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    1872 results match your criteria Oral Fibromas and Fibromatoses

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    Prevalence and Distribution of Oral Mucosal Lesions by Sex and Age Categories: A Retrospective Study of Patients Attending Lebanese School of Dentistry.
    Int J Dent 2018 17;2018:4030134. Epub 2018 May 17.
    Faculty of Pharmacy, Lebanese University, Beirut, Lebanon.
    Background: Prevalence and distribution of oral mucosal lesions in a sample of Lebanese population attending the School of Dentistry of Lebanese University is necessary to evaluate their oral health situation.

    Objectives: The aim of the present study was to determine the prevalence and distribution of oral mucosal lesions of patients attending the School of Dentistry.

    Methods: A descriptive study was carried out by retrospectively examining a total of 231 medical and clinical examination record files of patients, attending the School of Dentistry Lebanese University for multidisciplinary dental treatments. Read More

    Juvenile Trabecular Ossifying Fibroma-a Case Report.
    Indian J Surg Oncol 2018 Jun 21;9(2):260-264. Epub 2018 Apr 21.
    5Department of Oral and Maxillofacial Surgery Specialized, Babol University of Medical Sciences, Babol, Iran.
    Ossifying fibroma is a benign osteogenic mesenchymal tumor that is classified in the fibro-osseous lesions. Fibro-osseous lesions contain minerals, blood vessels, and giant cells that have the same radiographic and pathologic features but have different clinical behaviors, and were replaced with the normal bone. These lesions include fibrous dysplasia, cemento-osseous dysplasia, and ossifying fibroma. Read More

    Comparsion of staining characteristics of Toto bodies.
    Biotech Histochem 2018 May 21:1-4. Epub 2018 May 21.
    a Department of Oral and Maxillofacial Pathology , St. Joseph Dental College , Eluru 534004 , Andhra Pradesh , India.
    Toto bodies are eosinophilic structures that resemble the cells of the superficial cell layer of the oral epithelium. Toto bodies commonly are associated with inflammatory gingival and other mucosal lesions including pyogenic granuloma, irritational fibroma, epulis fissuratum, peripheral giant cell granuloma and inflammatory hyperplastic gingivitis. We evaluated staining characteristics of Toto bodies to establish their origin and to identify their significance in lesions. Read More

    The role of macrophages and eosinophils in reactive lesions of the oral cavity.
    J Oral Maxillofac Pathol 2018 Jan-Apr;22(1):147
    Department of Oral and Maxillofacial Pathology, Dental and Periodontal Research Centre, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Many studies have reported that macrophages and eosinophils are involved in the pathogenesis of several diseases. To the best of our knowledge, this is the first study comparing macrophages and eosinophils in oral reactive lesions.

    Aims: In this study, we aimed to determine the contribution of macrophages and eosinophils to the pathogenesis of oral reactive lesions and the relationships between these biomarkers and the diverse histopathologic features. Read More

    Incidence of reactive hyperplastic lesions in the oral cavity: a 10 year retrospective study in Santa Catarina, Brazil.
    Braz J Otorhinolaryngol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
    Introduction: Reactive hyperplastic lesions develop in response to a chronic injury simulating an exuberant tissue repair response. They represent some of the most common oral lesions including inflammatory fibrous hyperplasia, oral pyogenic granuloma, giant cell fibroma, peripheral ossifying fibroma, and peripheral giant cell lesions.

    Objective: The incidence of those lesions was investigated in an oral pathology service, and the clinical characteristics, associated etiological factors, concordance between the clinical and histopathological diagnostic was determined. Read More

    Oral Bilateral Collagenous Fibroma: A previously unreported case and literature review.
    J Clin Exp Dent 2018 Jan 1;10(1):e96-e99. Epub 2018 Jan 1.
    MSc, Post Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas-RS, Brazil.
    Collagenous fibroma, also known as desmoplastic fibroblastoma, is a rare benign slow growing tumor particularly uncommon in the oral cavity. The aim of this study was to analyze the clinical and histopathological features of an oral collagenous fibroma as well as to compare this data with those reported in an English-literature review. The thirteenth case of collagenous fibroma in the oral cavity and the first to present clinically as a bilateral mass was described. Read More

