1,033,232 results match your criteria Oral Brush Biopsy With Computer-Assisted Analysis


Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection.

Cell Physiol Biochem 2018 11;51(5):2377-2396. Epub 2018 Dec 11.

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou,

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. Read More

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December 2018

Tanshinone IIA Inhibits High Glucose-Induced Collagen Synthesis via Nuclear Factor Erythroid 2-Related Factor 2 in Cardiac Fibroblasts.

Cell Physiol Biochem 2018 7;51(5):2250-2261. Epub 2018 Dec 7.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background/aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis. Cardiac fibroblasts have been identified as an important participant in the development of cardiac fibrosis. Exposure of cultured cardiac fibroblasts to high glucose resulted in increased collagen synthesis. Read More

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December 2018

Buccal Fat Pad: Report of 24 Cases and Literature Review of 1,635 Cases of Oral Defect Reconstruction.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):24-35. Epub 2018 Dec 11.

Maxillo-Facial Surgery Unit, Neurosensorial Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objective: The buccal fat pad (BFP) has been progressively introduced into clinical practice for oral defect reconstruction. This study describes our experience with this technique and compares indications in the literature and outcomes.

Methods: We prospectively enrolled 24 patients presenting oral surgical defects and treated between January 2012 and January 2015 at our institution. Read More

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December 2018

Transition of cancer in populations in India.

Cancer Epidemiol 2018 Dec 8;58:111-120. Epub 2018 Dec 8.

Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Background & Objectives: An assessment of transition of cancer in India during the past 30 years, according to changes in demographic and epidemiologic risk factors was undertaken.

Materials & Methods: Cancer registry data (http://www.ncdirindia. Read More

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December 2018

Pseudoginsenoside-F11 attenuates cognitive impairment by ameliorating oxidative stress and neuroinflammation in d‑galactose-treated mice.

Int Immunopharmacol 2018 Dec 8;67:78-86. Epub 2018 Dec 8.

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China. Electronic address:

Oxidative stress and neuroinflammation are thought to be the two key early events during the process of mild cognitive impairment (MCI). Therefore, effective regulation of oxidative stress and neuroinflammation is an important aspect of preventing and improving MCI. We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, markedly reduced cognitive impairment in APP/PS1 mice and oAβ-injected mice. Read More

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December 2018

In vivo transcriptome changes of human white blood cells in response to vitamin D.

J Steroid Biochem Mol Biol 2018 Dec 8. Epub 2018 Dec 8.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

In the vitamin D intervention study VitDbol (NCT02063334) blood samples were drawn directly before an oral bolus (2000 µg vitamin D) and 24 h later. The focus of phase II of VitDbol was the transcriptome-wide analysis of the effects of vitamin D gene expression in human peripheral blood mononuclear cells (PBMCs). All five participants responded in an individual fashion to the bolus by increases in serum levels of the vitamin D metabolites 25-hydroxyvitamin D (25(OH)D) and 1α,25-dihydroxyvitamin D (1,25(OH)D). Read More

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December 2018

Histological and histochemical characterisation of glands associated with the feeding appendages of Argulus foliaceus (Linnaeus, 1758).

Parasitol Int 2018 Dec 8. Epub 2018 Dec 8.

Institute of Aquaculture, University of Stirling, Stirling, UK.

Argulus foliaceus (Linnaeus, 1758) is a member of the branchiuran family Argulidae, a group comprising parasitic "fish lice". A. foliaceus is distributed worldwide and causes major economic impacts for cultured freshwater fish globally. Read More

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December 2018

Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of α-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan. Electronic address:

A sulfated polysaccharide ascophyllan inhibited α-glucosidase in a concentration dependent manner, and >90% activity was inhibited at 1.0 mg/mL. The inhibitory activity was much higher than that of acarbose. Read More

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December 2018

Promotion of skin wound healing using prevascularized oral mucosal cell sheet.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: This study examined the potential use of our newly developed prevascularized oral mucosal cell sheet for the treatment of skin wounds.

Methods: Mucosal cell sheets containing cultured keratinocytes and plasma fibrin without (K sheet) or with a mixture of fibroblasts and endothelial progenitor cells (PV sheet) were transplanted into full-thickness skin excisional wounds of nude mice.

