670,635 results match your criteria Optic Plus [Journal]


Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
1 Read

[Pupil disorders].

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

The evaluation of pupillary function is a keystone in the neuro-ophthalmic assessment of patients. The diagnosis of an afferent or efferent pupillary disorder is crucial in the acquisition of a broad range of diseases of the brain or the peripheral nervous system. This "update" of pupillary disorders covers a major part of clinical conditions eye doctors have to expect in their daily practice. Read More

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http://dx.doi.org/10.1055/a-0885-2467DOI Listing

Normal Visual Recovery after Optic Neuritis Despite Significant Loss of Retinal Ganglion Cells in Patients with Multiple Sclerosis.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):425-428. Epub 2019 Apr 18.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland.

Background: Optic neuritis (ON) is a frequent manifestation of demyelinating attack in multiple sclerosis (MS). Initial visual loss can vary from minimal to complete. Visual improvement occurs in about 95% of patients, some of them recovering to normal [visual acuity (VA), color vision, visual field (VF)]. Read More

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http://dx.doi.org/10.1055/a-0853-1721DOI Listing

Vasculitis and Retrofoveal Choroidal Neovessels in a Case of Multifocal Pattern Dystrophy.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):523-525. Epub 2019 Apr 18.

Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Ocular Immuno-infectiology, Lausanne, Switzerland.

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http://dx.doi.org/10.1055/a-0831-2195DOI Listing

Yasunari Nodules: A New Sensitive and Specific Marker of Neurofibromatosis Type 1, Readily Detectable by Ophthalmologists.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):480-482. Epub 2019 Apr 18.

Jules Gonin Eye Hospital, University of Lausanne, Neuro-Ophthalmology Unit, Lausanne, Switzerland.

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http://dx.doi.org/10.1055/a-0829-6725DOI Listing

Optic Neuritis as First Manifestation of Bing-Neel Syndrome.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):472-474. Epub 2019 Apr 18.

Ophtalmology, Ospedale Regionale di Lugano Civico e Italiano, Lugano, Switzerland.

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http://dx.doi.org/10.1055/a-0795-3164DOI Listing

Distant Subconjunctival Recurrences following Proton Therapy for a Choroidal Melanoma with Extrascleral Extension.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):422-424. Epub 2019 Apr 18.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, FAA, Switzerland.

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http://dx.doi.org/10.1055/a-0796-6299DOI Listing

Use of Autologous Oral Mucosa Transplant to Treat Conjunctival Necrosis and Leakage after Trabeculectomy.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):415-416. Epub 2019 Apr 18.

Department of Ophthalmology, Universitatsspital Basel Augenklinik, Basel, Switzerland.

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http://dx.doi.org/10.1055/a-0796-6268DOI Listing

Choroidal Neovascularisation Complicating Chronic Central Serous Chorioretinopathy: The Discovery Rate on Multimodal Imaging.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):536-541. Epub 2019 Apr 18.

Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.

Purpose: To identify the image modality allowing identification of choroidal neovascularisation (CNV) complicating chronic central serous chorioretinopathy (CSCR), including fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography angiography (OCT-A).

Methods: Patients diagnosed with chronic CSCR and secondary CNV were included in the study. The image modalities FA, ICGA, and OCT-A were reviewed for specific CNV signs permitting diagnosis. Read More

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http://dx.doi.org/10.1055/a-0834-6118DOI Listing

The Assessment of Blood Flow Velocities in Retinal Collaterals in Diabetic Retinopathy.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):530-535. Epub 2019 Apr 18.

Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.

Purpose: Diabetic retinopathy (DR) is a microvascular disease characterized by capillary dropout and resultant retinal ischemia which then leads to retinal vascular remodeling. Our goal was to assess blood flow velocities in retinal collateral vessels in healthy and diabetic subjects with various stages of DR.

