2,534 results match your criteria Optic Neuritis Imaging


A new association: acute macular neuroretinopathy in acute optic neuritis.

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Clinical Research Department, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Background: Acute optic neuritis (AON) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (AMN) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases. Read More

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http://dx.doi.org/10.1111/aos.14054DOI Listing
February 2019

Bedside Transorbital Ultrasound in the Clinical Evaluation of Pediatric Optic Neuritis in the Emergency Department.

J Emerg Med 2019 Feb 8. Epub 2019 Feb 8.

Children's Emergency, KK Women's and Children's Hospital, Singapore.

Background: Headache and monocular visual disturbance are worrisome pediatric presenting complaints in the emergency department. Appropriate and timely initial evaluation is critical. Most would opt for urgent computer tomography in such cases. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.12.042DOI Listing
February 2019

Multiple Sclerosis and Autoimmune Neurology of the Central Nervous System.

Med Clin North Am 2019 Mar 3;103(2):325-336. Epub 2018 Dec 3.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Autoimmune disorders of the central nervous system are common and often affect people in the most productive years of their lives. Among primary autoimmune diseases of the central nervous system, multiple sclerosis is most prevalent in the United States. Many other autoantibody-mediated neurologic syndromes have been identified within the past 2 to 3 decades, including neuromyelitis optica and anti-N-methyl-D aspartate receptor encephalitis. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.004DOI Listing
March 2019
1 Read

Eyes are Mirror of the Brain: Comparison of Multiple Sclerosis Patients and Healthy Controls Using OCT.

Int J Neurosci 2019 Jan 29:1-9. Epub 2019 Jan 29.

a Abant Izzet Baysal University , College of Medicine, Department of Ophthalmology , Bolu , Turkey.

Objective: To evaluate the thickness of choroid and retinal nerve fiber layer (RNFL) in Multiple Sclerosis (MS) patients with and without optic neuritis using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: In this cross-sectional study, both eyes of 52 MS patients [n = 104 eyes; 62 eyes of MS patients without optic neuritis (MS-NON) and 42 eyes of MS patients with optic neuritis (MS-ON)] and only one eye of 36 healthy control subjects (n = 36 eyes) were evaluated. Complete ophthalmologic examination and EDI-OCT scanning were completed for all participants. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576660DOI Listing
January 2019

[Clinical analysis of neuromyelitis optica spectrum disorders in childhood].

Zhonghua Er Ke Za Zhi 2019 Feb;57(2):118-124

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To explore clinical features and the effect of treatment of neuromyelitis optica spectrum disorders (NMOSD) in childhood. Children who were hospitalized in Department of Pediatrics, Peking University First Hospital from January 2013 to June 2018 and meeting diagnostic criteria of NMOSD proposed by the International Panel for NMOSD Diagnosis in 2015 were summarized and followed up. The basic information, symptoms of each attack, locations and patterns of new lesions, features of cerebrospinal fluid, serologic markers, treatments and outcomes in these patients were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.02.011DOI Listing
February 2019

What Does Optical Coherence Tomography Offer for Evaluating Physical Disability in Patients with Multiple Sclerosis?

Noro Psikiyatr Ars 2018 ;55(Suppl 1):S37-S40

Dokuz Eylul University Faculty of Medicine, Eye Diseases, İzmir, Turkey.

Visual dysfunction is one of the most common clinical manifestations of multiple sclerosis (MS). For example, optic neuritis is the onset symptom in 20% of patients with MS. Visual pathway impairment presents in most patients with MS, including patients who have not experienced optic neuritis. Read More

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http://dx.doi.org/10.29399/npa.23327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278624PMC
January 2018

Varicella zoster virus reactivation antedating ipsilateral brainstem stroke.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena.

itor Title: Varicella zoster virus reactivation antedating ipsilateral brainstem stroke Authors: Giuliana Galassi1, Maurilio Genovese2, Marisa Meacci3, Marcella Malagoli2 Affiliations: 1Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Italy, 2Neuroradiology Service, University Hospital of Modena, Italy, 3Department of Laboratory Medicine and Patholgy, Microbiology and Virology Unit, University Hospital of Modena, Italy Corresponding Author: Giuliana Galassi, MD, Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Via P. Giardini 1455, Modena, Italy, Tel: 39-3497325802, Email: giulianagalassi46@gmail.com Abstract: Varicella zoster virus (VZV) infection and reactivation are associated with a number of neurologic conditions. Read More

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August 2018
1 Read

Simultaneous bilateral optic neuritis in China: clinical, serological and prognostic characteristics.

