497 results match your criteria Optic Neuropathy Compressive


Yield of screening blood work and MRI of the brain and orbits in the work-up of unilateral chronic optic neuropathy.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

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http://dx.doi.org/10.1038/s41433-018-0326-6DOI Listing
February 2019

[Etiology and diagnostics of compressive optic neuropathies].

Vestn Oftalmol 2018 ;134(6):72-82

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Purpose: To determine the causes and study the clinical manifestations of compressive optic neuropathy (CON).

Material And Methods: The study included 24 male and 36 female patients with CON (in total 60 patients, 97 eyes). All patients underwent standard ophthalmic examination, as well as computer perimetry, magnetic resonance imaging (MRI), and/or computed tomography (CT) of the brain and orbit and magnetic resonance angiography (MRA). Read More

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http://dx.doi.org/10.17116/oftalma201813406172DOI Listing
January 2018
1 Read

Methotrexate as an Adjuvant in Severe Thyroid Eye Disease: Does It Really Work as a Steroid-Sparing Agent?

Ophthalmic Plast Reconstr Surg 2019 Jan 7. Epub 2019 Jan 7.

Oculoplastic Department, Singapore National Eye Centre, Singapore.

Purpose: To compare the efficacy and safety of adjunctive oral methotrexate with intravenous pulsed methylprednisolone against methylprednisolone alone in the treatment of severe thyroid eye disease.

Methods: Retrospective review of clinical data of patients with severe sight-threatening thyroid eye disease with compressive optic neuropathy treated with methylprednisolone with and without methotrexate. Eye disease outcome measures (e. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001279DOI Listing
January 2019

Erotic asphyxiation: May have you seeing double.

Am J Ophthalmol Case Rep 2019 Mar 19;13:99-101. Epub 2018 Dec 19.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Purpose: If not recognized and treated promptly, nontraumatic orbital subperiosteal hemorrhage (NTSOH) can have serious sequelae including compressive optic neuropathy and permanent vision loss. The following case establishes erotic asphyxiation as a cause of NTSOH.

Observations: A 29 year-old patient presented with diplopia and periorbital edema and ecchymosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183021
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http://dx.doi.org/10.1016/j.ajoc.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305683PMC
March 2019
1 Read

Orbital apex venous cavernous malformation with optic neuropathy: treatment with multisession gamma knife radiosurgery.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Purpose: To evaluate the efficacy and safety of multisession gamma knife radiosurgery (GKRS) for orbital apex venous cavernous malformation causing optic neuropathy.

Methods: Retrospective cohort study in a single tertiary institution from January 2007 to December 2016 on patients who underwent multisession GKRS for orbital apex venous cavernous malformations causing optic neuropathy.

Results: There were 12 patients included in our study. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
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http://dx.doi.org/10.1136/bjophthalmol-2018-312893DOI Listing
January 2019
6 Reads

Navigation-assisted, endonasal, endoscopic optic nerve decompression for the treatment of nontraumatic optic neuropathy.

J Craniomaxillofac Surg 2019 Feb 13;47(2):328-333. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. Electronic address:

Background: Many authors have reported on therapeutic strategies for traumatic optic neuropathy and their experience with endonasal endoscopic optic nerve decompression for traumatic optic neuropathy. However, to our knowledge, few have described the therapeutic strategies for nontraumatic optic neuropathy and navigation-assisted endoscopic optic nerve decompression as a treatment for nontraumatic, compressive optic neuropathy. The aim of this study was to examine the advantages in treating nontraumatic optic neuropathy with the minimally invasive, image-guided, navigation-assisted, endonasal endoscopic optic nerve decompression. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.12.009DOI Listing
February 2019
1 Read

Loss of horizontal macular ganglion cell complex asymmetry: an optical coherence tomography indicator of chiasmal compression.

BMJ Open Ophthalmol 2018 25;3(1):e000195. Epub 2018 Oct 25.

Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway.

Objective: To estimate the macular ganglion cell complex (GCC) asymmetry in patients with suprasellar tumours, to compare its diagnostic performance to the nasal GCC thickness and visual field (VF) and to investigate how the parameters correlate with magnetic resonance imaging (MRI) findings.

