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    Extragenital Chlamydia and Gonorrhea in Young Black Men Who Have Sex With Men: Missed Treatment Opportunities for HIV-Infected MSM?
    Sex Transm Dis 2017 Oct 19. Epub 2017 Oct 19.
    University of Mississippi Medical Center.
    Objectives: This study of young Black MSM (YBMSM) assessed the prevalence of extra-genital chlamydia and gonorrhea among those testing negative for urethral infections, and compared prevalence of both by HIV status.

    Methods: A convenience sample of 609 YBMSM was recruited for a cross-sectional study from two sexual health clinics located in Jackson, MS. To detect C. Read More

    The Etiology of Vaginal Discharge Syndrome in Zimbabwe Results from the Zimbabwe STI Etiology Study.
    Sex Transm Dis 2017 Nov 29. Epub 2017 Nov 29.
    Surveillance, Evaluation, Assessment and Monitoring (SEAM), Project, Department of Community Medicine, University of Zimbabwe, College of Health Sciences.
    Introduction: Symptomatic vaginal discharge is a common gynecological condition managed syndromically in most developing countries. In Zimbabwe, women presenting with symptomatic vaginal discharge are treated with empirical regimens that commonly cover both sexually transmitted infections (STI) and reproductive tract infections, typically including a combination of an intramuscular injection of kanamycin, and oral doxycycline and metronidazole regimens. This study was conducted to determine the current etiology of symptomatic vaginal discharge and assess adequacy of current syndromic management guidelines. Read More

    Augmented reality in dentistry: a current perspective.
    Acta Odontol Scand 2018 Feb 21:1-7. Epub 2018 Feb 21.
    a Department of Prosthodontics, School of Dentistry , Seoul National University and Dental Research Institute , Seoul , Korea.
    Augmentation reality technology offers virtual information in addition to that of the real environment and thus opens new possibilities in various fields. The medical applications of augmentation reality are generally concentrated on surgery types, including neurosurgery, laparoscopic surgery and plastic surgery. Augmentation reality technology is also widely used in medical education and training. Read More

    [Diagnostic value of optical coherence tomography for oral leukoplakia assessment].
    Stomatologiia (Mosk) 2018 ;97(1):37-39
    Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
    The article presents a comparative analysis of the results of in vivo scanning of oral mucosa leukoplakia with optical coherence tomography (OCT) method and pathological studies in 15 patients (9 females and 6 males aged 27-82). The study revealed specific OCT signs of leukoplakia: even disorder of tissue layering and less clear visualization of lamina propria. OCT is an important stage in the differential diagnosis of leukoplakia of the oral mucosa and significantly complements the clinical and pathomorphological study. Read More

    Surgical Management of a Bilateral Bifid Condyle: Diagnosis, Three-dimensional Reconstruction, and Treatment - A Report of a Case and Review of the Literature.
    Niger J Clin Pract 2018 Feb;21(2):251-255
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
    Bifid condyle is a rare entity with a difficult diagnosis and usually identified as an incidental finding on routine radiographic examination. The etiology is not well known, possible causes may be developmental, traumatic, vascular, abnormal muscle pulling, nutritional, endocrinal, teratogenic, and infections. The orientation of the condylar heads can behelpful for the etiological diagnosis. Read More

    Factitious hypoglycemia in children and adolescents with diabetes.
    Pediatr Diabetes 2018 Feb 21. Epub 2018 Feb 21.
    Section of Pediatric Diabetes and Metabolism, DEOB, NIDDK, NIH, Bethesda, Maryland.
    Background: Factitious hypoglycemia is a condition of self-induced hypoglycemia due to surreptitious administration of insulin or oral hypoglycemic agents. In adults, it is an uncommon, but well known clinical entity observed in individuals with and without diabetes.

