20,868 results match your criteria Optometry Times [Journal]


Proteomic and genomic profiling of pancreatic cancer.

Cell Biol Toxicol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Clinical Sciences Lund, Skåne University Hospital, Lund University, SE-221 85, Lund, Sweden.

Pancreatic cancer remains the most fatal human tumor type. The aggressive tumor biology coupled with the lack of early detection strategies and effective treatment are major reasons for the poor survival rate. Collaborative research efforts have been devoted to understand pancreatic cancer at the molecular level. Read More

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http://dx.doi.org/10.1007/s10565-019-09465-9DOI Listing
February 2019

Refractive correction with multifocal intraocular lenses after radial keratotomy.

Eye (Lond) 2019 Feb 15. Epub 2019 Feb 15.

Optics and Optometry and Vision Sciences Department, Faculty of Physics, University of Valencia, Valencia, Spain.

Purpose: To assess visual and refractive results of multifocal intraocular lens (IOLs) implantation for refractive correction after radial keratotomy (RK).

Methods: In a retrospective non-comparative interventional case series, we analyzed the outcomes of multifocal IOL implantation performed in the context of cataract or refractive lens exchange surgery following RK. A total of 17 eyes from nine patients were included in the study. Read More

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http://dx.doi.org/10.1038/s41433-019-0364-8DOI Listing
February 2019

Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial.

Lancet Oncol 2019 Feb 12. Epub 2019 Feb 12.

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.

Background: Stereotactic ablative body radiotherapy (SABR) is widely used to treat inoperable stage 1 non-small-cell lung cancer (NSCLC), despite the absence of prospective evidence that this type of treatment improves local control or prolongs overall survival compared with standard radiotherapy. We aimed to compare the two treatment techniques.

Methods: We did this multicentre, phase 3, randomised, controlled trial in 11 hospitals in Australia and three hospitals in New Zealand. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30896-9DOI Listing
February 2019

Medicare incentive payments to U.S. ophthalmologists for use of electronic health records: 2011-2016.

Ophthalmology 2019 Feb 12. Epub 2019 Feb 12.

Department of Ophthalmology, University of Washington, Seattle, Washington.

Purpose: To investigate ophthalmologists' rate of attestation to meaningful use (MU) of their electronic health record (EHR) systems in the Medicare EHR Incentive Program and their continuity and success in receiving payments in comparison with other specialties.

Design: Administrative database study.

Participants: Eligible professionals participating in the Medicare EHR Incentive Program. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.030DOI Listing
February 2019

The Effects of Diabetic Duration on Lacrimal Functional Unit in Patients with Type II Diabetes.

J Ophthalmol 2019 10;2019:8127515. Epub 2019 Jan 10.

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University, Tianjin 300384, China.

Purpose: To observe ocular surface changes in Type II diabetic patients with different disease durations and to understand the correlations between clinical parameters and diabetic durations.

Methods: In this cross-sectional, prospective study, 51 healthy controls and 91 patients with Type II diabetes were enrolled. The diabetics were divided into 3 subgroups according to the disease duration, including duration <10 y group, 10 to 20 y group, and ≥21 y group. Read More

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http://dx.doi.org/10.1155/2019/8127515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350560PMC
January 2019

Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects.

J Ophthalmol 2019 15;2019:7419470. Epub 2019 Jan 15.

Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA).

Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. Read More

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http://dx.doi.org/10.1155/2019/7419470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350555PMC
January 2019

Vitreous Hemorrhage in the Setting of a Vascular Loop.

Fed Pract 2018 Jun;35(6):38-39

is a Staff Optometrist at the Manchester VA Medical Center in New Hampshire. is Chief of Optometry, and is Chief of Ophthalmology, both at the Providence VA Medical Center in Rhode Island. Dr. Huang and Dr. Mega are adjunct faculty at New England College of Optometry in Boston, Massachusetts. Dr. Greenberg is Professor of Surgery (Ophthalmology) at Warren Alpert Medical School of Brown University in Providence.

Although uncommon, vascular loops should be kept in the differential diagnosis of vitreous hemorrhage, and patients should seek care if experiencing new floaters or visual loss. Read More

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Unilateral Congenital Nasolacrimal Duct Obstruction, Is It An Amblyogenic Factor?

