596 results match your criteria Optic Neuropathy Compressive


Optical coherence tomography angiography and structural analyses of the pale optic discs: is it possible to differentiate the cause?

Curr Eye Res 2021 May 12. Epub 2021 May 12.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: To compare the optic nerve head (ONH) structure and microvasculature in patients with optic atrophy due to non-arteritic anterior ischemic optic neuropathy (NAION), compressive optic neuropathy (CON), methanol-induced optic neuropathy (MION), and traumatic optic neuropathy (TON) using optical coherence tomography angiography.

Methods: In this comparative, cross-sectional study, 32 eyes with NAION, 18 eyes with CON, 32 eyes with MION, 23 eyes with TON, and 55 normal eyes were enrolled. Radial peripapillary capillary (RPC) vessel density, peripapillary retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, and cup/disc area ratio were obtained using the RTVue XR Avanti system (Optovue Inc. Read More

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Endoscopic Orbital Decompression for Graves' Orbitopathy - A Vietnam Study.

Clin Ophthalmol 2021 22;15:1685-1690. Epub 2021 Apr 22.

Department of Ophthalmology, Hanoi Medical University, Hanoi, Vietnam.

Purpose: To evaluate the efficacy and safety of endoscopic orbital decompression in patients with Graves' orbitopathy.

Patients And Methods: This is a prospective study in Hanoi Medical University and a Military Hospital from December 2017 to December 2018. Twenty-eight orbits of fifteen patients were undergoing endoscopic orbital decompression for Graves' orbitopathy. Read More

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Teprotumumab for the treatment of mild compressive optic neuropathy in thyroid eye disease: A report of two cases.

Am J Ophthalmol Case Rep 2021 Jun 17;22:101075. Epub 2021 Mar 17.

Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Purpose: To report two cases of thyroid eye disease (TED) associated compressive optic neuropathy (CON) that resolved after treatment with teprotumumab.

Observation: Two patients presented with active TED resulting in mild CON with the typical corresponding visual field (VF) defects. Both patients were initiated on intravenous (IV) corticosteroid therapy but despite treatment had persistent VF defects. Read More

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Teprotumumab: The Dawn of Therapies in Moderate-to-Severe Thyroid-Associated Ophthalmopathy.

Horm Metab Res 2021 Apr 14;53(4):211-218. Epub 2021 Apr 14.

Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

Thyroid-associated ophthalmopathy (TAO) is a potentially sight-threatening ocular disease. About 3-5% of patients with TAO have severe disease with intense pain, inflammation, and sight-threatening corneal ulceration or compressive optic neuropathy. The current treatments of TAO are often suboptimal, mainly because the existing therapies do not target the pathogenesis of the disease. Read More

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Evaluating the interreader agreement and intrareader reproducibility of Visual Field Defects in Thyroid Eye Disease- Compressive Optic Neuropathy.

Eye (Lond) 2021 Apr 8. Epub 2021 Apr 8.

Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.

Purpose: To categorize visual field (VF) defects according to Freitag and Tanking's (FT) classification in Thyroid Eye Disease-Compressive Optic Neuropathy (TED-CON) and evaluate the interreader agreement and intrareader reproducibility of the classification.

Subjects And Methods: In this retrospective, observational study we included medical reports of 96 eyes (51 patients), who underwent VF testing with TED-CON in Ludwig-Maximilians-University (2008-2019). Two readers separately examined the VFs at the time of the TED-CON diagnosis, each offering two readings of the same VF in a time interval of 1 month. Read More

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The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective.

Handb Clin Neurol 2021 ;178:97-113

Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN, United States.

Optical coherence tomography (OCT) is a noninvasive ocular imaging technique that has become a standard tool in neuroophthalmic practice. Specifically, OCT captures retinal manifestations of neuroaxonal injury caused by lesions along anterior and posterior regions of the afferent visual pathway, in patients presenting with vision loss. More recently, the advent of OCT angiography (OCTA) has enabled evaluation of the choroidal and retinal microvasculature, thus informing our understanding regarding vascular mechanisms associated with optic nerve and retinal injuries. Read More

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January 2021

Electrophysiology in neuro-ophthalmology.

