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J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S101-S105. Epub 2020 Feb 28.

Department of Experimental and Clinical Medicine, Maxillo-Facial Unit, Magna Graecia University, Catanzaro, Italy.

Abrikossoff 's tumor, also called granular cell tumor (GCT), is a rare benign neoplasm of the soft tissues. In almost 70% of the cases, it occurs in the head-and-neck region (especially in the tongue), even though it may present in every other part of the body. This neoplasm has a benign behavior usually, but there have been described a malignant transformation in 2%-3% of the cases. Read More

J Oral Maxillofac Pathol 2019 Sep-Dec;23(3):432-437

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune, Maharashtra, India.

Odontogenic keratocyst (OKC) originates from the dental lamina and is more commonly seen in the posterior mandible than in the maxilla. OKC is the most aggressive cyst of the oral cavity and is known for its rapid growth and its tendency to invade bone of the adjacent tissues. The recurrence rate of OKC is very high due to various reasons debated upon. Read More

J Dent (Shiraz) 2019 Dec;20(4):304-307

Oral and Maxillofacial Surgen, Tehran, Iran.

Ameloblastomas demonstrate various clinical and microscopic patterns. They typically have been described as possessing three biologic variants including solid, cystic (unicystic) and peripheral, of which about 13% to 21% of all cases are unicystic. Granular cell subtype is a rare variant especially when both the inner and peripheral layers of tumoral islands composed exclusively of eosinophilic granular cells. Read More

Indian J Dermatol Venereol Leprol 2020 Jan-Feb;86(1):57-59

Department of Pathology, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

J Clin Exp Dent 2019 Aug 1;11(8):e721-e731. Epub 2019 Aug 1.

MD, DDS, PhD, Professor, Head of Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Greece.

Background: Oral neural tumors (ONTs) are rare lesions and represent reactive or neoplastic proliferations of nerve sheath cells. The purpose of the present study is to report the clinical, demographic and histopathologic features of 157 ONTs diagnosed in a single Oral Pathology Department and review the pertinent literature.

Material And Methods: 157 cases of ONTs diagnosed during a 44-year period were retrospectively collected and the diagnosis was reconfirmed by studying representative haematoxylin and eosin stained tissue sections. Read More

J Dent (Shiraz) 2019 Sep;20(3):220-223

Postgraduate Student, Dept. of Endodontic, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The granular cell odontogenic tumor is an extremely rare odontogenic neoplasm which about 38 cases has been reported with sufficient documentation in the literature. It has a prominent predilection to occur in the posterior of mandible of middle-aged women. Here, we report a case of mandibular granular cell odontogenic tumor in a 57-year-old female with chief complaint of swelling and tooth mobility. Read More

Radiographics 2019 Jul-Aug;39(4):1143-1160

From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA (M.C.C., Y.L., D.J.S., O.A.G., C.M.G., J.L.C.) and the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD (B.P.S.).

Although congenital oral masses are rare, they are readily detectable during fetal US screening. Most congenital oral masses are benign, but some may cause mechanical airway obstruction, resulting in poor outcomes at delivery. The radiologist's ability to describe these abnormalities and their physiologic sequelae accurately can have a substantial effect on perinatal treatment. Read More

Clin Pathol 2019 Jan-Dec;12:2632010X19831257. Epub 2019 Feb 21.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Japan.

Introduction: Congenital granular cell epulis is a rare and benign lesion in newborn. There are some papers of the entity; however, there are very few reports focusing on its macroscopic view.

Case Presentation: A 0-day-old boy was noted to have a mass consisting of multiple nodules on maxillary gingiva, and it was excised. Read More

Head Neck Pathol 2020 Jun 10;14(2):392-398. Epub 2019 Jun 10.

Department of Oral Pathology, School of Dentistry, Federal University of Pará, Belem, Brazil.

The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front. Thirty-seven cases of previously diagnosed formalin-fixed paraffin-embedded (FFPE) human ameloblastoma samples were selected for this study. The samples were grouped according to the predominant histologic pattern and comprised twelve plexiform, eighteen follicular, and seven unicystic ameloblastomas. Read More

Cureus 2019 Feb 14;11(2):e4074. Epub 2019 Feb 14.

Pathology, Orlando Veterans Affairs Medical Center, Orlando, USA.