Methods: In our pilot study, we enrolled five eyes of five healthy subjects (H), five eyes of four subjects with diabetes and no retinopathy (DM), three eyes of three subjects with mild non-proliferative diabetic retinopathy (MDR), and five eyes of four subjects with proliferative diabetic retinopathy (PDR). Read More

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http://dx.doi.org/10.1055/a-0861-9675DOI Listing

Repeat Surgery for Patients Operated in Childhood for Early-Onset Esotropia and Suffering from Persistent Residual, Recurrent or Consecutive Strabismus.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):446-450. Epub 2019 Apr 18.

Pediatric Ophthalmology, Vision Rive Droite, Le Grand Saconnex, Switzerland.

Background: Patients operated in childhood for early esotropia may suffer from persistent strabismus, whether residual, recurrent, or consecutive, usually with a more complex oculomotor imbalance than in primitive strabismus.

History And Signs: The clinical data are fundamental, in particular, (1) the basic accommodation-free deviation, (2) the horizontal far/near incomitance, (3) the cyclovertical incomitances and/or A or V pattern, and (4) the motility restrictions. In complicated cases, magnetic resonance tomography of the orbits showed the anomalies of the eye and muscle position. Read More

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http://dx.doi.org/10.1055/a-0859-6974DOI Listing

Plication versus Resection in Horizontal Strabismus Surgery.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):442-445. Epub 2019 Apr 18.

University Eye Hospital Basel, Basel, Switzerland.

Background: To compare two commonly used strengthening procedures in strabismus surgery: plication and resection of the extraocular muscle (EOM).

Patients And Methods: From an anonymous databank of strabismus surgeries, performed at the University Eye Hospital Basel, patients with a horizontal strabismus surgery, consisting of a recession combined with either plication or resection of the antagonist and a follow-up of at least 3 months, were included. Exclusion criteria were previous eye surgeries, binocular surgeries, and simultaneous surgery of oblique or vertical EOM. Read More

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http://dx.doi.org/10.1055/a-0829-6086DOI Listing

Comparing Three Different Contrast Sensitivity Tests in Adults and in Children with and without Amblyopia.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):434-437. Epub 2019 Apr 18.

University Eye Hospital Basel, Basel, Switzerland.

Background: Tests of contrast sensitivity (CS) are not routinely performed in the clinic, although CS is reduced in many conditions, such as amblyopia or glaucoma. This may be due to perceived time constraints or unaffordability of equipment.

Patients And Methods: Monocular CS functions obtained with the FACT, CSV 1000E, and Lea Symbols were compared in 19 healthy subjects aged 24 - 78 years and 24 subjects aged 5 - 16 years, 9 of whom had amblyopia. Read More

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http://dx.doi.org/10.1055/a-0853-1683DOI Listing

The Use of Junfeng BFS Water (JBW) in Dry Eye Syndrome.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):366-370. Epub 2019 Apr 18.

Augenklinik, Otto von Guericke Universität Magdeburg, Magdeburg, Germany.

Background And Purpose: Junfeng BFS Water (JBW) is normal drinking water treated by an extremely low frequency electromagnetic field with certain electromagnetic oscillations. This leads to a change in physical water properties, such as an increase in permittivity and an increase in dissolved oxygen. Animal studies show that JBW has certain biological effects, such as improvement in microcirculation, cell hydration, and blood rheology. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0838-4836
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http://dx.doi.org/10.1055/a-0838-4836DOI Listing
April 2019
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A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. II. Abnormal Near Response Cell Activity in the Supraoculomotor Area.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1670-1676

Washington National Primate Research Center, University of Washington, Seattle, Washington, United States.

Purpose: Convergence insufficiency is a very common disorder that can have significant adverse effects on school performance. When reading, children with this disorder often experience diplopia and headaches. We have recently obtained a rhesus monkey with a naturally occurring impairment of vergence eye movements. Read More

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http://dx.doi.org/10.1167/iovs.18-26440DOI Listing

A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. I. Behavioral Comparisons to Vergence in a Normal Animal.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1657-1669

Washington National Primate Research Center, University of Washington, Seattle, Washington, United States.

