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Sci Rep 2020 Jun 25;10(1):10351. Epub 2020 Jun 25.

Institute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Non-arteritic anterior ischemic optic neuropathy (NAION) causes a sudden loss of vision and lacks effective treatment. Granulocyte colony-stimulating factor (G-CSF) provides neuroprotection against the experimental optic nerve injuries but also induce leukocytosis upon typical administration. We found synergetic neuroprotective effects of meloxicam and low dose G-CSF without leukocytosis in a rat model of anterior ischemic optic neuropathy (rAION). Read More

Int J Ophthalmol 2020 18;13(6):960-964. Epub 2020 Jun 18.

Department of Ophthalmology, the First People's Hospital of Xianyang, Xianyang 712000, Shaanxi Province, China.

Aim: To investigate the correlation of ischemic ophthalmopathy (IO) with lacunar infarction (LI), an ischemic lesions in the cerebrovascular system.

Methods: Totally 204 cases of IO without any nervous system symptom and previously diagnosed LI served as the observational group. All 204 cases without IO, nervous system symptoms and previous LI served as the control group. Read More

BMC Ophthalmol 2020 Jun 17;20(1):236. Epub 2020 Jun 17.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, 510060, China.

Background: To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients.

Methods: Patients at Zhongshan Ophthalmic Center with recent-onset (< 8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. Read More

Graefes Arch Clin Exp Ophthalmol 2020 Jun 6. Epub 2020 Jun 6.

Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USA.

Background: To evaluate the effect of systemic erythropoietin, as well as oral steroids, in the management of recent-onset non-arteritic anterior ischemic optic neuropathy (NAION).

Method: Patients diagnosed with NAION within 5 days were randomized into group A (systemic erythropoietin), group B (oral steroids), and group C (control). Group A received 10,000 units of erythropoietin twice a day for 3 days. Read More

Int Ophthalmol 2020 Jun 3. Epub 2020 Jun 3.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung City, 833, Taiwan, R.O.C..

Purpose: To investigate the natural course, visual outcome, and risk factors for visual loss after nonarteritic anterior ischemic optic neuropathy (NAION) attack in Chinese patients from a tertiary medical center in Southern Taiwan.

Methods: This is a longitudinal observational study that included sixty NAION patients, who were seen in our neuro-ophthalmology clinic from 2007 to 2016. Records of their ophthalmic history, medical history, best-corrected visual acuity (BCVA), visual field (VF) testing, and optical coherence tomography (OCT) were obtained for analysis. Read More

Eye (Lond) 2020 Jun 3. Epub 2020 Jun 3.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Aim: To assess the visual acuity at the end of life in glaucoma suspect patients, ocular hypertension, and patients treated for glaucoma and to find factors contributing to a reduced visual acuity in this cohort of deceased patients.

Methods: In a cohort of 3883 medically treated glaucoma patients, glaucoma suspect, or patients with ocular hypertension assembled in 2001-2004, 1639 were deceased. Patient data were collected from electronic and paper patient files. Read More

Neurol Sci 2020 Jun 1. Epub 2020 Jun 1.

Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.

Optic nerve head drusen (ONHD) are typically benign hyaline and calcified concretions located within the optic nerve. Initially asymptomatic, they can increase slowly in size and number over time, and they can cause mechanical stress at the axons of the optic nerve and progressively lead to a loss of the visual field and papillary vascular changes. Here, we reported a rare case of a young patient with bilateral ONHD complicated by a nonarteritic anterior ischemic optic neuropathy (NAION) in the right eye. Read More

Clin Rheumatol 2020 May 29. Epub 2020 May 29.

Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHULN, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Giant cell arteritis (GCA) is a granulomatous vasculitis involving large- and middle-sized arteries, with a predilection for cranial arteries. In this paper, we aim to describe a case of a biopsy- and ultrasound-proven GCA, presenting with anterior ischemic optic neuropathy (AION) and normal CRP and ESR at diagnosis and during follow-up, and to review the literature on GCA cases with low inflammatory markers, with a particular focus on the presence of eye involvement. Both CRP and ESR are important in the diagnosis of GCA; occurrence of this disease with normal acute phase reactants is unusual but does not rule out the diagnosis. Read More

J Fr Ophtalmol 2020 Jun 22;43(6):552-558. Epub 2020 May 22.