Methods And Analysis: Cross-sectional study of patients with suprasellar tumours affecting the optic chiasm. Macular optical coherence tomography (OCT) scans were evaluated for nasal GCC sector thinning and loss of normal GCC asymmetry between corresponding nasal-temporal sectors. Read More

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
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http://dx.doi.org/10.1136/bmjophth-2018-000195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243475PMC
October 2018
11 Reads

Compressive optic neuropathy secondary to Ewing sarcoma in the paranasal sinus: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13027

Department of Ophthalmology.

Rationale: Ewing sarcoma localized in the paranasal sinuses, compressing the optic nerve, is very rare, with no prior case reports PATIENT CONCERNS:: A 68-year-old woman presented with decreased visual acuity in her left eye and paresthesia of the left face. Brain magnetic resonance imaging showed heterogeneously enhancing mass in the left paranasal sinuses with adjacent bone destruction, extending to the extraocular muscles and optic nerve of the left orbit. A biopsy of the nasal cavity confirmed Ewing sarcoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221559PMC
November 2018
5 Reads

The role of early office-based needle aspiration in the management of subperiosteal hematoma.

Orbit 2018 Oct 18:1-3. Epub 2018 Oct 18.

a Eye Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.

Subperiosteal hematoma of the orbit is a rare complication that may occur in different situations. The most common cause is blunt trauma to the head region. The victims are usually young boys and the common site is usually orbital roof. Read More

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http://dx.doi.org/10.1080/01676830.2018.1528618DOI Listing
October 2018
1 Read

Age-Related Changes in the Clinical Phenotype of Compressive Optic Neuropathy in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Sep 14. Epub 2018 Sep 14.

Ophthalmic Plastic and Reconstructive and Orbital Surgery Division, Department of Ophthalmology, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York, U.S.A.

Purpose: This study compares the age-related clinical features of thyroid eye disease-compressive optic neuropathy (TED-CON) to those with noncompressive disease (TED-NC).

Methods: A retrospective case series review of 165 orbits from 121 patients with TED-CON were compared with an age- and gender-matched cohort of 88 orbits from 44 patients with TED-NC with institutional review board approval. Clinical features including exophthalmos, dyschromatopsia, restricted ocular motility, visual acuity, and mean deviation on 24-2 Humphrey Visual Field were compared in 5 age groups. Read More

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http://Insights.ovid.com/crossref?an=00002341-900000000-9842
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http://dx.doi.org/10.1097/IOP.0000000000001213DOI Listing
September 2018
8 Reads

Rhinogenous optic neuritis with full recovery of vision - The role of endoscopic optic nerve decompression and a review of literature.

Am J Otolaryngol 2018 Nov - Dec;39(6):791-795. Epub 2018 Aug 29.

Department of Otorhinolaryngology-Head and Neck Surgery, Changi General Hospital, Singapore, 2 Simei Street 3, Singapore 529889, Singapore. Electronic address:

Background: Optic neuritis resulting from paranasal sinusitis is an infrequently described but clinically important and treatable entity. The role of optic nerve decompression has been well established in atraumatic optic neuropathies which are compressive in origin. However, its role in optic neuritis and other infective or inflammatory processes is lacking, and the role for early surgical intervention remains controversial. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.08.008DOI Listing
February 2019

Bilateral endoscopic optic nerve decompression in an infant with osteopetrosis.

J AAPOS 2018 Aug 29. Epub 2018 Aug 29.

Department of Ophthalmology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.

Osteopetrosis is a rare disorder of bone remodeling characterized by defective resorption leading to excessive skeletal mass including optic canal. Compression of the optic nerve from the narrowed optic canal is the most common cause of vision loss in children with osteopetrosis. We report the case of a 6-month old girl with osteopetrosis who underwent bilateral optic canal decompression via endoscopic transcaruncular approach for progressive deterioration of visual function secondary to compressive optic neuropathy from narrowed optic canals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10918531183050
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http://dx.doi.org/10.1016/j.jaapos.2018.05.012DOI Listing
August 2018
12 Reads

Unilateral transient cyanopsia as an early symptom of compressive optic neuropathy.

