544 results match your criteria Optic Neuropathy Compressive


Spontaneous orbital decompression in thyroid eye disease: new measurement methods and its influential factors.

Graefes Arch Clin Exp Ophthalmol 2020 May 25. Epub 2020 May 25.

Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Purpose: To evaluate spontaneous decompression of the medial orbital wall and orbital floor in thyroid eye disease using new measurement methods and to analyze the influential factors.

Methods: This retrospective study included 86 patients (172 sides). Regarding evaluation of spontaneous medial orbital decompression, an anteroposterior line was drawn between the posterior lacrimal crest and the junction between the ethmoid bone and corpus ossis sphenoidalis. Read More

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http://dx.doi.org/10.1007/s00417-020-04762-0DOI Listing

Good Visual Outcome Following Corticosteroid Treatment for Compressive Optic Neuropathy Secondary to Sinonasal Carcinoma.

Cureus 2020 Apr 18;12(4):e7732. Epub 2020 Apr 18.

Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Most patients with sinonasal carcinoma present to the otorhinolaryngologist with nasal symptoms. It is however uncommon for them to present with acute visual loss at first presentation. We report a case of compressive optic neuropathy secondary to sinonasal carcinoma, which presented acutely with right eye blurring of vision upon waking up. Read More

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http://dx.doi.org/10.7759/cureus.7732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237059PMC

Bruch's Membrane Opening Minimum Rim Width in the Differential Diagnosis of Optic Neuropathies.

Neuroophthalmology 2020 Apr 21;44(2):76-88. Epub 2019 Aug 21.

Ophthalmology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Porto, Portugal.

Observing optic disc pallor during a patient's first visit frequently raises a diagnostic challenge, particularly in regards to whether the cause is due to glaucoma or another form of optic neuropathy. Bruch's membrane opening (BMO) was recently discovered as the anatomical border of the optic disc. BMO minimum rim width (BMO-MRW) seems to be a reliable representation of the neuroretinal rim. Read More

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http://dx.doi.org/10.1080/01658107.2019.1650075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202433PMC

Optic Neuropathy Due to Compression by an Ectatic Internal Carotid Artery Within the Orbital Apex.

J Neuroophthalmol 2020 May 1. Epub 2020 May 1.

Departments of Radiology (MTC, AAZ) and Neurosurgery (RD), Brigham and Women's Hospital, Boston, Massachusetts; and Department of Neurology (SP), Division of Neuro-Ophthalmology, Brigham and Women's Hospital, Boston, Massachusetts.

Neurovascular compression is a rare but potentially treatable cause of optic neuropathy. Although incidental contact of the cisternal optic nerve and internal carotid artery (ICA) is common, compressive optic neuropathy occurring within the orbital apex has not been comprehensively described. We report a case of intra-orbital and intracanalicular optic nerve compression due to an ectatic ICA in a patient with congenital absence of the contralateral ICA. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000975DOI Listing

Orbital and Eyelid Inflammation With "Muciphages" and Extravasated Mucin From an Ethmoido-orbital Mucocele.

Ophthalmic Plast Reconstr Surg 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology.

A 22-year-old woman presented with an acute compressive optic neuropathy due to a ruptured ethmoido-orbital mucocele. She underwent urgent orbital decompression and drainage of the mucocele via an endoscopic approach. Postoperatively, her course was complicated by an orbital compartment syndrome supervened, exhibiting severe eyelid edema caused by infiltration with mucin and mucin-containing macrophages ("muciphages"). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001685DOI Listing
April 2020
0.914 Impact Factor

Thyroid eye disease with choroidal folds.

Orbit 2020 Apr 23:1-9. Epub 2020 Apr 23.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

: To determine the clinical course of patients with chorioretinal folds (CRF) in thyroid eye disease (TED).: A multi-center retrospective case series of patients with TED who developed CRF.: Ten patients (17 eyes) with CRF related to TED were identified. Read More

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http://dx.doi.org/10.1080/01676830.2020.1756347DOI Listing

Visual Outcomes After Endoscopic Endonasal Resection of Orbital Lesions.

