1,462 results match your criteria Optic Neuropathy Anterior Ischemic


Optic nerve head width and retinal nerve fiber layer changes are good indexes for validating the successful induction of experimental anterior ischemic optic neuropathy.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Eye Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Reproducible skills are essential for successful induction of a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by measuring the natural course of optic nerve head (ONH) width and retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. Read More

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http://dx.doi.org/10.1016/j.exer.2018.12.007DOI Listing
December 2018

Simultaneous bilateral posterior ischemic optic neuropathy secondary to giant cell arteritis: a case presentation and review of the literature.

BMC Ophthalmol 2018 Dec 12;18(1):317. Epub 2018 Dec 12.

Neurology division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia of the anterior portion of the optic nerve, and less frequently simultaneous.

Case Presentation: An 80-year-old Saudi male came with a history of simultaneous bilateral vision loss 5 days prior to presentation. Read More

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http://dx.doi.org/10.1186/s12886-018-0994-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292061PMC
December 2018

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma.

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000722DOI Listing
October 2018
2 Reads

Ischemic optic neuropathy in robotic-assisted gynaecologic surgery: A case report.

J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.

Ceyhan State Hospital Ophthalmology Department, Adana, Turkey.

The study was aimed to present a rare case of who developed non arteritic anterior ischemic optic neuropathy (NAION) following robotic-assisted gynaecologic surgery. A 58-year-old female patient presented with vision loss in right eye after non-complicated robotic-assisted total hysterectomy and bilateral salpingo-oopherectomy. We observed on fundoscopy optic disc edema and splinter hemorrhages at the optic disc edges. Read More

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http://doi.wiley.com/10.1111/jog.13877
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http://dx.doi.org/10.1111/jog.13877DOI Listing
December 2018
6 Reads

Non-arteritic anterior ischemic optic neuropathy - Case report.

Rom J Ophthalmol 2018 Jul-Sep;62(3):231-245

"Prof. Dr. Agrippa Ionescu" Clinical Emergency Hospital, Bucharest, Romania.

We present a case of Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION) with uncertain etiology but a good recovery with a total gain of central visual acuity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256078PMC
December 2018
1 Read

A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin.

BMC Ophthalmol 2018 Nov 22;18(1):304. Epub 2018 Nov 22.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, NO.100, Haining Road, Hongkou District, Shanghai, 200080, China.

Background: A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further investigated.

Methods: Photodynamic treatment was conducted on the optic nerve head (ONH) following administration of the photosensitizer. Read More

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http://dx.doi.org/10.1186/s12886-018-0937-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251118PMC
November 2018
2 Reads

New concepts on acute ocular ischemia.

Curr Opin Neurol 2019 Feb;32(1):19-24

Department of Ophthalmology.

Purpose Of Review: To review recent advances in the management of acute ocular ischemic events, including: transient monocular vision loss, central and branch retinal artery occlusions, and nonarteritic anterior ischemic optic neuropathy.

Recent Findings: Transient monocular vision loss and acute retinal arterial occlusions require immediate diagnosis and management, with recognition of these events as transient ischemic attack or stroke equivalents, respectively. Patients should undergo an immediate stroke workup in a stroke center, similar to patients with acute cerebral ischemia. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000634DOI Listing
February 2019
2 Reads

Sequential nonarteritic anterior ischemic optic neuropathy in patient on chronic hemodialysis.

CEN Case Rep 2018 Nov 21. Epub 2018 Nov 21.

University of Toronto, Department of Ophthalmology and Vision Sciences, 801 Eglinton Ave West Suite 301, Toronto, ON, M5N 1E3, Canada.

Nonarteritic anterior ischemic optic neuropathy (NAION) is a well acknowledged rare complication of chronic hemodialysis in patients with end-stage renal disease (ESRD). We present a unique case of a patient on chronic hemodialysis who presented with an NAION in the right eye, then 3 months later developed an NAION in the left eye followed in 1 month by second NAION episode in the left eye. Every episode of NAION was accompanied by intradialytic hypotension (drop in systolic blood pressure of over 20 mmHg) where visual loss was noticed at the end of the dialysis session. Read More

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http://dx.doi.org/10.1007/s13730-018-0372-8DOI Listing
November 2018
4 Reads

Update on obstructive sleep apnea for neuro-ophthalmology.

