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    [Food-dependent exercise-induced anaphylaxis : a stepwise diagnosis].
    Rev Med Suisse 2017 Apr;13(557):734-738
    Service d'immunologie et allergie, CHUV, 1011 Lausanne.
    Food-dependent exercise-induced anaphylaxis (FDEIA) is a potentially severe food allergy. Physical exercise, NSAID, alcohol, infectious diseases and estrogens are recognized cofactors, able to reduce the amount of allergen needed to achieve a threshold for the induction of anaphylaxis. Various kinds of causative food but only a few responsible proteins have been identified. Read More

    Molar incisor hypomineralisation (MIH) training manual for clinical field surveys and practice.
    Eur Arch Paediatr Dent 2017 Jul 18. Epub 2017 Jul 18.
    Oral Health CRC, Melbourne Dental School, The University of Melbourne, Parkville, Melbourne, Australia.
    Background: Despite clear assessment criteria, studies of molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) are marked by inconsistency in outcome measurements. This has detracted from meaningful comparisons between studies and limited interpretation.

    Aim: To provide a comprehensive manual as a companion to assist researchers in planning epidemiological studies of MIH and HSPM, with particular reference to outcome measurement. Read More

    Rhamnolipids Enhance in Vivo Oral Bioavailability of Poorly Absorbed Molecules.
    Pharm Res 2017 Jul 18. Epub 2017 Jul 18.
    College of Engineering, Department of Biomedical Engineering, Cellular Engineering & Nano-Therapeutics Laboratory, University of Michigan, Ann Arbor, Michigan, 48109, USA.
    Purpose: This report describes the effect of rhamnolipids (RLs) on the tight junctions (TJ) of the intestinal epithelium using the rat in-situ closed loop model.

    Methods: We investigated the transport of 5 (6)-carboxyfluorescein (CF) and fluorescein isothiocyanate-labeled dextrans with average molecular weights of 4.4 and 10 kDa (FD-4 and FD-10) when co-administered with different concentrations of RLs. Read More

    Pasireotide: successful treatment of a sparsely granulated tumour in a resistant case of acromegaly.
    Endocrinol Diabetes Metab Case Rep 2017 10;2017. Epub 2017 Jul 10.
    Department of Endocrinology, Royal Hallamshire Hospital, University of Sheffield, SheffieldUK.
    The granulation pattern of somatotroph adenomas is well known to be associated with differing clinical and biochemical characteristics, and it has been shown that sparsely granulated tumours respond poorly to commonly used somatostatin receptor ligands (SRLs). We report a challenging case of acromegaly with a sparsely granulated tumour resistant to multiple modalities of treatment, ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented with classical features of acromegaly, which was confirmed by an oral glucose tolerance test. Read More

    Current perspectives in the USA on the diagnosis and treatment of pelvic inflammatory disease in adolescents.
    Adolesc Health Med Ther 2017 27;8:87-94. Epub 2017 Jun 27.
    Department of Family Medicine, Oregon Health and Sciences University, Portland, OR, USA.
    In this review, the epidemiology, diagnosis, and treatment of pelvic inflammatory disease (PID) are discussed from a USA perspective and the difficulties that USA adolescents face in recognizing and seeking care for PID and other sexually transmitted infections (STIs) are emphasized. Females aged 15-24 years have the highest incidence of cervical infection with Chlamydia trachomatis and Neisseria gonorrheae, the principal causes of PID. PID is common in this age group. Read More

    Food protein-induced enterocolitis syndrome - a review of the literature with focus on clinical management.
    J Asthma Allergy 2017 27;10:197-207. Epub 2017 Jun 27.
    Geneva University Hospitals, Pediatric Allergology Unit, Geneva, Switzerland.
    Food protein-induced enterocolitis syndrome (FPIES) is a potentially severe presentation of non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) with heterogeneous clinical manifestations. Acute FPIES is typically characterized by profuse vomiting and lethargy, occurring classically 1-4 hours after ingestion of the offending food. When continuously exposed to the incriminated food, a chronic form has been described with persistent vomiting, diarrhea, and/or failure to thrive. Read More

    Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation.
    Drug Des Devel Ther 2017 28;11:1951-1956. Epub 2017 Jun 28.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University.
    Background: Dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of Gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. The objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (PK) index in healthy volunteers and in vitro antibacterial activity by using Monte Carlo simulation.

