Search Our Scientific Publications & Authors

Ophthalmologe 2021 Jun 4. Epub 2021 Jun 4.

Commission for Cross-Sectoral Ophthalmology of the DOG (German Ophthalmological Society e. V.) and BVA (Professional Association of German Ophthalmologists), Munich/Düsseldorf, Germany.

Background: Survey by the commission for cross-sectoral ophthalmology, as a joint commission of the German Ophthalmological Society (DOG) and the Professional Association of German Ophthalmologists (BVA) on the effects of the SARS-CoV‑2 pandemic on ophthalmological patient care in Germany.

Methods: Online-based survey.

Results: A total of 1190 questionnaires were (partly) answered. Read More

Rev Clin Esp (Barc) 2021 May 28. Epub 2021 May 28.

Servicio de Medicina Interna, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, San Sebastián de los Reyes, Madrid, Spain.

Ocular vascular problems represent an emerging pathology within the activity of the internist. Ocular ultrasound is a widely used technique to evaluate a variety of eye conditions. Specifically, Doppler ultrasound of the ophthalmic vessels has become a very useful tool in diagnosing various eye diseases. Read More

J Fr Ophtalmol 2021 Jun 27;44(6):777-785. Epub 2021 May 27.

Department of Ophthalmology, Reims University Hospital, Reims, France; Université Reims Champagne Ardennes, URCA, Reims, France.

Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of vision loss but no treatment has demonstrated its efficiency. A preliminary study showed an improvement on the visual acuity (VA) in a group of patients who received intravitreal administration of triamcinolone acetonide (IVTA) versus a non-treated group. In the present series, the visual outcome of IVTA in NAION was evaluated on a larger group of patients. Read More

J Neuroophthalmol 2021 Apr 26. Epub 2021 Apr 26.

Departments of Ophthalmology and Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota Departments of Ophthalmology and Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.

J Neuroophthalmol 2021 Apr 26. Epub 2021 Apr 26.

Tufts University School of Medicine (AMM, VP, TRH, LT, LNV), Boston, Massachusetts; New England Eye Center (TRH, LNV), Tufts New England Medical Center, Boston, Massachusetts; and Department of Neurology (TRH), Tufts New England Medical Center, Boston, Massachusetts.

Background: Although nonarteritic anterior ischemic optic neuropathy (NAION) is considered a disorder that primarily affects the optic nerve head, optical coherence tomography (OCT) shows peripapillary and foveal subretinal fluid associated with optic disc swelling from NAION. We sought to further evaluate retinal and vitreous changes in patients with NAION.

Methods: Patients diagnosed with NAION at the New England Eye Center between 2013 and 2017 were evaluated using OCT. Read More

J Neuroophthalmol 2021 06;41(2):166-169

Klinik Landstrasse (JF), Messerli Institute, Vienna, Austria; Disciplina de Neurociência (FAS, CASC), Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, Brazil; Programa de Estudos Pós-Graduado em Fonoaudiologia (ACF), Pontifícia Universidade Católica de São Paulo (PUC-SP), São Paulo, Brazil; and Departamento de Fonoaudiologia (ACF), Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil.

Objectives: Affection of the central nervous system and the eyes is increasingly recognized as manifestations of a SARS-CoV-2 infection (COVID-19). This review aims at summarizing and discussing recent advances concerning causes and locations of impaired vision because of an infection with SARS-CoV-2.

Methods: On a literature search through PubMed and ScholarOne, all available publications about COVID-19 patients with impaired vision were retrieved. Read More

Curr Eye Res 2021 May 24:1-10. Epub 2021 May 24.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

: To compare the optic nerve head (ONH) structure and microvasculature in patients with optic atrophy due to non-arteritic anterior ischemic optic neuropathy (NAION), compressive optic neuropathy (CON), methanol-induced optic neuropathy (MION), and traumatic optic neuropathy (TON) using optical coherence tomography angiography.: In this comparative, cross-sectional study, 32 eyes with NAION, 18 eyes with CON, 32 eyes with MION, 23 eyes with TON, and 55 normal eyes were enrolled. Radial peripapillary capillary (RPC) vessel density, peripapillary retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, and cup/disc area ratio were obtained using the RTVue XR Avanti system (Optovue Inc. Read More

Quant Imaging Med Surg 2021 May;11(5):1932-1945

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) patients experience hypo-perfusion in the short posterior ciliary arteries (SPCAs), however, the cause of hypo-perfusion is unclear. Real-time dynamic hemodynamic observations may provide clues into specific NAION pathogenic mechanisms. We aim to analyze hemodynamic changes occurring in NAION using multimodality imaging. Read More

Photodiagnosis Photodyn Ther 2021 Apr 27;34:102299. Epub 2021 Apr 27.