Neurol Sci 2018 Dec 24;39(12):2221-2222. Epub 2018 Aug 24.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, South Korea.

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http://dx.doi.org/10.1007/s10072-018-3535-7DOI Listing
December 2018
2 Reads

Association of Risk of Obstructive Sleep Apnea With Thyroid Eye Disease: Compressive Optic Neuropathy.

Ophthalmic Plast Reconstr Surg 2018 Aug 21. Epub 2018 Aug 21.

Columbia University Medical Center, New York, New York, U.S.A.

Purpose: To evaluate the association of risk of obstructive sleep apnea (OSA) and thyroid eye disease-compressive optic neuropathy (TED-CON).

Methods: The authors performed a retrospective observational study. All TED patients evaluated by the principal investigator over the past 5 years were screened with the snoring tired observed pressure (STOP)-Bang questionnaire to assess their risk for OSA. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001211DOI Listing
August 2018
1 Read

Orbital Emphysema: A Case Report and Comprehensive Review of the Literature.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):1-6

Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.

Purpose: The objective of this study was to report a case of persistent and likely self-induced orbital emphysema (OE) following functional endoscopic sinus surgery with dislodgement of a previously placed orbital floor implant and to review the literature surrounding etiologies, pathophysiology, and management of OE.

Methods: Case report and review of the literature.

Results And Discussion: While blunt trauma resulting in disruption of the medial orbital wall is the most common cause of OE, there are an additional 25 underlying etiologies reported in the current literature. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001216DOI Listing
August 2018
18 Reads

Predominant Contribution of Superior Rectus-Levator Complex Enlargement to Optic Neuropathy and Inferior Visual Field Defects in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Aug 17. Epub 2018 Aug 17.

Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, U.S.A.

Purpose: To compare extraocular muscle volumes in thyroid eye disease patients with and without compressive optic neuropathy.

Methods: A retrospective review of 44 orbital CT scans (28 orbits without compressive disease and 16 orbits with compressive optic neuropathy) was conducted. The extraocular muscle volumes, summated soft tissue volumes, and optic nerve volumes were calculated at a section in the posterior 1/3 of the orbit. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001224DOI Listing
August 2018
1 Read

Radiation-Induced Optic Neuropathy: Clinical and Imaging Profile of Twelve Patients.

J Neuroophthalmol 2018 Aug 15. Epub 2018 Aug 15.

Departments of Ophthalmology and Visual Sciences (ELA, JDT), Radiology (Neuroradiology) (EAL), and Neurology (JDT), Kellogg Eye Center, Ann Arbor, Michigan.

Background: Radiation-induced optic neuropathy (RON) is a form of delayed radionecrosis of the anterior visual pathways, which develops within months to years after external cranial irradiation and causes severe and irreversible vision loss. Small series reports have adequately documented its clinical features, but imaging characteristics have been less completely described.

Methods: We accrued cases from the University of Michigan Neuro-Ophthalmology Clinic files and from cases coded as "radiation optic neuropathy" at the University of Michigan Medical Center between 1994 and 2017. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000670DOI Listing

Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression.

Pituitary 2018 Oct;21(5):515-523

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

Purpose: To report patients with sellar tumors and chiasmal compression with normal visual fields, who demonstrate damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) on optical coherence tomography (OCT).

Methods: Seven patients with sellar tumors causing mass effect on the optic chiasm without definite visual field defect, but abnormal GCC are described. GCC/RNFL analyses using Cirrus-OCT were classified into centiles based on the manufacturer's reference range. Read More

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http://dx.doi.org/10.1007/s11102-018-0906-2DOI Listing
October 2018
2 Reads

The Case of IgG4-related Ophthalmic Disease Accompanied by Compressive Optic Neuropathy.

Neuroophthalmology 2018 Aug 25;42(4):246-250. Epub 2017 Oct 25.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

A 76-year-old woman was diagnosed with thyroid-associated orbitopathy (TAO) associated with hypothyroidism at another clinic. Magnetic resonance imaging showed enlargements of the extraocular muscles. Because her best-corrected visual acuity (BCVA) was 0. Read More

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http://dx.doi.org/10.1080/01658107.2017.1389962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056210PMC
August 2018
1 Read

Incidence and Mimickers of Acute Idiopathic Optic Neuritis: Analysis of 291 Consecutive Patients from Southern Finland.