Results: This technique was successful for in vitro culture; expanding keratinocytes, fibroblasts, and endothelial progenitor cells; and generating prevascularized mucosal cell sheets. Read More

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December 2018
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Prognostic performance of the American Joint Committee on Cancer 8th edition of the TNM staging system in patients with early oral tongue cancer.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Departments of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Background: The 8th edition of the American Joint Committee on Cancer's (AJCC) staging system for oral cavity cancer incorporates pathological features. We aimed to assess whether these changes results in better risk stratification of patients with early oral tongue squamous cell carcinoma (OTSCC).

Methods: Overall survival (OS) and disease-specific survival (DSS) of 244 patients were calculated using the Kaplan-Meier method. Read More

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December 2018

Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival.

Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. Read More

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December 2018

Microneedle-Mediated Vaccine Delivery to the Oral Mucosa.

Adv Healthc Mater 2018 Dec 10:e1801180. Epub 2018 Dec 10.

Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.

The oral mucosa is a minimally invasive and immunologically rich site that is underutilized for vaccination due to physiological and immunological barriers. To develop effective oral mucosal vaccines, key questions regarding vaccine residence time, uptake, adjuvant formulation, dose, and delivery location must be answered. However, currently available dosage forms are insufficient to address all these questions. Read More

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December 2018

Improved resin-to-dentin bond strength and durability via non-thermal atmospheric pressure plasma drying of etched dentin.

Eur J Oral Sci 2018 Dec 9. Epub 2018 Dec 9.

Department of Health Policy and Management, College of Health Science, Seoul, Korea.

This study aimed to evaluate the improvement in strength and durability of the bond between dentin and composite resins following plasma drying of the etched dentin surface using non-thermal atmospheric pressure plasma. Plasma drying was applied to the etched dentin before applying adhesive. Conventional wet-bonding and helium (He) gas-dried bonding schemes were used as control groups. Read More

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December 2018

Major bleeding with antithrombotic agents: a 2012-2015 study using the French nationwide Health Insurance Database (SNIIRAM) linked to emergency departments records within five areas. Rationale and design of SACHA study.

Fundam Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

CHU de Brest, F-29200, France.

Bleeding represents the most recognised and feared complications of antithrombotic drugs including oral anticoagulants. Previous studies showed inconsistent results on the safety profile. Among explanations, bleeding definition could vary and classification bias exist related to the lack of medical evaluation. Read More

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December 2018

Original vs. non-original abutments for screw-retained single implant crowns: An in vitro evaluation of internal fit, mechanical behaviour and screw loosening.

Clin Oral Implants Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Buccofacial Prosthesis, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.

Objectives: To assess the internal accuracy, mechanical behaviour under static load and screw loosening before and after cyclic loading of implant-supported crowns restored with original components or with two compatible non-original brands.

Materials And Methods: Sixty-three dental implants were divided into three groups (n = 21 each): Group 1 used original components, and groups 2 and 3 used non-original components. Internal accuracy was measured throughout a cross section of the sample groups (n = 8) using scanning electron microscopy (SEM) to evaluate the fit for implant-abutments, implant-crowns and crown-abutments. Read More

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November 2018
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Serum cotinine, vitamin D exposure levels and dental caries experience in U.S. adolescents.

Community Dent Oral Epidemiol 2018 Dec 10. Epub 2018 Dec 10.

Oral Health Services Research Core, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia.

Introduction: Epidemiologic studies of risk and protective factors for poor oral health have mostly been among children and adults, seldom focusing on adolescents. The aims of this study were to examine whether serum cotinine, a marker of tobacco exposure, and serum vitamin D are independently associated with dental caries experience among adolescents.

Methods: Cross-sectional data from 2579 adolescent participants in the 2005-2008 National Health and Nutritional Examination Survey were analysed. Read More

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December 2018

An in vitro assessment for evaluating the efficiency of β-d-mannuronic acid (M2000) in myelodysplastic syndrome.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

β-d-Mannuronic acid (M2000), a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties, has been previously shown to exhibit potential therapeutic effects on autoimmune diseases. Immunosuppression therapy has been a standard approach for myelodysplastic syndrome (MDS) for many years. We evaluated the effect of M2000 on isolated peripheral blood mononuclear cells (PBMCs) from patients with MDS. Read More

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December 2018

Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

School of Dentistry, National Defense Medical Center, Taipei, Taiwan.

