30 results match your criteria Oral Brush Biopsy With Computer-Assisted Analysis
Clin Oral Investig 2017 Jun 8;21(5):1631-1637. Epub 2016 Sep 8.
Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Background: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common tumor entity worldwide. Unfortunately, the multimodal treatment consisting of surgery, radiation, and chemotherapy does not show the desired efficacy. The intent of this study was to evaluate the sensitivity and specificity of an oral brush biopsy in combination with glucose transporter (GLUT)-1 staining in identifying premalignant and malignant lesions. Read More
J Evid Based Dent Pract 2016 Jun 14;16(2):113-4. Epub 2016 May 14.
Article Title And Bibliographic Information: Meta-analysis of 2 computer-assisted screening methods for diagnosing oral precancer and cancer. Ye X, Zhang J, Tan Y, Chen G, Zhou G. Oral Oncol 2015;51:966-75. Read More
Evid Based Dent 2015 Dec;16(4):106-7
Department of Dentistry, Illinois Masonic Medical Center, Chicago, Illinois, USA.
Data Sources: The Medline, Embase, PubMed, Elsevier and Web of Science databases and the reference lists of known primary and review papers were scanned for relevant citations.
Study Selection: Prospective and retrospective studies evaluating brush cytology were considered. Only computer-assisted methods that included histologically confirmed disease positive status were included. Read More
Oral Oncol 2015 Nov 5;51(11):966-975. Epub 2015 Oct 5.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan, PR China. Electronic address:
The early diagnosis of oral precancer and cancer is crucial and could have the highest impact on improving survival rates. A meta-analysis was conducted to compare the accuracy between the OralCDx brush biopsy and DNA-image cytometry in diagnosing both conditions. Bibliographic databases were systematically searched for original relevant studies on the early diagnosis of oral precancer and oral cancer. Read More
J Int Oral Health 2015 Mar;7(3):33-8
Post Graduate Student, Guru Nanak Dev Dental College & Research Institute, Sunam, Punjab, India.
Background: In the present study, the reliability of oral brush biopsy in identifying dysplasia in clinically diagnosed oral potentially malignant and malignant lesions was evaluated while comparing the findings with scalpel biopsy in terms of sensitivity and specificity.
Materials And Methods: In our study, a total number of 50 patients that included both premalignant and malignant lesions were included. Oral brush cytology using a cytobrush was done for all patients, which was followed by incisional biopsy. Read More
J Cancer Res Ther 2014 Apr-Jun;10(2):232-8
Department of Oral Medicine and Radiology, Subharti Dental College, Subhartipuram, Meerut, India.
Background: Oral cancer accounts for 5% of all malignant tumors and 60% of these lesions are well advanced at the time of diagnosis. The early diagnosis could prevent a large number of deaths due to this disease.
Aims: This study aims to evaluate and compare the clinical usefulness of exfoliative cytology, modified brush biopsy (without computer assisted analysis), and biopsy in early detection of oral premalignant and malignant lesions. Read More
J Clin Diagn Res 2014 Feb 3;8(2):222-6. Epub 2014 Feb 3.
Faculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland .
Introduction: The Oral CDx® brush biopsy (BB) method is a computer-assisted sample analysis that detects abnormal cells in all cell layers of the epithelium of the oral mucosa.
Method: We took 263 oral BBs from 200 patients with potentially malignant disorders.
Results: We received 204 negative results and 39 atypical, 7 positive and 13 inadequate results. Read More
Am J Orthod Dentofacial Orthop 2013 Nov;144(5):682-90
Affiliate associate professor, Department of Orthodontics, School of Dentistry, University of Washington, Seattle, Wash. Electronic address:
Introduction: The purpose of this investigation was to examine the effect of Tweed edgewise treatment on the expression of mandibular growth in the horizontal direction through maintenance of vertical control.
