644 results match your criteria Optic Neuropathy Compressive


Predictive Modeling of New-Onset Postoperative Diplopia Following Orbital Decompression for Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2022 May 13. Epub 2022 May 13.

Division of Oculofacial Plastic and Reconstructive Surgery, UC San Diego Department of Ophthalmology, Shiley Eye Institute, La Jolla, California.

Purpose: To identify risk factors for the development of new-onset, postoperative diplopia following orbital decompression surgery based on patient demographics, clinical exam characteristics, radiographic parameters, and surgical techniques.

Methods: We conducted a multi-center retrospective chart review of patients who underwent orbital decompression for thyroid eye disease (TED). Patient demographics, including age, gender, smoking history, preoperative exophthalmometry, clinical activity score (CAS), use of peribulbar and/or systemic steroids, and type of orbital decompression were reviewed. Read More

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A Paradigm Shift in the Management of Thyroid Eye Disease How Teprotumumab Has Changed the Therapeutic Interface.

J Neuroophthalmol 2022 Mar;42(1):26-34

Department of ophthalmology (SU), the Jules Stein Eye Institute, University of California, Los Angeles, California; Byers Eye Institute at Stanford University School of Medicine (ALK, KC), Palo Alto, California; Cedars Sinai Medical Center (RD), Los Angeles, California; Central Valley Eye Medical Group (KC), Stockton, California.

Background: Teprotumumab, a monoclonal antibody that blocks the insulin-like growth factor-1 receptor, has recently been approved by the US Food and Drug Administration (FDA) for the treatment of thyroid eye disease (TED). Since its approval, aside from data on the safety and clinical efficacy of teprotumumab from Phase-2 and Phase-3 trials, only a handful of reports have been published regarding its use in the wider population. In this review, we briefly describe the mechanism of action of teprotumumab and review the literature to provide an overview of published clinical experience. Read More

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Combined endoscopic endonasal and transorbital multiportal approach for complex skull base lesions involving multiple compartments.

Acta Neurochir (Wien) 2022 Apr 29. Epub 2022 Apr 29.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Purpose: This study defines the specific areas that connect the surgical corridors of the endoscopic endonasal (EEA) and transorbital approach (TOA) to identify adequate clinical applications and perspectives of this combined multiportal approach.

Methods: Consecutive patients who underwent combined EEA and TOA procedures for various pathologies involving multiple compartments of the skull base were enrolled.

Results: A total of eight patients (2 chondrosarcomas, 2 meningiomas, 2 schwannomas, 1 glioma, and 1 traumatic optic neuropathy) were included between August 2016 and April 2021. Read More

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Structural and functional differentiation between compressive and glaucomatous optic neuropathy.

Sci Rep 2022 Apr 26;12(1):6795. Epub 2022 Apr 26.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.

Clinical diagnoses of slow, progressive, painless visual losses with various degrees of visual field (VF) losses and disc atrophy are often confused between suprasellar compressive optic neuropathy (CON) and open-angle glaucomatous optic neuropathy (GON). We plotted the thickness of the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) against the mean deviation (MD) of the VF of 34 eyes of CON at diagnosis, 30 eyes of CON after therapy, 29 eyes of GON, and 60 eyes of healthy controls in a cross-sectional investigation. At diagnosis, a disproportionally early pattern of structural thinning compared with the corresponding VF losses was unique to CON. Read More

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Isolated Compressive Optic Neuropathy Due to Cavernous Carotid Aneurysms: A 2-Patient Case Report.

J Neuroophthalmol 2022 Apr 19. Epub 2022 Apr 19.

Departments of Ophthalmology (WC, CNF, PSS), Neurology (PSS), and Neurosurgery (PSS), University of Colorado School of Medicine and Sue Anschutz-Rodgers UCHealth Eye Center, Aurora, Colorado; and Division of Ophthalmology (PSS), Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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Comparative Evaluation of Two SD-OCT Macular Parameters (GCC, GCL) and RNFL in Chiasmal Compression.