Background: Aberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human cancers. The aim of this study was to assess DcR3 as a target of the anticancer effects of triptolide (TPL) in preclinical patient-derived tumor xenograft (PDTX) models of oral squamous cell carcinoma (OSCC).

Methods: The expression of DcR3 was evaluated through immunohistochemistry, and correlations were examined using clinical variables. Read More

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December 2018

Determinants of emergency department utilization for non-traumatic dental conditions in Massachusetts.

J Public Health Dent 2018 Dec 10. Epub 2018 Dec 10.

Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.

Objectives: To study the determinants of emergency department (ED) utilization for non-traumatic dental conditions (NTDCs) by adults in Massachusetts.

Methods: We analyzed patient-level factors associated with ED utilization for NTDCs in Massachusetts during 2013, using the Massachusetts All Payer Claims Dataset. The primary independent variables of interest were use of preventive dental service in the year preceding the ED visit and dental insurance coverage. Read More

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December 2018

Outcomes of maxillary sinus floor augmentation without grafts in atrophic maxilla: a systematic review and meta-analysis based on randomized controlled trials.

J Oral Rehabil 2018 Dec 11. Epub 2018 Dec 11.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedical Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu road, Wuhan, 430079, People's Republic of China.

Background: Maxillary sinus floor augmentation without grafts has been more widely used, but the efficacy is still controversial.

Purpose: The aim of this review was to systematically evaluate the effectiveness of sinus floor augmentation without grafts in atrophic maxilla.

Methods: The electronic databases included PubMed, EMBASE and the Cochrane Central Register of Controlled Trials. Read More

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December 2018

Acute cellular rejection treatment outcomes stratified by Banff grade in pediatric kidney transplant.

Pediatr Transplant 2018 Dec 7:e13334. Epub 2018 Dec 7.

Pediatric Nephrology at Children's Healthcare of Atlanta, Atlanta, Georgia.

Introduction: There are limited data to guide optimal treatment strategies for acute cellular rejection (ACR) based on Banff grade for pediatric kidney transplant recipients. This report reviews a large pediatric transplant center's experience with ACR.

Materials And Methods: A retrospective analysis of pediatric kidney transplant recipients at our center from 2007 to 2014 was performed. Read More

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December 2018

Developmental defects of enamel in the deciduous incisors of infants born preterm: prospective cohort.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Oral Health, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Objective: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants.

Subjects And Methods: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Read More

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December 2018

Cytogenetic Biomonitoring of Dental Technicians: A Cross-Sectional Study.

J Prosthodont 2018 Dec 7. Epub 2018 Dec 7.

Division for Mutagenesis, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Purpose: This is a cross-sectional study to assess the incidence of micronuclei and other nuclear morphological changes in buccal epithelial cells of dental technicians.

Materials And Methods: The study was conducted on 45 dental technicians vs. 2 control groups: 50 dentists and 50 dental assistants. Read More

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December 2018

Differential regulation of intestinal and hepatic CYP3A by 1α,25-dihydroxyvitamin D : Effects on in vivo oral absorption and disposition of buspirone in rats.

Drug Dev Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan, South Korea.

1α,25-Dihydroxyvitamin D (also called 1,25(OH) D or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CYP3A) expression was altered by 1,25(OH) D -mediated VDR activation. However, to clarify whether the change in CYP3A subfamily expression by VDR activation can affect metabolic function, further evidence is needed to prove the effect of 1,25(OH) D treatment on CYP3A-mediated drug metabolism and pharmacokinetics. Read More

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December 2018

Post-diagnosis aspirin use and survival in veterans with head and neck cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.

Background: Our objective was to determine the effect of post-diagnosis aspirin use on survival in veterans with head and neck squamous cell carcinoma.

