2,023 results match your criteria Oral Fibromas and Fibromatoses


Ossifying fibroma in the maxilla and orbital floor: report of an uncommon case.

J Korean Assoc Oral Maxillofac Surg 2020 Jun;46(3):204-207

Department of Diagnosis and Maxillofacial Surgery, São Paulo State University (UNESP) Dental School, Araraquara, Brazil.

Benign fibro-osseous lesions occur when normal bone is replaced by cellular fibrous connective tissue and mineralized structures. One rare type of these lesions is the ossifying fibroma (OF). The aim of this study is to report an unusual case of OF in a 57-year-old female. Read More

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http://dx.doi.org/10.5125/jkaoms.2020.46.3.204DOI Listing

Diode laser-assisted management of intraoral soft tissue overgrowth: a case series.

Gen Dent 2020 Jul-Aug;68(4):28-31

The conventional method of managing intraoral soft tissue overgrowth involves surgical excision using a scalpel under local anesthesia. These procedures are often associated with excessive bleeding that leads to complications. Now, minimally invasive methods such as laser excision are available for the management of intraoral soft tissue lesions. Read More

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Hybrid Odontogenic Tumor of Calcifying Odontogenic Cyst and Ameloblastic Fibroma: a Case Report and Review of Literature.

J Dent (Shiraz) 2020 Jun;21(2):153-157

Postgraduate student, Dept. of Endodontics, Faculty of Dentistry, Tehran Medical Science Islamic Azad University, Tehran, Iran.

Calcifying odontogenic cyst is an uncommon odontogenic lesion that represents less than 2% of all odontogenic cysts and tumors. It usually occurs in incisor and canine areas during the second to fourth decades of life. It can be associated with other lesions like odontoma, ameloblastic fibroma, ameloblastoma, adenomatoid odontogenic tumors, odontoameloblastoma, and odontogenic myxoma. Read More

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http://dx.doi.org/10.30476/DENTJODS.2019.77806.DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280542PMC

A Clinicopathologic Analysis of 135 Cases of Cemento-Osseous Dysplasia: To Operate or Not to Operate?

J Stomatol Oral Maxillofac Surg 2020 Jun 18. Epub 2020 Jun 18.

Associate Professor, Istanbul University, Institute of Oncology, Department of Tumour Pathology, Istanbul, Turkey. Electronic address:

Purpose: The aim of this retrospective study was to investigate the characteristics of cemento-osseous dysplasia (COD) lesions for devising a clinical algorithm to help management decisions, specifically discussing the need for a possible surgical intervention versus solely follow-up.

Materials And Methods: One hundred thirty five subjects were thus identified having previously diagnosed and treated for COD from the archives of the pathology in between 2005-2015. These were then re-evaluated. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.06.002DOI Listing

A Multicenter Study of Tongue Lesions from Thailand.

Eur J Dent 2020 Jun 15. Epub 2020 Jun 15.

Department of Oral Biology and Oral Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Objective: Tongue lesions constitute a considerable proportion of the oral lesions. Previous studies on tongue lesions were based on clinical studies. There has been a scarcity of the studies which are based on histopathological examination. Read More

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http://dx.doi.org/10.1055/s-0040-1713296DOI Listing

Odontogenic sarcoma: First report after new who nomenclature with systematic review.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):157-163. Epub 2020 May 8.

Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Ameloblastic fibrosarcoma (AFS) now designated as odontogenic sarcoma is a malignant odontogenic tumor characteristically composed of a benign epithelium and a malignant mesenchymal component. It can arise without any preexisting lesion or it can result from the malignant transformation of ameloblastic fibroma (AF). Hereby, we report an extremely rare case of odontogenic sarcoma which was transformed from AF over a period of about 2 years. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_14_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269291PMC

Relative frequency of oral focal reactive overgrowths: An institutional retrospective study.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):76-80. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Context: Focal fibrous hyperplasia, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, giant cell fibroma and focal reactive overgrowth (FROGs) are one of the foremost numerous benign soft-tissue growths in the oral cavity. Chronic irritation or trauma is with identified as the causative aspect. It may develop up to few centimeters in diameter, pedunculated or sessile and may arise on the gingiva or buccal mucosa. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_350_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269285PMC

Oral Fibroma Removal With a Er,Cr:YSSG Laser.