World Neurosurg 2020 Apr 18. Epub 2020 Apr 18.

Division of Neurosurgery, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: The endoscopic endonasal approach (EEA) has been increasing in popularity as an alternative to traditional transcranial and transorbital approaches in the treatment of orbital pathological entities. The purpose of the present study was to examine the outcomes of patients who had undergone EEA resection of orbital lesions at our center.

Methods: We performed a retrospective medical record review of patients who had undergone the EEA for resection of orbital lesions and orbital apex decompression from January 1, 2006 to December 1, 2019. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.050DOI Listing

Prognostic value of macular ganglion cell layer thickness for visual outcome in parasellar tumors.

J Neurol Sci 2020 Apr 6;414:116823. Epub 2020 Apr 6.

Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Purpose: Optic nerve compression by mass lesions at the optic chiasm leads to loss of visual function which can be recovered after decompression surgery. In this study, we evaluated the prognostic ability of macular ganglion cell layer (mGCL) thickness measured with spectral-domain optical coherence tomography (SD-OCT) for predicting postoperative visual outcome of compressive optic neuropathy (CON) related to parasellar tumors.

Methods: This observational cohort study used data from the Department of Neurosurgery and Ophthalmology, Seoul National University Bundang Hospital between 2013 and 2018. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116823DOI Listing

Neuro-Ophthalmic Manifestations of Intracranial Malignancies.

J Neuroophthalmol 2020 Apr 6. Epub 2020 Apr 6.

Department of Ophthalmology (CRD, AGL), Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; Blanton Eye Institute (ATK, BAAO, AGL), Houston Methodist Hospital, Houston, Texas; and Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (AGL), UT MD Anderson Cancer Center, Houston, Texas; Department of Ophthalmology (AGL), Texas A and M College of Medicine, College Station, Texas; Department of Ophthalmology (AGL), University of Iowa Hospitals and Clinics, Iowa City, Iowa; Department of Ophthalmology (AGL), University of Buffalo, Buffalo, New York.

Background: To describe the various neuro-ophthalmic presentations, key exam features, and clinical findings associated with 5 common primary and secondary intracranial malignancies.

Evidence Acquisition: Retrospective PubMed search and review of published case reports, case series, observational studies, book chapters, and review articles examining the neuro-ophthalmic features of intracranial malignancies including primary glial neoplasms (e.g. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000950DOI Listing

Morphometric, Hemodynamic, and Biomechanical Factors Influencing Blood Flow and Oxygen Concentration in the Human Lamina Cribrosa.

Invest Ophthalmol Vis Sci 2020 Apr;61(4)

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Purpose: We developed a combined biomechanical and hemodynamic model of the human eye to estimate blood flow and oxygen concentration within the lamina cribrosa (LC) and rank the factors that influence LC oxygen concentration.

Methods: We generated 5000 finite-element eye models with detailed microcapillary networks of the LC and computed the oxygen concentration of the lamina retinal ganglion cell axons. For each model, we varied the intraocular pressure (IOP) from 10 mm Hg to 55 mm Hg in 5-mm Hg increments, the cerebrospinal fluid pressure (13 ± 2 mm Hg), cup depth (0. Read More

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http://dx.doi.org/10.1167/iovs.61.4.3DOI Listing

Endoscopic-Assisted Lateral Orbitotomy for Large Orbital Roof Dermoid Cysts With Dural Invasion.

Ophthalmic Plast Reconstr Surg 2020 Apr 6. Epub 2020 Apr 6.

Eye Department, Eye and Skull Base Research Center, The Five Senses Institute, Iran University of Medical Science, Tehran, Iran.

Purpose: To demonstrate the technique and report the results of endoscopic-assisted lateral orbitotomy for 6 patients with huge intraorbital dermoid cyst causing orbital roof bone erosion and dural invasion.

Methods: Patients had unilateral cystic tumor with proptosis and hypoglobus for more than 6 months. There was no compressive optic neuropathy. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001661DOI Listing

Hyperostosing sphenoid wing meningiomas: surgical outcomes and strategy for bone resection and multidisciplinary orbital reconstruction.