Methods: Retrospective cohort study of 584 veterans with head and neck squamous cell carcinoma treated at the Washington DC VA Medical Center between 1995 and 2015. Charts were queried for clinical-pathologic data, aspirin prescriptions, and outcome. Read More

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December 2018

Delivery of Preventive Oral Health Services by Rurality: A Cross-Sectional Analysis.

J Rural Health 2018 Dec 7. Epub 2018 Dec 7.

RAND Corporation, Pittsburgh, Pennsylvania.

Purpose: Integrating oral health care into primary care has been promoted as a strategy to increase delivery of preventive oral health services (POHS) to young children, particularly in rural areas where few dentists practice. Using a multistate sample of Medicaid claims, we examined a child's odds of receiving POHS in a medical office by county rurality.

Methods: We used 2012-2014 Medicaid Analytic extract claims data for 6,275,456 children younger than 6 years in 39 states that allowed Medicaid payment for POHS in medical offices. Read More

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December 2018

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

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December 2018
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Population Pharmacokinetics and Bayesian Estimation of Mycophenolic Acid Exposure in Chinese Renal Allograft Recipients After Administration of EC-MPS.

J Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Organ Transplantation Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The aim of the present study is to establish a population pharmacokinetic (PPK) model of mycophenolic acid (MPA) and limited sampling strategy models for the estimation of MPA exposure in Chinese adult renal allograft recipients following oral administration of enteric coated mycophenolate sodium (EC-MPS). A total of 74 sets of full pharmacokinetic profiles and 47 sets of MPA-sparing samples were collected from 102 renal transplant recipients who received oral EC-MPS. The MPA concentration was determined by an enzyme-multiplied immunoassay technique, and the pathophysiologic data were recorded. Read More

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December 2018

Acute Toxoplasma gondii infection alters the number of neurons and the proportion of enteric glial cells in the duodenum in Wistar rats.

Neurogastroenterol Motil 2018 Dec 10:e13523. Epub 2018 Dec 10.

Universidade Estadual de Maringá, Maringá, Brazil.

Background: Toxoplasma gondii infection can occur through the ingestion of raw meat that contains tissue cysts or food that contains oocysts. Through the ingestion of oocysts, the parasite crosses the intestinal barrier, where the enteric nervous system is located. The objective was to investigate the kinetics of neuronal and glial responses during acute T. Read More

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December 2018

Food Effect Study Design With Oral Drugs: Lessons Learned From Recently Approved Drugs in Oncology.

J Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA.

Evaluation of the effect of food on the pharmacokinetics of oral oncology drugs is critical to drug development, as food can mitigate or exacerbate toxicities and alter systemic exposure. Our aim is to expand on current US Food and Drug Administration (FDA) guidance and provide data-driven food-effect study design recommendations specific to the oncology therapeutic area. Data for recently approved small-molecule oncology drugs was extracted from the clinical pharmacology review in the sponsor's FDA submission package. Read More

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December 2018
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The relationship between oral-health-related quality of life and general health in an elderly population: A cross-sectional study.

Gerodontology 2018 Dec 7. Epub 2018 Dec 7.

Epidemiology and Public Health, University College Cork, Cork, Ireland.

Objective: To assess the oral-health-related quality of life (OHRQoL) in a cohort of Irish older patients and explore associations with overall health status.

Background: The impact of oral health conditions on older individuals' quality of life may be influenced by patients' general health status.

Materials And Methods: This paper reports a cross-sectional study, which analysed baseline data from patients aged over 60 years. Read More

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December 2018

Functional fat injection under local anesthesia to treat severe postsurgical dysphagia, a case report.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences and Community Health, Division of Otorhinolaryngology, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Milan, Italy.

Background: In this study, we present the first application of functional fat injection performed under local anesthesia in the treatment of severe dysphagia secondary to head and neck cancer surgery.

Methods: Functional fat injection was performed using a transcervical approach. Control of injection depth and site was performed through a transnasal flexible endoscope. Read More

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December 2018

Mechanical loading releases osteoclastogenesis-modulating factors through stimulation of the P2X7 receptor in hematopoietic progenitor cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden.