    Clinicopathological investigation of odontogenic fibroma in tuberous sclerosis complex.
    Int J Oral Maxillofac Surg 2018 Jul 10;47(7):918-922. Epub 2018 Apr 10.
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan.
    Tuberous sclerosis complex (TSC) is an autosomal dominant inherited disease characterized by systemic hamartoma and diverse systemic features. TSC1 and TSC2 are the causative genes, and mental retardation, epileptic seizures, and facial angiofibroma develop in many patients with the disease. The case of a patient with TSC who developed a central odontogenic fibroma of the mandible is reported here. Read More

    CT and MR imaging characteristics of histological subtypes of head and neck ossifying fibroma.
    Dentomaxillofac Radiol 2018 Apr 11:20180085. Epub 2018 Apr 11.
    1 Department of Radiology, Gifu University School of Medicine , Gifu , Japan.
    Objectives: The current study aimed to assess CT and MRI characteristics of histological subtypes of head and neck ossifying fibroma (OF).

    Methods: 12 patients with histopathologically-proven head and neck OF were included in this study. Lesions were pathologically classified into three histological subtypes: eight cement-OFs (COFs), three juvenile psammomatoid OFs (JPOFs), and one juvenile trabecular OF (JTOF). Read More

    Giant Peripheral Ossifying Fibroma of the Posterior Mandible-A Rare Case Report.
    Iran J Pathol 2017 1;12(4):397-401. Epub 2017 Oct 1.
    Dept. of Oral Pathology & Microbiology, Subharti Dental College & Hospital, Meerut, India.
    Large, atypical peripheral ossifying fibromas are known as giant peripheral ossifying fibromas. These lesions have often been associated with heterogeneous clinical and radiographic characteristics subsequently leading to their misdiagnosis. Biopsies have been the gold standard for the diagnosis of such lesions. Read More

    Large mandibular central odontogenic fibroma documented over 20 years: A case report.
    Int J Surg Case Rep 2017 24;41:481-488. Epub 2017 Nov 24.
    Centre for Oral and Maxillofacial Surgery, University of Dental Medicine and Oral Health, Danube Private University, Steiner Landstraße 124, 3500 Krems-Stein, Austria. Electronic address:
    Introduction: Central odontogenic fibroma (COF) is a rare, benign, slow-growing intraosseous odontogenic tumor, and accounts for 0.1% of all odontogenic tumors. It is often confused with other entities, such as keratocysts, ameloblastomas, and odontogenic myxomas. Read More

    Does a Vascularized Fibula Free Bone Grafted Immediately After Hemimandibulectomy in a Child Grow or Relapse During Adolescence?
    J Craniofac Surg 2018 Mar 8. Epub 2018 Mar 8.
    Section of Maxillofacial Surgery, Department of Maxillofacial and Neck Reconstruction.
    For young growing children before the end of skeletal maturity, the growth activity of the grafted bone after hemimandibulectomy is not well-known. After an adolescence, such a patient may have facial deformity because the anterior growth point of the mandible is in the condylar neck. A 13-year-old boy was performed hemimandibulectomy with immediate mandibular reconstruction by fibula free flap (FFF) because of a huge ameloblastic fibroma. Read More

    A curious case of central odontogenic fibroma: A novel perspective.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S16-S19
    Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
    We appraise a case of central odontogenic fibroma (COF) with unusual histologic features of entrapped neural elements and mast cells. The presence of mast cells attributed to the release of stem cell factor, the principal growth and activating factor of mast cells. A putative role for C-kit and mast cells in the pathogenesis of COF is described. Read More

    Fibrotic encapsulation of orthodontic appliance in palate.
    J Indian Soc Periodontol 2017 Sep-Oct;21(5):427-428
    Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India.
    Iatrogenic trauma though not serious is very common in dental practice. Orthodontic treatment can inflict such injuries as they are prolonged over a long period of time. Ill-fabricated orthodontic appliances, such as wires and brackets, or the patients' habits such as application of constant pressure over the appliance can traumatize the adjacent oral soft tissues. Read More

    Reactive lesions of oral cavity: A retrospective study of 659 cases.
    J Indian Soc Periodontol 2017 Jul-Aug;21(4):258-263
    Department of Oral and Maxillofacial Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.
    Objective: This study reviews, analyzes, and compares the demographic data, histopathological features and discusses the treatment and prognosis of reactive lesions (RLs).

