20,598 results match your criteria Optometry: Journal of the American Optometric Association [Journal]


Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection.

Ophthalmic Res 2018 Dec 6:1-5. Epub 2018 Dec 6.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu,

Purpose: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR).

Methods: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. Read More

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December 2018

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018

Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.

On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More

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December 2018
1 Read

Eye and Vision Health for Tomorrow: From Recommendations to Coordinated Action.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Indiana University School of Optometry, Bloomington.

In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue initiated by this report. In 2018, a stakeholder meeting assessed the feasibility of establishing a backbone organization, a national center that can provide technical and resource assistance regarding eye and vision health. Read More

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December 2018
1 Read

Re: Does the temperature of an artificial tear affect its comfort?

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia.

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December 2018

Impact of image averaging on wide-field choroidal thickness measurements using enhanced-depth imaging optical coherence tomography.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.

Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More

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December 2018

Comparing spectacle and toric contact lens prescribing trends for astigmatism.

Clin Optom (Auckl) 2018 8;10:119-127. Epub 2018 Nov 8.

DAVICH Optical Chain, Daechi-dong, Gangnam-gu, Seoul, South Korea.

Background: The purpose of this study is to investigate and compare spectacle and contact lens (CL) prescription trends, with an emphasis on astigmatic refractive error prescribing differences for patients who purchase spectacles or CLs in South Korea.

Methods: A retrospective study of patient records of a major optical chain in South Korea was conducted. De-identified data of age, gender, power of prescribed spectacles and/or CLs were extracted from the practice database. Read More

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November 2018

Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt-β-catenin pathway.

Onco Targets Ther 2018 9;11:7987-7999. Epub 2018 Nov 9.

School of Laboratory Medicine and Life Science, Wenzhou Medical University, Zhejiang, People's Republic of China,

Background: Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal cancer cell lines and its molecular mechanism.

Methods: Lupeol was assessed for its anticancer effect using two human colorectal cancer cell lines: SW480 and HCT116. Read More

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November 2018
1 Read

A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Vitreous Retina Macula Consultants of New York, New York, NY, USA.

Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).

Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More

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December 2018

2018 American Academy of Optometry Ocular Photography Contest.

Authors:

Optom Vis Sci 2018 Dec;95(12):1162-1165

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December 2018

Optometry and Vision Science: 2018 Year End Review.

Authors:
Michael Twa

Optom Vis Sci 2018 Dec;95(12):1087

Editor in Chief Birmingham, AL.

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December 2018

Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation.

J Mater Sci Mater Med 2018 Nov 30;29(12):182. Epub 2018 Nov 30.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia.

3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. Read More

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November 2018
3 Reads

Data on differentially expressed proteins in retinal emmetropization process in guinea pig using integrated SWATH-based and targeted-based proteomics.

Data Brief 2018 Dec 31;21:1750-1755. Epub 2018 Aug 31.

Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, the Hong Kong Polytechnic University, Kowloon, Hong Kong.

Myopia is generally regarded as a failure of normal emmetropization process, however, its underlying molecular mechanisms are unclear. Retinal protein profile changes using integrated SWATH and MRM-HR MS were studied in guinea pigs at 3- and 21-days of age, where the axial elongation was significantly detected. Differential proteins expressions were identified, and related to pathways which are important in postnatal development in retina, proliferation, breakdown of glycogen-energy and visual phototransduction. Read More

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December 2018

Optical Rehabilitation of a Patient with Keratoconus and Nystagmus.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):183-189

Kentucky College of Optometry, University of Pikeville, Pikeville, KY, USA.