    Objectives: To report a case of factitious hypoglycemia highlighting diagnostic pitfalls, to identify common characteristics of children and adolescents with factitious hypoglycemia, and to examine whether the information on long-term outcome exists. Read More

    Is oral feeding compatible with an unresponsive wakefulness syndrome?
    J Neurol 2018 Feb 20. Epub 2018 Feb 20.
    GIGA Consciousness, Coma Science Group and Neurology Department, University and University Hospital of Liege, Liège, Belgium.
    Objective: The aim of the study is to explore the possibility of oral feeding in unresponsive wakefulness syndrome/vegetative state (UWS/VS) patients.

    Method: We reviewed the clinical information of 68 UWS/VS patients (mean age 45 ± 11; range 16-79 years) searching for mention of oral feeding. UWS/VS diagnosis was made after repeated behavioural assessments using the Coma Recovery Scale-Revised. Read More

    Long-term effects of Class II orthodontic treatment on oral health.
    J Orofac Orthop 2018 Feb 20. Epub 2018 Feb 20.
    Department of Orthodontics, University of Giessen, Schlangenzahl 14, 35392, Giessen, Germany.
    Aim: To investigate the long-term (≥15 years) benefit of orthodontic Class II treatment (Tx) on oral health (OH).

    Subjects And Methods: All patients (Department of Orthodontics, University of Giessen, Giessen, Germany) who underwent Class II correction (Herbst-multibracket Tx, end of active Tx ≥ 15 years ago) and agreed to participate in a recall (clinical examination, interview, impressions, and photographs) were included. Records after active Tx were used to assess the long-term OH effects. Read More

    Temporomandibular Joint Septic Arthritis.
    Plast Reconstr Surg Glob Open 2018 Jan 23;6(1):e1648. Epub 2018 Jan 23.
    Division of Pediatric Plastic Surgery, SSM Health Cardinal Glennon Children's Hospital at Saint Louis University School of Medicine, St. Louis, Mo.; Department of Radiology, Neuroradiology Section, Saint Louis University School of Medicine, St. Louis, Mo.; and SSM Health Cardinal Glennon Children's Hospital at Saint Louis University School of Medicine, St. Louis, Mo.
    Infection of the temporomandibular joint (TMJ) is a rare pediatric condition resulting from the introduction of pathogens into the joint by hematogenous seeding, local extension, or trauma. Early recognition of the typical signs and symptoms including fever, trismus, preauricular swelling, and TMJ region tenderness are critical in order to initiate further evaluation and prevent feared complications of fibrosis, ankylosis, abnormal facial structure, or persistence of symptoms. Contrast-enhanced computed tomography with ancillary laboratory analysis including erythrocyte sedimentation rate, C-reactive protein, and white blood cell count are beneficial in confirming the suspected diagnosis and monitoring response to therapy. Read More

    The opioid epidemic in acute care surgery-characteristics of overprescribing following laparoscopic cholecystectomy.
    J Trauma Acute Care Surg 2018 Feb 17. Epub 2018 Feb 17.
    Author Affiliations: Department of Surgery (Thiels, Polites, Ray-Zack, Zielinski), Surgical Outcomes Program, The Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery (Hanson, Habermann), Department of Anesthesiology (Gazelka), Mayo Clinic, Rochester MN.
    Background: Postoperative prescribing following acute care surgery must be optimized to limit excess opioids in circulation as misuse and diversion are frequently preceded by a prescription for acute pain. This study aimed to identify patient characteristics associated with higher opioid prescribing following laparoscopic cholecystectomy (LC).

    Methods: Among patients age ≥18 years who underwent LC at a single institution 2014-2016, opioids prescribed at discharge were converted to oral morphine equivalents (OME) and compared to developing state guidelines (max 200 OME). Read More

    Development of (6R)-2-nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (DNDI-8219): a new lead for visceral leishmaniasis.
    J Med Chem 2018 Feb 20. Epub 2018 Feb 20.
    Discovery of the potent antileishmanial effects of antitubercular 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles and 7-substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines stimulated the examination of further scaffolds (e.g., 2-nitro-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]oxazepines) but the results for these seemed less attractive. Read More

    Identification of SCARA5 as a potential biomarker for oral squamous cell carcinoma using MALDI TOF MS analysis.
    Proteomics Clin Appl 2018 Feb 20. Epub 2018 Feb 20.
    Department of Oral & Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Purpose: To find the potential biomarkers in in the diagnostic model of oral and squamous cell carcinoma (OSCC), and to further validate the biomarker.

