21,172 results match your criteria Optometry Times [Journal]


CD30 Aptamer-functionalized PEG-PLGA nanoparticles for the superior delivery of doxorubicin to anaplastic large cell lymphoma cells.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

School of Biological Science and Engineering, South China University of Technology, Guangzhou 510640, China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, Chinese Academy of Sciences, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Nanoparticles (NPs) conjugated with aptamers have been extensively in recent years, which can efficiently target cancer cells that improve the therapeutic effect. Aptamers (Apt) are small oligonucleotide molecule ligands have specific high-affinity. In this work, we developed a PEG-PLGA nanoparticles (NPs) encapsulated with doxorubicin. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.013DOI Listing

The Binocular Balance at High Spatial Frequencies as Revealed by the Binocular Orientation Combination Task.

Front Hum Neurosci 2019 2;13:106. Epub 2019 Apr 2.

McGill Vision Research, Department of Ophthalmology, McGill University, Montreal, QC, Canada.

How to precisely quantify the binocular eye balance (i.e., the contribution that each eye makes to the binocular percept) across a range of spatial frequencies using a binocular combination task, is an important issue in both clinical and basic research. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454030PMC

Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration.

Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

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http://dx.doi.org/10.3389/fnins.2019.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456690PMC

Functional characterization of CEP250 variant identified in nonsyndromic retinitis pigmentosa.

Hum Mutat 2019 Apr 18. Epub 2019 Apr 18.

Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Retinitis pigmentosa (RP) is the most common manifestation of inherited retinal diseases with high degree of genetic, allelic, and phenotypic heterogeneity. CEP250 encodes the C-Nap1 protein and has been associated with various retinal phenotypes. Here, we report the identification of a mutation (c. Read More

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http://dx.doi.org/10.1002/humu.23759DOI Listing

Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018.

PLoS One 2019 18;14(4):e0215528. Epub 2019 Apr 18.

Department of Optometry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Vernal keratoconjunctivitis is a chronic bilateral severe form of allergic conjunctivitis which affects normal activities in school/work. It is a severe form of allergies in warm and dry tropical and sub-tropical countries. Its prevalence in Ethiopia ranges from 5. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215528PLOS
April 2019
2 Reads

Top-down Mass Spectrometry of Intact Phosphorylated β-casein: Correlation between The Precursor Charge State and Internal Fragments.

J Mass Spectrom 2019 Apr 17. Epub 2019 Apr 17.

Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, OH, 43210, USA.

Phosphorylated proteins play essential roles in many cellular processes, and identification and characterization of the relevant phosphoproteins can help to understand underlying mechanisms. Herein, we report a collision-induced dissociation top-down approach for characterizing phosphoproteins on a quadrupole time-of-flight mass spectrometer. β-casein, a protein with two major isoforms and five phosphorylatable serine residues, was used as a model. Read More

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http://dx.doi.org/10.1002/jms.4364DOI Listing

Effects of scleral-lens oxygen transmissibility on corneal thickness: A pilot study.

Cont Lens Anterior Eye 2019 Apr 15. Epub 2019 Apr 15.

Clinical Research Center, School of Optometry, University of California, Berkeley, United States; Vision Science Graduate Program, University of California, Berkeley, United States. Electronic address:

Purpose: To investigate the effect of various oxygen transmissibilities (Dk/t) of scleral lenses and corneal thickness recovery time from overnight eye closure with patching on corneal edema during 5 h lens wear.

Methods: Scleral lenses (hofocon A, 15.6 mm diameter) were worn bilaterally with three different Dks (100, 140, and 160 Barrer). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13670484183080
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http://dx.doi.org/10.1016/j.clae.2019.04.002DOI Listing
April 2019
1 Read

Effect of modulating braille dot height on reading regressions.

PLoS One 2019 17;14(4):e0214799. Epub 2019 Apr 17.

The Smith-Kettlewell Eye Research Institute, San Francisco, California, United States of America.