Keratoconus is a progressive corneal disease characterized by bilateral yet usually asymmetric thinning of the cornea with an onset typically in teenage years. While it often presents as an isolated condition, keratoconus may also be associated with many systemic and/or ocular diseases, such as connective tissue and chromosomal disorders. Its association with nystagmus has been described in Leber's congenital amaurosis, where patients also exhibit abnormal pupillary responses, early-onset retinal dystrophy, mental developmental delays, and eventual blindness. Read More

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January 2018
1 Read

The Effect of Intravitreal Bevacizumab on Central Serous Chorioretinopathy.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):176-182

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

The aim of this study was to investigate the efficacy of Intravitreal Injection of Bevacizumab (IVB) in patients with Central Serous Chorioretinopathy (CSC) compared to the control group, after four months of injection. In this study, 30 eyes of 30 patients with CSC, who were in the age range of 23 to 50 years old (70% male subject) were included. Eligible patients were randomly allocated to the intervention (n = 15) and control groups (n = 15). Read More

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January 2018

A case of choroidal osteoma in a 17-year-old female.

Oman J Ophthalmol 2018 Sep-Dec;11(3):267-269

Department of Optometry, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.

A 17-year female was referred for complaints of blurring and decreased vision in the right eye. The patient underwent fundus examination, optical coherence tomography and B-scan ultrasonography. A well-defined, yellow-orange colored lesion was present in the posterior pole. Read More

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December 2018

Myopia, the challenge of ophthalmology and its worldwide «explosive epidemic».

Arch Soc Esp Oftalmol 2018 Nov 27. Epub 2018 Nov 27.

Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, San Vicente del Raspeig, Alicante, España.

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November 2018

Determination of central corneal clearance in scleral lenses with an optical biometer and agreement with subjective evaluation.

Cont Lens Anterior Eye 2018 Nov 27. Epub 2018 Nov 27.

Clinical & Experimental Optometry Research Lab (CEORLab), Center of Physics. University of Minho, Braga, Portugal.

Purpose: To compare three methods to measure center corneal clearance (CCC) during scleral lens wear: subjective (slit lamp), image processed (ImageJ) and with an optic biometer. The optic biometer technique was validated in comparison to an OCT in the first part of the study.

Methods: Twenty-two eyes (11 subjects) with healthy corneas were recruited. Read More

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November 2018

Automated 2D-3D quantitative analysis of corneal graft detachment post DSAEK based on AS-OCT images.

Comput Methods Programs Biomed 2018 Dec 9;167:1-12. Epub 2018 Oct 9.

Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034, India.

Background And Objective: In current ophthalmological practices, assessment of graft condition post Descemet's stripping automated endothelial keratoplasty (DSAEK) is performed qualitatively using few (four) anterior-segment optical coherence tomography (AS-OCT) radial B-scans. From those scans, clinicians need to mentally synthesize the graft in 3D, and estimate its overall condition. In contrast, quantitative representation of 360° thickness profile would facilitate better visualization of graft condition, and hence medical decision making. Read More

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December 2018

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5752-5761

University of Houston College of Optometry, Houston, Texas, United States.

Purpose: The purpose of this study was to explore differences in genotype, ocular surface microbiome, tear inflammatory markers, and environmental and behavioral exposures in soft contact lens (SCL) wearers with and without a history of corneal infiltrative events (CIEs).

Methods: Nine SCL wearers with a recent CIE and nine age-, sex-, and SCL material- and modality-matched controls were enrolled. The Contact Lens Risk Survey, slit-lamp examination data, basal tears, conjunctival microbial cultures, and peripheral blood samples were collected. Read More

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December 2018
2 Reads

Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study.

Soft Matter 2018 Dec 5. Epub 2018 Dec 5.

KTH Royal Institute of Technology, Department of Chemistry, Division of Surface and Corrosion Science, SE-100 44 Stockholm, Sweden.

Propofol is an amphiphilic small molecule that strongly influences the function of cell membranes, yet data regarding interfacial properties of propofol remain scarce. Here we consider propofol adsorption at the air/water interface as elucidated by means of vibrational sum frequency spectroscopy (VSFS), neutron reflectometry (NR), and surface tensiometry. VSFS data show that propofol adsorbed at the air/water interface interacts with water strongly in terms of hydrogen bonding and weakly in the proximity of the hydrocarbon parts of the molecule. Read More

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December 2018
1 Read

Genomic full-length sequence of the HLA-A*24:20:01:01 allele, identified by cloning and sequencing.

HLA 2018 Dec 5. Epub 2018 Dec 5.

Shenzhen Eye Hospital Affiliated to Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen, P. R. China.

