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    1 OF 11
    Colonic Granular Cell Tumor: An Endoscopic and Histopathologic Review with Case Illustration.
    Cureus 2018 Jan 2;10(1):e2015. Epub 2018 Jan 2.
    Division of Gastroenterology, NYU Langone Hospital, 150 55th St Brooklyn, Ny, 11220.
    Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. Read More
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    Oral peripheral nerve sheath tumors: A clinicopathological and immunohistochemical study of 32 cases in a Brazilian population.
    J Clin Exp Dent 2017 Dec 1;9(12):e1459-e1465. Epub 2017 Dec 1.
    DDS, MSc, PhD, Professor, Area of Pathology, School of Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
    Background: Oral peripheral nerve sheath tumors (OPNSTs) are reactive or neoplastic diseases that develop from proliferation of the nerve itself or their limiting sheaths. Here we describe the clinicopathologic data of OPNSTs observed in a sample of the Brazilian population and evaluate the expression of molecules associated with neural biology to determine their usefulness in the diagnosis.

    Material And Methods: Descriptive study of cases diagnosed as OPNSTs, from the Pathology Laboratory at the School of Dentistry/ Federal University of Uberlandia, followed by an immunohistochemical study of S-100, CD57, neurofilament protein (NFP) and epithelial membrane antigen (EMA). Read More
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    Granular cell tumors of the tongue: fibroma or schwannoma.
    Head Face Med 2018 Jan 3;14(1). Epub 2018 Jan 3.
    Department of Oral and Maxillofacial Surgery, Plastic Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
    Background: Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue. Read More
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    Esophageal Granular Cell Tumor: A Case and Review of the Literature.
    Gastroenterology Res 2017 Dec 3;10(6):372-375. Epub 2018 Jan 3.
    Department of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.
    Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. Read More
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    Multifocal Pulmonary Granular Cell Tumor Presenting with Postobstructive Pneumonia.
    Case Rep Pulmonol 2017 15;2017:8513702. Epub 2017 Oct 15.
    Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
    Granular cell tumor (GCT) is a neoplasm of Schwann cell origin. Its presence in the aerodigestive tract is uncommon and becomes a diagnostic challenge on initial presentation. Our case is of a 59-year-old woman who presented to the emergency department with a history of productive cough and dyspnea associated with fever and chest pain. Read More
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    Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
    Cell Death Discov 2017 14;3:17047. Epub 2017 Aug 14.
    Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan.
    Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined. The proportion of viable cells after PF-543 treatment decreased in a time- and dose-dependent manner, and cell death occurred in SphK1-expressing SCC cells. Read More
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    Sporadic granular cell tumours lack recurrent mutations in and other cancer-related genes.
    J Clin Pathol 2018 Jan 2;71(1):93-94. Epub 2017 Nov 2.
    Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
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    Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge.
    Rare Tumors 2017 Jul 29;9(2):6420. Epub 2017 Aug 29.
    Departments of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, India.
    Granular cell tumor (GCT) also known as Abrikossoff's tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. It is most frequently seen in the oral cavity, skin, and subcutaneous tissue. Gastrointestinal tract involvement is uncommon, in which esophagus is the most commonly affected site. Read More
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    Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation.
    J Complement Integr Med 2017 Apr 15;14(3). Epub 2017 Apr 15.
    .
    Background We reported recently that extracts of seeds of Garcinia kola, a plant with established hypoglycemic properties, prevented the loss of inflammation-sensible neuronal populations like Purkinje cells in a rat model of type 1 diabetes mellitus (T1DM). Here, we assessed G. kola extract ability to prevent the early cognitive and motor dysfunctions observed in this model. Read More
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    FTY720/fingolimod, an oral S1PR modulator, mitigates radiation induced cognitive deficits.
    Neurosci Lett 2017 Sep 16;658:1-5. Epub 2017 Aug 16.
    Department of Radiation Oncology, Stony Brook University Hospital, Stony Brook, NY, United States.
    Purpose: This study evaluates FTY720/Fingolimod, modulator of sphingosine-1-phosphate (S1P) receptor, as a potential mitigator of radiation-induced neurocognitive dysfunction.

    Methods And Materials: To study radiation-induced neurocognitive deficits, 6 week-old C57/Bl/6J mice received 0 or 7Gy cranial irradiation and were treated with FTY720 or vehicle for seven weeks. Fear conditioning and Morris water maze were then employed to test learning and memory. Read More
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    A rare case of perianal granular cell tumor: case report and literature review.
    J Surg Case Rep 2017 Jun 6;2017(6):rjw186. Epub 2017 Jun 6.