It is well known that people who read print or braille sometimes make eye or finger movements against the reading direction. The way these regressions are elicited has been studied in detail by manipulating linguistic aspects of the reading material. Actually, it has been shown that reducing the physical intensity or clarity of the visual input signal can also lead to increased regressions during reading. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214799PLOS

Impact of Visual Cues on the Magnitude and Variability of the Accommodative Response in Children With Emmetropia and Uncorrected Hyperopia and Adults.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1527-1537

University of Houston, College of Optometry, Houston, Texas, United States.

Purpose: We investigated the effect of blur and disparity cues on accommodative accuracy (lag) and variability (time [RMS] and frequency domain [LFC]) in the developing visual system.

Methods: A total of 59 children (3-9 years, spherical equivalent refractive error [RE] = -0.3- +4. Read More

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http://dx.doi.org/10.1167/iovs.18-25256DOI Listing

Long-Term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis with Active Choroidal Neovascularization Managed with Intravitreal Bevacizumab.

Ocul Immunol Inflamm 2019 Apr 17:1-6. Epub 2019 Apr 17.

e School of Medicine , National Taiwan University , Taipei , Taiwan.

Purpose: To evaluate the long-term outcome of active choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) after intravitreal bevacizumab treatment.

Methods: Retrospective study of consecutive patients of PIC/MFC complicated with active CNV. Outcome measures included best-corrected visual acuity (BCVA), total number of intravitreal injections of bevacizumab and recurrence of CNV. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2019.1
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http://dx.doi.org/10.1080/09273948.2019.1588335DOI Listing
April 2019
1 Read

Validity of the +1.50 plus lens screening test as a predictor of uncorrected moderate hyperopia.

Ophthalmic Physiol Opt 2019 May;39(3):141-147

School of Optometry and Vision Science, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

Purpose: Screening for uncorrected hyperopia in school children is important given its association with poorer visual function and academic performance. However, standard distance visual acuity screening may not detect low to moderate hyperopia. The plus lens test is used to screen for hyperopia in many school screening protocols, but has not been well validated. Read More

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http://dx.doi.org/10.1111/opo.12617DOI Listing

Impact of optical coherence tomography on diagnostic decision-making by UK community optometrists: a clinical vignette study.

Ophthalmic Physiol Opt 2019 May;39(3):205-215

Division of Optometry and Visual Science, City University of London, London, UK.

Purpose: In recent years, there has been widespread investment in imaging technologies by community optometrists in the UK, most notably optical coherence tomography (OCT). The aim of the current study was to determine the value of OCT in the diagnosis of posterior segment diseases in a representative sample of community optometrists using a clinical vignette methodology.

Methods: A group of community optometrists (n = 50) initially completed a standardised training package on OCT interpretation followed by a computer-based assessment featuring 52 clinical vignettes, containing images of healthy (n = 8) or glaucomatous (n = 18) discs or healthy (n = 8) or diseased (n = 18) fundi. Read More

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http://dx.doi.org/10.1111/opo.12613DOI Listing

Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 9.

National Vision Research Institute, Australian College of Optometry, Carlton, Victoria 3053, Australia.

A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on the basis of their response linearity (Skottun et al., 1991). Read More

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http://dx.doi.org/10.1523/ENEURO.0480-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464514PMC

Microcirculation in the conjunctiva and retina in healthy subjects.

Eye Vis (Lond) 2019 6;6:11. Epub 2019 Apr 6.

2Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, McKnight Building - Room 202A, Miami, FL 33136 USA.

Background: The aim was to determine the relationship between bulbar conjunctival microcirculation and retinal microcirculation in a healthy population.

Method: A functional slit-lamp biomicroscope (FSLB) was used to measure blood flow velocity (BFV) and blood flow rate (BFR) in the conjunctiva while a retinal function imager (RFI) was used to measure macular BFV and BFR in the retina. One eye of each subject of 58 self-reported healthy subjects was imaged in the same session on the same day. Read More

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https://eandv.biomedcentral.com/articles/10.1186/s40662-019-
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http://dx.doi.org/10.1186/s40662-019-0136-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451216PMC
April 2019
1 Read

A novel minimal fluid technique for effective and safe lens hydrodissection during cataract surgery.

Taiwan J Ophthalmol 2019 Jan-Mar;9(1):43-45

Universal Eye Center, Taipei, Taiwan.