    Materials And Methods: A total of 867 clinical isolates from community-onset infections were collected from 31 secondary hospitals in People's Republic of China. Read More

    Not performing an OGTT results in significant underdiagnosis of (pre)diabetes in a high risk adult Caucasian population.
    Int J Obes (Lond) 2017 Jul 19. Epub 2017 Jul 19.
    University of Antwerp, Dept. of Medicine, Antwerp, Belgium.
    Objective: Type 2 diabetes (T2DM) is known to be underdiagnosed. Tests for diagnosis include fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) and HbA1c. HbA1c can be tested in non-fasting conditions. Read More

    Case Report: Diagnosis of hypogeusia after oral exposure to commercial cleaning agent and considerations for clinical taste testing.
    F1000Res 2017 28;6:373. Epub 2017 Mar 28.
    Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
    Few reports in the literature document acute taste disturbance following exposure to toxic chemicals. We describe the case of a 54-year-old man who presented with primary complaint of tongue numbness and persistent problems with taste 1.5 years following oral exposure to a commercial cleaning agent. Read More

    Enantiomeric separation of seven β-agonists by NACE-Study of chiral selectivity with diacetone-d-mannitol-boric acid complex.
    J Pharm Biomed Anal 2017 Jul 8;145:399-405. Epub 2017 Jul 8.
    Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
    A rapid and effective nonaqueous capillary electrophoresis (NACE)-ultraviolet (UV) method was developed for the enantiomeric separation of seven β-agonists. Diacetone-d-mannitol-boric acid complex was used as a new chiral selector. It was in situ synthesized by the reaction of diacetone-d-mannitol and boric acid in methanol medium containing triethylamine. Read More

    The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab.
    Pharmacogenomics J 2017 Jul 18. Epub 2017 Jul 18.
    Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Disease, Rheumatology, Oncologic Center, Laboratory for Immunological and Molecular Cancer Research, Paracelsus Medical University, Salzburg, Austria.
    FCGR2A-H131R and FCGR3A-V157F are single-nucleotide polymorphisms known to influence the outcome of patients treated with rituximab, cetuximab and trastuzumab. We investigated the impact of these polymorphisms on the clinical outcome of 103 patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with a platinum compound, fluorouracil and cetuximab as palliative first-line therapy. The survival of patients with FCGR2A-131H/H and/or FCGR3A-157V/V genotypes was significantly longer compared with patients carrying 131R and 157F alleles (median progression-free survival (PFS): 5. Read More

    Difficult Intubation and Ventilation in an Infant With Retropharyngeal Abscess With Mediastinal Extension.
    Pediatr Emerg Care 2017 Jul 17. Epub 2017 Jul 17.
    From the *University of Pittsburgh School of Medicine, Pittsburgh, PA; †Department of Anesthesiology, University of Pittsburgh; and ‡Division of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA.
    A previously healthy 7-month-old male infant presented for evaluation of fever, deceased oral intake, and intermittent noisy breathing. Physical examination revealed neck tenderness. Soft tissue neck radiographs and computed tomography (CT) scan supported a diagnosis of retropharyngeal swelling with extension to the superior mediastinum. Read More

    A Peculiar Form of Breast Fat Necrosis Simulating Hyaline Ring Granuloma (So-called Pulse Granuloma): A Rare Complication of Hyperparathyroidism.
    Int J Psychiatry Med 2017 Jul 1:1066896917720031. Epub 2017 Jul 1.
    2 Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
    Pulse granuloma is a rare, foreign body inflammatory reaction that occurs mainly in the oral cavity. It is exceedingly rare elsewhere, with only isolated cases described in the literature. We report the case of a 79-year-old woman with a history of normocalcemic hyperparathyroidism who presented to our hospital with a painful 4-cm lump in the upper quadrants-upper outer quadrant of her left breast. Read More

    Granulomatous reaction to hyaluronic acid filler material in oral and perioral region: A case report and review of literature.
    J Cosmet Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Faculdade de Odontologia, Departamento de Clínica, Patologia e Cirurgia Odontológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    The use of cosmetic fillers agents in orofacial region has become more often used for esthetic concern. Although adverse effects are rare, some patients may develop foreign body reaction to such fillers. Hyaluronic acid (HA) is a biomaterial in the spotlight, because it is normally present in several tissues of human body. Read More

    Application of the Biopsy-Sparing ESPGHAN Guidelines for Celiac Disease Diagnosis in Adults: A Real-Life Study.
    Dig Dis Sci 2017 Jul 17. Epub 2017 Jul 17.
    Department of Medicine and Ageing Sciences and Center for Excellence On Ageing and Translational Medicine (CeSI-MeT), "G. D'Annunzio" University and Foundation, Chieti, Italy.
    Background: Current adult celiac disease diagnosis requires histological confirmation. However, pediatric guidelines have proposed biopsy-sparing algorithms.