    Department of Surgery, Boca Raton Regional Hospital, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
    Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. Read More
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    Granular cell ameloblastoma.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):183
    Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, Kanchipuram, Tamil Nadu, India.
    A 42-year-female patient presented with a swelling on the left side of the face for the past 10 years. The radiograph shows multilocular radiolucency with evidence of root resorption. Histopathology reveals fibrous connective tissue exhibiting numerous odontogenic epithelial islands with peripheral tall columnar cells showing a reversal of polarity. Read More
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    2-Year animal carcinogenicity results for crisaborole, a novel phosphodiesterase 4 inhibitor for atopic dermatitis.
    J Dermatol Sci 2017 Aug 30;87(2):116-122. Epub 2017 Mar 30.
    Anacor Pharmaceuticals, Inc., 1020 E Meadow Circle, Palo Alto 94303, CA, USA.
    Background: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis.

    Objective: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole.

    Methods: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks. Read More
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    Congenital Gingival Granular Cell Tumor: A Case Report.
    J Dent (Shiraz) 2017 Mar;18(1):70-72
    Dept. of Pathology, Gulhane Education and Research Hospital, Ankara, Turkey.
    The congenital gingival granular cell tumor (CGCT), also as known as congenital epulis, is an unusual benign oral mucosal lesion in newborns. A two-day-old female patient was admitted to the Department of Pediatric Dentistry at Gulhane Medical Academy, Ankara, Turkey with her family, and an intraoral examination showed a CGCT located in the buccal region of the maxillary right first primary molar. In this report, we present a case of CGCT in a newborn. Read More
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    Granular cell tumor mimicking a squamous cell carcinoma of the tongue: a case report.
    BMC Res Notes 2017 Jan 3;10(1):14. Epub 2017 Jan 3.
    Department of Oral Medicine (Oral Pathology), Dental School, Faculdade de Odontologia, Universidade Federal de Goiás, Praça Universitária, S/N, Setor Universitário, Goiânia-Goiás, CEP 74605-220, Brazil.
    Background: Granular cell tumor is a rare benign tumor that can present a pseudoepitheliomatous hyperplasia of the covering epithelium. This lesion is not encapsulated and can be characterized by a pseudo invasive growth pattern, represented by the tumoral cells that infiltrate between adjacent connective tissue elements. Diagnostic difficulties may arise because histopathological features of the pronounced pseudoepitheliomatous hyperplasia can be confused with a well-differentiated oral squamous cell carcinoma. Read More
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    Oncocytic Pleomorphic Adenoma of Palatal Salivary Gland with Macrophages and Giant Cells Associated with Cholesterol Crystals.
    Clin Pract 2016 Oct 24;6(4):884. Epub 2016 Oct 24.
    Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University , Saudi Arabia.
    Pleomorphic adenoma (PA) is the most common salivary gland tumor characterized by histo-morphological diversity in the form of myxoid, hyalinized, chondroid, osseous, and squamous areas. In this paper, we report a rare case of predominantly oncocytic variant of PA in a 45-year-old male patient on the posterior palatal region. Microscopic examination showed homogenous eosinophilic cellular mass composed of epithelial components arranged in the form of tubular and solid patterns. Read More
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    Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect.
    Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e31-e35. Epub 2017 Jan 1.
    Av. Professor Lineu Prestes, 2227, Cidade Universitária, 05508-000- São Paulo, SP, Brazil,
    Background: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses. Read More
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    Esophageal Granular Cell Tumor: A Case Report and Review of Literature.
    Cureus 2016 Sep 14;8(9):e782. Epub 2016 Sep 14.
    Department of Gastroenterology, Staten Island University Hospital.
    Granular cell tumors (GCTs) are soft tissue neoplasms that originate from Schwann cells. They occur predominantly in the oral cavity, skin, and breast tissues. Gastrointestinal GCTs are very rare, accounting for only eight percent of all GCTs, most of which are located in the esophagus. Read More
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    S-100 Negative Granular Cell Tumor (So-called Primitive Polypoid Non-neural Granular Cell Tumor) of the Oral Cavity.
    Head Neck Pathol 2017 Sep 5;11(3):404-412. Epub 2016 Oct 5.
    Department of Oral and Maxillofacial Surgery, University of Washington School of Dentistry, B-204 Magnuson Health Sciences Center, 1959 NE Pacific Street, Box 357133, Seattle, WA, 98195, USA.
    Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Read More
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    An infrequent histopathological subtype of ameloblastoma: Adenoid granular cell ameloblastoma with dentinoid.