Traditional hydrodissection may cause posterior capsule rupture (PCR) if excessive fluid accumulates. In this study, we describe the successful application of a novel minimal fluid hydrodissection technique in 100 consecutive cataract surgery cases. This technique separates the nucleus from the capsule utilizing low hydrostatic pressure and precise kinetic movement of a small volume (around 0. Read More

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http://dx.doi.org/10.4103/tjo.tjo_137_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432847PMC

Accuracy of new and standard intraocular lens power calculations formulae in Saudi pediatric patients.

Taiwan J Ophthalmol 2019 Jan-Mar;9(1):37-42

Optometry and Investigations Department, Dhahran Eyes Specialist Hospital, Dhahran, Saudi Arabia.

Purpose: The purpose of this study is to compare the accuracy of new generation formulas to standard formulas for intraocular lens (IOL) power calculations in pediatric patients.

Subjects And Methods: This retrospective case series compared the postoperative refractions to the predicted refractions after lensectomy and IOL implantation in pediatric patients. Four new generation formulas (Haigis, Holladay II, Olsen, and Barrett Universal II) were compared to four standard formulas (Holladay I, Hoffer Q, SRK/T, and SRKII) 4. Read More

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http://dx.doi.org/10.4103/tjo.tjo_71_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432852PMC

Optical Coherence Tomography Angiography Compared with Indocyanine Green Angiography in Central Serous Chorioretinopathy.

Sci Rep 2019 Apr 16;9(1):6149. Epub 2019 Apr 16.

Ophthalmology Optometry Centre, Peking University People's Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, 100044, China.

The purpose of this article is to compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC). OCTA, ICGA and fluorescein angiography (FA) images of all enrolled patients were collected and compared. Abnormal areas were annotated on en face choriocapillaris OCTA and ICGA images and compared with each other. Read More

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http://dx.doi.org/10.1038/s41598-019-42623-xDOI Listing

Using the ICF to examine contextual factors that influence participation of people with deafblindness in India.

Arch Phys Med Rehabil 2019 Apr 12. Epub 2019 Apr 12.

School of Rehabilitation Therapy, Queen's University, Kingston, Ontario, Canada.

Objective: To identify and describe the contextual factors that influence the participation of people with deafblindness in India.

Design: Qualitative study, using directed content analysis approach and the International Classification of Functioning, Disability and Health as a framework to analyze the data.

Setting: Community and social participation settings PARTICIPANTS: Sixteen community-dwelling individuals with deafblindness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039993193024
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http://dx.doi.org/10.1016/j.apmr.2019.03.010DOI Listing
April 2019
1 Read

Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes: A Population-Based Cohort Study Assessing Sex Disparities.

Circulation 2019 Apr 15. Epub 2019 Apr 15.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK; Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.

Background: With recent changes in UK clinical practice for diabetes care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.

Methods: In this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79,985 patients with incident T2DM between 2006-2013 matched to 386,547 patients without diabetes. Sex-stratified Cox models were used to assess cardiovascular risk. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039100DOI Listing

Accessory genome of the multi-drug resistant ocular isolate of Pseudomonas aeruginosa PA34.

PLoS One 2019 15;14(4):e0215038. Epub 2019 Apr 15.

The Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.

Bacteria can acquire an accessory genome through the horizontal transfer of genetic elements from non-parental lineages. This leads to rapid genetic evolution allowing traits such as antibiotic resistance and virulence to spread through bacterial communities. The study of complete genomes of bacterial strains helps to understand the genomic traits associated with virulence and antibiotic resistance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215038PLOS
April 2019
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Extended Wear Bandage Contact Lenses Decrease Pain and Preserve Vision in Patients with Epidermolysis Bullosa: Case Series and Review of Literature.

Ocul Immunol Inflamm 2019 Apr 15:1-5. Epub 2019 Apr 15.

d Tufts Medical Center , Boston , MA , USA.

Purpose: To demonstrate the therapeutic benefit of extended wear bandage contact lens (BCL) use in patients with epidermolysis bullosa (EB) suffering from recurrent, painful, and slow-to-heal corneal epithelial defects.

Methods: Case reports of three patients.

