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J Stomatol Oral Maxillofac Surg 2022 Apr 26. Epub 2022 Apr 26.

Praticien hospitalier du service de chirurgie maxillo-faciale et orale de l'hôpital Saint-Joseph, Paris, France.

Granular cell tumors are rare tumors with multiple localizations. The most common localizations are in the cervicofacial region in 45-65% of cases. The characterization of this tumor depends on its clinical and histopathological findings. Read More

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S77-S79. Epub 2022 Feb 28.

Department of Laboratory of Lasers in Dentistry (LELO), University of Sao Paulo (USP), Brazil.

Congenital epulis (CE) is a rare condition in newborns, whose histogenesis remains unclear. It mostly presents as a circumscribed mass in the maxilla alveolar ridge of female neonates and can interfere with their normal breathing and breastfeeding. This benign oral lesion usually appears as a pedunculated nodule covered with normal mucosa that extends from the anterior vestibular alveolar ridge up to the posterior region. Read More

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S91-S95. Epub 2022 Feb 28.

Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana, India.

Small cell neuroendocrine carcinoma (SNEC) was first described in the 19 century which is usually seen in association with lung cancer and is very rare in the oral cavity. Here, we report one such case in a 39-year-old male patient who presented with swelling on the left middle third of the face for 6 months. This is the 12 SNEC of oral cavity case so far reported in the English literature and the third case to be present on buccal mucosa. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2022 Apr;57(4):410-414

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To provide references for the diagnosis and treatment of congenital granular cell tumor (CGCT), by comprehensive analysis of the clinical data, histopathological and immunohistochemical results. Patients with CGCT were involede, from March 2015 to November 2020, at the Department of Oral and Maxillofacial Surgery of the First Affiliated Hospital of Zhengzhou University. A total of 6 children, aged 3-16 days, 1 male and 5 female, 5 maxillary and 1 mandibular, with maximum tumor diameter of 6-70 mm, were included. Read More

Dent J (Basel) 2022 Mar 4;10(3). Epub 2022 Mar 4.

Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.

Granular cell tumours (GCTs) are rare submucosal lesions, thought to develop from Schwann cells, characterised by large polygonal cells with abundant lysosomes. The objectives of this study are to investigate whether GCTs have an antigen-presenting cell (APC) phenotype or a neural crest phenotype using immunohistochemistry and to compare expression profiles with Schwannomas. Immunoreactivity to CD68, HLA-DR, CD163, CD40 and CD11c (APC phenotype) and markers of neural crest cell (NCC) origin S100, SOX10, NSE and GAP43 in 23 cases of GCTs and 10 cases of Schwannomas were evaluated. Read More

Clin Case Rep 2022 Mar 13;10(3):e05580. Epub 2022 Mar 13.

Department of Oral and Maxillofacial Surgery KIST Medical College and Teaching Hospital Kathmandu Nepal.

Congenital granular cell tumor (CGCT) is a rare benign lesion and presents as a fibrous mass arising from the alveolus in the newborn. The prenatal screening of lesions can help in parent counseling, determining the complications, as larger size lesions may interfere with normal delivery and require a cesarean section. Read More

Int J Environ Res Public Health 2022 02 25;19(5). Epub 2022 Feb 25.

Department of Oral and Maxillofacial Surgery, Ruhr University Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany.

Background: Hypoglossal nerve palsy (HNP) is rather common as a neurological disease. However, as an isolated nerve palsy it is an exceedingly rare phenomenon and points at local pathologies along the peripheral course of the nerve. In this communication we report a granular cell tumor (GCT) arising in the submandibular segment of the hypoglossal nerve. Read More

BMC Oral Health 2022 03 5;22(1):61. Epub 2022 Mar 5.

Student Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Granular cell odontogenic tumor (GCOT) is a rare neoplasm with about 45 cases reported in the literature. It usually occurs in the posterior mandible of middle-aged women.

Case Presentation: We report a case of asymptomatic GCOT in the posterior mandible of a 28 years old female and provide a literature review of GCOT cases. Read More

Int J Surg Case Rep 2022 Mar 17;92:106844. Epub 2022 Feb 17.

Department of Surgery, Section of Otolaryngology, University of Chicago Medicine, Chicago, IL, USA. Electronic address:

Introduction: Granular cell tumors (GCT) are rare tumors that most frequently present in the oral cavity. While some present within the gastrointestinal tract, a GCT near the trachea is an extremely rare occurence.

Presentation Of Case: A 42-year-old man presented to the Emergency Department after a motor vehicle accident. Read More

Clin Ter 2022 Feb;173(1):35-38

University of Hargheisa-Somaliland.