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):156-160

Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Background/aims: To evaluate the refractive status, axial length, and prevalence of amblyopia among Saudi children with unilateral congenital nasolacrimal duct obstruction (UCNLDO) compared to the unaffected fellow eye.

Methods: A retrospective chart review was performed for children with UCNLDO at two eye institutes in Eastern Saudi Arabia from 2009 to 2015. The outcomes of syringing determined UNCLDO. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_3_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348941PMC
February 2019

Knowledge and Attitude toward Eye Donation among Adults, Northwest Ethiopia: A Community-based, Cross-sectional Study.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):126-130

Department of Optometry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: In developing countries, the leading cause of childhood blindness is corneal scarring. Although the service of corneal transplantation depends on several factors, availability of potential donors is of paramount importance. Attitude of eligible donors is the main factor that affects corneal supply. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_267_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348946PMC
February 2019

The Associations between Toll-Like Receptor 4 Gene Polymorphisms and Hepatitis C Virus Infection: A systematic and meta-analysis.

Biosci Rep 2019 Feb 14. Epub 2019 Feb 14.

Faculty of Optometry, Ramkhamhaeng University, Bangkok, Thailand, Bangkok, Thailand

Background And Objective: The hepatitis C virus (HCV) is able to cause a life-threatening disease relating to lethal hepatocellular carcinoma. Previous, Toll-like receptor polymorphisms were proposed as promising biomarker for HCV-related hepatocellular carcinoma and disease progression. This study aimed to summarize the association of TLR4 polymorphisms and HCV infection through meta-analysis. Read More

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http://dx.doi.org/10.1042/BSR20182470DOI Listing
February 2019

Pullulan-derived nanocomposite hydrogels for wastewater remediation: Synthesis and characterization.

J Colloid Interface Sci 2019 Feb 7;542:253-262. Epub 2019 Feb 7.

School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China. Electronic address:

Polysaccharide is a renewable, biocompatible and biodegradable material that has received considerable attention. In this work, a series of polysaccharide gels were synthesized from the chemical cross-linking of pullulan with diglycerols. The effects of the diglycerol chain length on the performance of the gels were evaluated by XRD, TGA, SEM, rheological testings and swelling measurements. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.02.025DOI Listing
February 2019

Self-perception in Children Aged 3 to 7 Years With Amblyopia and Its Association With Deficits in Vision and Fine Motor Skills.

JAMA Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Importance: Deficits in fine motor skills and slow reading speed have been reported in school-aged children and adults with amblyopia. These deficits were correlated with lower self-perception of athletic and cognitive competence. Although perceived competence and social acceptance are key determinants of developing self-perception in young children, the association of amblyopia with self-perception and the association of altered self-perception with fine motor skills to date have not been reported for young children aged 3 to 7 years. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.7075DOI Listing
February 2019

Immunofluorescence Tomography: High-resolution 3-D reconstruction by serial-sectioning of methacrylate embedded tissues and alignment of 2-D immunofluorescence images.

Sci Rep 2019 Feb 13;9(1):1992. Epub 2019 Feb 13.

European Cancer Stem Cell Research Institute, Cardiff University, Maindy Rd, Cardiff, Wales, United Kingdom.

Immunofluorescence tomography is a high-resolution 3-D reconstruction method based on methacrylate embedding and serial-sectioning, where 2-D images of immuno-stained serial-sections are computationally aligned into image stacks, and the 3-D volume rendered. Butyl-Methyl Methacrylate (BMMA) plastic was adopted as it preserves excellent tissue morphology and can be de-plasticized easily using an organic solvent, which enables immuno-staining of serial-sections without antibody penetration issues over millimeters of 3-D reconstructed tissue (Z-depth). High axial Z-resolution over a large volume was achieved by cutting serial-sections at 2 µm thickness. Read More

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http://dx.doi.org/10.1038/s41598-018-38232-9DOI Listing
February 2019

Aberrant expression of a stabilized β-catenin mutant in keratocytes inhibits mouse corneal epithelial stratification.

Sci Rep 2019 Feb 13;9(1):1919. Epub 2019 Feb 13.

School of Optometry, Indiana University, Bloomington, IN, 47405, USA.