Results: We report ophthalmic treatment of three pediatric patients, two with recessive dystrophic EB (RDEB) and one with junctional EB (JEB), who suffered frequently recurrent corneal abrasions and were treated with 30-day extended-wear bandage contact lenses (BCLs), replaced every month for at least 1 year. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2019.1
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http://dx.doi.org/10.1080/09273948.2019.1587472DOI Listing
April 2019
1 Read

Electroretinogram Recording in Larval Zebrafish using A Novel Cone-Shaped Sponge-tip Electrode.

J Vis Exp 2019 Mar 27(145). Epub 2019 Mar 27.

Department of Optometry and Vision Sciences, University of Melbourne;

The zebrafish (Danio rerio) is commonly used as a vertebrate model in developmental studies and is particularly suitable for visual neuroscience. For functional measurements of visual performance, electroretinography (ERG) is an ideal non-invasive method, which has been well established in higher vertebrate species. This approach is increasingly being used for examining the visual function in zebrafish, including during the early developmental larval stages. Read More

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http://dx.doi.org/10.3791/59487DOI Listing

Does Long-Term Rigid Contact Lens Wear Lead to Acquired Blepharoptosis in Chinese Eyes?

Eye Contact Lens 2019 Apr 9. Epub 2019 Apr 9.

Department of Optometry and Vision Science (B.Y., L.L.), West China School of Medicine, Sichuan University, Chengdu, China; and School of Optometry (P.C.), The Hong Kong Polytechnic University, Hong Kong, China.

Objectives: To determine whether long-term rigid contact lens wear leads to acquired blepharoptosis and whether its development is affected by lens removal methods.

Methods: Ninety rigid contact lens wearers (45 rigid gas permeable [RGP] [15-19 years old] and 45 ortho-k [15-40 years old]) who had worn lenses for at least 2 years and 45 spectacle-wearing controls (15-19 years old) were recruited. Margin reflex distance (MRD) and palpebral fissure height (PFH) were measured both subjectively and objectively, but levator function (LF) could only be measured subjectively. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000607DOI Listing
April 2019
2 Reads

The Role of Soft Contact Lens Wear on Meibomian Gland Morphology and Function.

Eye Contact Lens 2019 Apr 9. Epub 2019 Apr 9.

School of Optometry (A.D.P.), University of Alabama at Birmingham, Birmingham, AL; College of Optometry (L.A.J.-J.), The Ohio State University, Columbus, OH; JENVIS Research c/o Ernst Abbe (S.M, W.S.), University of Jena, Jena, DE; Southern College of Optometry (D.R.P), Memphis, TN; Southern California College of Optometry (J.T.K.), Marshall B Ketchum, Fullerton, CA; and Centre for Ocular Research and Education (CORE) (L.J.), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, CA.

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http://dx.doi.org/10.1097/ICL.0000000000000598DOI Listing

Orthokeratology With a New Contact Lens Design in Hyperopia: A Pilot Study.

Eye Contact Lens 2019 Apr 12. Epub 2019 Apr 12.

Group of Optics and Visual Perception (A.S.-G. and D.P.P.), Department of Optics, Pharmacology and Anatomy, University of Alicante, San Vicente del Raspeig (Alicante), Spain; Department of Optometry and Vision (L.B.-V.), Complutense University of Madrid, Madrid, Spain; and Department of Ophthalmology (D.P.P.), Vithas Medimar International Hospital, Alicante, Alicante, Spain.

Purpose: To evaluate the preliminary clinical outcomes of a new contact lens design for orthokeratology in hyperopia.

Methods: Prospective pilot study including 8 hyperopic eyes of 4 nonpresbyopic patients (24-44 years) undergoing orthokeratology with the Alexa H contact lens (Tiedra Pharmaceutical, Madrid, Spain), which is an aspheric pentacurve design. Visual, refractive, corneal topographic, and aberrometric changes were evaluated during a 1-month follow-up. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000611DOI Listing
April 2019
1 Read

Inter-visit measurement variability of conjunctival vasculature and circulation in habitual contact lens wearers and non-lens wearers.

Eye Vis (Lond) 2019 1;6:10. Epub 2019 Apr 1.

1Miller School of Medicine, Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, McKnight Building - Room 202A, Miami, FL 33136 USA.