Methods: We studied 36 patients who had 4 premolars extracted during treatment. Pretreatment, posttreatment, and postretention records of these patients were matched by age (± 6 months), sex, malocclusion, and treatment interval (± 6 months) to untreated controls from the Bolton-Brush Growth Study Center, Cleveland, Ohio. Read More
Int J Dent Hyg 2014 May 12;12(2):89-95. Epub 2013 Jul 12.
Procter & Gamble, Greater London Innovation Center, Reading, UK.
Objective: To compare the plaque inhibition efficacy of a novel stannous-containing sodium fluoride test dentifrice to a standard anticavity negative control dentifrice, when both were used in conjunction with an advanced oscillating-rotating (O/R) power toothbrush.
Methods: This was a randomized, two-treatment, three-period, double-blind crossover study conducted in a population using an O/R power brush. Subjects brushed twice per day with their assigned dentifrice during the three-treatment periods, each lasting for 17 consecutive days. Read More
Oral Oncol 2013 May 11;49(5):420-6. Epub 2013 Jan 11.
Harvard Medical School, Boston, USA.
Objectives: Adjunctive techniques like DNA image cytometry (DNA-ICM) have been attributed to enhance the diagnostic performance of oral brush biopsies. The aim of the study was an evaluation of brush biopsies, analysed according to morphological criteria and by DNA-ICM vs. histological findings in a blinded prospective trial. Read More
J Clin Dent 2012 ;23(3):71-5
Procter & Gamble London Innovation Centre, Egham, Surrey, UK.
Objective: To assess the plaque inhibition efficacy ofa novel 0.454% stabilized stannous fluoride test dentifrice (SnF2) to an amine fluoride/stannous fluoride marketed control dentifrice (AmF/SnF2) using digital plaque imaging analysis (DPIA).
Methods: The 10-week study was a randomized, two-treatment, three-period, double-blind crossover design. Read More
Head Neck Oncol 2011 Aug 24;3:39. Epub 2011 Aug 24.
Department of Pathology, Moti Lal Nehru Medical College, Lowther Road, Allahabad, 211001 India.
Background: Cancer of the oral cavity is the sixth most common malignancy reported worldwide and one with the highest mortality rate among all malignancies. There is a paucity of reliable diagnostic methods to detect early malignancies. This study was performed to evaluate the sensitivity and specificity of brush biopsy in identifying oral premalignant and malignant lesions. Read More
Diagn Cytopathol 2012 Jan 25;40(1):73-83. Epub 2011 Mar 25.
Department of Pathology, Division of Cytopathology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India. com
Historically, sensitivity and specificity of oral cytology is poor. Using conventional oral cytology for the diagnosis of cancer and its precursors has not had the success that cytologists had hoped for; however, with improved methodology, oral cytology has enjoyed a resurgence of interest. This renewed interest is partly due to the introduction of a specialized brush that collects a full-thickness epithelial sample and not just superficially sloughed cells, as well as analysis of that sample with computer assistance; in addition, a variety of adjunctive techniques have been introduced to potentially enhance the diagnosis of the cytologic specimens including DNA analysis, immunocytochemistry, molecular analysis, and liquid-based preparations. Read More
Int J Dent Hyg 2011 Aug 28;9(3):223-8. Epub 2010 Dec 28.
Procter & Gamble, London Innovation Centre, Egham, Surrey, UK.
Objective: While gingivitis and caries continue to be prevalent issues, there is growing concern about dental erosion induced by dietary acids. An oral hygiene product that protects against all these conditions would be beneficial. This study investigated the potential of two anti-erosion dentifrices to inhibit plaque. Read More
J Clin Dent 2011 ;22(5):144-8
Procter & Gamble, London Innovation Centre, Egham, Surrey, UK.
Objective: To compare the plaque inhibition efficacy of a novel 0.454% stannous fluoride (SnF2) test dentifrice with sodium hexametaphosphate and stannous chloride to a chlorhexidine digluconate (0.05%), aluminium lactate (0. Read More
Cancer Prev Res (Phila) 2010 Apr 23;3(4):518-28. Epub 2010 Mar 23.
