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    A rare case of perianal granular cell tumor: case report and literature review.
    J Surg Case Rep 2017 Jun 6;2017(6):rjw186. Epub 2017 Jun 6.
    Department of Surgery, Boca Raton Regional Hospital, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
    Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. Read More

    Granular cell ameloblastoma.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):183
    Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
    A 42-year-female patient presented with a swelling on the left side of the face for the past 10 years. The radiograph shows multilocular radiolucency with evidence of root resorption. Histopathology reveals fibrous connective tissue exhibiting numerous odontogenic epithelial islands with peripheral tall columnar cells showing a reversal of polarity. Read More

    2-Year animal carcinogenicity results for crisaborole, a novel phosphodiesterase 4 inhibitor for atopic dermatitis.
    J Dermatol Sci 2017 Mar 30. Epub 2017 Mar 30.
    Anacor Pharmaceuticals, Inc., 1020 E Meadow Circle, Palo Alto 94303, CA, USA.
    Background: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis.

    Objective: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole.

    Methods: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks. Read More

    Congenital Gingival Granular Cell Tumor: A Case Report.
    J Dent (Shiraz) 2017 Mar;18(1):70-72
    Dept. of Pathology, Gulhane Education and Research Hospital, Ankara, Turkey.
    The congenital gingival granular cell tumor (CGCT), also as known as congenital epulis, is an unusual benign oral mucosal lesion in newborns. A two-day-old female patient was admitted to the Department of Pediatric Dentistry at Gulhane Medical Academy, Ankara, Turkey with her family, and an intraoral examination showed a CGCT located in the buccal region of the maxillary right first primary molar. In this report, we present a case of CGCT in a newborn. Read More

    Granular cell tumor mimicking a squamous cell carcinoma of the tongue: a case report.
    BMC Res Notes 2017 Jan 3;10(1):14. Epub 2017 Jan 3.
    Department of Oral Medicine (Oral Pathology), Dental School, Faculdade de Odontologia, Universidade Federal de Goiás, Praça Universitária, S/N, Setor Universitário, Goiânia-Goiás, CEP 74605-220, Brazil.
    Background: Granular cell tumor is a rare benign tumor that can present a pseudoepitheliomatous hyperplasia of the covering epithelium. This lesion is not encapsulated and can be characterized by a pseudo invasive growth pattern, represented by the tumoral cells that infiltrate between adjacent connective tissue elements. Diagnostic difficulties may arise because histopathological features of the pronounced pseudoepitheliomatous hyperplasia can be confused with a well-differentiated oral squamous cell carcinoma. Read More

    Oncocytic Pleomorphic Adenoma of Palatal Salivary Gland with Macrophages and Giant Cells Associated with Cholesterol Crystals.
    Clin Pract 2016 Oct 24;6(4):884. Epub 2016 Oct 24.
    Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University , Saudi Arabia.
    Pleomorphic adenoma (PA) is the most common salivary gland tumor characterized by histo-morphological diversity in the form of myxoid, hyalinized, chondroid, osseous, and squamous areas. In this paper, we report a rare case of predominantly oncocytic variant of PA in a 45-year-old male patient on the posterior palatal region. Microscopic examination showed homogenous eosinophilic cellular mass composed of epithelial components arranged in the form of tubular and solid patterns. Read More

    Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect.
    Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e31-e35. Epub 2017 Jan 1.
    Av. Professor Lineu Prestes, 2227, Cidade Universitária, 05508-000- São Paulo, SP, Brazil,
    Background: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses. Read More

    Esophageal Granular Cell Tumor: A Case Report and Review of Literature.
    Cureus 2016 Sep 14;8(9):e782. Epub 2016 Sep 14.
    Department of Gastroenterology, Staten Island University Hospital.
    Granular cell tumors (GCTs) are soft tissue neoplasms that originate from Schwann cells. They occur predominantly in the oral cavity, skin, and breast tissues. Gastrointestinal GCTs are very rare, accounting for only eight percent of all GCTs, most of which are located in the esophagus. Read More