Purpose: Human children with disorders affecting vergence eye movements have difficulty during close work, such as reading. Patients with convergence insufficiency show a receded near point and an exophoria that is greater at near than at far. Neurologic abnormalities may underlie these symptoms, but it is difficult to test this idea directly because there is no animal model for this disorder. Read More

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http://dx.doi.org/10.1167/iovs.18-26438DOI Listing

Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing

Comparative transcriptome analysis of human conjunctiva between normal and conjunctivochalasis persons by RNA sequencing.

Exp Eye Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.

Conjunctivochalasis (CCH) is a common ocular disease, especially in aged people. However, the molecular mechanism of CCH on transcriptional level has been unclear. In this study, we characterized the transcriptional landscape of human conjunctiva and compared the transcriptome between normal persons (n = 10) and CCH patients (n = 11). Read More

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http://dx.doi.org/10.1016/j.exer.2019.04.005DOI Listing

Epigallocatechin-3-gallate stimulates autophagy and reduces apoptosis levels in retinal Müller cells under high-glucose conditions.

Exp Cell Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, 215021, China. Electronic address:

Retinal neurodegeneration is an early feature in the pathogenesis of diabetic retinopathy (DR). Autophagy is an intracellular catabolic process involved in protein and organelle degradation that has been linked in DR. Epigallocatechin gallate (EGCG) is a major polyphenol in green tea that has beneficial effects in diabetic. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.04.014DOI Listing

Functional characterization of CEP250 variant identified in nonsyndromic retinitis pigmentosa.

Hum Mutat 2019 Apr 18. Epub 2019 Apr 18.

Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Retinitis pigmentosa (RP) is the most common manifestation of inherited retinal diseases with high degree of genetic, allelic, and phenotypic heterogeneity. CEP250 encodes the C-Nap1 protein and has been associated with various retinal phenotypes. Here, we report the identification of a mutation (c. Read More

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http://dx.doi.org/10.1002/humu.23759DOI Listing

Utility of Ophthalmic Consultations for Patients With Candidemia.

Authors:
Benjamin J Kim

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0589DOI Listing

Longitudinal Clinical Follow-up and Genetic Spectrum of Patients With Rod-Cone Dystrophy Associated With Mutations in PDE6A and PDE6B.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Sorbonne Université, Institut national de la santé et de la recherche médicale, Centre national de la recherche scientifique, Institut de la Vision, Paris, France.

Importance: A precise phenotypic characterization of retinal dystrophies is needed for disease modeling as a basis for future therapeutic interventions.

Objective: To compare genotype, phenotype, and structural changes in patients with rod-cone dystrophy (RCD) associated with mutations in PDE6A or PDE6B.

Design, Setting, And Participants: In a retrospective cohort study conducted in Paris, France, from January 2007 to September 2017, 54 patients from a cohort of 1095 index patients with RCD underwent clinical examination, including personal and familial history, best-corrected visual acuity (BCVA), color vision, slitlamp examination, full-field electroretinography, kinetic visual fields (VFs), retinophotography, optical coherence tomography, near-infrared fundus autofluorescence, and short-wavelength fundus autofluorescence imaging. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.6367DOI Listing

Utility of Ophthalmologic Screening for Patients With Candida Bloodstream Infections: A Systematic Review.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Vanderbilt University School of Medicine, Nashville, Tennessee.

Importance: The Infectious Diseases Society of America recommends ophthalmologic examinations for everyone with positive Candida blood culture results (candidemia) to screen for endophthalmitis, a practice that remains controversial because of multiple concerns for its limited usefulness and potential for harm.

Objective: To determine guideline efficacy by reconciling discrepancies in the incidence of endophthalmitis and evaluating outcomes of studies assessing ophthalmologic screening for candidemia.

