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Case Rep Ophthalmol 2019 Jan-Apr;10(1):11-18. Epub 2019 Jan 16.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Invasive aspergillosis is often fatal. Here, we report a patient with invasive aspergillosis primarily involving the optic nerve diagnosed on autopsy.

Case Presentation: A 77-year-old female with underlying diabetes mellitus, hyperlipidemia, and hypertension presented with disc swelling of the left eye. Read More

Minerva Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Opthalmology, Shanxi Provincial People's Hospital, Taiyuan, China.

J Autoimmun 2019 Feb 5. Epub 2019 Feb 5.

Service de Médecine Interne-DHU i2B, Hôpital Saint-Antoine, APHP, 75012, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, France. Electronic address:

Acute cerebrovascular ischemic events are a rare and severe complication of giant cell arteritis (GCA). We aimed to determine the prevalence of GCA-related stroke, the overall survival and the relapse-free survival in patients with GCA. A multicentric retrospective analysis was performed on 129 patients with GCA diagnosed between September 2010 and October 2018 in two University Hospitals. Read More

Arq Bras Oftalmol 2019 Mar-Apr;82(2):155-157

Department of Neuro-radiology, Sheikh Khalifa Hospital, Abu Dhabi, UAE.

Numerous studies have reported on structural vascular anomalies and ischemia associated with neurofibromatosis type 1 that are thought to stem from dysfunction of neurofibromin, the neurofibromatosis type 1 protein. Documented cases of associated antiphospholipid syndrome fulfilling the accepted diagnostic criteria are exceptionally rare, with only three cases reported in the literature. Here, we report on a patient with neurofibromatosis type 1 and a history of spontaneous abortions presenting with sudden vision loss in the right eye and swelling of the optic nerve head. Read More

Neuroophthalmology 2019 Feb 19;43(1):43-48. Epub 2018 Jun 19.

Hospital Pedro Hispano, Matosinhos, Portugal.

Hypotension is the most frequent complication of haemodialysis. We report a case of acute visual impairment after one session of haemodialysis in a context of an acute optic neuropathy. The immunological and serological studies were negative. Read More

Eye Vis (Lond) 2019 6;6. Epub 2019 Jan 6.

2Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136 USA.

Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in patients over 50 years of age, and many affected individuals are left with permanent visual deficits. Despite the frequency of NAION and its often devastating effects on vision, no effective treatment has been established. Further understanding of the acute vascular effects in NAION, using advanced ophthalmic imaging techniques like the retinal function imager, may shed light on potential treatment targets. Read More

Chin Med Sci J 2018 12;33(4):252-259

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Objective To assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). Methods rNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours after the induction of disease. Read More

Am J Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Purpose: To determine whether nonarteritic ischemic optic neuropathy (NAION) raises the risk of subsequent stroke in the general population.

Design: Population-based, retrospective cohort study METHODS: Setting: Nationwide, population-based, retrospective cohort study.

Patients: Of 1,025,340 beneficiaries in the National Health Insurance Service-National Sample Cohort database (2002-2013), we included 400,952 eligible individuals in the analysis. Read More

J Glaucoma 2018 Dec 28. Epub 2018 Dec 28.

RWTH Aachen University, Dept. of Ophthalmology, Pauwelsstr.30, 52072 Aachen.

Purpose: To evaluate ocular hemodynamics in patients with a disease believed to be related to a chronic vascular damage (i.e. normal tension glaucoma, NTG) in comparison to an entity with an acute ischemic impact on the optic nerve (i. Read More

BMC Ophthalmol 2018 Dec 29;18(1):341. Epub 2018 Dec 29.

Department of Ophthalmology, Beijing Friendship Hospital, the Second Clinical Medical College of Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, People's Republic of China.

Background: This study aimes to characterize the fundus structural changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and the correlation between macular vessel density, retinal nerve fibre layer (RNFL) parameters and visual field sensitivity (VFS) in NAION patients.

Methods: A retrospective case control study was performed using 37 eyes with NAION, 30 uninvolved contralateral eyes, and 27 eyes of healthy age-matched subjects. Data on the retinas and choroidal vessel densities and VFS were compared among the three groups. Read More

BMC Neurol 2018 Dec 27;18(1):220. Epub 2018 Dec 27.