J Neurosurg 2020 Mar 6:1-10. Epub 2020 Mar 6.

Departments of1Neurological Surgery.

Objective: Hyperostosing sphenoid wing meningiomas cause bony hyperostosis that may extend into the orbit, resulting in proptosis, restriction of extraocular movements, and/or compressive optic neuropathy. The extent of bony removal necessary and the optimal reconstruction strategy to prevent enophthalmos is debated. Herein, the authors present their surgical outcomes and reconstruction results. Read More

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http://dx.doi.org/10.3171/2019.12.JNS192543DOI Listing

Endoscopic Optic Nerve Decompression for Optic Neuropathy in Sinonasal Fibro-Osseous Tumors.

World Neurosurg 2020 Feb 24. Epub 2020 Feb 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: Sinonasal fibro-osseous tumors involving the skull base sometimes result in the encasement of the optic canal and can cause the compressive optic neuropathy. This study aimed to elucidate the optimal timing of endoscopic optic nerve decompression (OND) in cases with optic neuropathy caused by fibro-osseous tumors.

Methods: Medical records were reviewed retrospectively from July 2008 through November 2016. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.080DOI Listing
February 2020

Discriminating glaucomatous and compressive optic neuropathy on spectral-domain optical coherence tomography with deep learning classifier.

Br J Ophthalmol 2020 Feb 25. Epub 2020 Feb 25.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea

Background/aims: To assess the performance of a deep learning classifier for differentiation of glaucomatous optic neuropathy (GON) from compressive optic neuropathy (CON) based on ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) spectral-domain optical coherence tomography (SD-OCT).

Methods: Eighty SD-OCT image sets from 80 eyes of 80 patients with GON along with 81 SD-OCT image sets from 54 eyes of 54 patients with CON were compiled for the study. The bottleneck features extracted from the GCIPL thickness map, GCIPL deviation map, RNFL thickness map and RNFL deviation map were used as predictors for the deep learning classifier. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314330DOI Listing
February 2020

Intraorbital Steroid Injection for Active Thyroid Ophthalmopathy.

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):69-77. Epub 2020 Feb 2.

Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the effect of orbital steroid injections in patients with active thyroid ophthalmopathy resistant to or dependent on systemic steroids, or with complications related to systemic steroid use.

Methods: This prospective non-comparative case series includes 31 eyes of 17 patients with active thyroid ophthalmopathy and clinical activity score (CAS) of 3 or more, without compressive optic neuropathy or overt exposure keratopathy. All subjects had a history of previous systemic steroid use (with steroid resistance or dependence) or had developed complications related to steroids. Read More

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http://dx.doi.org/10.18502/jovr.v15i1.5948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001014PMC
February 2020

Severe visual impairment due to an optic neuropathy and central retinal vein occlusion in a sarcoidosis patient.

Authors:
Miki Hiraoka

J Ophthalmic Inflamm Infect 2020 Jan 31;10(1). Epub 2020 Jan 31.

Department of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.

Background: The ophthalmic manifestation of neurosarcoidosis is varied. The complication of optic neuropathy and central retinal vein occlusion (CRVO) is rare in sarcoidosis.

Case Report: The patient was a 55-year-old female with systemic sarcoidosis suffering from visual loss as hand motion in her left eye. Read More

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http://dx.doi.org/10.1186/s12348-020-0198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992815PMC
January 2020

Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients.

Graefes Arch Clin Exp Ophthalmol 2020 Feb 18;258(2):419-425. Epub 2019 Dec 18.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Aims: To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function.

Methods: A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. Read More

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http://dx.doi.org/10.1007/s00417-019-04560-3DOI Listing
February 2020

A Nomenclature to Describe the Sequence of Visual Field Defects in Progressive Thyroid Eye Disease-Compressive Optic Neuropathy (An American Ophthalmological Society Thesis).

