2,188 results match your criteria Oral Fibromas and Fibromatoses


Ameloblastic Fibro-Odontoma.

Fetal Pediatr Pathol 2022 Jun 24:1-4. Epub 2022 Jun 24.

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Ameloblastic fibro-odontoma (AFO) is a benign odontogentic tumor without an aggressive behavior, unlike the similar ameloblastic fibroma. A 9-year-old boy, with tooth eruption failure, underwent enucleation and curettage of a well-defined variable radiolucent and radio-opaque right mandible lesion. There was odontogenic epithelium with peripheral palisading in a loose myxoid stroma as well as a disorganized component of dentin, enamel, and cementum, features of an AFO. Read More

View Article and Full-Text PDF

Recurrent Gingival Lesions in a Pediatric Patient.

Plast Reconstr Surg Glob Open 2022 Jun 15;10(6):e4382. Epub 2022 Jun 15.

Division of Plastic Surgery, Department of Surgery, University of Washington, Seattle, Wash.

We present the case of a 13-year-old girl who developed numerous gingival masses that recurred after two prior resections. Following the initial resection as a child, she reported that there was a period of resolution for several years before recurrence as a teenager. After the second resection, the masses recurred after 4 months. Read More

View Article and Full-Text PDF

Peripheral ossifying fibroma: A 20-year retrospective study with focus on clinical and morphological features.

Med Oral Patol Oral Cir Bucal 2022 Jun 19. Epub 2022 Jun 19.

Oral Pathology Section, Department of Oral Diagnosis University of Fortaleza (UNIFOR) Av. Washington Soares, 1321, Edson Queiroz, CE 60811-905, Fortaleza, Brazil

Background: Peripheral Ossifying Fibroma (POF) is a reactive hyperplastic lesion that exclusively occurs in the gingiva and is characterized by the deposition of dystrophic calcification, cementum-like tissue, and immature and mature bone within the connective tissue. The objective of the present study was to perform a retrospective analysis of clinicopathologic features of POF.

Material And Methods: Clinical and histopathological data were obtained from biopsy records and histopathological reports from a Brazilian reference service in Oral Pathology (1999 - 2020). Read More

View Article and Full-Text PDF

Clinicopathological Study of Biopsied Tongue Lesions Among 5284 Dental Outpatients in Southern Iran.

J Maxillofac Oral Surg 2022 Jun 23;21(2):307-311. Epub 2020 Sep 23.

Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Some studies have shown a high incidence of oral cancer among tongue biopsy specimens. This study aimed to determine the prevalence and distribution of tongue biopsied lesions in an Iranian population.

Methods: In this retrospective study, data from 5284 oral biopsy reports over a 22-year period (1996-2017) were evaluated regarding the type of lesions, location and patient's age and gender. Read More

View Article and Full-Text PDF

[A large maxillary fibroepithelial polyp: a lump in the throat].

Ned Tijdschr Tandheelkd 2022 Jun;129(6):289-292

A 55-year-old woman was seen at an oral and maxillofacial surgery department because of a large oral swelling and complaints about difficulty eating, nasal speech and fatigue. She had full dentures in her upper jaw. Intraorally, a pain-free, pedunculated, combined solid-elastic and bone-hard tumour was found in the left maxillary tubercle region. Read More

View Article and Full-Text PDF

Vascularized free fibula flap oral rehabilitation using tissue engineered mucosa: Report of 3 cases.

J Craniomaxillofac Surg 2022 Jun 28;50(6):485-492. Epub 2022 May 28.

Head & Neck Surgery, University College London Hospital (UCLH), 250 Euston Road, London, NW1 2PG, United Kingdom.