Eye Brain 2022 5;14:35-48. Epub 2022 Mar 5.

Department of Ophthalmology, Robert Debré Hospital, Reims, France.

Purpose: To evaluate the relationship between different macular thickness parameters analyzed by SD-OCT and the central visual field (VF) evaluated with automated kinetic perimetry in a cohort of patients with pituitary tumors.

Methods: Data from patients with pituitary adenoma treated at Reims University Hospital between October 1st, 2017, and May 31st, 2018 were collected. All patients underwent an automated kinetic perimetry and a SD-OCT to map the ganglion cell complex (GCC), the ganglion cell layer (GCL) thickness and the retinal nerve fiber layer (RNFL) using devices from two different manufacturers. Read More

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Rare early presentation of bilateral compressive optic neuropathy with complete vision loss from nasopharyngeal carcinoma.

BMJ Case Rep 2022 Mar 1;15(3). Epub 2022 Mar 1.

Department of Neurology, National Neuroscience Institute, Singapore.

Nasopharyngeal carcinoma is very rarely associated with bilateral vision loss, and only in advanced disease. We report a case of bilateral severe compressive optic neuropathy as a first presentation from massive nasopharyngeal carcinoma with poor visual outcome despite corticosteroid, chemotherapy and radiotherapy. Red flag symptoms and signs of mass lesions in the posterior nasal space should be investigated and treated promptly to prevent devastating visual and prognostic consequences. Read More

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A Novel Mutation in a Gene Causes Sclerosteosis in a Family of Mediterranean Origin.

Medicina (Kaunas) 2022 Jan 28;58(2). Epub 2022 Jan 28.

Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh 11437, Saudi Arabia.

: Sclerostin is an gene product that inhibits osteoblast activity and prevents excessive bone formation by antagonizing the Wnt signaling pathway. Sclerosteosis has been linked to loss of function mutations in the gene. It is a rare autosomal recessive disorder characterized by craniotubular hyperostosis and can lead to fatal cerebellar herniation. Read More

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January 2022

Clinical profile and retinal nerve fibre layer thickness of optic disc oedema patients at a tertiary care institute in North India.

Ther Adv Ophthalmol 2022 Jan-Dec;14:25158414211072634. Epub 2022 Feb 14.

Department of Ophthalmology, All India Institute of Medical Sciences Rishikesh, Rishikesh, India.

Background: Optic disc oedema (ODE) is an important manifestation in various ocular as well as systemic disorders. Measurement of retinal nerve fibre layer (RNFL) thickness in ODE patients may help in monitoring the progress of the disease and treatment response.

Objective: To assess the clinical characteristics, aetiology and retinal nerve fibre layer (RNFL) imaging features of optic disc oedema (ODE) patients. Read More

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February 2022

Glaucomatous Type Cupping Caused by Internal Carotid Artery Compression: a Case Report.

J Cent Nerv Syst Dis 2022 14;14:11795735221081588. Epub 2022 Feb 14.

Department of Ophthalmology, De Girocoli Hospital, Conegliano, Italy.

A 71-year-old woman with a diagnosis of normal tension glaucoma (NTG) presented with complains of progressive visual loss in the right eye. Examination revealed features consistent with compressive optic neuropathy. Although brain magnetic resonance imaging (MRI) was initially interpreted as normal, re-evaluation disclosed a compression on the right optic nerve from the right internal carotid artery. Read More

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February 2022

Orbital Ependymoma.

Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):e51-e54

Texas A&M College of Medicine, College Station, Texas.

Orbital ependymomas are rare in the orbit and usually occur secondary to extracerebral extension of an intraventricular ependymoma. The authors present a rare case of orbital ependymoma in a 74-year-old female. The patient was initially diagnosed with intraventricular ependymoma at the age of 13 years that required multiple repeat craniotomies for tumor recurrence. Read More

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Predictive value of OCT and MRI for postoperative visual recovery in patients with chiasmal compressive lesions.

Eur J Ophthalmol 2022 Jan 10:11206721211073216. Epub 2022 Jan 10.