Am J Ophthalmol 2020 May 13;213:293-305. Epub 2019 Dec 13.

Department of Ophthalmology, Somdech Phrapinklao Hospital, Royal Thai Navy, Bangkok, Thailand.

Purpose: To create a novel nomenclature to characterize the longitudinal sequence of visual field (VF) defects in patients with progression of thyroid eye disease-compressive optic neuropathy (TED-CON).

Methods: A retrospective review of records from 1 institution identified patients with progressive Humphrey VF defects secondary to TED-CON. The VF defects were analyzed by 2 independent reviewers and classified into 1 of 10 categories, divided into 3 stages that reflect the observed progression pattern, plus a miscellaneous category (stage X). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.12.005DOI Listing

Patients With Isolated Craniofacial Dysplasia Report Better Quality of Life Compared With Those With Craniofacial Dysplasia and Extracranial Involvement.

Ophthalmic Plast Reconstr Surg 2020 May/Jun;36(3):292-297

Department of Medicine, Division Endocrinology.

Purpose: Craniofacial fibrous dysplasia (CFD) is a subtype of fibrous dysplasia/McCune-Albright syndrome (FD/MAS) characterized by FD lesions in one or more of the skull bones. The orbit is often involved, with facial pain, facial deformity, and increased risk of compressive optic neuropathy as associated clinical manifestations possibly leading to altered illness perceptions and impairments in quality of life(QoL). The aim of this study was to evaluate illness perceptions and QoL in patients with CFD among our FD/MAS cohort. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001536DOI Listing
December 2019

Retinal microvasculature in pituitary adenoma patients: is optical coherence tomography angiography useful?

Acta Ophthalmol 2019 Dec 6. Epub 2019 Dec 6.

Ophthalmology Department, AP-HP, Sorbonne Université, Paris, France.

Purpose: To examine retinal vascular changes in the peripapillary and macular areas in patients with pituitary adenoma (PA) using optical coherence tomography angiography (OCTA).

Methods: Cross-sectional, retrospective study of 17 consecutive PA patients and 16 healthy subjects. All patients underwent a neuro-ophthalmological examination to assess the presence of optic neuropathy (ON). Read More

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http://dx.doi.org/10.1111/aos.14322DOI Listing
December 2019

Melanocytoma of the optic disk: A review.

Indian J Ophthalmol 2019 12;67(12):1949-1958

Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. Today, however, it is generally recognized by its typical clinical features that differ from most melanomas and erroneous enucleation is rarely done. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2039_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896535PMC
December 2019

Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis.

Clin Ophthalmol 2019 22;13:1599-1608. Epub 2019 Aug 22.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: To illustrate the structure-function relationship of compressive optic neuropathy (CON) at the time of diagnosis.

Patients And Methods: Thirty-two eyes of newly diagnosed suprasellar CON and 60 healthy eyes were included in the study. The peripapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell-inner plexiform layer (GCIPL) thickness were obtained using Cirrus spectral domain optical coherence tomography (SD-OCT). Read More

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http://dx.doi.org/10.2147/OPTH.S215115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709828PMC

[Optic neuropathy from connected intra- and extraorbital lesions in IgG4-related disease].

Rinsho Shinkeigaku 2019 Nov 26;59(11):746-751. Epub 2019 Oct 26.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine.

We present the case of a 74-year-old woman complaining of blurred vision in the left eye who was found to have a unilateral, continuous lesion of the optic nerve and nerve sheath accompanied by an intracranial mass next to the cavernous sinus and meninges. Surgical decompression of the left optic nerve in the optic canal and partial resection of the mass followed by prednisolone administration were successful. Immunohistochemical analysis disclosed abundant infiltration of IgG4-positive plasma cells at >10 cells/high power field. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001342DOI Listing
November 2019

Rathke's Cleft Cyst Apoplexy in Two Teenage Sisters.

Pediatr Neurosurg 2019 21;54(6):428-435. Epub 2019 Oct 21.