Genomic full length sequence of HLA-A*24:20:01:01, was identified by cloning and sequencing from a Chinese donor. This article is protected by copyright. All rights reserved. Read More

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December 2018
2 Reads

IL-27 Signaling Deficiency Develops Th17-enhanced Th2-dominant Inflammation in Murine Allergic Conjunctivitis Model.

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.

Background: While most studies focus on pro-allergic cytokines, the protective role of immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was to explore a novel anti-inflammatory role and cellular/molecular mechanism of IL-27 in allergic inflammation.

Methods: A murine model of experimental allergic conjunctivitis (EAC) was induced in BALB/c, C57BL/6 or IL-27Rα deficient (WSX-1 ) mice by short ragweed pollen, with untreated or PBS-treated mice as controls. Read More

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December 2018

Workshop, Cost-Effective and Streamlined Fabrications of Re-Usable World-To-Chip Connectors for Handling Sample of Limited Volume and for Assembling Chip Array.

Sensors (Basel) 2018 Dec 1;18(12). Epub 2018 Dec 1.

Department of Biochemistry and Molecular Cell Biology, Taipei Medical University, Taipei City 110, Taiwan.

The world-to-chip interface is an essential yet intriguing part of making and employing microfluidic devices. A user-friendly connector could be expensive or difficult to make. We fabricated two ports of microfluidic chips with easily available materials including Teflon blocks, double adhesive films, coverslips, and transparency films. Read More

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December 2018

MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.

Exp Cell Res 2018 Dec 1. Epub 2018 Dec 1.

School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, Wenzhou, Zhejiang, 325027, P.R.China. Electronic address:

Retinal pigment epithelial cells (RPEs), a pigmented cell layer in the outer retina, are constantly exposed to photo-oxidative stress. Autophagy relieves the stress by removing oxidative protein adducts, protein aggregates, and damaged mitochondria. We previously found that miR-29 is downregulated in choroid/RPE tissue in a model of exudative age-related macular degeneration (AMD), suggesting that miR-29 deficiency may contribute to autophagy inhibition and AMD progression. Read More

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December 2018
1 Read

An Investigation of the Role of Macular Pigment in Attenuating Photostress through Comparison between Blue and Green Photostress Recovery Times.

Curr Eye Res 2018 Dec 4. Epub 2018 Dec 4.

a Department of Materials Science , University of Milano Bicocca , Milan , Italy.

Purpose: Photostress recovery time (PSRT) is the time required for the macula to return to its normal functioning after the bleaching of cone photopigments due to light exposure, usually white. This work investigates the role of macular pigment (MP) as an optical filter which attenuates photostress by analyses of PSRT at different wavelengths.

Methods: Thirty-nine subjects (19-28 years) were exposed to blue/green photostress varying in irradiance. Read More

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December 2018

Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro.

Mediators Inflamm 2018 29;2018:2574067. Epub 2018 Oct 29.

Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, China.

Uveitis is a serious eye disease that usually damages young adult's health. MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate messenger RNA (mRNA) expression. It is predicted that rno-miR-30b-5p can regulate the expressions of interleukin-10 (IL-10) and Toll-like receptor 4 (TLR4). Read More

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October 2018

Why are there gender inequalities in visual impairment?

Eur J Public Health 2018 Nov 29. Epub 2018 Nov 29.

Agència de Salut Pública de Barcelona, Barcelona, Spain.

Background: In high-income countries, the prevalence of blindness and visual impairment is higher among women, regardless of age although the mechanisms that produce these gender inequalities are not well understood. The objectives of this study were to analyse gender inequalities in the prevalence of blindness and visual impairment, age of onset, diagnosed and undiagnosed status and related eye diseases among visually impaired individuals.

