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    Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells.
    Virology 2018 Apr 17;519:64-73. Epub 2018 Apr 17.
    MOE Joint International Research Laboratory of Animal Immunology, Nanjing Agricultural University, Nanjing, China; Key Laboratory of Animal Virology, Ministry of Agriculture, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou, China. Electronic address:
    Influenza A viruses have sophisticated strategies to promote their own replication. Here, we found that three H5N1 influenza viruses display different replication patterns in human A549 and macrophage cells. The HN01 virus displayed poor replication compared to HN021 and JS01. Read More

    Innovative perception on using Tiron to modulate the hepatotoxicity induced by titanium dioxide nanoparticles in male rats.
    Biomed Pharmacother 2018 Apr 17;103:553-561. Epub 2018 Apr 17.
    Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Electronic address:
    The extensive application of titanium dioxide nanoparticles (TiO NPs) in the food industry arouses a debate regarding the probable risk associated with their use. Several recent studies reported that most nanoparticles (NPs) have adverse actions on the liver. The objective of this study is to examine whether Tiron plays a modulatory role against apoptotic damage induced by TiO NPs in rat livers. Read More

    Optimisation of three-dimensional lower jaw resection margin planning using a novel Black Bone magnetic resonance imaging protocol.
    PLoS One 2018 20;13(4):e0196059. Epub 2018 Apr 20.
    Department of Oral and Maxillofacial Surgery, University Medical Centre Groningen, Groningen, The Netherlands.
    Background: MRI is the optimal method for sensitive detection of tumour tissue and pre-operative staging in oral cancer. When jawbone resections are necessary, the current standard of care for oral tumour surgery in our hospital is 3D virtual planning from CT data. 3D printed jawbone cutting guides are designed from the CT data. Read More

    Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components.
    Nutrients 2018 Apr 20;10(4). Epub 2018 Apr 20.
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110000, China.
    Strychnos alkaloids (SAs) are the main toxic constituents in Semen Strychni, a traditional Chinese medicine, which is known for its fatal neurotoxicity. Hence, the present study was carried out to evaluate the neurotoxicity induced by SAs and the pre-protective effects of the total glucosides of Paeoniae Radix Alba (TGP). An SA brain damage model was firstly established. Read More

    A Novel Splicing Mutation of Ectodysplasin A Gene Responsible for Hypohidrotic Ectodermal Dysplasia.
    Oral Dis 2018 Apr 20. Epub 2018 Apr 20.
    Peking University School and Hospital of Stomatology, Department of Pediatric Dentistry.
    Hypohidrotic ectodermal dysplasia (HED) is characterized by hypohidrosis, hypodontia, sparse hair and characteristic facial features. This condition is caused by an ectodysplasin A (EDA) gene mutation. In this study, we examined two HED pedigrees and investigated the molecular genetics of the defect. Read More

    Clinical Implications of Using Post-Challenge Plasma Glucose Levels for Early Diagnosis of Type 2 Diabetes Mellitus in Older Individuals.
    Diabetes Metab J 2018 Apr;42(2):147-154
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
    Background: The aim of this study was to explore the differences in the clinical characteristics and diagnostic rates of diabetes mellitus (DM) according to various criteria in different age groups and to evaluate the efficacy of each criterion for screening older patients.

    Methods: We studied 515 patients and measured the fasting plasma glucose level (FPG), 2-hour plasma glucose level after the 75 g oral glucose tolerance test (2-hour postload glucose [2-h PG]), and glycosylated hemoglobin (HbA1c) for re-evaluation of hyperglycemia without a history of diabetes. Patients with newly diagnosed DM were grouped by age as younger (<65 years) or older (≥65 years). Read More

    Treatment of ankylosing spondylitis with co-amoxiclav.
    Clin Exp Pharmacol Physiol 2018 Apr 19. Epub 2018 Apr 19.
    Consulting physician Department of Physical Medicine and Rehabilitation, Seyfi Demirsoy State Hospital, Buca, Izmir, Turkey.
    This article presents the efficacy of co-amoxiclav in two patients with ankylosing spondylitis. Both patients were administered oral co-amoxiclav for 7 days. The primary efficacy variable was the ankylosing spondylitis activity index. Read More

    Improving the Recording of Diagnoses in Primary Care with Team Incentives: A Controlled Longitudinal Follow-Up Study.
    Biomed Res Int 2018 20;2018:4606710. Epub 2018 Feb 20.
    Centre for Research Methods, Department of Social Research, University of Helsinki, P.O. Box 18, Unioninkatu 35, 00014 Helsinki, Finland.
    Introduction: We studied whether primary care teams respond to financial group bonuses by improving the recording of diagnoses, whether this intervention leads to diagnoses reflecting the anticipated distribution of diseases, and how the recording of a significant chronic disease, diabetes, alters after the application of these bonuses.