    Materials And Methods: Retrospective study was performed on the departmental archives from July 2006 to July 2016 (total 5000 cases) comprising of 659 cases of RLs of the oral cavity. The recorded data included age, gender, size, site, duration, habits, etiology, histopathological diagnosis, treatment, and prognosis. Read More

    Reactive hyperplastic lesions of the oral cavity: A retrospective survey study and literature review.
    Indian J Dent Res 2018 Jan-Feb;29(1):61-66
    Department of Community Dentistry, MIDSR Dental College, Latur, India.
    Context: The reactive lesions are relatively common in the oral cavity because of the frequency with which the tissues are injured. They often result from a known stimulus or injury such as dental plaque, calculus, or foreign material.

    Aims: : The aim of this study was to review the clinicopathologic features of reactive hyperplastic lesions (RHLs) of the oral cavity at MIDSR, Dental College and Hospital, Latur, Maharashtra, and to compare these data with those of previously reported studies. Read More

    A Case Series of Fibro-Osseous Lesions of the Jaws.
    Kobe J Med Sci 2017 Dec 18;63(3):E73-E79. Epub 2017 Dec 18.
    Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
    The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Read More

    Giant-cell fibroma: Understanding the nature of the melanin-laden cells.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):429-433
    Department of Oral Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.
    Giant-cell fibroma is a localized, benign fibrous mucosal mass, which clinically mimics any other fibroepithelial growth, and its distinction from other lesions is on the basis of its peculiar histopathology. A case of giant-cell fibroma with stroma strewn with brown pigment-laden cells is presented herewith. Immunohistochemical staining aided with histochemical reaction to understand the origin of these cells was carried out. Read More

    Osteopontin expression and clinicopathologic correlation of oral hyperplastic reactive lesions: An institutional 6-year retrospective study.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):382-386
    Department of Periodontics, Post Graduate Institute of Dental Sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India.
    Background And Objective: Reactive proliferations of oral cavity comprise pyogenic granuloma (PG), fibrous hyperplasia (FH), peripheral ossifying fibroma (POF), and peripheral giant-cell granuloma (PGCG). They often pose diagnostic challenges due to their overlapping clinical and histopathological features. This study was conducted to determine the frequency and clinicopathological correlation of reactive hyperplastic lesions in the oral cavity reported in our institute and compared it with other previous studies. Read More

    Paediatric oral pathology in Thailand: a 15-year retrospective review from a medical teaching hospital.
    Int Dent J 2018 Jan 28. Epub 2018 Jan 28.
    Department of Pathology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
    Objectives: To determine whether the spectrum of oral pathology in children seen at a medical institution differs from studies derived from dental facilities.

    Methods: Oral biopsy records from paediatric patients (<16 years of age) were retrieved from the pathology archives at Chulalongkorn University Hospital over a period of 15 years. Lesions were categorised as inflammatory/reactive, tumour/tumour-like or cystic. Read More

    Granular cell tumors of the tongue: fibroma or schwannoma.
    Head Face Med 2018 Jan 3;14(1). Epub 2018 Jan 3.
    Department of Oral and Maxillofacial Surgery, Plastic Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
    Background: Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue. Read More

    Fibroma-like PEComa: A Tuberous Sclerosis Complex-related Lesion.
    Am J Surg Pathol 2018 Apr;42(4):500-505
    Departments of Pathology.
    Perivascular epithelioid cell tumor (PEComa), mesenchymal tumors morphologically characterized by epithelioid cells, coexpress melanocytic and muscle markers. Herein, we describe a heretofore-undescribed tuberous sclerosis complex (TSC)-related neoplasm, morphologically resembling a soft tissue fibroma-like lesion, but showing an immunophenotype resembling PEComa. We identified 3 soft tissue fibroma-like lesions in individuals with TSC. Read More

    Prospective study of the 532 nm laser (KTP) versus diode laser 980 nm in the resection of hyperplastic lesions of the oral cavity.
    Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e78-e85. Epub 2018 Jan 1.
    Dental School - University of Seville C/ Avicena s/n 41009 Sevilla, SPAIN,
    Background: The aim of this study is to evaluate the resection of hyperplastic lesions on the buccal mucosa comparing the 532nm laser (KTP), versus diode 980nm laser, considering pain, scarring, inflammation and drug consumption that occurred postoperatively with each lasers.