Department of Pathophysiology and Transplantation, Dino Ferrari Centre, University of Milan, Milan, Italy.

Background: Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss consequent to optic nerve atrophy. In some cases, LHON is associated with heterogeneous neurological extraocular manifestations and is referred to as "Leber plus disease"; rarely it is associated with a multiple sclerosis (MS)-like syndrome known as Harding disease, but no pediatric extraocular acute spinal onset is reported.

Case Presentation: We describe the case of a 5-year-old girl carrying the G3460A mtDNA mutation who was referred to clinical examination for bilateral upper and lower limb weakness with no sign of optic neuropathy. Read More

Neurologist 2019 Jan;24(1):26-28

Hospital Italiano de Buenos Aires, Argentina.

Giant cell arteritis is a large vessel vasculitis with neurological manifestations that range from visual disturbances to ischemic stroke. Among the former, visual acuity and visual field defects are prevalent, with anterior ischemic optic neuropathy being their most frequent cause. We present a clinical case in which the presenting ocular feature of the disease was a peripheral monocular visual field defect secondary to optic perineuritis. Read More

Indian J Ophthalmol 2019 Jan;67(1):177-178

Neuro-Ophthalmology Services, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, L.V. Prasad Marg, Banjara Hills, Hyderabad, Telangana, India.

Indian J Ophthalmol 2019 Jan;67(1):176-177

Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1091, USA.

Indian J Ophthalmol 2019 Jan;67(1):142

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Exp Eye Res 2018 Dec 15;181:105-111. Epub 2018 Dec 15.

Institute of Eye Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Reproducible skills are essential for successful induction of a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by measuring the natural course of optic nerve head (ONH) width and retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. Read More

BMC Ophthalmol 2018 Dec 12;18(1):317. Epub 2018 Dec 12.

Neurology division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia of the anterior portion of the optic nerve, and less frequently simultaneous.

Case Presentation: An 80-year-old Saudi male came with a history of simultaneous bilateral vision loss 5 days prior to presentation. Read More

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.

Ceyhan State Hospital Ophthalmology Department, Adana, Turkey.

The study was aimed to present a rare case of who developed non arteritic anterior ischemic optic neuropathy (NAION) following robotic-assisted gynaecologic surgery. A 58-year-old female patient presented with vision loss in right eye after non-complicated robotic-assisted total hysterectomy and bilateral salpingo-oopherectomy. We observed on fundoscopy optic disc edema and splinter hemorrhages at the optic disc edges. Read More

Rom J Ophthalmol 2018 Jul-Sep;62(3):231-245

"Prof. Dr. Agrippa Ionescu" Clinical Emergency Hospital, Bucharest, Romania.

We present a case of Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION) with uncertain etiology but a good recovery with a total gain of central visual acuity. Read More

BMC Ophthalmol 2018 Nov 22;18(1):304. Epub 2018 Nov 22.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, NO.100, Haining Road, Hongkou District, Shanghai, 200080, China.

Background: A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further investigated.

Methods: Photodynamic treatment was conducted on the optic nerve head (ONH) following administration of the photosensitizer. Read More

Curr Opin Neurol 2019 Feb;32(1):19-24

Department of Ophthalmology.

Purpose Of Review: To review recent advances in the management of acute ocular ischemic events, including: transient monocular vision loss, central and branch retinal artery occlusions, and nonarteritic anterior ischemic optic neuropathy.

Recent Findings: Transient monocular vision loss and acute retinal arterial occlusions require immediate diagnosis and management, with recognition of these events as transient ischemic attack or stroke equivalents, respectively. Patients should undergo an immediate stroke workup in a stroke center, similar to patients with acute cerebral ischemia. Read More

CEN Case Rep 2018 Nov 21. Epub 2018 Nov 21.

University of Toronto, Department of Ophthalmology and Vision Sciences, 801 Eglinton Ave West Suite 301, Toronto, ON, M5N 1E3, Canada.