Acta Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China.

Purpose: To analyse the clinical characteristics of simultaneous bilateral ON patients in China.

Methods: This retrospective study was done on 51 primary bilateral ON patients between April 2008 and July 2016 at the Chinese People's Liberation Army General Hospital. Fifty eight primary unilateral ON patients formed the control group. Read More

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http://dx.doi.org/10.1111/aos.14013DOI Listing
January 2019
2 Reads

Image Artifacts in Optical Coherence Tomography Angiography Among Patients With Multiple Sclerosis.

Curr Eye Res 2019 Jan 9:1-6. Epub 2019 Jan 9.

a Wilmer Eye Institute , Johns Hopkins University School of Medicine , Baltimore , MD , USA.

Purpose: To evaluate artifacts in optical coherence tomography angiography (OCT-A) images of multiple sclerosis (MS) patients and healthy controls.

Materials And Methods: This was a prospective cross-sectional study conducted at the Department of Neurology and the Wilmer Eye Institute at Johns Hopkins Hospital. Subjects included patients with an established diagnosis of MS and healthy volunteers. Read More

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http://dx.doi.org/10.1080/02713683.2019.1565892DOI Listing
January 2019
1.663 Impact Factor

Altered Brain Structure and Functional Connectivity of Primary Visual Cortex in Optic Neuritis.

Front Hum Neurosci 2018 20;12:473. Epub 2018 Dec 20.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Previous studies have revealed brain adaptations to injury that occurs in optic neuritis (ON); however, the mechanisms underlying the functional connectivity (FC) and gray matter volume (GMV) changes in ON have not been clarified. Here, 51 single attack ON patients and 45 recurrent attacks ON patients were examined using structural MRI and resting-state functional MRI (RS-fMRI), and compared to 49 age- and gender-matched healthy controls (HC). FC analysis with a seed in primary visual cortex (V1 area) was used to assess the differences among three groups. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306625PMC
December 2018

A rare concurrence: Antibodies against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate receptor in a child.

Mult Scler Relat Disord 2018 Dec 14;28:101-103. Epub 2018 Dec 14.

Mersin University, Faculty of Medicine, Department of Pediatric Neurology, Mersin, Turkey. Electronic address:

Background: Myelin Oligodendrocyte Glycoprotein antibodies (MOG) may be used as a biomarker for diagnosis of many demyelinating diseases. Especially, patients of acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), aquaporin-4 (AQP4) seronegative neuromyelitis optica spectrum disorder (NMOSD), monophasic or recurrent optic neuritis (ON), transverse myelitis and N-methyl-d-aspartate (NMDA) receptor encephalitis (NMDARe) can overlap with Myelin Oligodendrocyte Glycoprotein antibodies. We present a child with autoimmune encephalitis in whom antibodies against Myelin Oligodendrocyte Glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) were simultaneously detected. Read More

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http://dx.doi.org/10.1016/j.msard.2018.12.017DOI Listing
December 2018

Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis.

Expert Rev Neurother 2018 Dec 27:1-13. Epub 2018 Dec 27.

a NeuroCure Clinical Research Center , Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany.

Introduction: Multiple Sclerosis (MS) is the most common chronic autoimmune neuroinflammatory condition in young adults. It is often accompanied by optic neuritis (ON) and retinal neuro-axonal damage causing visual disturbances. Optical coherence tomography (OCT) is a sensitive non-invasive method for quantifying intraretinal layer volumes. Read More

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http://dx.doi.org/10.1080/14737175.2019.1559051DOI Listing
December 2018

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody.

JAMA Neurol 2018 Dec 21. Epub 2018 Dec 21.

Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.

Importance: Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment.

Objective: To evaluate the clinical, radiologic, and prognostic features of MOG-IgG myelitis and compare with myelitis with aquaporin-4-IgG (AQP4-IgG) and multiple sclerosis (MS).