We previously reported that genetic deletion of β-catenin in mouse corneal keratocytes resulted in precocious corneal epithelial stratification. In this study, to strengthen the notion that corneal keratocyte-derived Wnt/β-catenin signaling regulates corneal epithelial stratification during mouse development, we examined the consequence of conditional overexpression of a stabilized β-catenin mutant (Ctnnb1) in corneal keratocytes via a doxycycline (Dox)-inducible compound transgenic mouse strain. Histological analysis showed that conditional overexpression of Ctnnb1 in keratocytes inhibited corneal epithelial stratification during postnatal development. Read More

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http://dx.doi.org/10.1038/s41598-018-36392-2DOI Listing
February 2019

YY1 complex promotes Quaking expression via super-enhancer binding during EMT of hepatocellular carcinoma.

Cancer Res 2019 Feb 13. Epub 2019 Feb 13.

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University.

Quaking (QKI) is an alternative splicing factor that can regulate circRNA formation in the progression of epithelial-mesenchymal transition, but the mechanism remains unclear. High expression of QKI is correlated with short survival time, metastasis, and high clinical stage and pathology grade in hepatocellular carcinoma (HCC). Here we report that transcription of the QKI gene was activated by the Yin-Yang 1 (YY1)/p65/p300 complex, in which YY1 bound to the super-enhancer and promoter of QKI, p65 combined with the promoter, and p300 served as a mediator to maintain the stability of the complex. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2238DOI Listing
February 2019

Perception of Aversive Auditory Stimuli Is Different in Sensory Modulation Disorder and Attention Deficit Hyperactivity Disorder.

Am J Occup Ther 2018 Nov/Dec;72(6):7206205020p1-7206205020p8

Yoram Bonneh, PhD, is Visiting Scientist, Department of Optometry and Vision Science, Bar-Ilan University, Tel Aviv, Israel.

This study examined whether sensory modulation disorder-sensory overresponsivity (SMD-SOR) and attention deficit hyperactivity disorder (ADHD) have a significant effect on the perception of aversive auditory stimuli. Participants were 66 young adult women. The diagnosis of SOR was made using the Sensory Responsiveness Questionnaire, and ADHD was diagnosed by a qualified psychiatrist or neurologist using criteria from the Diagnostic and Statistical Manual of Mental Disorders (4th ed. Read More

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http://dx.doi.org/10.5014/ajot.2018.022327DOI Listing
February 2019

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG).

Methods: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Read More

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http://dx.doi.org/10.1007/s00417-019-04251-zDOI Listing
February 2019

Long-Term Clinical Outcomes after Mix and Match Implantation of Two Multifocal Intraocular Lenses with Different Adds.

J Ophthalmol 2019 14;2019:6789263. Epub 2019 Jan 14.

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and Ophthalmology, No. 251, Fukang Road, Nankai District, Tianjin 300384, China.

Purpose: To compare long-term clinical outcomes between patients with bilateral implantation of +3.0 diopter (D) multifocal intraocular lenses (IOLs) and mix and match implantation of +2.5 D and +3. Read More

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http://dx.doi.org/10.1155/2019/6789263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348908PMC
January 2019

Diabetic macular oedema and diode subthreshold micropulse laser (DIAMONDS): study protocol for a randomised controlled trial.

Trials 2019 Feb 12;20(1):122. Epub 2019 Feb 12.

The Northern Ireland Clinical Trials Unit (NICTU), Belfast, UK.

Background: In the UK, macular laser is the treatment of choice for people with diabetic macular oedema with central retinal subfield thickness (CST) < 400 μm, as per National Institute for Health and Care Excellence guidelines. It remains unclear whether subthreshold micropulse laser is superior and should replace standard threshold laser for the treatment of eligible patients.

Methods: DIAMONDS is a pragmatic, multicentre, allocation-concealed, randomised, equivalence, double-masked clinical trial that aims to determine the clinical effectiveness and cost-effectiveness of subthreshold micropulse laser compared with standard threshold laser, for the treatment of diabetic macular oedema with CST < 400 μm. Read More

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http://dx.doi.org/10.1186/s13063-019-3199-5DOI Listing
February 2019
1 Read

Comparing habitual and i. Scription refractions.

BMC Ophthalmol 2019 Feb 12;19(1):49. Epub 2019 Feb 12.

