665,939 results match your criteria Optic Plus [Journal]


Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):685-693

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects.

Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. Read More

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http://dx.doi.org/10.1167/iovs.18-25864DOI Listing
February 2019

Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):677-684

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Purpose: To investigate the effect of trabeculectomy on the waveform changes of laser speckle flowgraphy (LSFG) in the optic nerve head (ONH) in patients with glaucoma.

Methods: Forty-eight eyes of 48 patients with open angle glaucoma were included in this prospective study. LSFG was performed before and 1, 3, and 6 months after trabeculectomy. Read More

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http://dx.doi.org/10.1167/iovs.18-25694DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):650-660

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: DNA methylation is a key epigenetic modification involved in various biological processes and diseases. Corneal epithelial wound healing (CEWH) is essential for restoring corneal integrity and transparency after injury. However, the role of DNA methylation in CEWH remains elusive. Read More

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http://dx.doi.org/10.1167/iovs.18-25443DOI Listing
February 2019

Brain stem death - an overview.

Med Leg J 2019 Feb 20:25817218822008. Epub 2019 Feb 20.

2 Department of Forensic Medicine, Kasturba Medical College (affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, India), Mangalore, India.

The concept of brain death has been a very intriguing topic and has taken many forms over the years. Brain stem death is a complex state of inactivity defined by the loss of reflexes of the pathways that pass through the brain stem, the 'shaft' of the brain which links the spinal cord to the cerebral cortex and the cerebellum where there is apnoea, loss of eye movement and pain sensation. There are many criteria, based on which a person can be said to be brain dead. Read More

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http://dx.doi.org/10.1177/0025817218822008DOI Listing
February 2019

Planning Face, Hand, and Leg Movements: Anatomical Constraints on Preparatory Inhibition.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Psychology, UC Berkeley.

Motor-evoked potentials (MEPs), elicited by Transcranial Magnetic Stimulation (TMS) over the motor cortex, are reduced during the preparatory period in delayed response tasks. Here we examine how MEP suppression varies as a function of the anatomical organization of the motor cortex. MEPs were recorded from a left index muscle while participants prepared a hand or leg movement in Experiment 1, or prepared an eye or mouth movement in Experiment 2. Read More

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http://dx.doi.org/10.1152/jn.00711.2018DOI Listing
February 2019

Increased preparation time reduces, but does not abolish, action history bias of saccadic eye movements.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

School of Human Movement Studies, The University of Queensland, Australia.

The characteristics of movements are strongly history-dependent. Marinovic et al. (2017a) showed that past experience influences the execution of limb movements through a combination of temporally-stable processes that are strictly use-dependent, and dynamically-evolving and context-dependent processes that reflect prediction of future actions. Read More

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http://dx.doi.org/10.1152/jn.00512.2018DOI Listing
February 2019

Ocular dialysis disequilibrium-Management of intraocular pressure during hemodialysis of open angle glaucoma: A case report and review of the literature.

Hemodial Int 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

It has been shown that patients with end-stage renal disease (ESRD) have an increased risk for changes in intraocular pressure during hemodialysis, or ocular dialysis disequilibrium which can cause pain or discomfort during treatment and lead to decreased vision over time. This is a case of an elderly male with ESRD who was having headaches, nausea, and eye pain during hemodialysis due to increased intraocular pressures. Using a higher sodium prescription resolved his symptoms and normalized his intraocular pressures. Read More

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http://dx.doi.org/10.1111/hdi.12718DOI Listing
February 2019

Mercaptopyridine-Functionalized Au Nanoparticles for Fiber-Optic Surface Plasmon Resonance Hg2+ Sensing.

ACS Sens 2019 Feb 20. Epub 2019 Feb 20.

