20,636 results match your criteria Optometry and Vision Science[Journal]
Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.
School of Optometry, Indiana University Bloomington, Bloomington, IN, USA. Electronic address:
SLC4A11 mutations are associated with Fuchs' endothelial corneal dystrophy (FECD), congenital hereditary endothelial dystrophy (CHED) and Harboyan syndrome (endothelial dystrophy with auditory deficiency). Mice with genetically ablated Slc4a11 recapitulate CHED, exhibiting significant corneal edema and altered endothelial morphology. We recently demonstrated that SLC4A11 functions as an NH sensitive, electrogenic H transporter. Read More
J Curr Ophthalmol 2018 Dec 19;30(4):377-380. Epub 2018 Mar 19.
Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Purpose: To report a rare and complicated case of acanthamoeba keratitis (AK) presented with total necrosis and dislodgment of cornea, iris, and crystalline lens with exposure of vitreous hyaloids face.
Methods: Case report of 28-year-old female referred to the Farabi Eye Hospital with a history of known left eye AK since 4 months earlier. She also had a history of soft contact lens wear for two years and topical steroid use before proper diagnosis. Read More
J Curr Ophthalmol 2018 Dec 27;30(4):343-347. Epub 2018 Apr 27.
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Purpose: This study aimed to evaluate two psychophysical contrast sensitivity testing methods in amblyopic patients.
Methods: Thirty-three adults with anisometropic amblyopia participated in this study. Psychophysical contrast sensitivity was measured for both amblyopic and fellow eyes of the participants at 1, 3, and 5 cycles per degree (cpd) spatial frequencies by Freiburg visual acuity and contrast test (FrACT) and Metrovision contrast sensitivity test, which employ sine-wave gratings for measurement of contrast sensitivity. Read More
J Curr Ophthalmol 2018 Dec 6;30(4):326-329. Epub 2018 Sep 6.
Department of Optometry, Iran University of Medical Sciences, Tehran, Iran.
Purpose: To determine the effect of isotretinoin on corneal sensitivity in acne patients.
Methods: Fifty patients (13 men and 37 women) with a mean age of 23.24 ± 3. Read More
J Curr Ophthalmol 2018 Dec 28;30(4):321-325. Epub 2018 Jun 28.
Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Purpose: To evaluate the association between subjective dry eye symptoms and the results of the clinical examinations.
Methods: The study was a clinical-based survey involving 215 first-year students selected consecutively during a regular ocular health examination at the University of Cape Coast Optometry Clinic. The data collection process spanned for a period of four months. Read More
J Pharmacokinet Pharmacodyn 2018 Dec 14. Epub 2018 Dec 14.
Centre for Applied Pharmacokinetic Research, Division of Pharmacy & Optometry, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
Regulatory agencies have a strong interest in sensitivity analysis for the evaluation of physiologically-based pharmacokinetic (PBPK) models used in pharmaceutical research and drug development and regulatory submissions. One of the applications of PBPK is the prediction of fraction absorbed and bioavailability for drugs following oral administration. In this context, we performed a variance based global sensitivity analysis (GSA) on in-house PBPK models for drug absorption, with the aim of identifying key parameters that influence the predictions of the fraction absorbed and the bioavailability for neutral, acidic and basic compounds. Read More
Biomed Pharmacother 2019 Jan 26;109:1826-1833. Epub 2018 Nov 26.
Department of Optometry, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
Objective: Astragaloside (AST) is a kind of effective components of Astragalus membranaceus, which has been reported to exert extensive pharmacological actions in various diseases. However, the effect of AST on optic nerve injury remains unclear. The study aimed to uncover the effect of AST on oxygen glucose deprivation (OGD)-induced RGC-5 cells injury and the underlying mechanism. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5932-5940
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Purpose: To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT).
Methods: Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Read More
Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.
School of Optometry, Université de Montréal, CP 6128 succursale centre-ville, Montreal, Quebec, Canada.
Light increments (brights) and decrements (darks) are differently processed throughout the early visual system. It is well known that a bias towards faster and stronger responses to darks is present in the retina, lateral geniculate nucleus and primary visual cortex. In humans, psychophysical and neurophysiological data indicate that darks are better detected than brights, suggesting that the dark bias found in early visual areas is transmitted across the cortical hierarchy. Read More
Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology and Optometry, Vienna Trial Center (VTC), Medical University of Vienna, Vienna, Austria.
Purpose: Quantification of fundus autofluorescence has only recently become available. We report our findings on the evaluation of the repeatability and reliability of quantitative fundus autofluorescence (qAF) measurements in patients with early and intermediate age-related macular degeneration (AMD), using the first approved and commercially available instrument.
Methods: A total of 43 eyes of 22 patients (aged between 52 and 84 years) diagnosed with early and intermediate AMD were included. Read More
Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong.
Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. Read More
Cont Lens Anterior Eye 2018 Dec 11. Epub 2018 Dec 11.
Department of Biotechnology and Biosciences, University of Milano - Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy; Optic and Optometry Center of the University of Milano - Bicocca (COMiB), Italy.
Lactoferrin (LF), an iron-binding protein with antioxidant activity, is significantly reduced in the lacrimal film of patients affected by keratoconus (KC) compared to healthy subjects, and this is supposed to be the cause for tear iron increase and consequent iron deposition and oxygen free radical accumulation in the cornea. We decided to study if LF-loaded contact lenses (LF-CLs) could exert antioxidant activity on epithelial cells incubated in tears collected from two patients affected by keratoconus (KC1 and KC2). Moreover through this model we indirectly estimated iron concentration in the tears of healthy and KC subjects. Read More
Cont Lens Anterior Eye 2018 Dec 10. Epub 2018 Dec 10.
Clinical Research Center, School of Optometry, University of California, Berkeley, United States; Vision Science Graduate Program, University of California, Berkeley, United States. Electronic address:
Purpose: To evaluate post-lens tear dynamics at two different time points during scleral lens wear in two cohorts with 10 neophytes each.
Methods: All subjects wore bilaterally scleral lenses for 5 h on 3 separate visits. Post-lens tear exchange was measured using Out-in method, which required 5 μL of 2% FITC-Dextran instilled on the bulbar conjunctiva during lens wear. Read More
PLoS One 2018 13;13(12):e0209004. Epub 2018 Dec 13.
School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.
Today's students have increased expectations for flexible learning options and evidence-based practice resources to be available to support curricular activities. We investigated: (i) the suitability of a static website for teaching ocular anatomy and physiology and an interactive version of the website with quiz and self-assessment activities and (ii) the usefulness of a blended online and in-lab environment to teach in Optometry. We administered a survey to compare responses of optometry students who had access to the interactive website, with those from students from a previous year who used the static version. Read More
N Z Med J 2018 Dec 14;131(1487):80-85. Epub 2018 Dec 14.
Ophthalmologist, Gisborne; Senior Lecturer, Dept of Ophthalmology, University of Otago.
Myopia is an eye condition that is increasing around the world, reaching epidemic levels in many countries. It is associated with a higher risk of other ocular diseases including myopic maculopathy and retinal detachment. Historically in New Zealand myopia has existed at a low level, however the environmental changes that have increased myopia internationally will affect New Zealanders too. Read More
Cancer Nurs 2018 Dec 12. Epub 2018 Dec 12.
Author Affiliations: Schools of Nursing (Drs Lam and Chan) and Optometry (Dr Wong), The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
Background: Nurse-patient communication is of the utmost importance to oncology patients.
Objective: The aim of this study was to investigate the factors influencing the level of satisfaction with nurse-patient communication among oncology patients during their daily routine procedures.
Methods: In this observational study, 25 registered nurses and 94 patients were recruited from an oncology unit. Read More
JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
The Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts.
Importance: To facilitate drug and device development for neonates, the International Neonatal Consortium brings together key stakeholders, including pharmaceutical companies, practitioners, regulators, funding agencies, scientists, and families, to address the need for objective, standardized clinical trial outcome measurements to fulfill regulatory requirements. Retinopathy of prematurity (ROP) is a disease that affects preterm neonates. The current International Classification of Retinopathy of Prematurity does not take into account all of the characteristics of ROP and does not adequately discriminate small changes in disease after treatment. Read More
Curr Gene Ther 2018 Dec 13. Epub 2018 Dec 13.
Tianjin Medical University Eye Hospital, The College of Optometry, Tianjin 300384. China.
Background: As one of the main blinding ocular diseases, corneal blindness results from neovascularization that disrupts the angiogenic privilege of corneal avascularity. Following neovascularization, inflammatory cells are infiltrating into corneal to strengthen corneal injury. How to maintain corneal angiogenic privilege to treat corneal disease has been investigated for decades. Read More
Exp Brain Res 2018 Dec 12. Epub 2018 Dec 12.
NeuroMI-Milan Center for Neuroscience, Milano, Italy.
Prosopagnosia is a disorder leading to difficulties in recognizing faces. However, recent evidence suggests that individuals with congenital prosopagnosia can achieve considerable accuracy when they have to recognize their own faces (self-face advantage). Yet, whether this advantage is face-specific or not is still unclear. Read More
Front Neurol 2018 27;9:1000. Epub 2018 Nov 27.
Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, United States.
Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment. The goal of this study was to develop and validate a targeted ipRGC immunotoxin to ultimately examine the role of ipRGCs in macaque monkeys. An immunotoxin for the macaque melanopsin gene (), consisting of a saporin-conjugated antibody directed at the N-terminus, was prepared in solutions of 0. Read More
J Ophthalmol 2018 6;2018:3470731. Epub 2018 Nov 6.
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Purpose: To evaluate logical surgical approaches to closing macular holes in eyes with proliferative diabetic retinopathy with retinal detachment.
Methods: Retrospective, interventional case series.
Results: 10 eyes in 10 patients were included in this study. Read More
Oxid Med Cell Longev 2018 7;2018:4814928. Epub 2018 Nov 7.
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
The medicinal herb fruit has been widely used for improving and maintaining the health of the eyes in the Far East for many centuries. This study is aimed at investigating whether protective effects generated from the aqueous (LBA) and ethanol (LBE) extracts of the fruit existed against oxidative stress-induced apoptosis in human retinal pigment epithelial cells. extracts LBA and LBE exerted the activity of ROS scavenging and rescued UVB irradiation-induced growth inhibition in retinal pigment epithelial ARPE-19 cells. Read More
Neuroophthalmology 2018 Dec 19;42(6):391-398. Epub 2018 Jun 19.
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
A 62-year-old male with a history of metastatic clear cell renal cell carcinoma (ccRCC) presented with decreased vision to 20/50 in the left eye. Fundus examination revealed an elevated, amelanotic mass lesion in the superotemporal macula, without involvement of the central macula by subretinal fluid or tumour. Given incongruity between the fundus findings and the degree of visual impairment, visual field testing was obtained, revealing a bitemporal hemianopia. Read More
Front Endocrinol (Lausanne) 2018 22;9:670. Epub 2018 Nov 22.
Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
This study was undertaken to determine if crosstalk among the transient receptor potential (TRP) melastatin 8 (TRPM8), TRP vanilloid 1 (TRPV1), and vascular endothelial growth factor (VEGF) receptor triad modulates VEGF-induced Ca signaling in human corneal keratocytes. Using RT-PCR, qPCR and immunohistochemistry, we determined TRPV1 and TRPM8 gene and protein coexpression in a human corneal keratocyte cell line (HCK) and human corneal cross sections. Fluorescence Ca imaging using both a photomultiplier and a single cell digital imaging system as well as planar patch-clamping measured relative intracellular Ca levels and underlying whole-cell currents. Read More
J Neural Eng 2018 Nov 13. Epub 2018 Nov 13.
Department of Biomedical Engineering, University of Melbourne, Parkville, Victoria, AUSTRALIA.
Objective: Retinal prostheses provide visual perception via electrical stimulation of the retina using an implanted array of electrodes. The retinal activation resulting from each electrode is not point-like; instead each electrode introduces a spread of retinal activation that may overlap with activations from other electrodes. With most conventional stimulation strategies this overlap leads to image blur. Read More
J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.
Johns Hopkins Wilmer Eye Institute, Maryland USA.
In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Read More
DNA Cell Biol 2018 Dec 12. Epub 2018 Dec 12.
1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University , Wenzhou, Zhejiang, China .
Acute anterior uveitis (AAU) is an ordinary type of uveitis, which is an autoimmune disease produced by T cells. Programmed apoptosis protein 1 (PD-1) is a vital negative regulatory protein of immune tolerance. We detect the single nucleotide polymorphisms (SNPs) rs41386349, rs10204525, and rs2227982 of PD-1 to investigate the correlation between PD-1 polymorphisms and AAU. Read More
Clin Ophthalmol 2018 19;12:2369-2375. Epub 2018 Nov 19.
Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada,
The assessment of corneal staining is a commonly conducted procedure in both clinical practice and as part of various research studies. Different grading scales are employed by many clinicians and researchers to undertake this procedure for corneal staining comparisons between eyes, products and over time. This paper describes the development and use of a grading scale for corneal staining undertaken at an academic research site. Read More
Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.
Centre for Ocular Research and Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
Purpose: Contact lens (CL) dropout is estimated to be approximately equal to the number of new wearers per year, resulting in virtually no growth in the global CL market. The purpose of this study was to determine ocular and CL factors associated with CL dropout.
Methods: This five-site study recruited subjects 18-45 years of age who had ceased CL wear within the past 6-12 months due to discomfort. Read More
Chemosphere 2018 Dec 3;219:191-201. Epub 2018 Dec 3.
School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, AB10 7GJ, UK. Electronic address:
Households in rural locations utilize septic tanks for wastewater treatment and can cause surface water contamination. A new methodology was developed to help investigate the role septic tanks play in the dissemination of prescription and over-the-counter drugs, personal care products and stimulants in the aqueous environment. Simultaneous analysis of 16 chiral and achiral anthropogenic markers was achieved using a Chirobiotic V2 enantioselective column in polar ionic mode. Read More
J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.