    Material And Methods: A prospective study of consecutive series of 20 patients in two groups that presents hyperplastic lesions on the buccal mucosa. The choice of the KTP laser or diode 980nm laser for the surgery was made randomly. Read More

    Ameloblastic Fibro-odontoma with a Predominant Radiopaque Component.
    Ann Maxillofac Surg 2017 Jul-Dec;7(2):304-307
    Department of Oral and Maxillofacial Surgery, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
    Ameloblastic fibro-odontoma (AFO) is a rare odontogenic tumor. Initially believed to be a lesion similar to ameloblastic fibroma (AF), it is now considered as a separate entity in the WHO odontogenic tumor classification. Commonly associated with a painless swelling and an associated absence of eruption of a tooth, AFO presents as a mixed radiopaque and radiolucent lesion in the younger population with a predilection for the posterior region. Read More

    The Wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 02 24;125(2):172-178. Epub 2017 Nov 24.
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. Electronic address:
    Objective: The molecular pathogenesis of cemento ossifying fibroma (COF) is unclear. The purpose of this study was to investigate mutations in 50 oncogenes and tumor suppressor genes, including APC and CTNNB1, in which mutations in COF have been previously reported. In addition, we assessed the transcriptional levels of the Wnt/β-catenin pathway genes in COF. Read More

    Gingival fibroma versus verrucous leukoplakia - A clinical dilemma!!!
    J Indian Soc Periodontol 2016 Nov-Dec;20(6):635-637
    Department of Periodontics, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India.
    Gingival overgrowths found in the oral cavity are mostly due to reactive hyperplasia and rarely depict neoplastic nature. It is a challenge for the clinician to give final diagnoses of gingival overgrowth. Gingiva is a common site for various benign and malignant lesions. Read More

    Hyper Parathyroidisim Jaw Tumor Syndrome: A Rare Condition of Incongruous Features.
    Ethiop J Health Sci 2017 May;27(3):309-313
    Department of Oral Medicine and Radiology, Sree Mookambika Institute of Dental Sciences, Tamilnadu, India.
    Background: Hyperparathyroidism-Jaw Tumor (HPT-JT) syndrome is a rare genetic disorder bearing both a germline and a somatic CDC73 mutation (formerly known as HRPT2), which has been mapped to chromosome 1q25-q31. The association of jaw ossifying fibroma with primary hyperparathyroidisim (PHPT) is typical of HPT-JT. It may also include cystic and neoplastic renal abnormalities and uterine tumors. Read More

    Fibroepithelial Polyp with Sebaceous Hyperplasia: A Case Report.
    Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):404-406
    Private Practitioner, New Delhi, India.
    Fibro epithelial Polyp (FEP) is a polypoid outgrowth of epidermis and dermal fibro vascular tissue. This polyp is most commonly found in oral cavity, neck and axilla, though any skin fold may be affected like groin area. We describe a case of a 25-year-old male patient with a growth over the anterior rugae region of hard palate since 3 years. Read More

    Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation.
    Iran J Med Sci 2017 Nov;42(6):603-606
    Department of Oral and Maxillofacial Pathology and Microbiology, D Y Patil University School of Dentistry, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
    Juvenile ossifying fibroma (JOF) is a rare, benign, locally aggressive entity of the extragnathic craniofacial bones with a high tendency towards recurrence. Two distinctive microscopic patterns of juvenile ossifying fibroma have been described: a trabecular juvenile ossifying fibroma (TrJOF) and a psammomatoid juvenile ossifying fibroma (PJOF). Psammomatoid variant is predominantly a craniofacial lesion and occurs rarely in the jaws. Read More