    Dent Res J (Isfahan) 2016 Jul-Aug;13(4):376-8
    Department of Oral and Maxillofacial Radiology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
    Adenoid ameloblastoma with dentinoid is a rare odontogenic tumor. Granular cell ameloblastoma also is a less common histological subtype of ameloblastoma. In this report, the patient was a 31-year-old male. Read More
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    A study of cell proliferation using immunohistological staining: A case report of congenital granular cell epulis.
    Int J Pediatr Otorhinolaryngol 2016 Sep 30;88:58-62. Epub 2016 Jun 30.
    Department of Physical Therapy, Baltimore City Community College, Baltimore, MD, USA.
    An unusual case of a 1-day-old Chinese female neonate with a solid tumor mass in the maxillary anterior ridge of the edentulous jaw is reported. Based on the clinical and histopathological features, the diagnosis was of obstructive congenital granular cell epulis (CGCE) which is an uncommon benign tumor that preferentially develops in female infants. Immunohistochemical analysis of the lesion was performed and the rate of cell proliferation was determined by immunostaining with Ki-67 and PCNA, which showed labeling indexes of 11. Read More
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    Neurogenic tumors and tumor-like lesions of the oral and maxillofacial region: A clinicopathological study.
    Saudi Dent J 2016 Apr 10;28(2):76-9. Epub 2016 Feb 10.
    Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
    Objective: Oral and maxillofacial lesions of neural origin are rare soft tissue neoplasms. The aim of the present study is to review the epidemiological data of oral and maxillofacial neurogenic lesions submitted for diagnosis to our laboratory over a 31-year period (August 1984-March 2015).

    Materials And Methods: The available formalin-fixed embedded specimens, Hematoxylin and Eosin slides, demographic and clinical data were retrieved. Read More
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    Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.
    Head Neck 2016 08 16;38(8):E2467-70. Epub 2016 Jun 16.
    Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
    Background: Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in the maxilla of an adolescent girl.

    Methods And Results: A 16-year-old female patient presented with palatal swelling. Read More
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    Central granular cell odontogenic tumor: Report of an unusual case.
    Indian J Dent Res 2016 Mar-Apr;27(2):220-222
    Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India.
    Central granular cell odontogenic tumor (CGCOT) is an unusual benign odontogenic neoplasm characterized by the presence of granular cells associated with apparently inactive odontogenic epithelium. These tumors tend to occur in the posterior mandible and usually present as well-defined unilocular or multilocular radiolucent lesions. So far, only <40 cases of CGCOT have been described in the literature under various terminologies. Read More
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    Lack of Utility of Cytokeratins in Differentiating Pseudocarcinomatous Hyperplasia of Granular Cell Tumors from Oral Squamous Cell Carcinoma.
    Asian Pac J Cancer Prev 2016 ;17(4):1785-7
    Oral Medicine and Orofacial Pain Center, University of Southern California, Los Angeles, California USA E-mail :
    Granular cell tumor (GCT) of the oral cavity is a benign lesion. Half of oral GCTs demonstrate pseudocarcinomatous hyperplasia (PCH) of the mucosa which can mimic invasive islands of oral squamous cell carcinoma (SCC). Such similarity can be confusing when diagnosing or evaluating the two conditions, potentially leading to misdiagnosis or misclassification. Read More
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    Granular cell tumor in two oral anatomic sites.
    Eur Arch Otorhinolaryngol 2016 Oct 23;273(10):3439-41. Epub 2016 Mar 23.
    Postgraduate Program in Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte, Avenida Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59.056-000, Brazil.
    Granular cell tumor (GCT) is an uncommon benign soft tissue neoplasm, which usually presents as a solitary nodule, appearing especially in the tongue. There are few cases of multiple oral GCT in the English-language literature, with only three cases reported in the last 20 years. This report describes a case of two oral GCT in a young patient and provides a literature review from 1995 to 2015. Read More
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    Immunohistochemical expression of Bcl-2 in oral epithelial dysplasia and oral squamous cell carcinoma.
    Indian J Cancer 2015 Oct-Dec;52(4):505-10
    Department of Oral Pathology, I.T.S. Centre for Dental Sciences and Research, Murad Nagar, Ghaziabad, Uttar Pradesh, India.
    Background: The B cell lymphoma-2 gene is a proto-oncogene whose protein product inhibits apoptosis. Its role is associated with keeping cells alive, but not by stimulating them to proliferation, as other proto-oncogenes do. Increased expression of protein product of Bcl-2 gene appears in the early phase of carcinogenesis leading to apoptosis impairment and in consequence to the progression of neoplastic changes. Read More
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    Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review.
    Case Rep Pathol 2016 3;2016:8043183. Epub 2016 Jan 3.