Design, Setting, And Participants: We retrospectively identified 199 MOG-IgG-positive Mayo Clinic patients from January 1, 2000, through December 31, 2017, through our neuroimmunology laboratory. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4053DOI Listing
December 2018
1 Read

Neurological update: MOG antibody disease.

J Neurol 2018 Dec 19. Epub 2018 Dec 19.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.

Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOG-AD) is now recognised as a nosological entity with specific clinical and paraclinical features to aid early diagnosis. Although no age group is exempt, median age of onset is within the fourth decade of life, with optic neuritis being the most frequent presenting phenotype. Disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. Read More

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http://dx.doi.org/10.1007/s00415-018-9122-2DOI Listing
December 2018
1 Read

Diagnostic Errors in Initial Misdiagnosis of Optic Nerve Sheath Meningiomas.

JAMA Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

Importance: Diagnostic errors can lead to the initial misdiagnosis of optic nerve sheath meningiomas (ONSM), which can lead to vision loss.

Objective: To identify factors contributing to the initial misdiagnosis of ONSM.

Design, Setting, And Participants: We retrospectively reviewed 35 of 39 patients with unilateral ONSM (89. Read More

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2018.3989DOI Listing
December 2018
20 Reads

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma.

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000722DOI Listing
October 2018
11 Reads

Optic nerve double inversion recovery hypersignal in patients with clinically isolated syndrome is associated with asymptomatic gadolinium-enhanced lesion.

Mult Scler 2018 Dec 3:1352458518815797. Epub 2018 Dec 3.

Department of Neurology, Roger Salengro Hospital, CHU Lille, University of Lille, Lille, France/Department of Neuroradiology, Roger Salengro Hospital, CHU Lille, University of Lille, Lille, France/UMR 1171, CHU Lille, University of Lille, Lille, France.

Background:: Optic nerve involvement is not considered in dissemination in space (DIS) or time (DIT) of multiple sclerosis (MS) lesions.

Objectives:: To evaluate frequency of optic nerve involvement using three-dimensional (3D)-double inversion recovery (DIR) sequence in clinically isolated syndrome (CIS) and to measure its relationship with DIS and DIT (2010 and 2017 McDonald criteria).

Methods:: From November 2013 to August 2016, 57 CIS patients underwent 3T-magnetic resonance imaging (3T-MRI) including 3D-DIR sequence and optical coherence tomography (OCT) at 3 months after CIS. Read More

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http://dx.doi.org/10.1177/1352458518815797DOI Listing
December 2018
3 Reads

Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report.

J Med Case Rep 2018 Dec 3;12(1):357. Epub 2018 Dec 3.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 301B Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong SAR.

Background: Limbic encephalitis is characterized by rapid onset of working memory deficit, mood changes, and often seizures. The condition has a strong paraneoplastic association, but not all cases are invariably due to tumors.

Case Presentation: We present a case of limbic encephalitis in a Chinese patient who initially presented to our hospital with optic neuritis and no other neurological symptoms. Read More

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http://dx.doi.org/10.1186/s13256-018-1893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276199PMC
December 2018
1 Read

A multi-facet comparative analysis of neuromyelitis optica spectrum disorders in patients with seropositive and seronegative AQP4-IgG.

Medicine (Baltimore) 2018 Nov;97(48):e13100

Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Introduction: Neuromyelitis optica spectrum disorders (NMOSD), a rare, serious, demyelinating disease of the central nervous system (CNS), is associated with immunoglobulin G (IgG) antibodies targeting aquaporin-4 (AQP4-IgG). This study retrospectively analyzed the clinical features of 67 patients. 49 and 18 of 67 cases (male/female: 11/56) were AQP4-IgG (+) and AQP4-IgG (-), respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000013100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283140PMC
November 2018
1 Read
5.723 Impact Factor

[Elderly onset case of neuromyelitis optica that developed at the age of 90].

Rinsho Shinkeigaku 2018 Dec 29;58(12):761-763. Epub 2018 Nov 29.

Department of Neurology, Hiroshima City Asa Citizens Hospital.

We report a case of neuromyelitis optica (NMO) that was diagnosed at the age of 90. After initially developing visual loss in the right eye, a patient was diagnosed with optic neuritis. Although treatment with methylprednisolone therapy provided relief, 3 months later she developed optic neuritis on the other side. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001208DOI Listing
December 2018
1 Read

Optic Nerve Cysticercosis at the Orbital Apex Presenting as Optic Neuritis.