Erciyes University Faculty of Medicine, Department of Ophthalmology, Kayseri, Turkey.

Introduction: Polyarteritis nodosa is a systemic vasculitis characterized by necrotizing inflammatory lesions affecting the middle and small arteries.

Case Presentation: A 23-year-old male presented to our ophthalmology clinic with a 1-day history of sudden vision loss in his left eye. Posterior segment examination the left eye showed optic disc borders were faint, hyperemic and fluffy with cilioretinal artery occlusion signs present. Read More

Scars Burn Heal 2021 Jan-Dec;7:20595131211006659. Epub 2021 Apr 14.

Burn Center, Department of Plastic- and Maxillofacial Surgery, Uppsala University Hospital, Uppsala, Sweden.

Introduction: Ophthalmological complications such as orbital compartment syndrome (OCS) and ischemic optic neuropathy are rare complications in patients with burns and have been described in patients where aggressive fluid resuscitation was performed. While OCS requires urgent surgical intervention, no current treatment is established to treat, or prevent, ischemic optic neuropathy in patients with burns.

Methods: The authors report a case of a 38-year-old woman with flame burns including the periorbital regions who developed OCS on the left side and anterior ischemic optic neuropathy (AION) on the right side despite non-aggressive fluid resuscitation. Read More

Int J Ophthalmol 2021 18;14(4):517-522. Epub 2021 Apr 18.

Neuro Ophthalmology Unit, Ophthalmology Department, Rabin Medical Center, Petah Tikva 4941492, Israel.

Aim: To study whether patients with progressive nonarteritic anterior ischemic optic neuropathy (NAION) present earlier than patients with stable NAION and to describe their clinical characteristics and visual outcome.

Methods: This was a retrospective chart review. All patients with NAION seen during the acute stage from January 2012 to December 2018 were reviewed. Read More

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Department of Ophthalmology (SP, YY, YJL), Stanford University School of Medicine, Stanford, California; Department of Ophthalmology (YY), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; and Department of Neurology (YJL), Stanford University School of Medicine, Stanford, California.

Int J Med Sci 2021 27;18(10):2239-2244. Epub 2021 Mar 27.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

To assess the role of complete blood cell count (CBC) dimensional indices and CBC-derived measures in non-arteritic anterior ischemic optic neuropathy (NA-AION). In this retrospective case-control survey, 37 newly diagnosed NA-AION patients and 37 sex- and age-matched cataract controls were enrolled in 2017-2018. On the same day of NA-AION diagnosis, a blood sample was collected and CBC was determined using an automatic blood counter. Read More

Ann Transl Med 2021 Mar;9(6):451

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: The ophthalmic artery (OA) was first reconstructed using computer software. The structural differences of ophthalmic arteries in non-arteritic anterior ischemic optic neuropathy (NAION) and normal eyes, in addition to hemodynamic alterations, were assessed.

Methods: Thirty-one NAION eyes, 19 uninvolved eyes with NAION, and a control group of 26 healthy eyes were retrospectively included. Read More

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):546-551. Epub 2021 Jan 18.

Department of Anaesthesia, Rajiv Gandhi Cancer Institute and Research Centre, Sec-5, Rohini, New Delhi, India.

Background And Aims: Raised intraocular pressure (IOP) is one of the known causes of anterior ischemic optic neuropathy. In the case of robotic urological-gynecological surgeries, patient is kept in steep Trendelenburg supine-lithotomy position. Aim of this study was to observe the quantitative rise in IOP in steep Trendelenburg position (>45°) in robotic-assisted prostatectomy and hysterectomy. Read More

Int Ophthalmol 2021 Apr 5. Epub 2021 Apr 5.

Ophthalmology, Pamukkale University, Denizli, Turkey.

Purpose: To show alterations of retinal arteriolar caliber (RAC), retinal venular caliber (RVC), retinal nerve fiber layer thickness (RNFLT), peripapillary choroidal thickness (ppCT), and central macular thickness (CMT) in acute and chronic phases of nonarteritic anterior ischemic optic neuropathy (NAION).