Department of Neurosurgery, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA,

Rathke's cleft cysts (RCC) are sellar-suprasellar cysts that are usually discovered incidentally given their indolent clinical course. When symptoms do arise, the most common clinical presentation is headache, visual field deficits due to visual pathway compression, diplopia due to cavernous sinus compression, chemical meningitis due to spillage of the cyst contents, endocrine dysfunction, and very rarely apoplexy. We present 2 cases of RCC in sisters who developed a sudden onset of symptoms in a manner similar to pituitary apoplexy. Read More

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http://dx.doi.org/10.1159/000503112DOI Listing

Effects of Orbital Decompression on Lamina Cribrosa Depth in Patients with Graves' Orbitopathy.

Korean J Ophthalmol 2019 Oct;33(5):436-445

Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We sought to investigate the effects of Graves' orbitopathy (GO) and orbital decompression on lamina cribrosa depth (LCD) using spectral-domain optical coherence tomography.

Methods: Forty eyes that underwent orbital decompression to relieve compressive optic neuropathy or correct disfiguring exophthalmos in the context of GO were included. Subjects were imaged with spectral-domain optical coherence tomography before surgery and at 1 and 3 months after surgery, at which the examiner measured the LCD (distance from the anterior surface of the lamina cribrosa to the Bruch membrane opening line) and peripapillary retinal nerve fiber layer thickness. Read More

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http://dx.doi.org/10.3341/kjo.2019.0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791952PMC
October 2019
4 Reads

Compressive optic neuropathy secondary to orbital inflammation with ophthalmic artery dolichoectasia.

J Fr Ophtalmol 2019 11 4;42(9):e435-e437. Epub 2019 Oct 4.

Department of Internal Medicine, Fondation Ophtalmologique Adolphe de Rothschild, 75019 Paris, France.

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http://dx.doi.org/10.1016/j.jfo.2019.01.012DOI Listing
November 2019

Compressive optic neuropathy with vision loss due to IgG4-related orbital disease.

Orbit 2019 Oct 8. Epub 2019 Oct 8.

Department of Ophthalmology, SUNY Downstate Medical Center , Brooklyn , New York , USA.

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https://www.tandfonline.com/doi/full/10.1080/01676830.2019.1
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http://dx.doi.org/10.1080/01676830.2019.1672752DOI Listing
October 2019
3 Reads

Vision loss associated with orbital surgery - a major review.

Orbit 2020 Jun 1;39(3):197-208. Epub 2019 Oct 1.

Department of Ophthalmology, National University Hospital, National University of Singapore, Singapore.

: Vision loss after orbital surgery is one of the most dreaded complications faced by the orbitofacial surgeon. This literature review was conducted in an attempt to determine the risk factors for severe vision loss and discuss the applied anatomy related to various types of orbital surgery - orbital tumor excisions, orbital decompression, and post-traumatic orbital reconstruction.: A literature search was conducted via PubMed and Google Scholar. Read More

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http://dx.doi.org/10.1080/01676830.2019.1658790DOI Listing
June 2020
3 Reads

Etiological Spectrum of Non-compressive Myelopathies in Tertiary Care Centre.

J Assoc Physicians India 2019 Sep;67(9):14-16

Senior Resident.

Aims: To study the clinical, radiological, cerebrospinal fluid profile of noncompressive myelopathy and to study various etiologies of non-compressive myelopathies in causation of quadriplegia and paraplegia.

Study Design: Observational study.

Place And Duration Of Study: Department of Neurology, Govt. Read More

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September 2019
2 Reads

Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss.

Eye (Lond) 2020 Apr 18;34(4):695-703. Epub 2019 Sep 18.

Division of Ophthalmology and the Laboratory of Investigation in Ophthalmology (LIM 33), University of São Paulo, São Paulo, Brazil.

Aims: To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss.

Methods: Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. Read More

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http://dx.doi.org/10.1038/s41433-019-0564-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093447PMC
April 2020
2 Reads

Isolated Optic Perineuritis as the Presenting Sign of Sarcoidosis.