As a highly toxic heavy metal ion, divalent mercuric ion (Hg2+) is one of the most widely diffused and hazardous environmental pollutants. In this paper, a simple, portable, and inexpensive fiber-optic sensor based on surface plasmon resonance (SPR) effect was developed for Hg2+ detection, which takes advantage of 4-mercaptopyridine (4-MPY) functionalized Au nanoparticles (Au NPs/4-MPY) as a signal amplification tag. Based on the coordination between Hg2+ and nitrogen in the pyridine moiety, we developed the sensor by self-assembling 4-MPY on Au film surfaces to capture Hg2+, and then introducing Au NPs/4-MPY to generate a plasmonic coupling structure with the configuration of nanoparticle-on-mirror. Read More

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http://dx.doi.org/10.1021/acssensors.8b01558DOI Listing
February 2019

Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in essential tremor.

Ideggyogy Sz 2019 Jan;72(1-2):33-38

Bezmialem Vakif University Hospital, Department of Neurology, İstanbul, Turkey.

Background And Purpose: Although essential tremor (ET) is the most common cause of tremor, the pathology and underlying mechanisms have not fully understood yet. In addition to kinetic tremor, patients may present several types of tremor, gait ataxia, hearing deficits and eye movement abnormalities. Non-motor symptoms and signs have also added to definition of ET. Read More

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http://dx.doi.org/10.18071/https://doi.org/10.18071/isz.72.0033DOI Listing
January 2019

Demographic and nap-related variance of the MSLT: results from 2,498 suspected hypersomnia patients: Clinical MSLT variance.

Sleep Med 2018 Dec 30;55:115-123. Epub 2018 Dec 30.

SleepMed, Inc. Columbia, SC, USA; The University of South Carolina Medical School, Columbia, SC, USA; Bogan Sleep Consultants, LLC, Columbia, SC, USA.

Objective: The purpose of this study was to enhance our understanding of clinical trends in sleep and rapid eye movement (REM) propensity on the multiple sleep latency test (MSLT). Demographic variables of interest included early childhood/advanced age, gender, race, and REM-suppressant use.

Methods: Nocturnal sleep studies and 5-nap MSLTs were retrieved from a large repository of deidentified studies from various US sleep clinics between 2007 and 2015. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.013DOI Listing
December 2018

Phase of the menstrual cycle affects engagement of attention with emotional images.

Psychoneuroendocrinology 2019 Feb 12;104:25-32. Epub 2019 Feb 12.

Jagiellonian University, Institute of Psychology, Psychophysiology Lab, Poland. Electronic address:

Changes that occur during the menstrual cycle affect various aspects of behavior, cognition, and emotion. Here, we focused on potential differences between early follicular and midluteal phases in the way women process images of behaviorally relevant content categories: children, threat, disgust, erotic scenes, low- and high-calorie food. Using eye-tracking, we examined women's engagement of attention in the key region of each image in a free-viewing condition. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.02.009DOI Listing
February 2019

Student nurses' career motivation toward gerontological nursing: A longitudinal study.

Nurse Educ Today 2019 Feb 6;76:165-171. Epub 2019 Feb 6.

School of Nursing, Shandong University, Jinan, Shandong, China. Electronic address:

Background: The intensity of student nurses' motivation toward a certain career can influence their behaviors for career choice and decision making. However, little is known about the career motivation among student nurses toward gerontological nursing and their influencing factors.

Objectives: The objectives of this study were to examine student nurses' career motivation toward gerontological nursing and to explore potential predictors using Bandura's reciprocal determinism. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.028DOI Listing
February 2019

Pharyngeal flap using carotid artery mobilization in 22q11.2 deletion syndrome with velopharyngeal insufficiency.

Int J Pediatr Otorhinolaryngol 2019 Feb 13;120:130-133. Epub 2019 Feb 13.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA. Electronic address:

Introduction: 22q11.2 deletion syndrome is the most common microdeletion syndrome in children. Many patients with this disease develop craniofacial defects including cleft palate, bifid uvula, and velopharyngeal insufficiency. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.010DOI Listing
February 2019

Structure, dissolution, and plant uptake of ferrous/zinc phosphates.

Chemosphere 2019 Feb 12;223:310-318. Epub 2019 Feb 12.

National Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathum Thani, 12120, Thailand; AFRS(T), The Royal Society of Thailand, Sanam Sueapa, Dusit, Bangkok, 10300, Thailand. Electronic address:

Development of slow release fertilizers by tuning dissolution kinetics can reduce the environmental impact of (micro) nutrients added to crops. Mixed metal compounds may have different dissolution kinetics and plant uptake than single metal compounds. In this study, mixed Fe(II)/Zn(II) phosphates (0-100 at% Zn) were prepared by aqueous precipitation and their structural characteristics and dissolution kinetics in a sand column were measured as model for divalent metal and phosphate release in soil. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.024DOI Listing
February 2019

A comparative study on clinical features of anterior ischemic optic neuropathy and idiopathic optic neuritis.

Minerva Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Opthalmology, Shanxi Provincial People's Hospital, Taiyuan, China.

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http://dx.doi.org/10.23736/S0026-4806.19.05976-7DOI Listing
February 2019

What's Love Got to do with it? Marital status and survival of head and neck cancer.

Eur J Cancer Care (Engl) 2019 Feb 19:e13022. Epub 2019 Feb 19.

Department of Otolaryngology, The Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

Objective: To determine whether marital status independently predicts survival in a head and neck cancer (HNC) survivor population.

Methods: In this retrospective cohort study, we analysed data from 460 adult patients (59.31 ± 11. Read More

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http://dx.doi.org/10.1111/ecc.13022DOI Listing
February 2019

Modeling of inflicted head injury by shaking trauma in children: what can we learn? : Part II: A systematic review of mathematical and physical models.

Forensic Sci Med Pathol 2019 Feb 20. Epub 2019 Feb 20.

Department of BioMechanical Engineering, Faculty of Mechanical, Maritime & Materials Engineering, Delft University of Technology, Mekelweg 2, 2628, CD, Delft, the Netherlands.

Various types of complex biomechanical models have been published in the literature to better understand processes related to inflicted head injury by shaking trauma (IHI-ST) in infants. In this systematic review, a comprehensive overview of these models is provided. A systematic review was performed in MEDLINE and Scopus for articles using physical (e. Read More

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http://dx.doi.org/10.1007/s12024-019-00093-7DOI Listing
February 2019

Intracameral Delivery of AAV to Corneal Endothelium for Expression of Secretory Proteins.

Methods Mol Biol 2019 ;1950:263-270

Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland.

AAV9 drives gene expression in a highly selective manner within the corneal endothelium of mice following intracameral inoculation into the anterior chamber of the eye. In principle, this allows genes encoding protein constituents of the secretome (representing up to 20% of the human proteome) to be delivered directly into the aqueous humor. From here the secreted protein moves with the natural flow of the aqueous humor via a pressure gradient and is directed toward the outflow tissues. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_15DOI Listing
January 2019

Peripheral AAV Injection for Retrograde Transduction of Dorsal Root and Trigeminal Ganglia.

Methods Mol Biol 2019 ;1950:237-247

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Adeno-associated Virus (AAV) vectors are useful vehicles for delivering transgenes to a number of different tissues and organs in vivo. To date, most of these applications deliver the vectors to their target by either infusion into the bloodstream or direct injection into the target tissue. Recently there has been progress in delivering AAV vectors to neurons of the peripheral nervous system (PNS) following application of vectors to the peripheral epithelium, such as the skin or eye. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_13DOI Listing
January 2019

Use of AAV Vectors for CRISPR-Mediated In Vivo Genome Editing in the Retina.

Methods Mol Biol 2019 ;1950:123-139

Ocular Gene Therapy Core, National Eye Institute, NIH, Bethesda, MD, USA.

Degenerative retinal diseases such as retinitis pigmentosa (RP) and Leber's congenital amaurosis (LCA) may lead to blindness without effective treatment. With the rapid advancement of the CRISPR/Cas9 genome editing technology, in vivo application of CRISPR/Cas9 holds immense potential for treatment of these diseases. Adeno-associated virus (AAV) vectors are an ideal gene transfer tool for delivery of CRISPR components to the retina. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_7DOI Listing
January 2019

Quantitative and Digital Droplet-Based AAV Genome Titration.