    S-100 Negative Granular Cell Tumor (So-called Primitive Polypoid Non-neural Granular Cell Tumor) of the Oral Cavity.
    Head Neck Pathol 2016 Oct 5. Epub 2016 Oct 5.
    Department of Oral and Maxillofacial Surgery, University of Washington School of Dentistry, B-204 Magnuson Health Sciences Center, 1959 NE Pacific Street, Box 357133, Seattle, WA, 98195, USA.
    Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Read More

    An infrequent histopathological subtype of ameloblastoma: Adenoid granular cell ameloblastoma with dentinoid.
    Dent Res J (Isfahan) 2016 Jul-Aug;13(4):376-8
    Department of Oral and Maxillofacial Radiology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
    Adenoid ameloblastoma with dentinoid is a rare odontogenic tumor. Granular cell ameloblastoma also is a less common histological subtype of ameloblastoma. In this report, the patient was a 31-year-old male. Read More

    A study of cell proliferation using immunohistological staining: A case report of congenital granular cell epulis.
    Int J Pediatr Otorhinolaryngol 2016 Sep 30;88:58-62. Epub 2016 Jun 30.
    Department of Physical Therapy, Baltimore City Community College, Baltimore, MD, USA.
    An unusual case of a 1-day-old Chinese female neonate with a solid tumor mass in the maxillary anterior ridge of the edentulous jaw is reported. Based on the clinical and histopathological features, the diagnosis was of obstructive congenital granular cell epulis (CGCE) which is an uncommon benign tumor that preferentially develops in female infants. Immunohistochemical analysis of the lesion was performed and the rate of cell proliferation was determined by immunostaining with Ki-67 and PCNA, which showed labeling indexes of 11. Read More

    Neurogenic tumors and tumor-like lesions of the oral and maxillofacial region: A clinicopathological study.
    Saudi Dent J 2016 Apr 10;28(2):76-9. Epub 2016 Feb 10.
    Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
    Objective: Oral and maxillofacial lesions of neural origin are rare soft tissue neoplasms. The aim of the present study is to review the epidemiological data of oral and maxillofacial neurogenic lesions submitted for diagnosis to our laboratory over a 31-year period (August 1984-March 2015).

    Materials And Methods: The available formalin-fixed embedded specimens, Hematoxylin and Eosin slides, demographic and clinical data were retrieved. Read More

    Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.
    Head Neck 2016 Aug 16;38(8):E2467-70. Epub 2016 Jun 16.
    Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
    Background: Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in the maxilla of an adolescent girl.

    Methods And Results: A 16-year-old female patient presented with palatal swelling. Read More

    Central granular cell odontogenic tumor: Report of an unusual case.
    Indian J Dent Res 2016 Mar-Apr;27(2):220-222
    Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India.
    Central granular cell odontogenic tumor (CGCOT) is an unusual benign odontogenic neoplasm characterized by the presence of granular cells associated with apparently inactive odontogenic epithelium. These tumors tend to occur in the posterior mandible and usually present as well-defined unilocular or multilocular radiolucent lesions. So far, only <40 cases of CGCOT have been described in the literature under various terminologies. Read More

    Lack of Utility of Cytokeratins in Differentiating Pseudocarcinomatous Hyperplasia of Granular Cell Tumors from Oral Squamous Cell Carcinoma.
    Asian Pac J Cancer Prev 2016 ;17(4):1785-7
    Oral Medicine and Orofacial Pain Center, University of Southern California, Los Angeles, California USA E-mail :
    Granular cell tumor (GCT) of the oral cavity is a benign lesion. Half of oral GCTs demonstrate pseudocarcinomatous hyperplasia (PCH) of the mucosa which can mimic invasive islands of oral squamous cell carcinoma (SCC). Such similarity can be confusing when diagnosing or evaluating the two conditions, potentially leading to misdiagnosis or misclassification. Read More

    Granular cell tumor in two oral anatomic sites.
    Eur Arch Otorhinolaryngol 2016 Oct 23;273(10):3439-41. Epub 2016 Mar 23.
    Postgraduate Program in Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte, Avenida Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59.056-000, Brazil.
    Granular cell tumor (GCT) is an uncommon benign soft tissue neoplasm, which usually presents as a solitary nodule, appearing especially in the tongue. There are few cases of multiple oral GCT in the English-language literature, with only three cases reported in the last 20 years. This report describes a case of two oral GCT in a young patient and provides a literature review from 1995 to 2015. Read More