    Methods: We performed an observational register-based retrospective quasi-experimental follow-up study with before-and-after setting and two control groups in primary healthcare of a Finnish town. We studied the rate of recorded diagnoses in visits to general practitioners with interrupted time series analysis. Read More

    Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages.
    Biomed Opt Express 2018 Apr 2;9(4):1461-1476. Epub 2018 Mar 2.
    Institute of Biophotonics, National Yang-Ming University, Taipei 112, Taiwan.
    Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Read More

    Efficacy of denoising and enhancement filters for detection of approximal and occlusal caries on digital intraoral radiographs.
    J Conserv Dent 2018 Mar-Apr;21(2):162-168
    Department of Oral and Maxillofacial Radiology, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
    Background And Objectives: Image processing and enhancement filters can significantly improve the diagnostic value of digital radiographs. Evidence shows that increasing the contrast and filtering improve the diagnostic accuracy for caries detection. This study sought to assess the diagnostic accuracy of original and enhanced digital radiographs for the detection of approximal and occlusal caries. Read More

    Effects of tocotrienol from Bixa orellana (annatto) on bone histomorphometry in a male osteoporosis model induced by buserelin.
    Biomed Pharmacother 2018 Apr 16;103:453-462. Epub 2018 Apr 16.
    Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Malaysia. Electronic address:
    Introduction: Osteoporosis is a debilitating skeletal side effect of androgen deprivation therapy based on gonadotropin-releasing hormone (GnRH) agonist in men. Tocotrienol from Bixa orellana (annatto) has been demonstrated to offer protection against osteoporosis by exerting anabolic effects on bone. Thus, it may prevent osteoporosis among GnRH agonist users. Read More

    4-Fluorobenzaldehyde limonene-based thiosemicarbazone induces apoptosis in PC-3 human prostate cancer cells.
    Life Sci 2018 Apr 16. Epub 2018 Apr 16.
    Laboratório de Farmacologia e Toxicologia Celular, FarmaTec, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil. Electronic address:
    Aims: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells.

    Main Methods: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry. Read More

    Relationship Between Intracapsular Fracture Patterns and Arthroscopic Findings.
    J Oral Maxillofac Surg 2018 Mar 27. Epub 2018 Mar 27.
    Emeritus Professor, Oral and Maxillofacial Surgery Unit, Faculty of Health Science University of Adelaide, Adelaide, SA, Australia.
    Purpose: To observe the superior joint compartment (SJC) using ultrathin arthroscopy in intracapsular condylar fracture (ICF) of the temporomandibular joint, describe the changes, and evaluate the relations among fracture pattern, arthroscopic findings, and clinical outcome.

    Patients And Methods: Twenty patients with 27 ICFs were the subject group. Thirteen patients had unilateral ICF and 7 had bilateral ICF. Read More

    Clinical features and presentation of oral potentially malignant disorders.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Apr 4. Epub 2018 Apr 4.
    Emeritus Professor, King's College London, UK; WHO Collaborating Centre for Oral Cancer, London, UK. Electronic address:
    Oral potentially malignant disorders (OPMDs) are conditions that precede the onset of invasive cancers of the oral cavity. The term embraces precancerous lesions and conditions referred to in earlier World Health Organization (WHO) definitions. Leukoplakia is the most common OPMD; erythroplakia, although rare, is more serious. Read More

    [Primary cutaneous CD30+ T-cell lymphoproliferation during treatment with fingolimod: Case report and literature review].
    Ann Dermatol Venereol 2018 Apr 16. Epub 2018 Apr 16.
    Service de dermatologie et d'allergologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; Faculté de médecine, Sorbonne université, 75013 Paris, France. Electronic address:
    Background: Fingolimod is an oral immunomodulator approved for relapsing-remitting multiple sclerosis. We report a case of a primary cutaneous CD30+ T-cell lymphoproliferation occurring 6 months after initiation of fingolimod. Based on a systematic literature review, the characteristics of these fingolimod-induced lymphoproliferative disorders are described. Read More

    Subchronic Oral Toxicity of Silica Nanoparticles and Silica Microparticles in Rats.
    Biomed Environ Sci 2018 Mar;31(3):197-207
    Key Laboratory of Food Safety Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
    Objective: To investigate the subchronic oral toxicity of silica nanoparticles (NPs) and silica microparticles (MPs) in rats and to compare the difference in toxicity between two particle sizes.