Handb Clin Neurol 2021 ;178:79-96

UCL Institute of Ophthalmology, University College London, London, United Kingdom; Department of Electrophysiology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:

This chapter reviews common applications of visual electrophysiology relevant to neuro-ophthalmology practice. The use of standard tests and extended protocols are described including the cortical visual evoked potential and pattern and full-field electroretinogram (PERG; ERG) methods, the latter including the photopic negative response. Abnormalities of these recordings are rarely specific but provide valuable diagnostic guidance and an objective measure of visual pathway function, difficult or impossible to infer by other methods. Read More

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January 2021

Compressive optic neuropathy (CON) in Graves' disease caused by hypertrophy of levator and superior rectus muscles: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25062

Department of Ophthalmology, Osaka Medical College, Osaka, Japan.

Rationale: Enlargemento of the medial rectus is the most predominant factor of compressive optic neuropathy (CON) in Graves' disease. This case report indicates that CON could develop only from the hypertrophic superior levator and superior rectus (SL/SR) muscle in a patient with poorly controlled Graves' disease, and described the possible risk of FT3-thyrotoxicosis with a prominent goiter to develop the current rare case with a review of the literature.

Patient Concerns: A 66-year-old woman undergoing endocrine management of hyperthyroidism with prominent goiter visited the Department of Ophthalmology due to right-eye upper-eyelid retraction. Read More

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Approach to patient with unilateral optic disc edema and normal visual function.

J Neurol Sci 2021 05 24;424:117414. Epub 2021 Mar 24.

University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada; University of Toronto, Faculty of Medicine, Department of Medicine, Division of Neurology, Toronto, Ontario, Canada. Electronic address:

In patients with swollen optic nerve head and normal visual function, optic disc drusen (ODD) is the most common diagnosis. The best tests for detecting ODD are funds autofluorescence and enhanced-depth imaging ocular coherence tomography (EDIOCT). After ODD has been ruled out, asymmetric papilledema should be assumed to be the cause and MRI of the brain and orbits with contrast and venography should be performed in all patients. Read More

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Meningiomas of the Planum Sphenoidale and Tuberculum Sella.

J Neurol Surg B Skull Base 2021 Feb 12;82(1):72-80. Epub 2021 Feb 12.

Department of Ophthalmology, Sue Anschutz-Rodgers UCHealth Eye Center, University of Colorado School of Medicine, Aurora, Colorado, United States.

Patients with meningiomas of the planum sphenoidale and tuberculum sella often present with insidious vision loss in one or both eyes as the only sign or symptom of their disease, although other sensory, oculomotor, and even endocrine abnormalities may be seen in a minority of cases. Incidentally discovered tumors also are common, as patients may undergo neuroimaging for unrelated symptoms or events. Depending on the size and orientation of the tumor, central vision loss from optic nerve compression may be a later sign, and loss of peripheral vision in one or both eyes may not be recognized until it has progressed to areas closer to fixation. Read More

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February 2021

Conservative Management of Traumatic Optic Neuropathy Secondary to Lateral Orbital Wall Fracture.

S D Med 2020 Dec;73(12):582-585

University of South Dakota Sanford School of Medicine.

Purpose: To inform rural healthcare providers about the early identification and management of traumatic optic neuropathy (TON). Specifically, we seek to legitimize expectant management as a viable approach to such cases.

Observations: A 27-year-old female with direct posterior compressive TON with associated visual field and visual acuity deficit was managed expectantly without steroids or surgical intervention. Read More

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December 2020

Partial Vision Loss After Orbital Decompression in a Patient With Thyroid Eye Disease, Chorioretinal Folds, and Disc Edema.

J Neuroophthalmol 2021 Feb 19. Epub 2021 Feb 19.