Evidence Review: PubMed literature searches, including the search terms candidemia, fungemia, chorioretinitis, and endophthalmitis, identified longitudinal studies prior to 2018 of patients who underwent ophthalmologic evaluations in the setting of positive fungal blood culture results regardless of symptoms or clinical status. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0733DOI Listing

Association of Exercise and Swimming Goggles With Modulation of Cerebro-ocular Hemodynamics and Pressures in a Model of Spaceflight-Associated Neuro-ocular Syndrome.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Integrated Cardiovascular Exercise Physiology and Rehabilitation Laboratory, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington.

Importance: Astronauts on International Space Station missions demonstrate adverse neuro-ocular changes. Reversing a negative translaminar pressure gradient (TLPG) by modulating cerebral blood flow, decreasing intracranial pressure, or increasing intraocular pressure (IOP) has been proposed as potential intervention for spaceflight-associated neuro-ocular syndrome (SANS).

Objective: To examine whether exercise (resistance, moderate-intensity aerobic, and high-intensity aerobic) or artificially increasing IOP is associated with modulated cerebro-ocular hemodynamic and pressure changes during head-down tilt (HDT), an analogue of spaceflight, in healthy adults. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0459DOI Listing

Appearance of Polypoidal Lesions in Patients With Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomographic Angiography.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Importance: Polypoidal choroidal vasculopathy (PCV) is a major cause of visual loss worldwide, particularly in Asia, and the appropriate understanding of the structures in PCV previously described as polypoidal lesions is important for understanding their pathogenesis, diagnosis, and prognosis.

Objective: To report the morphologic characteristics of polypoidal lesions and their association with branching vascular networks (BVNs) in eyes with PCV using swept-source optical coherence tomographic angiography (SS-OCTA).

Design, Setting, And Participants: This cross-sectional observational study included 20 participants recruited from Shanghai General Hospital with a diagnosis of PCV based on the presence of focal hyperfluorescent spots on indocyanine green angiography (ICGA). Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0449DOI Listing

Insights of Swept-Source Optical Coherence Tomographic Angiography on the Structures in Polypoidal Choroidal Vasculopathy.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Fundus Image Reading Centre, National Healthcare Group Eye Institute, Singapore.

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0412DOI Listing

Modulation of Cerebro-ocular Hemodynamics and Pressures in a Model of SANS Using Swimming Goggles.

Authors:
Andrew G Lee

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Blanton Eye Institute, Houston Methodist Eye Associates, Houston, Texas.

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0414DOI Listing
April 2019
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Therapeutic Window for Phosphodiesterase 6-Related Retinitis Pigmentosa.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology and Pathology and Cell Biology, Columbia Stem Cell Initiative, Institute of Human Nutrition, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.6381DOI Listing

CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice.

PLoS One 2019 18;14(4):e0215727. Epub 2019 Apr 18.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, CA, United States of America.

Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of subsequent pathologic inflammatory responses and therefore, the accumulation of immune cell populations at this time point is a key target for prevention. Therefore, we evaluated the role of various immune cell infiltrates between 1 h and 28 days post-infection (PI) using mice infected with virulent HSV-1 strain McKrae without corneal scarification. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215727PLOS

Population prevalence of myopia, glasses wear and free glasses acceptance among minority versus Han schoolchildren in China.

PLoS One 2019 18;14(4):e0215660. Epub 2019 Apr 18.

Lancang County First People's Hospital, Lancang, Yunnan, China.

Aim: To measure myopia, glasses wear and free glasses acceptance among minority and Han children in China.

Methods: Visual acuity testing and questionnaires assessing ethnicity, study time, and parental and teacher factors were administered to a population-based sample of 9-12 year old minority and Han children in Yunnan and Guangdong, and their teachers and parents. Refraction was performed on children with uncorrected visual acuity (VA) < = 6/12 in either eye, and acceptance of free glasses assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215660PLOS

Where Do We Look? Assessing Gaze Patterns in Cosmetic Facelift Surgery with Eye Tracking Technology.

Plast Reconstr Surg 2019 Apr 9. Epub 2019 Apr 9.