Ophthalmic Epidemiol 2018 Oct - Dec;25(5-6):386-391. Epub 2018 Jul 24.

b Neurology , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

Purpose: To estimate the population-based incidence of acute idiopathic optic neuritis (ON) and analyse its differential diagnosis in patients referred with symptoms suggestive of ON.

Methods: Patients with suspected ON referred to the Helsinki University Hospital, serving a population of 1.5 million in Southern Finland, were reviewed between 1st May 2008 and 14th April 2012. Read More

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http://dx.doi.org/10.1080/09286586.2018.1500614DOI Listing

Modeling Neurodegeneration in Patients with Visual Pathway Tumors by Retinal Optical Coherence Tomography.

World Neurosurg 2018 Sep 15;117:e341-e348. Epub 2018 Jun 15.

Department of Neurosurgery, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania; Clinic of Neurosurgery, Emergency County Hospital Cluj, Cluj-Napoca, Romania.

Objective: Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technique that was suggested to be a powerful biomarker of neurodegeneration. The objective of our study is to assess the pattern of retinal OCT changes in patients with visual pathway tumors.

Methods: A prospective clinical study was conducted and patients with single cerebral tumors with potential of compression on the visual pathway were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183124
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http://dx.doi.org/10.1016/j.wneu.2018.06.032DOI Listing
September 2018
7 Reads

The Columbia Thyroid Eye Disease-Compressive Optic Neuropathy Diagnostic Formula.

Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S68-S71

Ophthalmic Plastic and Reconstructive, and Orbital Surgery Division, Department of Ophthalmology, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York.

Purpose: Diagnosing thyroid eye disease-compressive optic neuropathy (TED-CON) is challenging, particularly in cases lacking a relative afferent pupillary defect. Large case series of TED-CON patients and accessible diagnostic tools are lacking in the current literature. This study aims to create a mathematical formula that accurately predicts the presence or absence of CON based on the most salient clinical measures of optic neuropathy. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001128DOI Listing
August 2018
8 Reads

Pain in optic neuropathies.

Neurol Sci 2018 Jun;39(Suppl 1):25-31

Neuro-ophthalmology and Ocular Electrophysiology Center, Department of Ophthalmology, Scientific Institute Capitanio Hospital, Istituto Auxologico Italiano Foundation, Via Mercalli, 28, 20122, Milan, Italy.

Pain occurs with optic neuropathies associated with inflammatory central nervous system diseases (MS and NMO), idiopathic intracranial hypertension and spontaneous hypotension, giant cell arteritis, immunomediated systemic diseases, compressive lesions, or infective disorders. Pain can precede the onset of visual loss in acute optic neuritis, it can be irradiated to the orbital region in giant cell arteritis and parasellar compressive optic neuropathies, or it may be located to the back of the eye with posterior scleritis. History of symptoms together with complete neuro-ophthalmological examination must guide the differential diagnosis and neuroimaging. Read More

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http://dx.doi.org/10.1007/s10072-018-3334-1DOI Listing
June 2018
3 Reads

Greater Proptosis Is Not Associated With Improved Compressive Optic Neuropathy in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S72-S74

Harkness Eye Institute, Columbia University Medical Center, New York, U.S.A.

Purpose: Despite the paucity of supporting data, it has generally been held that proptosis in thyroid eye disease (TED) may provide relative protection from compressive optic neuropathy (CON) by producing spontaneous decompression. The objective of this study was to investigate this phenomenon in patients with bilateral TED-CON.

Methods: We retrospectively reviewed the charts of 67 patients (134 orbits) with bilateral TED-CON at Columbia-Presbyterian Medical Center. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001134DOI Listing
August 2018
4 Reads

The role of Optical Coherence Tomography in optic neuropathies.

Rom J Ophthalmol 2018 Jan-Mar;62(1):3-14

Department of Ophthalmology, "N. Oblu" Clinical Emergency Hospital, Iaşi, Romania.