    Aims: To explore the applicability of the ESPGHAN criteria and assess the accuracy of serology in predicting disease in adults. Read More

    Diagnostic value of alarm symptoms for upper GI malignancy in patients referred to GI clinic: A 7 years cross sectional study.
    J Res Med Sci 2017 21;22:76. Epub 2017 Jun 21.
    Department of Oral and Maxillofacial Radiology, Islamic Azad University, Khorasgan Branch, Isfahan, Iran.
    Background: Early upper gastrointestinal (UGI) cancer detection had led to organ-preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy. Read More

    Ameloblastic Carcinoma: A Rare Malignant Tumour in Maxillofacial Region.
    J Maxillofac Oral Surg 2017 Sep 3;16(3):377-381. Epub 2016 Oct 3.
    Department of Oral Diagnosis and Radiology, Sinhgad Dental College and Hospital, S. No. 44/1, Vadgaon (Bk), Off Sinhagad Road, Pune, Maharashtra 411 041 India.
    Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with poor prognosis. It has an aggressive clinical course with extensive local destruction. It occurs primarily in the mandible. Read More

    Air Leak into the Soft Tissues During the Puffed Cheek CT Evaluation of Oral Cavity: Diagnosis and Implication of a Rare Phenomenon.
    J Maxillofac Oral Surg 2017 Sep 30;16(3):374-376. Epub 2016 Aug 30.
    Department of Radiology, Narayana Health, Mazumdar Shaw Medical Center, 309, Greenwoods Apt, Bommasandra, Bangalore, 560099 India.
    Leakage of small pockets of air in to soft tissues of cheek along vascular bundle is reported in a patient with ulcerated oral malignancy with history of recent biopsy. Leakage occurred during an attempt to puff the cheek during CT examination of oral cavity. Hereto undocumented phenomenon was self limiting and did not lead to clinical disability. Read More

    Cervical Metastases Behavior of T1-2 Squamous Cell Carcinoma of the Tongue.
    J Maxillofac Oral Surg 2017 Sep 28;16(3):300-305. Epub 2016 Jun 28.
    Department of Oral and Maxillofacial Surgery, University Medical Center, Johannes Gutenberg-University of Mainz, Augustusplatz 2, 55131 Mainz, Germany.
    Introduction: The cervical lymph node metastasis (CM) is one of the most important prognostic factors for oral squamous cell carcinoma. Although the frequency and distribution of CM for tongue carcinoma (TC) are well documented in the literature, there is only little data on metastasis patterns depending on the location of the cancer within the tongue.

    Materials And Methods: In a retrospective study all patients with a T1-T2 TC who were treated between 1997 and 2013 were analysed regarding epidemiological data, risk factors, and tumour parameters such as exact localization, CM. Read More

    Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review.
    Intern Med 2017 15;56(14):1879-1884. Epub 2017 Jul 15.
    Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
    A 61-year-old woman with chronic-type adult T-cell leukemia-lymphoma (ATL) had been taking low-dose oral etoposide for progressive lymphocytosis. After taking this for 3.5 years, she was diagnosed with therapy-related acute myeloid leukemia (t-AML), with a chromosomal translocation of t (6:11) (q27; q23). Read More

    Quantitation of DNA methylation in Epstein-Barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing.
    BMC Cancer 2017 Jul 17;17(1):489. Epub 2017 Jul 17.
    Department of Otorhinolaryngology, Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
    Background: Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and is highly associated with Epstein-Barr virus (EBV) infection. Significant changes of the host cell methylome are observed in EBV-associated NPC with cancer development. Read More

    The Complex Interaction Between Polycystic Ovary Syndrome and Hereditary Angioedema: Case Reports and Review of the Literature.
    Obstet Gynecol Surv 2017 Jul;72(7):417-424
    Gynecologist/Obstetrician, Disciplina de Ginecologia; Associate Professor, Disciplina de Ginecologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Importance: Hereditary angioedema (HAE) is a rare but severe disease, with high risk of death, and attacks have been associated to high estrogen levels. Polycystic ovary syndrome (PCOS) is a common hyperandrogenic condition, which is frequently treated with combined oral contraceptives.