    Experimental Design: With the MALDI-TOF-MS analysis between tissues from oral cancer patients and normal oral mucosa from healthy controls, scara5 was found to be potentially significant after searching the protein database. In addition, Immunohistochemical staining, PCR, ELISA and western blot technique were used to detect scara5 expression in clinical samples and cell lines. Read More

    Primary neoplasms of the small bowel at CT: a pictorial essay for the clinician.
    Eur Rev Med Pharmacol Sci 2018 Feb;22(3):598-608
    Department of Bio-Imaging and Radiological Sciences, Radiology Institute, Catholic University of the Sacred Heart, Gemelli Foundation, School of Medicine, Rome, Italy.
    Objective: Primary small intestinal neoplasms are uncommon tumors that are often small and difficult to identify. The aim of this paper is to describe CT technique and features in detecting and characterizing the tumors of the small bowel.

    Materials And Methods: This paper focuses on radiological characteristics of benign and malignant primary neoplasms of the small bowel at CT, with special reference to multidetector-CT techniques, type and modality of administration of contrast agents (by oral route or CT-enterography and by nasojejunal tube or CT-enteroclysis). Read More

    The Effect of Unfocused Extracorporeal Shock Wave Therapy on Bone Defect Healing in Diabetics.
    J Craniofac Surg 2018 Feb 14. Epub 2018 Feb 14.
    Department of Radiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
    Aim: The purpose of this study was to evaluate the effect of the unfocused extracorporeal shock wave therapy (ESWT) on healing of mandible ramus defects in diabetic rats.

    Material And Method: Forty male Wistar albino rats were used in the experiment. All animals were randomly divided into 2 main groups, nondiabetic and diabetic. Read More

    Oral health and later coronary heart disease: Cohort study of one million people.
    Eur J Prev Cardiol 2018 Jan 1:2047487318759112. Epub 2018 Jan 1.
    2 Department of Epidemiology and Health Promotion, Yonsei University, South Korea.
    Aims Systematic reviews report an association between poorer oral health and an increased risk of coronary heart disease. This contentious relationship may not be causal but existing studies have been insufficiently well powered comprehensively to examine the role of confounding, particularly by cigarette smoking. Accordingly, we sought to examine the role of smoking in generating the relationship between oral health and coronary heart disease in life-long non-smokers. Read More

    [The proliferative activity of tumor cells and the distribution of SOX2+ pluripotent stem cells in various histological types of ameloblastoma].
    Arkh Patol 2018 ;80(1):21-26
    Department of Dental Surgery, Central Research Institute of Dentistry and Oral Surgery, Ministry of Health of Russia, Moscow, Russia.
    Aim: to investigate the proliferative activity and distribution of pluripotent stem cells in various histological types of amelobrastoma.

    Material And Methods: The surgical and archival materials of 76 patients with ameloblastoma from the Central Research Institute of Dentistry and Oral Surgery, Ministry of Health of the Russian Federation, were used. Tissue antigens were determined using a rabbit monoclonal antibody against to Ki-67 and SOX2. Read More

    Zinc plus octenidine: a new formulation for treating periodontal pathogens. A single blind study.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):231-236
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
    Periodontal treatment has the aim to reduce oral infection, and prevent the progression of the disease. The potential benefits of new chemical devices for periodontal therapy, include improved patient compliance, an easier access to periodontal pocket and a lower dosage of antimicrobial agent. The objective of this study was to explore the efficacy of a chemical device containing zinc and octenidine in the treatment of chronic periodontitis in adult patients. Read More

