate indications, drug dosage, dosing regimen, time for initiation, optimal duration, monitoring for side effects still remains controversial. Read More

Australas J Dermatol 2017 May 1;58(2):155-159. Epub 2017 Mar 1.

Royal Children's Hospital, Melbourne, Victoria, Australia.

Although most infantile haemangiomas do not require treatment due to a natural history of spontaneous involution, some require early intervention. The Australasian Vascular Anomalies Network and the Australasian Paediatric Dermatology Network have developed a consensus statement for the treatment of infantile haemangiomas with oral propranolol. Infants with haemangiomas that are life threatening, at risk of ulceration, or at risk of causing a significant functional impairment, psychological impact or physical deformity should be treated early with oral propranolol. Read More

Sci Rep 2017 Feb 22;7:43292. Epub 2017 Feb 22.

From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Read More

J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.

Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

Craniomaxillofac Trauma Reconstr 2017 Mar 4;10(1):1-10. Epub 2016 Nov 4.

Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Intraosseous hemangiomas are uncommon intrabony lesions, representing approximately 0.5 to 1% of all intraosseous tumors. Their description varies from "benign vasoformative neoplasms" to true hamartomatous proliferations of endothelial cells forming a vascular network with intermixed fibrous connective tissue stroma. Read More

J Oral Maxillofac Surg 2017 Jan 5. Epub 2017 Jan 5.

Professor, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University, Jeonju, Korea; and Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. Electronic address:

Purpose: Hemangioma is a common benign vascular lesion of the head and neck region. It rarely involves the mucous membranes of the nasal cavity and paranasal sinuses. It should be added to the differential diagnosis of nasal cavity masses when the presenting symptoms are epistaxis or nasal obstruction. Read More

J Clin Exp Dent 2017 Jan 1;9(1):e153-e156. Epub 2017 Jan 1.

MD, Specialist Doctor of Medicine; Ministry of Health Turkish Public Hospitals Institution Association of Antalya Public Hospitals Serik State Hospital, Department of Pathology, Antalya/Turkey.

Intraosseous vascular lesions are rare conditions. They are most commonly seen in the vertebral column and skull; nevertheless, the mandible is a quite rare location. In this report, we present a case of intraosseous cavernous hemangioma in the mandible and discuss the clinical and radiological features. Read More

J Cutan Pathol 2017 May 16;44(5):451-455. Epub 2017 Feb 16.

School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.

Background: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In this study, vascular lesions occurring in the lips were retrieved from an Oral Pathology Service.

Methods: Among 5600 biopsies, 131 cases were found. Read More

Lancet 2017 07 13;390(10089):85-94. Epub 2017 Jan 13.

Departments of Paediatrics and Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.

With a prevalence of 4·5%, infantile haemangiomas are the most common benign tumours of infancy, arising in the first few weeks of life and exhibiting a characteristic sequence of growth and spontaneous involution. Most infantile haemangiomas do not require therapy. However, to identify at-risk haemangiomas, close follow-up is crucial in the first weeks of life; 80% of all haemangiomas reach their final size by 3 months of age. Read More

Indian Pediatr 2016 Dec;53(12):1103-1104

Departments of Otorhinolaryngology and Head and Neck Surgery, and *Pathology, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India. Correspondence to: Dr Divya Gupta, Department of Otolaryngology and Head and Neck Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.

Background: Primary osseous hemangiomas of the facial skeleton mimic malignancy. Their location in maxillary sinus, especially in infants is extremely rare.

Case Characteristics: 1- month-old full term boy with maxillary swelling. Read More

J Dermatolog Treat 2017 Jan 11:1-8. Epub 2017 Jan 11.

a Department for Cardiology , University Children's Hospital Tirsova , Belgrade , Serbia.

Purpose: Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication.

Materials And Methods: Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Read More

Matrix Biol 2016 Dec 20. Epub 2016 Dec 20.

Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, United States; Department of Oral and Maxillofacial Surgery/Skeletal Biology Research Center, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA, United States. Electronic address:

Our previous studies of Antxr1 knockout mice suggested that fibrotic skin abnormalities in these mice are associated with increased VEGF signaling. Here, based on studies of primary fibroblasts isolated from skin of Antx1+/+ and Antxr1-/- mice at embryonic stage E17.5 and postnatal day P49, we conclude that increased Col1a1 and Fn1 expression in Antxr1-deficient fibroblasts is partly mediated by a cell-autonomous ANTXR1-dependent mechanism. Read More

Maxillofac Plast Reconstr Surg 2016 Dec 25;38(1):44. Epub 2016 Nov 25.

Department of Oral & Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 South Korea.