    Objective: The aim of this study was to describe 2 clinical cases of young women diagnosed as having PCOS who developed HAE attacks after the introduction of combined estrogen-progestin pills to treat PCOS symptoms. Read More

    Simple platelet markers: Mean platelet volume and congestive heart failure coexistent with periodontal disease. Pilot studies.
    Cardiol J 2017 Jul 17. Epub 2017 Jul 17.
    Department of Oral Medicine and Periodontal Disease, Medical University of Warsaw, Poland.
    Background: Conducted pilot study concerning mean platelet volume parameter among patients suffering from congestive heart failure and periodontal disease.

    Methods: Examination of dynamic changes of platelet and periodontal markers in group of 50 patients before and an average of 6 months subsequent to professional periodontal treatment.

    Results: Both platelet and periodontal parameters decreased after periodontal treatment, what is more, the decrease of mean platelet volume (MPV) value due to periodontal disease/mm improvement was shown to be statistically significant (p = 0. Read More

    Chondrodysplasia Punctata: A Case Report of Fetal Warfarin Syndrome.
    J Nepal Health Res Counc 2017 Jan;15(35):81-84
    Department of Radiology and Imaging, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
    Chondrodysplasia punctata is abnormal calcification in the cartilage of developing bones and has been seen in association with deranged vitamin K metabolism. Warfarin, an oral anticoagulant acting on vitamin K dependent clotting factors is known to cause chondrodysplasia punctata. Despite the knowledge of the condition the management of patients with prosthetic heart valves might require use of the drug for anticoagulation. Read More

    Human platelet lysate supports the formation of robust human periodontal ligament cell sheets.
    J Tissue Eng Regen Med 2017 Jul 17. Epub 2017 Jul 17.
    State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi'an, P. R. China.
    The use of stem cell-derived sheets has become increasingly common in a wide variety of biomedical applications. Although substantial evidence has demonstrated that human platelet lysate (PL) can be used for therapeutic cell expansion, either as a substitute for or as a supplement to xenogeneic fetal bovine serum (FBS), its impact on cell sheet production remains largely unexplored. In this study, we manufactured periodontal ligament stem cell (PDLSC) sheets in vitro by incubating PDLSCs in sheet-induction media supplemented with various ratios of PL and FBS, i. Read More

    The differential regulation of microRNAs is associated with oral cancer.
    Oncol Rep 2017 Jul 12. Epub 2017 Jul 12.
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
    Oral squamous cell carcinoma (OSCC), is the most frequently occurring malignant head and neck tumor, generally it exhibits a poor prognosis, and metastasis is the main cause of death in these cancer patients. The discovery of reliable prognostic indicators for tumors progression would greatly improve clinical treatments. MicroRNAs (miRNAs) play a critical role in the degradation of mRNA and the inhibition of protein synthesis. Read More

    Validated Questionnaire of Maternal Attitude and Knowledge for Predicting Caries Risk in Children: Epidemiological Study in North Jakarta, Indonesia.
    J Int Soc Prev Community Dent 2017 Jun 20;7(Suppl 1):S42-S47. Epub 2017 Jun 20.
    Department of Paediatric Dentistry, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
    Aims And Objectives: Predicting caries risk in children can be done by identifying caries risk factors. It is an important measure which contributes to best understanding of the cariogenic profile of the patient. Identification could be done by clinical examination and answering the questionnaire. Read More

    Prosthetic Consideration in Implant-supported Prosthesis: A Review of Literature.
    J Int Soc Prev Community Dent 2017 Jun 20;7(Suppl 1):S1-S7. Epub 2017 Jun 20.
    Department of Public Health Dentistry, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India.
    Modern dentistry has changed tremendously with implant therapy. For the successful implant therapy, making a proper treatment plan considering both surgical and prosthetic part in mind is the key of success. Often practitioners tend to create a treatment plan overlooking the basic principles of prosthetic part. Read More