Methods: Data were obtained from the 2008 Spanish Survey on 'Disability, Personal Autonomy and Dependency Situations' (n = 213 626) participants 360 blind (160 men and 200 women), and 5560 with some visual impairment (2025 men and 3535 women). Read More

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November 2018

[Spectral correction of vision and electrophysiological measurements of the eye].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):231-237

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Spectral light filters - glasses and intraocular lenses - are widely used in ophthalmology and optometry. Light filters help increase vision clarity, contrast and quality in patients with ocular media opacities and other eye diseases. The article describes the types of light filters and the methods of their clinical application, and presents data on the influence of intra- and extraocular spectral correction on electrophysiological parameters of the retina. Read More

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January 2018
2 Reads

Sexual and urinary function following anterior lumbar surgery in females.

Neurourol Urodyn 2018 Nov 29. Epub 2018 Nov 29.

Neuro- and Spine Center, Hirslanden Klinik St. Anna, Lucerne, Switzerland.

Aims: Anterior lumbar interbody fusion procedures (ALIF) and total disc replacement (TDR) with anterior exposure of the lumbar spine entail a risk of a vascular injury and dysfunction of the sympathetic and parasympathetic nerves due to disturbance of the inferior and superior hypogastric plexus. While retrograde ejaculation is a known complication of the anterior spinal approach in males, post-operative sexual as well as urinary function in females has not yet been thoroughly investigated and was hence the aim of this study.

Methods: Fifteen female patients documented their sexual and urinary function preoperatively, 3 months and 6 months postoperatively, using the validated questionnaires FSFI (Female Sexual Function Index) and ICIQ (International Consultation of Incontinence Questionnaire). Read More

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November 2018
4 Reads

Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE-19 cells.

Environ Toxicol 2018 Nov 30. Epub 2018 Nov 30.

Department of Optometry, Asia University, Taichung, Taiwan.

Kaempferol is a flavonoid with anticancer and anti-metastasis activity in different cancer-cell lines. However, the underlying mechanisms by which kaempferol acts on human retinal pigment epithelial (ARPE-19) cells remain unclear. In this study, we demonstrated that kaempferol inhibited migration and invasion in ARPE-19 cells at non-toxic dosages. Read More

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November 2018

Relating optical coherence tomography to visual fields in glaucoma: structure-function mapping, limitations and future applications.

Clin Exp Optom 2018 Nov 29. Epub 2018 Nov 29.

Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure-function map. In this review, the structure-function mapping methods in clinical use are discussed. Read More

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November 2018

Clinical and Mutation Analysis of Patients with Best Vitelliform Macular Dystrophy or Autosomal Recessive Bestrophinopathy in Chinese Population.

Biomed Res Int 2018 18;2018:4582816. Epub 2018 Oct 18.

Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing, China.

Mutations in the gene usually cause bestrophinopathies, such as the rare progressive diseases Best vitelliform macular dystrophy (BVMD) and autosomal recessive bestrophinopathy (ARB). This study aimed to investigate the clinical characteristics of patients with BVMD or ARB carrying mutations. A total of 12 probands including 9 patients with a clinical diagnosis of BVMD and 3 patients with a clinical diagnosis of ARB were recruited for genetics analysis. Read More

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October 2018

Unique presentation of congenital cataract concurrent with microcornea, microphthalmia plus posterior capsule defect in monozygotic twins caused by a novel GJA8 mutation.

Eye (Lond) 2018 Nov 29. Epub 2018 Nov 29.

The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, 325027, Wenzhou, China.

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November 2018

Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke.

PLoS One 2018 29;13(11):e0207348. Epub 2018 Nov 29.

Department of Clinical Chemistry, County Hospital of Kalmar, Kalmar, Sweden.

Background: The major cause of ischemic stroke is unstable or thrombogenic atherosclerotic plaques. Vascular calcification, a process that appears crucial for plaque stability, shares common features with bone formation. Many bone turnover proteins exhibit metabolic properties, but the evidence is conflicting regarding their possible involvement in vascular disease. Read More

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November 2018
3 Reads

Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma.

JAMA Ophthalmol 2018 Nov 29. Epub 2018 Nov 29.

Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, Illinois.

Importance: Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear.

Objective: To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma.

Design, Setting, And Participants: This case series study was a retrospective medical record review of patients who received a diagnosis of vitreoretinal lymphoma at the Department of Ophthalmology at Northwestern University between July 2014 and January 2016. Read More

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November 2018
2 Reads

Prevalence of Primary Glaucoma as Diagnosed by Study Optometrists of L. V. Prasad eye Institute - Glaucoma Epidemiology and Molecular Genetics Study.