Division of Plastic and Reconstructive Surgery, Stanford University, Palo Alto Stanford School of Medicine, Palo Alto Stanford School of Medicine, Palo Alto Division of Plastic and Reconstructive Surgery, Stanford University, Palo Alto Division of Plastic and Reconstructive Surgery, Stanford University, Palo Alto Division of Plastic and Reconstructive Surgery, Stanford University, Palo Alto.

Purpose: Aesthetics plays a central role in determining success in plastic surgery. Understanding perceptions of favorable aesthetics is critical to ensure patient satisfaction. Eye-tracking technology offers an objective way to evaluate attention and understand how viewers direct their focus in patients who undergo cosmetic facelift procedures. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005700DOI Listing

Corneal Tomography Changes and Refractive Outcomes After Descemet Stripping Without Endothelial Keratoplasty.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

Purpose: To investigate corneal tomography changes and refractive outcomes after Descemetorhexis without endothelial keratoplasty (DWEK).

Methods: Retrospective chart review of 25 eyes from 16 patients with Fuchs corneal endothelial dystrophy that underwent successful DWEK combined with cataract surgery.

Results: There was no significant change in anterior corneal curvature on tomography maps. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001896DOI Listing

Expressible Meibomian Glands Have Occult Fixed Obstructions: Findings From Meibomian Gland Probing to Restore Intraductal Integrity.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Dry Eye and Cornea Treatment Center, Tampa, FL.

Purpose: To describe and quantify findings of intraductal obstruction during probing expressible and nonexpressible meibomian glands (MGs) in patients with obstructive meibomian gland dysfunction using a 1-mm intraductal MG probe.

Methods: A retrospective study of probe findings from 108 consecutive patients. Nonparametric tests using SPSS software 25. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001954DOI Listing

Vestibular Aqueduct Morphology Correlates With Endolymphatic Sac Pathologies in Menière's Disease-A Correlative Histology and Computed Tomography Study.

Otol Neurotol 2019 Apr 12. Epub 2019 Apr 12.

Department of Otolaryngology, Harvard Medical School.

Hypothesis: The vestibular aqueduct (VA) in Menière's disease (MD) exhibits different angular trajectories depending on the presenting endolymphatic sac (ES) pathology, i.e., 1) ES hypoplasia or 2) ES degeneration. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002198DOI Listing

Presentation, Management, and Outcome of Lingual Thyroglossal Duct Cyst in Pediatric and Adult Populations.

J Craniofac Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Oral and Maxillofacial Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.

Lingual thyroglossal duct cysts (LTDCs) are rare congenital anomalies of the neck. The authors described the presentation, management, and outcome of LTDC in pediatric and adult cases through a retrospective observational analysis between 2008 and 2018. Data included patients' demographics, main complaint, preoperative investigations, surgical management, and recurrences. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005522DOI Listing
April 2019
0.676 Impact Factor

Children With Congenital Unilateral Sensorineural Hearing Loss: Effects of Late Hearing Aid Amplification-A Pilot Study.

Ear Hear 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Objectives: Although children with unilateral hearing loss (uHL) have high risk of experiencing academic difficulties, speech-language delays, poor sound localization, and speech recognition in noise, studies on hearing aid (HA) outcomes are few. Consequently, it is unknown when and how amplification is optimally provided. The aim was to study whether children with mild-to-moderate congenital unilateral sensorineural hearing loss (uSNHL) benefit from HAs. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000730DOI Listing

Influence of melanin characteristics on drug binding properties.

Mol Pharm 2019 Apr 18. Epub 2019 Apr 18.