    Methods: Sprague-Dawley rats were randomly divided into seven groups: the control group; the silica NPs low-, middle-, and high-dose groups; and the silica MPs low-, middle-, and high-dose groups [166.7, 500, and 1,500 mg/(kg•bw•day)]. Read More

    Diphyllobothriasis in a U.S. Military Aviator.
    Aerosp Med Hum Perform 2018 May;89(5):473-477
    Background: Diphyllobothriasis is estimated to afflict 10-20 million people worldwide; however, this is the first case reported in a United States military aviator. Among the largest parasites of humans, the "fish tapeworm" grows from 2-15 m in length, can live >20 yr in the intestines, and is contracted through consumption of uncooked, unfrozen freshwater or anadromous fish species.

    Case Report: A 32-yr-old male F-22 pilot presented with mild stomach cramping, bloating, nausea, and intermittent loose stools. Read More

    Adverse Events Associated with Antibiotics and Intravenous Therapies for Post-Lyme Disease Syndrome in a Commercially Insured Sample.
    Clin Infect Dis 2018 Apr 17. Epub 2018 Apr 17.
    Department of Pharmacy Practice, Midwestern University College of Pharmacy, Glendale, AZ, USA.
    Background: Non-guideline endorsed post-treatment courses of antibiotics for post-Lyme disease syndrome (PLDS) have been linked to adverse patient outcomes, but these findings have yet to be validated in large systematic evaluations.

    Methods: A retrospective cohort analysis of medical and pharmacy claims derived from the Truven Health Market Scan® Commercial Claims and Encounters Database assessed 90-day incidence rates of adverse events (AEs) associated with PLDS treatments (PLDS-TX). Patients were diagnosed with PLDS ≥6 months after initial diagnosis and standard antibiotic treatment for Lyme disease. Read More

    Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats.
    J Basic Clin Physiol Pharmacol 2018 Apr 19. Epub 2018 Apr 19.
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria, Phone: +2348023470333,
    Background: Oxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract of Chasmanthera dependens to protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats.

    Methods: The C. Read More

    Secondary prevention and lifestyle indices after stroke in a long-term perspective.
    Acta Neurol Scand 2018 Apr 19. Epub 2018 Apr 19.
    Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
    Objectives: To describe the long-term perspective regarding prevalence of risk factors, secondary stroke prevention, and lifestyle indices after stroke.

    Methods: From a population-based one-year cohort (n = 416), we performed an observational study of 145 survivors at 16 months and 10 years after stroke (age 27-97 years) regarding secondary prevention including reaching acceptable treatment goals; nutritional status with focus on underweight; and the lifestyle indices: living situation, level of dependence, and self-assessed health condition.

    Results: Ten years after stroke, 50% of the subjects with hypertension diagnosis and 55% of those without hypertension diagnosis were within the blood pressure goal <140/90 compared with 32% (P = . Read More

    Vaginitis: Diagnosis and Treatment.
    Am Fam Physician 2018 Mar;97(5):321-329
    Columbia University Irving Medical Center, New York, NY, USA.
    Vaginitis is defined as any condition with symptoms of abnormal vaginal discharge, odor, irritation, itching, or burning. The most common causes of vaginitis are bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. Bacterial vaginosis is implicated in 40% to 50% of cases when a cause is identified, with vulvovaginal candidiasis accounting for 20% to 25% and trichomoniasis for 15% to 20% of cases. Read More

    Effect of Non-vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation Patients with Newly Diagnosed Cancer.
    Korean Circ J 2018 Feb 26. Epub 2018 Feb 26.
    Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background And Objectives: There are limited data on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer. We aimed to assess the efficacy and safety of NOACs in AF patients with cancer in this study.