Authors:
Clare L Fraser

Curr Opin Neurol 2019 Feb;32(1):124-130

Save Sight Institute, The University of Sydney.

Purpose Of Review: Obstructive sleep apnea (OSA) is increasing in prevalence. The intermittent hypoxia of OSA has wide-ranging effects on a patient's general health outcomes. However, gold-standard investigations and treatment are expensive and a significant burden on patients. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000630DOI Listing
February 2019
3 Reads

Obstructive sleep apnoea and increased risk of non-arteritic anterior ischaemic optic neuropathy.

Br J Ophthalmol 2018 Nov 9. Epub 2018 Nov 9.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background/aims: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population.

Methods: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3129
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http://dx.doi.org/10.1136/bjophthalmol-2018-312910DOI Listing
November 2018
3 Reads

Giant cell arteritis presenting as bilateral anterior ischemic optic neuropathy: a biopsy-proven case report in Chinese patient.

BMC Ophthalmol 2018 Oct 30;18(1):282. Epub 2018 Oct 30.

Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: Giant cell arteritis (GCA) is a systemic vasculitis of medium and large-size vessels and can led to permanent visual loss in elderly patients. GCA is very rare among Asians. We report a Chinese patient presenting with acute bilateral anterior ischemic optic neuropathy, and the temporal artery biopsy proved the diagnose of GCA. Read More

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http://dx.doi.org/10.1186/s12886-018-0953-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208180PMC
October 2018
1 Read
1.075 Impact Factor

Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis.

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0949-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203970PMC
October 2018
7 Reads

Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots.

Aerosp Med Hum Perform 2018 Nov;89(11):1005-1007

Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic neuropathy with the exact pathophysiology unknown. Risk factors include advanced age, small optic nerve head, hypertension, diabetes mellitus, and sleep apnea. High altitude is considered another risk factor, although only few cases have been reported. Read More

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http://www.ingentaconnect.com/content/10.3357/AMHP.5177.2018
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http://dx.doi.org/10.3357/AMHP.5177.2018DOI Listing
November 2018
38 Reads

Risk Factors for Fellow Eye Involvement in Nonarteritic Anterior Ischemic Optic Neuropathy.

J Neuroophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals older than 50 years. Demographic, ocular, and systemic risk factors for NAION have been identified, and we sought to determine which, if any, of these factors also increase risk of NAION in the fellow eye.

Methods: We performed a retrospective chart review of patients with "ischemic optic neuropathy" (based on International Classification of Disease [ICD] codes) seen at a single eye center between 2007 and 2017. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000715DOI Listing
October 2018
2 Reads

Obstructive Sleep Apnea in Neuro-Ophthalmology.

J Neuroophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Save Sight Institute, Discipline of Ophthalmology, Faculty of Medicine and Health Sciences, University of Sydney, Sydney, Australia; Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Obstructive sleep apnea (OSA) is a common pulmonary disorder with many systemic sequelae. Its association with diseases seen in neuro-ophthalmology is being increasingly recognized. Treatment of OSA with continuous positive airway pressure (CPAP) may reverse the pathology in some eye diseases. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000728DOI Listing
October 2018
2 Reads
1.810 Impact Factor

A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy.

Curr Eye Res 2018 Dec 1;43(12):1489-1499. Epub 2018 Oct 1.

a Departments of Ophthalmology , Stanford University School of Medicine , Stanford , CA , USA.

Purpose: Brain-derived neurotrophic factor (BDNF) and activation of its high affinity receptor tropomyosin kinase (Trk) B promote retinal ganglion cells (RGCs) survival following injury. In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years.

Methods: We assessed drug effects on immunopanned, cultured RGCs and calculated RGC survival and assessed TrkB receptor activation by mitogen-activated protein (MAP) kinase translocation. Read More

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http://dx.doi.org/10.1080/02713683.2018.1508726DOI Listing
December 2018
2 Reads

Early Macular Vessel Density Loss in Acute Ischemic Optic Neuropathy Compared to Papilledema: Implications for Pathogenesis.

Transl Vis Sci Technol 2018 Sep 26;7(5):10. Epub 2018 Sep 26.

Department of Ophthalmology, University of Colorado, School of Medicine, Aurora, CO, USA.

Purpose: This study compares macular and parafoveal vasculature in patients with optic disc swelling.