    Immunohistochemical expression of Bcl-2 in oral epithelial dysplasia and oral squamous cell carcinoma.
    Indian J Cancer 2015 Oct-Dec;52(4):505-10
    Department of Oral Pathology, I.T.S. Centre for Dental Sciences and Research, Murad Nagar, Ghaziabad, Uttar Pradesh, India.
    Background: The B cell lymphoma-2 gene is a proto-oncogene whose protein product inhibits apoptosis. Its role is associated with keeping cells alive, but not by stimulating them to proliferation, as other proto-oncogenes do. Increased expression of protein product of Bcl-2 gene appears in the early phase of carcinogenesis leading to apoptosis impairment and in consequence to the progression of neoplastic changes. Read More

    Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review.
    Case Rep Pathol 2016 3;2016:8043183. Epub 2016 Jan 3.
    Department of Dermatology, Başkent University School of Medicine, 06490 Ankara, Turkey.
    Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Read More

    Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma.
    J Dermatol Case Rep 2015 Dec 31;9(4):89-97. Epub 2015 Dec 31.
    Department of Dermatology, Medical University of Warsaw, Poland; ; Departmet of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
    Squamous cell carcinoma is the second most common cutaneous malignancy after basal cell carcinoma. Although the gold standard of diagnosis for squamous cell carcinoma is biopsy followed by histopathology evaluation, optical non-invasive diagnostic tools have obtained increased attention. Dermoscopy has become one of the basic diagnostic methods in clinical practice. Read More

    Granular cells in ameloblastoma: An enigma in diagnosis.
    Indian J Dent 2015 Oct-Dec;6(4):211-4
    Department of Oral Pathology, SGT Dental College and Hospital, Gurgaon, New Delhi, India.
    Ameloblastoma is an epithelial odontogenic tumor exhibiting diverse microscopic pattern that occurs singly or in combination with other patterns. This article describes a case of granular cell ameloblastoma (GCA) involving mandible in a 55-year-old male. The possibility of granular component is there in other odontogenic and nonodontogenic lesions. Read More

    Cutaneous Granular Cell Tumor on the Arm in a Middle-Aged Man.
    J La State Med Soc 2015 Nov-Dec;167(6):252-3. Epub 2015 Dec 15.
    Dr. Crandall is affiliated with the Naval Medical Center, San Diego, CA.
    Granular Cell Tumors are uncommon, often benign neoplasms that occur primarily in the oral cavity. Granular Cell Tumors have also been reported in breast, gastrointestinal tissues, and less commonly in the dermis of the upper extremities. This is a case presentation of a 44-year-old Caucasian male with an asymptomatic Granular Cell Tumor on his right arm. Read More

    S-100 Negative Granular Cell Tumor of the Oral Cavity.
    Head Neck Pathol 2016 Sep 7;10(3):367-73. Epub 2015 Dec 7.
    Department of Diagnostic Sciences, College of Dental Medicine, #7377, Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL, 33328-2018, USA.
    Classic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. Read More

    Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature.
    Oncol Lett 2015 Aug 29;10(2):887-890. Epub 2015 May 29.
    Department of Pathology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430072, P.R. China.
    Small cell neuroendocrine carcinoma (SNEC) of the oral cavity is a rare and distinctive tumor with aggressive clinical behavior. Thus far, only a small number of cases have been reported and no definitive standard treatment strategy has been determined. The current study reports a case of oral SNEC arising in the lower gingiva in a 73-year-old male. Read More

    Granular Cell Tumors on Unusual Anatomic Locations.
    Yonsei Med J 2015 Nov;56(6):1731-4
    Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic locations, such as palm, arm, thigh, finger, and vulvar area. Read More

    Granular Cell Tumor: An Uncommon Benign Neoplasm.
    Indian J Dermatol 2015 May-Jun;60(3):322
    Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.
    Granular cell tumor is a distinctly rare neoplasm of neural sheath origin. It mainly presents as a solitary asymptomatic swelling in the oral cavity, skin, and rarely internal organs in the middle age. Histopathology is characteristic, showing polyhedral cells containing numerous fine eosinophilic granules with indistinct cell margins. Read More