Background: The inter-visit variation of measuring bulbar conjunctival microvasculature and microcirculation needs to be considered when the results from multiple visits are interpreted. This study examined the inter-visit variability of measuring conjunctival microvasculature and microcirculation in habitual contact lens (HCL) wearers and non-contact lens (NCL) wearers.

Methods: Twenty-eight subjects were recruited including 13 HCL wearers (10 females and 3 males; mean age ± standard deviation, 25. Read More

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http://dx.doi.org/10.1186/s40662-019-0135-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442401PMC

Bradykinin Type 1 Receptor - Inducible Nitric Oxide Synthase: A New Axis Implicated in Diabetic Retinopathy.

Front Pharmacol 2019 29;10:300. Epub 2019 Mar 29.

Department of Pharmacology and Physiology, University of Montreal, Montreal, QC, Canada.

Compelling evidence suggests a role for the inducible nitric oxide synthase, iNOS, and the bradykinin type 1 receptor (B1R) in diabetic retinopathy, including a possible control of the expression and activity of iNOS by B1R. In diabetic retina, both iNOS and B1R contribute to inflammation, oxidative stress, and vascular dysfunction. The present study investigated whether inhibition of iNOS has any impact on inflammatory/oxidative stress markers and on the B1R-iNOS expression, distribution, and action in a model of type I diabetes. Read More

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http://dx.doi.org/10.3389/fphar.2019.00300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449803PMC

A new subset of small stem cells in bovine bone marrow stromal cell populations.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Laboratory for Stem Cell and Retinal Regeneration, Institute of Stem Cell Research, Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Bone marrow stromal cells (BMSCs) are a unique population of multipotent cells that exhibit pluripotent properties to a certain extent and are significantly heterogeneous in terms of the cell population. We isolate a small cell subpopulation from bovine BMSCs, bovine small stem cells (bSSCs), and herein characterize their properties. The bSSCs are smaller in size and express nuclear Oct-4 and other pluripotency markers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28661
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http://dx.doi.org/10.1002/jcb.28661DOI Listing
April 2019
1 Read

Quantitative proteomics identifies brain acid soluble protein 1 (BASP1) as a prognostic biomarker candidate in pancreatic cancer tissue.

EBioMedicine 2019 Apr 11. Epub 2019 Apr 11.

Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden. Electronic address:

Background: Pancreatic cancer is a heterogenous disease with a poor prognosis. This study aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a mass spectrometry (MS) based proteomics approach.

Methods: Global protein sequencing of fresh frozen pancreatic cancer and healthy pancreas tissue samples was conducted by MS to discover potential protein biomarkers. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.04.008DOI Listing

μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells.

Neuroscience 2019 Apr 11. Epub 2019 Apr 11.

Dept. of Biomedical Sciences, Colorado State University, Ft. Collins, CO 80523. Electronic address:

Intrinsically photosensitive retinal ganglion cells (ipRGCs) encode light intensity and trigger reflexive responses to changes in environmental illumination. In addition to functioning as photoreceptors, ipRGCs are post-synaptic neurons in the inner retina, and there is increasing evidence that their output can be influenced by retinal neuromodulators. Here we show that opioids can modulate light-evoked ipRGC signaling, and we demonstrate that the M1, M2 and M3 types of ipRGCs are immunoreactive for μ-opioid receptors (MORs) in both mouse and rat. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.005DOI Listing

Retinal microvascular development in the first two years.

Microvasc Res 2019 Apr 11. Epub 2019 Apr 11.

Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; Health Unit, Flemish Institute for Technological Research (VITO), Mol, Belgium.

The link between in utero and early life insults and the development of chronic illness remains to be fully understood, but there is increasing data to indicate that microvasculature pathology plays an important mechanistic role. Currently available data indicate that retinal microvasculature changes are detectable in children as young as six years of age, however, there are no data for younger children. We present retinal microvasculature measurement from the first two years of life. Read More

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http://dx.doi.org/10.1016/j.mvr.2019.04.005DOI Listing

The influence of meibomian gland loss on ocular surface clinical parameters.

Cont Lens Anterior Eye 2019 Apr 10. Epub 2019 Apr 10.

Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain.

Purpose: To assess the relationship between the meibomian gland loss (MGL) and relevant ocular surface clinical parameters as well as the influence of age in this relationship.

Methods: A total of 161 participants (mean age; 42±17 years) were enrolled in this study. Infrared meibography was performed using Keratograph 5M (K5M; Oculus GmbH, Wetzlar). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13670484183106
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http://dx.doi.org/10.1016/j.clae.2019.04.004DOI Listing
April 2019
1 Read

A topographical method to quantify scleral contact lens decentration.

Cont Lens Anterior Eye 2019 Apr 10. Epub 2019 Apr 10.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Australia.

Purpose: To describe a simple method to quantify scleral contact lens decentration using over-topography captured with a Placido ring videokeratoscope, and its repeatability.

Methods: Scleral lens over-topography (E300 videokeratoscope, Medmont) was measured on 10 healthy participants following 15 min of lens settling (16.5 mm total diameter ICD miniscleral, Capricornia). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13670484183097
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http://dx.doi.org/10.1016/j.clae.2019.04.005DOI Listing
April 2019
4 Reads

A Critical Appraisal of National and International Clinical Practice Guidelines Reporting Nutritional Recommendations for Age-Related Macular Degeneration: Are Recommendations Evidence-Based?

Nutrients 2019 Apr 11;11(4). Epub 2019 Apr 11.

Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.

Eye care professionals should have access to high quality clinical practice guidelines that ideally are underpinned by evidence from robust systematic reviews of relevant research. The aim of this study was to identify clinical guidelines with recommendations pertaining to dietary modification and/or nutritional supplementation for age-related macular degeneration (AMD), and to evaluate the overall quality of the guidelines using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument. We also mapped recommendations to existing systematic review evidence. Read More

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http://dx.doi.org/10.3390/nu11040823DOI Listing

Preliminary Validation of a Food Frequency Questionnaire to Assess Long-Chain Omega-3 Fatty Acid Intake in Eye Care Practice.

Nutrients 2019 Apr 11;11(4). Epub 2019 Apr 11.

Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, 3010 Victoria, Australia.

Clinical recommendations relating to dietary omega-3 essential fatty acids (EFAs) should consider an individual's baseline intake. The time, cost, and practicality constraints of current techniques for quantifying omega-3 levels limit the feasibility of applying these methods in some settings, such as eye care practice. This preliminary validation study, involving 40 adults, sought to assess the validity of a novel questionnaire, the Clinical Omega-3 Dietary Survey (CODS), for rapidly assessing long-chain omega-3 intake. Read More

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http://dx.doi.org/10.3390/nu11040817DOI Listing

Gap effect and express saccades generation in amblyopia.

J Vis 2019 Apr;19(4):17

Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.

Amblyopia is a neurodevelopmental vision disorder that is associated with abnormal visual stimulation during early childhood. Although our knowledge regarding spatial vision deficits in amblyopic subjects is well established, the neural control of eye movements in amblyopia is yet to be explored. In the present study we have evaluated the gap effect, and for the first time (to our best knowledge), express saccades generation in amblyopic (strabismic as well as anisometropic) and age-matched control subjects. Read More

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http://dx.doi.org/10.1167/19.4.17DOI Listing

Patient-Sharing Relations in the Treatment of Diabetes and Their Implications for Health Information Exchange: Claims-Based Analysis.

JMIR Med Inform 2019 Apr 12;7(2):e12172. Epub 2019 Apr 12.

Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

Background: Health information exchange (HIE) among care providers who cooperate in the treatment of patients with diabetes mellitus (DM) has been rated as an important aspect of successful care. Patient-sharing relations among care providers permit inferences about corresponding information-sharing relations.

Objectives: This study aimed to obtain information for an effective HIE platform design to be used in DM care by analyzing patient-sharing relations among various types of care providers (ToCPs), such as hospitals, pharmacies, and different outpatient specialists, within a nationwide claims dataset of Austrian DM patients. Read More

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http://medinform.jmir.org/2019/2/e12172/
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http://dx.doi.org/10.2196/12172DOI Listing
April 2019
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Genomic and phylogenetic characterization of Shewanella xiamenensis isolated from giant grouper (Epinephelus lanceolatus) in Taiwan.