Methods: Twenty eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 39 eyes with papilledema at first presentation, and 22 eyes of normal subjects were imaged using optical coherence tomography angiography (OCT-A). Macular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer thicknesses were measured in addition to macula and parafovea superficial and deep vasculature. Read More

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http://tvst.arvojournals.org/article.aspx?doi=10.1167/tvst.7
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http://dx.doi.org/10.1167/tvst.7.5.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159734PMC
September 2018
8 Reads

Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type?

Neuroophthalmology 2018 Oct 9;42(5):287-294. Epub 2018 Jan 9.

Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

The aim of this study was to assess the possible relationship between AAION (arteritic anterior ischemic optic neuropathy) and NAION (non-arteritic anterior ischemic optic neuropathy) with blood platelet parameters and NLR (neutrophil-to-lymphocyte ratio). The medical records of 12 patients with AAION, 33 patients with NAION, and 35 healthy subjects were examined. MPV, PDW, and PCT values showed marked elevation in AAION and NAION groups compared with control group. Read More

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http://dx.doi.org/10.1080/01658107.2017.1405995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152540PMC
October 2018
1 Read

Systemic-Related Factors of Nonarteritic Anterior Ischemic Optic Neuropathy.

Chin Med J (Engl) 2018 Oct;131(19):2357-2359

Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei 063000, China.

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http://dx.doi.org/10.4103/0366-6999.241795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166455PMC
October 2018
1 Read

Anterior Ischemic Optic Neuropathy in a Patient with Erectile Dysfunction: Tadalafil as an Offending Medication.

J Res Pharm Pract 2018 Jul-Sep;7(3):164-167

Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Erectile dysfunction (ED) has negative effects on quality of life. The first line of oral medication for this condition is phosphodiesterase type 5 inhibitors (PDE5I) including Tadalafil. Ocular complications associated with Tadalafil are rare and usually occurred in participant with known risk factors. Read More

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http://dx.doi.org/10.4103/jrpp.JRPP_18_29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121764PMC
September 2018

Peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy.

Rom J Ophthalmol 2018 Apr-Jun;62(2):138-143

Frelance Physician, Diyarbakır, Turkey.

We aimed to investigate the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell complex (mGCC) thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy (crNAION) analyzed by spectral domain optical coherence tomography (SD-OCT). Patients with crNAION, and healthy control subjects were enrolled in the study. All participants underwent SD-OCT for measurement of pRNFL, mGCC, and central macular thickness (CMT). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117526PMC
September 2018
6 Reads

Optic Neuropathy and Macular Ischemia Associated with Neurosarcoidosis: A Case Report.

Turk J Ophthalmol 2018 Aug 4;48(4):202-205. Epub 2018 Sep 4.

University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey.

In this study, we present a case of bilateral optic neuropathy and macular ischemia in the right eye associated with neurosarcoidosis. A 26-year-old woman presented to our clinic with complaints of bilateral blurred vision. Bilateral granulomatous anterior uveitis, vitritis, optic neuropathy, and macular ischemia were detected in the right eye in slit-lamp examination. Read More

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http://dx.doi.org/10.4274/tjo.49799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126102PMC
August 2018
13 Reads

Color Doppler Flow Imaging of Retrobulbar Ocular Blood Flow Changes in Retinal Artery Occlusions Caused by Cosmetic Facial Filler Injections.

Ophthalmic Plast Reconstr Surg 2018 Sep 4. Epub 2018 Sep 4.

Department of Ophthalmology and Shanghai Key Laboratory of Visual Impairment and Restoration, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.

Purpose: This study aimed to evaluate the effects of retinal artery occlusions caused by cosmetic facial filler injections on the retrobulbar blood flow parameters.

Methods: This was a retrospective, noncomparative case series. Ten consecutive patients with fundus artery occlusions caused by facial filler injections were evaluated using color Doppler flow imaging (CDFI). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001208DOI Listing
September 2018
2 Reads

Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache.

J Clin Neurol 2018 Oct 6;14(4):577-579. Epub 2018 Sep 6.

Department of Neurology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3988/jcn.2018.14.4.577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172488PMC
October 2018
1 Read

Anterior Ischemic Optic Neuropathy After Dental Extraction.

J Neuroophthalmol 2018 Aug 31. Epub 2018 Aug 31.

Background: While often idiopathic, anterior ischemic optic neuropathy occasionally may occur from an identifiable cause.