Department of Ophthalmology, 220312School of Medicine, Pusan National University Hospital, South Korea.

Purpose: We aimed to investigate the predictive value of retinal thickness measured by optical coherence tomography (OCT) and mass biometrics measured using magnetic resonance image (MRI) for visual recovery after surgery for removal of a mass compressing the optic chiasm.

Methods: Consecutive patients who showed typical temporal visual field defect (VFD) with respect to the vertical meridian due to a chiasmal compressive mass and who underwent mass removal surgery were recruited. Ophthalmic examination was performed preoperatively and postoperatively. Read More

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January 2022

Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer.

Nat Biomed Eng 2022 Jan 6. Epub 2022 Jan 6.

Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.

The clinical diagnostic evaluation of optic neuropathies relies on the analysis of the thickness of the retinal nerve fibre layer (RNFL) by optical coherence tomography (OCT). However, false positives and false negatives in the detection of RNFL abnormalities are common. Here we show that an algorithm integrating measurements of RNFL thickness and reflectance from standard wide-field OCT scans can be used to uncover the trajectories and optical texture of individual axonal fibre bundles in the retina and to discern distinctive patterns of loss of axonal fibre bundles in glaucoma, compressive optic neuropathy, optic neuritis and non-arteritic anterior ischaemic optic neuropathy. Read More

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January 2022

The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves' Ophthalmopathy.

Biomedicines 2021 Dec 10;9(12). Epub 2021 Dec 10.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Graves' ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves' disease. It is characterized initially by an inflammatory process, followed by tissue remodeling and fibrosis, leading to proptosis, exposure keratopathy, ocular motility limitation, and compressive optic neuropathy. The pathogenic mechanism is complex and multifactorial. Read More

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December 2021

Bilateral Sequential Non-arteritic Anterior Ischemic Optic Neuropathy (NAION).

Cureus 2021 Nov 9;13(11):e19408. Epub 2021 Nov 9.

Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS.

This is a case report of a rare case of bilateral sequential non-arteritic anterior ischemic optic neuropathy (NAION). A 50-year-old Indian gentleman, who is a known case of diabetes and an active smoker, presented with a right eye painless inferior visual field defect upon waking up from sleep. Fundoscopy revealed swollen right optic disc with peripapillary splinter hemorrhage while Humphrey visual field (HVF) showed right inferior altitudinal scotoma. Read More

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November 2021

Successful Treatment of Bilateral Compressive Optic Neuropathy With Teprotumumab.

J Neuroophthalmol 2021 Dec 16. Epub 2021 Dec 16.

Division of Neuro-ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

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December 2021

Orbital Radiation for Thyroid Eye Disease: A Report by the American Academy of Ophthalmology.

Ophthalmology 2022 04 9;129(4):450-455. Epub 2021 Dec 9.

Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.

Purpose: To review the current literature on the safety and efficacy of orbital radiation for the management of thyroid eye disease (TED).

Methods: A literature search was conducted last in February 2021 of the PubMed database to identify all articles published in the English language on original research that assessed the effect of orbital radiation on TED. The search identified 55 articles, and 18 met the inclusion criteria for this assessment. Read More

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Compressive Optic Neuropathy Secondary to Sinonasal Undifferentiated Carcinoma in a Young Male.

Cureus 2021 Oct 25;13(10):e19042. Epub 2021 Oct 25.

Department of Ophthalmology, 96 Malaysian Armed Forces Hospital, Royal Malaysian Navy Base, Lumut, MYS.

Sinonasal undifferentiated carcinoma (SNUC) is an extremely aggressive malignancy. Extension to the orbit and adjacent structures is common, but isolated visual loss as a presenting symptom is rare. We report a rare case of SNUC with bilateral visual loss as the initial manifestation. Read More

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October 2021

Efficacy and Safety of Teprotumumab in Thyroid Eye Disease.

Ther Clin Risk Manag 2021 25;17:1219-1230. Epub 2021 Nov 25.

Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.