Midwestern University, College of Optometry, 19555 N 59th Ave, Glendale, Arizona, 85308, USA.

Background: Many patients voice concerns regarding poor night vision, even when they see 20/20 or better in the exam room. During mesopic and scotopic conditions the pupil size increases, increasing the effects on visual performance of uncorrected (residual) refractive errors. The i. Read More

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http://dx.doi.org/10.1186/s12886-019-1053-xDOI Listing
February 2019

Impact of Corneoscleral Contact Lens Usage on Corneal Biomechanical Parameters in Keratoconic Eyes.

Eye Contact Lens 2019 Feb 4. Epub 2019 Feb 4.

Department of Optics, Optometry and Vision Sciences (E.P., J.C.M.), Physics College, University of Valencia, Burjassot, Valencia, Spain; Department of Surgery (E.E.-G.), Ophthalmology Unit, la Fe University and Polytechnic Hospital, Faculty of Medicine and Odontology, University of Valencia, Hospital la Fe, Valencia, Spain; and FISABIO Oftalmología Médica (C.P.-M.), Cornea Unit and Anterior Segment Diseases, Catholic University of Valencia, Valencia, Spain.

Objective: To analyze the changes in corneal biomechanical parameters of keratoconic eyes with and without intracorneal ring segment (ICRS) implants after 1 year of corneoscleral contact lens (CScL) wear.

Methods: Seventy-four eyes of 74 patients were divided into three groups: healthy subjects (29 eyes, control group), and 2 groups of subjects with keratoconic eyes (one group of 20 eyes with ICRS implants and one of 25 eyes without them), which were fitted with CScL. Corneal hysteresis (CH), corneal resistance factor (CRF), and corneal-compensated intraocular pressure (IOPcc) were evaluated before fitting CScL and after 1 year of CScL wear. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000579DOI Listing
February 2019
2 Reads

The effects of auditory satellite navigation instructions and visual blur on road hazard perception.

Accid Anal Prev 2019 Feb 8;125:132-137. Epub 2019 Feb 8.

School of Optometry and Vision Science and Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia.

The distracting effects of mobile telephone use while driving are well known, however the effects of other sources of distraction, such as auditory navigation devices, are less well understood. Whether the effects of auditory distraction might interact with other sensory impairments, such as vision impairment, is of interest given that visual impairment is relatively common within the population, particularly as a result of uncorrected refractive error. In this experiment, 20 current drivers (mean age of 29. Read More

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http://dx.doi.org/10.1016/j.aap.2019.01.025DOI Listing
February 2019

Portable Perimetry Using Eye-Tracking on a Tablet Computer-A Feasibility Assessment.

Transl Vis Sci Technol 2019 Jan 5;8(1):17. Epub 2019 Feb 5.

Division of Optometry and Visual Science, School of Health Sciences, City, University of London, London, UK.

Purpose: Visual field (VF) examination by standard automated perimetry (SAP) is an important method of clinical assessment. However, the complexity of the test, and its use of bulky, expensive equipment makes it impractical for case-finding. We propose and evaluate a new approach to paracentral VF assessment that combines an inexpensive eye-tracker with a portable tablet computer ("Eyecatcher"). Read More

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http://dx.doi.org/10.1167/tvst.8.1.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364754PMC
January 2019

Comparison of visual and optical quality of monofocal versus multifocal intraocular lenses.

Eur J Ophthalmol 2019 Feb 10:1120672119827858. Epub 2019 Feb 10.

1 Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.

Objective:: To compare visual quality in patients implanted with Tecnis monofocal (ZCB00) and multifocal (ZMB00) intraocular lenses taking into account their optical quality measured in vitro with an eye model.

Methods:: In total, 122 patients participated in this study: 44 implanted with monofocal and 78 with multifocal intraocular lenses. Measurements of visual acuity and contrast sensitivity were performed. Read More

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http://journals.sagepub.com/doi/10.1177/1120672119827858
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http://dx.doi.org/10.1177/1120672119827858DOI Listing
February 2019
1 Read

The construction and effect of physical properties on intracellular drug delivery of poly(amino acid) capsules.

Colloids Surf B Biointerfaces 2019 Jan 31;177:178-187. Epub 2019 Jan 31.