Compend Contin Educ Dent 2020 May;41(5):e17-e22

Assistant Professor, Ostrow School of Dentistry, University of Southern California, Los Angeles, California; Private Practice, Santa Monica, California.

Fibromas often occur orally and are typically due to trauma to underlying connective tissue resulting in tissue enlargement. To prevent continuing trauma to the tissue, excision may be recommended, and biopsy is often indicated for these masses to confirm their diagnosis and to rule out a potential malignant cause. This article presents a case report in which a Er,Cr:YSSG laser was utilized for excision of an oral fibroma. Read More

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Familial florid cemento-osseous dysplasia: a report of three cases and review of the literature.

Dentomaxillofac Radiol 2020 Apr 21:20190486. Epub 2020 Apr 21.

Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Familial cases of benign fibro-osseous lesions of the jaws are rare and have been described under numerous terms including familial gigantiform cementoma, multiple cemento-ossifying fibromas, sclerotic cemental masses and familial florid cemento-osseous dysplasia. The synonymous and interchangeable use of these terms to describe distinct entities with overlapping features has resulted in confusion and inaccurate categorisation of these lesions. This study highlights three family members with diffuse fibro-osseous jaw lesions with areas of significant expansion. Read More

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http://dx.doi.org/10.1259/dmfr.20190486DOI Listing

Mandibular Ossifying Fibroma and Multiple Oral Papillomas in a Roe Deer ().

Front Vet Sci 2020 2;7:166. Epub 2020 Apr 2.

Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

An emaciated, adult, free-ranging roe deer () presenting a large mandibular mass, was shot by a game warden in Sissach, Switzerland. The head of the roe deer was submitted to the Center for Fish and Wildlife Health for examination. Grossly, the mass consisted of a 6 × 7 × 4 cm mandibular exophytic growth, associated with loss of incisors teeth. Read More

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http://dx.doi.org/10.3389/fvets.2020.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144577PMC

Massive juvenile ossifying fibroma arising from the middle turbinate.

BMJ Case Rep 2020 Apr 14;13(4). Epub 2020 Apr 14.

1st Department of Otorhinolaryngology - Head & Neck Surgery, University of Athens Medical School, Athens, Greece.

A 19-year-old man presented with a long-standing history of nasal obstruction, which gradually became worse over the past 2 years. Nasal endoscopy revealed a sizeable rounded mass covered by a normal-looking mucosa. Imaging studies showed a mass arising from the left middle turbinate that extended throughout the expanse of the anterior skull base. Read More

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http://dx.doi.org/10.1136/bcr-2020-234432DOI Listing

Effective management of focal reactive gingival overgrowths by diode laser: A review and report of two cases.

Laser Ther 2019 Dec;28(4):291-297

Department of Oral Pathology and Microbiology, Govt. College of Dentistry, Indore, Madhya Pradesh (India) 452001.

Background: Focal reactive gingival overgrowths (FRGO) are a common observation in a clinical dental practice that may occur in response to external and internal chronic stimuli in form of fibrous connective tissue lesions in the oral mucosa. Gingiva is the most commonly involved site of oral reactive lesions. For the confirmed diagnosis of FRGO not only clinical, but the histopathological presentation of the lesion plays a vital role. Read More

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http://dx.doi.org/10.5978/islsm.19-CR-03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087338PMC
December 2019

SATB2 is frequently expressed in ossifying and non-ossifying peripheral oral fibroma of the gingival region but not in reactive fibromatous lesions from other intraoral sites.

Ann Diagn Pathol 2020 Apr 2;46:151510. Epub 2020 Apr 2.