The aim of this report is to introduce the use of the dermal substitute Integra® in the context of free fibula flap prelamination for mandibular reconstruction. Three cases of mandibular reconstruction with prefabricated and Integra-prelaminated vascularized fibula flaps are reported in this article. The patients reported in this case series presented with the following tumours: an extensive cemento-ossyfying fibroma, a multicystic ameloblastoma and an extensive calcifying epithelial odontogenic tumour. Read More

View Article and Full-Text PDF

Dental MRI of Oral Soft-Tissue Tumors-Optimized Use of Black Bone MRI Sequences and a 15-Channel Mandibular Coil.

J Imaging 2022 May 22;8(5). Epub 2022 May 22.

Clinic of Cranio-Maxillofacial and Oral Surgery, Center of Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.

Soft-tissue lesions in the oral cavity, one of the most common sites for tumors and tumor-like lesions, can be challenging to diagnose and treat due to the wide spectrum from benign indolent to invasive malignant lesions. We report an abnormally large, rapidly growing hyperplastic lesion originating from the buccal mucosa in a 28-year-old male patient. Clinical examination revealed a well-circumscribed, smooth-surfaced, pinkish nodular lesion measuring 2. Read More

View Article and Full-Text PDF

Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.

Virchows Arch 2022 May 25. Epub 2022 May 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the RAS/MAPK pathway. However, NOF is located in the long bones with regression after puberty in contrast to CGCG which is located in the jaw bones and does not regress spontaneously. We hypothesised that endocrine regulation by oestrogen plays a role in the spontaneous regression in NOF. Read More

View Article and Full-Text PDF

Direct evidence supporting a periodontal ligament origin for central cemento-ossifying fibroma.

J Oral Pathol Med 2022 May 24. Epub 2022 May 24.

Department of Diagnostic Pathology, Tsurumi University Dental Hospital, Yokohama, Japan.

View Article and Full-Text PDF

Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.

Cells 2022 04 27;11(9). Epub 2022 Apr 27.

Department of Oral Biology and Diagnostic Sciences, The Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.

Adrenal glands are the major source of glucocorticoids, but recent studies indicate tissue-specific production of cortisol, including that in the oral mucosa. Both endogenous and exogenous glucocorticoids regulate the production of several proteins, including the glucocorticoid-induced leucine zipper (GILZ) and Annexin A1, which play important roles in the regulation of immune and inflammatory responses. Common inflammation-associated oral conditions include lichen planus and candidiasis, but the status of GILZ and Annexin A1 in these human conditions remains to be established. Read More

View Article and Full-Text PDF

Oral Pathology in Portuguese Dogs: An Eight-Year Biopsy-Based Retrospective Study.

J Vet Dent 2022 May 11:8987564221098107. Epub 2022 May 11.

Biopathology Unit, University Institute of Health Sciences (IUCS), 92909CESPU, Gandra, Portugal.

The oral cavity of the dog can be the site of several types of pathology including both benign and malignant lesions. The aim of this study was to analyze the frequency and clinical-pathological characteristics of oral lesions present in a cohort of Portuguese dogs. A retrospective observational cross-sectional study on 704 canine oral lesions submitted for histopathological diagnosis to a Veterinary Pathology Center in the north of Portugal from 2010 to 2017 was performed. Read More

View Article and Full-Text PDF

An Uncommon Presentation of Ossifying Fibroma in the Maxilla.

Cureus 2022 Mar 30;14(3):e23638. Epub 2022 Mar 30.

Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, IND.

Ossifying fibromas are rare, benign, nonaggressive fibro-osseous lesions that manifest in the craniofacial region. Ossifying fibromas are benign tumors of bone, commonly involving the posterior dentate mandible in middle-aged individuals with a female predilection. Clinical manifestations are an asymptomatic expansion of the dentate mandible, with infrequent maxillary lesions. Read More

View Article and Full-Text PDF

Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study.

Biomolecules 2022 04 16;12(4). Epub 2022 Apr 16.

Department of Clinical and Experimental Medicine, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy.