    Interplay Between MMP-9 and TIMP-2 Regulates Ameloblastoma Behavior and Tooth Morphogenesis.
    Appl Immunohistochem Mol Morphol 2016 May-Jun;24(5):364-72
    Department of Oral and Maxillofacial Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the local invasiveness of ameloblastoma. This study aims to assess the role of MMP-9 and TIMP-2 in regulating tumor progression in ameloblastomas, taking tooth germs as control. Formalin-fixed, paraffin-embedded tissue sections of 4 tooth germs and 32 ameloblastomas were immunohistochemically examined using antibodies against MMP-9 and TIMP-2. Read More

    Congenital granular cell tumor - a rare entity.
    J Neonatal Surg 2015 Apr-Jun;4(2):17. Epub 2015 Apr 1.
    Dept of General Surgery, Peoples College of Medical Sciences, Bhanpur bypass road, Bhopal.
    Congenital granular cell tumor is a rare benign neoplastic growth affecting the gingival mucosa of neonates. Prenatal ultrasound diagnosis has recently come to focus and in spite of several reports on immune-histochemical and other advanced marker studies, the cause and origin of the lesion remains debatable till date. Review of literature on prenatal diagnosis and histopathology along with immunohistochemistry is discussed. Read More

    Aggressive granular cell ameloblastoma: Report of a rare case.
    J Pharm Bioallied Sci 2015 Apr;7(Suppl 1):S276-8
    Department of Oral Pathology and Microbiology, Kalinga Institute of Dental Sciences, Bhubaneshwar, Odisha, India.
    Granular cell ameloblastoma is a slow growing odontogenic ectodermal tumor. The tumor shows typical ameloblastoma with the cells showing eosinophilic granularity. This variant of ameloblastoma is aggressive with high recurrence rates. Read More

    Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology.
    PLoS One 2015 11;10(5):e0125598. Epub 2015 May 11.
    Biomedical Engineering Department, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.
    Proflavine hemisulfate, an acridine-derived fluorescent dye, can be used as a rapid stain for cytologic examination of biological specimens. Proflavine fluorescently stains cell nuclei and cytoplasmic structures, owing to its small amphipathic structure and ability to intercalate DNA. In this manuscript, we demonstrated the use of proflavine as a rapid cytologic dye on a number of specimens, including normal exfoliated oral squamous cells, cultured human oral squamous carcinoma cells, and leukocytes derived from whole blood specimens using a custom-built, portable, LED-illuminated fluorescence microscope. Read More

    Effect of Phenylephrine Pretreatment on the Expressions of Aquaporin 5 and c-Jun N-Terminal Kinase in Irradiated Submandibular Gland.
    Radiat Res 2015 Jun 7;183(6):693-700. Epub 2015 May 7.
    a  Department of Oral Medicine and Medical Research Center, Medical College, Dalian University, Dalian 116622, P.R. China;
    Radiotherapy for malignant tumors of the head and neck commonly leads to radiation-induced sialadenitis as a result of radiation-induced salivary gland dysfunction. We demonstrated previously that phenylephrine could protect the irradiated submandibular gland against apoptosis, although the mechanism is unclear. In this study, we investigated the influence of phenylephrine pretreatment on the expressions of aquaporin 5 (AQP5) and c-Jun N-terminal kinase (JNK) that were presumed to have a role in radiation-induced salivary gland dysfunction. Read More

    Multiple granular cell tumors with metachronous occurrence in tongue and vulva. Clinicopathological and immunohistochemical study.
    J Oral Maxillofac Pathol 2014 Sep-Dec;18(3):437-41
    Department of Pathology, University of Valencia, La Fe University Hospital, Valencia, Spain.
    Granular cell tumor (GCT) usually occurs as a single tumor, although sometimes multiple lesions can occur. In present report we analyze the clinicopathological and immunohistochemical features of a multiple GCT involving the tongue of a 14-year-old girl, with no other abnormalities, with a metachronous occurrence of a second GCT in vulva, after a period of 10 years. Both tumors revealed S-100, vimentin and CD57 positivity. Read More