Thyroid eye disease (TED; also known as thyroid-associated ophthalmopathy) is an autoimmune condition with disabling and disfiguring consequences. Teprotumumab is the first and only medication approved by the United States Food and Drug Administration for the treatment of TED. We review the efficacy and safety of teprotumumab in TED, highlighting results from the 2 randomized, double-masked, placebo-controlled trials. Read More

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November 2021

Rare presentation of sarcoidosis with optic neuropathy and third nerve palsy.

BMJ Case Rep 2021 Nov 11;14(11). Epub 2021 Nov 11.

Ophthalmology, King's College Hospital NHS Foundation Trust, London, UK.

Sarcoidosis is a systemic, idiopathic and granulomatous disease, which most commonly affects the skin, lungs and lymph nodes but can affect virtually any organ. Neurosarcoidosis can be the presenting or the only clinical manifestation accounting for 5%-15% of sarcoid diagnoses. In contrast to uveitis which is the most common ophthalmic manifestation, neuro-ophthalmic signs are uncommon in sarcoidosis. Read More

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November 2021

Population-Based Incidence and Outcomes of Compressive Optic Neuropathy.

Am J Ophthalmol 2022 04 22;236:130-135. Epub 2021 Oct 22.

From the Mayo Clinic Alix School of Medicine (A.L.), Department of Ophthalmology (M.T.B., J.C.C.), and Department of Neurology (M.T.B., J.C.C.), Mayo Clinic, Rochester, Minnesota. Electronic address:

Purpose: Prior studies on compressive optic neuropathy (CON) have come from large tertiary centers, which may contain referral bias toward more severe or atypical disease. To our knowledge, there are no studies to determine the population-based etiologies and clinical outcomes of compressive optic neuropathy (CON). This study aims to bridge that gap using the Rochester Epidemiology Project database. Read More

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Compression From Above: A Case Series of Compressive Optic Neuropathy Secondary to Idiopathic Gyrus Rectus Herniation.

J Neuroophthalmol 2021 Jul 14. Epub 2021 Jul 14.

Departments of Ophthalmology and Vision Sciences (SE, EM) and Medical Imaging (LA-S), University of Toronto, Toronto, Canada; and Department of Medicine, Division of Neurology, University of Toronto (EM), Toronto, Canada.

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Anterior clinoid mucocoele presenting as progressive fluctuating visual loss mimicking inflammatory optic neuropathy.

Saudi J Ophthalmol 2021 Jan-Mar;35(1):78-80. Epub 2021 Sep 9.

Department of Neurology, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Optic nerve lesions usually produce monocular visual loss, and in compressive optic neuropathies, gradual vision loss is the more usual presentation. Mucocele in the anterior clinoid process is a rare cause of compressive optic neuropathy that can lead to monocular visual loss. A 19-year-old Sri Lankan girl presented with progressive, painless fluctuating right-sided monocular visual loss over 1-year duration. Read More

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September 2021

A case of brain hamartoma in a child leading to compressive optic neuropathy mimicking amblyopia.

J AAPOS 2021 12 29;25(6):360-362. Epub 2021 Sep 29.

Department of Ophthalmology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma.

Hamartomas are benign neoplastic malformations characterized by disorganized growths of tissue in their native location. They may grow in numerous sites throughout the body. We report the case of a 3-year-old boy with unilateral compressive optic neuropathy caused by a brain hamartoma that mimicked strabismic amblyopia. Read More

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December 2021

Mimics of Optic Neuritis in Neuromyelitis Optica Spectrum Disorder: A Case Report.

Neuroophthalmology 2021 22;45(5):334-338. Epub 2020 Sep 22.

Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

The optic nerve can be involved in a myriad of pathologies underscoring the importance of ruling out both surgical as well as medical causes. Often, it is the temporal profile, clinical presentation and imaging that helps to establish the final diagnosis. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder involving the optic nerves and the spinal cord, which if promptly and adequately managed, may yield gratifying outcomes. Read More

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September 2020

Peripapillary Microvascularization Analysis Using Swept-Source Optical Coherence Tomography Angiography in Optic Chiasmal Compression.