J Neuroophthalmol 2020 Jun;40(2):255-257

Division of Neurology, Department of Medicine, Department of Ophthalmology and Vision Sciences (JAM), University of Toronto, Toronto, Canada; Kensington Vision and Research Centre (JAM), Toronto, Canada; Department of Ophthalmology (JAM), St. Michael's Hospital, Toronto, Canada; Department of Laboratory Medicine (CJS), St. Michael's Hospital, Toronto, Canada; and Division of Respirology (KM), Department of Medicine, University of Toronto, St. Michael's Hospital, Toronto, Canada.

A 35-year-old healthy African-American woman presented with a 4-month history of gradual loss of vision in the right eye from an optic neuropathy. MRI of the orbits with gadolinium showed isolated thickening and enhancement of the right optic nerve sheath. Chest x-ray and CT-scan of the chest were performed and showed bilateral hilar and mediastinal lymphadenopathy. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9911
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http://dx.doi.org/10.1097/WNO.0000000000000822DOI Listing
June 2020
3 Reads

Optic Neuropathy, Secondary to Ethmoiditis, and Onodi Cell Inflammation during Childhood: A Case Report and Review of the Literature.

Neuropediatrics 2019 12 22;50(6):341-345. Epub 2019 Jul 22.

ENT Unit, Department of Otorhinolaryngology, University of Catania, Italy.

Optic neuropathy consists of several etiological events. The primary etiologies of its acute form include optic neuritis, ischemic optic neuropathy, inflammatory (nondemyelinating) disorders, and trauma. Its subacute and chronic forms are most often linked to compressive, toxic, nutritional, or hereditary-genetic causes. Read More

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http://dx.doi.org/10.1055/s-0039-1693156DOI Listing
December 2019
10 Reads

Osteopetrosis craniopathy: a rare cause of bilateral compressive optic neuropathy and facial nerve palsy.

Postgrad Med J 2019 Sep 10;95(1127):513. Epub 2019 Jul 10.

UM Eye Research Centre, University of Malaya Faculty of Medicine, Kuala Lumpur, Malaysia

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http://dx.doi.org/10.1136/postgradmedj-2019-136527DOI Listing
September 2019
9 Reads

Compressive optic neuropathy secondary to an allergic reaction to hyaluronidase.

Arch Soc Esp Oftalmol 2019 Sep 4;94(9):441-444. Epub 2019 Jul 4.

Centre Ocular Quirúrgic de Sant Boi, Sant Boi de Llobregat, Barcelona, España.

A 58 year-old woman presented with severe chemosis and ophthalmoparesis on her left eye 8hours after uncomplicated cataract surgery under sub-tenon anaesthesia. Recovery of extrinsic motility was observed after corticosteroid and antihistamine treatment, but a non-haemorrhagic papillary oedema and a concentric defect of visual field were found. It progressed to papillary atrophy with preserved central vision, but with a significant visual field constriction. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.03.017DOI Listing
September 2019
6 Reads

Outcomes of endoscopic orbital decompression for graves' ophthalmopathy.

Ir J Med Sci 2020 Feb 16;189(1):177-183. Epub 2019 Jun 16.

Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland.

Background/aims: We assess outcomes of endoscopic orbital decompression for Graves' ophthalmopathy.

Methods: A review of endoscopic orbital decompressions of the medial and partial inferior wall between July 2004 and July 2017 was carried out. Outcome was assessed by comparing pre- and post-operative measurements of exophthalmometry and visual acuity. Read More

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http://dx.doi.org/10.1007/s11845-019-02043-2DOI Listing
February 2020
11 Reads

Magnetic resonance imaging in myelopathy: a pictorial review.

Clin Imaging 2019 Sep - Oct;57:56-68. Epub 2019 May 17.

Department of Radiology, George Washington University, Washington DC, and MedPix®, National Library of Medicine, Bethesda, MD, United States of America.

