1,499 results match your criteria Optic Neuropathy Anterior Ischemic


Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of ophthalmology, University Hospital of Grenoble-Alpes, France; Grenoble-Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble-Alpes, Grenoble, France. Electronic address:

Purpose: The pathophysiology of non-arteritic AION (N-AION) is not completely understood. Studies of the retinal vasculature phenotype in patients with N-AION could help us to understand vascular abnormalities associated with the disease.

Design: Retrospective case series with matched controls. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.007DOI Listing

Early Ganglion Cell or Macular Vessel Loss After Acute Nonarteritic Anterior Ischemic Optic Neuropathy?

Transl Vis Sci Technol 2019 Apr 4;8(2):12. Epub 2019 Apr 4.

Department of Ophthalmology, Neurology, and Neurosurgery, University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1167/tvst.8.2.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450639PMC

Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 4. Epub 2019 Apr 4.

Ophthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.

Purpose: To compare choroidal vascularity index (CVI) in patients with arteritic anterior ischemic optic neuropathy (A-AION), non-arteritic anterior ischemic optic neuropathy (NA-AION) and control subjects.

Design: Retrospective cross-sectional study.

Methods: This study was conducted at the Ophthalmology Unit of the S. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.028DOI Listing

Visual loss post Ross procedure in an adolescent with newly diagnosed Mucopolysaccharidosis Type II.

Ann Thorac Surg 2019 Apr 3. Epub 2019 Apr 3.

Congenital Cardiology Directorate, Royal Brompton & Harefield NHS Trust, Sydney Street, London, UK. Electronic address:

Perioperative visual loss is a rare but serious complication after cardiac surgery. Despite this, its etiology is not fully understood and there is no consensus on the optimal management of this condition. A 15-year-old male developed severe visual impairment attributed to non-arteritic anterior ischemic optic neuropathy after a Ross aortic root replacement procedure. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.011DOI Listing
April 2019
2 Reads

[Acute visual loss related to sphenoid meningioma].

J Fr Ophtalmol 2019 Mar 26. Epub 2019 Mar 26.

Département d'ophtalmologie, DHU vision et handicaps, hôpital Pitié-Salpêtrière, 47-92, boulevard de l'Hopital, 75013 Paris, France. Electronic address:

Meningiomas represent about 20% of intracranial tumors. Involvement of the medial sphenoid wing includes anterior clinoid, cavernous sinus and superior orbital fissure meningiomas. Due to the proximity of these tumors to the optic nerve, typically progressive unilateral vision loss, over several months to years, is the classic clinical presentation. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.12.006DOI Listing
March 2019
2 Reads

Optical Coherence Tomography Angiography of a Pale Optic Disc in Demyelinating Optic Neuritis and Ischemic Optic Neuropathy.

J Neuroophthalmol 2019 Mar 18. Epub 2019 Mar 18.

Farabi Eye Hospital (MAF, SY, HG, SM), Eye Research Center, Department of Ophthalmology, Tehran University of Medical Science, Tehran, Iran; Department of Ophthalmology (RSM), Rasht University of Medical Science, Rasht, Iran; and Department of Ophthalmology, Neurology, and Neurosurgery (PSS), University of Colorado School of Medicine, Aurora, Colorado.

Background: In the setting of a pale optic disc, distinguishing a previous episode of optic neuritis (ON) from that of nonarteritic anterior ischemic optic neuropathy (NAION) may be difficult on clinical examination. Differences in peripapillary vascular network structures, if present, might be of diagnostic utility.

Methods: Thirty-five eyes with demyelinating ON, 33 eyes with NAION, and 81 eyes of normal subjects were imaged with optical coherence tomography angiography (OCT-A) to assess peripapillary vascular density (VD). Read More

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http://dx.doi.org/10.1097/WNO.0000000000000775DOI Listing
March 2019
9 Reads

[The clinical analysis of optic neuropathy relative to Behcet's disease with clinical manifestation of anterior ischemic optic neuropathy].