Methods Mol Biol 2019 ;1950:51-83

Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

The adeno-associated viral vector (AAV) platform has developed into a primary modality for efficient in vivo, and in more limited settings, in vitro or ex vivo gene transfer. Its applications range from a tool for experimental purposes to preclinical and clinical gene therapy. The ability to accurately and reproducibly quantify vector concentration is critical for any of these applications. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_4DOI Listing
January 2019

Correction to: In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits.

Ophthalmol Ther 2019 Feb 19. Epub 2019 Feb 19.

Sun Pharmaceutical Industries, Inc., Princeton, NJ, USA.

In the original publication, units were incorrectly published in the results section as micrograms (µg/mL). Read More

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http://dx.doi.org/10.1007/s40123-019-0172-zDOI Listing
February 2019

Tear-film-oriented diagnosis for dry eye.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Optics and Spectroscopy, Faculty of Physics, St. Kliment Ohridski University of Sofia, Sofia, Bulgaria.

Tear-film (TF) stability protects the ocular surface epithelium from desiccation and is ensured via cooperation between the ocular surface components including constituents of the TF and ocular surface epithelium. Thus, when those components are insufficient or impaired, the TF breakup that initiates dry eye occurs. Recently, new, commercially available eye drops have appeared in Japan that enable TF stabilization via targeted supplementation of deficient ocular surface components. Read More

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http://dx.doi.org/10.1007/s10384-018-00645-4DOI Listing
February 2019

Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.

Purpose: To examine the effects of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy (BK).

Study Design: Retrospective case series METHODS: Consecutive patients with BK who did not wish to receive corneal transplantation and were treated with 0.1% betamethasone eyedrops were included. Read More

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http://dx.doi.org/10.1007/s10384-019-00658-7DOI Listing
February 2019

Prediction of corneal curvature radius after pterygium surgery using anterior segment optical coherence tomography.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka City, Fukuoka, 812-0011, Japan.

Purpose: To investigate the validity of a multiple regression equation to predict postoperative corneal curvature radius (K) in simultaneous cataract and pterygium surgery using preoperative factors, including preoperative K.

Study Design: Retrospective study.

Methods: Seventy eyes of 58 patients who had undergone initial pterygium removal at the Hayashi Eye Hospital between June 2014 and December 2017 were included in this study. Read More

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http://dx.doi.org/10.1007/s10384-019-00654-xDOI Listing
February 2019

An investigation of the ocular toxic effects of levetiracetam therapy in children with epilepsy.

Childs Nerv Syst 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Medicine, Department of Child Neurology, Karadeniz Technical University, Trabzon, Turkey.

Objective: To investigate the potential toxic effects of levetiracetam monotherapy on ocular tissues in cases of pediatric epilepsy using optical coherence tomography (OCT).

Methods: Thirty epileptic children (group 1) receiving levetiracetam monotherapy at a dosage of 20-40 mg/kg/day for at least 1 year with a first diagnosis of epilepsy and 30 age- and gender-matched healthy children (group 2) were included in the study. In addition to a detailed eye examination, peripapillary retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal thickness (FT), and central corneal thickness (CCT) were measured in all children by means of spectral domain OCT. Read More

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http://dx.doi.org/10.1007/s00381-019-04076-5DOI Listing
February 2019

[Astigmatism].

Ophthalmologe 2019 Feb 19. Epub 2019 Feb 19.

Univ.-Augenklinik Düsseldorf, Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Astigmatism is the most frequent refractive error worldwide followed by hyperopia and myopia. Internal astigmatism has to be differentiated from external astigmatism. Furthermore, external astigmatism can be divided into "with the rule", "against the rule" and "oblique". Read More

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http://dx.doi.org/10.1007/s00347-019-0865-7DOI Listing
February 2019

Theta burst stimulation in neglect after stroke: functional outcome and response variability origins.

Brain 2019 Feb 19. Epub 2019 Feb 19.

Gerontechnology and Rehabilitation Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.

