20,631 results match your criteria Optometry Times [Journal]


Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I-IV drugs.

J Pharmacokinet Pharmacodyn 2018 Dec 14. Epub 2018 Dec 14.

Centre for Applied Pharmacokinetic Research, Division of Pharmacy & Optometry, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

Regulatory agencies have a strong interest in sensitivity analysis for the evaluation of physiologically-based pharmacokinetic (PBPK) models used in pharmaceutical research and drug development and regulatory submissions. One of the applications of PBPK is the prediction of fraction absorbed and bioavailability for drugs following oral administration. In this context, we performed a variance based global sensitivity analysis (GSA) on in-house PBPK models for drug absorption, with the aim of identifying key parameters that influence the predictions of the fraction absorbed and the bioavailability for neutral, acidic and basic compounds. Read More

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December 2018

Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5.

Biomed Pharmacother 2019 Jan 26;109:1826-1833. Epub 2018 Nov 26.

Department of Optometry, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.

Objective: Astragaloside (AST) is a kind of effective components of Astragalus membranaceus, which has been reported to exert extensive pharmacological actions in various diseases. However, the effect of AST on optic nerve injury remains unclear. The study aimed to uncover the effect of AST on oxygen glucose deprivation (OGD)-induced RGC-5 cells injury and the underlying mechanism. Read More

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January 2019

Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5932-5940

Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

Purpose: To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT).

Methods: Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Read More

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December 2018
1 Read

Stronger Responses to Darks Along the Ventral Pathway of the Cat Visual Cortex.

Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

School of Optometry, Université de Montréal, CP 6128 succursale centre-ville, Montreal, Quebec, Canada.

Light increments (brights) and decrements (darks) are differently processed throughout the early visual system. It is well known that a bias towards faster and stronger responses to darks is present in the retina, lateral geniculate nucleus and primary visual cortex. In humans, psychophysical and neurophysiological data indicate that darks are better detected than brights, suggesting that the dark bias found in early visual areas is transmitted across the cortical hierarchy. Read More

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December 2018

Repeatability and reliability of quantitative fundus autofluorescence imaging in patients with early and intermediate age-related macular degeneration.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Optometry, Vienna Trial Center (VTC), Medical University of Vienna, Vienna, Austria.

Purpose: Quantification of fundus autofluorescence has only recently become available. We report our findings on the evaluation of the repeatability and reliability of quantitative fundus autofluorescence (qAF) measurements in patients with early and intermediate age-related macular degeneration (AMD), using the first approved and commercially available instrument.

Methods: A total of 43 eyes of 22 patients (aged between 52 and 84 years) diagnosed with early and intermediate AMD were included. Read More

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December 2018

Review of rodent hypertensive glaucoma models.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong.

Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. Read More

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December 2018

Lactoferrin-loaded contact lenses counteract cytotoxicity caused in vitro by keratoconic tears.

Cont Lens Anterior Eye 2018 Dec 11. Epub 2018 Dec 11.

Department of Biotechnology and Biosciences, University of Milano - Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy; Optic and Optometry Center of the University of Milano - Bicocca (COMiB), Italy.

Lactoferrin (LF), an iron-binding protein with antioxidant activity, is significantly reduced in the lacrimal film of patients affected by keratoconus (KC) compared to healthy subjects, and this is supposed to be the cause for tear iron increase and consequent iron deposition and oxygen free radical accumulation in the cornea. We decided to study if LF-loaded contact lenses (LF-CLs) could exert antioxidant activity on epithelial cells incubated in tears collected from two patients affected by keratoconus (KC1 and KC2). Moreover through this model we indirectly estimated iron concentration in the tears of healthy and KC subjects. Read More

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December 2018

Tear dynamics under scleral lenses.

Cont Lens Anterior Eye 2018 Dec 10. Epub 2018 Dec 10.

Clinical Research Center, School of Optometry, University of California, Berkeley, United States; Vision Science Graduate Program, University of California, Berkeley, United States. Electronic address:

Purpose: To evaluate post-lens tear dynamics at two different time points during scleral lens wear in two cohorts with 10 neophytes each.

Methods: All subjects wore bilaterally scleral lenses for 5 h on 3 separate visits. Post-lens tear exchange was measured using Out-in method, which required 5 μL of 2% FITC-Dextran instilled on the bulbar conjunctiva during lens wear. Read More

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December 2018

Student acceptance of e-learning methods in the laboratory class in Optometry.

PLoS One 2018 13;13(12):e0209004. Epub 2018 Dec 13.

School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.