Zoonoses Public Health 2019 Apr 12. Epub 2019 Apr 12.

Department of Optometry, Shu-Zen Junior College of Medicine and Management, Kaohsiung City, Taiwan.

Shewanella xiamenensis is an emerging pathogen causing intra-abdominal infection and intestinal colonization. Epidemiologic clues suggest its role as a potential food-borne zoonotic agent. To date, four genome sequences of S. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/zph.12580
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http://dx.doi.org/10.1111/zph.12580DOI Listing
April 2019
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Lensectomy after radial keratotomy: 1-year follow-up.

Int Ophthalmol 2019 Apr 11. Epub 2019 Apr 11.

Fernández-Vega Ophthalmological Institute, Avda. Dres. Fernández-Vega 114, 33012, Oviedo, Spain.

Purpose: To report visual and refractive results in radial keratotomy (RK) patients that underwent a cataract surgery with a monofocal intraocular lens (IOL) implantation with 1 year of follow-up.

Methods: Twenty-eight eyes of 15 patients with cataract and the previous RK were included. All eyes underwent phacoemulsification and monofocal IOL implantation. Read More

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http://dx.doi.org/10.1007/s10792-019-01104-wDOI Listing

Mechanisms of neurodegeneration in a preclinical autosomal dominant retinitis pigmentosa knock-in model with a Rho mutation.

Cell Mol Life Sci 2019 Apr 11. Epub 2019 Apr 11.

Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology, and Cell Biology, Columbia University, New York, NY, 10032, USA.

D190N, a missense mutation in rhodopsin, causes photoreceptor degeneration in patients with autosomal dominant retinitis pigmentosa (adRP). Two competing hypotheses have been developed to explain why D190N rod photoreceptors degenerate: (a) defective rhodopsin trafficking prevents proteins from correctly exiting the endoplasmic reticulum, leading to their accumulation, with deleterious effects or (b) elevated mutant rhodopsin expression and unabated signaling causes excitotoxicity. A knock-in D190N mouse model was engineered to delineate the mechanism of pathogenesis. Read More

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http://dx.doi.org/10.1007/s00018-019-03090-9DOI Listing

A Case of Unilateral Phthiriasis Palpebrarum Infestation.

JAMA Ophthalmol 2019 Apr 11;137(4):e184503. Epub 2019 Apr 11.

Eye Institute and School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin, China.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.4503DOI Listing

A novel thermogel system of self-assembling peptides manipulated by enzymatic dephosphorylation.

Chem Commun (Camb) 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China.

Supramolecular hydrogels of self-assembling peptides and thermogels are very promising for biomedical applications. However, there were no thermogels of self-assembling peptides. In this study, we reported on a novel and versatile strategy to prepare thermogels of self-assembling peptides by enzyme-instructed peptide folding and self-assembly. Read More

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http://dx.doi.org/10.1039/c9cc00401gDOI Listing
April 2019
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Blocking tactile input to one finger using anaesthetic enhances touch perception and learning in other fingers.

J Exp Psychol Gen 2019 Apr;148(4):713-727

Institute of Cognitive Neuroscience, University College London.

Brain plasticity is a key mechanism for learning and recovery. A striking example of plasticity in the adult brain occurs following input loss, for example, following amputation, whereby the deprived zone is "invaded" by new representations. Although it has long been assumed that such reorganization leads to functional benefits for the invading representation, the behavioral evidence is controversial. Read More

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http://dx.doi.org/10.1037/xge0000514DOI Listing

Glasgow Outcome Scale Measures and Impact on Analysis and Results of a Randomized Clinical Trial of Severe TBI.

J Neurotrauma 2019 Apr 11. Epub 2019 Apr 11.