    Primary Merkel cell carcinoma of the oral mucosa in a young adult male: report of a rare case.
    Indian J Pathol Microbiol 2015 Apr-Jun;58(2):214-6
    Medical College, Kolkata, West Bengal, India.
    Merkel cell carcinoma (MCC) is a highly aggressive neoplasm of skin with neuroendocrine differentiation. Primary MCC of the oral mucosa is exceedingly rare and even more unresponsive to therapy. A 15-year-old male presents with gradually increasing painless swelling in right side of the floor of mouth for 6 weeks. Read More

    Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27.
    J Invest Dermatol 2015 Jul 11;135(7):1801-9. Epub 2015 Mar 11.
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.
    The fused-type S100 protein profilaggrin and its proteolytic products including filaggrin are important in the formation of a normal epidermal barrier; however, the specific function of the S100 calcium-binding domain in profilaggrin biology is poorly understood. To explore its molecular function, we determined a 2.2 Å-resolution crystal structure of the N-terminal fused-type S100 domain of human profilaggrin with bound calcium ions. Read More

    Congenital epulides: a rare case report.
    Indian J Dent Res 2014 Nov-Dec;25(6):806-8
    Department of Dental and Oral Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
    Congenital epulis (CE) or "Granular cell epulis" also previously termed as "Neumann's tumor" is a benign growth arising from the mucosa of the gingiva, typically seen as a mass protruding from the infant's mouth, often interfering with respiration and feeding. These tumors generally present as a single mass arising from the upper alveolus. We report a rare case of two congenital epulides arising from the maxillary and mandibular alveolus in a day old female infant, which was surgically excised, allowing for early initiation of breast feeding. Read More

    Central Granular Cell Odontogenic Tumor: Report of a Case with CBCT Features.
    J Dent (Tehran) 2014 May 31;11(3):365-70. Epub 2014 May 31.
    Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
    Central granular cell odontogenic tumor) CGCOT) of the jaw is an exceedingly rare benign odontogenic neoplasm with 35 reported cases in the literature. Among these, very few studies have focused on the cone-beam CT features of CGCOT. Here, we report a case of an asymptomatic CGCOT in a 16-year-old girl and focus on the cone-beam CT features. Read More

    Granular cell tumor in the breast mimicking breast carcinoma.
    JBR-BTR 2014 Sep-Oct;97(5):289-90
    Department of Radiology, Algemeen Stedelijk Ziekenhuis Aalst, Belgium.
    Granular cell tumor is also known as a granular cell myoblastoma, Abrikossoff's tumor, granular cell nerve sheath tumor or granular cell scwhannoma. It is a rare soft-tissue mass that can develop in any soft tissue. Most commonly it appears in the tongue (40%), the oral cavity or in the subcutaneous tissue. Read More

    From newborn to toddler: report of two cases of congenital granular cell tumor.
    J Oral Maxillofac Surg 2015 Feb 18;73(2):291-4. Epub 2014 Sep 18.
    Chair, Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea; Visiting Professor, Department of Pediatric Dentistry, School of Dentistry, University of Washington, Seattle, WA. Electronic address:
    A congenital granular cell tumor (CGCT) is an uncommon benign soft tissue lesion that usually arises from the alveolar ridge in newborns. It can severely interfere with the respiratory and feeding systems, if left untreated. We present the cases of 2 newborn infants with protruded intraoral tumors that severely compromised breastfeeding. Read More

    Congenital epulis in a newborn: a case report, immunoprofiling and review of literature.
    Ethiop J Health Sci 2014 Oct;24(4):359-62
    Department of Oral Medicine and radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.
    Background: Congenital epulis is a rare lesion of the newborn, presenting as mass in the oral cavity which can interfere with respiration and feeding. It should be distinguished from other lesions which can occur in newborns, both clinically and histopathologically.

