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Vaccines (Basel) 2022 Jun 10;10(6). Epub 2022 Jun 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.

People are advised to receive a vaccine booster as the Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge, but various adverse ocular reactions after vaccination have been reported. NAION following COVID-19 vaccination appears extremely rarely. Here, we report a case of a 61-year-old female with sudden painless blurred vision developing NAION after receiving ChAdOx1 nCoV-19 (AstraZeneca) vaccination and provide an in-depth explanation of the possible mechanisms regarding the hypercoagulable state after vaccination. Read More

J Ophthalmic Inflamm Infect 2022 Jun 23;12(1):20. Epub 2022 Jun 23.

Ophthalmology Department, Medical University Pleven, 91 Vladimir Vazov str, Pleven, Bulgaria.

Background: The aim of this report is to describe ocular side effects in patients who received one of the two COVID-19 vaccines - Astra Zeneca or Pfizer-Biontech and to contribute to the common understanding of the COVID-19 vaccination process.

Results: Three patients reactivated underlying herpetic disease and developed uveitis and keratitis. Two of them were vaccinated with Pfizer and one was with Astra Zeneca. Read More

Rheumatol Int 2022 Jun 21. Epub 2022 Jun 21.

Department of Rheumatology, Patras University Hospital, University of Patras Medical School, Patras, Greece.

Prompt initiation of pulse glucocorticoid treatment is recommended in case of visual symptoms and suspected or proven giant cell arteritis (GCA). Pulse treatment in most cases prevents involvement of an initially unaffected fellow eye. We present the case of a biopsy-proven GCA in a 79-year-old man, complicated by sequential bilateral blindness. Read More

Exp Eye Res 2022 Jun 9:109139. Epub 2022 Jun 9.

Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, 94303, USA; Department of Neurology, Stanford University School of Medicine, Stanford, CA, 94304, USA. Electronic address:

Nonarteritic anterior ischemic optic neuropathy (NAION) is a common acute optic neuropathy and cause of irreversible vision loss in those older than 50 years of age. There is currently no effective treatment for NAION and yet the biological mechanisms leading to neuronal loss are not fully understood. Glial cells activation and intercommunication mediated by molecules such as gap junction protein Connexin 43 (Cx43) is thought to modulate neuronal fate in central nervous system disorders. Read More

IDCases 2022 18;28:e01521. Epub 2022 May 18.

Department of Internal Medicine, Groene Hart Ziekenhuis, Gouda, The Netherlands.

The incidence of syphilis is on the rise worldwide and can pose many diagnostic and therapeutic difficulties for doctors. Given the wide variety of presenting symptoms, syphilis is also known as the great imitator, which in turn frequently leads to a pronounced diagnostic- and therapeutic delay for patients. Here we present a case report of syphilitic uveitis and papillitis accompanied by acute vision loss, a rare presentation of a tertiary syphilis infection that clinically mimicked a giant cell arteritis (GCA) or arteritic anterior ischemic optic neuropathy (AAION). Read More

Rinsho Shinkeigaku 2022 May 28. Epub 2022 May 28.

Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute.

A 60-year-old man with a history of bronchial asthma and nasal polyp presented with loss of vision in the right eye. His visual loss progressed within a single day, and he presented to our hospital 5 days after the onset of the symptom. Fundoscopy showed swelling and hemorrhage of the right optic disc. Read More

Int J Gen Med 2022 24;15:5173-5179. Epub 2022 May 24.

Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

Purpose: To evaluate visual-related quality of life (VR-QoL) and its association with optic nerve head microvasculature in individuals with nonarteritic anterior ischemic optic neuropathy (NAION) evaluated at the acute stage.

Methods: In this retrospective case-control study, 23 NAION eyes at the acute stage and 25 age and gender matched healthy eyes were included, respectively. All included eyes underwent a complete ophthalmic examination including optical coherence tomography (OCT) and OCT angiography (OCTA). Read More

Nervenarzt 2022 Jun 25;93(6):629-642. Epub 2022 May 25.