    Two Concurrent Large Epidermoid Cysts in Sublingual and Submental Region Resembling Plunging Ranula: Report of a Rare Case.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):155-158
    Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.
    An elderly female patient presented to surgical outpatient clinic with complaint of gradual onset of painless submental and sublingual midline swellings for 6 months of duration. The swellings were noncompressible, nontranslucent, nonpulsatile, and nontender on palpation. Clinical diagnosis was plunging ranula or dermoid cysts. Read More

    A Rare Report of Two Cases: Ancient Schwannoma of Infratemporal Fossa and Verocay Schwannoma of Buccal Mucosa.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):140-142
    Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Schwannoma is a benign tumor that originates from Schwann cells of the peripheral nerve. Occurring as a common tumor in the head and neck region, its intraoral presentation is rare which accounts for only 1%. They are solitary, slow-growing, smooth-surfaced, usually asymptomatic, and encapsulated tumor. Read More

    Bone Ring Augmentation Around Immediate Implants: A Clinical and Radiographic Study.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):92-97
    Department of Oral and Maxillofacial Surgery, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
    Purpose: The purpose of this study was to evaluate the efficacy of bone ring augmentation technique for three-dimensional augmentation of severely defective sockets along with placement of immediate dental implants.

    Materials And Methods: A clinical study was conducted on 14 patients with 15 defective sockets requiring extractions and immediate implant placement. Following extraction, bone ring with an implant osteotomy, harvested from chin, was sculptured and fitted into the extraction socket. Read More

    Effectiveness of Preoperative Lymphoscintigraphy for the Detection of Cervical Lymph Node Metastasis in Patients with Oral Squamous Cell Carcinoma.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):30-36
    Department of Oral and Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka-1000, Bangladesh.
    Background: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumor. OSCC is the malignancy of squamous epithelium of oral cavity, which is the sixth most common malignancy reported worldwide and one with highest mortality rate among all malignancies.

    Aims: The aims of this study is to assess the diagnostic performance of lymphoscintigraphy (LSG) for the detection of cervical lymph node metastasis in patients with OSCC. Read More

    Therapeutic Evaluation of Cervical Dysfunction in Patients with Myofascial Pain Dysfunction Syndrome: A Prospective Study.
    J Contemp Dent Pract 2017 Jul 1;18(7):601-606. Epub 2017 Jul 1.
    Department of Orthopedics, NKP Salve Institute of Medical Sciences & Research Center, Nagpur, Maharashtra, India.
    Aim: The aim of this study was to find out the therapeutic correlation between cervical dysfunction and myofascial pain dysfunction syndrome (MPDS).

    Materials And Methods: The study included 46 patients out of which 23 had MPDS with cervical pain (group I), and 23 patients had only MPDS (group II). Detailed history and examination of the patients were carried out, and the factors taken into consideration were pain and tenderness of muscles of mastication and neck muscles, maximum comfortable mouth opening, and cervical range of motion. Read More

    Retrospective Assessment of Healing Outcome of Endodontic Treatment for Mandibular Molars with C-shaped Root Canal.
    J Contemp Dent Pract 2017 Jul 1;18(7):591-595. Epub 2017 Jul 1.
    Department of Oral Medicine & Radiology, Institute of Dental Science & Sum Hospital, Bhubaneswar, Orrisa, India.
    Introduction: A thorough knowledge of the anatomic morphology of the root canal system is necessary for the long-term success of the root canal therapy. The occurrence of C-shaped root canal configuration is one such variation. Achievement of favorable prognosis after commencing root canal therapy in such teeth is one of the challenges imposed on the endodontist. Read More

    Assessment of the Effect of Orthodontic Treatment on the Periodontal Health of Endodontically Restored Tooth.
    J Contemp Dent Pract 2017 Jul 1;18(7):587-590. Epub 2017 Jul 1.
    Department of Conservative Dentistry and Endodontics Narsinhbhai Patel Dental College & Hospital, Visnagar, Gujarat India.
    Intorduction: Patients usually undergo orthodontic treatment for achieving ideal interocclusal relationship between the dental tissue and bony tissue along with improving the speech, mastication, and facial esthetic appearance. Literature quotes paucity in the studies evaluating the effect of orthodontic treatment on the periodontal health of endodontically treated teeth. Hence, we planned the present study to assess the effect of orthodontic treatment on the periodontal health of endodonti-cally restored tooth. Read More

    Prevalence of Dental Anomalies in Odisha Population: A Panoramic Radiographic Study.
    J Contemp Dent Pract 2017 Jul 1;18(7):549-553. Epub 2017 Jul 1.
    Department of Oral Pathology and Microbiology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, University, Bhubaneswar, Odisha, India, Phone: +919178358687, e-mail:
    Aim: The aim of this study was to evaluate the prevalence of dental anomalies (DAs) in Odisha population using panoramic radiographs.

