661,264 results match your criteria Optic Plus [Journal]


Gaze allocation in face-to-face communication is affected primarily by task structure and social context, not stimulus-driven factors.

Cognition 2018 Dec 14;184:28-43. Epub 2018 Dec 14.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; Developmental Psychology, Utrecht University, Utrecht, the Netherlands; Brain Center Rudolf Magnus, University Medical Center, Utrecht, the Netherlands.

Gaze allocation to human faces has recently been shown to be greatly dependent on the social context. However, what has not been considered explicitly here, is how gaze allocation may be supportive of the specific task that individuals carry out. In the present study, we combined these two insights. Read More

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December 2018

Identifying sublethal endpoints for evaluating neurotoxic compounds utilizing the fish embryo toxicity test.

Ecotoxicol Environ Saf 2018 Dec 14;170:521-529. Epub 2018 Dec 14.

Department of Biology, Texas Christian University, Fort Worth, TX, USA. Electronic address:

Fish embryos are increasingly being utilized in aquatic toxicity testing, as evidenced by the Organisation for Economic Co-operation and Development's approval of the fish embryo acute toxicity (FET) test. However, the FET test only allows for the estimation of acute toxicity, whereas other test methods such as the larval growth and survival (LGS) test allow for the estimation of both acute and chronic toxicity. Additionally, it has been demonstrated that the FET test is less sensitive than other test methods for some neurotoxic compounds. Read More

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December 2018
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Identification of the proteoforms of surface localized Rod A of Aspergillus flavus and determination of the mechanism of proteoform generation.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Department of Proteomics, Aravind Medical Research Foundation, Aravind Eye Care System, Dr. G. Venkataswamy Eye Research Institute, No:1 Anna Nagar, Madurai, TN, India. Electronic address:

Fungal keratitis is a serious, potentially sight-threatening corneal infection that is more prevalent in the tropical parts of the world including India, and A. flavus and Fusarium solani are the predominant etiological agents. The surface of fungal conidia is covered by hydrophobin family proteins, effectively masking the conidial antigens from immune cells. Read More

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December 2018

The effect of dietary carotenoid increase on painted turtle spot and stripe color.

Comp Biochem Physiol B Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, PO Box 5000, Shepherd University, Shepherdstown, WV. USA. 25443.

Determination of how carotenoid-based color patches change with pigmentary access is important to understanding color patch function in animals. We performed a carotenoid addition experiment on male painted turtles (Chrysemys picta) to determine if an increase in dietary carotenoids led to location-specific changes in painted turtle spot and stripe color. Turtles fed large quantities of carotenoids had increased yellow chroma in chin stripes and increased red chroma in the neck and carapace stripes, as well as reduced ultraviolet (UV) chroma in the neck (orange to the human eye) and fore -limb (red to the human eye) stripes. Read More

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December 2018
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Corneal regeneration by conditioned medium of human uterine cervical stem cells is mediated by TIMP-1 and TIMP-2.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Faculty of Science, University of A Coruña, Spain. Electronic address:

The aim off the present study was to evaluate the effect and the mechanism of action of the conditioned medium from human uterine cervical stem cells (CM-hUCESC) on corneal wound healing in a rabbit dry eye model. To do this, dry eye and corneal epithelial injuries were induced in rabbits by topical administration of atropine sulfate and NaOH. Hematoxylin-Eosin (H&E) and Ki-67 immunostaining were carried out to evaluate corneal damage and cell proliferation, and real-time PCR was used to evaluate proinflammatory cytokines in the cornea. Read More

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December 2018

R125H, W240S, C386R, and V507I SLC4A11 mutations associated with corneal endothelial dystrophy affect the transporter function but not trafficking in PS120 cells.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

School of Optometry, Indiana University Bloomington, Bloomington, IN, USA. Electronic address:

SLC4A11 mutations are associated with Fuchs' endothelial corneal dystrophy (FECD), congenital hereditary endothelial dystrophy (CHED) and Harboyan syndrome (endothelial dystrophy with auditory deficiency). Mice with genetically ablated Slc4a11 recapitulate CHED, exhibiting significant corneal edema and altered endothelial morphology. We recently demonstrated that SLC4A11 functions as an NH sensitive, electrogenic H transporter. Read More

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December 2018
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Optic nerve head width and retinal nerve fiber layer changes are good indexes for validating the successful induction of experimental anterior ischemic optic neuropathy.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Eye Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Reproducible skills are essential for successful induction of a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by measuring the natural course of optic nerve head (ONH) width and retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. Read More

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December 2018

Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface.