Authors:
Neha Goel

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):508-510

ICARE Eye Hospital and Postgraduate Institute, Noida, Uttar Pradesh, India.

Purpose: To describe an unusual presentation of ocular cysticercosis and highlight the role of imaging in diagnosis.

Case Report: A 33-year-old female presented with loss of vision in her right eye and features suggesting optic neuritis. Magnetic resonance imaging (MRI) of the brain and orbits revealed a cystic lesion with peripheral rim enhancement in the optic nerve substance at the orbital apex. Read More

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http://dx.doi.org/10.4103/jovr.jovr_251_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210869PMC
November 2018

[Optical Coherence Tomography in Disorders of the Central Nervous System].

Klin Monbl Augenheilkd 2018 Nov 20;235(11):1242-1258. Epub 2018 Nov 20.

NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Retinal changes and visual symptoms are present in several inflammatory, degenerative and tumorous disorders of the central nervous system (CNS). Optical coherence tomography (OCT) is a method that can be used in clinical practice to detect and quantify the structural correlates of these visual symptoms in neurological disorders. OCT is a non-invasive imaging technique, based on interferometry, which can create high-resolution images of the retina and measure the thickness and volume of the different retinal layers. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0715-7961
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http://dx.doi.org/10.1055/a-0715-7961DOI Listing
November 2018
15 Reads

Macular Hole After Poppers (Alkyl Nitrate) Inhalation in a Child.

Ophthalmic Surg Lasers Imaging Retina 2018 Nov;49(11):897-900

The authors present the first case of macular hole (MH) after a single inhalation of poppers. A 13-year-old girl presented with vision loss in the left eye (OS). Pediatric and neurology exams were normal. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2018
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http://dx.doi.org/10.3928/23258160-20181101-12DOI Listing
November 2018
21 Reads

Color vision testing versus pattern visual evoked potentials and optical coherence tomography parameters in subclinical optic nerve involvement in multiple sclerosis.

J Clin Neurosci 2018 Nov 16. Epub 2018 Nov 16.

Antalya Training and Research Hospital, Neurology Department, Muratpasa, 07050 Antalya, Turkey.

Acute idiopathic demyelinating optic neuritis is frequently the initial manifestation of multiple sclerosis (MS). We aimed to discuss the value of color vision testing to detect possible optic nerve involvement in patients with MS who had no history of optic neuritis. We evaluated color vision with Farnsworth-Munsell 100 (FM-100) hue test. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.011DOI Listing
November 2018
5 Reads
1.318 Impact Factor

Frequency and immunophenotype of IL10-producing regulatory B cells in optic neuritis.

Immunology 2019 Mar 27;156(3):259-269. Epub 2018 Dec 27.

MS Clinic, Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Glostrup, Denmark.

Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased frequency and functionality of Breg cells correlate with disease activity and the percentage of IL-10-producing Breg cells decreases during relapse and normalizes in remission. Optic neuritis (ON) is a common first clinical manifestation of MS and IL-10-producing Breg cells may be crucial in the transition from ON to MS, we therefore investigate the frequency and function of Breg cells in ON as a clinical model of early demyelinating disease. Read More

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http://doi.wiley.com/10.1111/imm.13024
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http://dx.doi.org/10.1111/imm.13024DOI Listing
March 2019
14 Reads

Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion.

Radiol Case Rep 2019 Feb 13;14(2):226-229. Epub 2018 Nov 13.

Division of Neuroradiology, Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Room S-047, Stanford, CA 94305-5105, USA.

Malignant optic glioma presents a clinical and diagnostic challenge, as early imaging findings overlap with other more common causes of optic nerve enhancement and enlargement, potentially leading to delay in diagnosis. This rare diagnosis carries an extremely poor prognosis, with death usually occurring within 1 year. We present a case of malignant optic glioma that was initially diagnosed as optic neuritis and central retinal vein occlusion, and we emphasize the importance of serial imaging and definitive biopsy to promote early diagnosis and treatment of this entity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183031
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http://dx.doi.org/10.1016/j.radcr.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234704PMC
February 2019
8 Reads

HIV infection associated neuromyelitis optica spectrum disorder: Clinical features, imaging findings, management and outcomes.