J Ophthalmol 2021 4;2021:5531959. Epub 2021 Sep 4.

Department of Ophthalmology, University Hospital, Dijon, France.

Purpose: To evaluate the vessel density (VD) of the radial peripapillary capillary (RPC) network using swept-source optical coherence tomography angiography (SS-OCTA) "en face" images of eyes with chiasmal compression caused by brain tumors before and after decompressive surgery compared with healthy controls.

Methods: A cross-sectional study was conducted in 12 patients with chiasmal compression confirmed by neuroimaging. Sixteen healthy participants were also included. Read More

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September 2021

Visual fields and optical coherence tomography (OCT) in neuro-ophthalmology: Structure-function correlation.

J Neurol Sci 2021 10 1;429:118064. Epub 2021 Sep 1.

University of Toronto, Faculty of Medicine, Department of Medicine, Division of Neurology, Toronto, Ontario, Canada. Electronic address:

Visual field (VF) testing is an essential component of the neurological examination. The differential diagnosis of VF defects depends on relating this measure of afferent visual function to the structure of the visual pathway and optical coherence tomography (OCT) is an invaluable tool for detailed structural evaluation of the optic nerve and retina. This review describes the ways in which interpretation of VF and OCT can be used together to increase the accuracy of the localization of lesions along the visual pathway. Read More

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October 2021

Efficacy and Safety of Proton Beam Therapy for Primary Optic Nerve Sheath Meningioma.

Eye Brain 2021 24;13:219-229. Epub 2021 Aug 24.

Neurosurgery Department, Hôpital Fondation A. de Rothschild, Paris, France.

Purpose: Management of optic nerve sheath meningiomas (ONSM) remains challenging. Photon radiation therapy (PhRT) is the most common treatment for sight-threatening ONSM. Proton beam therapy (PBT) is less commonly used because it is more expensive and because there are questions about its efficacy specifically in relation to ONSM. Read More

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Bruch Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Helps Differentiate Compressive Optic Neuropathy From Glaucoma.

Am J Ophthalmol 2022 02 25;234:156-165. Epub 2021 Aug 25.

Division of Ophthalmology and the Laboratory of Investigation in Ophthalmology (T.dS.A., A.A.dN.R., L.G.M.M., L.P.C., M.L.R.M), University of São Paulo Medical School, São Paulo, Brazil. Electronic address:

Purpose: To compare optical coherence tomography-measured Bruch membrane opening minimum rim width (MRW), peripapillary retinal nerve fiber layer (pRNFL) measurements, and MRW:pRNFL ratios in eyes with compressive optic neuropathy (CON) and glaucoma and controls, and evaluate the ability of these parameters to differentiate CON from glaucoma.

Design: Prospective, cross-sectional study.

Methods: Setting: Single-center tertiary hospital and outpatient clinic. Read More

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February 2022

Detection of Optic Disc Abnormalities in Color Fundus Photographs Using Deep Learning.

J Neuroophthalmol 2021 Sep;41(3):368-374

Department of Ophthalmology (TYAL, NRM), Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland; Department of Biomedical Engineering (JW), Johns Hopkins University, Baltimore, Maryland; Malone Center for Engineering in Healthcare (HZ, MU), Johns Hopkins University, Baltimore, Maryland; Department of Radiology (PHY, FKH), Johns Hopkins University, Baltimore, Maryland; Singapore Eye Research Institute (DSWT), Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore, Singapore; Department of Ophthalmology (PSS), University of Colorado School of Medicine, Aurora, Colorado; and Department of Ophthalmology (DM), Byers Eye Institute, Stanford University, Palo Alto, California.

Background: To date, deep learning-based detection of optic disc abnormalities in color fundus photographs has mostly been limited to the field of glaucoma. However, many life-threatening systemic and neurological conditions can manifest as optic disc abnormalities. In this study, we aimed to extend the application of deep learning (DL) in optic disc analyses to detect a spectrum of nonglaucomatous optic neuropathies. Read More

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September 2021