School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, Zhejiang Province, 325001, PR China; Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, CAS, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Constructing intracellular degradable drug delivery vehicles is critical to fully exert the function of loaded drugs. Considering the poly (amino acid) is sensitively degradable to acid and enzyme which indwell in the mature lysosome, we here presented the poly(amino acid) capsules constructed by the synthetic poly(amino acid), (poly-glutamic acid, PGA and poly-ornithine, POR). The fabrication of Dox loaded poly (amino acid) capsules was demonstrated, and was thoroughly characterized by various techniques, including Zetasizer, SEM, TEM, fluorescent microscopy, and confocal laser scan microscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.061DOI Listing
January 2019
1 Read

Abdominal obesity linked to a longer cone-mediated dark-adaptation recovery time in healthy eyes.

Exp Eye Res 2019 Feb 6;181:163-170. Epub 2019 Feb 6.

Applied Optics Complutense Group, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Av. Arcos de Jalón 118, Madrid, 28037, Spain.

Obesity has been associated with abnormal lipid metabolism and with tissue hypoxia. Human Bruch's membrane (BrM) lipid deposits have been proposed to create a diffusion barrier to metabolic exchange between the choroid and photoreceptors, delaying the regeneration of photopigments. The speed of retinal dark adaptation (DA) is dependent on the regeneration of these photopigments. Read More

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http://dx.doi.org/10.1016/j.exer.2019.02.007DOI Listing
February 2019

Permeability of the porcine iris stroma.

Exp Eye Res 2019 Feb 7;181:190-196. Epub 2019 Feb 7.

Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. Electronic address:

Current literature has not considered or provided any data on the permeability of the iris stroma. In this study, we aimed to determine the hydraulic permeability of porcine irides from the isolated stroma. Fifteen enucleated porcine eyes were acquired from the local abattoir. Read More

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http://dx.doi.org/10.1016/j.exer.2019.02.005DOI Listing
February 2019

Exploring the human factors of prescribing errors in paediatric intensive care units.

Arch Dis Child 2019 Feb 8. Epub 2019 Feb 8.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Objective: To explore the factors contributing to prescribing error in paediatric intensive care units (PICUs) using a human factors approach based on Reason's theory of error causation to support planning of interventions to mitigate slips and lapses, rules-based mistakes and knowledge-based mistakes.

Methods: A hierarchical task analysis (HTA) of prescribing was conducted using documentary analysis. Eleven semistructured interviews with prescribers were conducted using vignettes and were analysed using template analysis. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315981DOI Listing
February 2019

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on cataract.

Environ Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. Here, we present the protocol for two systematic reviews of parameters for estimating the number of disability-adjusted life years of cataracts from occupational exposure to solar ultraviolet radiation, to inform the development of the WHO/ILO joint methodology.

Objectives: We aim to systematically review studies on occupational exposure to solar ultraviolet radiation (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of occupational exposure to solar ultraviolet radiation on the development of cataract (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework and conducting both systematic reviews in tandem and in a harmonized way. Read More

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http://dx.doi.org/10.1016/j.envint.2018.10.001DOI Listing
February 2019
1 Read

Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

BMC Ophthalmol 2019 Feb 6;19(1):46. Epub 2019 Feb 6.

Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Background: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation.

Methods: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included. Read More

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http://dx.doi.org/10.1186/s12886-019-1060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368733PMC
February 2019

Community pharmacy integration within the primary care pathway for people with long-term conditions: a focus group study of patients', pharmacists' and GPs' experiences and expectations.

BMC Fam Pract 2019 Feb 8;20(1):26. Epub 2019 Feb 8.

Centre for Pharmacy Workforce Studies, Division of Pharmacy and Optometry, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

Background: This study aimed to use marketing theory to examine the views of patients, pharmacists and general practitioners (GPs) on how community pharmacies are currently used and to identify how community pharmacy services may be better integrated within the primary care pathway for people with long-term conditions (LTCs).

Methods: A qualitative research design was used. Two focus groups were conducted with respiratory patients (n = 6, 5) and two with type 2 diabetes patients (both n = 5). Read More

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http://dx.doi.org/10.1186/s12875-019-0912-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368723PMC
February 2019

Detection of Histamine Dihydrochloride at Low Concentrations Using Raman Spectroscopy Enhanced by Gold Nanostars Colloids.