Ophthalmic Epidemiol 2018 Nov 29:1-5. Epub 2018 Nov 29.

d School of Optometry and Vision Science , UNSW , Sydney , Australia.

Purpose: To report the prevalence of primary glaucoma as identified by study optometrists of the L. V. Prasad Eye Institute - Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). Read More

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November 2018

Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family.

Front Physiol 2018 14;9:1591. Epub 2018 Nov 14.

Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile.

Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental alterations in the children of preeclamptic pregnancies result from impaired angiogenesis. Read More

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November 2018

MicroRNA-9 inhibits retinal neovascularization in rats with diabetic retinopathy by targeting vascular endothelial growth factor A.

Authors:
Wen-Lan Liu

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Optometry Education & Research Office, College of Medical Technology, Xi'an Medical University, Xi'an, China.

Diabetic retinopathy (DR) is a leading cause of adult visual impairment and loss. This study aims to explore the effects of microRNA-9 (miR-9) on retinal neovascularization during DR by targeting the vascular endothelial growth factor A (VEGFA). DR rat models were successfully established. Read More

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November 2018

Anti-saccades predict cognitive functions in older adults and patients with Parkinson's disease.

PLoS One 2018 28;13(11):e0207589. Epub 2018 Nov 28.

School of Optometry, University of Montreal, Montreal, Quebec, Canada.

A major component of cognitive control is the ability to act flexibly in the environment by either behaving automatically or inhibiting an automatic behaviour. The interleaved pro/anti-saccade task measures cognitive control because the task relies on one's abilities to switch flexibly between pro and anti-saccades, and inhibit automatic saccades during anti-saccade trials. Decline in cognitive control occurs during aging or neurological illnesses such as Parkinson's disease (PD), and indicates decline in other cognitive abilities, such as memory. Read More

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November 2018

A study of the effect of X-ray irradiation on the structure of Narafilcon A biopolymer soft contact lenses.

Polim Med 2018 Jan-Jun;48(1):11-16

Institute of Physics, Faculty of Mathematics and Natural Sciences, Jan Dlugosz University in Czestochowa, Poland.

Background: The effects of external factors such as X-ray irradiation on the structure and physical properties of contact lenses are very important for both the patients using contact lenses and medical personnel.

Objectives: The aim of the study was to investigate the effect of X-rays on the structure of Narafilcon A silicone-hydrogel contact lenses.

Material And Methods: In order to study the structural changes caused by X-rays in Narafilcon A polymer contact lenses, the following spectroscopy methods were used: positron annihilation lifetime spectroscopy (PALS), Fourier transform middle infrared spectroscopy (FTIR) and Raman spectroscopy (RS). Read More

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November 2018

TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells.

Front Pharmacol 2018 13;9:1234. Epub 2018 Nov 13.

Klinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Humboldt-Universität zu Berlin, Berlin, Germany.

In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-TAM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells. We compare here the effects of TRPM8 activation on VEGF-induced transactivation of TRPV1 in an UM cell line (92. Read More

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November 2018

Can Blood Oxygenation Level Dependent Functional Magnetic Resonance Imaging Be Used Accurately to Compare Older and Younger Populations? A Mini Literature Review.

Front Aging Neurosci 2018 13;10:371. Epub 2018 Nov 13.

Cardiff University Brain Imaging Research Center, School of Psychology, Cardiff University, Cardiff, United Kingdom.

A wealth of research has investigated the aging brain using blood oxygenation level dependent functional MRI [Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI)]. However, many studies do not consider the aging of the cerebrovascular system, which can influence the BOLD signal independently from neural activity, limiting what can be inferred when comparing age groups. Here, we discuss the ways in which the aging neurovascular system can impact BOLD fMRI, the consequences for age-group comparisons and possible strategies for mitigation. Read More

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November 2018

Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents.

Bioorg Med Chem 2018 Nov 22. Epub 2018 Nov 22.