Myelopathies have multiple causes and broad differential diagnoses, including demyelinating, metabolic, vascular and neoplastic disorders, often with distinctive imaging manifestations. Compressive myelopathy, especially of degenerative and neoplastic origin, is the most common cause of myelopathy, followed by inflammatory disorders such as multiple sclerosis, acute disseminating encephalomyelitis, neuromyelitis optica, and transverse myelitis of other etiologies. An accurate and early diagnosis will guide the treatment and will provide information about the prognosis of the patient. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.05.002DOI Listing
January 2020
1 Read

Interventions for orbital lymphangioma.

Cochrane Database Syst Rev 2019 05 15;5:CD013000. Epub 2019 May 15.

Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, 3rd Floor, Bronx, NY, USA, 10467.

Background: Orbital lymphangiomas are a subset of localized vascular and lymphatic malformations, which most commonly occur in the head and neck region. Orbital lymphangiomas typically present in the first decade of life with signs of ptosis, proptosis, restriction of ocular motility, compressive optic neuropathy, and disfigurement. Therefore, early and effective treatment is crucial to preserving vision. Read More

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http://dx.doi.org/10.1002/14651858.CD013000.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521140PMC
May 2019
11 Reads

Visual field and orbital computed tomography correlation in dysthyroid optic neuropathy due to thyroid eye disease.

Orbit 2020 Apr 6;39(2):77-83. Epub 2019 May 6.

Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.

: The pathogenesis of dysthyroid optic neuropathy (DON) in thyroid eye disease (TED) is thought to be compression of the apical optic nerve by hypertrophied extraocular muscles. We correlated worsening DON to the area occupied by extraocular muscles.: Records of adults with TED DON evaluated from 1/1/2013 to 1/1/2018 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/01676830.2019.1600150DOI Listing
April 2020
8 Reads

Compressive optic neuropathy in non-thyroidal lymphocytic infiltrative disorders of the extraocular muscles.

Can J Ophthalmol 2019 04 31;54(2):e81-e84. Epub 2018 Aug 31.

Department of Oculoplastic, Orbital, and Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.

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http://dx.doi.org/10.1016/j.jcjo.2018.06.012DOI Listing
April 2019
7 Reads

[Acute visual loss related to sphenoid meningioma].

J Fr Ophtalmol 2019 May 27;42(5):485-491. Epub 2019 Mar 27.

Département d'ophtalmologie, DHU vision et handicaps, hôpital Pitié-Salpêtrière, 47-92, boulevard de l'Hopital, 75013 Paris, France. Electronic address:

Meningiomas represent about 20% of intracranial tumors. Involvement of the medial sphenoid wing includes anterior clinoid, cavernous sinus and superior orbital fissure meningiomas. Due to the proximity of these tumors to the optic nerve, typically progressive unilateral vision loss, over several months to years, is the classic clinical presentation. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.12.006DOI Listing
May 2019
13 Reads

Correlation of peripapillary nerve fiber layer thickness with visual outcomes after decompression surgery in subclinical and clinical thyroid-related compressive optic neuropathy.

J Curr Ophthalmol 2019 Mar 21;31(1):86-91. Epub 2018 Dec 21.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To assess the correlation of peripapillary retinal nerve fiber layer (PRNFL) thickness with visual recovery in compressive optic neuropathy (CON) in patients with thyroid eye disease (TED).

Methods: Twenty-three eyes of 13 consecutive patients with TED-related CON were prospectively recruited. Assessment of PRNFL by means of spectral domain optical coherence tomography (SD-OCT), visual field (VF) parameters, color vision, and visual acuity in logMAR were compared before and 6 months after decompression surgery in the operated eye for each patient, which in ten cases included both eyes. Read More

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http://dx.doi.org/10.1016/j.joco.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407141PMC
March 2019
28 Reads

Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation.

Invest Ophthalmol Vis Sci 2019 03;60(4):913-920

Department of Biomedical Engineering, Ohio State University, Columbus, Ohio, United States.

Purpose: To measure the deformation of the human optic nerve head (ONH) and peripapillary tissue (PPT) in response to acute intraocular pressure (IOP) elevation.