Mechanical instability of bone implants stimulate osteoclast differentiation and peri-implant bone loss, leading to prosthetic loosening. It is unclear which cells at the periprosthetic interface transduce mechanical signals into a biochemical response, and subsequently facilitate bone loss. We hypothesized that mechanical overloading of hematopoietic bone marrow progenitor cells, which are located near to the inserted bone implants, stimulates the release of osteoclast-inducing soluble factors. Read More

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December 2018

Evaluation of long-term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Finasteride 1 mg is considered to be the standard treatment method for male androgenetic alopecia (AGA). However, there have only been a few studies investigating its long-term efficacy. Moreover, its effect on various types of AGA remains unknown. Read More

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December 2018

Case of hand, foot and mouth disease with vesicular Koebner phenomenon on the ankles caused by Coxsackievirus A6 in an adult.

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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December 2018

Local injection of RANKL facilitates tooth movement and alveolar bone remodeling.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Korea.

Objectives: To investigate the effect of local injection of receptor activator of nuclear factor kappa B ligand (RANKL) on experimental tooth movement and subsequent alveolar bone remodeling in mice.

Materials And Methods: Sixty mice were randomised to receive daily local RANKL or phosphate-buffered saline injections in the buccal premaxillary bone for 14 of 21 days of incisor movement, followed by a 21-day retention period. Five mice from each group were euthanised on days 0, 3, 7, 14, 21, and 42, and specimens were prepared for haematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemical staining. Read More

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December 2018

Postoperative pain after glide path preparation using manual, reciprocating and continuous rotary instruments: a randomized clinical trial.

Int Endod J 2018 Dec 8. Epub 2018 Dec 8.

Miadent Oral and Dental Health Center, Ankara, Turkey.

Aim: to compare the incidence, intensity and prediction of postoperative pain after glide path preparation with manual, continuous rotary and a novel reciprocating glide path instrument.

Methodology: The study included 240 patients, which were treated by 4 specialists according to a planned treatment protocol. Following access cavity preparation and prior to glide path preparation, the subjects were randomly assigned to 1 of the 3 groups according to the glide path instrument by choosing a sealed envelope containing the group name: R-Pilot (VDW, Munich, Germany), ProGlider (Dentsply Sirona, Ballaigues, Switzerland) and stainless-steel K-files (Dentsply Sirona) (n = 80). Read More

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December 2018

Differential Mucosal Gene Expression Patterns in Candida-Associated, Chronic Oral Denture Stomatitis.

J Prosthodont 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY.

Purpose: Denture stomatitis is a common condition manifested by inflammation of the oral mucous membrane beneath a denture. The objective of this study was to compare the transcriptome of human palatal mucosa with chronic oral stomatitis-associated Candida albicans infection to that of healthy oral mucosa.

Materials And Methods: Oral palatal biopsies were obtained from 17 healthy and 15 C. Read More

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December 2018

Single-Dose Pharmacokinetic Properties and Relative Bioavailability of Different Formulations of Posaconazole Oral Suspension in Healthy Volunteers.

Clin Pharmacol Drug Dev 2018 Dec 10. Epub 2018 Dec 10.

University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb, Croatia.

The rate and extent of absorption of drugs belonging to Biopharmaceutics Classification System class II are rate-limited by dissolution and highly dependent on the performance of the formulated product. The purpose of the present study was to investigate the potential impact of a surfactant and the particle size of the active substance on the in vitro drug dissolution profiles and in vivo pharmacokinetics of the poorly soluble drug posaconazole. A comparative physicochemical evaluation was conducted, and 3 formulations of posaconazole oral suspension were tested in various dissolution media compared with the reference product. Read More

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December 2018

Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy.

Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread.

Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Read More

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December 2018

Ultra high performance liquid chromatography with tandem mass spectrometry method for determination of four compounds in rat plasma after oral administration of Xanthii fructus and stir-fried Xanthii fructus extracts.

Biomed Chromatogr 2018 Dec 9:e4464. Epub 2018 Dec 9.

Engineering Center of State Ministry of Education for Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, China.