Today's students have increased expectations for flexible learning options and evidence-based practice resources to be available to support curricular activities. We investigated: (i) the suitability of a static website for teaching ocular anatomy and physiology and an interactive version of the website with quiz and self-assessment activities and (ii) the usefulness of a blended online and in-lab environment to teach in Optometry. We administered a survey to compare responses of optometry students who had access to the interactive website, with those from students from a previous year who used the static version. Read More

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December 2018

Reducing the impact of the impending myopia epidemic in New Zealand.

N Z Med J 2018 Dec 14;131(1487):80-85. Epub 2018 Dec 14.

Ophthalmologist, Gisborne; Senior Lecturer, Dept of Ophthalmology, University of Otago.

Myopia is an eye condition that is increasing around the world, reaching epidemic levels in many countries. It is associated with a higher risk of other ocular diseases including myopic maculopathy and retinal detachment. Historically in New Zealand myopia has existed at a low level, however the environmental changes that have increased myopia internationally will affect New Zealanders too. Read More

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December 2018

Factors Affecting the Levels of Satisfaction With Nurse-Patient Communication Among Oncology Patients.

Cancer Nurs 2018 Dec 12. Epub 2018 Dec 12.

Author Affiliations: Schools of Nursing (Drs Lam and Chan) and Optometry (Dr Wong), The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.

Background: Nurse-patient communication is of the utmost importance to oncology patients.

Objective: The aim of this study was to investigate the factors influencing the level of satisfaction with nurse-patient communication among oncology patients during their daily routine procedures.

Methods: In this observational study, 25 registered nurses and 94 patients were recruited from an oncology unit. Read More

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December 2018
1.931 Impact Factor

Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

The Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts.

Importance: To facilitate drug and device development for neonates, the International Neonatal Consortium brings together key stakeholders, including pharmaceutical companies, practitioners, regulators, funding agencies, scientists, and families, to address the need for objective, standardized clinical trial outcome measurements to fulfill regulatory requirements. Retinopathy of prematurity (ROP) is a disease that affects preterm neonates. The current International Classification of Retinopathy of Prematurity does not take into account all of the characteristics of ROP and does not adequately discriminate small changes in disease after treatment. Read More

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December 2018

Gene-based therapeutic tools in the treatment of Cornea Disease.

Curr Gene Ther 2018 Dec 13. Epub 2018 Dec 13.

Tianjin Medical University Eye Hospital, The College of Optometry, Tianjin 300384. China.

Background: As one of the main blinding ocular diseases, corneal blindness results from neovascularization that disrupts the angiogenic privilege of corneal avascularity. Following neovascularization, inflammatory cells are infiltrating into corneal to strengthen corneal injury. How to maintain corneal angiogenic privilege to treat corneal disease has been investigated for decades. Read More

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December 2018

Self-face and self-body advantages in congenital prosopagnosia: evidence for a common mechanism.

Exp Brain Res 2018 Dec 12. Epub 2018 Dec 12.

NeuroMI-Milan Center for Neuroscience, Milano, Italy.

Prosopagnosia is a disorder leading to difficulties in recognizing faces. However, recent evidence suggests that individuals with congenital prosopagnosia can achieve considerable accuracy when they have to recognize their own faces (self-face advantage). Yet, whether this advantage is face-specific or not is still unclear. Read More

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December 2018

Immunotoxin-Induced Ablation of the Intrinsically Photosensitive Retinal Ganglion Cells in Rhesus Monkeys.

Front Neurol 2018 27;9:1000. Epub 2018 Nov 27.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, United States.

Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment. The goal of this study was to develop and validate a targeted ipRGC immunotoxin to ultimately examine the role of ipRGCs in macaque monkeys. An immunotoxin for the macaque melanopsin gene (), consisting of a saporin-conjugated antibody directed at the N-terminus, was prepared in solutions of 0. Read More

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November 2018

Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment in Eyes with Proliferative Diabetic Retinopathy.

J Ophthalmol 2018 6;2018:3470731. Epub 2018 Nov 6.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: To evaluate logical surgical approaches to closing macular holes in eyes with proliferative diabetic retinopathy with retinal detachment.

Methods: Retrospective, interventional case series.

Results: 10 eyes in 10 patients were included in this study. Read More

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November 2018

Protective Effects of Extracts on UVB-Induced Damage in Human Retinal Pigment Epithelial Cells Accompanied by Attenuating ROS and DNA Damage.

Oxid Med Cell Longev 2018 7;2018:4814928. Epub 2018 Nov 7.