Case Report: A 14-year-old girl presented with 1 cm large whitened lesion on the ventral surface of the tongue, appeared from 1 month. Past history showed congenital dyserythropoietic anemia type II. The lesion was excised and microscopic and immunohistochemical analyses were compatible with benign Abrikossoff tumor. Read More

S D Med 2021 Nov;74(11):528-531

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Granular cell tumors (GCT) are benign, submucosal tumors derived from neural or Schwann cells. They are commonly found in the oral cavity, skin, breast and tongue. Less commonly, they can also occur in the gastrointestinal tract, usually in the esophagus. Read More

BMJ Case Rep 2022 Jan 4;15(1). Epub 2022 Jan 4.

Department of Pediatric and Preventive Dentistry, Amrita Vishwa Vidyapeetham Amrita School of Dentistry, Kochi, Kerala, India.

Congenital granular cell epulis is a congenital growth rarely found on the gingiva of neonates. These remarkably large tumours present in an infant's mouth may impede with feeding, respiration or adequate mouth closure. Recognition of this entity and prompt treatment are essential for preventing any difficulties for the neonate. Read More

Int J Mol Sci 2021 Dec 17;22(24). Epub 2021 Dec 17.

Department of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Avenue, 119571 Moscow, Russia.

Photodynamic therapy (PDT) is currently one of the most promising methods of cancer treatment. However, this method has some limitations, including a small depth of penetration into biological tissues, the low selectivity of accumulation, and hypoxia of the tumor tissues. These disadvantages can be overcome by combining PDT with other methods of treatment, such as radiation therapy, neutron capture therapy, chemotherapy, etc. Read More

J Indian Soc Periodontol 2021 Nov-Dec;25(6):544-548. Epub 2021 Nov 1.

Department of Ophthalmology, Lady Hardinge Medical College and Associated Hospitals, University of Delhi, New Delhi, India.

Granular cell tumor (GCT) of the oral cavity is rare and so is the involvement of the eye, orbit, and ocular adnexa. A 65-year-old male developed a posttraumatic ulceroproliferative mass over his left cheek for the past 1 year. The mass involved the periorbital region with accompanying blood-stained purulent discharge from multiple sinus tracts over this lesion for the past 6 months. Read More

J Int Med Res 2021 Oct;49(10):3000605211053769

Department of Neonatology, Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, Sichuan Province, China.

Congenital granular cell epulis (CGCE) is a rare benign soft tissue lesion that usually originates from the neonatal gingiva and can lead to difficulty in breathing and feeding upon birth. This current case report describes a female newborn with a gingival mass that was identified by prenatal fetal ultrasonography. At birth, the oral mass was observed to protrude from the mouth, which adversely affected feeding. Read More

Gen Dent 2021 Nov-Dec;69(6):54-57

The objective of this case report is to describe a congenital epulis of the newborn. A 10-day-old female neonate was brought to a dental clinic for examination of an intraoral lesion that was present at birth. No systemic changes were noted during the extraoral examination. Read More

Blood 2021 12;138(26):2828-2837

Department of Pathology.

Signaling through JAK1 and/or JAK2 is common among tumor and nontumor cells within peripheral T-cell lymphoma (PTCL). No oral therapies are approved for PTCL, and better treatments for relapsed/refractory disease are urgently needed. We conducted a phase 2 study of the JAK1/2 inhibitor ruxolitinib for patients with relapsed/refractory PTCL (n = 45) or mycosis fungoides (MF) (n = 7). Read More

BMJ Case Rep 2021 Sep 20;14(9). Epub 2021 Sep 20.

Oral and Maxillofacial Surgery, Royal Perth Hospital, Perth, Western Australia, Australia.

Granular cell tumour (GCT) is a rare soft tissue lesion which many consider to have malignant potential of yet unknown aetiopathogenesis. Oral GCT lesions may occur in an area of leucoplakia and are predominantly present on the tongue. This case study highlights an uncommon presentation of this condition located on the buccal mucosa and illustrates the need for meticulous evaluation of suspicious lesions. Read More

Pathologica 2021 Aug;113(4):280-284

Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.

Congenital granular cell epulis is a rare benign lesion usually arising as single mass from the alveolar ridge of maxillary bone of female newborns, composed of polygonal granular cells that typically stain negative for S-100, in contrast to the adult counterpart. Larger lesions can disturb breathing and breast-feeding, requiring surgery. Prenatal diagnosis is achieved in few cases, even if this would be important for best management of delivery and therapy. Read More

J Clin Pediatr Dent 2021 Oct;45(4):269-272

Congenital granular cell lesion (CGCL) is a rare benign oral cavity tumor in infants. Neonatal teeth are also rare dental anomalies that appear during the first month of life. This report describes a case of eruption of neonatal teeth after surgical excision of CGCL. Read More

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S68-S71. Epub 2021 Jun 5.

Department of ENT, SMBT Institute of Medical Science and Research Centre, Nashik, Maharashtra, India.

Background: Soft tissues of the head and neck areas are a very frequent site of occurrence of certain benign tumors of the peripheral nerve sheath, especially the neurofibromas. Hence, the present study was conducted for assessing clinical, radiographic, and treatment profile of 10 cases of neurogenic tumors and tumor-like lesions of the oral and maxillofacial region.