Institute of Pathology, University Hospital, Erlangen, Germany.. Electronic address:

Ossifying and non-ossifying peripheral oral fibromas (POF) of the gingival and alveolar mucosa are localized, cellular, small fibrous nodular lesions likely resulting from diverse external/ internal physical and chemical irritation or injuries. A central nidus of metaplastic woven bone characterizes and defines the ossifying variant. The inherent tendency of these lesions to ossify remains elusive. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151510DOI Listing

Desmoplastic Fibroma of the Jaws: A Case Series and Review of Literature.

Iran J Pathol 2020 26;15(2):134-143. Epub 2020 Jan 26.

Department of Oral and Maxillofacial Radiology, Dentistry School, Kashan University of Medical Sciences, Kashan, Iran.

Desmoplastic fibroma (DF) is a benign, locally aggressive neoplasm that rarely occurs in the facial skeleton. It usually presents during the first three decades of life. Due to its aggressiveness and high recurrence rate, early diagnosis is imperative, and complete surgical removal of the lesion is the treatment of choice. Read More

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http://dx.doi.org/10.30699/ijp.2020.103833.2049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081768PMC
January 2020

Central Odontogenic Fibroma with Giant Cell Granuloma-Like Lesion: A Report of an Additional Case and Review of Literature.

Head Neck Pathol 2020 Mar 24. Epub 2020 Mar 24.

Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Central odontogenic fibroma is a rare benign odontogenic tumor that relies on clinical-radiographic-histological correlation to reach its diagnosis, especially its rare variants. Of these rare types is the coexistence of giant cell granuloma-like lesion, with the characteristic odontogenic epithelial rests. The presented case is a 33 years old female complaining of asymptomatic mandibular bony swelling. Read More

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http://dx.doi.org/10.1007/s12105-020-01153-zDOI Listing

Three types of ossifying fibroma: A report of 4 cases with an analysis of CBCT features.

Imaging Sci Dent 2020 Mar 17;50(1):65-71. Epub 2020 Mar 17.

Department of Oral and Maxillofacial Radiology, College of Dentistry, Chosun University, Gwangju, Korea.

Ossifying fibroma is a slow-growing benign neoplasm that occurs most often in the jaws, especially the mandible. The tumor is composed of bone that develops within fibrous connective tissue. Some ossifying fibromas consist of cementum-like calcifications, while others contain only bony material; however, a mixture of these calcification types is commonly seen in a single lesion. Read More

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http://dx.doi.org/10.5624/isd.2020.50.1.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078407PMC

A large maxillary cemento-ossifying fibroma superimposed with solitary bone cyst documented over 18 years: A case report.

Int J Surg Case Rep 2020 7;68:257-262. Epub 2020 Mar 7.

Centre for Oral and Maxillofacial Surgery, University of Dental Medicine and Oral Health, Danube Private University, Steiner Landstraße 124, 3500 Krems-Stein, Austria. Electronic address:

Introduction: Cemento-ossifying fibromas are rare, benign lesions of the head and neck regions. The origin of these lesions can be traced to the periodontal ligament, because its cells are able to form cement, lamellar bone, or fibrous tissue.

Case Presentation: A rare case report of a young Caucasian female with a COF is described including follow-ups. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082601PMC

Focal cemento-osseous dysplasia: A case report with a review of literature.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S15-S18. Epub 2020 Feb 28.

Department of Oral and Maxillofacial Pathology, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Cemento-osseous dysplasia (COD) is the most prevalent lesion and presents as an asymptomatic, mixed radiolucent/radiopaque lesion in the tooth-bearing region of the jawbones. Histological features of COD include a cellular connective tissue stroma interspersed by the islands of woven or lamellar bone and cementum-like calcifications. Radiographically, the early COD lesions appear radiolucent, whereas in the mature lesions, radiopacities are observed surrounded by a thin rim of radiolucency. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_349_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069140PMC
February 2020

Ameloblastic fibrosarcoma - A rarity?

JPRAS Open 2019 Sep 21;21:56-62. Epub 2019 Jun 21.

Department of Orthodontics, College of Dentistry, Jouf University, Kingdom of Saudi Arabia.

Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour classified by the WHO (1992) as an odontogenic sarcoma and defined as "a neoplasm with a similar structure to ameloblastic fibroma (AF) but in which the ectomesenchymal component shows the features of a sarcoma." The first report of AFS was published by Heath in 1887. AFS and related lesions are less frequently diagnosed than odontogenic carcinomas. Read More

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http://dx.doi.org/10.1016/j.jpra.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061648PMC
September 2019

Staining efficacy assessment of a differential routine and special stains for pathological stromal calcifications in maxillofacial lesions.

J Histotechnol 2020 Mar 10:1-7. Epub 2020 Mar 10.

Department of Oral Pathology and Microbiology, I.T.S Centre for Dental Studies and Research, Ghaziabad, India.

Head and neck connective tissue lesions may have diverse calcifications within the fibrous connective tissue stroma. The perplexity involved in the identification and determination of the nature or degree of calcification through routine hematoxylin and eosin (H&E) stains necessitates the usage of a specific, simple, and cost- and time-effective differential staining techniques. The aim of the present study was to develop criteria to distinguish bone formation from bone resorption using methylene blue-acid fuchsin (MB/AF) stain and the role of collagen fibers in the identification of stromal calcifications using polarizing microscopy with picrosirius red stain. Read More

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http://dx.doi.org/10.1080/01478885.2020.1739192DOI Listing

Unusual exophytic gingival lesion in a newborn treated with diode laser.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Feb 24. Epub 2020 Feb 24.

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Gingival lesions rarely occur in newborns. However, when present, they commonly worry the parents and impair the infant's feeding, thus affecting growth. Such lesions are usually nonneoplastic in nature, although malignancies may develop; therefore, specimens must be submitted for histopathologic examination. Read More

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http://dx.doi.org/10.1016/j.oooo.2020.01.007DOI Listing
February 2020

Comparative Evaluation of SMAD-2 Expression in Oral Submucous Fibrosis and Reactive Oral Lesions.

Asian Pac J Cancer Prev 2020 Feb 1;21(2):399-403. Epub 2020 Feb 1.

Department of Oral Pathology and Microbiology, SRM Dental College, SRM University, Chennai, India.

Background: The event of fibrosis encompasses involvement of definite immunological and molecular mechanisms. As quite a lot of pro-fibrotic pathways are concerned, a multipronged approach is obligatory to cognize the fibrotic events. SMAD signaling pathway hasn't been studied oral fibrotic events. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.2.399DOI Listing
February 2020

Peripheral ameloblastoma of the gingiva.

Autops Case Rep 2020 Jan-Mar;10(1):e2019127. Epub 2019 Dec 13.

Sri Balaji Vidyapeeth University, Indira Gandhi Institute of Dental Sciences, Department of Oral Pathology and oral Microbiology. Puducherry, Puducherry, India.

Peripheral Ameloblastoma (PA) is a benign odontogenic tumor, arising from the cell rest of Serres, reduced enamel epithelium and basal cells of the surface epithelium. Peripheral ameloblastoma is a rare odontogenic neoplasm occurring commonly in the mandibular gingiva. PA clinically resembles other peripherally occurring lesions like pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and squamous papilloma. Read More

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http://dx.doi.org/10.4322/acr.2019.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945308PMC
December 2019

Benign tumours and tumour-like lesions in the oral cavity: a retrospective analysis.

Postepy Dermatol Alergol 2019 Dec 10;36(6):744-751. Epub 2018 Oct 10.

Department of Plastic, Aesthetic and Reconstructive Surgery, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Introduction: Oral lesions are divided into non-neoplastic lesions, potentially malignant lesions and neoplastic lesions. More clinical data are needed to determine their helpful clinical pattern.

Aim: To present the epidemiological, clinical and histopathological characteristics of the oral lesions. Read More

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http://dx.doi.org/10.5114/ada.2018.78805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986298PMC
December 2019

The BRAF p.V600E mutation is a common event in ameloblastomas but is absent in odontogenic keratocysts.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Mar 12;129(3):229-235. Epub 2019 Apr 12.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, PR China. Electronic address:

Objective: Odontogenic keratocysts (OKCs) are jaw lesions with a tendency to recur. PTCH1 gene mutations are common events in most OKCs; however, other genetic alterations underlying OKC pathogenesis have not yet been elucidated. BRAF p. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.04.001DOI Listing

Evaluation of biopsies of oral and maxillofacial lesions: a retrospective study.