    Psychiatric disorders in oral lichen planus: a preliminary case control study.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):97-100
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    The aim of this study was to evaluate the prevalence of psychiatric symptoms in patients with oral lichen planus (OLP) compared to a control group. Eleven patients (mean age 65.2 years-old), with diagnosis of OLP and 13 controls (mean age 64. Read More

    Prevalence of HIV-related oral manifestations and their association with HAART and CD4+ T cell count: a review.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):51-59
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
    HIV infection is one of the major health problem of the last decades. This disease causes a chronic infection that can lead to acquired immunodeficiency syndrome (AIDS). According to the Global AIDS update, released in 2016 by HIV department of World Health Organization (WHO) and by the Joint United Nations Program on HIV/AIDS (UNAIDS), at the end of 2015, 36. Read More

    An algorithm for predicting Robin sequence from fetal MRI.
    Prenat Diagn 2018 Feb 19. Epub 2018 Feb 19.
    Associate Professor of Radiology, Harvard Medical School, Boston, MA.
    Background: Infants with Robin sequence (RS) may present with airway compromise at delivery. Prenatal diagnosis would improve preparation and postnatal care. The purpose of this study was to devise a predictive algorithm for RS based on fetal magnetic resonance imaging (MRI). Read More

    Periodontal education and assessment in the undergraduate dental curriculum-A questionnaire-based survey in European countries.
    Eur J Dent Educ 2018 Feb 20. Epub 2018 Feb 20.
    Department of Periodontology, Istanbul University, Istanbul, Turkey.
    Objectives: This survey aimed to evaluate whether periodontal education and assessment in undergraduate dental curricula amongst the member countries of the European Federation of Periodontology (EFP) follow the competency-based curricular guidelines and recommendations developed by the Association for Dental Education in Europe.

    Materials And Methods: A multiple-choice questionnaire was emailed to 244 dental institutes amongst the 24 EFP member countries between November 2014 and July 2015.

    Results: Data were received from 16 (66. Read More

    Continuing rise of Type 2 diabetes incidence in children and young people in the UK.
    Diabet Med 2018 Feb 20. Epub 2018 Feb 20.
    NIHR Biomedical Research Centre: Nutrition, Diet and Lifestyle Theme, School of Oral and Dental Sciences.
    Aims: To estimate the incidence of Type 2 diabetes in children aged <17 years, compare this with similar data 10 years ago, and characterize clinical features at diagnosis in the UK and Republic of Ireland.

    Methods: Using the British Paediatric Surveillance Unit reporting framework, cases of Type 2 diabetes diagnosed in children aged <17 years between 1 April 2015 and 30 April 2016 were reported each month.

    Results: A total of 106 cases were reported, giving a UK incidence of 0. Read More

    Determining Caries Activity Using Oratest Among 12-to 15-year-old Children.
    Oral Health Prev Dent 2018 ;16(1):93-96
    Purpose: Dental caries is the primary pathological cause of early tooth loss in children, which may lead to malnutrition and other health problems. Identification of patients with active carious lesions and at high risk for caries can help to dramatically decrease the disease prevalence. Thus, recognising the importance of early diagnosis of caries, the present study was carried out to correlate caries with oral microflora using Oratest among 12- to 15-year-old schoolchildren. Read More

    Impact of Chronic Kidney Disease Mineral and Bone Disorder on Jaw and Alveolar Bone Metabolism: A Narrative Review.
    Oral Health Prev Dent 2018 ;16(1):79-85
    Chronic kidney disease (CKD) has become a worldwide public health problem. It is estimated that nearly 90% of patients with chronic renal failure manifest some symptoms of oral disease. With advances in medical treatment, CKD patients are living longer and require oral care. Read More

    Non-convulsive Status Epilepticus in Children: Clinical Profile, EEG Characteristics and Treatment.
    Mymensingh Med J 2018 Jan;27(1):185-192
    Dr Kanij Fatema, Associate Professor, Department of Pediatric Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
    Non-convulsive status epilepticus (NCSE) is a term used to denote a range of conditions in which electrographic seizure activity is prolonged and results in non-convulsive clinical symptoms. This study was done to describe the clinical spectrum, EEG findings and to evaluate the efficacy of different therapeutic agents in children with NCSE in 33 patients from January 2011 to December 2015 period. All patients had EEG before and after treatment. Read More

    Arerugi 2018 ;67(1):37-45
    Department of Allergy Aichi Children's Health and Medical Center.
    Background: This study aimed to evaluate the clinical accuracy of specific IgE (sIgE) to Ara h 2 in the diagnosis of peanut allergy (PA). We also investigated the prevalence of complications with other nut allergies in PA patients.