Am J Ophthalmol 2018 Dec 14. Epub 2018 Dec 14.

Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.

Purpose: To correlate spectral-domain optical coherence tomography (SD-OCT) criteria and clinical data with pathology of the vitreomacular interface (VMI) in eyes with diabetic macular edema (DME).

Design: Retrospective cross-sectional study and laboratory investigation.

Methods: We included specimens of 27 eyes of 26 patients with center-involved DME that underwent vitrectomy with peeling of the internal limiting membrane (ILM). Read More

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December 2018

Screening for Hydroxychloroquine Retinopathy-Can We Do Better?

Retina 2018 Dec 14. Epub 2018 Dec 14.

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

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December 2018

CUTICULAR DRUSEN: Risk of Geographic Atrophy and Macular Neovascularization.

Retina 2018 Dec 14. Epub 2018 Dec 14.

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.

Purpose: Cuticular drusen (CD) have been associated with manifestations of age-related macular degeneration such as atrophy and neovascularization in the macula. In this study, eyes with CD were followed and investigated for the estimated 5-year risk of progression to sequelae of age-related macular degeneration such as geographic atrophy (GA) and macular neovascularization (MNV).

Methods: A consecutive series of patients with CD were followed for the development of GA and MNV. Read More

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December 2018
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Wavefront-Guided Photorefractive Keratectomy in the Treatment of High Astigmatism Following Keratoplasty.

Cornea 2018 Dec 14. Epub 2018 Dec 14.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To report the outcome of wavefront-guided photorefractive keratectomy (WG-PRK) in the treatment of high astigmatism following keratoplasty.

Methods: A retrospective, interventional analysis including patients with high astigmatism following either penetrating keratoplasty or deep anterior lamellar keratoplasty, who underwent WG-PRK.

Results: Thirteen eyes (7 right eyes) of 12 patients (10 male) aged 35. Read More

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December 2018

Embryogenesis and early larval development in wild-caught Levantine scraper, Capoeta damascina (Valenciennes, 1842).

J Morphol 2019 Jan;280(1):133-148

School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL, USA.

Levantine scraper, Capoeta damascina is a candidate species for future stock assessments, conservation studies, and hatchery efforts. Herein, we documented embryonic and early larval development, from egg activation to the exogenous feeding period, using morphological and histological landmarks. Embryos were obtained by in vitro fertilization from hormonally induced wild-caught broodstock, and subsequent development was monitored at temperatures coinciding with native conditions. Read More

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January 2019

Selective S Cone Damage and Retinal Remodeling Following Intense Ultrashort Pulse Laser Exposures in the Near-Infrared.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5973-5984

Center for Visual Science, University of Rochester, Rochester, New York, United States.

Purpose: Infrared ultrashort pulse lasers are becoming increasingly popular for applications in the living eye. However, safety standards are not yet well established. Here we investigate retinal damage close to threshold for this pulse regime in the living macaque eye. Read More

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December 2018

Diagnostic Errors in Initial Misdiagnosis of Optic Nerve Sheath Meningiomas.

JAMA Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

Importance: Diagnostic errors can lead to the initial misdiagnosis of optic nerve sheath meningiomas (ONSM), which can lead to vision loss.

Objective: To identify factors contributing to the initial misdiagnosis of ONSM.

Design, Setting, And Participants: We retrospectively reviewed 35 of 39 patients with unilateral ONSM (89. Read More

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December 2018
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Modified No-Touch Technique for Removal of a Dexamethasone Implant that has Migrated to the Anterior Chamber.

Authors:
Jay M Stewart

Ocul Immunol Inflamm 2018 Dec 17:1-2. Epub 2018 Dec 17.

a Department of Ophthalmology , University of California , San Francisco , California , USA.