Methods: Forty-one eyes of 41 patients with NAION were included in this retrospective study. RAC, RVC, RNFLT, ppCT, and CMT measurements were performed via spectral-domain optical coherence tomography in the acute and chronic phases of NAION. Read More

Pharmaceuticals (Basel) 2021 Mar 20;14(3). Epub 2021 Mar 20.

IRCCS-Fondazione Bietti, Via Livenza, 3, 00198 Rome, Italy.

Cytidine 5'-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its multifactorial mechanism of action and the involvement in several metabolic pathways, including phospholipid homeostasis, mitochondrial dynamics, as well as cholinergic and dopaminergic transmission, all being involved in the complexity of the visual transmission. This narrative review is aimed at reporting both pre-clinical data regarding the involvement of citicoline in such metabolic pathways (including new insights about its role in the intracellular proteostasis through an interaction with the proteasome) and its effects on clinical psychophysical, electrophysiological, and morphological outcomes following its use in ophthalmological neurodegenerative diseases (including the results of the most recent prospective randomized clinical trials). Read More

J Clin Med 2021 Mar 10;10(6). Epub 2021 Mar 10.

Division of Vascular Medicine, Medical Clinic and Policlinic IV, Hospital of the Ludwig-Maximilians-University, 80336 Munich, Germany.

Background: Risk stratification based on pre-test probability may improve the diagnostic accuracy of temporal artery high-resolution compression sonography (hrTCS) in the diagnostic workup of cranial giant cell arteritis (cGCA).

Methods: A logistic regression model with candidate items was derived from a cohort of patients with suspected cGCA ( = 87). The diagnostic accuracy of the model was tested in the derivation cohort and in an independent validation cohort ( = 114) by receiver operator characteristics (ROC) analysis. Read More

PLoS One 2021 25;16(3):e0243186. Epub 2021 Mar 25.

Department of Ophthalmology and Visual Sciences, University of Maryland at Baltimore (UMB), Baltimore, Maryland, United States of America.

The rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION) is similar in many of its pathophysiological responses to clinical NAION. Like human NAION, there is significant variability in the severity of the lesion produced, and little is known of the parameters associated with rNAION induction severity or if pre- or early post-induction biomarkers can be identified that enable prediction of lesion severity and ultimate loss of retinal ganglion cells (RGCs). Adult male Sprague-Dawley outbred rats were evaluated for various parameters including physiological characteristics (heart rate, respiratory rate, temperature, hematocrit [Hct]), optic nerve head (ONH) appearance, pre- and post-induction mean diameter, and intravenous fluorescein and indocyanine green angiographic patterns of vascular leakage at 5 hours post-induction, performed using a spectral domain-optical coherence tomography (SD-OCT) instrument. Read More

Arthritis Res Ther 2021 03 22;23(1):92. Epub 2021 Mar 22.

Department of Rheumatology, Immunology and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objectives: Giant cell arteritis (GCA) may lead to vision loss. To what extent tocilizumab (TCZ) is able to prevent vision loss is unknown. The aim was to analyze the occurrence of vision loss in a large GCA cohort treated with TCZ. Read More

J Fr Ophtalmol 2021 Apr 10;44(4):481-484. Epub 2021 Mar 10.

Department of internal medicine, Fondation Adolphe-de-Rothschild hospital, Paris, France.

Purpose: To report the case of a patient with arteritic anterior ischemic optic neuropathy (AAION) with a history of glucocorticoids (GC) hypersensitivity treated with monthly intravenous tocilizumab (IV TCZ) and short course of GC.

Case Report: A 71-year-old Caucasian patient presented with AAION related to giant cell arteritis (GCA) confirmed by temporal artery biopsy. Past medical history was significant for GC hypersensitivity proven by allergy evaluation and the patient was managed with IV TCZ and very short-course GC. Read More

Semin Ophthalmol 2021 Mar 10:1-9. Epub 2021 Mar 10.

Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Science, Tehran, Iran.

To investigate the efficacy of intravitreal injection of granulocyte colony-stimulating factor (G-CSF) for the treatment of non-arteritic anterior ischemic optic neuropathy (NAION). Patients with acute NAION were enrolled in this prospective interventional case series. They received an intravitreal injection of 60 micrograms in 0. Read More

Int J Mol Sci 2021 Feb 20;22(4). Epub 2021 Feb 20.

Institute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Mesenchymal stem cell (MSC) therapy has been investigated intensively for many years. However, there is a potential risk related to MSC applications in various cell niches.