Nonarteritic anterior ischemic optic neuropathy (NAION) is a well acknowledged rare complication of chronic hemodialysis in patients with end-stage renal disease (ESRD). We present a unique case of a patient on chronic hemodialysis who presented with an NAION in the right eye, then 3 months later developed an NAION in the left eye followed in 1 month by second NAION episode in the left eye. Every episode of NAION was accompanied by intradialytic hypotension (drop in systolic blood pressure of over 20 mmHg) where visual loss was noticed at the end of the dialysis session. Read More

Curr Opin Neurol 2019 Feb;32(1):124-130

Save Sight Institute, The University of Sydney.

Purpose Of Review: Obstructive sleep apnea (OSA) is increasing in prevalence. The intermittent hypoxia of OSA has wide-ranging effects on a patient's general health outcomes. However, gold-standard investigations and treatment are expensive and a significant burden on patients. Read More

Br J Ophthalmol 2018 Nov 9. Epub 2018 Nov 9.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background/aims: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population.

Methods: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications. Read More

BMC Ophthalmol 2018 Oct 30;18(1):282. Epub 2018 Oct 30.

Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: Giant cell arteritis (GCA) is a systemic vasculitis of medium and large-size vessels and can led to permanent visual loss in elderly patients. GCA is very rare among Asians. We report a Chinese patient presenting with acute bilateral anterior ischemic optic neuropathy, and the temporal artery biopsy proved the diagnose of GCA. Read More

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

Aerosp Med Hum Perform 2018 Nov;89(11):1005-1007

Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic neuropathy with the exact pathophysiology unknown. Risk factors include advanced age, small optic nerve head, hypertension, diabetes mellitus, and sleep apnea. High altitude is considered another risk factor, although only few cases have been reported. Read More

J Neuroophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals older than 50 years. Demographic, ocular, and systemic risk factors for NAION have been identified, and we sought to determine which, if any, of these factors also increase risk of NAION in the fellow eye.

Methods: We performed a retrospective chart review of patients with "ischemic optic neuropathy" (based on International Classification of Disease [ICD] codes) seen at a single eye center between 2007 and 2017. Read More

J Neuroophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Save Sight Institute, Discipline of Ophthalmology, Faculty of Medicine and Health Sciences, University of Sydney, Sydney, Australia; Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Obstructive sleep apnea (OSA) is a common pulmonary disorder with many systemic sequelae. Its association with diseases seen in neuro-ophthalmology is being increasingly recognized. Treatment of OSA with continuous positive airway pressure (CPAP) may reverse the pathology in some eye diseases. Read More

Curr Eye Res 2018 Dec 1;43(12):1489-1499. Epub 2018 Oct 1.

a Departments of Ophthalmology , Stanford University School of Medicine , Stanford , CA , USA.

Purpose: Brain-derived neurotrophic factor (BDNF) and activation of its high affinity receptor tropomyosin kinase (Trk) B promote retinal ganglion cells (RGCs) survival following injury. In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years.

Methods: We assessed drug effects on immunopanned, cultured RGCs and calculated RGC survival and assessed TrkB receptor activation by mitogen-activated protein (MAP) kinase translocation. Read More

Transl Vis Sci Technol 2018 Sep 26;7(5):10. Epub 2018 Sep 26.

Department of Ophthalmology, University of Colorado, School of Medicine, Aurora, CO, USA.

Purpose: This study compares macular and parafoveal vasculature in patients with optic disc swelling.

Methods: Twenty eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 39 eyes with papilledema at first presentation, and 22 eyes of normal subjects were imaged using optical coherence tomography angiography (OCT-A). Macular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer thicknesses were measured in addition to macula and parafovea superficial and deep vasculature. Read More

Neuroophthalmology 2018 Oct 9;42(5):287-294. Epub 2018 Jan 9.

Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

The aim of this study was to assess the possible relationship between AAION (arteritic anterior ischemic optic neuropathy) and NAION (non-arteritic anterior ischemic optic neuropathy) with blood platelet parameters and NLR (neutrophil-to-lymphocyte ratio). The medical records of 12 patients with AAION, 33 patients with NAION, and 35 healthy subjects were examined. MPV, PDW, and PCT values showed marked elevation in AAION and NAION groups compared with control group. Read More

Chin Med J (Engl) 2018 Oct;131(19):2357-2359

Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei 063000, China.