The dexamethasone intravitreal implant poses a risk to the cornea if it migrates into the anterior chamber. Because it tends to fracture if grasped with surgical instruments, no-touch techniques represent the most successful means of removing the device from the eye. The present report describes a new approach in which the implant is aspirated into the lumen of a needle, providing the surgeon with greater control in accessing the device within the anterior chamber. Read More

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December 2018

Ocular Involvement in Muckle-Wells Syndrome.

Ocul Immunol Inflamm 2018 Dec 17:1-9. Epub 2018 Dec 17.

a Pediatric Allergy and Clinical Immunology , Uludag University School of Medicine , Bursa , Turkey.

Purpose: To present the ocular findings of the members of a family that has the diagnosis of Muckle Wells syndrome, a form of cryopyrin associated periodic syndrome (CAPS).

Materials And Methods: Nine patients with MWS were included in this study. Each study participant underwent a systemic evaluation, comprehensive ophthalmic examination, and auxillary testings. Read More

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December 2018
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Comparison of Spectral Domain Optical Coherence Tomography (SD OCT) Findings with Laser Flare Photometry (LFP) Measurements in Behçet's Uveitis.

Ocul Immunol Inflamm 2018 Dec 17:1-6. Epub 2018 Dec 17.

b Ophthalmology, Faculty of Medicine , Ankara University , Ankara , Turkey.

Purpose: This study aims to compare the spectral domain optical coherence tomography (SD OCT) findings and laser flare photometry (LFP) measurements in Behçet's disease (BD).

Methods: This study was composed of 4 groups as follows: "Group 1: Healthy volunteers, Group 2: Volunteers with BD and no eye involvement, Group 3: Patients with active uveitis with BD, Group 4: Patients with BD in quiescent phase of uveitis". Laser Flare Photometry (Kowa FM-600, Kowa Acculas, San Jose, CA, USA), SD-OCT and Enhanced Depth Imaging protocol (EDI) (Spectralis®, Heidelberg Engineering Inc. Read More

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December 2018

Familial Nanophthalmos Presenting with Spontaneous Uveal Effusion Syndrome.

Ocul Immunol Inflamm 2018 Dec 17:1-3. Epub 2018 Dec 17.

a Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: To report two unique cases of spontaneous uveal effusion syndrome (UES) from the same family.

Methods: The patients included father (54 years old) and a daughter (23 years old). The father presented 7 years ago with bilateral exudative retinal detachment, nanophthalmic eyes (axial length 16. Read More

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December 2018

I see what you meant to say: Anticipating speech errors during online sentence processing.

J Exp Psychol Gen 2018 Dec 17. Epub 2018 Dec 17.

Department of Psychology, University of California, Davis.

Everyday speech is rife with errors and disfluencies, yet processing what we hear usually feels effortless. How does the language comprehension system accomplish such an impressive feat? The current experiment tests the hypothesis that listeners draw on relevant contextual and linguistic cues to anticipate speech errors and mentally correct them, even before receiving an explicit correction from the speaker. In the current visual-world eye-tracking experiment, we monitored participants' eye movements to objects in a display while they listened to utterances containing reparandum-repair speech errors (e. Read More

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December 2018

Evaluation of the current status of the eye lens radiation exposure in an Interventional Radiology department.

Med Lav 2018 Dec 20;109(6):471-477. Epub 2018 Dec 20.

Dipartimento di Fisica, Università degli Studi di Napoli Federico II.

Background: Following recent epidemiological studies, which showed tissue reactions from ionizing radiation at significantly lower doses, the 2013/59 EURATOM Directive of 5th December 2013 lowered the limit on the equivalent dose to the eye lens from 150 mSv to 20 mSv per year. Therefore, as a precautionary measure, it is considered appropriate to perform a timely dose monitoring by using specific dosimeters.

Objectives: Analysis of the current state of the eye lens exposures during interventional procedures. Read More

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December 2018

Lead Intoxication in Free-Ranging Bald Eagles ( Haliaeetus leucocephalus).

Vet Pathol 2018 Dec 16:300985818813099. Epub 2018 Dec 16.