Materials And Methods: Data records of a total of 10 patients who were diagnosed with tumors of neurogenic origin were enrolled in the present study. Read More

Int J Clin Pediatr Dent 2021 Mar-Apr;14(2):319-322

Department of Pediatric Dentistry, Chettinad Dental College and Research Institute, Kancheepuram, Tamil Nadu, India.

Aim And Objective: To give dental practitioners an insight into the unusual presentation of focal infantile hemangioma on the alveolar ridge showing immunoreactivity to glucose transporter-1 (GLT1). We also recommend the importance of using standardized terminologies to describe the type of hemangioma.

Background: One of the most commonly seen and misdiagnosed vascular tumors of the skin and soft tissues of the head and neck region in children are infantile hemangiomas. Read More

Cancer Cytopathol 2021 12 11;129(12):973-983. Epub 2021 Aug 11.

Department of Pathology, Ohio State University Wexner Medical Center/James Cancer Hospital/Richard Solove Research Institute, Columbus, Ohio.

Background: Although largely readily recognizable in tissue sections, acinic cell carcinoma (ACC) remains diagnostically problematic in fine-needle aspiration (FNA) cytopathology. The authors undertook an analysis of a large series of ACC aspirates, including acinic cell carcinoma with high-grade transformation (ACC-HGT).

Methods: The authors searched their cytopathology files for ACC cases with histopathologic confirmation. Read More

Case Rep Dent 2021 17;2021:2093927. Epub 2021 Jul 17.

Department of Conservative Dentistry and Endodontics, Al-Badar Dental College and Hospital, Kalaburgi, Karnataka, India.

Ameloblastoma is an epithelial odontogenic neoplasm with clinical and histological diversity. They are locally invasive tumors with 3 clinical variants such as solid, unicystic, and peripheral ameloblastomas, and the unicystic variant constitutes only 13%. Histologically, it shows diverse microscopic patterns that may occur isolated or in combination with other patterns. Read More

Transl Pediatr 2021 May;10(5):1386-1392

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of General and Emergency Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Congenital granular cell tumour (CGCT) is a benign lesion that predominantly arises from the alveolar ridges of neonates, especially the maxilla. However, it's only 10 percent of multiple lesions in all reported cases, in which simultaneously mandibular and maxillary involvements are more extremely rare. For treatments of multiple CGCTs, few standard procedures were reported. Read More

J Dent Sci 2021 Jul 18;16(3):1018-1019. Epub 2021 Feb 18.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S94-S98. Epub 2021 Mar 19.

Department of Oral Pathology and Microbiology, Mar Baselios Dental College, Kothamangalam, Kerala, India.

Squamous odontogenic tumor (SOT) is a rare benign neoplasm and may be located to multiple sites in the oral cavity mouth. As per the literature, there have been <50 reported cases. The tumor is often asymptomatic, although it can present with symptoms of pain and tooth mobility. Read More

Int J Appl Basic Med Res 2021 Apr-Jun;11(2):111-113. Epub 2021 Apr 8.

Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Granular cell tumor (GCT) is a rare benign tumor chiefly affecting the orofacial region, especially tongue. The origin of this neoplasia, after remaining a controversy for years, was finally identified to be from Schwann cell or neuroendocrine cell. They usually present as asymptomatic, firm, sessile, submucosal, solitary, or multiple nodule/papule like lesions. Read More

Head Neck Pathol 2021 Mar 15;15(1):71-84. Epub 2021 Mar 15.

Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

This article reviews odontogenic and developmental oral lesions encountered in the gnathic region of pediatric patients. The process of odontogenesis is discussed as it is essential to understanding the pathogenesis of odontogenic tumors. The clinical presentation, microscopic features, and prognosis are addressed for odontogenic lesions in the neonate (dental lamina cysts/gingival cysts of the newborn, congenital (granular cell) epulis of the newborn, melanotic neuroectodermal tumor, choristoma/heterotopia, cysts of foregut origin), lesions associated with unerupted/erupting teeth (hyperplastic dental follicle, eruption cyst, dentigerous cyst, odontogenic keratocyst/keratocystic odonogenic tumor, buccal bifurcation cyst/inflammatory collateral cyst) and pediatric odontogenic hamartomas and tumors (odontoma, ameloblastic fibroma, ameloblastoma, adenomatoid odontogenic tumor, primordial odontogenic tumor). Read More

J Int Med Res 2021 Jan;49(1):300060520982689

Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Granular cell tumors (GCTs) are rare submucosal neoplasms, with tumors in the oral mucosa accounting for about a third of all cases. In contrast, GCT is a rare anal neoplasm, with fewer than 30 cases of perianal GCT reported in the literature. We report the case of a 36-year-old woman with a perianal lump with no obvious local lesion as the main clinical complaint. Read More