Zhonghua Yan Ke Za Zhi 2019 Mar;55(3):203-207

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To summarize the clinical manifestation, treatment and prognosis of anterior ischemic optic neuropathy(AION) which was the manifestation of optic neuropathy related with Behcet's disease (BD). Retrospective series of case studies. The clinical data of 6 cases (9 eyes) of AION associated with BD who were hospitalized at the neurology ward of Beijing Tongren Hospital from February to June in 2016 were collected, the clinical characteristics of these patients were summarized, visual acuity were compared by using Wingerchuk visual grade before and after treatment. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.03.009DOI Listing
March 2019
9 Reads

[Vessel density and structure in the macular region of non-arteritic anterior ischemic optic neuropathy patients].

Zhonghua Yan Ke Za Zhi 2019 Mar;55(3):195-202

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To explore the correlation between the vessel density and the structure and visual function in patients with non-arteritic anterior ischemic optic neuropathy (NAION) in different stages. This case-control study included 25 NAION patients (28 eyes)of Peking Union Medical College Hospital from November 2017 to May 2018 and 25 healthy controls(HC) (25 eyes) of matched age and gender. General eye examination, visual field examination, and optical coherence tomography angiography were performed to obtain data of blood flow in the macular area and structure such as ganglion cell complex (GCC) and gross loss of volume (GLV), and focal loss of volume (FLV). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.03.008DOI Listing
March 2019
2 Reads

[Pay attention to the quality of evidence research for appropriate evaluation of the treatment trail of the non-arteritic anterior ischemic optic neuropathy].

Authors:
Y Zhong T Chen

Zhonghua Yan Ke Za Zhi 2019 Mar;55(3):164-168

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in people aged 50 and above. The precise mechanism of NAION remains unclear and no consistently effective treatment, either medical or surgical method, for NAION has been identified. Thus, further study of the pathogenesis, higher research level of the treatment trail and the effective neuroprotective approaches are of significant importance for the treatment of NAION. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.03.002DOI Listing
March 2019
3 Reads

Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy.

Eye (Lond) 2019 Mar 4. Epub 2019 Mar 4.

Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Purpose: To investigate whether the serum total oxidant status (TOS), total antioxidant status (TAS), advanced oxidation protein products (AOPP), and thiol parameters could play a role in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NA-AION).

Methods: In this study, 18 newly diagnosed NA-AION patients and 17 healthy subjects (control group) were included. Serum plasma TOS and TAS, AOPP, and thiol parameters were measured by spectrophotometric method and the results were compared. Read More

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http://dx.doi.org/10.1038/s41433-019-0388-0DOI Listing
March 2019
3 Reads

Ischemic Optic Neuropathy following Spine Surgery: Case Series and Systematic Review of the Literature.

Spine (Phila Pa 1976) 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

MINI: Spine surgery remains one of the most common causes of perioperative vision loss due to ischemic optic neuropathy. We present a case series and systematic review of the literature to illustrate risk factors and prognosis and highlight the need for better reporting of this rare but devastating complication of spine surgery.

Study Design: Case control analysis and systematic literature review. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003010DOI Listing
February 2019
1 Read

Sex Hormones and Optic Nerve Disorders: A Review.

Front Neurosci 2019 11;13:57. Epub 2019 Feb 11.

Laboratory of Neuroendocrinology, Department of Neuroscience Rita Levi-Montalcini, University of Turin, Turin, Italy.

This review article presents a comprehensive overview of the literature on sex hormones (estrogens, androgens, progesterone) and optic nerve disorders, with a discussion of the implications for therapy and prevention. Epidemiological, pre-clinical and clinical studies were reviewed. Analysis of the biological basis for a relationship between eye diseases and sex hormones showed that some types of hormones can exert a protective effect either directly on the retina and optic nerve or indirectly by modulating ocular blood flow. Read More

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http://dx.doi.org/10.3389/fnins.2019.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378504PMC
February 2019
3 Reads

The Difficulty of Diagnosing Invasive Aspergillosis Initially Manifesting as Optic Neuropathy.

Case Rep Ophthalmol 2019 Jan-Apr;10(1):11-18. Epub 2019 Jan 16.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Invasive aspergillosis is often fatal. Here, we report a patient with invasive aspergillosis primarily involving the optic nerve diagnosed on autopsy.