Service d'ophtalmologie, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France. Electronic address:

Ischemic optic neuropathies include any vascular disease of the optic nerve. Anterior ischemic optic neuropathies are classically distinguished from posterior ischemic optic neuropathies by the presence of optic disc edema in the former, and the absence thereof in the latter. Non-arteritic acute anterior ischemic optic neuropathy is the most common ischemic optic nerve disease. Read More

J Neuroophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Department of Ophthalmology, Callahan Eye Hospital, Birmingham, Alabama.

Klin Monbl Augenheilkd 2020 May 20. Epub 2020 May 20.

Augenklinik, Universitätsklinikum Ulm, Ulm.

Can J Ophthalmol 2020 May 13. Epub 2020 May 13.

Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ont.; Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ont.. Electronic address:

Objective: Giant cell arteritis (GCA) is the most common primary vasculitis affecting the elderly population. GCA preferentially involves the extracranial branches of the carotid artery; intracranial vasculitis is thought to be a rare occurrence. This study determined the prevalence of intracranial vasculitis in a large series of patients evaluated for GCA and describes the clinical presentation of such cases. Read More

Cureus 2020 Apr 13;12(4):e7662. Epub 2020 Apr 13.

Allergy and Immunology, Rutgers New Jersey Medical School, Newark, USA.

This case report represents a rare life-threatening hypersensitivity reaction of tocilizumab drug when it is used to treat giant cell arteritis. An elderly female with history of bilateral giant cell arteritis with anterior ischemic optic neuropathy of the right eye was started on tocilizumab after developing glucocorticoid-related complications. She received one month of the tocilizumab therapy along with the prednisone taper. Read More

Int Ophthalmol 2020 May 7. Epub 2020 May 7.

Department of Biomedical Science, Humanitas University, 20090, Pieve Emanuele, Milano, Italy.

Background: Optic disc drusen (ODD) are acellular deposits in the prelaminar optic nerve head. The most accredited theory is that they are secondary to abnormalities in axonal metabolism and degeneration, but the pathogenesis is not clear to date.

Clinical Manifestation: Although ODD are often considered a benign condition, the great majority of patients with ODD show visual field defects and are at higher risk for developing anterior ischemic optic neuropathy. Read More

Graefes Arch Clin Exp Ophthalmol 2020 May 6. Epub 2020 May 6.

Department of Ophthalmology, Myongji hospital, College of Medicine, Hanyang University, Goyang, South Korea.

Background: We aimed to evaluate the current practice patterns of neuro-ophthalmologists in diagnosis and management of three optic neuropathies using a national survey in South Korea and to further compare the practices of neuro-ophthalmologists divided into junior and senior groups based on their clinical practice experience.

Methods: An anonymous, 15-question survey on the diagnosis and treatment of traumatic optic neuropathy (TON), nonarteritic anterior ischemic optic neuropathy (NAION), and Leber's hereditary optic neuropathy (LHON) was sent to all neuro-ophthalmologists registered with the Korean Neuro-ophthalmology Society. The questions addressed physician's practice duration as neuro-ophthalmologist, choices of MRI scans and laboratory tests for the diagnosis in suspected optic neuropathy, clinical experiences with steroids (e. Read More

J Neuroophthalmol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Neurological Sciences (Neurology) (JAF), Western University, London, Canada; Department of Ophthalmology (JAF), Western University, London, Canada; and Department of Ophthalmology (LLR, LM, SH), Rigshospitalet, University of Copenhagen, Glostrup, Denmark.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) in young patients (age ≤50) accounts for a minority of all cases of NAION and is more highly associated with crowding of the optic nerves and bilateral involvement than NAION in older patients. Optic disc drusen (ODD) are likewise associated with crowded optic nerves and are located in the prelaminar optic nerve head where they could contribute to NAION pathogenesis. The purpose of this study was to determine the prevalence of ODD in the eyes of young NAION patients using modern imaging methods and to compare it to the baseline 1. Read More

J Neuroophthalmol 2020 Apr 28. Epub 2020 Apr 28.