    Methods: The Ara h 2-sIgE titer was examined in patients with positive results for sIgE to peanut from April 2014 to March 2015. Read More

    The Accuracy of Colorectal Cancer Detection by Computed Tomography in the Unprepared Large Bowel in a Community-Based Hospital.
    Can Assoc Radiol J 2018 Feb;69(1):92-96
    Department of Radiology, Lions Gate Hospital, North Vancouver, British Columbia, Canada.
    Purpose: This retrospective study examined the performance of general radiologists in a community-based hospital in detecting colorectal cancer (CRC) with computed tomography (CT) in the unprepared large bowel.

    Methods: The pathology database at a community hospital over the past 7 years (2009-2015) was retrospectively analysed for pathologically proven CRC (924 cases). The provincial hospital information profile for these patients was reviewed to determine if they had an abdominal CT for any reason in the year prior to biopsy. Read More

    Invasive Cutaneous Facial Mucormycosis in a Trauma Patient.
    J Oral Maxillofac Surg 2018 Feb 16. Epub 2018 Feb 16.
    Professor, Oral and Maxillofacial Surgery, University of Texas at Houston, Houston, TX.
    Mucormycosis, also known as zygomycosis, is an aggressive infection caused by a ubiquitous group of molds known as mucormycetes and is often associated with immune suppression or trauma among immunocompetent populations. We present the case of a 19-year-old woman who was involved in a motor vehicle accident in whom rapidly progressive invasive cutaneous facial mucormycosis subsequently developed. The diagnosis, treatment options, and incidence of this disease process are discussed in the context of trauma. Read More

    Early placement of dental implants in maxillary sinus grafted with leukocyte and platelet-rich fibrin (L-PRF) and deproteinized bovine bone mineral.
    J Oral Implantol 2018 Feb 19. Epub 2018 Feb 19.
    6 Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University - UNESP. Araraquara, SP, Brazil.
    This case report aimed to describe the effects of leukocyte and platelet-rich fibrin (L-PRF) associated with deproteinized bovine bone mineral (DBBM) and absorbable collagen membrane (CM) on bone regeneration in maxillary sinus augmentation. A 59-year-old male patient was referred to the Department of Periodontology for implant rehabilitation of his edentulous upper jaw. The treatment plan involved maxillary sinus augmentation followed by implants installation. Read More

    A high prevalence of TMD is related to somatic awareness and pain intensity among healthy dental students.
    Acta Odontol Scand 2018 Feb 18:1-7. Epub 2018 Feb 18.
    b Centre for Musculoskeletal Research, Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies , University of Gävle , Gävle , Sweden.
    Objective: Dental students have been identified as a group with high risks of developing both temporomandibular disorders (TMD) and psychosocial conditions. Our primary aim was to evaluate the cross-sectional prevalence of TMD diagnoses, as defined in the Diagnostic Criteria (DC)/TMD, among dental students. The secondary aim was to evaluate the prevalence and association of behavioural and psychosocial factors in relation to DC/TMD diagnoses. Read More

    Evidence for Alternate Modes of B cell Activation Involving Fab Acquired-N-Glycosylations in Antibody Secreting Cells Infiltrating the Labial Salivary Glands of Sjögren's Syndrome Patients.
    Arthritis Rheumatol 2018 Feb 18. Epub 2018 Feb 18.
    University of Oklahoma Health Sciences Center, Oklahoma City, OK.
    Objective: To better understand the role of B cells, potential mechanisms for their aberrant activation, and the production of autoantibodies in the pathogenesis of Sjögren's Syndrome (SS), we explored selection pressures and N-glycosylation acquired by somatic mutation (acN-glyc) in the immunoglobulin (Ig) variable regions (V-regions) of antibody secreting cells (ASCs) isolated from the minor salivary glands of SS patients and non-SS controls with sicca symptoms.