Fibrous dysplasia (FD) and hyperparathyroidism-jaw tumor syndrome (HPT-JT) are well-characterized benign bone fibro-osseous lesions. The intracellular mechanism leading to excessive deposition of fibrous tissue and alteration of differentiation processes leading to osteomalacia have not yet been fully clarified. Tissue Microarray (TMA)-based immunohistochemical expression of β-catenin, CK-AE1/AE3, Ki-67, cadherins and P-Runx2 were analyzed in archival samples from nine patients affected by FD and HPT-JT and in seven controls, with the aim of elucidating the contribution of these molecules (β-catenin, cadherins and P-Runx2) in the osteoblast differentiation pathway. Read More

View Article and Full-Text PDF

Benign mesenchymal odontogenic tumors of the maxillofacial bones: A report of 3 cases with 3 years follow-up.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S46-S50. Epub 2022 Feb 28.

Department of Oral Surgery, Beirut Arab University, Beirut, Lebanon.

Benign mesenchymal odontogenic tumors are lesions derived from the mesenchymal components of the tooth-forming apparatus and are consequently found within the jawbone. Benign fibro-osseous tumors are part of this category of lesions in which normal bone is substituted, initially by fibrous tissue and within time become infiltrated by osteoid and cementoid elements. They are asymptomatic, slow-growing lesions and remain undiagnosed until swelling of the face becomes prominent and they share similar radiological characteristics. Read More

View Article and Full-Text PDF
February 2022

Ameloblastic Fibro-Odontoma: A Journey of Progression?

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S40-S45. Epub 2022 Feb 28.

Department of Oral Pathology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.

A 19-year-old male patient reported to dental OPD of our institution with a swelling in the posterior part of the mandible on the left side. The patient gave a history of gradual increase in the size of swelling for 7 years. The patient also had a radiograph and histopathology slides from his previous dental visit at another facility. Read More

View Article and Full-Text PDF
February 2022

Inflammatory myofibroblastic tumor of anterior maxillary gingiva: An unusual clinical presentation.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S73-S76. Epub 2022 Feb 28.

Department of Dentistry, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Inflammatory myofibroblastic tumor (IMT) is a rare benign neoplasm with variable clinical presentation. We hereby present a case of a 27-year-old female who presented to us with an unsuspecting gingival overgrowth in her anterior gingiva. This article aims to describe IMT as a rare intraoral entity which may involve the anterior maxillary gingiva, involving or sparing the underlying bone, as only a handful of such cases have been reported so far. Read More

View Article and Full-Text PDF
February 2022

Small cell neuroendocrine carcinoma of buccal mucosa: Innocuous but invasive.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S91-S95. Epub 2022 Feb 28.

Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana, India.

Small cell neuroendocrine carcinoma (SNEC) was first described in the 19 century which is usually seen in association with lung cancer and is very rare in the oral cavity. Here, we report one such case in a 39-year-old male patient who presented with swelling on the left middle third of the face for 6 months. This is the 12 SNEC of oral cavity case so far reported in the English literature and the third case to be present on buccal mucosa. Read More

View Article and Full-Text PDF
February 2022

Combined lesion of central giant cell granuloma and ossifying fibroma: A case report of a rare event in oral cavity.

Int J Surg Case Rep 2022 May 14;94:107082. Epub 2022 Apr 14.

Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan. Electronic address:

Introduction And Importance: Giant cell granulomas (GCG) and ossifying fibroma (OF) of the jaw are benign reactive lesions. GCG characterized by the presence of abundant multinucleated giant cells in a cellular stroma. On the other hand, the characteristic feature of OF is benign connective tissue replaces the normal bone. Read More

View Article and Full-Text PDF

Odontogenic tumors: A Retrospective Study in Egyptian population using WHO 2017 classification.

Med Oral Patol Oral Cir Bucal 2022 May 1;27(3):e198-e204. Epub 2022 May 1.