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The medicinal herb fruit has been widely used for improving and maintaining the health of the eyes in the Far East for many centuries. This study is aimed at investigating whether protective effects generated from the aqueous (LBA) and ethanol (LBE) extracts of the fruit existed against oxidative stress-induced apoptosis in human retinal pigment epithelial cells. extracts LBA and LBE exerted the activity of ROS scavenging and rescued UVB irradiation-induced growth inhibition in retinal pigment epithelial ARPE-19 cells. Read More

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November 2018

Vision Loss from Choroidal and Pituitary Metastases Secondary to Renal Cell Carcinoma: A Case Report.

Neuroophthalmology 2018 Dec 19;42(6):391-398. Epub 2018 Jun 19.

Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.

A 62-year-old male with a history of metastatic clear cell renal cell carcinoma (ccRCC) presented with decreased vision to 20/50 in the left eye. Fundus examination revealed an elevated, amelanotic mass lesion in the superotemporal macula, without involvement of the central macula by subretinal fluid or tumour. Given incongruity between the fundus findings and the degree of visual impairment, visual field testing was obtained, revealing a bitemporal hemianopia. Read More

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December 2018

Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-TAM) in Human Corneal Keratocytes.

Front Endocrinol (Lausanne) 2018 22;9:670. Epub 2018 Nov 22.

Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

This study was undertaken to determine if crosstalk among the transient receptor potential (TRP) melastatin 8 (TRPM8), TRP vanilloid 1 (TRPV1), and vascular endothelial growth factor (VEGF) receptor triad modulates VEGF-induced Ca signaling in human corneal keratocytes. Using RT-PCR, qPCR and immunohistochemistry, we determined TRPV1 and TRPM8 gene and protein coexpression in a human corneal keratocyte cell line (HCK) and human corneal cross sections. Fluorescence Ca imaging using both a photomultiplier and a single cell digital imaging system as well as planar patch-clamping measured relative intracellular Ca levels and underlying whole-cell currents. Read More

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November 2018

Global Activity Shaping Strategies for a Retinal Implant.

J Neural Eng 2018 Nov 13. Epub 2018 Nov 13.

Department of Biomedical Engineering, University of Melbourne, Parkville, Victoria, AUSTRALIA.

Objective: Retinal prostheses provide visual perception via electrical stimulation of the retina using an implanted array of electrodes. The retinal activation resulting from each electrode is not point-like; instead each electrode introduces a spread of retinal activation that may overlap with activations from other electrodes. With most conventional stimulation strategies this overlap leads to image blur. Read More

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November 2018

Patient Reported Outcomes, Functional Assessment and Utility Values in Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Johns Hopkins Wilmer Eye Institute, Maryland USA.

In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Read More

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December 2018
2 Reads

PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population.

DNA Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University , Wenzhou, Zhejiang, China .

Acute anterior uveitis (AAU) is an ordinary type of uveitis, which is an autoimmune disease produced by T cells. Programmed apoptosis protein 1 (PD-1) is a vital negative regulatory protein of immune tolerance. We detect the single nucleotide polymorphisms (SNPs) rs41386349, rs10204525, and rs2227982 of PD-1 to investigate the correlation between PD-1 polymorphisms and AAU. Read More

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December 2018

A novel scale for describing corneal staining.

Clin Ophthalmol 2018 19;12:2369-2375. Epub 2018 Nov 19.

Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada,

The assessment of corneal staining is a commonly conducted procedure in both clinical practice and as part of various research studies. Different grading scales are employed by many clinicians and researchers to undertake this procedure for corneal staining comparisons between eyes, products and over time. This paper describes the development and use of a grading scale for corneal staining undertaken at an academic research site. Read More

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November 2018

Clinical factors associated with contact lens dropout.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Centre for Ocular Research and Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.

Purpose: Contact lens (CL) dropout is estimated to be approximately equal to the number of new wearers per year, resulting in virtually no growth in the global CL market. The purpose of this study was to determine ocular and CL factors associated with CL dropout.

Methods: This five-site study recruited subjects 18-45 years of age who had ceased CL wear within the past 6-12 months due to discomfort. Read More

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December 2018

Enantioselective LC-MS/MS for anthropogenic markers of septic tank discharge.

Chemosphere 2018 Dec 3;219:191-201. Epub 2018 Dec 3.