Methods: The safety of intravitreal MSC application and the efficacy of MSC-derived conditioned medium (MDCM) were evaluated in the normal eye and the diseased eye, respectively. Read More

Curr Eye Res 2021 Mar 12:1-2. Epub 2021 Mar 12.

Pontifícia Universidade Católica de São Paulo (PUC-SP), Sao Paolo, Brazil.

Ophthalmologic nvolvement in SARS-CoV-infected patients is variegated. One of the ophthalmologic pathologies is optic neuritis. Optic neuritis in SARS-CoV-infected patients may precede the classical pulmonary manifestations of COVID-19 and can be unilateral or bilateral. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Mar 4. Epub 2021 Mar 4.

Department of Ophthalmology, Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey.

Purpose: This cross-sectional study compared the peripapillary vessel density (VD), peripapillary retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters between eyes with atrophic non-arteritic anterior ischemic optic neuropathy (NAION) and eyes with advanced primary open-angle glaucoma (POAG) matched for visual field mean deviation.

Methods: Peripapillary VDs and RNFL thicknesses in the peripapillary region, and 4 sectors (superior, inferior, nasal, and temporal), and scanning laser ophthalmoscopy parameters of the ONH were evaluated with optical coherence tomography angiography (OCTA) among 21 atrophic NAION cases, 26 advanced POAG cases, and 30 age- and sex-matched healthy controls.

Results: The POAG eyes had lower peripapillary VDs in all areas compared with the NAION eyes, which was most marked in the inferior and nasal sectors (p=0. Read More

Invest Ophthalmol Vis Sci 2021 Feb;62(2):42

Department of Ophthalmology III, Quinze-Vingts Hospital, IHU FOReSIGHT, Paris, France.

Purpose: The purpose of this study was to describe capillary changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography-angiography (OCT-A) and correlate the results with best corrected visual acuity (BCVA), visual field, OCT retinal nerve fiber layer (RNFL), and combined thickness of ganglion cell and inner plexiform layers (GCIPL) thicknesses.

Methods: We enrolled 22 eyes with acute NAION and 30 normal control (NC) subjects in this study. Whole en face image vessel density (WiVD) was measured in the radial peripapillary capillary plexus (RPC), superficial capillary plexus (SCP), and deep vascular complex (DVC) using OCT-A. Read More

Optom Vis Sci 2021 03;98(3):212-216

Significance: This case highlights ocular ischemia after hemodialysis resulting in permanent vision loss. Fifteen percent of the U.S. Read More

J Neuroophthalmol 2021 02 19. Epub 2021 Feb 19.

Department of Clinical Neurological Sciences and Department of Ophthalmology (JAF), Western University, London, Canada; Department of Ophthalmology (PAS), State University of New York at Stony Brook, Stony Brook, New York; Moorfields Eye Hospital (AP), London, United Kingdom; Department of Neurology (AP), Amsterdam Neuroscience, VUmc MS Center Amsterdam and Dutch Expertise Centre for Neuro-ophthalmology, VU University Medical Centre, Amsterdam, The Netherlands; Institute of Neurology (AP), University College London, London, United Kingdom; Department of Eye Pathology (CT), UCL Institute of Ophthalmology, London, United Kingdom; Moorfields Eye Hospital (CT), London, United Kingdom; and Department of Ophthalmology (SH), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: With the development and widespread adoption of spectral-domain optical coherence tomography (OCT), peripapillary hyper-reflective ovoid mass-like structures (PHOMS) have become a frequent OCT finding in neuro-ophthalmic practice. Although originally assumed to represent a form of buried optic disc drusen (ODD), PHOMS differ from ODD in many important ways. The histopathological underpinnings of PHOMS are now becoming more clearly understood. Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):11-15. Epub 2021 Jan 7.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

A 61-year-old woman presented with sudden vision loss from a left anterior optic neuropathy in the context of severely elevated intraocular pressure after starting topical steroids for anterior uveitis related to herpes zoster ophthalmicus (HZO). The strong temporal relationship between the vision loss and elevated IOP suggested the vision loss was related to nonarteritic anterior ischemic optic neuropathy (NAION). Anterior chamber paracentesis did not detect varicella zoster virus (VZV) and magnetic resonance imaging of the orbits was normal. Read More

Korean J Ophthalmol 2021 04 18;35(2):168-170. Epub 2021 Feb 18.

Department of Ophthalmology, Gyeongsang National University Hospital, College of Medicine, Gyeongsang National University, Jinju, Korea.