Methods: The ONH and PPT of 14 human donor globes were imaged with high-frequency ultrasonography during inflation testing from 5 to 30 mm Hg. A correlation-based speckle tracking algorithm was used to compute tissue displacements, and the through-thickness, in-plane, and shear strains were calculated by using least-squares strain estimation methods. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-26071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402264PMC
March 2019
21 Reads
3.404 Impact Factor

Yield of screening blood work and MRI of the brain and orbits in the work-up of unilateral chronic optic neuropathy.

Eye (Lond) 2019 06 13;33(6):974-979. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

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http://dx.doi.org/10.1038/s41433-018-0326-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707300PMC
June 2019
12 Reads

[Etiology and diagnostics of compressive optic neuropathies].

Vestn Oftalmol 2018;134(6):72-82

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Purpose: To determine the causes and study the clinical manifestations of compressive optic neuropathy (CON).

Material And Methods: The study included 24 male and 36 female patients with CON (in total 60 patients, 97 eyes). All patients underwent standard ophthalmic examination, as well as computer perimetry, magnetic resonance imaging (MRI), and/or computed tomography (CT) of the brain and orbit and magnetic resonance angiography (MRA). Read More

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http://dx.doi.org/10.17116/oftalma201813406172DOI Listing
July 2019
8 Reads

Methotrexate as an Adjuvant in Severe Thyroid Eye Disease: Does It Really Work as a Steroid-Sparing Agent?

Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):369-373

Oculoplastic Department, Singapore National Eye Centre, Singapore.

Purpose: To compare the efficacy and safety of adjunctive oral methotrexate with intravenous pulsed methylprednisolone against methylprednisolone alone in the treatment of severe thyroid eye disease.

Methods: Retrospective review of clinical data of patients with severe sight-threatening thyroid eye disease with compressive optic neuropathy treated with methylprednisolone with and without methotrexate. Eye disease outcome measures (e. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001279DOI Listing
December 2019
9 Reads

Erotic asphyxiation: May have you seeing double.

Am J Ophthalmol Case Rep 2019 Mar 19;13:99-101. Epub 2018 Dec 19.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Purpose: If not recognized and treated promptly, nontraumatic orbital subperiosteal hemorrhage (NTSOH) can have serious sequelae including compressive optic neuropathy and permanent vision loss. The following case establishes erotic asphyxiation as a cause of NTSOH.

Observations: A 29 year-old patient presented with diplopia and periorbital edema and ecchymosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183021
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http://dx.doi.org/10.1016/j.ajoc.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305683PMC
March 2019
5 Reads

Orbital apex venous cavernous malformation with optic neuropathy: treatment with multisession gamma knife radiosurgery.

Br J Ophthalmol 2019 10 5;103(10):1453-1459. Epub 2019 Jan 5.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Purpose: To evaluate the efficacy and safety of multisession gamma knife radiosurgery (GKRS) for orbital apex venous cavernous malformation causing optic neuropathy.

Methods: Retrospective cohort study in a single tertiary institution from January 2007 to December 2016 on patients who underwent multisession GKRS for orbital apex venous cavernous malformations causing optic neuropathy.

Results: There were 12 patients included in our study. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
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http://dx.doi.org/10.1136/bjophthalmol-2018-312893DOI Listing
October 2019
18 Reads

Navigation-assisted, endonasal, endoscopic optic nerve decompression for the treatment of nontraumatic optic neuropathy.

J Craniomaxillofac Surg 2019 Feb 13;47(2):328-333. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. Electronic address:

Background: Many authors have reported on therapeutic strategies for traumatic optic neuropathy and their experience with endonasal endoscopic optic nerve decompression for traumatic optic neuropathy. However, to our knowledge, few have described the therapeutic strategies for nontraumatic optic neuropathy and navigation-assisted endoscopic optic nerve decompression as a treatment for nontraumatic, compressive optic neuropathy. The aim of this study was to examine the advantages in treating nontraumatic optic neuropathy with the minimally invasive, image-guided, navigation-assisted, endonasal endoscopic optic nerve decompression. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.12.009DOI Listing
February 2019
16 Reads