    Methods: We report a novel method to produce and characterize recombinant monoclonal antibodies (mAbs) from SS patient and control labial salivary gland single-cell sorted ASC infiltrates that can be utilized to concurrently probe any other expressed genes. V-regions were amplified by RT-PCR, sequenced, and analyzed for incidence of N-glycosylation and selection pressure, then expressed as the native mAbs, or mutant mAbs lacking the acN-glyc for specificity testing. Read More

    Influence of orthodontic appliance-derived artifacts on 3-T MRI movies.
    Prog Orthod 2018 Feb 19;19(1). Epub 2018 Feb 19.
    Department of Orthodontic Science, Tokyo Medical and Dental University (TMDU) Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
    Background: Magnetic resonance imaging (MRI) has been used to study configurations of speech organs in the resting state. However, MRI is sensitive to metals, and numerous types of metallic appliances, most of which have a large magnetic susceptibility, are used in orthodontic treatment and may cause severe artifacts on MRI. We have developed techniques for obtaining MRI movies of the oral region, to evaluate articulatory changes, especially movement of the tongue, palate, and teeth, pre- and post-orthodontic/orthognathic treatment. Read More

    Anesthetic management during a cesarean section in a patient with cleidocranial dysplasia: a case report.
    JA Clin Rep 2018 5;4(1). Epub 2018 Jan 5.
    Department of Anesthesiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011 Japan.
    Background: Cleidocranial dysplasia is a type of skeletal dysplasia, which is primarily characterized by delayed ossification of skeletal structures. It causes facial and oral abnormalities, resulting in difficult airway management and neuraxial anesthesia.

    Case Presentation: The patient was a 24-year-old primipara (height 138 cm, weight 42 kg) with a hypoplastic right clavicle, patent fontanelles, dental malalignment, and a high palate. Read More

    A 12-Month-Old Healthy Girl with a New Oral Ulcer and Chronic Diaper Rash.
    Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):24-30. Epub 2017 Nov 16.
    Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
    A 12-month-old healthy girl presented with a chronic diaper rash. Physical examination demonstrated crusting of the scalp, erythematous papules with surrounding petechiae on the lower abdomen, and an intraoral palatal ulcer. Further imaging demonstrated bone involvement. Read More

    Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report.
    Open Dent J 2018 29;12:19-23. Epub 2018 Jan 29.
    Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, SP. Brazil.
    Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman.

    Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. Read More

    A Case of Schwannoma of the Submandibular Region.
    Open Dent J 2018 29;12:12-18. Epub 2018 Jan 29.
    Department of Oral and Maxillofacial Radiology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Background: We herein described a rare case of schwannoma of the hypoglossal nerve in the submandibular region with diagnostic imaging and histopathological findings.

    Case Report: A 31-years-old woman has had a palpable firm, rubbery, freely mobile mass in the submandibular region. Of imaging, MR images showed homogeneous isointensity on T1-weighted imaging (T1-WI), heterogeneous hypointensity on T2-WI, heterogeneous hyperintensity on short T1 inversion recovery (STIR), and heterogeneous enhancement on contrast-enhanced T1-WI. Read More

    Osteonecrosis of the jaw (ONJ) in patients who receive Bone Targeting Agents (BTAs): the power of e-learning.
    Ecancermedicalscience 2018 23;12:ed77. Epub 2018 Jan 23.
    Department of Oral and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610-0412, USA.
    The definition, pathobiology and risk factors of ONJ in cancer patients who receive BTAs are discussed in the recent ecancer module for osteonecrosis of the jaw ( Read More