Department of Ophthalmology (LD, AQT, AT, IB), New York University, New York, New York; Department of Ophthalmology (AQT, AT), Manhattan Eye, Ear, and Throat Hospital, Northwell Health, New York, New York; and Department of Ophthalmology (VIE), New York Eye and Ear Infirmary of Mount Sinai, New York, New York.

Abstract: Concomitant chorioretinal folds with disc edema can be seen in cases of thyroid eye disease presenting with compressive optic neuropathy and may portend optic nerve ischemia. We describe an unusual case of a 64-year-old man who developed partial vision loss after orbital decompression. Read More

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February 2021

Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1.

Gene Ther 2021 Feb 15. Epub 2021 Feb 15.

University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.

SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either neighboring cells or RGC specifically. We investigated the neuroprotective potential of RGC-selective SIRT1 gene therapy in the optic nerve crush (ONC) model. Read More

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February 2021

Multimodal imaging in a case of compressive optic neuropathy.

J Fr Ophtalmol 2021 Feb 9. Epub 2021 Feb 9.

Department of Ophthalmology, Charles-Nicolle university hospital, Faculty of medecine of Tunis, boulevard du 9-avril-1938, 1006 Tunis, Tunisia.

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February 2021

Bilateral dysthyroid compressive optic neuropathy responsive to teprotumumab.

Eur J Ophthalmol 2021 Feb 1:1120672121991042. Epub 2021 Feb 1.

Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, OH, USA.

Thyroid eye disease is an auto-immune mediated orbitopathy which can cause dysthyroid compressive optic neuropathy. Traditional management of active thyroid eye disease includes temporizing high-dose steroids, orbital radiation and surgical decompression, which each possess significant limitations and/or side effects. Teprotumumab is an IGF-IR inhibitor recently FDA-approved for active thyroid eye disease. Read More

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February 2021

Teprotumumab in Clinical Practice: Recommendations and Considerations From the OPTIC Trial Investigators.

J Neuroophthalmol 2021 Jan 4;Publish Ahead of Print. Epub 2021 Jan 4.

Department of Surgery (RSD, YW), Division of Ophthalmology, Cedars Sinai Medical Center, Los Angeles, California; State Key Laboratory of Ophthalmology (RSD), Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Department of Ophthalmology (RAD), Casey Eye Institute, Portland, Oregon; Department of Ophthalmology (GJH), Medical College of Wisconsin, Milwaukee, Wisconsin; Bascom Palmer Eye Institute (STW), University of Miami, Miami, Florida; Eye Wellness Center-Neuro-Eye Clinical Trials (JSS, RAT), Inc, Houston, Texas; Hamilton Eye Institute (BF, JF), University of Tennessee Health Science Center, Memphis, Tennessee; and Department of Ophthalmology and Visual Sciences (TJS), Kellogg Eye Center, and Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan.

Background: Thyroid eye disease (TED) is a vision-threatening and debilitating condition that until very recently had no Food and Drug Administration (FDA)-approved medical therapies. Teprotumumab has recently been approved to treat TED. We aim to provide guidance for its use, based on the input of the US investigators who participated in Phase 2 and Phase 3 clinical trials. Read More

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January 2021

Progressive subcutaneous emphysema and compressive optic neuropathy following dental analgesia.

J Am Coll Emerg Physicians Open 2020 Dec 5;1(6):1278-1280. Epub 2020 Oct 5.

Department of Surgery Utah Emergency Physicians Salt Lake City Utah USA.

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December 2020

Compressive Optic Neuropathy with a Concurrent Mutation of Leber's Hereditary Optic Neuropathy: A Case Report.

Neuroophthalmology 2020 28;44(6):387-390. Epub 2020 Jan 28.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Leber's hereditary optic neuropathy (LHON) is a mitochondrial genetic disease that leads to acute or subacute, painless, bilateral loss of vision, caused by degeneration of retinal ganglion cells that most affects men in their second or third decade of life. We describe a woman with compressive optic neuropathy with a concurrent LHON-associated mitochondrial mutation. Temporal hemifield defect connected to central scotoma and concurrent abduction limitation are diagnostic clues in identifying chiasmal compression with craniopharyngioma. Read More

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January 2020

The Value of Macular Optical Coherence Tomography in Watchful Waiting of Suprasellar Masses: A 2-Year Observational Study.

J Neuroophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Departement of Ophthalmology (ØKJ, ARW, MCM), Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine (ØKJ, MCM), Faculty of Medicine, University of Oslo, Oslo, Norway; The Integrative Pituitary Team (ØKJ, ARW, PBM, JAE), Oslo University Hospital, Oslo, Norway; Section of Neuroradiology (PBM), Oslo University Hospital, Oslo, Norway; and Section of Specialized Endocrinology (JAE), Oslo University Hospital, Oslo, Norway.

Background: A possible benefit of optical coherence tomography (OCT) in the approach to tumors involving the optic chiasm may be the ability to foresee visual deterioration. This study investigated the value of OCT in watchful waiting for compressive optic neuropathy as the primary management of suprasellar masses.

Methods: The research was conducted as a 2-year observational study of a patient cohort with conservatively managed mass lesions involving the optic chiasm on MRI. Read More

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Intravascular Papillary Endothelial Hyperplasia as a Cause of Reversible Vision Loss.

J Craniofac Surg 2020 Nov 23. Epub 2020 Nov 23.

Department of Ophthalmology and Vision Sciences.

Intravascular papillary endothelial hyperplasia (IPEH) is a benign vascular lesion that is formally diagnosed on histopathology. IPEH seldom presents in periocular tissues and is even less commonly seen deep within the orbit. As with cavernous hemangioma, this lesion tends to distort surrounding structures and can cause a significant mass effect in the orbit. Read More

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November 2020

Orbital decompressive effect of endoscopic transorbital surgery for sphenoorbital meningioma.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 23;259(4):1015-1024. Epub 2020 Nov 23.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro Kangnam-ku, Seoul, 06351, South Korea.

Purpose: This study was aimed at evaluating the orbital decompressive effect of endoscopic transorbital approach (TOA) in the management of sphenoorbital meningioma involving the orbit.

Methods: Patients treated with TOA for this tumor from December 2016 to December 2019 were included, and the data were reviewed. Pre- and postoperative clinical and imaging findings were compared with a volumetric study. Read More

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Orbital cysticercosis: clinical features and management outcomes.

Orbit 2020 Oct 27:1-7. Epub 2020 Oct 27.

Orbit, Oculoplasty, Reconstructive & Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Chennai, India.

Aim: To describe the clinical and radiological features of orbital cysticercosis and its management outcome.

Material And Method: A retrospective analysis of consecutive cases of orbital cysticercosis between January 2008 and January 2018. The management outcome was classified into good, fair, and poor depending upon the resolution of the clinical features and status of the cyst and scolex in the imaging studies. Read More

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October 2020

Compressive Optic Disc Edema and Contralateral Papilledema: Type 2 Foster Kennedy Variant Syndrome.

J Neuroophthalmol 2020 Oct 22. Epub 2020 Oct 22.

Baylor College of Medicine (JZ, AGL), Houston, Texas; Department of Ophthalmology (SHB, NB, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; The Houston Methodist Research Institute (AGL), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology (AGL), Neurology, and Neurosurgery, Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), Bryan, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

A 43-year-old woman presented with progressive anosmia, self-neglect, and lethargy for 1 year. Brain MRI demonstrated a mass that was compressing the optic nerve in the right eye and had a significant mass effect and cerebral edema producing increased intracranial pressure. Examination revealed the patient to have a variant of Foster Kennedy syndrome involving ipsilateral compressive optic neuropathy with superimposed optic disc edema and contralateral papilledema. Read More

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October 2020

Contour Variability in Thyroid Eye Disease with Compressive Optic Neuropathy Treated with Radiation Therapy.