    Methods: In 2,568 consecutive non-valvular AF patients with newly diagnosed cancer, we analyzed ischemic stroke/systemic embolism (SE), major bleeding, and all-cause death. Read More

    Three days of high-dose glucocorticoid treatment attenuates large-vessel 18F-FDG uptake in large-vessel giant cell arteritis but with a limited impact on diagnostic accuracy.
    Eur J Nucl Med Mol Imaging 2018 Apr 18. Epub 2018 Apr 18.
    Department of Rheumatology, Aarhus University Hospital, Nørrebrogade 44, bygning 3, 8000, Århus C, Denmark.
    Purpose: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment.

    Methods: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy. Read More

    [Rectal bleeding in a 60-year-old woman under anticoagulation and platelet aggregation inhibition].
    Internist (Berl) 2018 Apr 18. Epub 2018 Apr 18.
    Notfall- und Akutmedizin mit Chest Pain Units, Campus Charité Mitte und Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
    Case Report: We report on a woman with lower gastrointestinal bleeding under effective oral anticoagulation with both phenprocoumon and apixaban (with intention to switch to the latter) as well as the antiplatelet agent acetylsalicylic acid for aortic bifurcation kissing stents after stent thrombosis. Our patient presented with weakness and rectal bleeding. Upon examination, she looked anemic and had sinus tachycardia (104 beats per minute). Read More

    Coexisting sublingual dermoid cyst and heterotopic gastrointestinal cyst: Case report.
    J Clin Exp Dent 2018 Feb 1;10(2):e196-e199. Epub 2018 Feb 1.
    Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Akdeniz University, Antalya, Turkey.
    A heterotopic oral gastrointestinal cyst coexisting with a lingual dermoid cyst is a rare condition, with only 3 reported cases in the English-language literature. Clinically, both gastrointestinal and dermoid cysts tend to manifest as an asymptomatic swelling. Cysts above the mylohyoid often present with sublingual swelling, whereas those below the mylohyoid present with submental swelling. Read More

    Gingival varices treated with monoethanolamine oleate: A rare case report.
    J Clin Exp Dent 2018 Feb 1;10(2):e192-e195. Epub 2018 Feb 1.
    Professor, Msc, PhD, Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal of Minas Gerais, Belo Horizonte, Brasil.
    Varices are benign blood vessel lesions that are common in the head and neck regions. The aim of this case report is to highlight an uncommon case of gingival varices and its diagnosis and management. This is the second time that a case of varices has been reported at this site. Read More

    Oral Bilateral Collagenous Fibroma: A previously unreported case and literature review.
    J Clin Exp Dent 2018 Jan 1;10(1):e96-e99. Epub 2018 Jan 1.
    MSc, Post Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas-RS, Brazil.
    Collagenous fibroma, also known as desmoplastic fibroblastoma, is a rare benign slow growing tumor particularly uncommon in the oral cavity. The aim of this study was to analyze the clinical and histopathological features of an oral collagenous fibroma as well as to compare this data with those reported in an English-literature review. The thirteenth case of collagenous fibroma in the oral cavity and the first to present clinically as a bilateral mass was described. Read More

    Plunging Ranula in a 78- year- old Male - a Rare Case Report.
    J Clin Exp Dent 2018 Jan 1;10(1):e92-e95. Epub 2018 Jan 1.
    Professor, Department of Oral Pathology and Microbiology, Tamilnadu government Dental College and Hospital, Chennai, India.
    The term Ranula is a Latin word meaning frog. It refers to a bluish translucent cystic lesion in the floor of the mouth resembling the underbelly of a frog. Ranulas can be true cysts occurring due to ductal obstruction of the sublingual gland or a minor salivary gland or a pseudocyst as a result of ductal injury leading to extravasation and accumulation of saliva in the surrounding tissues. Read More

    Stafne's bone defect in a metastatic prostate cancer patient: A diagnostic conundrum.
    J Clin Exp Dent 2018 Jan 1;10(1):e88-e91. Epub 2018 Jan 1.
    DDS, MSC, Dental Service, Instituto do Câncer do Estado de São Paulo, Sao Paulo, Brazil.
    Stafne's bone defect (SBD) is an uncommon bone alteration that affects the mandible and usually presents as an asymptomatic radiolucency located in the posterior region of body or angle of the mandible, below the alveolar canal. Although clinical and radiographic features are more often sufficient for the diagnosis, other lesions and bone alterations have been described in the differential diagnosis and may lead to a misinterpretation and an incorrect diagnosis. Herein, we report a case of an 89-yearold man with metastatic prostate cancer to multiple bones, presenting an asymptomatic solitary well-defined radiolucent image on the right side of the posterior body of the mandible, in close contact with its inferior border. Read More