Case Presentation: A 77-year-old female with underlying diabetes mellitus, hyperlipidemia, and hypertension presented with disc swelling of the left eye. Read More

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http://dx.doi.org/10.1159/000495979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381903PMC
January 2019
2 Reads

A comparative study on clinical features of anterior ischemic optic neuropathy and idiopathic optic neuritis.

Minerva Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Opthalmology, Shanxi Provincial People's Hospital, Taiyuan, China.

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http://dx.doi.org/10.23736/S0026-4806.19.05976-7DOI Listing
February 2019
1.202 Impact Factor

Ischemic stroke in giant-cell arteritis: French retrospective study.

J Autoimmun 2019 May 5;99:48-51. Epub 2019 Feb 5.

Service de Médecine Interne-DHU i2B, Hôpital Saint-Antoine, APHP, 75012, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, France. Electronic address:

Acute cerebrovascular ischemic events are a rare and severe complication of giant cell arteritis (GCA). We aimed to determine the prevalence of GCA-related stroke, the overall survival and the relapse-free survival in patients with GCA. A multicentric retrospective analysis was performed on 129 patients with GCA diagnosed between September 2010 and October 2018 in two University Hospitals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183073
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http://dx.doi.org/10.1016/j.jaut.2019.01.009DOI Listing
May 2019
12 Reads

Antiphospholipid syndrome and neurofibromatosis type I: a coincidence or new association?

Arq Bras Oftalmol 2019 Mar-Apr;82(2):155-157

Department of Neuro-radiology, Sheikh Khalifa Hospital, Abu Dhabi, UAE.

Numerous studies have reported on structural vascular anomalies and ischemia associated with neurofibromatosis type 1 that are thought to stem from dysfunction of neurofibromin, the neurofibromatosis type 1 protein. Documented cases of associated antiphospholipid syndrome fulfilling the accepted diagnostic criteria are exceptionally rare, with only three cases reported in the literature. Here, we report on a patient with neurofibromatosis type 1 and a history of spontaneous abortions presenting with sudden vision loss in the right eye and swelling of the optic nerve head. Read More

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http://www.gnresearch.org/doi/10.5935/0004-2749.20190032
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http://dx.doi.org/10.5935/0004-2749.20190032DOI Listing
August 2018
18 Reads

Visual Impairment After Haemodialysis.

Neuroophthalmology 2019 Feb 19;43(1):43-48. Epub 2018 Jun 19.

Hospital Pedro Hispano, Matosinhos, Portugal.

Hypotension is the most frequent complication of haemodialysis. We report a case of acute visual impairment after one session of haemodialysis in a context of an acute optic neuropathy. The immunological and serological studies were negative. Read More

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http://dx.doi.org/10.1080/01658107.2018.1471093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351013PMC
February 2019
4 Reads

Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series.

Eye Vis (Lond) 2019 6;6. Epub 2019 Jan 6.

2Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136 USA.

Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in patients over 50 years of age, and many affected individuals are left with permanent visual deficits. Despite the frequency of NAION and its often devastating effects on vision, no effective treatment has been established. Further understanding of the acute vascular effects in NAION, using advanced ophthalmic imaging techniques like the retinal function imager, may shed light on potential treatment targets. Read More

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https://eandv.biomedcentral.com/articles/10.1186/s40662-018-
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http://dx.doi.org/10.1186/s40662-018-0126-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334410PMC
January 2019
7 Reads

Longitudinal Measurement of Hemodynamic Changes within the Posterior Optic Nerve Head in Rodent Nonarteritic Anterior Ischemic Optic Neuropathy.

Chin Med Sci J 2018 12;33(4):252-259

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Objective To assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). Methods rNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours after the induction of disease. Read More

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http://dx.doi.org/10.24920/003477DOI Listing
December 2018
14 Reads

Risk of Stroke After Nonarteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 8;200:123-129. Epub 2019 Jan 8.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea. Electronic address:

Purpose: To determine whether nonarteritic ischemic optic neuropathy (NAION) raises the risk of subsequent stroke in the general population.

Design: Population-based, retrospective cohort study.