Background: Hemangioma and vascular malformation are benign vascular lesions that often occur in cephalic and cervical region. Currently, surgical resection, laser therapy, angiographic embolization, use of steroids, and sclerotherapy are used as treatments.

Case Presentation: This study reports three cases of benign vascular lesions that are remarkably treated by sodium tetradecyl sulfate (STS) injection, of which occurred in oral cavity and around the mouth. Read More

Case Rep Dent 2016 23;2016:4320102. Epub 2016 Nov 23.

Department of Oral Surgery, Medical Faculty, University of Prishtina, Dental Branch, 10000 Prishtina, Kosovo.

Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. Read More

J Clin Exp Dent 2016 Dec 1;8(5):e638-e644. Epub 2016 Dec 1.

Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.

Acinic cell carcinoma (ACC) is a malignant tumor of the salivary glands. The majority of ACCs occur in the parotid gland, and ACCs of the minor salivary glands (MSGs) are relatively infrequent. We describe here a patient with ACC of the upper lip. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan 15;123(1):e16-e21. Epub 2016 Oct 15.

Oral Diagnosis Department, Semiology and Oral Pathology, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Sao Paulo, Brazil. Electronic address:

Intramuscular nodules can be the clinical presentation of several groups of lesions, such as reactive disorders and benign and malignant tumors. Here, we present three cases with similar clinical features and image aspects on Doppler ultrasonography. Two of the lesions were diagnosed as intramasseteric hemangioma and the third as intramasseteric metastasis from high-grade pleomorphic sarcoma of the thigh. Read More

J Oral Biol Craniofac Res 2016 Nov 26;6(Suppl 1):S58-S61. Epub 2015 Sep 26.

Reader, Department of Periodontology, People's Dental Academy, Bhopal, India.

Due to its location, intra-masseteric venous malformation often mistaken for a parotid swelling and clinical examination alone frequently underestimates the deep extension of the lesion and rarely gives accurate pre-operative diagnosis. But once it is diagnosed, the feasibility of the treatment and the plan of approach depend on accurate delineation of the extent, size and location of the lesion. Therefore, complimentary radiographic studies are essential for its management. Read More

Ann Ital Chir 2016 Oct 14;2578. Epub 2016 Oct 14.

Introduction: Hemangiomas are very commonly diagnosticated in childhood. The area most affected by this disease is the head and neck. In recent decades, the laser therapy has changed the treatment of hemangiomas through special techniques with advantages in bleeding risk management. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2016 Nov;18(11):1154-1157

Department of Dermatology, Hunan Children's Hospital, Changsha 410007, China.

A two-month-old boy visited the hospital due to unexpected cutaneous purpura and thrombocytopenia for 2 days. The physical examination revealed a purple mass on the back. The soft tissue color Doppler ultrasound showed rich blood signals in the tissue, and the results of bone marrow puncture indicated an increased number of megakaryocytes. Read More

J Oral Maxillofac Surg 2016 Nov 2;74(11):2193-2199. Epub 2016 May 2.

Professor and Chairman, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China. Electronic address:

Purpose: Periorbital infantile hemangiomas (IHs) require early intervention because they have the potential risk of causing visual disturbances. In recent years, propranolol has shown promise in the effective management of periocular and periorbital IHs. The objective of our study was to assess the clinical outcomes, efficacy, and safety of propranolol in the management of infants with high-risk periorbital IHs. Read More

J Cutan Pathol 2016 Nov 19;43(11):1025-1027. Epub 2016 Aug 19.

Oral and Maxillofacial Department, Royal United Hospital Bath, Bath, UK.

Background: Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor that rarely occurs in the mouth.

Methods And Results: We present an SCH arising in the tongue of a 52-year-old otherwise healthy woman. SCH should be considered in the differential diagnosis of vascular tumors in the oral cavity and not misinterpreted as a more aggressive vascular tumor. Read More

Drugs Real World Outcomes 2016 Mar;3(1):25-31

Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana, Mexico.

Background: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors.

Objective: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol. Read More

Pediatrics 2016 Oct;138(4)

Pierre Fabre Dermatologie, Lavaur, France.

Background And Objectives: Given the widespread use of propranolol in infantile hemangioma (IH) it was considered essential to perform a systematic review of its safety. The objectives of this review were to evaluate the safety profile of oral propranolol in the treatment of IH.

Methods: We searched Embase and Medline databases (2007-July 2014) and unpublished data from the manufacturer of Hemangiol/Hemangeol (marketed pediatric formulation of oral propranolol; Pierre Fabre Dermatologie, Lavaur, France). Read More