Granular cell tumors (GCT) are usually benign, soft tissue tumors that are mostly found in the oral cavity, skin, and subcutaneous tissue. GCTs in the gastrointestinal (GI) tract are mainly located in the esophagus. A 63-year-old male was referred to the gastroenterology clinic for a major complaint of six months of painless rectal bleeding. Read More

SAGE Open Med Case Rep 2019 19;7:2050313X19838184. Epub 2019 Mar 19.

Pôle d'Odontologie, Hôpital Maison Blanche, Centre Hospitalier Universitaire Reims, Reims, France.

Schwannomas are benign peripheral nerve sheath tumors originating from the Schwann cells. Most schwannomas in the head and neck region are solitary; however, multiple schwannomas affecting one or more nerves suggest a possible association with neurofibromatosis type 2 and schwannomatosis. Plexiform schwannoma is a rare variant of conventional schwannoma that is characterized by intraneural multinodular growth. Read More

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

General Surgery Department, Hospital Sao Francisco Xavier, Lisboa, Portugal.

Granular cell tumours are rare neoplasms that may occur anywhere in the body. The most common locations are the oral cavity, skin and subcutaneous tissue, with only 8% of these tumours occurring at a gastrointestinal site. In the specific case of gastric granular cell tumours, only a few cases have been published until today. Read More

Rinsho Ketsueki 2019;60(1):39-45

Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.

T-cell large granular lymphocyte (T-LGL) leukemia is a chronic T-cell monoclonal disease that is occasionally associated with pure red cell aplasia (PRCA). A 71-year-old previously healthy man complained of physical fatigue and exhibited anemia (hemoglobin, 10.5 g/dl) with lymphocytosis (76%) showing LGL. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):79-81

Department of Pathology, Hospital Militar Central, Universidad Militar Nueva Granada, Bogotá, Colombia.

We report the case of a 47-year-old male patient with S100 negative granular cell tumor of the oral cavity, focusing on dermoscopic features as well as surgical approach, not previously reported in the literature. The study contributes to the literature on dermoscopy and surgical treatment for this tumor and provides a practical approach to differentiating non-neural granular cell tumors and granular cell tumors. Read More

Head Neck Pathol 2019 Mar 31;13(1):33-46. Epub 2019 Jan 31.

Virginia Commonwealth University School of Dentistry, Richmond, VA, USA.

When faced with an uncertain clinical pathosis in the oral cavity, identifying the color of the mucosal lesion helps to narrow down a differential diagnosis. Although less common than red and white lesions, yellow lesions encompass a small group of distinct mucosal pathologic entities. Adipose tissue, lymphoid tissue, and sebaceous glands are naturally occurring yellow constituents of the oral cavity and become apparent with associated developmental or neoplastic lesions. Read More

Indian J Dent Res 2018 Nov-Dec;29(6):830-835

Department of Conservative and Endodontics. M.A. Rangoonwala College of Dental Sciences and Research Center, Pune, Maharashtra, India.

Ameloblastoma is a benign locally aggressive type of odontogenic tumor derived exclusively from the epithelium. Histologically, ameloblastoma is classified into many variants, of which granular cell ameloblastoma (GCA) is a rare type, characterized by nest of large eosinophilic granular cells. This article describes a case of GCA in a 50-year-old female patient with clinical, radiological, and histological features along with a systematic review of the literature. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Pediatrics, Monmouth Medical Center, Long Branch, New Jersey, USA.

Congenital granular cell lesion (CGCL) is an uncommon, benign soft tissue lesion that usually arises from the alveolar mucosa of neonates. The present report describes a case of CGCL originating from the tongue of a newborn female infant. The lesion was negative for S-100 differentiating it from congenital granular cell tumour. Read More

J Clin Med 2018 Dec 10;7(12). Epub 2018 Dec 10.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.

Zinc finger AN1-type containing 4 (ZFAND4) has emerged as a promising prognostic marker and predictor of metastasis for patients with oral squamous cell carcinoma (OSCC). However, further validation is fundamental before clinical implementation. Hence, this study evaluated the expression pattern of ZFAND4 protein expression by immunohistochemistry using an independent cohort of 125 patients with OSCC, and correlations with the clinicopathologic parameters and disease outcome. Read More

Autops Case Rep 2018 Apr-Jun;8(2):e2018025. Epub 2018 Jun 8.

a Centro Hospitalar de São João, Medical Oncology Department. Porto, Portugal.