J Korean Assoc Oral Maxillofac Surg 2019 Dec 26;45(6):316-323. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.

Objectives: This study aimed to determine the prevalence of odontogenic cysts, tumors, and other lesions among reports in the archives of the Department of Oral and Maxillofacial Surgery at the Faculty of Dentistry affiliated with Kocaeli University collected over a four-year period.

Materials And Methods: In this retrospective study, patient records from the archive of the Department of Oral and Maxillofacial Surgery from 2014 to 2018 were reviewed. Patient demographic information (age and sex) and lesion location were recorded and analyzed. Read More

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http://dx.doi.org/10.5125/jkaoms.2019.45.6.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955426PMC
December 2019

Intraoral Approach for Surgical Treatment of Psammomatoid Juvenile Ossifying Fibroma.

J Craniofac Surg 2020 May/Jun;31(3):e306-e309

Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Pernambuco, Recife.

Psammomatoid juvenile ossifying fibroma (PJOF) is a rare benign tumor that usually affects the paranasal sinuses, orbit, and skull. In most cases, extensive incisions are necessary for full access to the tumor site. The aim of this paper is to report a case of extensive PJOF in which an intraoral surgical approach was performed with complete excision of the tumor. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006171DOI Listing
January 2020

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called "Thanatosomes".

Head Neck Pathol 2020 Jan 8. Epub 2020 Jan 8.

Division of Oral and Maxillofacial Pathology, Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, 515 Delaware Street SE 16-206B, Minneapolis, MN, 55455, USA.

Primary intraosseous xanthomas of the jaws (PIXJ) are rare and predominantly affect the posterior mandible (86%) of normolipemic patients, with a mean age of 30 years and no gender predilection. Clinically, PIXJ exhibit indolent biologic behavior; curettage is considered treatment of choice. Only 36 PIXJ have been reported. Read More

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http://dx.doi.org/10.1007/s12105-020-01126-2DOI Listing
January 2020

A case of desmoplastic fibroma of bone with CTNNB1 point mutation.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Apr 16;129(4):e230-e233. Epub 2019 Sep 16.

Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Oita, Japan.

Desmoplastic fibroma of bone (DFB), a bone tumor, is considered to be an osseous counterpart of desmoid-type fibromatosis (DF). Herein, we report a case of DFB with CTNNB1 point mutation. The 5-year-old male patient had complained of trismus and pain in the jaw. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.09.007DOI Listing

Ameloblastic fibrosarcoma: clinicopathological and molecular analysis of seven cases highlighting frequent BRAF and occasional NRAS mutations.

Histopathology 2020 May 16;76(6):814-821. Epub 2020 Apr 16.

Sarcoma Centre, Western German Cancer Centre, University of Duisburg-Essen Medical School, Essen, Germany.

Aims: Ameloblastic fibrosarcoma (AFS) is an aggressive odontogenic neoplasm featuring malignant mesenchymal stroma in addition to an ameloblastic epithelial component, and is hence considered to be the malignant counterpart of ameloblastic fibroma (AF). AFS is exceedingly rare, with <110 cases having been reported so far. Although BRAF mutations are recognised driver mutations in ameloblastoma, the molecular pathogenesis of AFS remains elusive. Read More

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http://dx.doi.org/10.1111/his.14053DOI Listing

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature.

Head Neck Pathol 2020 Jan 2. Epub 2020 Jan 2.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Read More

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http://dx.doi.org/10.1007/s12105-019-01123-0DOI Listing
January 2020

Comparative Analysis of the Histopathologic Features, β-Catenin, and Ki67 Expression between Fibromatosis and Fibrosarcoma.

J Dent (Shiraz) 2019 Dec;20(4):255-263

Dept. of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Statement Of The Problem: The biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma.

Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these lesions.