Mult Scler Relat Disord 2019 Jan 13;27:289-293. Epub 2018 Nov 13.

Department of Neurology, St. John's Medical College Hospital, Sarjapura Road, Bengaluru, Karnataka 560034, India.

Introduction: HIV Infection associated NMOSD (HIV-NMOSD) is a recently recognized entity. Management of patients with HIV-NMOSD is a challenge. Here we report our own experience of HIV-NMOSD along with a complete review of all the cases of HIV-NMOSD reported in literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183049
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http://dx.doi.org/10.1016/j.msard.2018.11.014DOI Listing
January 2019
11 Reads

MRI findings in pediatric neuromyelitis optica spectrum disorder with MOG antibody: Four cases and review of the literature.

Brain Dev 2018 Nov 14. Epub 2018 Nov 14.

Department of Pediatrics, Yokohama City University Medical Center, Japan.

Background: Myelin oligodendrocyte glycoprotein antibodies (MOG Abs) are frequently detected in pediatric acquired demyelinating syndrome (ADS), and MOG-Ab-positive ADS differs from multiple sclerosis (MS) and aquaporin-4 (AQP4)-Ab-positive neuromyelitis optica spectrum disorder (NMOSD) in terms of age distribution, therapeutic response, and prognosis.

Methods: Based on medical records, we retrospectively evaluated patients with MOG-Ab-positive NMOSD treated in the acute phase who were followed up in the chronic phase at our hospital from January 2011 to December 2017.

Results: The patients comprised two boys and two girls aged 3-12 (median, 8) years. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.10.011DOI Listing
November 2018

Detecting optic nerve lesions in clinically isolated syndrome and multiple sclerosis: double-inversion recovery magnetic resonance imaging in comparison with visually evoked potentials.

J Neurol 2019 Jan 16;266(1):148-156. Epub 2018 Nov 16.

Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Background And Aim: Optic neuritis (ON) is a frequent manifestation of multiple sclerosis (MS), traditionally diagnosed clinically and by visually evoked potentials (VEP). However, ON can also be assessed by MRI. Here we compare the diagnostic performance of 3D-double inversion recovery-MRI (3D-DIR) and VEPs in patients with definite MS or clinically isolated syndrome (CIS). Read More

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http://link.springer.com/10.1007/s00415-018-9114-2
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http://dx.doi.org/10.1007/s00415-018-9114-2DOI Listing
January 2019
11 Reads

Factors Related to Long Term Motor, Behavioral, and Scholastic Outcome in Children with Acute Disseminated Encephalomyelitis.

Pediatr Neurol 2018 Dec 21;89:49-57. Epub 2018 Sep 21.

Government Medical College Trivandrum, Kerala, India.

Objective: We studied the long-term outcome of Acute disseminated encephalomyelitis (ADEM).

Methods: We performed a retrospective cohort study among children diagnosed with ADEM (fulfilling IPMSSG criteria). Major outcome variables were motor deficit, scholastic underperformance, and behavioral abnormality. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.08.015DOI Listing
December 2018
1 Read

Color Doppler imaging evaluation of blood flow parameters in ophthalmic and posterior ciliary arteries and optic nerve diameter in chronic optic neuritis in multiple sclerosis patients.

Mult Scler Relat Disord 2019 Jan 3;27:195-199. Epub 2018 Oct 3.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background And Purpose: Optic neuritis (ON) is a common clinical manifestation of Multiple Sclerosis (MS), which is associated with reduced visual acuity, blurred vision, blindness and retro-bulbar pain. In several studies, specific relations between optic nerve diameter and hemodynamics of the eye bulb arteries with ON have been reported. However, no consensus has been reached in this regard. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183036
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http://dx.doi.org/10.1016/j.msard.2018.10.001DOI Listing
January 2019
8 Reads

Diagnosis and Treatment of NMO Spectrum Disorder and MOG-Encephalomyelitis.

Front Neurol 2018 23;9:888. Epub 2018 Oct 23.

NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead to recurrent attacks of optic neuritis, myelitis and/or brainstem syndromes. In some patients with symptoms of NMOSD, no AQP4-Abs but Abs against myelin-oligodendrocyte-glycoprotein (MOG) are detectable. Read More

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http://dx.doi.org/10.3389/fneur.2018.00888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206299PMC
October 2018
26 Reads

Chronic relapsing inflammatory optic neuropathy (CRION): a manifestation of myelin oligodendrocyte glycoprotein antibodies.