2 The Raptor Center, University of Minnesota, St. Paul, MN, USA.

Lead toxicity due to ingestion of spent ammunition is an ongoing cause of mortality in bald eagles. While gross and histologic lesions of lead intoxication have been described in a few individuals of this species, the prevalence of lesions is underreported. A retrospective study of 93 bald eagles with severe lead intoxication was performed to describe the associated lesions and their prevalence and to compare the lesions with blood, liver, kidney, and/or bone lead concentrations. Read More

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December 2018

Intravitreal fluocinolone acetonide implant (ILUVIEN®) for diabetic macular oedema: a literature review.

J Int Med Res 2018 Dec 16:300060518816884. Epub 2018 Dec 16.

2 Eye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.

Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy and may lead to severe visual loss. In this review, we describe the pathophysiology of DMO and review current therapeutic options such as macular laser photocoagulation, anti-vascular endothelial growth factor agents, and steroid implants with a focus on the new fluocinolone acetonide implant, ILUVIEN®. The results of the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) studies are also presented together with the results of real-world studies to support the clinical use of ILUVIEN® in achieving efficient resolution of DMO and improving vision and macular anatomy in this challenging group of patients. Read More

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December 2018

Clinical Features and Endolymphatic Hydrops in Patients With MRI Evidence of Hydrops.

Ann Otol Rhinol Laryngol 2018 Dec 17:3489418819551. Epub 2018 Dec 17.

1 ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.

Objectives:: The purpose of this study was to investigate the correlation between grades of endolymphatic hydrops (ELH) and clinical characteristics and determine the detailed clinical characteristics of Ménière's disease (MD) patients with evidence of hydrops based on magnetic resonance imaging (MRI).

Methods:: One hundred ninety-eight MD patients (396 ears) with MRI evidence of hydrops were included. ELH grades were evaluated using the Nakashima grading standard. Read More

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December 2018

Can Artificial Intelligence Make Screening Faster, More Accurate, and More Accessible?

Asia Pac J Ophthalmol (Phila) 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Diabetic retinopathy, glaucoma, and age-related macular degeneration are leading causes of vision loss and blindness worldwide. They tend to be asymptomatic in the early phase of disease and therefore require active screening programs to identify the patients requiring referral and treatment. Deep learning-based artificial intelligence technology has recently become a major topic in the field of ophthalmology. Read More

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December 2018

An 11-gene-based prognostic signature for uveal melanoma metastasis based on gene expression and DNA methylation profile.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Uveal melanoma (UM) is the most common intraocular tumor worldwide. We proposed to identify a vital gene signature that has prognostic value for UM metastasis. For this purpose, we obtained a published DNA methylation and gene expression data set associated with UM from the Gene Expression Omnibus. Read More

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December 2018

Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and Systemic Serious Adverse Events.

Ophthalmol Retina 2018 Feb;2(2):118-127

Centre for Experimental Medicine, Queen's University, Belfast, United Kingdom.

Purpose: To describe serum vascular endothelial growth factor (sVEGF) in patients with neovascular age-related macular degeneration (nAMD) receiving anti-VEGF agents and associations between sVEGF and systemic serious adverse events (SSAEs).

Design: Exploratory analyses of a randomized controlled trial that enrolled 610 participants with nAMD and compared 2 anti-VEGF antibodies, ranibizumab and bevacizumab, and 2 treatment regimens, monthly vs. discontinuous, with 2 years' follow-up. Read More

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February 2018

Autoimmune keratitis in mycobacterium tuberculosis.

J Curr Ophthalmol 2018 Dec 18;30(4):381-383. Epub 2018 May 18.

Department of Ophthalmology, Goethe-University, Frankfurt, Germany.

Purpose: To report a case of autoimmune keratitis in a patient with mycobacterium tuberculosis (MBT).

Methods: An 84-year-old male with pulmonary tuberculosis (TB) was admitted with chronic, non-healing bilateral ulcerations of the inferior peripheral cornea associated with stromal and subconjunctival nodules.

Results: Clinical examination revealed circumscribed peripheral corneal ulceration with whitish nodules in adjacent stromal and subconjunctival tissue. Read More

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December 2018

Total necrosis of cornea, iris and crystalline lens with exposure of vitreous hyaloid face in the context of recalcitrant acanthamoeba keratitis.

J Curr Ophthalmol 2018 Dec 19;30(4):377-380. Epub 2018 Mar 19.

Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To report a rare and complicated case of acanthamoeba keratitis (AK) presented with total necrosis and dislodgment of cornea, iris, and crystalline lens with exposure of vitreous hyaloids face.

Methods: Case report of 28-year-old female referred to the Farabi Eye Hospital with a history of known left eye AK since 4 months earlier. She also had a history of soft contact lens wear for two years and topical steroid use before proper diagnosis. Read More

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December 2018

Use of hyaluronic acid gel filler to improve contact lens wear in patients with deep sunken superior sulcus.

J Curr Ophthalmol 2018 Dec 10;30(4):374-376. Epub 2018 Feb 10.

Advanced Vision Care, Los Angeles, CA, USA.

Purpose: Deep sunken superior sulcus of the upper eyelid can result from aging, genetic, prostaglandin use, and prior aggressive upper blepharoplasty. If severe, it can cause exposure keratopathy, lagophthalmos, and giant fornix syndrome. We herein report on another milder manifestation of deep superior sulcus and its treatments. Read More

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December 2018

Idiopathic macular telangiectasia type 2: A six-year study with multimodal imaging of a presumed unilateral case.

J Curr Ophthalmol 2018 Dec 3;30(4):368-373. Epub 2018 Feb 3.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To present a rare manifestation of macular telangiectasia type 2 (MacTel type 2) followed up for over six years.

Methods: A 61-year-old woman with one year history of blurred vision of her left eye was referred.

Results: Whereas the funduscopy, spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and fundus autofluorescence (FAF) were normal in the right eye, they revealed noticeable findings typical of MacTel type 2 in the left eye. Read More

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December 2018

Value of medical history in ophthalmology: A study of diagnostic accuracy.

J Curr Ophthalmol 2018 Dec 27;30(4):359-364. Epub 2018 Sep 27.

Doheny Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: This study aimed to demonstrate the value of the chief compliant and patient history to accurately diagnose patient pathology without requiring ocular examination or imaging in an outpatient neuro-ophthalmology clinic.

Methods: We prospectively evaluated 115 consecutive patients at our institution from January to April 2009. The attending neuro-ophthalmologist committed to a single most likely diagnosis while solely being exposed to patient demographic information (age, gender, race) and chief complaint, but was otherwise blinded to ocular examination or imaging. Read More

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December 2018

The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran.

J Curr Ophthalmol 2018 Dec 19;30(4):353-358. Epub 2018 Jul 19.

Eye Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Purpose: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran.

Methods: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March 2014 were enrolled in this cross-sectional study. The measurements of proptosis, lid width, lagophthalmos, extraocular muscle function, and visual acuity were recorded. Read More

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December 2018

The newborn conjunctival flora at the post delivery 24 hours.

J Curr Ophthalmol 2018 Dec 10;30(4):348-352. Epub 2018 Apr 10.

Department of Microbiology, Kayseri Training and Education Hospital, Kayseri, Turkey.

Purpose: The aim of this study was to investigate the aerobic conjunctival flora of neonates and the effects of delivery type on conjunctival flora development in neonates who were born with normal spontaneous vaginal delivery (SVD) or elective caesarean section (C/S) and who were not given prophylactic antibiotic eye drops after birth.

Methods: This cross-sectional study included 95 healthy newborns. One day after the delivery, conjunctival samples were taken from newborns who were born with normal SVD or elective C/S, and not given prophylactic antibiotic eye drops after birth. Read More

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December 2018

Comparison of two methods for measuring contrast sensitivity in anisometropic amblyopia.

J Curr Ophthalmol 2018 Dec 27;30(4):343-347. Epub 2018 Apr 27.

Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: This study aimed to evaluate two psychophysical contrast sensitivity testing methods in amblyopic patients.

Methods: Thirty-three adults with anisometropic amblyopia participated in this study. Psychophysical contrast sensitivity was measured for both amblyopic and fellow eyes of the participants at 1, 3, and 5 cycles per degree (cpd) spatial frequencies by Freiburg visual acuity and contrast test (FrACT) and Metrovision contrast sensitivity test, which employ sine-wave gratings for measurement of contrast sensitivity. Read More

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December 2018

Influence of standard corneal cross-linking in keratoconus patients on macular profile.