Nanomaterials (Basel) 2019 Feb 6;9(2). Epub 2019 Feb 6.

Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología, Universidad Autónoma de San Luis Potosí, 78210 San Luis Potosí, Mexico.

In this paper, we report a fast and easy method to detect histamine dihydrochloride using gold nanostars in colloidal aqueous solution as a highly active SERS platform with potential applications in biomedicine and food science. This colloid was characterized with SEM and UV⁻Vis spectroscopy. Also, numerical calculations were performed to estimate the plasmonic resonance and electric field amplification of the gold nanoparticles to compare the difference between nanospheres and nanostars. Read More

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http://dx.doi.org/10.3390/nano9020211DOI Listing
February 2019

Binocular Eye Movements are Adapted to the Natural Environment.

J Neurosci 2019 Feb 7. Epub 2019 Feb 7.

Vision Science Program, School of Optometry University of California, Berkeley 360 Minor Hall, Berkeley CA, 94720, USA.

Humans and many animals make frequent saccades requiring coordinated movements of the eyes. When landing on the new fixation point, the eyes must converge accurately or double images will be perceived. We asked whether the visual system uses statistical regularities in the natural environment to aid eye alignment at the end of saccades. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2591-18.2018DOI Listing
February 2019

Removal of copper ions from water using polysaccharide-constructed hydrogels.

Carbohydr Polym 2019 Apr 8;209:101-110. Epub 2019 Jan 8.

School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, 32500, China. Electronic address:

Polysaccharides are an important class of materials that are often exploited in the fields of food, agriculture, biomedical engineering and wastewater treatment owing to their unique and tunable properties. In this work, we utilize an inexpensive and sustainable extracellular polysaccharide salecan (EPS), which is produced by bacterium Agrobacterium sp. ZX09, as a hydrogel matrix, poly(3-sulfopropyl methacrylate potassium salt) (PSM) as side chains to fabricate EPS-grafted-PSM adsorbents through a simple one-pot approach. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.01.015DOI Listing

Effect of contact lenses on ocular biometric measurements based on swept-source optical coherence tomography.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):129-135. Epub 2019 Jan 10.

Department of Optics and Optometry and Vision Sciences. University of Valencia, Spain.

Purpose: To determine the reliability of swept- source optical coherence tomography in cases in which soft contact lenses cannot be removed when acquiring biometric measurements.

Methods: Eight subjects were included and only one eye per participant was analyzed. Each eye was measured six times by swept-source optical coherence tomography with the IOLMaster 700 instrument (Carl Zeiss Meditec, Jena, Germany). Read More

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http://www.gnresearch.org/doi/10.5935/0004-2749.20190020
Publisher Site
http://dx.doi.org/10.5935/0004-2749.20190020DOI Listing
January 2019
2 Reads

Analysis of pattern electroretinogram signals of early primary open-angle glaucoma in discrete wavelet transform coefficients domain.

Int Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Optometry, School of Rehabilitation Science, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate discrete wavelet transform coefficients and identify descriptors of pattern electroretinogram (PERG) waveforms in order to determine PERG characteristics for optimizing the diagnosis of early primary open-angle glaucoma (POAG).

Methods: Pattern electroretinogram was performed in 30 normal eyes and 30 eyes with primary open-angle glaucoma according to the ISCEV protocol. The check size was 0. Read More

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http://dx.doi.org/10.1007/s10792-019-01077-wDOI Listing
February 2019

Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFκB, and AMPK pathways in H460 cells.

Environ Toxicol 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology and Immunology, School of Medicine, and Chung Shan Medical University; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, 402, Taiwan.

Prospective cohort studies have indicated that a highly nickel-polluted environment may severely affect human health, resulting in such conditions as respiratory tract cancers. Such exposure can trigger vascular endothelial growth factor (VEGF) expression. However, the signal transduction pathways leading to VEGF induction by nickel compounds are not well understood. Read More

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http://dx.doi.org/10.1002/tox.22731DOI Listing
February 2019
1 Read

Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours.

J Neuroinflammation 2019 Feb 5;16(1):25. Epub 2019 Feb 5.

Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Chimeric mouse models generated via adoptive bone marrow transfer are the foundation for immune cell tracking in neuroinflammation. Chimeras that exhibit low chimerism levels, blood-brain barrier disruption and pro-inflammatory effects prior to the progression of the pathological phenotype, make it difficult to distinguish the role of immune cells in neuroinflammatory conditions. Head-shielded irradiation overcomes many of the issues described and replaces the recipient bone marrow system with donor haematopoietic cells expressing a reporter gene or different pan-leukocyte antigen, whilst leaving the blood-brain barrier intact. Read More

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http://dx.doi.org/10.1186/s12974-019-1410-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362590PMC
February 2019

Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Evidera|PPD, Waltham, MA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Department of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Purpose: To assess overall prevalence, annual prevalence and incidence of dry eye disease (DED) in a large, representative population in the US.

Design: Prevalence and incidence study METHODS: Retrospective analysis using the Department of Defense (DOD) Military Health System (MHS) data on beneficiary medical claims from United States DOD military and civilian facilities, January 1, 2003-March 31, 2015.

Patient Population: Using an algorithm, medical diagnostic codes indicative of DED and prescriptions for cyclosporine ophthalmic emulsion identified a DED population from 9. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.026DOI Listing
February 2019
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A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):559-569

School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom.

Purpose: The rapid rise in prevalence over recent decades and high heritability of myopia suggest a role for gene-environment (G × E) interactions in myopia susceptibility. Few such G × E interactions have been discovered to date. We aimed to test the hypothesis that genetic analysis of susceptibility to visual experience-induced myopia in an animal model would identify novel G × E interaction loci. Read More

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http://dx.doi.org/10.1167/iovs.18-25597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363377PMC
February 2019
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An Evaluation of a Battery of Functional and Structural Tests as Predictors of Likely Risk of Progression of Age-Related Macular Degeneration.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):580-589

Division of Optometry and Visual Sciences, School of Health Sciences, City, University of London, London, United Kingdom.

Purpose: To evaluate the ability of visual function and structural tests to identify the likely risk of progression from early/intermediate to advanced AMD, using the Age-Related Eye Disease Study (AREDS) simplified scale as a surrogate for risk of progression. The secondary aim was to determine the relationship between disease severity grade and the observed functional and structural deficits.

Methods: A total of 100 participants whose AMD status varied from early to advanced were recruited. Read More

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http://dx.doi.org/10.1167/iovs.18-25092DOI Listing
February 2019

Stimulation of Retinal Pigment Epithelium With an α7 nAChR Agonist Leads to Müller Glia Dependent Neurogenesis in the Adult Mammalian Retina.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):570-579

Western Michigan University, Department of Biological Sciences, Kalamazoo, Michigan, United States.

Purpose: The adult mammalian retina is typically incapable of regeneration when damaged by disease or trauma. Restoration of function would require generation of new adult neurons, something that until recently, mammals were thought to be incapable of doing. However, previous studies from this laboratory have shown that the α7 nicotinic acetylcholine receptor (α7 nAChR) agonist, PNU-282987, induces cell cycle reentry of Müller glia and generation of mature retinal neurons in adult rats, in the absence of detectible injury. Read More

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http://dx.doi.org/10.1167/iovs.18-25722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363405PMC
February 2019

Impact of Children's Postural Variation on Viewing Distance and Estimated Visual Acuity.

Transl Vis Sci Technol 2019 Jan 30;8(1):16. Epub 2019 Jan 30.

School of Optometry and Vision Science, The University of Auckland, Auckland, New Zealand.

Purpose: Reliable estimation of visual acuity requires that observers maintain a constant distance from the target, but use of chin rests is not always feasible. Our aim was to quantify children's movement during community testing and its impact on near (40 cm) and intermediate (150 cm) acuity measures.

Methods: Thirty-three 7-year-old children performed several acuity tests run on a tablet computer, administered in the child's home by a trained lay screener. Read More

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http://dx.doi.org/10.1167/tvst.8.1.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357903PMC
January 2019

Impact of Defocus and High-Order Aberrations on Light Disturbance Measurements.

J Ophthalmol 2019 2;2019:2874036. Epub 2019 Jan 2.

Clinical Experimental Optometry Research Laboratory (CEORLab), Center of Physics, School of Sciences, University of Minho, Braga, Portugal.