Xanthii fructus (XF), the fruit of Xanthium sibiricum Patr. is a traditional Chinese materia medica commonly used to treat allergic rhinitis (AR) and other rhinitis diseases. To uncover the mechanism of stir frying process and its effect on pharmacokinetic behavior of active compounds in model rats, four active compounds including chlorogenic acid, 4-caffeoylquinic acid, 1,5-O-dicaffeoylquinic acid and apigenin were selected based on previous spectrum-effect experiments. Read More

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December 2018

Physical exercise and non-insulin glucose-lowering therapies in the management of Type 2 diabetes mellitus: a clinical review.

Diabet Med 2018 Dec 7. Epub 2018 Dec 7.

Diabetes Research Group, Swansea University, Medical School, Swansea, UK.

In the UK the National Institute of Health and Care Excellence (NICE) advocates intensive lifestyle programmes that attain the levels of daily physical activity set out by the Chief Medical Officer as a first-line strategy for improving the health of people at risk of developing diabetes or reducing the risk of development of Type 2 diabetes. For people with Type 2 diabetes, lifestyle measures complement pharmacological treatments that include both oral and injectable therapies. In line with this, NICE guidelines also support intensification of efforts to improve patient lifestyle along with these glucose-lowering therapies. Read More

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December 2018

Comparison of BMD Changes and Bone Formation Marker Levels 3 Years After Bisphosphonate Discontinuation: FLEX and HORIZON-PFT Extension I Trials.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

An ASBMR task force recommends a drug holiday for certain women treated for ≥5 years with oral alendronate or ≥3 years with intravenous zoledronic acid, with reassessment 2-3 years later. It is not known whether changes in BMD or bone turnover markers differ after oral or intravenous therapy. Our goal was to compare changes in BMD and procollagen type I N propeptide, PINP, after oral or intravenous bisphosphonate use. Read More

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December 2018

Melatonin release by exocytosis in the rat parotid gland.

J Anat 2018 Dec 10. Epub 2018 Dec 10.

Department of Biomedical Sciences, Division of Cytomorphology, University of Cagliari, Cagliari, Italy.

Several beneficial effects on oral health are ascribed to melatonin. Due to its lipophilic nature, non-protein-bound circulating melatonin is usually thought to enter the saliva by passive diffusion through salivary acinar gland cells. Recently, however, using transmission electron microscopy (TEM), melatonin was found in acinar secretory granules of human salivary glands. Read More

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December 2018

Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.

Background: The purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old).

Methods: We performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs.

Results: Young age HNSCCs occurred in 10. Read More

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December 2018

Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists.

J Am Geriatr Soc 2018 Dec 11. Epub 2018 Dec 11.

Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background: Although polypharmacy is associated with a negative clinical outcome in various settings and commonly observed in patients receiving oral anticoagulation therapy, evidence on the relevance for the clinical outcome of anticoagulated patients is currently limited. The aim of the study was to investigate the effect of polypharmacy on the clinical outcomes among patients taking phenprocoumon.

Design: Prospective cohort study. Read More

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December 2018
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Determination of ospemifene in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

Biomed Chromatogr 2018 Dec 7:e4451. Epub 2018 Dec 7.

Department of Chemistry, GITAM University, Hyderabad, India.

A highly sensitive, specific and rapid Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) analytical method has been developed and validated for the determination of ospemifene in human plasma using ospemifene-d as an internal standard. Solid phase extraction (SPE) technique with Phenomenex Strata X-33μM polymeric sorbent cartridges (30 mg/1ml) was used to extract the analytes from the plasma. The chromatographic separation was achieved on Agilent Eclipse XDB-Phenyl, 4. Read More

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December 2018

Look at my pearly white teeth: Exploring adolescents' oral health behavior.

Public Health Nurs 2018 Dec 9. Epub 2018 Dec 9.

College of Health and Human Services, Indiana State University, Terre Haute, Indiana.

Informed by grounded theory, this study explored adolescent oral health behaviors to determine what factors influence them and to develop a substantive theory explaining the social process behind the behaviors identified. Multiple types of data were collected and analyzed simultaneously: demographic and oral health questionnaires, 16 individual interviews, eight small group discussions, field notes, and investigator memoing. Participants were 37 Midwestern adolescents aged 13-18, and most were White or African-American females 14 years of age whose parents had at least a high school education. Read More

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December 2018
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