    An unusual presentation of adult T-cell leukemia/lymphoma.
    Ecancermedicalscience 2018 23;12:801. Epub 2018 Jan 23.
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1-7-1 Sakamoto, 8528501 Nagasaki-shi, Nagasaki, Japan.
    Adult T-cell Leukemia/Lymphoma (ATL) is a rare disease, related to human T-lymphotropic virus-1 (HTLV-1) and presented mainly in adulthood by generalised lymphadenopathy, hepatosplenomegaly, skin lesions and hypercalcaemia, with rare gastrointestinal and/or oral manifestations. We reported this case to raise awareness and demonstrate the therapeutic challenges of this rare disease. A 49-year-old Japanese female presented with skin papules on both forearms, painful mouth ulcers and multiple neck swellings since early February 2017. Read More

    Management of fenestration using bone allograft in conjunction with platelet-rich fibrin.
    J Indian Soc Periodontol 2017 Jul-Aug;21(4):337-340
    Department of Oral surgery, JMF'S A.C.P.M. Dental Collage and Hospital, Dhule, Maharashtra, India.
    Fenestration and dehiscence are said to be anatomical variations of cortical bone and not true pathological entities. They represent window-like defects covered by periosteum and overlying gingiva with or without the intact marginal bone. The etiology of such defects is still unclear, though many hypotheses such as occlusal traumatism, trauma, and variation in root bone angulation have been put forward. Read More

    Reactive lesions of oral cavity: A retrospective study of 659 cases.
    J Indian Soc Periodontol 2017 Jul-Aug;21(4):258-263
    Department of Oral and Maxillofacial Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.
    Objective: This study reviews, analyzes, and compares the demographic data, histopathological features and discusses the treatment and prognosis of reactive lesions (RLs).

    Materials And Methods: Retrospective study was performed on the departmental archives from July 2006 to July 2016 (total 5000 cases) comprising of 659 cases of RLs of the oral cavity. The recorded data included age, gender, size, site, duration, habits, etiology, histopathological diagnosis, treatment, and prognosis. Read More

    Diagnostic value of ultrasonography for the detection of disc displacements in the temporomandibular joint: a systematic review and meta-analysis.
    Clin Oral Investig 2018 Feb 17. Epub 2018 Feb 17.
    Department of Social Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, 1081 LA, Amsterdam, The Netherlands.
    Objectives: The aim was to assess the added diagnostic value of ultrasonography (US) for establishing the presence or absence of disc displacements (DDs) in temporomandibular joints (TMJs).

    Materials And Methods: Pubmed and EMBASE were searched electronically to identify diagnostic accuracy studies that assessed the diagnostic value of US for the diagnosis of DD, using Magnetic resonance imaging (MRI) as the reference standard. Meta-analyses were performed with Metadisc 1. Read More

    Dentinal tubule sealing effects of 532-nm diode-pumped solid-state laser, gallic acid/Fecomplex, and three commercial dentin desensitizers.
    Lasers Med Sci 2018 Feb 17. Epub 2018 Feb 17.
    Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, Seoul National University School of Dentistry, 25-9 Jongro-Gu Yungeon-Dong, Seoul, Republic of Korea.
    The purpose of this study was to compare dentinal tubule sealing effects of a 532-nm diode-pumped solid-state (DPSS) laser, gallic acid/Fecomplex, and three commercially available dentin desensitizers. Human premolars (n = 44) extracted for orthodontics had standardized cervical cavities prepared, etched (37% phosphoric acid) and randomly assigned to either a control (n = 4), or one of five treatment groups (n = 8/group). Desensitizing treatments were either a 532-nm DPSS laser, gallic acid/Fecomplex, oxalate-based Super Seal™ (SS), DIO™ Enamel Coating Pen Pro Tooth (Dio), or adhesive-type Hybrid Coat™ (HC). Read More