    Clinical and Radiographic Assessment of Reasons for Replacement of Metal- Ceramic Fixed Dental Prostheses in Patients Referring to Dental School.
    J Clin Exp Dent 2018 Jan 1;10(1):e75-e80. Epub 2018 Jan 1.
    Associate Professor, Fixed prosthodontics Department, Faculty of Dentistry, Mansoura University, Egypt.
    Background: The expected length of service and reasons for fixed dental prostheses (FDPs) replacement are a frequent inquiry by patients while the answers were mainly based on studies reports that was conducted outside the middle east region. This clinical and radiographic survey was constructed to assess and survey clinically and radiographically the reasons of replacement of metal-ceramic fixed dental prostheses, amongst patients reporting at dental school in Taibah University.

    Material And Methods: Between January and May 2016, 151 patients were recruited for this study. Read More

    The Evaluation of Root Fracture with Cone Beam Computed Tomography (CBCT): An Epidemiological Study.
    J Clin Exp Dent 2018 Jan 1;10(1):e41-e48. Epub 2018 Jan 1.
    Oral and Tooth Health Center, Department of Pediatric Dentistry, Diyarbakir, Türkiye.
    Background: The aim of this study was evaluation of the cone-beam computed tomography (CBCT) image of 50 patients at the ages of 8-15 suspecting root fracture and root fracture occurred, exposed to dental traumatic. In additionally, this study was showed effect of crown fracture on root fracture healing.

    Material And Methods: All of the individuals included in the study were obtained images with the cone-beam computed tomography range of 0,3 voxel and 8. Read More

    Dynamic Alterations in Salivary Microbiota Related to Dental Caries and Age in Preschool Children With Deciduous Dentition: A 2-Year Follow-Up Study.
    Front Physiol 2018 4;9:342. Epub 2018 Apr 4.
    Department of Conservative Dentistry and Periodontics, The Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou, China.
    Dynamic alterations in oral microbiota are closely related to the development of dental caries;however, changes in salivary microbiota during this process have not been extensively studied. In addition, increasing evidence suggests that oral microbiome profiles differ according to dentition stages, but it is unclear whether they change with age during the same dentition, such as deciduous dentition. These two aspects were investigated in a 2-year follow-up study, and caries-free preschool children with complete deciduous dentition were enrolled. Read More

    Screening and management of gestational diabetes in Mexico: results from a survey of multilocation, multi-health care institution practitioners.
    Diabetes Metab Syndr Obes 2018 5;11:105-116. Epub 2018 Apr 5.
    Nestlé Research Center, Lausanne, Switzerland.
    Purpose: To identify the most common practices implemented for the screening and treatment of gestational diabetes mellitus (GDM) and to estimate the GDM clinician-reported proportion as a proxy of the incidence in Mexico.

    Materials And Methods: Three hundred fifty-seven physicians in four major cities were asked about their practices regarding GDM screening, treatment, clinical exams, and health care staff involved in case of GDM diagnosis, as well as the percentage of women with GDM they care for. Data management and statistical analyses were done with Stata 13. Read More

    The efficacy and safety of extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
    Drug Des Devel Ther 2018 5;12:735-742. Epub 2018 Apr 5.
    Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia.
    Background And Aim: Type 2 diabetes mellitus (T2DM) is one of the major diseases confronting the health care systems. In diabetes mellitus (DM), combined use of oral hypoglycemic medications has been shown to be more effective than metformin (Met) alone in glycemic control. This study determined the effects of (GKB) extract as an adjuvant to Met in patients with uncontrolled T2DM. Read More

    Three-dimensional diagnosis of dentin caries beneath composite restorations using swept-source optical coherence tomography.
    Dent Mater J 2018 Apr 17. Epub 2018 Apr 17.
    Cariology and Operative Dentistry, Oral Restitution Department, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
    The aims of this study were to assess the diagnostic accuracy of swept-source optical coherence tomography (SS-OCT) for detection of caries beneath composite restorations and to compare the results with those obtained by radiography. Flat dentin surfaces with and without natural caries were bonded with 1- or 2-mm thick composite restorations. SS-OCT scanning was performed over the composite restorations to construct three-dimensional (3D) images of the resin-dentin interface. Read More

    A case of H3N2 complicated by acute kidney injury secondary to rhabdomyolysis.
    BMJ Case Rep 2018 Apr 18;2018. Epub 2018 Apr 18.
    Department of Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    H3N2 was first detected in July 2011 in the USA. It is responsible for sporadic cases of influenza and localised outbreaks and has not yet taken over on an epidemic or pandemic scale. An 84-year-old man presented with a dry cough, fever and myalgia for 3 days. Read More

    Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug, prospective, non-randomised phase 2 trial.
    Lancet Respir Med 2018 Apr 12. Epub 2018 Apr 12.
    Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
    Background: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations.