    Department of Dermatology, Başkent University School of Medicine, 06490 Ankara, Turkey.
    Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Read More
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    Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma.
    J Dermatol Case Rep 2015 Dec 31;9(4):89-97. Epub 2015 Dec 31.
    Department of Dermatology, Medical University of Warsaw, Poland; ; Departmet of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
    Squamous cell carcinoma is the second most common cutaneous malignancy after basal cell carcinoma. Although the gold standard of diagnosis for squamous cell carcinoma is biopsy followed by histopathology evaluation, optical non-invasive diagnostic tools have obtained increased attention. Dermoscopy has become one of the basic diagnostic methods in clinical practice. Read More
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    Granular cells in ameloblastoma: An enigma in diagnosis.
    Indian J Dent 2015 Oct-Dec;6(4):211-4
    Department of Oral Pathology, SGT Dental College and Hospital, Gurgaon, New Delhi, India.
    Ameloblastoma is an epithelial odontogenic tumor exhibiting diverse microscopic pattern that occurs singly or in combination with other patterns. This article describes a case of granular cell ameloblastoma (GCA) involving mandible in a 55-year-old male. The possibility of granular component is there in other odontogenic and nonodontogenic lesions. Read More
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    Cutaneous Granular Cell Tumor on the Arm in a Middle-Aged Man.
    J La State Med Soc 2015 Nov-Dec;167(6):252-3. Epub 2015 Dec 15.
    Dr. Crandall is affiliated with the Naval Medical Center, San Diego, CA.
    Granular Cell Tumors are uncommon, often benign neoplasms that occur primarily in the oral cavity. Granular Cell Tumors have also been reported in breast, gastrointestinal tissues, and less commonly in the dermis of the upper extremities. This is a case presentation of a 44-year-old Caucasian male with an asymptomatic Granular Cell Tumor on his right arm. Read More
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    Congenital granular cell lesion of the tongue: a report of two cases and review of the literature.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Jul 21;122(1):e14-8. Epub 2015 Oct 21.
    Chief, Division of Oral and Maxillofacial Pathology, Department of Dental Medicine, Hofstra North Shore-LIJ, School of Medicine, New Hyde Park, NY, USA.
    The congenital granular cell lesion most commonly occurs on the maxillary or mandibular alveolus of neonates. Extra-alveolar congenital granular cell lesion is exceptionally rare, with only 10 cases reported. Two additional cases occurring on the tongue are presented with a description of the clinical, histopathologic, and immunohistochemical features. Read More
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    S-100 Negative Granular Cell Tumor of the Oral Cavity.
    Head Neck Pathol 2016 Sep 7;10(3):367-73. Epub 2015 Dec 7.
    Department of Diagnostic Sciences, College of Dental Medicine, #7377, Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL, 33328-2018, USA.
    Classic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. Read More
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    Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature.
    Oncol Lett 2015 Aug 29;10(2):887-890. Epub 2015 May 29.
    Department of Pathology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430072, P.R. China.
    Small cell neuroendocrine carcinoma (SNEC) of the oral cavity is a rare and distinctive tumor with aggressive clinical behavior. Thus far, only a small number of cases have been reported and no definitive standard treatment strategy has been determined. The current study reports a case of oral SNEC arising in the lower gingiva in a 73-year-old male. Read More
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    Granular Cell Tumors on Unusual Anatomic Locations.
    Yonsei Med J 2015 Nov;56(6):1731-4
    Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic locations, such as palm, arm, thigh, finger, and vulvar area. Read More
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    Granular Cell Tumor: An Uncommon Benign Neoplasm.
    Indian J Dermatol 2015 May-Jun;60(3):322
    Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.
    Granular cell tumor is a distinctly rare neoplasm of neural sheath origin. It mainly presents as a solitary asymptomatic swelling in the oral cavity, skin, and rarely internal organs in the middle age. Histopathology is characteristic, showing polyhedral cells containing numerous fine eosinophilic granules with indistinct cell margins. Read More
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    Interplay Between MMP-9 and TIMP-2 Regulates Ameloblastoma Behavior and Tooth Morphogenesis.
    Appl Immunohistochem Mol Morphol 2016 May-Jun;24(5):364-72
    Department of Oral and Maxillofacial Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the local invasiveness of ameloblastoma. This study aims to assess the role of MMP-9 and TIMP-2 in regulating tumor progression in ameloblastomas, taking tooth germs as control. Formalin-fixed, paraffin-embedded tissue sections of 4 tooth germs and 32 ameloblastomas were immunohistochemically examined using antibodies against MMP-9 and TIMP-2. Read More
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    Congenital granular cell tumor - a rare entity.