University of Southern California, Roski Eye Institute, Keck School of Medicine, Los Angeles, California.

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):201-209. Epub 2020 Apr 6.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To assess the use of temporal artery biopsy (TAB) in diagnosing giant cell arteritis (GCA) and to evaluate patients' clinical and laboratory characteristics.

Methods: We conducted a retrospective chart review of patients with suspected GCA who underwent TAB and had complete workup in a tertiary center in Iran between 2008 and 2017. The 2016 American College of Rheumatology (ACR) revised criteria for early diagnosis of GCA were used for each patient for inclusion in this study. Read More

Am J Ophthalmol 2020 Apr 13. Epub 2020 Apr 13.

Save Sight Institute, Faculty of Health and Medicine, The University of Sydney, Australia.

Purpose: Optic disc drusen (ODD), present in 2% of the general population, have occasionally been reported in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION). The purpose of this study was to examine the prevalence of ODD in young patients with NA-AION.

Design: retrospective, cross-sectional multicenter study. Read More

J Clin Med 2020 Apr 12;9(4). Epub 2020 Apr 12.

Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy.

The aim of this study was to perform quantitative optical coherence tomography angiography (OCTA) assessment of arteritic and non-arteritic anterior ischemic optic neuropathies (AION; NAION). The study was designed as an observational, cross-sectional case series. All patients underwent complete ophthalmologic evaluation including LogMAR best-corrected visual acuity (BCVA), structural optical coherence tomography (OCT) and OCTA images, and dye-based angiography. Read More

CEN Case Rep 2020 Apr 13. Epub 2020 Apr 13.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, 801 Eglinton Ave West, Suite 301, Toronto, ON, M5N 1E3, Canada.

Case Rep Nephrol 2020 16;2020:7012586. Epub 2020 Mar 16.

Division of Nephrology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada.

Anterior ischemic optic neuropathy (AION) occurs due to hypoperfusion of the optic nerve and is a rare complication in patients receiving maintenance dialysis. To date, AION has only been reported in 22 children, all of whom were receiving peritoneal dialysis. We report the first case of AION in a 2-year 11-month-old child receiving chronic hemodialysis secondary to polycystic kidney disease from a phosphomannomutase 2 gene mutation. Read More

J Neuroophthalmol 2020 Mar 24. Epub 2020 Mar 24.

Department of Neuro-Ophthalmology, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, India

J Neuroophthalmol 2020 Mar 26. Epub 2020 Mar 26.

Department of Ophthalmology (RCF, MTB, JJC), Mayo Clinic; Mayo Clinic (OMC), College of Medicine, Rochester, Minnesota; and Departments of Health Sciences Research (ERL, DOH), and Neurology (MTB, JPK, JJC), Mayo Clinic, Rochester, Minnesota.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in adults and is associated with vascular risk factors. Owing to the overlapping risk factor profiles between NAION and cerebral stroke, previous studies have produced conflicting results with regard to NAION as an independent risk factor for stroke.

Methods: A retrospective chart review was conducted using the Rochester Epidemiology Project database to identify all cases of NAION occurring among Olmsted County, Minnesota residents from January 1, 1990, through December 31, 2016. Read More

J Neuroophthalmol 2020 Mar 26. Epub 2020 Mar 26.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.

Clin Ophthalmol 2020 11;14:775-793. Epub 2020 Mar 11.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Medical School, Bari, Italy.

Purpose: Giant cell arteritis (GCA), a chronic vasculitis of the large and medium-sized arteries, affects people >50 years of age. This study assessed the prevalence of visual manifestations and other clinical features at presentation in an Italian cohort of GCA patients. Recent advances in the pathophysiology, diagnosis, and therapy of GCA are also reviewed. Read More

J Neuroophthalmol 2020 Mar 23. Epub 2020 Mar 23.