J Neuroinflammation 2018 Oct 31;15(1):302. Epub 2018 Oct 31.

Department of Neurology, College of Medicine, Seoul National University, 101 Daehak-Ro, Jongno-Gu, Seoul, 110-744, Republic of Korea.

Background: Key clinical features of chronic relapsing inflammatory optic neuropathy (CRION) include relapsing inflammatory optic neuritis (ON) and steroid dependency, both of which have been reported among patients with myelin oligodendrocyte glycoprotein antibodies (MOG-Abs). We investigated the relevance of the presence of serum MOG-IgG with the current diagnostic criteria for CRION among patients with idiopathic inflammatory optic neuritis (iON).

Methods: Retrospective reviews of a database prospectively collated between 2011 and 2017 from the tertiary referral center for multiple sclerosis and neuromyelitis optica were performed. Read More

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http://dx.doi.org/10.1186/s12974-018-1335-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208174PMC
October 2018
1 Read

Anti-aquaporin-4 Antibody Positive Optic Neuritis Following Scrub Typhus in an Elderly Female.

Neurologist 2018 Nov;23(6):183-184

Department of Neurology, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, Korea.

Introduction: Aquaporin-4 antibody (AQP4-Ab) is specific for neuromyelitis optica spectrum disorder (NMOSD) and so is helpful to distinguish NMOSD from other autoimmune diseases. Several viral infections may play a role in the onset of NMOSD.

Case Report: We describe a case of a previous healthy 82-year-old woman who presented with acute visual loss occurring 3 weeks after scrub typhus. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000196DOI Listing
November 2018
6 Reads

Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis.

Int J Ophthalmol 2018 18;11(10):1649-1656. Epub 2018 Oct 18.

Department of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Aim: To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ON.

Methods: This prospective study was conducted at the Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Thailand, between January, 2015 and December, 2016. We enlisted patients over 18 years of age with history of ON and categorized patients into 4 groups: 1) aquaporin 4 antibodies (AQP4-IgG) positive; 2) multiple sclerosis (MS); 3) myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) positive; 4) idiopathic-ON patients. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192964PMC
October 2018
3 Reads

Tuberculous Pachymeningitis Presenting as a Diffused Dural Thickening in a Patient with Chronic Headache and Recurrent Neurological Abnormalities for More than a Decade: A Case Report and a Review of the Literature.

Case Rep Infect Dis 2018 1;2018:3012034. Epub 2018 Oct 1.

Consultant Physician, Department of Internal Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Background: Tuberculous pachymeningitis is a rare form of extrapulmonary tuberculosis usually suspected from the detection of thickening of the dura in contrast-enhanced magnetic resonance imaging. Progressive nature of the disease can lead to chronic headache with focal neurological signs due to compression from the thickened dura.

Case Report: We report a 40-year-old female who presented with chronic headache over a decade associated with recurrent neurological abnormalities including optic neuritis, hemisensory loss, migraine, facial nerve palsy, and recurrent vertigo. Read More

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https://www.hindawi.com/journals/criid/2018/3012034/
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http://dx.doi.org/10.1155/2018/3012034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188763PMC
October 2018
12 Reads

More than meets the eye: Varicella zoster virus-related orbital apex syndrome.

Indian J Ophthalmol 2018 Nov;66(11):1647-1649

Department of Internal Medicine, Singapore General Hospital; Department of Ophthalmology, Duke-NUS Medical School, Singapore.

A 67-year-old male patient with poorly controlled type-2 diabetes mellitus developed an orbital apex syndrome and anterior cavernous syndrome secondary to herpetic zoster ophthalmicus (HZO), despite being on oral acyclovir. Urgent treatment with intravenous acyclovir led to improvement of the orbital and ocular inflammation but had no effect on the complete ophthalmoplegia and profound visual loss. At the 9-month follow-up visit, the patient had complete unilateral ophthalmoplegia and monocular blindness due to optic atrophy. Read More

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http://dx.doi.org/10.4103/ijo.IJO_592_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213683PMC
November 2018
7 Reads

Bilateral optic neuropathy with central diabetes insipidus in a child.