    Materials And Methods: In this study, 1,080 panoramic radiographs were evaluated for DAs. Dental records were reviewed for diagnostic confirmation. Read More

    Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial.
    Lancet 2017 Jul 13. Epub 2017 Jul 13.
    Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Background: Phase 1 studies have shown potential benefit of gene replacement in RPE65-mediated inherited retinal dystrophy. This phase 3 study assessed the efficacy and safety of voretigene neparvovec in participants whose inherited retinal dystrophy would otherwise progress to complete blindness.

    Methods: In this open-label, randomised, controlled phase 3 trial done at two sites in the USA, individuals aged 3 years or older with, in each eye, best corrected visual acuity of 20/60 or worse, or visual field less than 20 degrees in any meridian, or both, with confirmed genetic diagnosis of biallelic RPE65 mutations, sufficient viable retina, and ability to perform standardised multi-luminance mobility testing (MLMT) within the luminance range evaluated, were eligible. Read More

    The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis.
    J Am Dent Assoc 2017 Jul 13. Epub 2017 Jul 13.
    Background: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants.

    Methods: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. Read More

    Primary Empty Sella Syndrome Presenting With Severe Hyponatremia And Minimal Salt Wasting.
    J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):605-608
    Department of Internal Medicine, Dubai Hospital, Dubai Health Authority, U.A.E.
    A 41 year old Jordanian gentleman known case of osteogenesis imperfecta presented with vomiting, decreased oral intake followed by confusion. At presentation he was found to have signs of hypogonadism with severe hyponatremia. The hyponatremia responded to intravenous steroid replacement . Read More

    Association Of Serum Total Bilirubin Level With Diabetic Retinopathy In Type 2 Diabetes Mellitus.
    J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):537-541
    Department of Endocrinology, Diabetes & Metabolic Diseases, Hayatabad Medical Complex Peshawar, Pakistan.
    Background: Serum bilirubin has anti-inflammatory, antioxidant and immunological properties. It is considered a protective substance against atherosclerotic and microvascular complications of diabetes mellitus (DM). This study was designed to find the association between total serum bilirubin concentration and diabetic retinopathy (DR). Read More

    Giant Cementoblastoma Of Left Maxilla Involving A Deciduous Molar.
    J Ayub Med Coll Abbottabad 2017 Jan-Mar;29(1):145-146
    DDepartment of Oral and Maxillofacial Surgery, Ayub Teaching Hospital Abbottabad, Pakistan.
    Cementoblastoma is a relatively rare benign tumour. The clinicopathologic features, radiological findings, treatment and prognosis are reported here in a 10-year-old girl who presented to us from Afghanistan. The tumor was managed surgically and the histopathology confirmed the diagnosis of cementoblastoma. Read More

    Anesthetic Management of Reversible Cerebral Vasoconstriction Syndrome: A Case Report.
    J Oral Maxillofac Surg 2017 Jun 14. Epub 2017 Jun 14.
    Professor, Department of Anesthesiology, Saitama Medical University Hospital, Saitama, Japan.
    Reversible cerebral vasoconstriction syndrome (RCVS) is a group of disorders characterized by prolonged reversible cerebral vasoconstriction, associated with acute-onset, severe, episodic "thunderclap" headaches with or without other neurologic clinical features. We describe the first reported case, to our knowledge, of a patient with RCVS who was managed under general anesthesia in the field of oral and maxillofacial surgery. A 67-year-old woman with a diagnosis of RCVS made 2 months earlier was scheduled to undergo surgical extraction of the mandibular right third molar. Read More