Methods: Setting: Nationwide, population-based, retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.12.022DOI Listing
April 2019
1 Read

Ocular Hemodynamics in Acute Nonarteritic Anterior Ischemic Optic Neuropathy Compared With Normal Tension Glaucoma.

J Glaucoma 2019 Apr;28(4):334-340

Department of Ophthalmology, RWTH Aachen University, Pauwelsstr., Aachen, Germany.

Purpose: The purpose of this study was to evaluate ocular hemodynamics in patients with a disease believed to be related to a chronic vascular damage [ie, normal tension glaucoma (NTG)] in comparison with an entity with an acute ischemic impact on the optic nerve [ie, acute nonarteritic anterior ischemic optic neuropathy (NAION)].

Materials And Methods: Blood-flow velocities [peak systolic velocity (PSV), enddiastolic velocity (EDV)] of the ophthalmic artery (OA), central retinal artery (CRA), and nasal and temporal posterior ciliary arteries were measured using color Doppler imaging. Resistive index (RI) of all vessels was calculated (PSV-EDV/PSV). Read More

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http://Insights.ovid.com/crossref?an=00061198-900000000-9823
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http://dx.doi.org/10.1097/IJG.0000000000001177DOI Listing
April 2019
2 Reads

Macular evaluation of the retinal and choroidal vasculature changes in anterior ischemic optic neuropathy-a case control study.

BMC Ophthalmol 2018 Dec 29;18(1):341. Epub 2018 Dec 29.

Department of Ophthalmology, Beijing Friendship Hospital, the Second Clinical Medical College of Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, People's Republic of China.

Background: This study aimes to characterize the fundus structural changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and the correlation between macular vessel density, retinal nerve fibre layer (RNFL) parameters and visual field sensitivity (VFS) in NAION patients.

Methods: A retrospective case control study was performed using 37 eyes with NAION, 30 uninvolved contralateral eyes, and 27 eyes of healthy age-matched subjects. Data on the retinas and choroidal vessel densities and VFS were compared among the three groups. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1007-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311001PMC
December 2018
11 Reads

Subclinical Leber's hereditary optic neuropathy with pediatric acute spinal cord onset: more than meets the eye.

BMC Neurol 2018 Dec 27;18(1):220. Epub 2018 Dec 27.

Department of Pathophysiology and Transplantation, Dino Ferrari Centre, University of Milan, Milan, Italy.

Background: Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss consequent to optic nerve atrophy. In some cases, LHON is associated with heterogeneous neurological extraocular manifestations and is referred to as "Leber plus disease"; rarely it is associated with a multiple sclerosis (MS)-like syndrome known as Harding disease, but no pediatric extraocular acute spinal onset is reported.

Case Presentation: We describe the case of a 5-year-old girl carrying the G3460A mtDNA mutation who was referred to clinical examination for bilateral upper and lower limb weakness with no sign of optic neuropathy. Read More

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http://dx.doi.org/10.1186/s12883-018-1227-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307307PMC
December 2018
21 Reads

Bilateral Optic Perineuritis as Initial Presentation of Giant Cell Arteritis.

Neurologist 2019 Jan;24(1):26-28

Hospital Italiano de Buenos Aires, Argentina.

Giant cell arteritis is a large vessel vasculitis with neurological manifestations that range from visual disturbances to ischemic stroke. Among the former, visual acuity and visual field defects are prevalent, with anterior ischemic optic neuropathy being their most frequent cause. We present a clinical case in which the presenting ocular feature of the disease was a peripheral monocular visual field defect secondary to optic perineuritis. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000206DOI Listing
January 2019
4 Reads

Response to comment on: Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema.

Indian J Ophthalmol 2019 01;67(1):177-178

Neuro-Ophthalmology Services, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, L.V. Prasad Marg, Banjara Hills, Hyderabad, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_1771_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324107PMC
January 2019
1 Read

Comment on: Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema.

Indian J Ophthalmol 2019 01;67(1):176-177

Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1091, USA.

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http://dx.doi.org/10.4103/ijo.IJO_1308_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324111PMC
January 2019
1 Read

Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation.

Indian J Ophthalmol 2019 Jan;67(1):142

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijo.IJO_881_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324127PMC
January 2019
6 Reads

Optic nerve head width and retinal nerve fiber layer changes are proper indexes for validating the successful induction of experimental anterior ischemic optic neuropathy.