MultiCare Rockwood Clinic (RE), Spokane, Washington; Department of Ophthalmology (ACA), Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California; Blanton Eye Institute (AGL), Houston Methodist Hospital, Houston, Texas; and Department of Ophthalmology and Visual Sciences (GVS), Washington University in St. Louis, St. Louis, Missouri.

Semin Arthritis Rheum 2020 Apr;50(2):335-341

Department of Internal Medicine, Caen University Hospital, Avenue de la Côte de Nacre, 14000 Caen, France. Electronic address:

Purpose: To describe the characteristics and outcome of patients with giant-cell arteritis (GCA)-related ophthalmologic involvement at diagnosis.

Methods: In a retrospective single-center cohort of 409 consecutive patients with GCA, we retrieved 104 patients with visual symptoms at GCA diagnosis and we compared them to 104 age- and sex-matched controls without ophthalmologic involvement. Each visual symptom was associated to an ophthalmologic diagnosis that was centrally re-assessed by an ophthalmologist. Read More

Invest Ophthalmol Vis Sci 2020 03;61(3):35

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Purpose: To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between nonarteritic anterior ischemic optic neuropathy (NAION) and primary open angle glaucoma (POAG).

Methods: Thirty-seven eyes with chronic NAION, 34 unaffected fellow eyes with NAION, 47 moderate and severe POAG eyes, and 54 healthy control subjects were evaluated. Automated PPCMv density was calculated using custom Matlab software in inner and outer annuli around the optic nerve region in addition to peripapillary superficial retinal vessels. Read More

J Neuroophthalmol 2020 Jun;40(2):271-273

Department of Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, California.

Saudi J Biol Sci 2020 Mar 8;27(3):820-826. Epub 2020 Jan 8.

Department of Neurosurgery, Weifang People's Hospital Shandong Province, Weifang 261021, China.

In this study, 50 patients with anterior ischemic optic neuropathy due to saddle block were selected as the experimental group, and 50 healthy subjects were used as the control group to conduct a study. The best corrected visual acuity examination, optical coherence tomography and visual evoked potential examination were performed on the two groups. The results of the study showed that the majority of patients were middle-aged and older people over the age of 50, but the youngest patients were only 37 years old. Read More

J Fr Ophtalmol 2020 Apr 24;43(4):294-297. Epub 2020 Feb 24.

Service d'ophtalmologie, hôpital Mohamed Taher Maamouri, Mrazka, 8000 Nabeul, Tunisie.

Factor V is a pro-coagulant cofactor required for the transformation of prothrombin into thrombin. Thrombin activates factor V, which is then deactivated by protein C. A mutation in factor V is responsible for the formation of factor V Leiden, resistant to activated protein C. Read More

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):59-68. Epub 2020 Feb 2.

Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USA.

Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls.

Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy-four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SD-OCT). Read More

J Fr Ophtalmol 2020 May 21;43(5):e189-e192. Epub 2020 Feb 21.

Department of ophthalmology, university hospital Gregorio Marañón, Madrid, Spain.

J Fr Ophtalmol 2020 Mar 11;43(3):256-270. Epub 2020 Feb 11.

Service d'ophtalmologie III, CHNO des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France; Inserm-DHOS CIC 1423, CHNO des Quinze-Vingts, IHU FOReSIGHT, 75012 Paris, France; Inserm, U968, Inserm-DHOS CIC 503, UPMC Université Paris 06, UMR_S968, CNRS, UMR 7210, institut de la Vision, CHNO des Quinze-Vingts, 75012 Paris, France; Service d'ophtalmologie, université de Versailles Saint-Quentin-en-Yvelines, hôpital Ambroise-Paré, AP-HP, 92100 Versailles, France. Electronic address:

Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. Read More

J Neuroophthalmol 2020 Jan 29. Epub 2020 Jan 29.