Methods: Observational case report.

Results: A 19-year-old woman with unremarkable medical and ophthalmic histories developed visual loss from nonarteritic anterior ischemic optic neuropathy in her right eye after otherwise uneventful dental extraction of the inferior third molars. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9921
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http://dx.doi.org/10.1097/WNO.0000000000000711DOI Listing
August 2018
8 Reads

Recurrent orbital bone sub-periosteal hematoma in sickle cell disease: a case study.

BMC Ophthalmol 2018 Aug 28;18(1):211. Epub 2018 Aug 28.

Department Of Ophthalmology, Faculty of Medicine, Taif University, Taif, Saudi Arabia.

Background: Sickle cell disease is a common inherited hemoglobinopathy and is associated with high morbidity and mortality. Vaso-occlusive crises commonly occur in individuals with SCD that results in high morbidity due to end-organ ischemia and infarction. These include splenic infarction, pulmonary involvement, acute chest syndrome, and orbital compression syndrome. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0884-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114482PMC
August 2018
9 Reads

Spectral-Domain Optical Coherence Tomography of the Vitreopapillary Interface in Acute Nonarteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2018 Nov 8;195:199-208. Epub 2018 Aug 8.

Department of Ophthalmology, Duke Eye Center and Duke University Medical Center, Durham, North Carolina, USA. Electronic address:

Purpose: To use spectral-domain optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of nonarteritic anterior ischemic optic neuropathy (NAION).

Design: Retrospective cohort study.

Methods: Setting: Single academic center. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.08.002DOI Listing
November 2018
9 Reads

Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis.

Invest Radiol 2018 Nov;53(11):698-704

Radiologisches Zentrum Rosenheim, Rosenheim, Germany.

Objectives: Arteritic anterior ischemic optic neuropathy (A-AION) caused by inflammatory occlusion of the posterior ciliary arteries is the most common reason for irreversible vision loss in patients with giant cell arteritis. Atypical clinical presentation and negative funduscopy can delay systemic high-dose corticosteroid therapy to prevent impending permanent blindness and involvement of the contralateral eye.The purpose of this study was to assess the diagnostic accuracy of 3-dimensional (3D) high-resolution T1-weighted black-blood magnetic resonance imaging (T1-BB-MRI) for the detection of posterior ciliary artery involvement in patients with giant cell arteritis and funduscopic A-AION. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000500DOI Listing
November 2018
14 Reads
4.440 Impact Factor

Update on Perioperative Ischemic Optic Neuropathy Associated With Non-ophthalmic Surgery.

Front Neurol 2018 10;9:557. Epub 2018 Jul 10.

Departments of Ophthalmology and Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, United States.

Perioperative visual loss (POVL) is a rare, serious complication of non-ophthalmic surgeries. Ischemic optic neuropathy (ION), and retinal arterial occlusion (RAO) are the main causes (1, 2). Less frequent are cortical blindness (3), acute glaucoma (4), and choroidal and vitreous hemorrhage (5). Read More

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http://dx.doi.org/10.3389/fneur.2018.00557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048244PMC
July 2018
1 Read

Incidence and Mimickers of Acute Idiopathic Optic Neuritis: Analysis of 291 Consecutive Patients from Southern Finland.

Ophthalmic Epidemiol 2018 Oct - Dec;25(5-6):386-391. Epub 2018 Jul 24.

b Neurology , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

Purpose: To estimate the population-based incidence of acute idiopathic optic neuritis (ON) and analyse its differential diagnosis in patients referred with symptoms suggestive of ON.

Methods: Patients with suspected ON referred to the Helsinki University Hospital, serving a population of 1.5 million in Southern Finland, were reviewed between 1st May 2008 and 14th April 2012. Read More

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http://dx.doi.org/10.1080/09286586.2018.1500614DOI Listing

Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema.

Indian J Ophthalmol 2018 08;66(8):1144-1148

Neuro-Ophthamology Services, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: The purpose of this study is to detect the optic nerve head (ONH) and peripapillary perfusion in eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION) compared to the fellow normal eyes using optical coherence tomography angiography (OCTA) and to compare with nonischemic disc edema (papilledema).