Adv Radiat Oncol 2020 Sep-Oct;5(5):804-808. Epub 2020 Feb 29.

Department of Radiation Oncology, Columbia University Medical Center, New York, New York.

Purpose: Few studies have evaluated the methodology by which radiation therapy (RT) for thyroid eye disease and compressive optic neuropathy is performed. The objective of this study was to retrospectively review our experience from a radiation planning standpoint and to determine whether current treatment methods provide adequate dose to target and collateral structures.

Methods: A retrospective review of 52 patients (104 orbits) with bilateral thyroid eye disease and compressive optic neuropathy treated with RT (20 Gy in 10 fractions) at our institution. Read More

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February 2020

Orbital Compartment Syndrome After High-speed Air-Gasoline Blast Injury.

Ophthalmic Plast Reconstr Surg 2020 Oct 16. Epub 2020 Oct 16.

Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas*Baylor College of Medicine, Houston, Texas, U.S.A.

Orbital compartment syndrome is an ophthalmologic emergency that requires timely surgical intervention. The authors present a rare case of orbital compartment syndrome in a 30-year-old male injured by forceful entry of air-gasoline mixture into the orbit, secondary to inadvertent firing of the piston from running mechanical diagnostics on an automobile internal combustion engine. Orbital CT revealed extensive orbital emphysema with both pre- and postseptal involvement and diffuse chemical cellulitis. Read More

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October 2020

[Optic Neuropathy Secondary to Compression by the Internal Carotid Artery Concomitant with an Inflammatory Granuloma:A Case Report].

No Shinkei Geka 2020 Oct;48(10):957-961

Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui.

A 77-year-old man presented with a 6-month history of progressive right optic neuropathy secondary to compression by the ipsilateral internal carotid artery(ICA). We performed anterior clinoidectomy and optic canal unroofing. Subsequently, we wrapped the ICA with a polytetrafluoroethylene tape, pulled the vessel laterally, and sutured the tape to the dura mater at the anterior skull base for optimal decompression. Read More

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October 2020

A retrospective study of pediatric thyroid eye disease: the Asian experience.

Orbit 2020 Oct 15:1-10. Epub 2020 Oct 15.

Singapore National Eye Centre, Singapore, Singapore.

Aim: To study the clinical presentation, disease characteristics, and management approach for children with thyroid eye disease (TED) over a 10 year period in a multidisciplinary Paediatric Thyroid Eye Disease Clinic at a tertiary care referral center.

Methods: Retrospective case series of patients with TED at Kandang Kerbau Women's and Children's Hospital (KKWCH) Singapore between August 2006 to June 2015. The diagnosis of TED was clinical based on the Bartley criteria. Read More

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October 2020

Superior ophthalmic vein thrombosis post manual carotid compression for indirect carotid-cavernous fistula.

Orbit 2020 Oct 9:1-5. Epub 2020 Oct 9.

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To report 5 cases of superior ophthalmic vein thrombosis (SOVT) following intermittent manual carotid compression (IMCC) for indirect carotid-cavernous fistula (CCF) and to outline the management.

Methods: Retrospective observational case series of all patients who developed SOVT secondary to IMCC for indirect low flow CCF's at a tertiary care center. The demographic profile, clinical, imaging findings, treatment, and outcomes were studied. Read More

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October 2020

Efficacy of orbital radiotherapy in moderate-to-severe active graves' orbitopathy including long-lasting disease: a retrospective analysis.

Radiat Oncol 2020 Sep 21;15(1):220. Epub 2020 Sep 21.

Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Background: We aimed to explore the efficacy of orbital radiotherapy (RT) in patients with moderate-to-severe active Graves' orbitopathy (GO), including long-lasting disease, and to determine the predictive factors associated with treatment response.

Methods: This was a retrospective study of 62 moderate-to-severe active GO patients treated with RT. Demographic data and ophthalmic findings prior to RT and at 3 and 6 months afterward were analyzed. Read More

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September 2020