Universitäts-Augenklinik, Department für Augenheilkunde, Universitätsklinikum Tübingen, Elfriede-Aulhorn-Straße 7, 72076, Tübingen, Deutschland.

There are many disease patterns that are treated jointly by neurologists and ophthalmologists, for which optical coherence tomography (OCT) is of important differential diagnostic significance. In this context neurologists are mainly confronted by two patient collectives: patients with an acute ischemic event, who present with an acute but painless monocular visual deterioration (for central retinal artery occlusion) or with a monocular visual field defect (for arterial branch occlusion or anterior ischemic optic neuropathy). The second collective is patients without ophthalmological symptoms but with conspicuous optic nerve findings (papilledema or optic disc drusen). Read More

Case Rep Nephrol Dial 2022 Jan-Apr;12(1):57-62. Epub 2022 Mar 29.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Vision loss from nonarteritic anterior ischemic optic neuropathy (NAION) is a rare complication of hemodialysis. Here, we present a case in a young woman and discuss the pathophysiology and implications for the nephrologist. A 24-year-old woman with end-stage renal disease developed unilateral, painless vision loss following treatment with hemodialysis. Read More

Bioeng Transl Med 2022 May 7;7(2):e10289. Epub 2022 Jan 7.

Institute of Eye Research Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Hualien Taiwan.

An ischemic insult at optic nerve (ON) is followed by detrimental neuroinflammation that results in progressive and long-lasting retinal ganglion cell (RGC) death and vision loss. Icariin was reported to be a safe and effective natural anti-inflammatory drug. Herein, we evaluated the long-term therapeutic effects of a single intravitreal injection of poly(lactide-co-glycolide) PLGA-icariin in a rat model of anterior ischemic optic neuropathy (rAION). Read More

Eur J Ophthalmol 2022 May 15:11206721221100901. Epub 2022 May 15.

Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

Purpose: To describe two cases of severe acute bilateral optic disc edema that occurred in patients with diabetes mellitus shortly after the initiation of intensified antihyperglycemic therapy.

Methods: Retrospective observational case report.

Case Description: Two patients with type 1 diabetes presented for routine retinopathy screening with asymptomatic optic disc edema. Read More

BMJ Case Rep 2022 May 13;15(5). Epub 2022 May 13.

Neuro-Ophthalmology, Narayana Nethralaya, Bangalore, Karnataka, India.

A woman in her 50s presented with diminution of vision in her left eye (OS) 4 days after COVISHIELD vaccination. She had been diagnosed with non-arteritic anterior ischaemic optic neuropathy (NA-AION) of right eye (OD) 8 months earlier. The present episode revealed a best-corrected visual acuity (BCVA) of 20/50 in OD and 20/20 in OS with grade 1 relative afferent pupillary defect. Read More

Invest Ophthalmol Vis Sci 2022 04;63(4):23

Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Purpose: Nonarteritic anterior ischemic optic neuropathy (NAION) has been associated with a thickened choroid at the optic nerve head (ONH). Here, we use computational modeling to better understand how choroidal expansion and choroidal geometry influence tissue deformation within the ONH relative to intraocular pressure (IOP) and intracranial pressure (ICP) effects.

Methods: Using a model of the posterior eye that included the sclera, peripapillary sclera, annular ring, pia mater, dura mater, neural tissues, Bruch's membrane, choroid, and lamina cribrosa, we examined how varying material properties of ocular tissues influenced ONH deformations under physiological and supra-physiological, or "pathological," conditions. Read More

Retin Cases Brief Rep 2022 Apr 18. Epub 2022 Apr 18.

Eye Research Center, The Five Senses Health Institute, Rassoul Akram hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Vascular insufficiency of the optic nerve head is the cause of non-arteritic ischemic optic neuropathy (NAION). Carotid artery abnormalities are now considered as a predisposing factor for developing NAION. In this report, we present a case of NAION associated with ipsilateral internal carotid artery hypoplasia. Read More

J Neuroophthalmol 2022 06 25;42(2):154-162. Epub 2022 Mar 25.