Methods: Retrospective analysis of patients with unilateral NAION who underwent OCTA was performed. All patients underwent comprehensive ocular examination including visual field testing. Read More

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http://dx.doi.org/10.4103/ijo.IJO_179_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080459PMC
August 2018
1 Read

Oral Anti-Vascular Endothelial Growth Factor Drugs and Ocular Adverse Events.

J Ocul Pharmacol Ther 2018 Jul/Aug;34(6):432-435. Epub 2018 Jul 13.

2 Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine , One Hospital Drive, Columbia, Missouri.

Purpose: To evaluate possible associations between oral anti-vascular endothelial growth factor (VEGF) drugs and ocular side effects.

Methods: Spontaneous reports were collected and evaluated by the National Registry of Drug-Induced Ocular Side Effects on the three oral anti-VEGF drugs (pazopanib, sorafenib, and sunitinib) for possible ocular side effects.

Results: Reported side effects include blurred or decreased vision (389 cases); periocular or eyelid edema (273 cases); superficial anterior segment toxicity (270 cases); conjunctival, retinal, or vitreous bleeding (77 cases); retinal detachments (RDs) or retinal tears (RTs) (75 cases); extraocular muscle disorders, including ptosis (51 cases); discoloration of eyelashes (36 cases); retinal arterial or venous occlusions (26 cases); optic nerve disorders, including papilledema and ischemic optic neuropathy (21 cases); uveitis (10 cases); and macular edema (7 cases). Read More

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http://dx.doi.org/10.1089/jop.2018.0019DOI Listing
July 2018
2 Reads

Optical coherence tomography angiography at the acute phase of optic disc edema.

Eye Vis (Lond) 2018 23;5:15. Epub 2018 Jun 23.

1Service d'Ophtalmologie, CHU de Bordeaux, Bordeaux, France.

Background: The differential diagnosis of optic disc edema at the acute phase can be challenging. OCT angiography (OCTA) is a new technology allowing the visualization of the peripapillary vascular network and optic disc capillaries. The peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy (NAION) were reported. Read More

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http://dx.doi.org/10.1186/s40662-018-0109-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015448PMC

Steroid Treatment of Optic Neuropathies.

Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.

The etiologies of optic neuropathy include inflammation, ischemia, toxic and metabolic injury, genetic disease, and trauma. There is little controversy over the practice of using steroids in the treatment of optic neuritis--it is well established that intravenous steroid treatment can speed visual recovery but does not alter final visual function. However, there is controversy surrounding the acceptable routes of administration, dosage, and course of treatment. Read More

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http://dx.doi.org/10.22608/APO.2018127DOI Listing
August 2018
3 Reads

Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function.

PLoS One 2018 28;13(6):e0199793. Epub 2018 Jun 28.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, United States of America.

Purpose: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of non-glaucomatous optic neuropathy in older adults. Optical coherence tomographic angiography (OCT-A) is an emerging, non-invasive method to study the microvasculature of the posterior pole, including the optic nerve head. The goal of this study was to assess the vascular changes in the optic nerve head and peripapillary area associated with NAION using OCT-A. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199793PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023180PMC
June 2018
4 Reads

Non-arteritic anterior ischaemic optic neuropathy secondary to menorrhagia in a young healthy woman.

BMJ Case Rep 2018 Jun 27;2018. Epub 2018 Jun 27.

Ophthalmology Department, Universiti Sains Malaysia - Health Campus, Kubang Kerian, Malaysia.

Non-arteritic anterior ischaemic optic neuropathy (NAION) may develop due to severe anaemia and hypotension which is seen in acute blood loss. The devastating visual loss is often irreversible. We report a case of NAION in a 20-year-old healthy woman, who presented on the third day of a heavy menstrual cycle with hypovolaemic shock. Read More

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http://dx.doi.org/10.1136/bcr-2018-225113DOI Listing

Case report: giant cell arteritis in a patient with carotid atherosclerosis - a diagnostic dilemma.

Authors:
Beenish Fayyaz

J Community Hosp Intern Med Perspect 2018 12;8(3):134-137. Epub 2018 Jun 12.

Internal Medicine, Greater Baltimore Medical Center, Towson, MD, USA.

Carotid atherosclerosis and giant cell arteritis (GCA) are two distinct medical conditions with an overlapping clinical spectrum of vascular symptoms such as vision loss and ischemic stroke. This is because both diseases cause arterial ischemia with a predilection for carotid vasculature. In addition, high-vascular risk individuals who are diagnosed with GCA are usually elderly with age >55 years with high-vascular risk and thus can have underlying atherosclerosis. Read More

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http://dx.doi.org/10.1080/20009666.2018.1458571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998284PMC
June 2018
1 Read

Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma.