Materials And Method: In this cross-sectional descriptive study, 40 specimens comprising 20 fibrosarcoma and 20 fibromatosis biopsies were selected. Read More

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http://dx.doi.org/10.30476/dentjods.2019.44900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890813PMC
December 2019

Clinicopathological study of ameloblastoma and detection of human papilloma virus by immunohistochemistry.

Pak J Med Sci 2019 Nov-Dec;35(6):1691-1696

Dr. Maria Illyas BDs, MPhil. Senior Registrar Oral Pathology, Baqai Medical and Dental College, Karachi, Pakistan.

Objective: To study the clinocopathological factors and presence of Human Pappiloma Virus in ameloblastoma by immnohistochemistry.

Methods: It was a cross sectional study on 50 surgical specimens of ameloblastoma, completed in six months. These were selected and processed for initial screening by H&E and then by immunohistochemistry (IHC) for detection of Human Papilloma Virus (HPV). Read More

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http://dx.doi.org/10.12669/pjms.35.6.909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861475PMC
November 2019

Diagnosis and Treatment of a Benign Pediatric Mandible Tumor.

Plast Reconstr Surg Glob Open 2019 Oct 15;7(10):e2452. Epub 2019 Oct 15.

Department of Surgery, Plastic and Reconstructive Surgery Section, Virginia Tech Carilion School of Medicine, Roanoke, Va.

Pediatric mandible tumors are rare and generally benign but can be locally aggressive. Diagnosis and treatment involve tumor identification, excision, and subsequent reconstruction. Successful reconstruction should address form and function of the mandible while minimizing morbidity. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846312PMC
October 2019

Highly Proliferative Ameloblastic Fibroma: A Rare Entity.

Contemp Clin Dent 2018 Oct-Dec;9(4):656-658

Department of Orthodontics, Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.

Ameloblastic fibroma (AF) is a rare odontogenic neoplasm which is commonly seen in the second decade of life. It is seen most frequently in the mandibular posterior region. AF shows clinical and radiographic resemblance with other commonly occurring odontogenic cyst and tumors. Read More

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http://dx.doi.org/10.4103/ccd.ccd_637_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868614PMC
November 2019

Ossifying Fibroma of Maxilla in a Female Affected by Neurofibromatosis Type 1.

Indian J Otolaryngol Head Neck Surg 2019 Nov 10;71(Suppl 3):2087-2090. Epub 2018 Sep 10.

Department of Oral and Maxillofacial Surgery, Yogita Dental College and Hospital, Naringi Riverside, Dapoli Road, Khed, Ratnagiri, Maharashtra India.

Ossifying fibroma is a benign fibro-osseous lesion found exclusively in jaws. It has a predilection for premolar-molar region in the mandible. The occurrence of OF as solitary lesions with no underlying disease is common in jaws. Read More

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http://dx.doi.org/10.1007/s12070-018-1491-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848415PMC
November 2019

Storiform collagenoma (sclerotic fibroma) of the oral mucosa.

Br J Oral Maxillofac Surg 2020 Feb 21;58(2):231-233. Epub 2019 Nov 21.

University Hospitals Birmingham NHS Foundation Trust. Electronic address:

Storiform collagenoma (also called sclerotic fibroma) is uncommon, occurs as a cutaneous fibrous neoplasm, and is particularly rare in mucosal tissue in the head and neck. We describe an unexpected diagnosis in the oral cavity. Histopathological examination showed a proliferation of fibrous tissue, which was well circumscribed but unencapsulated, with thick laminated bundles of eosinophilic collagen that exhibited a storiform or "whorled" pattern. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.11.005DOI Listing
February 2020

A Rare Case of Ossifying Fibroma with Cystic Degeneration: Diagnostic Challenge with Literature Review.

Indian J Otolaryngol Head Neck Surg 2019 Oct 11;71(Suppl 1):827-830. Epub 2019 Apr 11.

3Department of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Pt. BD Sharma University of Health Sciences, Rohtak, Haryana India.