Acta Ophthalmol 2018 Dec 21;96(8):e1018-e1024. Epub 2018 Sep 21.

Department of Ophthalmology and Optometry, Medical University Vienna, Vienna, Austria.

Purpose: Optic nerve head (ONH) parameters as well as circumpapillary retinal nerve fibre layer (RNFL) thickness values measured with two different spectral domain optical coherence tomography (SD-OCT) machines (Spectralis and Cirrus OCT) have been compared between two patient groups, primary open-angle glaucoma (POAG), nonarteritic anterior ischaemic optic neuropathy (NAION) and healthy controls. A comparison of the performance of the two OCT machines was made.

Methods: Twenty healthy controls, 20 POAG and 20 NAION patients with comparable visual field defects were included. Read More

BMJ Case Rep 2018 Sep 19;2018. Epub 2018 Sep 19.

Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.

A retired businessman presented to the infectious diseases department with a history of ongoing fevers and myalgia and raised inflammatory markers. This continued despite adequate antibiotic treatment of an epididymo-orchitis. Extensive investigations, including bone marrow and liver biopsies and a positron emission tomography, did not reveal a cause but showed reactive change in the bone marrow. Read More

J Res Pharm Pract 2018 Jul-Sep;7(3):164-167

Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Erectile dysfunction (ED) has negative effects on quality of life. The first line of oral medication for this condition is phosphodiesterase type 5 inhibitors (PDE5I) including Tadalafil. Ocular complications associated with Tadalafil are rare and usually occurred in participant with known risk factors. Read More

Rom J Ophthalmol 2018 Apr-Jun;62(2):138-143

Frelance Physician, Diyarbakır, Turkey.

We aimed to investigate the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell complex (mGCC) thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy (crNAION) analyzed by spectral domain optical coherence tomography (SD-OCT). Patients with crNAION, and healthy control subjects were enrolled in the study. All participants underwent SD-OCT for measurement of pRNFL, mGCC, and central macular thickness (CMT). Read More

Turk J Ophthalmol 2018 Aug 4;48(4):202-205. Epub 2018 Sep 4.

University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey.

In this study, we present a case of bilateral optic neuropathy and macular ischemia in the right eye associated with neurosarcoidosis. A 26-year-old woman presented to our clinic with complaints of bilateral blurred vision. Bilateral granulomatous anterior uveitis, vitritis, optic neuropathy, and macular ischemia were detected in the right eye in slit-lamp examination. Read More

Ophthalmic Plast Reconstr Surg 2018 Sep 4. Epub 2018 Sep 4.

Department of Ophthalmology and Shanghai Key Laboratory of Visual Impairment and Restoration, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.

Purpose: This study aimed to evaluate the effects of retinal artery occlusions caused by cosmetic facial filler injections on the retrobulbar blood flow parameters.

Methods: This was a retrospective, noncomparative case series. Ten consecutive patients with fundus artery occlusions caused by facial filler injections were evaluated using color Doppler flow imaging (CDFI). Read More

J Clin Neurol 2018 Oct 6;14(4):577-579. Epub 2018 Sep 6.

Department of Neurology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, Korea.

J Neuroophthalmol 2019 Mar;39(1):14-17

Background: While often idiopathic, anterior ischemic optic neuropathy occasionally may occur from an identifiable cause.

Methods: Observational case report.

Results: A 19-year-old woman with unremarkable medical and ophthalmic histories developed visual loss from nonarteritic anterior ischemic optic neuropathy in her right eye after otherwise uneventful dental extraction of the inferior third molars. Read More

Acta Ophthalmol 2019 Feb 31;97(1):e64-e70. Epub 2018 Aug 31.

Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in old age. Although there are several known risk factors, the influence of obstructive sleep apnoea (OSA) has not been completely elucidated. The aim of this study was to evaluate the association between NAION and OSA. Read More

BMC Ophthalmol 2018 Aug 28;18(1):211. Epub 2018 Aug 28.