Departments of Chemistry and Bioengineering, Rice University, 6100 Main St., Houston, TX 77005, USA.
Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic approaches enabling early detection. In this pilot study, we describe a nano-bio-chip (NBC) sensor technique for analysis of oral cancer biomarkers in exfoliative cytology specimens, targeting both biochemical and morphologic changes associated with early oral tumorigenesis. Here, oral lesions from 41 dental patients, along with normal epithelium from 11 healthy volunteers, were sampled using a noninvasive brush biopsy technique. Read More
J Oral Pathol Med 2009 Feb;38(2):161-6
Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India.
During the last decade, oral cytology has once again become the focus of scientific research. This new interest is due to the introduction of a cytobrush for cell collection as well as a computer-assisted analysis (Oral CDx). Although promising, the sensitivity and specificity of conventional oral brush cytology remains limited. Read More
Cancer Invest 2009 Mar;27(3):293-7
Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar, Technische Universitat München, Munich, Germany.
The aim of this study was to evaluate the advantage of computer-assisted analysis of the oral brush biopsy compared with synchronous scalpel biopsy in the early detection of oral lesions. In this prospective, randomized, controlled study, brush and scalpel biopsies were performed on 75 patients. Six patients had to be excluded due to inadequate results, and 43 were shown to have dysplastic epithelium, 15 carcinoma, and 11 suspicious lesions. Read More
Am J Dent 2008 Dec;21(6):346-50
The Procter and Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Purpose: To measure the effectiveness of an oscillating rotating power toothbrush as compared to a manual toothbrush.
Methods: 17 subjects were preliminarily assigned commercial tubes of Crest Cavity Protection (CCP) dentifrice and an Oral-B manual toothbrush (P35) with instructions for bid brushing morning and evening. Subjects remained on CCP dentifrice for 2 weeks during which they were imaged on 6 days (three each week) including daily assessments of morning plaque levels before brushing (AM), morning plaque levels after brushing (PB) and afternoon plaque levels allowing for regrowth (PM). Read More
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 Aug;106(2):246-53
Department of Pathology, Moti Lal Nehru Medical College, University of Allahabad, Allahabad, India.
Objective: The objective of this study was to evaluate the sensitivity and specificity of modified brush biopsy without computer-assisted analysis in the detection of oral premalignant and malignant lesions.
Study Design: Ninety-four patients attending outpatient clinics who exhibited oral lesions suspicious of premalignancy or malignancy were enrolled. All patients underwent an oral brush biopsy using a baby toothbrush followed by a scalpel biopsy. Read More
Mund Kiefer Gesichtschir 2007 Jan;11(1):1-9
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Klinikum der Universität Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Oral cytology has aroused new interest caused by introduction of the cytobrush as a sampling device and the use of additional analytical methods. By brushing it is possible to reach deeper layers of the oral mucosa where squamous intraepithelial neoplasia (SIN) begins. The biological potential of the oral epithelial cells obtained can be evaluated by the following additional methods: computer-assisted image analysis (OralCDx), DNA cytometry, immunohistochemistry, monolayer cytology, and molecular biological analysis. Read More
J Oral Maxillofac Surg 2006 Apr;64(4):628-35
Department of Oral and Maxillofacial Surgery, Baskent University, Adana Teaching and Medical Research Center, Adana, Turkey.
Purpose: Detection of a precancerous or cancerous lesion when small is one of the most important factors to improve 5-year survival rates of oral cancer. Although surgical biopsy is the most definitive method for diagnosing oral lesions, it is impractical to routinely subject large numbers of patients to biopsy. Recently, cytomorphometric assessments improved by advanced computer-assisted image analysis systems have gained importance. Read More
J Clin Dent 2002 ;13(6):225-7
Department of Endodontics and Operative Dentistry, Asahi University School of Dentistry, Gifu, Japan.