Department of Biomedical Engineering, School of Medicine, Catholic University of Daegu, Daegu, 42472, South Korea.
The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Read More
J Mol Med (Berl) 2018 Dec 8. Epub 2018 Dec 8.
Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More
Transl Vis Sci Technol 2018 Nov 30;7(6):17. Epub 2018 Nov 30.
School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin, China.
Purpose: We present a new method for analyzing relative corneal refractive power (RCRP) in children undergoing orthokeratology and explore its potential association to effective myopic control.
Methods: A total of 55 children aged 8 to 12 years participated in the study. Axial growth was calculated as the difference in axial length before and 1 year after orthokeratology. Read More
Front Behav Neurosci 2018 23;12:292. Epub 2018 Nov 23.
Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.
Color vision assessment can be done using pseudoisochromatic stimuli, which has a luminance noise to eliminate brightness differences between the target and background of the stimulus. It is not clear the influence of the luminance noise on color discrimination. We investigated the effect of change in the luminance noise limits on color discrimination. Read More
Appl Environ Microbiol 2018 Dec 7. Epub 2018 Dec 7.
Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Stopford Building, The University of Manchester, Manchester, UK
Assessing the risk of resistance associated with biocide exposure commonly involves exposing microorganisms to biocides at concentrations close to the MIC. With the aim of representing exposure to environmental biocide residues, MG1655 was grown for 20 passages in the presence or absence of benzalkonium chloride (BAC) at 100 ng/L and 1000 ng/L (0.0002% and 0. Read More
Colloids Surf B Biointerfaces 2018 Nov 29;175:184-194. Epub 2018 Nov 29.
School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, Zhejiang Province, 325001, PR China; Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, CAS, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:
Porous CaCO microparticles are considered as one of the most popular and effective carriers for protein loading. Most of current studies have centered on elucidating particle formation and enhancing the protein loading efficiency, very few reports on the kinetics, driving forces and factors on protein loading process. Here, we took lysozyme as the basic model protein to investigate the kinetics, driving forces on protein loading and factors controlling loading efficiency into porous Hep/CaCO microparticles by various techniques (protein quantification assay, QCM-D, SEM, BET, Zeta sizer, TGA, CLSM, CD spectrum, bioactive assay). Read More
J Pharmacol Toxicol Methods 2018 Dec 5;95:79-85. Epub 2018 Dec 5.
Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, China; Jacob's Retina Center at Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA 92037-0946, United States. Electronic address:
Filtering with a syringe filter is a common operation in pharmaceutical analysis. Ophthalmic research often has a limited amount of sample and low amount of drug which is vulnerable to filtering membrane adsorption loss but not well recognized in the research community. Current study investigated drug adsorption by 11 types of syringe filters for 4 hydrophobic compounds commonly encountered in transscleral drug delivery. Read More
Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922
Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.
To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More
Ophthalmic Res 2018 Dec 6:1-5. Epub 2018 Dec 6.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu,
Purpose: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR).
Methods: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815
School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.
Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More
MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.
On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More
JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.
Indiana University School of Optometry, Bloomington.
In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue initiated by this report. In 2018, a stakeholder meeting assessed the feasibility of establishing a backbone organization, a national center that can provide technical and resource assistance regarding eye and vision health. Read More
Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.
School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia.
Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.
Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.
Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More
Clin Optom (Auckl) 2018 8;10:119-127. Epub 2018 Nov 8.
DAVICH Optical Chain, Daechi-dong, Gangnam-gu, Seoul, South Korea.
Background: The purpose of this study is to investigate and compare spectacle and contact lens (CL) prescription trends, with an emphasis on astigmatic refractive error prescribing differences for patients who purchase spectacles or CLs in South Korea.
Methods: A retrospective study of patient records of a major optical chain in South Korea was conducted. De-identified data of age, gender, power of prescribed spectacles and/or CLs were extracted from the practice database. Read More
Onco Targets Ther 2018 9;11:7987-7999. Epub 2018 Nov 9.
School of Laboratory Medicine and Life Science, Wenzhou Medical University, Zhejiang, People's Republic of China,
Background: Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal cancer cell lines and its molecular mechanism.
Methods: Lupeol was assessed for its anticancer effect using two human colorectal cancer cell lines: SW480 and HCT116. Read More
Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.
Vitreous Retina Macula Consultants of New York, New York, NY, USA.
Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).
Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More
Optom Vis Sci 2018 Dec;95(12):1162-1165
Optom Vis Sci 2018 Dec;95(12):1087
Editor in Chief Birmingham, AL.
J Mater Sci Mater Med 2018 Nov 30;29(12):182. Epub 2018 Nov 30.
Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia.
3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. Read More