Department of Neurology (IL, ML), Division of Neuroimmunology and Neuroinfectious Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and Treadwell Virtual Library for the Massachusetts General Hospital (ML), Boston, Massachusetts.

Background: A worldwide mass vaccination campaign against the coronavirus disease 2019 (COVID-19) pandemic is currently underway. Although the safety data of the clinical trials did not report specific concerns regarding neuro-ophthalmological adverse events, they involved a limited number of individuals and were conducted over a relatively short time. The aim of the current review is to summarize the available postmarketing data regarding the occurrence of neuro-ophthalmological and other ocular complications of the COVID-19 vaccines. Read More

J Neuroophthalmol 2022 Mar 24. Epub 2022 Mar 24.

Department of Ophthalmology (GH), University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey; and Department of Ophthalmology (OB), Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey.

Background: This cross-sectional study aimed to evaluate the peripapillary vessel density (VD), peripapillary retinal nerve fiber layer (RNFL) thickness values of eyes with atrophic nonarteritic anterior ischemic optic neuropathy (NAION), and unaffected fellow eyes.

Methods: Peripapillary VDs and RNFL thicknesses in the peripapillary region and 4 sectors (superior, inferior, nasal, and temporal) were evaluated using optical coherence tomography angiography among 19 atrophic NAION eyes, 19 unaffected fellow eyes, and 22 age-matched and sex-matched healthy controls.

Results: The NAION eyes had lower peripapillary VD and RNFL thickness values in all areas compared with both the fellow and the healthy control eyes (P < 0. Read More

J Neuroophthalmol 2022 Mar 23. Epub 2022 Mar 23.

Michael G. DeGroote School of Medicine (JSX), McMaster University, Hamilton, Ontario, Canada; Department of Ophthalmology and Vision Sciences (JAM), University of Toronto, Toronto, Ontario, Canada; Division of Neurology (JAM), Department of Medicine, University of Toronto, Toronto, Ontario, Canada; and Kensington Vision and Research Centre (JAM), Toronto, Ontario, Canada.

Ocul Immunol Inflamm 2022 Apr 12:1-4. Epub 2022 Apr 12.

Department of Ophthalmology, Bernice and Harvey Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Purpose: To report a case of non-arteritic anterior ischemic optic neuropathy (NAAION) with macular star after receiving the second dose of SARS-CoV-2 vaccination.

Method: Case report.

Observation: A 51-year-old male presented with acute visual disturbances one day after the second dose of BNT162b2 mRNA SARS-CoV-2 vaccination. Read More

Can J Neurol Sci 2022 Apr 11:1-7. Epub 2022 Apr 11.

Am J Ophthalmol Case Rep 2022 Jun 25;26:101433. Epub 2022 Mar 25.

Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.

Purpose: To report a case of branch retinal artery occlusion (BRAO) followed by branch retinal vein occlusion (BRVO) and paracentral acute middle maculopathy (PAMM) in a patient with confirmed calciphylaxis.

Observations: A 52-year-old female with a history of BRAO in the right eye one-year prior presented with decreased vision and a new inferotemporal scotoma. Computed tomography angiography of the head and neck demonstrated vascular calcifications at the origin of both ophthalmic arteries, which were otherwise poorly visualized. Read More

Cureus 2022 Feb 25;14(2):e22612. Epub 2022 Feb 25.

Department of Internal Medicine, Lilavati Hospital and Research Center, Mumbai, IND.

A 61-year-old male presented with visual loss in the left eye. A CT scan of the chest revealed multiple lung cavities in both lungs. He had a positive C-ANCA suggestive of granulomatosis with polyangiitis. Read More

Eur J Ophthalmol 2022 Mar 29:11206721221090033. Epub 2022 Mar 29.

485662Oftalvist, Valencia, Spain.

Introduction: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of optic nerve swelling and optic neuropathy in adults over 50 years of age. It has been rarely reported during pregnancy, mostly related to systemic and ocular predisposing conditions.

Case Report: We report the case of a 44 years-old healthy female with no previous remarkable clinical history. Read More

Comput Math Methods Med 2022 18;2022:2935992. Epub 2022 Mar 18.