    Comparison of verdeluz orange G and modified Gallego stains.
    Biotech Histochem 2017 21;92(8):547-551. Epub 2017 Nov 21.
    a Department of Oral and Maxillofacial Pathology , St. Joseph Dental College , Eluru , Andhra Pradesh , India.
    Tumors of the oral cavity include combinations of hard and soft tissues that may be difficult to identify using routine hematoxylin and eosin (H & E) staining. Although combination stains can demonstrate hard and soft tissues, trichrome stains, such as VanGieson and Masson, cannot differentiate dental hard tissues, such as dentin, cementum and osteoid. Modified Gallegos (MGS) and verdeluz orange G-acid fuchsin (VOF) stains can differentiate components of teeth. Read More

    Trabecular Variant Juvenile Ossifying Fibroma of the Maxilla.
    Cureus 2017 Sep 14;9(9):e1684. Epub 2017 Sep 14.
    Oral and Maxillofacial Surgery, Thai moogambigai dental college & hospital.
    Juvenile ossifying fibroma (JOF) is a benign, bone-forming neoplasm occurring primarily in children and adolescents. JOF is an aggressive variant of ossifying fibroma of the jaw with a variable clinical behavior and a high tendency for recurrence. Early detection and prompt treatment are required to treat JOF successfully. Read More

    Clinicopathological Characteristics and Prognosis of Ossifying Fibroma in the Jaws of Children: A Retrospective Study.
    J Cancer 2017 30;8(17):3592-3597. Epub 2017 Sep 30.
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 22# Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.
    : Ossifying fibroma in the jaws is a benign tumor and easily recurs in children, of which the treatment methods and prognosis still remain controversial. In this study, we aimed to review the clinicopathological characteristics, treatment, and prognosis of ossifying fibroma in the jaws of children, and offer recommendations for clinical decision-making. A retrospective study was carried out on patients below the age of 18 years with ossifying fibroma in the jaws. Read More

    Epidemiological and Clinicopathological Analysis of 92 Odontogenic Tumors: A 5-year Retrospective Study.
    J Contemp Dent Pract 2017 Nov 1;18(11):1056-1060. Epub 2017 Nov 1.
    Department of Orthodontics, Vidarbha Youth Welfare Society Amravati's Dental College & Hospital, Amravati, Maharashtra, India.
    Introduction: Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/ or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. Read More

    Metachronous ameloblastic fibro-odontoma and dentigerous cyst in the posterior mandible.
    Gen Dent 2017 Nov-Dec;65(6):69-72
    An ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor with histologic features of an ameloblastic fibroma in conjunction with the presence of dentin and enamel. It usually appears as a well-circumscribed radiolucency with radiopaque foci and slow growth and is commonly seen in children and young adults. A 13-year-old boy presented with an asymptomatic swelling in the posterior right region of the mandible and the right ascending ramus. Read More

    Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst.
    J Stomatol Oral Maxillofac Surg 2018 Apr 24;119(2):140-144. Epub 2017 Oct 24.
    Dental faculty, university of Strasbourg, 8, rue Sainte-Elisabeth, 67000 Strasbourg, France; Oral Surgery and Oral Medicine unit, Dental Clinic, Hôpital Civil, University Hospital of Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France; "Osteoarticular and Dental Regenerative Nanomedicine" laboratory, UMR 1109, Faculté de Médecine, FMTS, Inserm (French National Institute of Health and Medical Research), 67085 Strasbourg cedex, France. Electronic address:
    Ossifying fibroma (OF) is a benign fibro-osseous lesion mainly occurring in young adults and seems to originate from the periodontal ligament. Aneurysmal bone cyst (ABC) is a benign intraosseous lesion characterized by blood-filled spaces of various sizes. These two lesions can specifically affect the jaws and are commonly described in the literature. Read More