Spatial neglect is a strong and negative predictor of general functional outcome after stroke, and its therapy remains a challenge. Whereas inhibitory non-invasive brain stimulation over the contralesional, intact hemisphere has generally been shown to ameliorate neglect on a group level, a conspicuous variability of the effects at the individual level is typically observed. We aimed to assess the characteristics and determinants of the effects of inhibitory non-invasive brain stimulation in neglect, identifying which patients would respond to this therapeutic approach and which not. Read More

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http://dx.doi.org/10.1093/brain/awz029DOI Listing
February 2019

Interocular Symmetry of Fixation, Optic Disc, and Corneal Astigmatism in Bilateral High Myopia: The Shanghai High Myopia Study.

Transl Vis Sci Technol 2019 Jan 13;8(1):22. Epub 2019 Feb 13.

Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People's Republic of China.

Purpose: We investigate the interocular symmetry of fixation, optic disc, and corneal astigmatism in bilateral high myopia, and evaluate the predictive relationships between them.

Methods: We enrolled 202 cases with bilateral high myopia. Fixation, in terms of the bivariate contour ellipse area (BCEA), was evaluated with the Macular Integrity Assessment microperimetry. Read More

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http://dx.doi.org/10.1167/tvst.8.1.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375117PMC
January 2019

Diagnosing and managing diabetic somatic and autonomic neuropathy.

Ther Adv Endocrinol Metab 2019 4;10:2042018819826890. Epub 2019 Feb 4.

Weill Cornell Medicine-Qatar, Education City, Doha 24144, Qatar.

The diagnosis and management of diabetic neuropathy can be a major challenge. Late diagnosis contributes to significant morbidity in the form of painful diabetic neuropathy, foot ulceration, amputation, and increased mortality. Both hyperglycaemia and cardiovascular risk factors are implicated in the development of somatic and autonomic neuropathy and an improvement in these risk factors can reduce their rate of development and progression. Read More

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http://dx.doi.org/10.1177/2042018819826890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365998PMC
February 2019

Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study.

Exp Ther Med 2019 Mar 24;17(3):1891-1895. Epub 2018 Dec 24.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

The aim of the present study was to investigate the utility of diffusion tensor imaging (DTI) parameters of the central visual pathway and the size of the lateral geniculate nucleus (LGN) in the diagnosis of primary open-angle glaucoma (POAG). To test this, 24 POAG patients and 24 age- and gender-matched controls underwent 3.0 Tesla magnetic resonance imaging examinations, including DTI and LGN structural imaging. Read More

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http://dx.doi.org/10.3892/etm.2018.7134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364226PMC

Cochrane Eyes and Vision: a perspective introducing Cochrane Corner in Eye.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Moorfields Eye Hospital NHS Foundation Trust, City Road, London, EC1V 2PD, UK.

In 1972, Archie Cochrane wrote "It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomised controlled trials". The Cochrane Collaboration arose in response to Archie Cochrane's challenge. Cochrane Eyes and Vision aims to prepare and promote access to systematic reviews of interventions for preventing or treating eye conditions and/or visual impairment, and helping people adjust to visual impairment or blindness. Read More

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http://dx.doi.org/10.1038/s41433-019-0357-7DOI Listing
February 2019

Cochrane eyes and vision.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Queen's University, Belfast, UK.

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http://dx.doi.org/10.1038/s41433-019-0341-2DOI Listing
February 2019

Oral fluoxetine in the management of amblyopic patients aged between 10 and 40 years old: a randomized clinical trial.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Poostchi Ophthalmology Research Center, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: The objective of this study is to assess the efficacy of oral fluoxetine therapy in improving the visual function of amblyopic patients aged between 10 and 40 years old.