Exp Eye Res 2019 Apr 15;181:105-111. Epub 2018 Dec 15.

Institute of Eye Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Reproducible skills are essential for successful induction of a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by measuring the natural course of optic nerve head (ONH) width and retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. Read More

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http://dx.doi.org/10.1016/j.exer.2018.12.007DOI Listing
April 2019
4 Reads

Simultaneous bilateral posterior ischemic optic neuropathy secondary to giant cell arteritis: a case presentation and review of the literature.

BMC Ophthalmol 2018 Dec 12;18(1):317. Epub 2018 Dec 12.

Neurology division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia of the anterior portion of the optic nerve, and less frequently simultaneous.

Case Presentation: An 80-year-old Saudi male came with a history of simultaneous bilateral vision loss 5 days prior to presentation. Read More

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http://dx.doi.org/10.1186/s12886-018-0994-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292061PMC
December 2018
3 Reads

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma.

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000722DOI Listing
October 2018
23 Reads

Ischemic optic neuropathy in robotic-assisted gynaecologic surgery: A case report.

J Obstet Gynaecol Res 2019 Mar 6;45(3):748-750. Epub 2018 Dec 6.

Ceyhan State Hospital Ophthalmology Department, Adana, Turkey.

The study was aimed to present a rare case of who developed non arteritic anterior ischemic optic neuropathy (NAION) following robotic-assisted gynaecologic surgery. A 58-year-old female patient presented with vision loss in right eye after non-complicated robotic-assisted total hysterectomy and bilateral salpingo-oopherectomy. We observed on fundoscopy optic disc edema and splinter hemorrhages at the optic disc edges. Read More

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http://doi.wiley.com/10.1111/jog.13877
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http://dx.doi.org/10.1111/jog.13877DOI Listing
March 2019
19 Reads

Non-arteritic anterior ischemic optic neuropathy - Case report.

Rom J Ophthalmol 2018 Jul-Sep;62(3):231-245

"Prof. Dr. Agrippa Ionescu" Clinical Emergency Hospital, Bucharest, Romania.

We present a case of Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION) with uncertain etiology but a good recovery with a total gain of central visual acuity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256078PMC
February 2019
1 Read

A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin.

BMC Ophthalmol 2018 Nov 22;18(1):304. Epub 2018 Nov 22.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, NO.100, Haining Road, Hongkou District, Shanghai, 200080, China.

Background: A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further investigated.

Methods: Photodynamic treatment was conducted on the optic nerve head (ONH) following administration of the photosensitizer. Read More

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http://dx.doi.org/10.1186/s12886-018-0937-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251118PMC
November 2018
13 Reads

New concepts on acute ocular ischemia.

Curr Opin Neurol 2019 Feb;32(1):19-24

Department of Ophthalmology.

Purpose Of Review: To review recent advances in the management of acute ocular ischemic events, including: transient monocular vision loss, central and branch retinal artery occlusions, and nonarteritic anterior ischemic optic neuropathy.

Recent Findings: Transient monocular vision loss and acute retinal arterial occlusions require immediate diagnosis and management, with recognition of these events as transient ischemic attack or stroke equivalents, respectively. Patients should undergo an immediate stroke workup in a stroke center, similar to patients with acute cerebral ischemia. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000634DOI Listing
February 2019
20 Reads

Sequential nonarteritic anterior ischemic optic neuropathy in patient on chronic hemodialysis.

CEN Case Rep 2019 May 21;8(2):89-94. Epub 2018 Nov 21.

University of Toronto, Department of Ophthalmology and Vision Sciences, 801 Eglinton Ave West Suite 301, Toronto, ON, M5N 1E3, Canada.

Nonarteritic anterior ischemic optic neuropathy (NAION) is a well acknowledged rare complication of chronic hemodialysis in patients with end-stage renal disease (ESRD). We present a unique case of a patient on chronic hemodialysis who presented with an NAION in the right eye, then 3 months later developed an NAION in the left eye followed in 1 month by second NAION episode in the left eye. Every episode of NAION was accompanied by intradialytic hypotension (drop in systolic blood pressure of over 20 mmHg) where visual loss was noticed at the end of the dialysis session. Read More

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http://dx.doi.org/10.1007/s13730-018-0372-8DOI Listing
May 2019
13 Reads

Update on obstructive sleep apnea for neuro-ophthalmology.