School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, AB10 7GJ, UK. Electronic address:

Households in rural locations utilize septic tanks for wastewater treatment and can cause surface water contamination. A new methodology was developed to help investigate the role septic tanks play in the dissemination of prescription and over-the-counter drugs, personal care products and stimulants in the aqueous environment. Simultaneous analysis of 16 chiral and achiral anthropogenic markers was achieved using a Chirobiotic V2 enantioselective column in polar ionic mode. Read More

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December 2018
1 Read

Thermo-sensitive nanogel-laden bicontinuous microemulsion drug-eluting contact lenses.

J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomedical Engineering, School of Medicine, Catholic University of Daegu, Daegu, 42472, South Korea.

The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Read More

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December 2018
1 Read

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease.

J Mol Med (Berl) 2018 Dec 8. Epub 2018 Dec 8.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More

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December 2018

A New Method to Analyze the Relative Corneal Refractive Power and Its Association to Myopic Progression Control With Orthokeratology.

Transl Vis Sci Technol 2018 Nov 30;7(6):17. Epub 2018 Nov 30.

School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin, China.

Purpose: We present a new method for analyzing relative corneal refractive power (RCRP) in children undergoing orthokeratology and explore its potential association to effective myopic control.

Methods: A total of 55 children aged 8 to 12 years participated in the study. Axial growth was calculated as the difference in axial length before and 1 year after orthokeratology. Read More

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November 2018

Effect of the Decrease in Luminance Noise Range on Color Discrimination of Dichromats and Trichromats.

Front Behav Neurosci 2018 23;12:292. Epub 2018 Nov 23.

Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.

Color vision assessment can be done using pseudoisochromatic stimuli, which has a luminance noise to eliminate brightness differences between the target and background of the stimulus. It is not clear the influence of the luminance noise on color discrimination. We investigated the effect of change in the luminance noise limits on color discrimination. Read More

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November 2018
1 Read

Loss of Function in exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride.

Appl Environ Microbiol 2018 Dec 7. Epub 2018 Dec 7.

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Stopford Building, The University of Manchester, Manchester, UK

Assessing the risk of resistance associated with biocide exposure commonly involves exposing microorganisms to biocides at concentrations close to the MIC. With the aim of representing exposure to environmental biocide residues, MG1655 was grown for 20 passages in the presence or absence of benzalkonium chloride (BAC) at 100 ng/L and 1000 ng/L (0.0002% and 0. Read More

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December 2018

Insight into the mechanism and factors on encapsulating basic model protein, lysozyme, into heparin doped CaCO.

Colloids Surf B Biointerfaces 2018 Nov 29;175:184-194. Epub 2018 Nov 29.

School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, Zhejiang Province, 325001, PR China; Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, CAS, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Porous CaCO microparticles are considered as one of the most popular and effective carriers for protein loading. Most of current studies have centered on elucidating particle formation and enhancing the protein loading efficiency, very few reports on the kinetics, driving forces and factors on protein loading process. Here, we took lysozyme as the basic model protein to investigate the kinetics, driving forces on protein loading and factors controlling loading efficiency into porous Hep/CaCO microparticles by various techniques (protein quantification assay, QCM-D, SEM, BET, Zeta sizer, TGA, CLSM, CD spectrum, bioactive assay). Read More

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November 2018

Hydrophobic drug adsorption loss to syringe filters from a perspective of drug delivery.

J Pharmacol Toxicol Methods 2018 Dec 5;95:79-85. Epub 2018 Dec 5.

Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, China; Jacob's Retina Center at Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA 92037-0946, United States. Electronic address:

Filtering with a syringe filter is a common operation in pharmaceutical analysis. Ophthalmic research often has a limited amount of sample and low amount of drug which is vulnerable to filtering membrane adsorption loss but not well recognized in the research community. Current study investigated drug adsorption by 11 types of syringe filters for 4 hydrophobic compounds commonly encountered in transscleral drug delivery. Read More

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December 2018

[Outcomes of 27G(+) transconjunctival sutureless vitrectomy for posterior segment disease].

Authors:
J P Liu Y Shao X R Li

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922

Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.

To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More

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December 2018

Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection.

Ophthalmic Res 2018 Dec 6:1-5. Epub 2018 Dec 6.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu,

Purpose: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR).

Methods: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. Read More

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December 2018
1 Read
1.376 Impact Factor

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018
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Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.

On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More

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December 2018
6 Reads

Eye and Vision Health for Tomorrow: From Recommendations to Coordinated Action.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Indiana University School of Optometry, Bloomington.

In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue initiated by this report. In 2018, a stakeholder meeting assessed the feasibility of establishing a backbone organization, a national center that can provide technical and resource assistance regarding eye and vision health. Read More

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December 2018
3 Reads

Re: Does the temperature of an artificial tear affect its comfort?