Indian J Ophthalmol 2018 Nov;66(11):1642-1644

Institute of Neuroscience, SIMS Hospitals, Chennai, Tamil Nadu, India.

Central nervous system germ cell tumors are rare and they occur in the first two decades of life. Optic nerve germinomas can sometimes mimic optic nerve inflammation. In this case report, we discuss an 11-year-old girl who presented with features of presumed bilateral optic neuritis and developed polyuria and polydipsia, subsequently she was diagnosed to have infiltrative etiology. Read More

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http://dx.doi.org/10.4103/ijo.IJO_281_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213697PMC
November 2018
5 Reads

Neuromyelitis optica spectrum disorders with and without connective tissue disorders.

BMC Neurol 2018 Oct 24;18(1):177. Epub 2018 Oct 24.

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin, 300052, China.

Background: Neuromyelitis optica spectrum disorders (NMOSD) often coexist with connective tissue disorders (CTD). The aim of this study was to investigate and compare the features of NMOSD with and without CTD.

Methods: NMOSD patients with (n = 18) and without CTD (n = 39) were enrolled, and the clinical, laboratory, and magnetic resonance imaging (MRI) features of the two groups were assessed. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
Publisher Site
http://dx.doi.org/10.1186/s12883-018-1182-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199722PMC
October 2018
15 Reads
2.040 Impact Factor

Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis.

Neurol Clin Neurosci 2018 Sep 10;6(5):146-147. Epub 2018 Jul 10.

Department of Neurology JA Toride Medical Center Toride Ibaraki Japan.

Because fungi usually spread from the paranasal sinuses to the orbital apex in invasive fungal sinusitis (IFS), IFS often presents as an orbital apex syndrome (OAS) characterized by dysfunction of cranial nerves II, III, IV, V1, and VI. We report a case of sphenoid sinus mucormycosis that presented as isolated retrobulbar optic neuropathy. A 94-year-old woman presented with acute blindness in the right eye. Read More

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http://dx.doi.org/10.1111/ncn3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175081PMC
September 2018
2 Reads

Syringomyelia-like syndrome in neuromyelitis optica spectrum disorder complicated with Sjogren's syndrome: a case report.

BMC Neurol 2018 Oct 9;18(1):168. Epub 2018 Oct 9.

Department of Neurology, The Affiliated Hospital of Wei fang Medical University, No 2428 Yuhe Road, Weifang, 261031, Shandong, China.

Background: Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary Sjogren's syndrome (pSS) is extremely rare. Here, we would like to report a case of a patient with syringomyelia-like syndrome in NMOSD complicated with Sjogren's Syndrome. Read More

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http://dx.doi.org/10.1186/s12883-018-1170-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178268PMC
October 2018
6 Reads

Concurrence of juvenile idiopathic arthritis and primary demyelinating disease in a young child.

Mult Scler Relat Disord 2019 Jan 3;27:20-22. Epub 2018 Oct 3.

Department of Pediatric Neurology, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

Case Report: The association of juvenile idiopathic arthritis (JIA) and primary demyelinating disease of central nervous system (CNS) in the same patient is rare. Here we present a 10-year-old girl formerly diagnosed with JIA who presented with acute total vision loss. Magnetic resonance imaging of the brain and spinal cord showed bilateral optic neuritis and T2 hyperintense lesions in the brain, cerebellum and cervical spinal cord, some of them gadolinium-enhancing. Read More

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http://dx.doi.org/10.1016/j.msard.2018.10.002DOI Listing
January 2019
8 Reads

Uncommon manifestation of leptospirosis: a diagnostic challenge.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Leptospirosis is a zoonotic disease commonly affecting the tropical countries. It may have protean clinical manifestations including hepatorenal dysfunction, myocarditis, pulmonary haemorrhage, meningitis, optic neuritis and rhabdomyolysis. Neurological manifestation of leptospirosis without the classical hepatorenal dysfunction is a rare entity. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22528
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http://dx.doi.org/10.1136/bcr-2018-225281DOI Listing
October 2018
2 Reads

Isolated optic neuritis with a concurrent abnormal trigeminal nucleus on imaging: case report of a rare complication of herpes zoster ophthalmicus.