Authors:
Clare L Fraser

Curr Opin Neurol 2019 Feb;32(1):124-130

Save Sight Institute, The University of Sydney.

Purpose Of Review: Obstructive sleep apnea (OSA) is increasing in prevalence. The intermittent hypoxia of OSA has wide-ranging effects on a patient's general health outcomes. However, gold-standard investigations and treatment are expensive and a significant burden on patients. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000630DOI Listing
February 2019
4 Reads

Obstructive sleep apnoea and increased risk of non-arteritic anterior ischaemic optic neuropathy.

Br J Ophthalmol 2018 Nov 9. Epub 2018 Nov 9.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background/aims: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population.

Methods: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3129
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http://dx.doi.org/10.1136/bjophthalmol-2018-312910DOI Listing
November 2018
12 Reads

Giant cell arteritis presenting as bilateral anterior ischemic optic neuropathy: a biopsy-proven case report in Chinese patient.

BMC Ophthalmol 2018 Oct 30;18(1):282. Epub 2018 Oct 30.

Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: Giant cell arteritis (GCA) is a systemic vasculitis of medium and large-size vessels and can led to permanent visual loss in elderly patients. GCA is very rare among Asians. We report a Chinese patient presenting with acute bilateral anterior ischemic optic neuropathy, and the temporal artery biopsy proved the diagnose of GCA. Read More

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http://dx.doi.org/10.1186/s12886-018-0953-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208180PMC
October 2018
5 Reads
1.075 Impact Factor

Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis.

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0949-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203970PMC
October 2018
9 Reads

Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots.

Aerosp Med Hum Perform 2018 Nov;89(11):1005-1007

Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic neuropathy with the exact pathophysiology unknown. Risk factors include advanced age, small optic nerve head, hypertension, diabetes mellitus, and sleep apnea. High altitude is considered another risk factor, although only few cases have been reported. Read More

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http://www.ingentaconnect.com/content/10.3357/AMHP.5177.2018
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http://dx.doi.org/10.3357/AMHP.5177.2018DOI Listing
November 2018
45 Reads

Risk Factors for Fellow Eye Involvement in Nonarteritic Anterior Ischemic Optic Neuropathy.

J Neuroophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals older than 50 years. Demographic, ocular, and systemic risk factors for NAION have been identified, and we sought to determine which, if any, of these factors also increase risk of NAION in the fellow eye.

Methods: We performed a retrospective chart review of patients with "ischemic optic neuropathy" (based on International Classification of Disease [ICD] codes) seen at a single eye center between 2007 and 2017. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000715DOI Listing
October 2018
2 Reads

Obstructive Sleep Apnea in Neuro-Ophthalmology.

J Neuroophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Save Sight Institute, Discipline of Ophthalmology, Faculty of Medicine and Health Sciences, University of Sydney, Sydney, Australia; Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Obstructive sleep apnea (OSA) is a common pulmonary disorder with many systemic sequelae. Its association with diseases seen in neuro-ophthalmology is being increasingly recognized. Treatment of OSA with continuous positive airway pressure (CPAP) may reverse the pathology in some eye diseases. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000728DOI Listing
October 2018
4 Reads
1.810 Impact Factor

A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy.

Curr Eye Res 2018 Dec 1;43(12):1489-1499. Epub 2018 Oct 1.

a Departments of Ophthalmology , Stanford University School of Medicine , Stanford , CA , USA.

Purpose: Brain-derived neurotrophic factor (BDNF) and activation of its high affinity receptor tropomyosin kinase (Trk) B promote retinal ganglion cells (RGCs) survival following injury. In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years.

Methods: We assessed drug effects on immunopanned, cultured RGCs and calculated RGC survival and assessed TrkB receptor activation by mitogen-activated protein (MAP) kinase translocation. Read More

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http://dx.doi.org/10.1080/02713683.2018.1508726DOI Listing
December 2018
3 Reads

Early Macular Vessel Density Loss in Acute Ischemic Optic Neuropathy Compared to Papilledema: Implications for Pathogenesis.