    Acquired heterotopic ossification of the temporomandibular joint.
    Int J Oral Maxillofac Surg 2017 Jul 12. Epub 2017 Jul 12.
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.
    Although the risk factors and diagnosis of heterotopic ossification (HO) are discussed in the orthopedics literature, the etiology of HO, as well as its prevention and management, remain theoretical. Furthermore, there is a lack of information in the literature regarding HO in temporomandibular joint replacement (TMJR). This article provides a qualitative review of information relative to the etiology, diagnosis, and management of HO to inform and encourage further investigation in TMJR. Read More

    Eldecalcitol (ED-71), an analog of 1α,25(OH)2D3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2.
    In Vitro Cell Dev Biol Anim 2017 Jul 14. Epub 2017 Jul 14.
    Department of Molecular Oral Medicine and Maxillofacial Surgery, Division of Applied Life Sciences, Graduate Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
    Heparin-binding protein 17 (HBp17)/fibroblast growth factor-binding protein-1 (FGFBP-1) was first purified from medium conditioned by A431 cells for its capacity to bind to fibroblast growth factors 1 and 2 (FGF-1 and -2). Among FGF family members, FGF-2 is a potent mitogen for various cell types, including vascular endothelial cells, fibroblasts, and cancer cells such as oral squamous cell carcinoma (OSCC) cells. Besides being well known in bone metabolism, the active form of vitamin D3, i. Read More

    Disseminated histoplasmosis presenting as multiple oral ulcers.
    BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.
    Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
    A 61-year-old female with a history of advanced HIV disease and chronic hepatitis B was presented with an 8-week history of painful oral ulcers. She appeared systemically well but examination revealed multiple well-demarcated clean-based ulcers on the tongue and hard palate. Biopsy of one of the lesions showed numerous histiocytes containing intracellular yeast forms consistent with Histoplasma capsulatum var. Read More

    Specific allergen profiles of peanut foods and of diagnostic or therapeutic allergenic products.
    J Allergy Clin Immunol 2017 Jul 11. Epub 2017 Jul 11.
    INDOOR Biotechnologies Inc., Charlottesville, VA. Electronic address:
    Rationale: 'Generic' immunoassays for peanut cannot discriminate between allergen levels in peanut derived food products or therapeutics. Clinical trials of oral immunotherapy are strengthened by using standardized peanut preparations, with defined doses of major allergens.

    Objective: This paper describes measurement of Ara h 1, Ara h 2 and Ara h 6 in peanut foods and in peanut flour extracts used for allergy diagnosis and oral immunotherapy. Read More

    Risk of Second Primary Malignancies in Patients With Follicular Lymphoma: A United States Population-based Study.
    Clin Lymphoma Myeloma Leuk 2017 Jun 24. Epub 2017 Jun 24.
    Division of Hematology-Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
    Background: With the improving outcomes of patients with follicular lymphoma (FL), it is imperative to focus on survivorship issues, including the development of second primary malignancies (SPMs). We used a large US database to measure the risk of SPMs among FL survivors.

    Materials And Methods: We used the Surveillance, Epidemiology, and End Results-13 registry to identify FL patients from 1992 to 2011. Read More

    Prevalence of paroxysmal atrial fibrillation in a population assessed by continuous 24-hour monitoring.
    Rev Port Cardiol 2017 Jul 11. Epub 2017 Jul 11.
    Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
    Introduction: A trial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and a major cause of morbidity, due to the associated risk of stroke. However, since it is often paroxysmal, it is commonly underdiagnosed and undertreated.

    Objectives: The primary objective of this prospective study was to determine the prevalence of paroxysmal atrial fibrillation (PAF) in patients aged 40 and above in a population who underwent continuous 24-hour electrocardiographic monitoring. Read More

    Surgical Margins: The Perspective of Pathology.
    Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):367-375
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address:
    Neoplasms of the head and neck constitute a broad spectrum of benign and malignant entities. When treatment involves resection, assessment of the surgical margins represents an important component of the pathologic examination. Margin status is an important indicator of a complete surgical resection. Read More

    Margin Analysis: Sarcoma of the Head and Neck.
    Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):355-366
    Head and Neck Oncologic Surgery and Microvascular Fellowship, Division of Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, University of Florida Health Science Center, Jacksonville, University of Florida College of Medicine, 653 West 8th Street, Jacksonville, FL 32209, USA.
    Head and neck sarcomas are rare but are associated with significant morbidity/mortality and management difficulties. These tumors are best managed in a multidisciplinary setting. Open or core biopsy is essential for histologic diagnosis and grading. Read More

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