Melanins are biopolymers encompassing a high degree of chemical heterogeneity. Binding of small molecule drugs to ocular melanin significantly affects the ocular pharmacokinetics and it could serve as a strategy for prolonged drug retention in the eye. The influence of the structural and physical characteristics of melanins originating from different sources on their drug binding properties has not yet been methodically investigated. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00157DOI Listing

Intraoperative Optical Coherence Tomography Demonstrating Macular Hole Associated With Ruptured Retinal Arterial Macroaneurysm.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e125-e127

A 67-year-old female presented with vitreous hemorrhage and sub-internal limited membrane (ILM) hemorrhage in her right eye associated with ruptured retinal arterial macroaneurysm. During pars plana vitrectomy, intraoperative optical coherence tomography aided in the diagnosis of a small macular hole previously obscured by the sub-ILM hemorrhage. Nonexpansile gas was placed followed by postoperative prone positioning, and the hole closed successfully. Read More

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http://dx.doi.org/10.3928/23258160-20190401-17DOI Listing

Higher Vascular Density of the Superficial Retinal Capillary Plexus in Degenerative Lamellar Macular Holes.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e112-e117

Background And Objective: Optical coherence tomography angiography (OCTA) comparison between vessel density in patients with degenerative-subtype lamellar macular hole (LMH) and healthy individuals. Unaffected fellow eyes were also included in the study.

Patients And Methods: This observational, cross-sectional study examined 32 eyes affected by unilateral degenerative-subtype LMH, as well as the 32 fellow eyes of the enrolled population. Read More

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http://dx.doi.org/10.3928/23258160-20190401-15DOI Listing

Microcornea, Posterior Megalolenticonus, Persistent Fetal Vasculature, and Coloboma Syndrome Associated With a New Mutation in ZNF408.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):253-256

The authors report a case of a 6-week-old girl with microphthalmia, posterior lenticonus, persistent fetal vasculature, and coloboma of the right eye, with morning glory disc anomaly and falciform retinal folds of the left eye. Genetic testing revealed a previously unreported mutation (c.1471A>G [p. Read More

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http://dx.doi.org/10.3928/23258160-20190401-10DOI Listing

Exudative Retinal Detachment Following Intravitreal Chemotherapeutic Treatment for Retinoblastoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):248-252

A 35-month-old boy was diagnosed with retinoblastoma and underwent combination intra-arterial (IAC) and intravitreal chemotherapy. His course was complicated by anaphylactic reaction to IAC, yet he continued to improve with sustained intravitreal therapy. Eight months into treatment, the affected eye developed exudative retinal detachment, which resolved with sub-Tenon's steroid administration. Read More

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http://dx.doi.org/10.3928/23258160-20190401-09DOI Listing

Spontaneous Hyaloidal Contraction and Complex Retinal Detachment in a Patient With Von Hippel-Lindau Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):238-241

The authors present an interventional case report of a patient with von Hippel-Lindau (VHL) syndrome who developed simultaneous exudative and combined tractional, rhegmatogenous, and exudative retinal detachment (RD) in the right and left eyes, respectively, following uneventful cryotherapy application of retinal capillary hemangioblastoma (RCH). After pars plana vitrectomy combined with encircling scleral buckling with radial element placement and silicone oil injection, complete retinal reattachment was achieved. The exudative RD of the fellow eye was managed initially with intense topical corticosteroid treatment and subsequent placement of a radial scleral buckle due to the presence of clinically apparent traction. Read More

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http://dx.doi.org/10.3928/23258160-20190401-07DOI Listing

Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):221-227

Background And Objective: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time.

Patients And Methods: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats' disease.

Results: Three hundred fifty eyes of 175 patients with Coats' disease were analyzed. Read More

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http://dx.doi.org/10.3928/23258160-20190401-04DOI Listing

Analog Derivatization of Cannabidiol for Improved Ocular Permeation.

J Ocul Pharmacol Ther 2019 Apr 18. Epub 2019 Apr 18.

1 Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, Mississippi.

Cannabidiol (CBD), active component of plant , has anti-inflammatory properties that could potentially help treat diabetic retinopathy-induced pain and inflammation. However, CBD is a lipophilic molecule making its topical delivery to back of the eye challenging. This study aims at improving ocular penetration of CBD by means of analog derivatization. Read More

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http://dx.doi.org/10.1089/jop.2018.0141DOI Listing

An outreach program with hands-on, physiology-based exercises generates questions about STEM career expectations.