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China. Electronic address:

A novel scaffold of arylpiperazine derivatives was discovered as potent androgen receptor (AR) antagonist through rational drug designation based on our pre-work, leading to the discovery of a series of new antiproliferative compounds. Compounds 10, 16, 27, 29 and 31 exhibited relatively strong antagonistic potency against AR and exhibited potent AR binding affinities, while compounds 5, 6, 10, 14, 16, 19, 21, 27 and 31 exhibited strong cytotoxic activities against LNCaP cells (AR-rich) as well as also displayed the higher activities than finasteride toward PC-3 (AR-deficient) and DU145 (AR-deficient). Docking study suggested that the most potent antagonist 16 mainly bind to AR ligand binding pocket (LBP) site through hydrogen bonding interactions. Read More

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November 2018

Risk factors for paravalvular leak after transcatheter aortic valve replacement.

J Thorac Cardiovasc Surg 2018 Sep 27. Epub 2018 Sep 27.

Department of Cardiac Surgery, Cardiovascular Center, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.

Objective: To assess risk factors for paravalvular leak (PVL) after transcatheter aortic valve implantation in a large single-center cohort, including measurement of aortic valve calcification using a reproducible method.

Methods: We retrospectively analyzed preoperative contrast-enhanced multidetector computed tomography scans of patients who underwent transcatheter aortic valve implantation in our center between 2009 and 2016. Calcium volume was calculated for each aortic cusp in the aortic valve, left ventricular outflow tract, and device landing zone. Read More

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September 2018

Association of Microaneurysms on Adaptive Optics Scanning Laser Ophthalmoscopy With Surrounding Neuroretinal Pathology and Visual Function in Diabetes.

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5633-5640

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, United States.

Purpose: We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT).

Methods: Diabetic participants underwent VA testing and AOSLO and SDOCT imaging of MAs. AOSLO images were graded for MA dimension, wall hyperreflectivity (WH), intraluminal hyperreflectivity (IH), and perfusion pattern. Read More

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November 2018

Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern.

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5579-5588

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Purpose: We demonstrate segmentation and mapping of corneal layers (epithelium, Bowman's layer, and stroma) across the entire cornea (limbus to limbus), using additional contrast provided by polarization-sensitive optical coherence tomography (PS-OCT) and analyze the reproducibility of the procedure.

Methods: A custom built PS-OCT system operating at 1045 nm central wavelength with conical scanning was used for image acquisition. Conical scanning allows for almost perpendicular beam incidence on the corneal surface and provides good signal quality over the entire field of view. Read More

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November 2018
3 Reads

Measuring the Contrast Sensitivity Function Using the qCSF Method With 10 Digits.

Transl Vis Sci Technol 2018 Nov 14;7(6). Epub 2018 Nov 14.

School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: The Bayesian adaptive quick contrast sensitivity function (qCSF) method with a 10-letter identification task provides an efficient CSF assessment. However, large populations are unfamiliar with letters and cannot benefit from this test. To overcome the barrier, we conducted this study. Read More

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November 2018

Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells.

Trends Biochem Sci 2018 Nov 23. Epub 2018 Nov 23.

Vision Science Program, School of Optometry, Infectious Disease and Immunity Program, University of California Berkeley, Berkeley, CA 94720, USA. Electronic address:

Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for leukotriene B (LTB), prostaglandin E (PGE), and SPMs are expressed on lymphocytes. Read More

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November 2018

Improving eye care in residential aged care facilities using the Residential Ocular Care (ROC) model: study protocol for a multicentered, prospective, customized, and cluster randomized controlled trial in Australia.

Trials 2018 Nov 26;19(1):650. Epub 2018 Nov 26.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Level 7, 32 Gisborne Street, East Melbourne, VIC, 3002, Australia.

Background: Older adults in residential aged care facilities have unnecessarily high levels of vision impairment (VI) which are largely treatable or correctable. However, no current comprehensive eye health service model exists in this setting in Australia. We aimed to determine the clinical, person-centered, and economic effectiveness of a novel eye care model, the Residential Ocular Care (ROC). Read More

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November 2018
1 Read