    A child with tubulointerstitial nephritis and uveitis (TINU) syndrome.
    BMJ Case Rep 2018 Feb 17;2018. Epub 2018 Feb 17.
    Unidade de Nefrologia e Transplantação Renal Pediátrica, Departamento de Pediatria, Hospital de Santa Maria - Centro Hospitalar de Lisboa Norte, Lisboa, Portugal.
    Tubulointerstitial nephritis and uveitis syndrome is an uncommon disease, probably underdiagnosed in clinical practice. Its aetiology and pathogenesis remain unknown. This syndrome is defined by an association of uveitis and tubulointerstitial nephritis, with no evidence of systemic disease or infection that might cause both ocular and renal inflammation. Read More

    Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells.
    Biochem Biophys Res Commun 2018 Feb 15. Epub 2018 Feb 15.
    Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; Center for Oral Functional Diagnosis, Treatment and Research, Peking University School and Hospital of Stomatology, China. Electronic address:
    Purinergic signaling regulates various biological processes through the activation of adenosine receptors (ARs) and P2 receptors. ATP induces the odontoblastic differentiation of human dental pulp cells (HDPCs) via P2 receptors. However, there is no information available about the roles of ARs in HDPC odontoblastic differentiation induced by ATP. Read More

    Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula.
    J Ethnopharmacol 2018 Feb 15. Epub 2018 Feb 15.
    Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China. Electronic address:
    Ethnopharmacology Relevance: Bufei Yishen formula (BYF), a Traditional Chinese Medicine (TCM), has been extensively applied in clinical treatment of chronic obstructive pulmonary disease (COPD) and provides an effective treatment strategy for the syndrome of lung-kidney qi deficiency in COPD patients. Here, we investigated its anti-COPD mechanism in COPD rats in relation to the balance between T helper (Th) 17 cells and regulatory T (Treg) cells.

    Methods: Rat model of cigarette smoke- and bacterial infection-induced COPD was established, and orally treated with BYF for 12 consecutive weeks. Read More

    Basal cell nevus syndrome (Gorlin syndrome): genetic insights, diagnostic challenges, and unmet milestones.
    Pathophysiology 2018 Jan 31. Epub 2018 Jan 31.
    Department of Oral and Maxillofacial/Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, United States; Chancellor and Dean, Louisiana State University Health Sciences Center, Shreveport, LA, United States.
    In this article, we present three clinical case reports on Basal Cell Nevus Syndrome (Gorlin Syndrome). Gorlin syndrome is an inherited medical condition with challenges that manifest in multiple body systems and complicate early diagnosis. We examine the epidemiology of the disease and benefits of genetic testing, molecular pathophysiology, and advancement in the molecular-based therapy of Basal Cell Nevus syndrome. Read More

    Prognostic importance of FGF2 And FGFR1 expression for patients affected by ameloblastoma.
    J Oral Pathol Med 2018 Feb 17. Epub 2018 Feb 17.
    Oral Medicine Department, Sírio-Libanês Hospital São Paulo/Brazil.
    Background: Fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) have been investigated in different human neoplasms and were shown to play important roles in the pathogenesis of these diseases; however, very few is known regarding their prognostic importance in the context of ameloblastoma. Therefore, the aim of this study is to investigate if the expression of FGF2 and FGFR1 is associated with ameloblastoma clinical behavior.

    Methods: Fifty-eight cases of ameloblastoma arranged in tissue microarray were submitted to immunohistochemistry against FGF2 and FGFR1. Read More

    Cytotoxic effect of chlorpyrifos is associated with activation of Nrf-2/HO-1 system and inflammatory response in tongue of male Wistar rats.
    Environ Sci Pollut Res Int 2018 Feb 16. Epub 2018 Feb 16.
    Department of Oral Biology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
    Repeated administration of chlorpyrifos (CPF), an organophosphate pesticide, can increase the risk of oral cytotoxicity. The current study was designed to assess the mechanism by which CPF mediates its cytotoxic effect on lingual mucosa of rats. Twenty-four male Wistar rats were used in the present study and divided into three groups: group I: healthy rats (negative control), group II: rats treated with CPF 1/40 LD50 (3. Read More

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