Department of Ophthalmology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Background: To evaluate the clinical effects and safety of glucocorticoids for patients with nonarteritic anterior ischemic optic neuropathy (NAION).

Methods: The databases MEDLINE, Embase, PubMed, Cochrane Database, and Web of Science were used to search for the relevant studies, and full-text articles that reported on the evaluation of glucocorticoids vs. no-treatment or placebo for patients with NAION. Read More

J Anaesthesiol Clin Pharmacol 2021 Oct-Dec;37(4):580-585. Epub 2022 Jan 6.

Department of Anaesthesiology and Critical Care, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.

Background And Aims: AA present prospective study was conducted to evaluate ocular changes occurring in patients undergoing spine surgery in the prone position.

Material And Methods: A total of 44 patients of either sex, belonging to American society of Anaesthesiology I and II (aged 18-60 years) scheduled for elective spine surgery in prone position were enrolled in the study. Baseline IOP and MAP measurement were taken prior to induction. Read More

Am J Case Rep 2022 Mar 27;23:e935095. Epub 2022 Mar 27.

Department of Ophthalmology, Hospital University of Cruces, Barakaldo, Spain.

BACKGROUND Since the start of vaccination efforts against COVID-19, several presumed secondary ocular events have been described. We present 2 cases of non-arteritic anterior ischemic optic neuropathy (NA-AION) in patients whose symptoms appeared in the first 2 weeks after administration of the Pfizer-BioNTech COVID-19 mRNA BNT162b2/Cominarty vaccine. CASE REPORT The first patient was a 53-year-old man who presented visual field disturbance in the right eye 7 days after the first vaccine dose, and who consulted a physician 10 days after the second dose, when he experienced loss of vision in the left eye. Read More

Clin Ophthalmol 2022 18;16:851-860. Epub 2022 Mar 18.

Department of Ophthalmology, Wroclaw Medical University, Wrocław, Poland.

Buerger's disease, also known as thromboangiitis obliterans, is a disorder of primarily small and medium arteries and veins of the arms and legs. We have failed to find a comprehensive review discussing a possible link between the disease and the eyes. The aim of this study is to review current knowledge on the topic of ocular manifestations in the course of Buerger's disease. Read More

Int J Environ Res Public Health 2022 02 26;19(5). Epub 2022 Feb 26.

Department of Ophthalmology, Medical School, University of Pécs, 7632 Pécs, Hungary.

Background: Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) is the second most common cause of optic nerve-related permanent visual loss in adults.

Aim: We aimed to analyze the efficacy of the noninvasive and minimally invasive therapeutic options of NAION.

Methods: We performed a systematic literature search in MEDLINE, EMBASE, and CENTRAL from inception to 10 June 2019 to identify the studies that report on the effect of different therapies on visual acuity (VA) and visual field (VF). Read More

Biomed Res Int 2022 27;2022:4808194. Epub 2022 Feb 27.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: To demonstrate the changes in the retinal nerve fiber layer (RNFL) after orbital decompression for thyroid eye disease (TED).

Methods: We retrospectively enrolled 52 surgical TED patients, 30 nonsurgical TED patients, and 30 control subjects. Five surgical TED eyes with disc edema were excluded. Read More

Clin Exp Ophthalmol 2022 04 16;50(3):334-344. Epub 2022 Mar 16.

Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), University of Western Australia, Perth, Western Australia, Australia.

There is a growing body of literature on the effects of sleep disorders, in particular obstructive sleep apnoea (OSA), on ocular health, with consistent evidence of an increased risk of floppy eyelid syndrome, non-arteritic anterior ischaemic optic neuropathy, diabetic macular oedema, and other retinal vasculature changes in individuals with OSA. However, reports on OSA's associations with glaucoma, papilloedema, diabetic retinopathy, central serous chorioretinopathy, and keratoconus have been conflicting, while links between OSA and age-related macular degeneration have only been described fairly recently. Despite numerous suggestions that OSA treatment may reduce risk of these eye diseases, well-designed studies to support these claims are lacking. Read More