Faculty of Dentistry Cairo University Elmanial Street, Cairo, Egypt

Background: Odontogenic tumors (OTs) are considered important among oral lesions because of their clinicopathological heterogeneity and variable biological behavior. The purpose of this retrospective cross-sectional study was to evaluate the frequency and distribution of different types of odontogenic tumors based on the current 2017 WHO Classification of Head and Neck Tumors over a period of 5 years. This was achieved by reviewing the records of Cairo's educational hospitals and institutions and comparing the results with findings in the literature. Read More

View Article and Full-Text PDF

"Endotracheal Tube" as a Temporary Method of Mandibular Reconstruction in Infant with Juvenile Ossifying Fibroma.

J Maxillofac Oral Surg 2022 Mar 3;21(1):293-295. Epub 2021 Jan 3.

Department of Cranio-Maxillofacial Surgery/Dentistry, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, Uttarakhand 134113 India.

View Article and Full-Text PDF

First isolation and identification of Cystobasidium calyptogenae from the oral samples of an elderly patient presenting with angular cheilitis.

Eur J Med Res 2022 Mar 27;27(1):48. Epub 2022 Mar 27.

Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Background: Angular cheilitis, an infection mainly caused by Candida yeasts, is featured by the appearance of inflammatory lesions at the bilateral corners of the mouth, particularly in patients with poor oral hygiene, ill-fitting dentures and old age. The first isolation of an atypical yeast, Cystobasidium calyptogenae, from oral samples of a patient presenting with angular cheilitis is discussed in this study.

Case Presentation: Angular cheilitis was diagnosed in a 60-year-old denture-wearing woman who presented with an irritation fibroma on her right lower buccal sulcus over the premolar region. Read More

View Article and Full-Text PDF

Atypical Presentation of Peripheral Ossifying Fibroma in the Mandible.

Cureus 2022 Feb 19;14(2):e22375. Epub 2022 Feb 19.

Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, IND.

Peripheral ossifying fibroma (POF) is a localized reactive enlargement of the gingiva often associated with the papilla and originate from underneath the periodontium. POF occurs predominantly in females, especially in the anterior maxillary region of young adults. The histopathological examination provides a confirmatory diagnosis of such lesions due to their heterogeneous clinical and radiographic characteristics. Read More

View Article and Full-Text PDF
February 2022

Oral irritation fibroma associated with the pathological migration of a primary tooth.

BMJ Case Rep 2022 Mar 16;15(3). Epub 2022 Mar 16.

Department of Odontostomatology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain

We report the case of a 3-year-old girl referred to our hospital dentistry service, from a public health centre, due to a 4-week-old swelling in the area of the hard palate, causing displacement of the deciduous tooth and the appearance of an interincisal diastema. The clinical characteristics suggested the possibility of a reactive fibroma and we decided to intervene surgically by means of an excisional biopsy. Histology confirmed the presumptive diagnosis. Read More

View Article and Full-Text PDF

Sorafenib in Dupuytren and Ledderhose Disease.

Oncologist 2022 03;27(3):e294-e296

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

Palmar and plantar fibromatosis are benign proliferative processes which present as a diffuse thickening or nodules of the hands and/or feet and may lead to flexion contractures, pain, and functional impairment known as Dupuytren and Ledderhose diseases, respectively. Current treatments are noncurative and associated with significant morbidity. Here, we report on the outcomes of 5 patients with advanced disease, no longer surgical candidates, treated with sorafenib. Read More

View Article and Full-Text PDF

Juvenile trabecular ossifying fibroma of the maxilla: Case report of a diagnostic dilemma.

Dent Res J (Isfahan) 2021 10;18:102. Epub 2021 Dec 10.