    Gorlin-Goltz syndrome.
    Turk Pediatri Ars 2017 Sep 1;52(3):173-177. Epub 2017 Sep 1.
    Department of Oral and Maxillofacial Radiology, Abant İzzet Baysal University Faculty of Dentristry, Bolu, Turkey.
    Gorlin-Goltz syndrome is a rare multisystemic disease inherited in an autosomal dominant pattern. It is characterized by numerous basal cell carcinoma of the skin, jaw cysts, and skeletal anomalies such as frontal bossing, vertebral anomalies, palmoplantar pits, and falx cerebri calcification. There is a tendency to tumors including medullablastoma, fibroma, rabdomyoma, leiomyosarcoma etc. Read More

    MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma.
    J Oral Pathol Med 2018 Jan 1;47(1):78-85. Epub 2017 Nov 1.
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
    Background: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Read More

    Juvenile Trabecular Ossifying Fibroma.
    Head Neck Pathol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, 21201, USA.
    Benign fibro-osseous lesions within the maxillofacial region represent a heterogeneous group of benign entities with overlapping histologic features. Ossifying fibroma, the rarest of these entities, represents a true neoplasm. Juvenile ossifying fibroma (JOF) is considered an aggressive rapidly growing sub-type. Read More

    Melanotic Macule in Conjunction with a Giant Cell Fibroma.
    J Contemp Dent Pract 2017 Oct 1;18(10):981-985. Epub 2017 Oct 1.
    Department of Periodontology, Lake Erie College of Osteopathic Medicine, School of Dental Medicine, Bradenton, Florida, USA, Phone: +9414051506, e-mail:
    Introduction: The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz-Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules. Read More

    Peripheral odontogenic fibroma: a rare gingival neoplasm with clinico-pathological differential diagnosis.
    J Exp Ther Oncol 2017 Sep;11(1):17-21
    Department of Oral Medicine and Radiology, Government Dental College and Hospital, Nagpur, India.
    Objective: The peripheral odontogenic fibroma (POdF) is a rare gingival neoplasm, characterised by relatively mature collagenous fibrous tissue and varying amounts of odontogenic epithelium. It can be described as a slow growing, firmly attached, solid and smooth gingival mass which may be present asymptomatically for years, which may cause displacement of adjacent teeth. The purpose of this article is to discuss a case of POdF, occurring in the maxillary anterior region, with detailed clinico-pathological differential diagnosis to clarify characteristic features of various gingival overgrowths to enhance easy identification. Read More

    Jaw Pain as a First Presentation in the Diagnosis of Breast Cancer.
    Iran J Pathol 2016 24;11(5):439-442. Epub 2017 Dec 24.
    Det. of Clinical Pharmacy, School of Pharmacy-International Campus, Endocrine Research Center, Institute of Endocrinology and Metabolism, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
    The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, was referred to the Department of Medical Oncology of Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2014, presented with pain and tenderness in the left mandibular and temporal bone and paresthesia of the lower left lip and chin. Read More

    Odontogenic Fibroma of the Maxilla - An Atypical Presentation.
    Iran J Pathol 2016 24;11(5):435-438. Epub 2016 Dec 24.
    Dept. of Prosthodontics, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Lucknow, U.P, India.
    Odontogenic fibroma (OF) is considered an unusual, benign mesenchymal neoplasm and one of the most little-understood lesions amongst all odontogenic neoplasms. The incidence rate of the tumor is from 0% to 5.5%. Read More

    An unusual case of neural palatal swelling.
    Int J Health Sci (Qassim) 2017 Jul-Sep;11(3):71-73
    Department of Oral and Maxillofacial Surgery, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
    Neural tumors in the oral cavity occur both in the soft tissues and in the jaw bones. They occur as painless, smooth surface swelling in the soft tissues of the mouth, exhibiting a slow rate of growth and mild expansion of the cortical plates. Here, we report a rare case of a cellular variant of schwannoma in a young Indian female patient who presented with an asymptomatic nodule in the mid-palatine raphe region of the hard palate, mimicking a fibroma, thus creating a dilemma in the diagnosis. Read More