Department of Ophthalmology (BAAO, ATK, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Department of Ophthalmology (MN), USC Roski Eye Institute, Keck Medicine of USC, Los Angeles, California; Departments of Ophthalmology (AGL), Neurology, and Neurosurgery, Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (AGL), University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Ophthalmology (AGL), Texas A and M College of Medicine, Bryan, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Shock-induced anterior ischemic optic neuropathy (SIAION) is a known type of optic neuropathy in patients who experienced shock related to different etiologies such as anemia and severe intradialytic hypotension like in our patient. Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute unilateral known type of optic neuropathy in older patients with vasculopathic risk factors such as hypertension, diabetes mellitus, and obstructive sleep apnea. Although SIAION and NAION are similar optic neuropathies due to ischemia and, in particular, hypotension, they may have different pathogenic mechanisms (e. Read More

Med Image Anal 2020 04 28;61:101660. Epub 2020 Jan 28.

Univ Bretagne Occidentale, Brest, F-29200, France; Inserm, UMR 1101, Brest, F-29200, France; Service d'Ophtalmologie, CHRU Brest, Brest, F-29200, France.

In the last decades, large datasets of fundus photographs have been collected in diabetic retinopathy (DR) screening networks. Through deep learning, these datasets were used to train automatic detectors for DR and a few other frequent pathologies, with the goal to automate screening. One challenge limits the adoption of such systems so far: automatic detectors ignore rare conditions that ophthalmologists currently detect, such as papilledema or anterior ischemic optic neuropathy. Read More

Mar Drugs 2020 Jan 27;18(2). Epub 2020 Jan 27.

Institute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Background: We investigated the therapeutic effects and related mechanisms of algae oil (ALG) to protect retinal ganglion cells (RGCs) in a rat model of anterior ischemic optic neuropathy (rAION).

Methods: Rats were daily gavaged with ALG after rAION induction for seven days. The therapeutic effects of ALG on rAION were evaluated using flash visual evoked potentials (FVEPs), retrograde labeling of RGCs, TUNEL assay of the retina, and ED1 staining of optic nerves (ONs). Read More

Prog Retin Eye Res 2020 Jan 23:100840. Epub 2020 Jan 23.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea. Electronic address:

Neuroretinal rim thinning (NRR) is a characteristic glaucomatous optic disc change. However, the precise mechanism of the rim thinning has not been completely elucidated. This review focuses on the structural role of the glioarchitecture in the formation of the glaucomatous NRR thinning. Read More

J Neuroophthalmol 2020 Jan 16. Epub 2020 Jan 16.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.

Background: Nonarteritic anterior ischemic optic neuropathy (NA-AION) associated with optic disc drusen (ODD) is termed ODD-AION, where NA-AION with no evidence of ODD is simply termed NA-AION. Patients with ODD-AION have been found to be younger than those with NA-AION but with similar vascular risk factors. This study compares the known risk factors for NA-AION between a group with ODD-AION and a similarly aged group with NA-AION. Read More

Int Ophthalmol 2020 May 20;40(5):1269-1276. Epub 2020 Jan 20.

Ophthalmology Department, Zagazig University, Zagazig, Egypt.

Purpose: To assess the peripapillary perfusion in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA).

Methods: Twenty-five patients with unilateral acute NAION were included in this observational cross-sectional study. They were divided into two groups: group I (25 eyes) included eyes with acute NAION, and group II (25 eyes) included fellow normal eyes. Read More

Am J Ophthalmol Case Rep 2020 Mar 7;17:100593. Epub 2020 Jan 7.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Patients may lose vision in idiopathic intracranial hypertension from worsening papilledema and optic nerve dysfunction. Acute vision loss may also occur in this context from anterior ischemic optic neuropathy. We report a case of a 29-year-old woman with bilateral moderate papilledema from idiopathic intracranial hypertension who experienced sudden loss of vision in the superior part of the visual field of her right eye. Read More

Int J Ophthalmol 2020 18;13(1):120-123. Epub 2020 Jan 18.

Neuro-Ophthalmology Service, Aravind Eye Hospital, Coimbatore 641014, India.

Aim: To elucidate the changes of different ganglion cell layer (GCL) thinning patterns between the optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION).

Methods: A prospective, observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence tomography.