Purpose: To evaluate the impact of different levels of positive and negative defocus on light disturbance (LD) measures and to understand how high-order aberrations (HOAs) and topographic quality parameters may influence the perception of photic phenomena.

Methods: Thirty young healthy subjects (21 females and 9 males) attended this cross-sectional study. LD was evaluated with the light distortion analyzer (LDA) in natural accommodative and cycloplegic conditions with positive and negative induced defocus of 1. Read More

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http://dx.doi.org/10.1155/2019/2874036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334342PMC
January 2019

The Topographical Effect of Optical Zone Diameter in Orthokeratology Contact Lenses in High Myopes.

J Ophthalmol 2019 2;2019:1082472. Epub 2019 Jan 2.

Department of Optics II (Optometry and Vision), Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain.

Purpose: To evaluate the effect of the optical zone diameter (OZ) in orthokeratology contact lenses regarding the topographical profile in patients with high myopia (-4.00 D to -7.00 D) and to study its effect over the visual quality. Read More

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http://dx.doi.org/10.1155/2019/1082472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334375PMC
January 2019

Induced vergence-accommodation conflict reduces cognitive performance in the Stroop test.

Sci Rep 2019 Feb 4;9(1):1247. Epub 2019 Feb 4.

IRIS Group, Physiopathologie de la Vision et Motricité Binoculaire CNRS FR3636, Université Paris Descartes, Paris, France.

Interaction mechanisms between cognition and binocular motor control in reading saccades remain unclear. In this study we examine objectively saccades and fixations parameters during the Stroop test, involving three different levels of cognitive demand (reading, color denomination and interference). In addition, we experimentally induce accommodation and vergence conflicts during the different tasks. Read More

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http://dx.doi.org/10.1038/s41598-018-37778-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361994PMC
February 2019

Effect of prism adaptation on neglect hemianesthesia.

Cortex 2019 Jan 14;113:298-311. Epub 2019 Jan 14.

Neuropsychological Service, Rehabilitation Department, A.S.S.T. Valle Olona, Varese, Italy.

Prism adaptation (PA) has proven to be effective in alleviating many signs of unilateral spatial neglect (USN). Generally, the principal improvement after PA treatment was found to be in the high-level cognitive function. Nevertheless, some evidence has also been found for it in somatosensory function. Read More

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http://dx.doi.org/10.1016/j.cortex.2018.12.021DOI Listing
January 2019
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Objective Morphological Classification of Neocortical Pyramidal Cells.

Cereb Cortex 2019 Jan 31. Epub 2019 Jan 31.

Blue Brain Project, Brain and Mind Institute, EPFL, Campus Biotech: CH 1202, Geneva, Switzerland.

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies. Even for neurons that are visually distinguishable, there is no common ground to consistently define morphological types. The objective classification of PCs can be achieved with methods from algebraic topology, and the dendritic arborization is sufficient for the reliable identification of distinct types of cortical PCs. Read More

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http://dx.doi.org/10.1093/cercor/bhy339DOI Listing
January 2019
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Reliability and validity of the Canadian-French ecological adaptation of the weighted version of the Melbourne low-vision ADL Index.

Disabil Rehabil 2019 Feb 3:1-10. Epub 2019 Feb 3.

a Institut Nazareth et Louis-Braille du CISSS de la Montérégie-Centre , Longueuil , Canada.

Background: The Mesure de l'impact de la déficience visuelle dans les activités quotidiennes (MIDVAQ) is the Canadian-French adaptation of the Melbourne Low-Vision ADL Index. It measures performance, personal importance and handicap situation in 16 instrumental activities requiring near vision (standardized material, part A) and in 9 self-care and domestic activities (self-report questionnaire, part B). This study aimed at measuring the MIDVAQ reliability and its relationship with measures of visual functions and functional vision. Read More

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http://dx.doi.org/10.1080/09638288.2018.1516813DOI Listing
February 2019

Bulk changes in posterior scleral collagen microstructure in human high myopia.

Mol Vis 2018 30;24:818-833. Epub 2018 Dec 30.

Structural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK.

Purpose: We aimed to characterize any bulk changes in posterior scleral collagen fibril bundle architecture in human eyes with high myopia.

Methods: Wide-angle X-ray scattering (WAXS) was employed to map collagen orientation at 0.5 mm × 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334987PMC
December 2018