Methods: In this double-blinded, randomized, controlled trial (IRCT2016052428046N1; registered retrospectively), 40 eligible participants with anisometropic or mixed amblyopia were randomly assigned to either fluoxetine or placebo groups. Participants with anisometropia and logMAR best spectacle-corrected visual acuity (BSCVA) worse than 0. Read More

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http://dx.doi.org/10.1038/s41433-019-0360-zDOI Listing
February 2019

Differing presenting features of idiopathic intracranial hypertension in the UK and US.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Aim: Demographic factors potentially influencing the presentation and severity of idiopathic intracranial hypertension (IIH) in the US vs. UK populations include obesity and ethnicity. We aimed to compare the presenting features of IIH between populations in the UK and US tertiary referral centres, to assess what population differences exist and whether these cause different presentations and impact on visual function. Read More

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http://dx.doi.org/10.1038/s41433-019-0359-5DOI Listing
February 2019

The effect of reduced contrast sensitivity on colour vision testing.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To assess the effect of reduced contrast sensitivity on three commonly used colour vision tests in order to establish key discrepancies that may be relevant for clinical practice.

Methods: A prospective non-interventional clinical study of colour vision testing using three commonly used devices: Ishihara and Hardy-Rand-Rittler (H-R-R) pseudoisocochromatic plate tests, and Farnsworth D-15 arrangement test performed under progressively reduced contrast sensitivity conditions achieved with a neutral density filter bar.

Results: The Pelli-Robson contrast sensitivity (PRCS) at which 5% of the population should first experience a 10% reduction in colour vision testing from baseline was calculated for each of the three colour vision devices: Farnsworth D-15 test: 1. Read More

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http://dx.doi.org/10.1038/s41433-019-0361-yDOI Listing
February 2019

Transcanalicular endoscopic primary dacryoplasty for congenital nasolacrimal duct obstruction.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology and Micro-technology, Yokohama City University Medical Center, Yokohama City, Japan.

Objectives: To examine the causes of congenital nasolacrimal duct obstruction (CNLDO) using dacryoendoscopy, and to evaluate the surgical outcomes of primary transcanalicular endoscopic dacryoplasty.

Methods: The subjects of this study were a total of 56 eyes of 46 Japanese children aged one to five years old (mean, 29.1 ± 14. Read More

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http://dx.doi.org/10.1038/s41433-019-0374-6DOI Listing
February 2019

Management of the photic sneeze reflex utilising the philtral pressure technique.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

University of New South Wales, Kensington, Sydney, Australia.

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http://dx.doi.org/10.1038/s41433-019-0368-4DOI Listing
February 2019

Virtual cleaning and unwrapping of non-invasively digitized soiled bamboo scrolls.

Sci Rep 2019 Feb 19;9(1):2311. Epub 2019 Feb 19.

Pattern Recognition Lab, Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, 91058, Germany.

In ancient China, symbols and drawings captured on bamboo and wooden slips were used as main communication media. Those documents are very precious for cultural heritage and research, but due to aging processes, the discovered pieces are sometimes in a poor condition and contaminated by soil. Manual cleaning of excavated slips is a demanding and time-consuming task in which writings can be accidentally deleted. Read More

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http://dx.doi.org/10.1038/s41598-019-39447-0DOI Listing
February 2019

Anoctamin-4 is a bona fide Ca-dependent non-selective cation channel.

Sci Rep 2019 Feb 19;9(1):2257. Epub 2019 Feb 19.

Experimental Ophthalmology, Department of Ophthalmology, Charité - Universitätsmedizin Berlin, a corporate member of Freie Universität, Humboldt-University, the Berlin Institute of Health, Berlin, Germany.

Changes in cell function occur by specific patterns of intracellular Ca, activating Ca-sensitive proteins. The anoctamin (TMEM16) protein family has Ca-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so far unknown Ano4 function as Ca-dependent, non-selective monovalent cation channel; heterologous Ano4 expression in HEK293 cells elicits Ca activated conductance with weak selectivity of K > Na > Li. Read More

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http://dx.doi.org/10.1038/s41598-018-37287-yDOI Listing
February 2019

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Sci Rep 2019 Feb 19;9(1):2314. Epub 2019 Feb 19.

Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Irreversible photoreceptor cell death is a major cause of blindness in many retinal dystrophies. A better understanding of the molecular mechanisms underlying the progressive loss of photoreceptor cells remains therefore crucial. Abnormal expression of microRNAs (miRNAs) has been linked with the aetiology of a number of retinal dystrophies. Read More

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http://dx.doi.org/10.1038/s41598-018-38294-9DOI Listing
February 2019

Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters.

Ophthalmic Res 2019 Feb 15:1-10. Epub 2019 Feb 15.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou,

Purpose: To measure lamina cribrosa thickness (LCT) and anterior lamina cribrosa surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic primary angle-closure glaucoma (CPACG), and control patients using spectral-domain optical coherence tomography (SD-OCT) and examine its association with relevant ocular parameters.

Methods: In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG patients (65 eyes), and 55 CPACG patients (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way of enhanced depth imaging using Heidelberg SD-OCT. The obtained LCT and ALCSD were compared among the control, POAG, and CPACG groups. Read More

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http://dx.doi.org/10.1159/000496558DOI Listing
February 2019

Prevalence of amblyopia and strabismus in Hani school children in rural southwest China: a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e025441. Epub 2019 Feb 19.

Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Purpose: To determine the prevalence rate of amblyopia and strabismus in Chinese Hani ethnic school-aged children.

Methods: All grade 1 and grade 7 students in Mojiang Hani Autonomous County, located in southwest China, were invited for comprehensive eye examinations performed by experienced ophthalmologists and optometrists, including visual acuity, ocular alignment and movements, cycloplegic autorefraction, anterior segment and fundus examinations. Standard definitions of amblyopia and strabismus were applied to calculate their prevalence rate. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025441DOI Listing
February 2019

Dietary intervention in patients with age-related macular degeneration: protocol for a randomised controlled trial.

BMJ Open 2019 Feb 19;9(2):e024774. Epub 2019 Feb 19.

Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.

Introduction: Age-related macular degeneration (AMD) is a leading cause of blindness. After smoking, nutrition is the key modifiable factor in reducing AMD incidence and progression, and no other preventative treatments are currently available. At present, there is an evidence-practice gap of dietary recommendations made by eye care practitioners and those actually practised by patients with AMD. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024774DOI Listing
February 2019

Identification of barriers, facilitators and system-based implementation strategies to increase teleophthalmology use for diabetic eye screening in a rural US primary care clinic: a qualitative study.

BMJ Open 2019 Feb 18;9(2):e022594. Epub 2019 Feb 18.

Health Innovation Program, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

Objective: Teleophthalmology for diabetic eye screening is an evidence-based intervention substantially underused in US multipayer primary care clinics, even when equipment and trained personnel are readily available. We sought to identify patient and primary care provider (PCP) barriers, facilitators, as well as strategies to increase teleophthalmology use.

Design: We conducted standardised open-ended, individual interviews and analysed the transcripts using both inductive and directed content analysis to identify barriers and facilitators to teleophthalmology use. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022594DOI Listing
February 2019

Depressive symptoms in people with vision impairment: a cross-sectional study to identify who is most at risk.

BMJ Open 2019 Jan 17;9(1):e026163. Epub 2019 Jan 17.

School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK.

Objective: To identify the risk factors for significant depressive symptoms in people with visual impairment in England and Wales to provide information on who is most at risk and to whom support services could be targeted in future.

Design: A cross-sectional study using baseline data from a pragmatic randomised controlled trial.

Setting And Participants: 990 participants aged 18 or over attending 1 of 14 low-vision rehabilitation primary care optometry-based clinics in South Wales or two hospital clinics in London. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026163DOI Listing
January 2019

Neuropsychological correlates of obstructive sleep apnea severity in patients with epilepsy.

Epileptic Disord 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

Obstructive sleep apnea affects up to 30% of patients with epilepsy. As obstructive sleep apnea represents a clinical risk factor for cognitive deficits, its occurrence in epilepsy patients may exacerbate cognitive deficits associated with this condition. However, the cognitive burden of obstructive sleep apnea in epilepsy remains poorly understood. Read More

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http://dx.doi.org/10.1684/epd.2019.1029DOI Listing
February 2019
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