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia.

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December 2018

Impact of image averaging on wide-field choroidal thickness measurements using enhanced-depth imaging optical coherence tomography.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.

Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More

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December 2018
1 Read

Comparing spectacle and toric contact lens prescribing trends for astigmatism.

Clin Optom (Auckl) 2018 8;10:119-127. Epub 2018 Nov 8.

DAVICH Optical Chain, Daechi-dong, Gangnam-gu, Seoul, South Korea.

Background: The purpose of this study is to investigate and compare spectacle and contact lens (CL) prescription trends, with an emphasis on astigmatic refractive error prescribing differences for patients who purchase spectacles or CLs in South Korea.

Methods: A retrospective study of patient records of a major optical chain in South Korea was conducted. De-identified data of age, gender, power of prescribed spectacles and/or CLs were extracted from the practice database. Read More

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November 2018
1 Read

Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt-β-catenin pathway.

Onco Targets Ther 2018 9;11:7987-7999. Epub 2018 Nov 9.

School of Laboratory Medicine and Life Science, Wenzhou Medical University, Zhejiang, People's Republic of China,

Background: Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal cancer cell lines and its molecular mechanism.

Methods: Lupeol was assessed for its anticancer effect using two human colorectal cancer cell lines: SW480 and HCT116. Read More

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November 2018
2 Reads

A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Vitreous Retina Macula Consultants of New York, New York, NY, USA.

Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).

Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More

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December 2018
1 Read

2018 American Academy of Optometry Ocular Photography Contest.

Authors:

Optom Vis Sci 2018 Dec;95(12):1162-1165

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December 2018
1 Read

Optometry and Vision Science: 2018 Year End Review.

Authors:
Michael Twa

Optom Vis Sci 2018 Dec;95(12):1087

Editor in Chief Birmingham, AL.

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December 2018

Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation.

J Mater Sci Mater Med 2018 Nov 30;29(12):182. Epub 2018 Nov 30.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia.

3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. Read More

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November 2018
4 Reads

Data on differentially expressed proteins in retinal emmetropization process in guinea pig using integrated SWATH-based and targeted-based proteomics.

Data Brief 2018 Dec 31;21:1750-1755. Epub 2018 Aug 31.

Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong.

Myopia is generally regarded as a failure of normal emmetropization process, however, its underlying molecular mechanisms are unclear. Retinal protein profile changes using integrated SWATH and MRM-HR MS were studied in guinea pigs at 3- and 21-days of age, where the axial elongation was significantly detected. Differential proteins expressions were identified, and related to pathways which are important in postnatal development in retina, proliferation, breakdown of glycogen-energy and visual phototransduction. Read More

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December 2018
1 Read

Optical Rehabilitation of a Patient with Keratoconus and Nystagmus.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):183-189

Kentucky College of Optometry, University of Pikeville, Pikeville, KY, USA.

Keratoconus is a progressive corneal disease characterized by bilateral yet usually asymmetric thinning of the cornea with an onset typically in teenage years. While it often presents as an isolated condition, keratoconus may also be associated with many systemic and/or ocular diseases, such as connective tissue and chromosomal disorders. Its association with nystagmus has been described in Leber's congenital amaurosis, where patients also exhibit abnormal pupillary responses, early-onset retinal dystrophy, mental developmental delays, and eventual blindness. Read More

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January 2018
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The Effect of Intravitreal Bevacizumab on Central Serous Chorioretinopathy.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):176-182

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

The aim of this study was to investigate the efficacy of Intravitreal Injection of Bevacizumab (IVB) in patients with Central Serous Chorioretinopathy (CSC) compared to the control group, after four months of injection. In this study, 30 eyes of 30 patients with CSC, who were in the age range of 23 to 50 years old (70% male subject) were included. Eligible patients were randomly allocated to the intervention (n = 15) and control groups (n = 15). Read More

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January 2018

A case of choroidal osteoma in a 17-year-old female.

Oman J Ophthalmol 2018 Sep-Dec;11(3):267-269

Department of Optometry, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.

A 17-year female was referred for complaints of blurring and decreased vision in the right eye. The patient underwent fundus examination, optical coherence tomography and B-scan ultrasonography. A well-defined, yellow-orange colored lesion was present in the posterior pole. Read More

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December 2018
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Myopia, the challenge of ophthalmology and its worldwide «explosive epidemic».

Arch Soc Esp Oftalmol 2018 Nov 27. Epub 2018 Nov 27.

Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, San Vicente del Raspeig, Alicante, España.

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November 2018