Cystic degeneration can occur with various bone lesions. These non-epithelial lined cysts vary from aneurysmal bone cyst, solitary bone cyst or non specific cystic degeneration. In jaws, this association is not well documented. Read More

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http://dx.doi.org/10.1007/s12070-019-01656-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848645PMC
October 2019
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Making sense of giant cell lesions of the jaws (GCLJ): lessons learned from next-generation sequencing.

J Pathol 2020 02 18;250(2):126-133. Epub 2019 Dec 18.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Next-generation sequencing has revealed mutations in several bone-related lesions and was recently used to uncover the genetic basis of giant cell lesions of the jaws (GCLJ). Consistent with their benign nature, GCLJ show a low tumor mutation burden. They also harbor somatic, heterozygous, mutually exclusive mutations in TRPV4, KRAS, or FGFR1. Read More

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http://dx.doi.org/10.1002/path.5365DOI Listing
February 2020

Canine and Feline Oral Cavity Tumours and Tumour-like Lesions: a Retrospective Study of 486 Cases (2015-2017).

J Comp Pathol 2019 Oct 18;172:80-87. Epub 2019 Oct 18.

University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Oral cavity tumours and tumour-like lesions are common in dogs and cats, and their diagnosis and classification requires histopathological examination. The aim of this study was to analyse retrospectively oral cavity lesions in dogs and cats in order to evaluate the distribution of inflammatory, hyperplastic and neoplastic lesions manifested as tumours. A total of 486 oral cavity tumours and tumour-like lesions (340 canine; 146 feline), diagnosed routinely from 2015 to 2017, were included. Read More

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http://dx.doi.org/10.1016/j.jcpa.2019.09.007DOI Listing
October 2019
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Histopathological analysis of the differential diagnosis of peripheral odontogenic fibroma from fibrous epulis.

J Oral Biosci 2019 12 25;61(4):221-225. Epub 2019 Oct 25.

Division of Environmental Pathology, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa, 238-8580, Japan.

Objectives: Peripheral odontogenic fibroma (POF) is a relatively rare odontogenic tumor of the gingiva. Although its histological differential diagnosis from fibrous epulis (FE) is important, no study has reported the differences in their expression of immunohistochemical markers. Here, we compared the expression of tumor markers that are frequently used for the differential diagnosis of fibroproliferative lesions between POF and FE. Read More

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http://dx.doi.org/10.1016/j.job.2019.10.003DOI Listing
December 2019

Primordial odontogenic tumor with prominent calcifications: A rare case report.

J Clin Exp Dent 2019 Oct 1;11(10):e952-e956. Epub 2019 Oct 1.

DDS. Lecturer, Mahachakri Sirindhorn Dental Hospital, Faculty of Dentistry, Mahidol University, Nakhon Pathom, Thailand.

Primordial odontogenic tumor (POT) is a rare odontogenic tumor. It is a new entity in the latest edition of the World Health Organization classification in 2017. In the English-language literature, only 14 cases have been documented. Read More

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http://dx.doi.org/10.4317/jced.55925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797464PMC
October 2019

Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma.

F1000Res 2019 30;8:1218. Epub 2019 Jul 30.

Department of Oral and Maxillofacial Pathology, Cairo University, Giza, Egypt.

Central giant cell granuloma (CGCG) is classified by the World Health Organization as a benign bone lesion. It is found anteriorly in the mandible, with most of the cases crossing the midline. In total, 70% of CGCGs are encountered in young females. Read More

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http://dx.doi.org/10.12688/f1000research.19891.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784877PMC

[Desmoplastic fibroma in mandible: a case report].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 10;54(10):696-698

Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116022, China.

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.10.010DOI Listing
October 2019

Clinicopathological features of peripheral ossifying fibroma in a series of 41 patients.

Br J Oral Maxillofac Surg 2019 12 8;57(10):1081-1085. Epub 2019 Oct 8.

Department of Pathology, Clinical University Hospital, Santiago de Compostela, Spain; Department of Pathology and Forensic Sciences, University of Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain. Electronic address:

Peripheral ossifying fibromas are benign mesenchymal lesions that usually arise in the anterior maxilla of young female patients. Histologically they consist of spindle cell proliferation with focal mineralisation. We reviewed 48 specimens from 41 patients and recorded the clinical data, sex, and age of the patients, site and size of the lesions, treatment, and postoperative outcome. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.09.020DOI Listing
December 2019
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Diagnostic considerations in central odontogenic fibroma of the maxilla: 2 case reports.