    Case Details: Here, we report a case of congenital epulis in a newborn female on the right alveolar ridge, along with an extensive review of literature and discuss the immunoprofiling. Read More

    Multiple congenital granular cell epulis in a female newborn: a case report.
    J Med Case Rep 2014 Dec 8;8:413. Epub 2014 Dec 8.
    Department of Oral and Cranio-maxillofacial Science, Ninth People's Hospital, Shanghai Jiao Tong University, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
    Introduction: Congenital granular cell epulis is an uncommon tumor which is apparent at birth.

    Case Presentation: Here we report an unusual case of congenital granular cell epulis present in the mouth of a 4-day-old Asian Chinese female newborn. She had six round, soft, multiple, pedunculated swelling masses, of which two were on her upper anterior ridge and four on her lower anterior ridge. Read More

    Granular cell ameloblastoma: case report of a particular ameloblastoma histologically resembling oncocytoma.
    Pathol Int 2015 Jan 25;65(1):43-7. Epub 2014 Nov 25.
    Department of Clinical Oral Oncology, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Granular cell ameloblastoma is classified as a histological subtype of solid/multicystic ameloblastoma. Usual granular cell ameloblastoma is histologically characterized by granular changes of stellate-like cells located in the inner portion of the epithelial follicles. Here we report a case of another type of granular cell ameloblastoma, showing predominant anastomosing double-stranded trabeculae of granular cells. Read More

    Congenital giant epulis obstructing oral cavity: newborn emergency.
    Pan Afr Med J 2014 13;17:195. Epub 2014 Mar 13.
    Pediatric Surgery Department Sylvanus Olympio Teaching Hospital, Lomé, Togo.
    The congenital epulis is a benign congenital granular cell tumor arising most often of the alveolar ridge of the jawbone. When giant, it is source of digestive discomfort disabling feeding. We report the case of a newborn female, vaginal delivery, presented with a giant intraoral tumor. Read More

    Massive granular cell ameloblastoma with dural extension and atypical morphology.
    Contemp Clin Dent 2014 Oct;5(4):535-8
    Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneshwar, Odisha, India.
    Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ectoderm that occasionally reach a gigantic size. Giant ameloblastomas are a rarity these days with the advent of panoramic radiography in routine dental practice. Furthermore, the granular cell variant is an uncommon histological subtype of ameloblastoma where the central stellate reticulum like cells in tumor follicles is replaced by granular cells. Read More

    Granular cell type of a unicystic ameloblastoma: An unusual case and review of the literature.
    J Oral Maxillofac Pathol 2014 May;18(2):331
    Department of Oral and Maxillofacial Pathology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Ameloblastomas are locally invasive tumors of odontogenic epithelial origin. They have been categorized broadly into three biologic variants: solid, cystic (unicystic) and peripheral, of which only 13% of all cases are unicystic. Although rare in unicystic or cystic ameloblastoma, granular cell change in ameloblastoma is a recognized phenomenon. Read More

    Congenital Granular Cell Tumor of the Arm: A Rare Presentation.
    Am J Dermatopathol 2015 Sep;37(9):712-4
    Departments of *Dermatology, and †Pathology, Şişli Etfal Training and Research Hospital, Istanbul, Turkey.
    Congenital granular cell tumors are uncommon benign tumors of newborns that mainly affect oral mucosa, especially the maxillary alveolar ridge. They are predominantly seen in female newborns, and cutaneous involvement is extremely rare. In this report, we present a case of congenital granular cell tumor on the arm of one of the male monozygotic twins and discuss the differential diagnosis of granular cell phenotype. Read More

    Analysis of prevalence and clinical features of multicystic ameloblastoma and its histological subtypes in South Indian sample population: A retrospective study over 13 years.
    J Pharm Bioallied Sci 2014 Jul;6(Suppl 1):S131-4
    Department of Oral and Maxillofacial Pathology and Microbiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India.
    Objective: The study was designed to analyze the frequency and clinical features of multicystic ameloblastoma and its histological variants in South Indian sample population, as there is minute information available in the English literature.

    Methodology: The study source was the biopsy specimens retrieved from the archives of the Department of Oral and Maxillofacial Pathology, College of Dental Sciences, Davangere, Karnataka, India, during the past 13 years, from 2001 to 2013. Clinical data for the study were obtained from the case records of patients and the analyzed clinical variables were age, gender and anatomical location. Read More

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