Transl Vis Sci Technol 2018 Sep 26;7(5):10. Epub 2018 Sep 26.

Department of Ophthalmology, University of Colorado, School of Medicine, Aurora, CO, USA.

Purpose: This study compares macular and parafoveal vasculature in patients with optic disc swelling.

Methods: Twenty eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 39 eyes with papilledema at first presentation, and 22 eyes of normal subjects were imaged using optical coherence tomography angiography (OCT-A). Macular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer thicknesses were measured in addition to macula and parafovea superficial and deep vasculature. Read More

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http://tvst.arvojournals.org/article.aspx?doi=10.1167/tvst.7
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http://dx.doi.org/10.1167/tvst.7.5.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159734PMC
September 2018
11 Reads

Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type?

Neuroophthalmology 2018 Oct 9;42(5):287-294. Epub 2018 Jan 9.

Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

The aim of this study was to assess the possible relationship between AAION (arteritic anterior ischemic optic neuropathy) and NAION (non-arteritic anterior ischemic optic neuropathy) with blood platelet parameters and NLR (neutrophil-to-lymphocyte ratio). The medical records of 12 patients with AAION, 33 patients with NAION, and 35 healthy subjects were examined. MPV, PDW, and PCT values showed marked elevation in AAION and NAION groups compared with control group. Read More

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http://dx.doi.org/10.1080/01658107.2017.1405995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152540PMC
October 2018
3 Reads

Systemic-Related Factors of Nonarteritic Anterior Ischemic Optic Neuropathy.

Chin Med J (Engl) 2018 10;131(19):2357-2359

Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei 063000, China.

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http://dx.doi.org/10.4103/0366-6999.241795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166455PMC
October 2018
2 Reads

Optic nerve head morphology in primary open-angle glaucoma and nonarteritic anterior ischaemic optic neuropathy measured with spectral domain optical coherence tomography.

Acta Ophthalmol 2018 Dec 21;96(8):e1018-e1024. Epub 2018 Sep 21.

Department of Ophthalmology and Optometry, Medical University Vienna, Vienna, Austria.

Purpose: Optic nerve head (ONH) parameters as well as circumpapillary retinal nerve fibre layer (RNFL) thickness values measured with two different spectral domain optical coherence tomography (SD-OCT) machines (Spectralis and Cirrus OCT) have been compared between two patient groups, primary open-angle glaucoma (POAG), nonarteritic anterior ischaemic optic neuropathy (NAION) and healthy controls. A comparison of the performance of the two OCT machines was made.

Methods: Twenty healthy controls, 20 POAG and 20 NAION patients with comparable visual field defects were included. Read More

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http://dx.doi.org/10.1111/aos.13804DOI Listing
December 2018
1 Read

Positron emission tomography and reframing vasculitis as a spectrum of disease when investigating a patient with a fever of unknown origin.

BMJ Case Rep 2018 Sep 19;2018. Epub 2018 Sep 19.

Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.

A retired businessman presented to the infectious diseases department with a history of ongoing fevers and myalgia and raised inflammatory markers. This continued despite adequate antibiotic treatment of an epididymo-orchitis. Extensive investigations, including bone marrow and liver biopsies and a positron emission tomography, did not reveal a cause but showed reactive change in the bone marrow. Read More

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http://dx.doi.org/10.1136/bcr-2018-224540DOI Listing
September 2018
5 Reads

Anterior Ischemic Optic Neuropathy in a Patient with Erectile Dysfunction: Tadalafil as an Offending Medication.

J Res Pharm Pract 2018 Jul-Sep;7(3):164-167

Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Erectile dysfunction (ED) has negative effects on quality of life. The first line of oral medication for this condition is phosphodiesterase type 5 inhibitors (PDE5I) including Tadalafil. Ocular complications associated with Tadalafil are rare and usually occurred in participant with known risk factors. Read More

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http://dx.doi.org/10.4103/jrpp.JRPP_18_29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121764PMC
September 2018
1 Read