Eur J Ophthalmol 2018 Jun 1:1120672118782101. Epub 2018 Jun 1.

1 Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Purpose: To compare the optic nerve head morphology among primary open-angle glaucoma, non-arteritic anterior ischemic optic neuropathy eyes, their fellow healthy eyes and control eyes, using spectral-domain optical coherence tomography with enhanced depth imaging.

Methods: Observational cross-sectional study including 88 eyes of 68 patients. In this study, 23 non-arteritic anterior ischemic optic neuropathy eyes, 17 fellow unaffected eyes, 25 primary open-angle glaucoma eyes, and 23 age-matched control eyes were included. Read More

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http://dx.doi.org/10.1177/1120672118782101DOI Listing
June 2018
11 Reads

The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.

Sex Med 2018 Sep 5;6(3):185-192. Epub 2018 Jun 5.

Department of Urology, Minimally Invasive Surgery Center, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Urology, Guangzhou, China; Guangdong Key Laboratory of Urology, Guangzhou, China. Electronic address:

Introduction: Phosphodiesterase type 5 inhibitors (PDE5-Is) are first-line drugs for erectile dysfunction. Non-arteritic anterior ischemic optic neuropathy (NAION) has been linked with PDE5-I use. However, no meta-analysis or conclusive review has explored the association between NAION and PDE5-I use. Read More

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http://dx.doi.org/10.1016/j.esxm.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085407PMC
September 2018
16 Reads

The role of Optical Coherence Tomography in optic neuropathies.

Rom J Ophthalmol 2018 Jan-Mar;62(1):3-14

Department of Ophthalmology, "N. Oblu" Clinical Emergency Hospital, Iaşi, Romania.

Optical neuropathies are neuro-ophthalmologic disorders, the main symptoms of which are the decrease of visual acuity and the alteration of the color vision. Optical coherence tomography has been one of the most important innovations in ophthalmology, which offered the possibility to analyze specific structures of the retina. Optical coherence tomography performs in vivo, real-time, noncontact scanning and provides cross-sectional and volumetric images with a resolution approaching that of histology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959022PMC
July 2018
2 Reads

The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy.

Exp Eye Res 2018 Sep 21;174:147-151. Epub 2018 May 21.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address:

Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in the elderly. The role of the genetic polymorphisms of Atonal Homolog 7 (ATOH7), Endothelin-1 (ET-1) and Angiotensin Converting Enzyme (ACE) in NAION and the combined effects of the gene-gene and gene-medical comorbidities on NAION were not clear. We conducted a perspective, case-control study. Read More

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http://dx.doi.org/10.1016/j.exer.2018.05.021DOI Listing
September 2018
4 Reads

Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy.

Ophthalmology 2018 Jun;125(6):903

Neuro-ophthalmology Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ophtha.2018.01.029DOI Listing

Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy.

Int Ophthalmol 2018 May 10. Epub 2018 May 10.

Department of Ophthalmology, School of Medicine, Afyon Kocatepe University, Ali Çetinkaya Kampusü, İzmir Karayolu 7. Km, 03200, Afyonkarahisar, Turkey.

Purpose: The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare with healthy control eyes (CE) using spectral domain-optical coherence tomography (SD-OCT).

Methods: This study included 28 patients and age, sex and refraction-matched 28 control subjects. Mean GCC thickness and peripapillary RNFL thickness in four quadrants measured by cirrus SD-OCT were evaluated in both AE and FE of patients and CE. Read More

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http://dx.doi.org/10.1007/s10792-018-0942-yDOI Listing
May 2018
2 Reads

Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report.

BMC Neurol 2018 May 8;18(1):64. Epub 2018 May 8.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: POEMS syndrome is a plasma cell disorder, which clinically manifests from paraneoplastic syndrome: polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. The most common ocular manifestation is optic disc swelling, whereas other ocular manifestations; cystoid macular edema, serous macular detachment, venous sinus thrombosis, infiltrative orbitopathy, uveitis, neovascularization of the disc, peripapillary choroidal neovascularization and optic disc drusen, had also been reported.