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Ossifying fibromas (OFs) are benign, well-demarcated lesions in the craniofacial region, particularly in the jaws, with clinical, radiographic, and histopathological similarities to other lesions, which make their diagnosis challenging. Herein, we report a case of a fibro-osseous lesion in the anterior maxilla of a 13-year-old boy, consisting of an intraosseous and an extra-osseous part, which created a diagnostic dilemma. Read More

View Article and Full-Text PDF
December 2021

Chondromyxoid fibroma of zygomatic bone: A case report.

Ann Med Surg (Lond) 2022 Mar 22;75:103394. Epub 2022 Feb 22.

Department of Oral and Maxillofacial Surgery, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Oujda, Morocco.

Introduction: Chondromyxoid fibroma (CMF) is a rare benign bone tumor that typically affects long bones, only 2% of CMFs involved facial bones or skull, zygomatic localization is extremely rare with only 8 cases reported in literature so far.

Presentation Of Case: We report a case of 88 old years patient with painful swelling in the right zygomatic around 1 year, progressively increasing in volume, Computed tomography (CT) scan showed an osteolytic lesion in the right zygomatic bone with cortical destruction. Surgical management consisted of bone curettage using intra oral approach, the histopahological findings were in favor of the diagnosis of CMF. Read More

View Article and Full-Text PDF

Immunohistochemical evaluation of IL-1β, IL-6, TNF-α and IL-17 cytokine expression in peripheral giant cell granuloma and peripheral ossifying fibroma of the jaws.

Arch Oral Biol 2022 Apr 21;136:105385. Epub 2022 Feb 21.

Department of Medical Pathology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey. Electronic address:

Objective: To examine and compare the immunohistochemical expressions of IL-1β, IL-6, IL-17 and TNF-α in peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF).

Design: The study included 20 POF and 20 PGCG cases diagnosed at the Pathology Department of Eskişehir Osmangazi University Medical Faculty. Hematoxylin & Eosin-stained slides obtained from each biopsy specimen were re-evaluated, and IL-1β, IL-6, IL-17 and TNF-α antibodies were investigated immunohistochemically. Read More

View Article and Full-Text PDF

Recurrent ossifying fibroma of the orbit - A case report.

Indian J Dent Res 2021 Jul-Sep;32(3):411-414

Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, 30, KB Dasan Road, Teynampet, Chennai, Tamil Nadu, India.

Rationale: Ossifying fibromas are mainly found in the jaws and are rare in other parts of the cranium. Orbital involvement is relatively rare.

Patient Details: A case of an otherwise healthy 38-year-old overseas patient with gradual onset of a large growth in the right ocular area involving adjacent bone and operated twice over the last eight years is being presented. Read More

View Article and Full-Text PDF

Accuracy of leukoplakia diagnoses: a retrospective study.

Gen Dent 2022 Mar-Apr;70(2):14-17

The objective of this study was to review the diagnostic accuracy of clinicians identifying leukoplakia and the diagnostic terminology used to indicate leukoplakic lesions at the University of Nebraska Medical Center (UNMC) oral biopsy service. Biopsy archives from the years 1983, 1995, 2005, and 2015 in the UNMC College of Dentistry were reviewed. Cases with a clinical diagnosis of leukoplakia (or white plaque), hyperkeratosis, dysplasia, and/or carcinoma were included in the study. Read More

View Article and Full-Text PDF

Role of MDM2, CDK4, BCL2, Parafibromin and Galectin 1 in Differentiating Osteosarcoma from its Benign Fibro-osseous Lesions.

Head Neck Pathol 2022 Feb 26. Epub 2022 Feb 26.

Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, Delhi, Pin 110029, India.

Benign fibro-osseous lesions (BFOLs) are a diverse group of lesions showing considerable degree of overlap with low grade osteosarcoma (LGOS). Further, de-differentiated osteosarcoma (DOS) is usually indistinguishable from conventional high-grade OS (COS) if LGOS foci are not identified. Thus, there is a need for adjunctive immunohistochemical markers to differentiate OS from benign FOLs as well as DOS from COS. Read More

View Article and Full-Text PDF
February 2022