    Methods: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK). Read More

    Nonprescription medications for respiratory symptoms: Facts and marketing fictions.
    Allergy Asthma Proc 2018 May;39(3):169-176
    Pharmacy and Pediatrics, University of Florida, Gainesville, Florida.
    Background: There are many nonprescription (over-the-counter [OTC]) medications available on pharmacy shelves marketed for relief of respiratory symptoms. The number of such medications has been increasing.

    Objective: This review provides an evidence-based examination of OTC products used for respiratory symptoms. Read More

    The effect of fenofibrate on early retinal nerve fiber layer loss in type 2 diabetic patients: a case-control study.
    BMC Ophthalmol 2018 Apr 18;18(1):100. Epub 2018 Apr 18.
    Department of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.
    Background: Previous studies suggested that use of fenofibrate could significantly reduce the rate of progression into diabetic retinopathy (DR), and that retinal nerve fiber layer (RNFL) loss, which has been considered an important indicator for retinal neurodegeneration, might precede microvascular changes. The aim of this study was to assess the effect(s) of fenofibrate on RNFL thickness at early stage of DR in patients with type 2 diabetes mellitus (DM).

    Methods: In this retrospective matched case-control study we included a cohort of 89 patients with type 2 DM, aged 40 or above, between Jan 1, 2017 and March 31, 2017. Read More

    Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma.
    BMC Cancer 2018 Apr 18;18(1):439. Epub 2018 Apr 18.
    Department of Surgical Sciences, University of Turin, Via Nizza 230, 10126, Turin, Italy.
    Background: Several studies in the past have investigated the expression of micro RNAs (miRNAs) in saliva as potential biomarkers. Since miRNAs associated with extracellular vesicles (EVs) are known to be protected from enzymatic degradation, we evaluated whether salivary EVs from patients with oral squamous cell carcinoma (OSCC) were enriched with specific subsets of miRNAs.

    Methods: OSCC patients and controls were matched with regards to age, gender and risk factors. Read More

    Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway.
    Cell Physiol Biochem 2018 Apr 13;46(3):1009-1018. Epub 2018 Apr 13.
    Background/aims: Many clinical and experimental studies have shown that treatment with statins could prevent myocardial hypertrophy and remodeling induced by hypertension and myocardial infarction. But the molecular mechanism was not clear. We aimed to investigate the beneficial effects of atorvastatin on hypertension-induced myocardial hypertrophy and remodeling in spontaneously hypertensive rats (SHR) with the hope of revealing other potential mechanisms or target pathways to interpret the pleiotropic effects of atorvastatin on myocardial hypertrophy. Read More

    Brain abscess caused by chronic invasive actinomycosis in the nasopharynx: A case report and literature review.
    Medicine (Baltimore) 2018 Apr;97(16):e0406
    Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
    Rationale: Actinomycosis is a rare anaerobic, gram-positive bacterial infection caused by Actinomyces, which is part of the normal flora in the oral cavity and respiratory and female genitourinary tracts. The cervicofacial area is the most common site of involvement, and involvement of the central nervous system is rare.

    Patient Concerns: We report a case involving a 51-year-old woman who developed an actinomycotic brain abscess 15 months after the treatment of noninvasive nasopharyngeal actinomycosis, which recurred as an invasive form. Read More

    A delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia with a mutant of RYR2 at c.7580T>G for 6 years in a 9-year-old child.
    Medicine (Baltimore) 2018 Apr;97(16):e0368
    Department of Pediatrics, West China Second University Hospital, Sichuan University.
    Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but potentially lethal inherited arrhythmia syndrome induced by adrenergic stress. Due to the atypical clinical manifestations in early age, limited recognition and experience of pediatric cardiologists, and low awareness of the significance of genetic diagnosis in some underdeveloped areas in China, a delayed or missed diagnosis of CPVT in children is common and concerning.