Baylor College of Medicine, Neurosurgery , One Baylor Plaza , Houston, Texas, United States , 77030 ;

The original unstructured Glasgow Outcome Scale (uGOS) and the newer structured interviews GOS and GOSE have been used widely as outcomes in severe traumatic brain injury (TBI) trials. We compared outcome categories (ranging from dead to good recovery) for each measure in a randomized trial of transfusion threshold and the implications of measure choice and analysis methods for the results of the trial. We planned to explore patient symptomology possibly driving any discrepancies between the patient's uGOS and GOS scores. Read More

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http://dx.doi.org/10.1089/neu.2018.5939DOI Listing
April 2019
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Simultaneous delivery of gene and chemotherapeutics via copolymeric micellar nanoparticles to overcome multiple drug resistance to promote synergistic tumor suppression.

J Biomater Appl 2019 Apr 10:885328219839254. Epub 2019 Apr 10.

5 School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China.

Combination of chemotherapy and small interfering RNA (siRNA)-based nanotherapeutics could cooperatively and effectively suppress multiple drug resistance in cancer development. Particularly, nano-delivery systems that efficiently encapsulate two or more therapeutic payloads to the tumor-targeted sites have been proven significantly. Here, we prepared a micellar nanoparticle formed by monomethoxy poly (ethylene glycol)-block-poly(ε-caprolactone)-block-poly(L-lysine)/cholesterol (mPEG-b-PCL-b-PLL/Chol, further abbr. Read More

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http://journals.sagepub.com/doi/10.1177/0885328219839254
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http://dx.doi.org/10.1177/0885328219839254DOI Listing
April 2019
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2.197 Impact Factor

Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk.

Braz J Med Biol Res 2019 Apr 8;52(4):e8217. Epub 2019 Apr 8.

Department of Refraction and Cornea, Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin, China.

The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Read More

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http://dx.doi.org/10.1590/1414-431X20198217DOI Listing

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea.

Cornea 2019 Apr 8. Epub 2019 Apr 8.

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN.

Purpose: We previously showed that cannabinoid-related GPR18 receptors are present in the murine corneal epithelium, but their function remains unknown. The related CB1 receptors regulate corneal healing, possibly via chemotaxis. We therefore examined a potential role for GPR18 in corneal epithelial chemotaxis and wound healing. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001934DOI Listing

Corneal surface wettability and tear film stability before and after scleral lens wear.

Cont Lens Anterior Eye 2019 Apr 6. Epub 2019 Apr 6.

Department of Optics II (Optometry and Vision), Faculty of Optic and Optometry, Universidad Complutense de Madrid, Madrid, Spain. Electronic address:

Purpose: The aim of this study was to evaluate the anterior surface of scleral contact lens and ocular surface wettability before and after one-month of scleral lens wear in patients with keratoconus.

Methods: Forty-nine patients with keratoconus (36.26 ± 9. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13670484183102
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http://dx.doi.org/10.1016/j.clae.2019.04.001DOI Listing
April 2019
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Transparency in the eye region of an ostracod carapace ( Macrocypridina castanea, Myodocopida).

Philos Trans A Math Phys Eng Sci 2019 Feb;377(2138):20180267

2 Structural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University , Maindy Road, Cardiff , UK.

Many myodocopid ostracods are unusual in that they have well-developed compound eyes yet must view their environment through a shell. The cypridinid Macrocypridina castanea is relatively large among ostracods (about 5-10 mm) and is a pelagic predator. This species possess highly pigmented shells with a transparent region lying just above the eye. Read More

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http://dx.doi.org/10.1098/rsta.2018.0267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335281PMC
February 2019

Estradiol potentiates inhibitory synaptic transmission in the oval bed nucleus of the striaterminalis of male and female rats.

Psychoneuroendocrinology 2019 Apr 3;106:102-110. Epub 2019 Apr 3.

Department of Biomedical and Molecular Sciences, Queen's University, Biosciences Complex, 116 Barrie street, Kingston, Ontario, K7L 3N6, Canada. Electronic address:

17ß-Estradiol (E2) is a potent neuromodulator capable of producing changes in inhibitory synaptic transmission by either changing pre-synaptic GABA release or post-synaptic GABA receptor function. Physiologically, E2 is important for energy homeostasis, influencing food consumption, body weight, adipose tissue metabolism and energy expenditure. E2 may influence energy homeostasis through estrogen receptor-rich regions such as the oval bed nucleus of the stria-terminalis (ovBNST). Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.030DOI Listing
April 2019
2 Reads