    J Neonatal Surg 2015 Apr-Jun;4(2):17. Epub 2015 Apr 1.
    Dept of General Surgery, Peoples College of Medical Sciences, Bhanpur bypass road, Bhopal.
    Congenital granular cell tumor is a rare benign neoplastic growth affecting the gingival mucosa of neonates. Prenatal ultrasound diagnosis has recently come to focus and in spite of several reports on immune-histochemical and other advanced marker studies, the cause and origin of the lesion remains debatable till date. Review of literature on prenatal diagnosis and histopathology along with immunohistochemistry is discussed. Read More
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    Aggressive granular cell ameloblastoma: Report of a rare case.
    J Pharm Bioallied Sci 2015 Apr;7(Suppl 1):S276-8
    Department of Oral Pathology and Microbiology, Kalinga Institute of Dental Sciences, Bhubaneshwar, Odisha, India.
    Granular cell ameloblastoma is a slow growing odontogenic ectodermal tumor. The tumor shows typical ameloblastoma with the cells showing eosinophilic granularity. This variant of ameloblastoma is aggressive with high recurrence rates. Read More
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    Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology.
    PLoS One 2015 11;10(5):e0125598. Epub 2015 May 11.
    Biomedical Engineering Department, University of Arkansas, Fayetteville, Arkansas 72701, United States of America.
    Proflavine hemisulfate, an acridine-derived fluorescent dye, can be used as a rapid stain for cytologic examination of biological specimens. Proflavine fluorescently stains cell nuclei and cytoplasmic structures, owing to its small amphipathic structure and ability to intercalate DNA. In this manuscript, we demonstrated the use of proflavine as a rapid cytologic dye on a number of specimens, including normal exfoliated oral squamous cells, cultured human oral squamous carcinoma cells, and leukocytes derived from whole blood specimens using a custom-built, portable, LED-illuminated fluorescence microscope. Read More
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    Effect of Phenylephrine Pretreatment on the Expressions of Aquaporin 5 and c-Jun N-Terminal Kinase in Irradiated Submandibular Gland.
    Radiat Res 2015 Jun 7;183(6):693-700. Epub 2015 May 7.
    a  Department of Oral Medicine and Medical Research Center, Medical College, Dalian University, Dalian 116622, P.R. China;
    Radiotherapy for malignant tumors of the head and neck commonly leads to radiation-induced sialadenitis as a result of radiation-induced salivary gland dysfunction. We demonstrated previously that phenylephrine could protect the irradiated submandibular gland against apoptosis, although the mechanism is unclear. In this study, we investigated the influence of phenylephrine pretreatment on the expressions of aquaporin 5 (AQP5) and c-Jun N-terminal kinase (JNK) that were presumed to have a role in radiation-induced salivary gland dysfunction. Read More
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    Multiple granular cell tumors with metachronous occurrence in tongue and vulva. Clinicopathological and immunohistochemical study.
    J Oral Maxillofac Pathol 2014 Sep-Dec;18(3):437-41
    Department of Pathology, University of Valencia, La Fe University Hospital, Valencia, Spain.
    Granular cell tumor (GCT) usually occurs as a single tumor, although sometimes multiple lesions can occur. In present report we analyze the clinicopathological and immunohistochemical features of a multiple GCT involving the tongue of a 14-year-old girl, with no other abnormalities, with a metachronous occurrence of a second GCT in vulva, after a period of 10 years. Both tumors revealed S-100, vimentin and CD57 positivity. Read More
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    Primary Merkel cell carcinoma of the oral mucosa in a young adult male: report of a rare case.
    Indian J Pathol Microbiol 2015 Apr-Jun;58(2):214-6
    Medical College, Kolkata, West Bengal, India.
    Merkel cell carcinoma (MCC) is a highly aggressive neoplasm of skin with neuroendocrine differentiation. Primary MCC of the oral mucosa is exceedingly rare and even more unresponsive to therapy. A 15-year-old male presents with gradually increasing painless swelling in right side of the floor of mouth for 6 weeks. Read More
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    Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27.
    J Invest Dermatol 2015 Jul 11;135(7):1801-1809. Epub 2015 Mar 11.
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.
    The fused-type S100 protein profilaggrin and its proteolytic products including filaggrin are important in the formation of a normal epidermal barrier; however, the specific function of the S100 calcium-binding domain in profilaggrin biology is poorly understood. To explore its molecular function, we determined a 2.2 Å-resolution crystal structure of the N-terminal fused-type S100 domain of human profilaggrin with bound calcium ions. Read More
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