Case Presentation: A 52-year-old Thai man presented with 5-day sudden painless visual loss in the left eye. Read More

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http://dx.doi.org/10.1186/s12883-018-1071-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938810PMC
May 2018
6 Reads

Optical Coherence Tomography Angiography in Optic Disc Swelling.

Am J Ophthalmol 2018 Jul 5;191:116-123. Epub 2018 May 5.

Department of Ophthalmology, University of Colorado, School of Medicine, Aurora, Colorado, USA.

Purpose: To compare optical coherence tomography angiography (OCT-A) of peripapillary total vasculature and capillaries in patients with optic disc swelling.

Design: Cross-sectional study.

Methods: Twenty nine eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 44 eyes with papilledema, 8 eyes with acute optic neuritis, and 48 eyes of normal subjects were imaged using OCT-A. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.04.017DOI Listing

A sticky situation.

Surv Ophthalmol 2018 Sep - Oct;63(5):736-744. Epub 2018 Apr 27.

Duke Eye Center and Duke University Medical Center, Department of Ophthalmology, Durham, North Carolina, USA; Duke University Medical Center, Departments of Neurology and Neurosurgery, Durham, North Carolina, USA.

An 81-year-old man with bilateral progressively blurry vision and optic disc swelling was referred for evaluation. Examination and ancillary testing confirmed a diagnosis of bilateral vitreopapillary traction accompanied by unilateral tractional retinoschisis in the right eye. Pars plana vitrectomy was performed to release the traction in both the eyes. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.04.004DOI Listing
September 2018

Steroids versus No Steroids in Nonarteritic Anterior Ischemic Optic Neuropathy: A Randomized Controlled Trial.

Ophthalmology 2018 Oct 25;125(10):1623-1627. Epub 2018 Apr 25.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To examine the role of oral steroid therapy in the treatment of nondiabetic cases of acute nonarteritic anterior ischemic optic neuropathy (NAAION).

Design: Randomized double-blind clinical trial.

Participants: Thirty-eight patients with acute nondiabetic NAAION divided into 2 arms of 19 patients each. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420173271
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http://dx.doi.org/10.1016/j.ophtha.2018.03.032DOI Listing
October 2018
15 Reads

Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report.

Medicine (Baltimore) 2018 Apr;97(17):e0321

Laboratory of Retinal Cell Biology.

Introduction: Recent progress in medical technology has resulted in improved surgical outcomes of pars plana vitrectomy (PPV); with microincision systems, the incidence of procedure-related complications during surgery has been reduced. However, unpredictable visual field defects after PPV remain an unresolved issue. A few reports have shown that damage to the retinal neurofibers owing to dry-up during air/fluid exchange or retinal neurotoxicity of the dye used to visualize the internal limiting membrane (ILM), as well as unintentional removal of retinal neurofibers during ILM peeling, are responsible for such visual field disorders. Read More

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http://dx.doi.org/10.1097/MD.0000000000010321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944518PMC

Prognosis and monitoring of giant cell arteritis and associated complications.

Expert Rev Clin Immunol 2018 05 26;14(5):379-388. Epub 2018 Apr 26.

b Division of Rheumatology , Mayo Clinic College of Medicine , Rochester , MN , USA.

Introduction: Giant cell arteritis (GCA) is the most common systemic vasculitis in people over the age of 50 years. Prospective imaging studies in GCA highlight the systemic nature of this vasculitis. Areas covered: This review summarizes literature using PubMed on complications of GCA and its treatment. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1467758DOI Listing
May 2018
4 Reads

Caspases in retinal ganglion cell death and axon regeneration.

Cell Death Discov 2017 3;3:17032. Epub 2017 Jul 3.

Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.

Retinal ganglion cells (RGC) are terminally differentiated CNS neurons that possess limited endogenous regenerative capacity after injury and thus RGC death causes permanent visual loss. RGC die by caspase-dependent mechanisms, including apoptosis, during development, after ocular injury and in progressive degenerative diseases of the eye and optic nerve, such as glaucoma, anterior ischemic optic neuropathy, diabetic retinopathy and multiple sclerosis. Inhibition of caspases through genetic or pharmacological approaches can arrest the apoptotic cascade and protect a proportion of RGC. Read More

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http://dx.doi.org/10.1038/cddiscovery.2017.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903394PMC
July 2017
2 Reads