Optical neuropathies are neuro-ophthalmologic disorders, the main symptoms of which are the decrease of visual acuity and the alteration of the color vision. Optical coherence tomography has been one of the most important innovations in ophthalmology, which offered the possibility to analyze specific structures of the retina. Optical coherence tomography performs in vivo, real-time, noncontact scanning and provides cross-sectional and volumetric images with a resolution approaching that of histology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959022PMC
July 2018
2 Reads

Optic nerve compression as a late complication of a hydrogel explant with silicone encircling band.

Am J Ophthalmol Case Rep 2018 Jun 19;10:293-295. Epub 2018 Apr 19.

Department of Ophthalmology, Radboud University Medical Center Nijmegen, Philips van Leydenlaan 15, 6525 EX Nijmegen, The Netherlands.

Purpose: To present a complication of compressive optic neuropathy caused by a swollen hydrogel explant and posteriorly displaced silicone encircling band.

Observations: A 72-year-old female patient presented with progressive visual loss and a tilted optic disc. Her medical history included a retinal detachment in 1993 that was treated with a hydrogel explant under a solid silicone encircling band. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956580PMC

Radiotherapy for Active Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S98-S104

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York, U.S.A.

Purpose: To critically review the published literature on orbital radiotherapy as a treatment modality for thyroid eye disease (TED).

Methods: A systematic review and analysis of the relevant published literature was performed.

Results: Thyroid eye disease is an autoimmune condition that is amenable to treatments that modulate the immune response, including orbital radiotherapy (ORT). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001074DOI Listing

Olfactory Neuroblastoma: A Rare Cause of External Ophthalmoplegia, Proptosis and Compressive Optic Neuropathy.

Turk J Ophthalmol 2018 Apr 25;48(2):92-94. Epub 2018 Apr 25.

University of Health Sciences, İzmir Bozyaka Training and Research Hospital, Ophthalmology Clinic, İzmir, Turkey.

Olfactory neuroblastoma (ONB), which is a neuroectodermal tumor of the nasal cavity, is a rare and locally aggressive malignancy that may invade the orbit via local destruction. In this study, we report a patient with proptosis, external ophthalmoplegia, and compressive optic neuropathy caused by ONB. A detailed clinical examination including ocular imaging and histopathological studies were performed. Read More

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http://dx.doi.org/10.4274/tjo.81568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938484PMC
April 2018
14 Reads

[Idiopathic orbital inflammatory syndrome: Report of 24 cases].

J Fr Ophtalmol 2018 Apr 21;41(4):333-342. Epub 2018 Apr 21.

Centre hospitalo-universitaire Fattouma Bourguiba, Monastir, Tunisie.

Background: Idiopathic orbital inflammatory syndrome (IOIS) is an inflammatory condition of unknown etiology. The inflammation may affect all the structures within the orbit (anterior, diffuse, apical, myositic, dacryoadenitis) and corresponds to uniquely orbital inflammation without an identifiable local cause or systemic disease. The goal of this study is to describe the clinical and radiographic characteristics of IOIS and discuss the role of orbital biopsy in this condition. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.09.013DOI Listing
April 2018
22 Reads

An atypical case of neurosarcoidosis presenting with neovascular glaucoma.

J Ophthalmic Inflamm Infect 2018 Apr 18;8(1). Epub 2018 Apr 18.

Department of Ophthalmology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium.

Background: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative.

Findings: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Read More

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https://joii-journal.springeropen.com/articles/10.1186/s1234
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http://dx.doi.org/10.1186/s12348-018-0149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906415PMC
April 2018
4 Reads

Prevalence of Ocular Hypertension and Glaucoma as Well as Associated Factors in Graves' Orbitopathy.

J Glaucoma 2018 May;27(5):464-469

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul.

Purpose: The purpose of this study was to determine the prevalence of ocular hypertension (OHT) and open-angle glaucoma (OAG) in patients with Graves' orbitopathy (GO) and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG.

Methods: A cross-sectional analytic study was conducted among a total of 1128 patients with GO. A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography. Read More

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http://dx.doi.org/10.1097/IJG.0000000000000942DOI Listing
May 2018
3 Reads

Orbital Radiotherapy Combined With Corticosteroid Treatment for Thyroid Eye Disease-Compressive Optic Neuropathy.