Results: Thinning on optical coherence tomography in the NAION group occurs as early as 11d after symptomatic onset of vision loss and follows an altitudinal pattern. Read More

J Fr Ophtalmol 2020 Feb 15;43(2):e41-e54. Epub 2020 Jan 15.

Ophthalmology Service III, CHNO des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France; Inserm-DHOS CIC 1423, CHNO des Quinze-Vingts, IHU FOReSIGHT, Paris, France; Inserm, U968; Inserm-DHOS CIC 503, UPMC Univ Paris 06, UMR_S968, CNRS, UMR 7210, institut de la Vision, CHNO des Quinze-Vingts, Paris, France; Ophthalmology service, université de Versailles Saint-Quentin-en-Yvelines, hôpital Ambroise-Paré, AP-HP, Versailles, France. Electronic address:

Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. Read More

Acta Biomed 2019 12 23;90(4):583-586. Epub 2019 Dec 23.

Ospedale Luigi Sacco, Milano.

Introduction: Postoperative vision loss (PVL) is an extremely rare complication following major surgical procedures. Patients with systemic hypertension, diabetes, coronary diseases and smokers are generally predisposed to this complication. More frequently, it is caused by ischemic optic neuropathy (ION), central retinal artery occlusion or retinal vein occlusion. Read More

Transl Vis Sci Technol 2019 Nov 20;8(6):47. Epub 2019 Dec 20.

Department of Ophthalmology and Visual Sciences, University of Maryland at Baltimore-School of Medicine, Baltimore, MD, USA.

Purpose: Nonarteritic anterior ischemic optic neuropathy (NAION) is the leading cause of sudden optic nerve-related vision loss currently without effective treatment. We evaluated the neuroprotective potential of ocular (topical) delivery of trabodenoson, a selective A receptor mimetic, in a rodent model of NAION (rNAION).

Methods: Daily topical delivery of 3% trabodenoson or vehicle administered in both eyes 3 days prior to rNAION induction and for 21 days post induction. Read More

Semin Neurol 2019 12 17;39(6):673-681. Epub 2019 Dec 17.

Division of Neuro-ophthalmology, Departments of Neurology and Ophthalmology, Indiana University School of Medicine, Indianapolis.

Giant cell arteritis (GCA) is the most common vasculitis in individuals 50 years or older, with a lifetime risk in the United States of 1% in women and 0.5% in men. It is a granulomatous disease that affects large- and medium-sized vessels, most notably the branches of the internal and external carotid arteries. Read More

Autoimmun Rev 2020 Feb 13;19(2):102446. Epub 2019 Dec 13.

Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France Sorbonne Université, France; Sorbonne Universités, INSERM U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. Electronic address:

Introduction: Myelodysplastic syndromes (MDS) and MDS/myeloproliferative neoplasms (MDS/MPN) can be associated with giant cell arteritis (GCA). In this nationwide study by the "French Network of dysimmune disorders associated with hemopathies" (MINHEMON) the objective was to evaluate characteristics, treatment and outcome of GCA MDS-MDS/MPN.

Patients And Methods: Retrospective analysis of patients that presented a MDS or MDS/MPN associated with GCA. Read More

Medicina (B Aires) 2019 ;79(6):509-512

Cirugía Vascular, Clínica Hispano Argentina de Tres Arroyos, Provincia de Buenos Aires, Argentina.

Giant cell arteritis is a systemic vasculitis that affects arteries of medium and large caliber, mainly the aorta artery and its main branches. It is more frequent in women older than 50 years. The most common symptoms are fever, jaw claudication, headache, hyperesthesia of the scalp and loss of vision with anterior ischemic optic nerve disease. Read More

BMJ Case Rep 2019 Dec 1;12(11). Epub 2019 Dec 1.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada

Non-arteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in older individuals but may also occur in younger patients. A 30-year-old man presented with a 2-day history of right eye painless vision loss and was found to have right optic disc oedema and a left 'disc-at-risk'. He was diagnosed with right NAION and review of symptoms revealed witnessed apnea at night and episodes where he woke up gasping for air, concerning for obstructive sleep apnea (OSA). Read More