BMC Neurol 2018 Oct 4;18(1):165. Epub 2018 Oct 4.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocular complication following HZO, has been reported in 1.9% of HZO-affected eyes. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
Publisher Site
http://dx.doi.org/10.1186/s12883-018-1168-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171195PMC
October 2018
6 Reads

Colon cancer and IgG4-related disease with orbital inflammation and bilateral optic perineuritis: A case report.

Medicine (Baltimore) 2018 Sep;97(39):e12197

Ophthalmology Department, Oculoplastics.

Rationale: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition of unknown cause. Cancer might be related to the development of certain IgG4-RD but to date, little literature documents it.

Patient Concerns: A 78-year old man presented with unilateral proptosis responsive to steroids, initially attributed to nonspecific orbital inflammation. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0001
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000012197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181517PMC
September 2018
5 Reads

[A case of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-N-methyl-D-aspartate (NMDA) receptor antibody-positive encephalitis with optic neuritis].

Rinsho Shinkeigaku 2018 Oct 29;58(10):636-641. Epub 2018 Sep 29.

Department of Neurology, National Hospital Organization Beppu Medical Center.

A 20-year-old female was hospitalized due to generalized seizure two weeks after an infection. She reported disorientation, neck stiffness and weakness in her legs. MRI FLAIR images and TWI on her first visit to our hospital showed hyperintense lesions in the bilateral cingulate gyrus and the medial region of the superior frontal gyrus. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001194DOI Listing
October 2018
2 Reads

Inflammatory demyelinating diseases of the central nervous system in Niger.

Rev Neurol (Paris) 2018 Sep 27. Epub 2018 Sep 27.

Service de médecine interne et spécialités médicales, Hôpital National de Niamey, BP 238, Niamey, Niger; Faculté des sciences de la santé, Université Abdou Moumouni de Niamey, Niamey, Niger.

Background: In sub-Saharan Africa (SSA), few studies have been reported on inflammatory demyelinating diseases of the central nervous system (CNS). Neuromyelitis optica spectrum disorders (NMOSD) seems to be the most frequent inflammatory demyelinating disease of CNS in sub-Saharan Africans or people of sub-Saharan African descent.

Methods: We report the observations of seven patients from Niger diagnosed with inflammatory demyelinating diseases of CNS over a period of 21 years (1996-2017). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00353787183057
Publisher Site
http://dx.doi.org/10.1016/j.neurol.2018.05.003DOI Listing
September 2018
3 Reads

Cases of visual impairment caused by cerebral venous sinus occlusion-induced intracranial hypertension in the absence of headache.

BMC Neurol 2018 Sep 29;18(1):159. Epub 2018 Sep 29.

Department of Ophthalmology, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.

Background: Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing these conditions, through proper ophthalmological examination and brain imaging, is very important to avoid delayed diagnosis and treatment. Read More

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http://dx.doi.org/10.1186/s12883-018-1156-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162896PMC
September 2018
4 Reads

Proceedings of the Neuro-Ophthalmology Program of the 33rd Asia-Pacific Academy of Ophthalmology Congress, Hong Kong, 8-11 February 2018.

Neuroophthalmology 2018 Oct 23;42(5):326-333. Epub 2018 May 23.

Department of Ophthalmology, Hong Kong Eye Hospital, Kowloon, Hong Kong.

The 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress was held on Feb 8-11, 2018 in Hong Kong. This report summarized the highlights of the neuro-ophthalmology program of the Congress, including the scientific symposia (invited and submitted) and the social activities. Read More

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http://dx.doi.org/10.1080/01658107.2018.1463386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152500PMC
October 2018
3 Reads

Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis.

J Magn Reson Imaging 2018 Sep 25. Epub 2018 Sep 25.

Department of Radiology, Chinese PLA General Hospital, Beijing, P.R. China.

Background: Neuromyelitis optica-optic neuritis (NMO-ON) patients are routinely treated with intravenous methylprednisolone (IVMP). For the patients nonresponsive to IVMP, more effective but aggressive therapy of plasma exchange (PE) should be employed instead of IVMP in the first line.

Purpose: To assess the visual outcomes of NMO-ON patients after IVMP by radiomics analysis of whole brain diffusion tensor imaging (DTI) data. Read More

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http://doi.wiley.com/10.1002/jmri.26326
Publisher Site
http://dx.doi.org/10.1002/jmri.26326DOI Listing
September 2018
10 Reads