Ophthalmic Plast Reconstr Surg 2018 Mar/Apr;34(2):172-177

Department of Ophthalmology, Columbia University, New York, New York.

Purpose: To evaluate the effectiveness of orbital radiotherapy (ORT) in the treatment of thyroid eye disease (TED)-compressive optic neuropathy.

Methods: A retrospective review of patients with corticosteroid-responsive compressive optic neuropathy due to TED treated with ORT. Study was conducted in compliance with Health Insurance Portability and Accountability Act. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001003DOI Listing
July 2018
4 Reads

Orbital Apex Metastasis from Adenoid Cystic Carcinoma: Acute Loss of Vision and Subsequent Recovery with the Radiation.

Cureus 2017 Nov 22;9(11):e1869. Epub 2017 Nov 22.

Department of Radiation Oncology, St. Mary's Medical Center.

Orbital apex metastasis from adenoid cystic carcinoma (ACC) is rare. We present a patient with known metastatic ACC presented with a rapidly declining vision with visual acuity oculus dexter (OD) equal to counting fingers at two feet. On imaging, she was found to have a right orbital apex tumor causing compressive optic neuropathy. Read More

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http://dx.doi.org/10.7759/cureus.1869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777629PMC
November 2017
2 Reads

IgG4-related cerebral pseudotumor with perineural spreading along branches of the trigeminal nerves causing compressive optic neuropathy: A case report.

Medicine (Baltimore) 2017 Nov;96(47):e8709

Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan.

Rationale: Immunoglobulin G4-related disease (IgG4-RD) is characterized by tumor-like lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has been described in a variety of organ systems; however, it rarely involves the central nervous system.

Patient Concerns: A 17-year-old woman visited our clinic with a complaint of blurred vision for the past 5 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000008709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708958PMC
November 2017
8 Reads

Bilateral Compressive Optic Neuropathy from Renal Osteodystrophy Caused by Branchio-oto-renal Syndrome Stabilised After Parathyroidectomy.

Neuroophthalmology 2017 Dec 10;41(6):321-325. Epub 2017 May 10.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Renal osteodystrophy can cause calvarial hypertrophy and narrowing of the neural canals and foramina. Compressive optic neuropathy is extremely rare in renal osteodystrophy and was reported once only. The authors report bilateral, simultaneous compressive optic neuropathy secondary to renal osteodystrophy with features of uremic leontiasis ossea in chronic renal failure caused by branchio-oto-renal syndrome. Read More

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http://dx.doi.org/10.1080/01658107.2017.1315145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764064PMC
December 2017
16 Reads

Visual prognosis in compressive optic neuropathy secondary to sphenoid sinus mucocele: A systematic review.

Orbit 2018 Aug 5;37(4):280-286. Epub 2018 Jan 5.

a Department of Ophthalmology and Visual Science , Yale University School of Medicine , New Haven , Connecticut , USA.

Sphenoid sinus mucoceles (SSMs) are rare, benign lesions that can expand, often presenting with ocular symptoms-decreased vision, diplopia, visual field defects, proptosis, and external ophthalmoplegia. Reported cases are few, visual compromise varies, and factors affecting visual prognosis are poorly characterized. We investigate whether prompt surgical intervention (within 2 weeks of visual symptom onset) affects best-corrected visual acuity (BCVA) regained in patients with vision loss secondary to compressive SSM. Read More

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http://dx.doi.org/10.1080/01676830.2017.1423087DOI Listing
August 2018
5 Reads

Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey.

Int Ophthalmol 2017 Dec 19. Epub 2017 Dec 19.

Department of Neurology, Ege University Medical Faculty, Izmir, Turkey.

Purpose: To analyze the demographic patterns, clinical characteristics, and treatment protocols of optic neuropathies.