Large-cell neuroendocrine tumors (NETs) are poorly differentiated malignancies of rare incidence and aggressive nature. NETs mostly arise in the lung followed by the gastrointestinal tract, although they are potentially ubiquitous throughout the body. Primary unknown NET has a worse prognosis and shorter survival comparing with other NETs, with limited available data in the literature concerning this subgroup. Read More

J Am Acad Dermatol 2019 Jul 14;81(1):43-56. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts; US Department of Veteran Affairs, Boston Health Care System, Boston, Massachusetts. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatologic conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features, to be able to recognize benign versus malignant disease, and to recognize when obtaining a biopsy specimen is warranted. The first article in this continuing medical education series reviews oral anatomy, the clinical attributes of several benign lesions of the oral cavity, and appropriate management and therapeutic modalities. Read More

Indian J Dent Res 2018 Sep-Oct;29(5):687-689

Consultant, Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India.

Granular cell tumor (GCT) is a rare soft-tissue neoplasm, first described in 1926. GCT often manifests as a single, painless nodule that shows a slow enlargement in the cutaneous, subcutaneous, or submucosal tissues. It is commonly reported in adults in the third to sixth decade of life. Read More

J Indian Soc Pedod Prev Dent 2018 Jul-Sep;36(3):319-323

Oral Health Sciences Centre, Unit of Pedodontics and Preventive Dentistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital granular cell tumor of the newborn is a benign, relatively innocuous hamartomatous lesion arising from the alveolar ridge. Large lesions often warrant prompt surgical removal owing to the associated difficulty in breastfeeding and respiration of the infant. However, for medium-sized lesions, another approach could be observed for spontaneous regression. Read More

Clin Imaging 2018 Nov - Dec;52:334-336. Epub 2018 Sep 9.

University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, United States of America. Electronic address:

Granular cell tumor is an exceedingly rare pediatric breast mass, derived from Schwann cells which are most commonly observed in the oral cavity, skin, and subcutaneous tissue. When they occur in the breast, they can mimic intrinsic breast masses. Most cases are benign, but malignant cases have been reported. Read More

Clin Exp Dermatol 2019 Apr 22;44(3):316-318. Epub 2018 Aug 22.

Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Biomed Eng Comput Biol 2018 2;9:1179597218790250. Epub 2018 Aug 2.

Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA.

Background: Granular cell tumor (GCT) is a relatively uncommon tumor that may affect the skin. The tumor can develop anywhere on the body, although it is predominately seen in oral cavities and in the head and neck regions. Here, we present the results of optical coherence tomography (OCT) imaging of a large GCT located on the abdomen of a patient. Read More

Am J Surg Pathol 2018 09;42(9):1133-1142

Departments of Pathology.

Non-neural granular cell tumor (NNGCT; also known as primitive polypoid granular cell tumor) is a rare neoplasm composed of large ovoid cells with abundant granular cytoplasm, variable nuclear pleomorphism, and the potential for regional lymph node spread. In contrast to conventional granular cell tumor (GCT), NNGCT lacks S100 expression and can exhibit greater nuclear atypia and mitotic activity. Therefore, we investigated clinicopathologic features of 12 NNGCT, and also used next-generation sequencing to identify potential driver events in a subset of NNGCT and 6 GCT. Read More

Bull Tokyo Dent Coll 2018 ;59(2):127-132

Department of Clinical Pathophysiology, Tokyo Dental College.

Congenital epulis is an unusual benign oral mucosal lesion in newborns with no tendency to recur after excision. The histogenesis of the lesion is unknown, but it is believed to be of mesenchymal origin. We describe a case of congenital epulis (20×10 mm) in the mandibular gingiva of a newborn. Read More

Head Neck Pathol 2019 Jun 21;13(2):208-214. Epub 2018 Jun 21.

Oral and Maxillofacial Diagnostic Sciences College of Dentistry, University of Florida, 1395 Center Dr, Gainesville, FL, 32610, USA.

Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spanning from 1994 to 2015 was performed. Read More

Dent Res J (Isfahan) 2018 May-Jun;15(3):224-227

Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Ameloblastoma is a locally invasive tumor derived from odontogenic epithelium. An uncommon variant of ameloblastoma is granular cell type, which cannot distinguish from other ameloblastoma subtypes by clinical and radiographic findings alone. Only review of it's microscopic features allows distinction from other subtypes. Read More

Case Rep Dent 2018 22;2018:1615086. Epub 2018 Apr 22.

Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Background: Verruciform xanthoma is an uncommon benign tumor, which exhibits a wide range of clinical patterns. The occurrence of the lesion in patients with immune-mediated mucocutaneous diseases may suggest a role of localized epithelial cell damage and chronic inflammation in its pathogenesis.

Case Report: A case of verruciform xanthoma on the tongue of a 56-year-old female with oral lichen planus is reported. Read More

J Clin Exp Dent 2018 May 1;10(5):e495-e498. Epub 2018 May 1.

Department of Oral Medicine and Pathology, Dental School, University of Athens, Greece.

Mucoceles represent one of the most common lesions of the oral cavity, developing as a result of saliva accumulation. The most frequent affected area is the lower lip, followed by floor of mouth, ventral tongue and buccal mucosa. Despite numerous reports of mucoceles originating on the ventral surface of the tongue, only scarce cases of such a lesion identified on the dorsal tongue surface have been described. Read More

Lasers Surg Med 2018 07 19;50(5):513-522. Epub 2018 May 19.

Department of Otorhinolaryngology and Head and Neck Surgery, Center for Optical Diagnostics and Therapy, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: The aim of this study was to investigate the effects of targeted photoimmunotherapy (PIT) in vitro on cell lines with various expression levels of epidermal growth factor receptor (EGFR) using an anti-EGFR targeted conjugate composed of Cetuximab and IR700DX, phthalocyanine dye.

Materials And Methods: Relative EGFR density and cell binding assay was conducted in three human head & neck cancer cell lines (scc-U2, scc-U8, and OSC19) and one reference cell line A431. After incubation with the conjugate for 1 or 24 hours, cellular uptake and localization were investigated by confocal laser scanning microscopy and quantified by image analysis. Read More

Ann Ital Chir 2018 Apr 23;7. Epub 2018 Apr 23.

Aim: To report on a case of granular cell tumour occurring in the tongue surgically removed by surgical radiofrequency, with histological examination.

Material Of Study: Discussion on the clinico-pathological characteristics of the granular cell tumour and the surgical treatment by surgical radiofrequency: the differential diagnosis is also discussed.

Results: Histological examination is mandatory for the final diagnosis. Read More

Cureus 2018 Jan 2;10(1):e2015. Epub 2018 Jan 2.

Division of Gastroenterology, NYU Langone Hospital, 150 55th St Brooklyn, Ny, 11220.

Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. Read More

J Clin Exp Dent 2017 Dec 1;9(12):e1459-e1465. Epub 2017 Dec 1.

DDS, MSc, PhD, Professor, Area of Pathology, School of Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Background: Oral peripheral nerve sheath tumors (OPNSTs) are reactive or neoplastic diseases that develop from proliferation of the nerve itself or their limiting sheaths. Here we describe the clinicopathologic data of OPNSTs observed in a sample of the Brazilian population and evaluate the expression of molecules associated with neural biology to determine their usefulness in the diagnosis.

Material And Methods: Descriptive study of cases diagnosed as OPNSTs, from the Pathology Laboratory at the School of Dentistry/ Federal University of Uberlandia, followed by an immunohistochemical study of S-100, CD57, neurofilament protein (NFP) and epithelial membrane antigen (EMA). Read More

J Pediatr 2018 05 11;196:322. Epub 2018 Jan 11.

Department of Pediatric Otorhinolaryngology Spedali Civili Brescia, Italy.

Head Face Med 2018 Jan 3;14(1). Epub 2018 Jan 3.

Department of Oral and Maxillofacial Surgery, Plastic Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Background: Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue. Read More

Gastroenterology Res 2017 Dec 3;10(6):372-375. Epub 2018 Jan 3.

Department of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.

Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. Read More

Case Rep Pulmonol 2017 15;2017:8513702. Epub 2017 Oct 15.

Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Granular cell tumor (GCT) is a neoplasm of Schwann cell origin. Its presence in the aerodigestive tract is uncommon and becomes a diagnostic challenge on initial presentation. Our case is of a 59-year-old woman who presented to the emergency department with a history of productive cough and dyspnea associated with fever and chest pain. Read More

Cell Death Discov 2017 14;3:17047. Epub 2017 Aug 14.

Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan.

Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined. The proportion of viable cells after PF-543 treatment decreased in a time- and dose-dependent manner, and cell death occurred in SphK1-expressing SCC cells. Read More

J Clin Pathol 2018 01 2;71(1):93-94. Epub 2017 Nov 2.

Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Rare Tumors 2017 Jul 29;9(2):6420. Epub 2017 Aug 29.

Departments of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, India.

Granular cell tumor (GCT) also known as Abrikossoff's tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. It is most frequently seen in the oral cavity, skin, and subcutaneous tissue. Gastrointestinal tract involvement is uncommon, in which esophagus is the most commonly affected site. Read More

J Complement Integr Med 2017 Apr 15;14(3). Epub 2017 Apr 15.

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Background We reported recently that extracts of seeds of Garcinia kola, a plant with established hypoglycemic properties, prevented the loss of inflammation-sensible neuronal populations like Purkinje cells in a rat model of type 1 diabetes mellitus (T1DM). Here, we assessed G. kola extract ability to prevent the early cognitive and motor dysfunctions observed in this model. Read More

Neurosci Lett 2017 Sep 16;658:1-5. Epub 2017 Aug 16.

Department of Radiation Oncology, Stony Brook University Hospital, Stony Brook, NY, United States.

Purpose: This study evaluates FTY720/Fingolimod, modulator of sphingosine-1-phosphate (S1P) receptor, as a potential mitigator of radiation-induced neurocognitive dysfunction.

Methods And Materials: To study radiation-induced neurocognitive deficits, 6 week-old C57/Bl/6J mice received 0 or 7Gy cranial irradiation and were treated with FTY720 or vehicle for seven weeks. Fear conditioning and Morris water maze were then employed to test learning and memory. Read More

J Surg Case Rep 2017 Jun 6;2017(6):rjw186. Epub 2017 Jun 6.

Department of Surgery, Boca Raton Regional Hospital, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.

Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. Read More

Swiss Dent J 2017;127(4):312-313

Klinik für Oralchirurgie und Stomatologie, Zahnmedizinische Kliniken der Universität Bern, Bern, Switzerland.

J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):183

Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.

A 42-year-female patient presented with a swelling on the left side of the face for the past 10 years. The radiograph shows multilocular radiolucency with evidence of root resorption. Histopathology reveals fibrous connective tissue exhibiting numerous odontogenic epithelial islands with peripheral tall columnar cells showing a reversal of polarity. Read More

J Dermatol Sci 2017 Aug 30;87(2):116-122. Epub 2017 Mar 30.

Anacor Pharmaceuticals, Inc., 1020 E Meadow Circle, Palo Alto 94303, CA, USA.

Background: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis.

Objective: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole.

Methods: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks. Read More

J Dent (Shiraz) 2017 Mar;18(1):70-72

Dept. of Pathology, Gulhane Education and Research Hospital, Ankara, Turkey.

The congenital gingival granular cell tumor (CGCT), also as known as congenital epulis, is an unusual benign oral mucosal lesion in newborns. A two-day-old female patient was admitted to the Department of Pediatric Dentistry at Gulhane Medical Academy, Ankara, Turkey with her family, and an intraoral examination showed a CGCT located in the buccal region of the maxillary right first primary molar. In this report, we present a case of CGCT in a newborn. Read More

BMC Res Notes 2017 Jan 3;10(1):14. Epub 2017 Jan 3.

Department of Oral Medicine (Oral Pathology), Dental School, Faculdade de Odontologia, Universidade Federal de Goiás, Praça Universitária, S/N, Setor Universitário, Goiânia-Goiás, CEP 74605-220, Brazil.

Background: Granular cell tumor is a rare benign tumor that can present a pseudoepitheliomatous hyperplasia of the covering epithelium. This lesion is not encapsulated and can be characterized by a pseudo invasive growth pattern, represented by the tumoral cells that infiltrate between adjacent connective tissue elements. Diagnostic difficulties may arise because histopathological features of the pronounced pseudoepitheliomatous hyperplasia can be confused with a well-differentiated oral squamous cell carcinoma. Read More