Imaging Sci Dent 2019 Sep 24;49(3):229-234. Epub 2019 Sep 24.

Department of Oral and Maxillofacial Radiology, Graduate School, Kyung Hee University, Seoul, Korea.

Central odontogenic fibroma (COF) is defined as a fibroblastic odontogenic tumor characterized by varying density of the tooth epithelium. It is an extremely rare benign neoplasm that occurs in the maxilla and the mandible; only a few reports of COF are available in the literature. Diagnosis of the lesion based only on the radiological features of COF is difficult due to variation in the findings regarding this condition. Read More

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http://dx.doi.org/10.5624/isd.2019.49.3.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761066PMC
September 2019

Secondary desmoplastic fibroma-like tissue changes in mandibular fibrous dysplasia: clinicopathological and molecular study of a case.

Br J Oral Maxillofac Surg 2020 01 26;58(1):96-98. Epub 2019 Sep 26.

Department of Molecular Medicine, Sapienza University of Rome, Italy.

Fibrous dysplasia may show locally aggressive behaviour reflecting secondary intralesional changes, extension to soft tissue, or malignant transformation. We report the case of a patient with polyostotic fibrous dysplasia who had a giant mandibular lesion consisting of histologically typical, genotypically-confirmed, fibrous dysplasia merged with a fibrotic and hypocellular desmoplastic fibroma-like tissue in which the same Gsα-R201H mutation was detected. The occurrence of the same mutation in both the fibrous dysplasia and areas of desmoplastic fibroma suggests that the fibroma-like tissue reflects an unusual secondary tissue change within an otherwise typical fibrous dysplasia. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.09.006DOI Listing
January 2020
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Comparison of Hematoxylin and Eosin Stain with Modified Gallego's Stain for Differentiating Mineralized Components in Ossifying Fibroma, Cemento-ossifying Fibroma, and Cementifying Fibroma.

J Microsc Ultrastruct 2019 Jul-Sep;7(3):124-129

Department of Oral and Maxillofacial Pathology and Microbiology, D Y Patil Deemed to be University School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.

Objective: The nature of calcifications in fibro-osseous lesions is difficult to differentiate under hematoxylin and eosin (H and E) stain and could be misleading. Special stains could be used. Modified Gallego's stain is a differential stain for hard tissues, which has been discussed recently in the literature. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_2_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753700PMC
September 2019
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Atypical Presentation of Giant Mandibular Aneurysmal Bone Cyst with Cemento-Ossifying Fibroma Mimicking Sarcoma.

Case Rep Otolaryngol 2019 27;2019:1493702. Epub 2019 Aug 27.

Department of Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Aneurysmal bone cysts (ABCs) are an uncommon osteolytic intraosseous bone lesions. ABCs commonly involve metaphysis of long bones and are rarely diagnosed in craniofacial bones. The World Health Organization (WHO) designates ABCs as benign, but locally destructive, rapidly growing masses. Read More

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http://dx.doi.org/10.1155/2019/1493702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732594PMC
August 2019
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Giant Peripheral Ossifying Fibroma Treated With Piezosurgery and Platelet-Rich Fibrin: A Rare Case Report.

Clin Adv Periodontics 2019 03 28;9(1):15-19. Epub 2018 Sep 28.

Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Alfenas, MG, Brazil.

Introduction: The peripheral ossifying fibroma (POF) is a benign reactive lesion that exclusively arises from gingiva. The lesion may gain considerably large sizes and present peculiar clinical and radiographic features that would then allow it to be called a giant POF; in that case, its otherwise simple surgical extraction could create a challenge. Thus, we elect here, for the very first time, a plausible alternative for treating giant POF: piezosurgery followed by placement of platelet-rich fibrin (PRF). Read More

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http://dx.doi.org/10.1002/cap.10042DOI Listing
March 2019
3 Reads