J Curr Ophthalmol 2018 Dec 29;30(4):330-336. Epub 2018 Jun 29.

Department of Ophthalmology, Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: To determine the effect of corneal cross-linking (CXL) on retinal structure and function.

Methods: The current study was conducted on 42 eyes of 21 patients with keratoconus (KCN) who were candidates for CXL due to disease progression. The Optovue optical coherence tomography (OCT) (Optovue Inc. Read More

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December 2018

Evaluation of the effects of isotretinoin for treatment of acne on corneal sensitivity.

J Curr Ophthalmol 2018 Dec 6;30(4):326-329. Epub 2018 Sep 6.

Department of Optometry, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To determine the effect of isotretinoin on corneal sensitivity in acne patients.

Methods: Fifty patients (13 men and 37 women) with a mean age of 23.24 ± 3. Read More

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December 2018

Association between dry eye symptoms and signs.

J Curr Ophthalmol 2018 Dec 28;30(4):321-325. Epub 2018 Jun 28.

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.

Purpose: To evaluate the association between subjective dry eye symptoms and the results of the clinical examinations.

Methods: The study was a clinical-based survey involving 215 first-year students selected consecutively during a regular ocular health examination at the University of Cape Coast Optometry Clinic. The data collection process spanned for a period of four months. Read More

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December 2018

Deep anterior lamellar keratoplasty: A surgeon's guide.

J Curr Ophthalmol 2018 Dec 10;30(4):297-310. Epub 2018 Jul 10.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom.

Purpose: To review and highlight important practical aspects of deep anterior lamellar keratoplasty (DALK) surgery and provide some useful tips for surgeons wishing to convert to this procedure from the conventional penetrating keratoplasty (PK) technique.

Methods: In this narrative review, the procedure of DALK is described in detail. Important pre, intra, and postoperative considerations are discussed with illustrative examples for better understanding. Read More

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December 2018

MEWDS is a true primary choriocapillaritis and basic mechanisms do not seem to differ from other choriocapillaritis entities.

J Curr Ophthalmol 2018 Dec 15;30(4):281-286. Epub 2018 Nov 15.

Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialised Care Montchoisi Teaching Centre, Lausanne, Switzerland.

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December 2018

Development of a dural arteriovenous fistula subsequent to cerebral venous thrombosis by venous hypertension.

eNeurologicalSci 2019 Mar 22;14:24-27. Epub 2018 Nov 22.

Department of Neurology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.

Dural arteriovenous fistulas (dAVF) refer to an aberrant connection between an artery and a vein within the dura. Although the pathogenesis of dAVF is unclear, a link to cerebral venous thrombosis (CVT) has been posited though not fully identified. The current case is the first report demonstrating dAVF formation following CVT according to dynamic changes in the intracranial pressure and venous drainage pattern. Read More

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Lifitegrast add-on treatment for dupilumab-induced ocular surface disease (DIOSD): A novel case report.

JAAD Case Rep 2019 Jan 4;5(1):34-36. Epub 2018 Dec 4.

Comprehensive Eye Care of Central Ohio, Westerville, Ohio.

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January 2019

Management of malignant carinal involvement using 'side-by-side' method of bilateral self-expandable metallic stents.

Respirol Case Rep 2019 Feb 10;7(2):e00396. Epub 2018 Dec 10.

Department of Respiratory Medicine Uji-Tokushukai Medical Center Kyoto Japan.

Central airway obstruction caused by cancer requires urgent interventional pulmonology. Malignant main carinal involvement is one of the most challenging situations, usually treated by rigid bronchoscopic intervention under general anaesthesia. However, these patients tend to be in poor condition due to underlying malignancy. Read More

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February 2019

Improvement Efficacy of Influenza Nanovaccine in Combination with Hemokinin-1 Molecular Adjuvant.

Avicenna J Med Biotechnol 2018 Oct-Dec;10(4):208-213

Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Background: H9N2 avian influenza viruses have the potential to become the next human pandemic threat and next generation vaccine technologies are needed. Current studies introduce nanoparticles as a proper vaccine delivery vehicle for induction of protective immunity. In this study, the efficacy of chitosan nanoparticle-based H9N2 influenza vaccine with and without hemokinin-1 (HK-1) as a molecular adjuvant to induce protective immunity against the virus was examined. Read More

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December 2018

Just flip it!-CRT implantation in a patient with dextrocardia and situs inversus totalis.