    Patient Concerns: A 9-year and 3-month male child with recurrent exercise-induced syncope accompanied by convulsion was initially misdiagnosed as epilepsy since the first manifestation at the age of 3 years. Read More

    Bilateral visual loss and cerebral infarction after spleen embolization in a trauma patient with idiopathic thrombocytopenic purpura: A case report.
    Medicine (Baltimore) 2018 Apr;97(16):e0332
    Department of Anesthesiology, Chi Mei Medical Center, Tainan.
    Rationale: Splenic artery embolization (SAE) is a common procedure in trauma patients with blunt splenic injuries. We report a case of acute ischemic stroke following orthopedic surgery in a patient with post-SAE reactive thrombocytosis.

    Patient Concerns: A 37-year-old woman with idiopathic thrombocytopenic purpura (ITP) suffered from multiple trauma scheduled for open reduction and internal fixation for right tibial and left radius fracture five days after SAE. Read More

    Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.
    Medicine (Baltimore) 2018 Apr;97(16):e0329
    Department of Public Health and Infectious Diseases.
    Introduction: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity. Read More

    The 6th Rare Disease South Eastern Europe (See) Meeting, Skopje, Macedonia (November 11th, 2017).
    Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):163-168
    Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia.
    The sixth SEE meeting on rare diseases (RDs) was held in MASA the November 10th, 2017. A block of lectures on rare renal diseases started the meeting: nephrotic syndrome, Alport syndrome, atypical HUS, hypophosphatemic rickets, CAKUT were presented in all complexities. Their molecular and genetic mechanisms were discussed. Read More

    Magnitude of cone beam computed tomography image artifacts related to zirconium and titanium implants: impact on image quality.
    Dentomaxillofac Radiol 2018 Apr 18:20180021. Epub 2018 Apr 18.
    1 Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas , Piracicaba, São Paulo , Brazil.
    Objectives: To evaluate the magnitude of artifacts related to titanium and zirconium implants at different distances and angulations and their impact on cone beam computed tomography (CBCT) image quality.

    Methods: CBCT images were obtained before and after the insertion of titanium and zirconium implants in a mandible on different CBCT units: Picasso Trio, ProMax 3D and 3D Accuitomo 80. Artefact was assessed by measuring the standard deviation of gray values (SD) and contrast-to-noise ratio (CNR) of 11 regions of interest (ROI) at different distances (1. Read More

    Social inequality in cancer survivors' health behaviours-A Danish population-based study.
    Eur J Cancer Care (Engl) 2018 Apr 18:e12840. Epub 2018 Apr 18.
    DEFACTUM, Central Denmark Region, Aarhus, Denmark.
    The aim of this study was to compare health behaviours (smoking, alcohol consumption, physical activity and diet), to explore social inequality in these behaviours among cancer survivors and individuals with no history of cancer, respectively, and to study the impact of time since diagnosis on cancer survivors' health behaviours. Data from the Danish National Health Survey from 2013 were linked with data from the Danish Cancer Registry to identify all cancer diagnoses among the respondents during the period 1945-2012. In total, 11,166 cancer survivors and 151,117 individuals with no history of cancer were included. Read More

    Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis.
    Oral Dis 2018 Apr 18. Epub 2018 Apr 18.
    College of Stomatology, Chongqing Medical University, Chongqing, China.
    Amyloidosis is a rare metabolic disorder caused by the extracellular deposition of fibrillar proteins in important organs. The prognosis of oral amyloidosis associated with systemic involvement is generally poor, but is much more favourable in localized cases. Limited information is available regarding the differential diagnosis between localized and systemic amyloidosis involving the oral mucosa, and also the prognosis. Read More

    A case of Behçet's disease with various gastrointestinal findings.
    Clin J Gastroenterol 2018 Apr 17. Epub 2018 Apr 17.
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-Dori, Chuo-Ku, Niigata, 9518510, Japan.
    Behçet's disease (BD) is a systemic inflammatory disorder involving the oral and genital mucosa, skin, eyes, gastrointestinal tract, joints, vasculature, and nervous. The gastrointestinal lesions accompanying with BD can extend along the full length of the tract, from the mouth to the anus, and show various clinical characteristics which is difficult to be differentiate from the other inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Hence, the differential diagnosis is difficult and can affect treatment outcomes. Read More

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