    Multiple Recurrent Fibromatosis With Cranial Fasciitis Characteristics in a Pediatric Patient.
    J Craniofac Surg 2017 Oct;28(7):1821-1823
    *School of Medicine, Duke University †Department of Surgery, Division of Oral, Maxillofacial, and Plastic Surgery, Duke University ‡Department of Surgery, Division of Pediatric Neurosurgery, Duke University, Durham, NC.
    Cranial fasciitis is a rare, rapidly growing, but benign fibroblastic tumor of the skull that generally presents in childhood. Local resection or curettage of the affected bone is generally curative and the tumor is thought not to recur. Cranial fasciitis is distinguished by positive cytoplasmic and nuclear beta-catenin staining. Read More

    Ameloblastic Fibroodontoma: Uncommon Case Presentation in a 6-Year-Old Child with Review of the Literature.
    Case Rep Med 2017 13;2017:9483738. Epub 2017 Aug 13.
    Department of Oral Pathology, Faculty of Dentistry, Asian Institute of Medicine, Science & Technology (AIMST) University, Kedah Darul Aman, Malaysia.
    Ameloblastic fibroodontoma is a benign mixed odontogenic neoplasm considered in patients with asymptomatic swelling and unerupted teeth that exhibit histologic features between ameloblastic fibroma and complex odontoma. Radiographically, this lesion appears as radiolucency admixed with focal radio opaque masses of irregular shapes and sizes. This lesion is confirmed by the presence of proliferating odontogenic epithelium, ectomesenchyme, and dental hard tissue formation on pathological analysis supplementing clinical and radiographic findings. Read More

    Aggressive fibromatosis of the oral cavity in a 5 year old boy: a rare case report.
    Pan Afr Med J 2017 18;27:47. Epub 2017 May 18.
    Department of Oral Medicine and Radiology Bapuji Dental College and Hospital MCC B Block, Davangere, Karnataka, India.
    Fibrous tissue proliferations express a wide spectrum of histologic and morphologic variation in both infants and adults. This ranges from hypertrophic scar formation at one end to malignant fibrosarcoma at the other end of the spectrum. Aggressive fibromatosis is an intermediate tumor which is in proximity to fibrosarcomas. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Hybrid Central Odontogenic Fibroma with Giant Cell Granuloma like Lesion: A Report of Three Additional Cases and Review of the Literature.
    Head Neck Pathol 2018 Jun 7;12(2):166-174. Epub 2017 Aug 7.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.
    Central odontogenic fibroma (COF) is an uncommon intraosseous neoplasm of the gnathic bones which is composed of fibrous connective tissue, with or without calcifications, and variable amounts of inactive odontogenic epithelium. It makes up less than 5% of odontogenic tumors and is more commonly seen in females. Central giant cell granuloma (CGCG) is a locally destructive but benign lesion of the jaws containing osteoclast-like multinucleated giant cells in a fibrovascular stroma. Read More

    Ameloblastic fibroma and ameloblastic fibrosarcoma: A systematic review.
    J Oral Pathol Med 2018 Apr 2;47(4):315-325. Epub 2017 Sep 2.
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
    Purpose: To integrate the available data published to date on ameloblastic fibromas (AF) and ameloblastic fibrosarcomas (AFS) into a comprehensive analysis of their clinical/radiological features.

    Methods: An electronic search was undertaken in July 2017. Eligibility criteria included publications having enough clinical, radiological and histological information to confirm a definite diagnosis. Read More

    A delayed presentation of ameloblastic fibrosarcoma in an African patient.
    BMJ Case Rep 2017 Aug 1;2017. Epub 2017 Aug 1.
    Department of Plastic and Reconstructive Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
    A 24-year-old womanpresented with ameloblastic fibrosarcoma arising from ameloblastic fibroma. The delayed presentation accounted for the extensive destruction of the mandible and complete occlusion of her oral cavity. This resulted in an inability to eat and maintain oral hygiene. Read More

    Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jan 16;125(1):59-73.e2. Epub 2017 Jun 16.
    Department of Oral Medicine and Dentistry, Brigham and Women's Hospital, Harvard School of Dental Medicine, Boston, MA, USA. Electronic address:
    Objectives: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC.

    Study Design: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC. Cultured human keratinocyte lines from benign oral mucosa, OED, and OSCC, as well as a murine model in which OSCC was induced with 4-nitroquinoline-1-oxide, were also evaluated. Read More

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