Materials And Methods: The hospital data of patients with optic neuropathy admitted to the Department of Neuro-ophthalmology in a tertiary referral center in Turkey between January 2010 to January 2017 were retrospectively analyzed. Demographic patterns, clinical features, treatment protocols, and the natural disease courses were assessed. Read More

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http://dx.doi.org/10.1007/s10792-017-0799-5DOI Listing
December 2017
21 Reads

Development of a Platform for Studying 3D Astrocyte Mechanobiology: Compression of Astrocytes in Collagen Gels.

Ann Biomed Eng 2018 Feb 27;46(2):365-374. Epub 2017 Nov 27.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Dr. NW, Atlanta, GA, 30332, USA.

Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, proliferative phenotype, which has been implicated in the progression of glaucomatous vision loss. Read More

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http://dx.doi.org/10.1007/s10439-017-1967-5DOI Listing
February 2018
36 Reads

Neuroimaging diagnostic and monitoring approaches in ophthalmology.

Curr Opin Neurol 2018 Feb;31(1):66-73

Neuro-ophthalmology Service, Massachusetts Eye & Ear, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: We review new applications of optical coherence tomography (OCT) technology in neuro-ophthalmology. We also describe new technologies for visualizing the extracranial vessels in the diagnosis of giant cell arteritis (GCA).

Recent Findings: Newer OCT modalities are expanding the evaluation of the optic disc, and are being applied to a number of neurologic conditions such as demyelinating and neurodegenerative disease. Read More

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http://Insights.ovid.com/crossref?an=00019052-900000000-9917
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http://dx.doi.org/10.1097/WCO.0000000000000518DOI Listing
February 2018
7 Reads

Modified lateral orbital wall decompression in Graves' orbitopathy using computer-assisted planning.

Int J Oral Maxillofac Surg 2018 Feb 31;47(2):167-174. Epub 2017 Oct 31.

Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.

Graves' orbitopathy, a condition seen in the autoimmune syndrome Graves' disease, affects the fatty tissue and muscles inside the orbit. Graves' orbitopathy is associated with increasing exophthalmos and sometimes leads to compressive dysthyroid optic neuropathy, resulting in progressive vision loss. Dysthyroid compressive optic neuropathy, functional problems, and cosmetic problems are the main indications for surgical decompression of the orbit, especially if conservative treatment has not led to a reduction in symptoms. Read More

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http://dx.doi.org/10.1016/j.ijom.2017.10.009DOI Listing
February 2018
1 Read

IgG4-related orbital disease masquerading as thyroid eye disease, vice versa, or both?

Orbit 2018 Aug 20;37(4):239-242. Epub 2017 Oct 20.

b Department of Ophthalmology, Ophthalmic Plastic, Reconstructive, and Orbital Surgery Division , Columbia University Medical Center , New York , NY , USA.

A 40 year-old male presented after one year of unilateral, progressive, steroid-responsive, orbital inflammatory disease causing proptosis, extraocular muscle (EOM) restriction, and compressive optic neuropathy. The development of anti-thyroidal antibodies prompted the diagnosis of thyroid eye disease (TED); however, the prolonged active phase, remarkable reversibility of ophthalmic features with high-dose corticosteroids, unilaterally of disease, uncharacteristic EOM involvement (including both obliques), and the absence of autoimmune thyroid disease provoked consideration of alternative diagnoses. Inferior oblique biopsy stained positive for IgG4 with histologic features atypical of TED. Read More

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http://dx.doi.org/10.1080/01676830.2017.1383478DOI Listing
August 2018
8 Reads

Optical Coherence Tomography in the Management of Skull Base Fibrous Dysplasia with Optic Nerve Involvement.

World Neurosurg 2018 Jan 13;109:e546-e553. Epub 2017 Oct 13.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Fibrous dysplasia (FD) of the skull base can manifest with optic nerve compression. As most patients initially do not experience vision loss, controversy exists whether to proceed with prophylactic surgical decompression or elect for conservative observation. Optical coherence tomography (OCT), a physiologic imaging modality widely used to assess the condition of the retinal nerve fiber layer (RNFL), has been useful in monitoring compressive tumors on the optic nerve. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.10.018DOI Listing
January 2018
13 Reads

Role of fractionated radiotherapy in patients with hemangioma of the cavernous sinus.

Radiat Oncol J 2017 Sep 29;35(3):268-273. Epub 2017 Sep 29.

Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: We performed this retrospective study to investigate the outcomes of patients with hemangioma of the cavernous sinus after fractionated radiotherapy.

Materials And Methods: We analyzed 10 patients with hemangioma of the cavernous sinus who were treated with conventional radiotherapy between January 2000 and December 2016. The median patient age was 54 years (range, 31-65 years), and 8 patients (80. Read More

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http://dx.doi.org/10.3857/roj.2017.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647752PMC
September 2017
7 Reads

Ganglion cell layer complex measurements in compressive optic neuropathy.

Curr Opin Ophthalmol 2017 Nov;28(6):573-578

New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: Neuroophthalmologists and neurosurgeons are often asked by their patients what their visual prognosis will be after decompression of an optic chiasm lesion. Previous methods have been studied but have not provided consistent guidance. However, a recent algorithm which allows for retinal ganglion cell analysis from optical coherence tomography (OCT) may be more helpful. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000428DOI Listing
November 2017
20 Reads

Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation.

Invest Ophthalmol Vis Sci 2017 08;58(10):4235-4246

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

Purpose: The purpose of this study was to quantify the biomechanical response of human posterior ocular tissues from donors of various racioethnic groups to better understand how differences in these properties may play a role in the racioethnic health disparities known to exist in glaucoma.

Methods: Sequential digital image correlation (S-DIC) was used to measure the pressure-induced surface deformations of 23 normal human posterior poles from three racioethnic groups: African descent (AD), European descent (ED), and Hispanic ethnicity (HIS). Regional in-plane principal strains were compared across three zones: the optic nerve stump (ONS), the peripapillary (PP) sclera, and non-PP sclera. Read More

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http://dx.doi.org/10.1167/iovs.17-22141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574446PMC
August 2017
6 Reads

Optic neuropathy after anterior communicating artery aneurysm clipping: 3 cases and techniques to address a correctable pitfall.

J Neurosurg 2018 Jun 25;128(6):1808-1812. Epub 2017 Aug 25.

2Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan.

Brain shifts following microsurgical clip ligation of anterior communicating artery (ACoA) aneurysms can lead to mechanical compression of the optic nerve by the clip. Recognition of this condition and early repositioning of clips can lead to reversal of vision loss. The authors identified 3 patients with an afferent pupillary defect following microsurgical clipping of ACoA aneurysms. Read More

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http://dx.doi.org/10.3171/2017.2.JNS162654DOI Listing
June 2018
34 Reads

Gorham-Stout Disease Presenting as Acute Unilateral Proptosis.

J Neuroophthalmol 2018 Mar;38(1):70-74

Division of Neuro-Ophthalmology, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.

Gorham-Stout disease (GSD) is a rare angiomatous disorder characterized by osteolysis. We report the case of a 66-year-old woman who developed sudden left eye proptosis and facial pain. Neuroimaging demonstrated a destructive mass involving the roof and lateral wall of the left orbit with adjacent abnormal orbital soft tissue. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000569DOI Listing
March 2018
24 Reads

Orbital apex cyst: a rare cause of compressive optic neuropathy post-functional endoscopic sinus surgery.

Int Med Case Rep J 2017 28;10:263-269. Epub 2017 Jul 28.

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

There are various causes that can lead to compressive optic neuropathy. We present here orbital apex cyst as an unusual cause of compressive optic neuropathy in a 49-year-old male. He presented with 2 weeks painless loss of vision in the left eye with left-sided headache. Read More

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http://dx.doi.org/10.2147/IMCRJ.S124524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546777PMC
July 2017
8 Reads

Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management.

Expert Rev Ophthalmol 2017 27;12(2):111-121. Epub 2017 Jan 27.

Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.

Introduction: Dysthyroid optic neuropathy (DON) is a severe manifestation of thyroid eye disease (TED) that can result in permanent vision loss. Management is complex, multidisciplinary, and involves medical and/or surgical therapies. This review describes current concepts in the epidemiology, pathophysiology, diagnosis, and treatment of DON. Read More

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http://dx.doi.org/10.1080/17469899.2017.1276444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535799PMC
January 2017
8 Reads