Department Of Ophthalmology, Faculty of Medicine, Taif University, Taif, Saudi Arabia.

Background: Sickle cell disease is a common inherited hemoglobinopathy and is associated with high morbidity and mortality. Vaso-occlusive crises commonly occur in individuals with SCD that results in high morbidity due to end-organ ischemia and infarction. These include splenic infarction, pulmonary involvement, acute chest syndrome, and orbital compression syndrome. Read More

Am J Ophthalmol 2018 Nov 8;195:199-208. Epub 2018 Aug 8.

Department of Ophthalmology, Duke Eye Center and Duke University Medical Center, Durham, North Carolina, USA. Electronic address:

Purpose: To use spectral-domain optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of nonarteritic anterior ischemic optic neuropathy (NAION).

Design: Retrospective cohort study.

Methods: Setting: Single academic center. Read More

Invest Radiol 2018 Nov;53(11):698-704

Radiologisches Zentrum Rosenheim, Rosenheim, Germany.

Objectives: Arteritic anterior ischemic optic neuropathy (A-AION) caused by inflammatory occlusion of the posterior ciliary arteries is the most common reason for irreversible vision loss in patients with giant cell arteritis. Atypical clinical presentation and negative funduscopy can delay systemic high-dose corticosteroid therapy to prevent impending permanent blindness and involvement of the contralateral eye.The purpose of this study was to assess the diagnostic accuracy of 3-dimensional (3D) high-resolution T1-weighted black-blood magnetic resonance imaging (T1-BB-MRI) for the detection of posterior ciliary artery involvement in patients with giant cell arteritis and funduscopic A-AION. Read More

Front Neurol 2018 10;9:557. Epub 2018 Jul 10.

Departments of Ophthalmology and Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, United States.

Perioperative visual loss (POVL) is a rare, serious complication of non-ophthalmic surgeries. Ischemic optic neuropathy (ION), and retinal arterial occlusion (RAO) are the main causes (1, 2). Less frequent are cortical blindness (3), acute glaucoma (4), and choroidal and vitreous hemorrhage (5). Read More

Ophthalmic Epidemiol 2018 Oct - Dec;25(5-6):386-391. Epub 2018 Jul 24.

b Neurology , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

Purpose: To estimate the population-based incidence of acute idiopathic optic neuritis (ON) and analyse its differential diagnosis in patients referred with symptoms suggestive of ON.

Methods: Patients with suspected ON referred to the Helsinki University Hospital, serving a population of 1.5 million in Southern Finland, were reviewed between 1st May 2008 and 14th April 2012. Read More

Indian J Ophthalmol 2018 08;66(8):1144-1148

Neuro-Ophthamology Services, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: The purpose of this study is to detect the optic nerve head (ONH) and peripapillary perfusion in eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION) compared to the fellow normal eyes using optical coherence tomography angiography (OCTA) and to compare with nonischemic disc edema (papilledema).

Methods: Retrospective analysis of patients with unilateral NAION who underwent OCTA was performed. All patients underwent comprehensive ocular examination including visual field testing. Read More

J Ocul Pharmacol Ther 2018 Jul/Aug;34(6):432-435. Epub 2018 Jul 13.

2 Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine , One Hospital Drive, Columbia, Missouri.

Purpose: To evaluate possible associations between oral anti-vascular endothelial growth factor (VEGF) drugs and ocular side effects.

Methods: Spontaneous reports were collected and evaluated by the National Registry of Drug-Induced Ocular Side Effects on the three oral anti-VEGF drugs (pazopanib, sorafenib, and sunitinib) for possible ocular side effects.

Results: Reported side effects include blurred or decreased vision (389 cases); periocular or eyelid edema (273 cases); superficial anterior segment toxicity (270 cases); conjunctival, retinal, or vitreous bleeding (77 cases); retinal detachments (RDs) or retinal tears (RTs) (75 cases); extraocular muscle disorders, including ptosis (51 cases); discoloration of eyelashes (36 cases); retinal arterial or venous occlusions (26 cases); optic nerve disorders, including papilledema and ischemic optic neuropathy (21 cases); uveitis (10 cases); and macular edema (7 cases). Read More