J Arrhythm 2018 Dec 6;34(6):656-658. Epub 2018 Oct 6.

Heart Rhythm Services - St-Paul's Hospital University of British Columbia Vancouver BC Canada.

Implantation of a cardiac resynchronization therapy (CRT) device in patients with congenital heart disease may be challenging because of the particular underlying anatomy. We present the case of a right-sided transvenous implantation of a dual-chamber CRT-D device in a patient with situs inversus totalis and mirror image dextrocardia. To facilitate our anatomic orientation and to overcome unusual hand-eye coordination problems, we decided to flip the fluoroscopic image projection by 180° (right-left), creating the optical impression of a "normalized" heart position (levocardia). Read More

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December 2018

Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics.

Theranostics 2018 5;8(20):5529-5547. Epub 2018 Nov 5.

Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to translate into clinical success due to their nonspecific cellular localization, poor transport properties across multiple biological barriers, and associated side effects. These challenges, coupled with the complex function of the mitochondria, create the need for innovative delivery strategies. Read More

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November 2018

Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome.

Front Microbiol 2018 4;9:3005. Epub 2018 Dec 4.

Howe Laboratory, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.

[This corrects the article DOI: 10.3389/fmicb.2018. Read More

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December 2018

A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel.

Front Endocrinol (Lausanne) 2018 30;9:721. Epub 2018 Nov 30.

Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.

Multiple gonadotropin-releasing hormone receptors (GnRHRs) are present in vertebrates, but their differential physiological relevances remain to be clarified. In the present study, we identified three GnRH ligands GnRH1 (pjGnRH), GnRH2 (cGnRH-II), and GnRH3 (sGnRH) from the brain, and two GnRH receptors GnRHR1 (GnRHR IIa) and GnRHR2 (GnRHR IIb) from the pituitary of the ricefield eel . GnRH1 and GnRH3 but not GnRH2 immunoreactive neurons were detected in the pre-optic area, hypothalamus, and pituitary, suggesting that GnRH1 and GnRH3 may exert hypophysiotropic roles in ricefield eels. Read More

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November 2018

Central Nervous System Involvement in Common Variable Immunodeficiency: A Case of Acute Unilateral Optic Neuritis in a 26-Year-Old Italian Patient.

Front Neurol 2018 30;9:1031. Epub 2018 Nov 30.

Neurology Unit, Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Centre, Neuroscience Section, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Common Variable Immunodeficiency (CVID) is a group of heterogeneous primary immunodeficiencies sharing defective B lymphocytes maturation and dysregulated immune response and resulting in impaired immunoglobulin production. Clinical picture encompasses increased susceptibility to infections, hematologic malignancies, inflammatory, and autoimmune diseases. Neurological manifestations are uncommon and optic neuritis has been previously reported only in one case with bilateral involvement. Read More

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November 2018

Physical Cue Influences Children's Empathy for Pain: The Role of Attention Allocation.

Front Psychol 2018 30;9:2378. Epub 2018 Nov 30.

School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.

Empathy for pain is evolutionally important and context-dependent. The current study explored the effect of physical cue on 4- to 5-year-old children's empathy for pain with two experiments. Experiment 1 investigated the effect of valid and invalid physical cue as compared to baseline (without cue) in pain evaluation task (evaluating the pain intensity of a facial expression, = 28). Read More

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November 2018

Transcranial Direct Current Stimulation Does Not Counteract Cognitive Fatigue, but Induces Sleepiness and an Inter-Hemispheric Shift in Brain Oxygenation.

Front Psychol 2018 30;9:2351. Epub 2018 Nov 30.

UR2NF, Neuropsychology and Functional Neuroimaging Research Unit, Centre de Recherches en Cognition et Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Sustained cognitive demands may result in cognitive fatigue (CF), eventually leading to decreased behavioral performance and compromised brain resources. In the present study, we tested the hypothesis that transcranial direct current stimulation (tDCS) would counteract the behavioral and neurophysiological effects of CF. Twenty young healthy participants were tested in a within-subject counterbalanced order across two different days. Read More

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November 2018
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