The purpose of this in vitro study was to determine how two toothbrushes, with a combination of a tapered-end and round-end bristle design (Group A), compared to a conventional toothbrush with only rounded-end bristles (Group B) for cleaning in simulated occlusal fissures on a brushing machine. The fissure width at the surface was 200 microns, and then tapered down to the fissure base depths of 230 and 400 microns. The toothbrushes were positioned 90 or 180 degrees to the fissure groove surface on the model, and a 200 g force was applied to the brush head. Read More
J Am Dent Assoc 2002 Mar;133(3):357-62
Orlando VA Healthcare Center, Department of Veterans Affaris, FL 32803, USA.
Background: Dentists and dental hygienists attending a health screening program were screened for oral cancer. Select oral epithelial lesions were evaluated by oral brush biopsy with a computer-assisted method of analysis (OralCDx, OralScan Laboratories Inc., Suffern, N. Read More
Compend Contin Educ Dent 2001 Feb;22(2):99-102, 104, 106; quiz 108
Virginia Commonwealth University, Richmond, Virginia, USA.
Computer-assisted analysis of the oral brush biopsy is a recently introduced tool that determines the significance of an oral lesion. The oral brush biopsy is minimally invasive, requires no anesthesia, and definitively distinguishes benign from precancerous and cancerous lesions. Oral brush biopsy specimens are analyzed with the aid of a highly specialized neural network-based computer system specifically designed to detect oral epithelial precancerous and cancerous cells. Read More
Gen Dent 2000 Jan-Feb;48(1):96-9
OralScan Laboratories, Two Executive Boulevard, Suite 102, Suffern, NY 10901-4164, USA.
Awareness about the prevention of oral cancer by both the public and the dental professional is expected to increase significantly. This article provides timely information about the computer-assisted analysis of an oral brush biopsy, a practical and accurate aid to oral cancer screening. Read More
J Clin Periodontol 2000 Apr;27(4):277-83
Department of Periodontology, ACTA, Academic Centre for Dentistry Amsterdam, The Netherlands.
Background/aims: The purpose of the study was to investigate the efficacy of plaque removal by 2 different toothbrushes in a laboratory model and in a clinical study.
Method: The 2 brushes used were the Philips/Jordan HP 735 and the Braun Oral-B Ultra Plaque Remover (D9). Both were compared in a laboratory study (using a robot system) and a short-term clinical study. Read More
J Am Dent Assoc 1999 Oct;130(10):1445-57
Department of Dental Medicine, Long Island Jewish Medical Center, New Hyde Park, N.Y, USA.
Background: A study group composed of researchers from across the United States undertook a study to evaluate the sensitivity and specificity of OralCDx (OralScan Laboratories Inc.), a computer-assisted method of analysis of the oral brush biopsy, in the detection of precancerous and cancerous lesions of the oral mucosa.
Methods: The study group conducted a multicenter double-blind study comparing results of OralCDx analysis with those of scalpel biopsy of suspicious oral lesions, as well as using OralCDx on oral lesions that appeared benign clinically. Read More
J Clin Periodontol 1998 May;25(5):413-6
Department of Periodontology, Academic Centre for Dentistry Amsterdam, ACTA, The Netherlands.
This survey investigated the association between the efficacy of plaque removal and toothbrushing forces during a normal brushing regime. The 94 subjects participating in this study were requested not to brush 24 h prior to the experiment. Panelists brushed for 1 min with a manual toothbrush. Read More
J Clin Periodontol 1994 Nov;21(10):701-4
Department of Preventive Dentistry and Periodontology, School of Dentistry, Aristotle University of Thessaloniki, Greece.
Non-prescription prebrushing rinses to facilitate dental plaque removal have been advertised in recent years. The purpose of the present study was to determine the plaque removal effectiveness of Plax (Colgate) prebrushing rinse by comparing it to a placebo solution. 19 dental students volunteered for this double blind study which consisted of 2 experimental periods. Read More