Adv Physiol Educ 2019 Jun;43(2):175-179

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center , Omaha, Nebraska.

Scientific advocacy and outreach programs are encouraged to increase public understanding of scientific knowledge and generate interest in science, technology, engineering, and mathematics (STEM) careers. However, evaluation of these events' effectiveness is difficult and somewhat rare. This study's purpose was to better understand how effective an established physiology-based outreach program was in generating interest in STEM careers, while simultaneously providing information that can be used to increase the effectiveness of future events. Read More

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http://dx.doi.org/10.1152/advan.00013.2019DOI Listing

A valence asymmetry in predecisional distortion of information: Evidence from an eye tracking study with incentivized choices.

J Exp Psychol Learn Mem Cogn 2019 Apr 18. Epub 2019 Apr 18.

Wrocław Faculty of Psychology.

Existing research shows that the order in which evidence arrives can bias its evaluation and the resulting decision in favor of information encountered early on. We used eye-tracking to study the underlying cognitive mechanisms in the context of incentivized financial choices based on real world market data. Subjects learned about the presence/absence of a transaction fee, before seeing expert opinions regarding an investment prospect and deciding whether to invest. Read More

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http://dx.doi.org/10.1037/xlm0000711DOI Listing

[Extended optic neuropathy with myelin oligodendrocyte glycoprotein antibodies].

Rev Med Liege 2019 Apr;74(4):179-184

Service de Neurologie, CHU Liège, Belgique.

The discovery of autoantibodies targeting aquaporin-4 (AQP4) of astrocytes has improved the understanding and management of Neuromyelitis Optica Syndrome Disorders (NMO-SD), previously considered as a variant of multiple sclerosis. Later, the detection of MOG IgG1 antibodies, directed against an oligodendrocyte myelin glycoprotein, made it possible to distinguish pathologies with different clinical and prognostic particularities, then helping the clinician in his diagnostic and therapeutic approach. This clinical case aims to feature the clinical differences, prognosis and therapeutic solutions of these pathologies. Read More

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Surface-Independent and Oriented Immobilization of Antibody via One-Step Polydopamine/Protein G Coating: Application to Influenza Virus Immunoassay.

Macromol Biosci 2019 Apr 18:e1800486. Epub 2019 Apr 18.

Bionanotechnology Research Center, KRIBB, Daejeon, 34141, Korea.

For the construction of high-performance biosensor, it is important to interface bioreceptors with the sensor surface densely and in the optimal orientation. Herein, a simple surface modification method that can optimally immobilize antibodies onto various kinds of surfaces is reported. For the surface modification, a mixture of polydopamine (PDA) and protein G was employed. Read More

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http://dx.doi.org/10.1002/mabi.201800486DOI Listing

Vision loss with pembrolizumab treatment: A report of two cases.

J Oncol Pharm Pract 2019 Apr 18:1078155219841683. Epub 2019 Apr 18.

University of Kansas Medical Center, Kansas City, KS.

Background: Vision loss and other ocular toxicities are rare, but detrimental, side effects of immune checkpoint inhibitors. Herein, we report two patients who developed vision loss while on pembrolizumab treatment.

Cases Presentation: Case 1 - A 58-year-old man was started on pembrolizumab for advanced melanoma. Read More

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http://dx.doi.org/10.1177/1078155219841683DOI Listing
April 2019
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Effects of sex, eye-side, diurnal variation on intraocular pressure in calves.

Pol J Vet Sci 2019 Mar;22(1):67-74

Vocational School of Health Services, Firat University, Elazig, Turkey.

The aim of this study was to determine the effects of factors such as sex, eye-side and diurnal variation on intraocular pressure (IOP) values measured by Tono-Pen Vet® in healthy calves. Twenty four (12 males, 12 females) calves were used in this study. IOP measurements were per- formed in the morning (6:00 a. Read More

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http://dx.doi.org/10.24425/pjvs.2018.125609DOI Listing
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