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Front Neurol 2018 30;9:1031. Epub 2018 Nov 30.

Neurology Unit, Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Centre, Neuroscience Section, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Common Variable Immunodeficiency (CVID) is a group of heterogeneous primary immunodeficiencies sharing defective B lymphocytes maturation and dysregulated immune response and resulting in impaired immunoglobulin production. Clinical picture encompasses increased susceptibility to infections, hematologic malignancies, inflammatory, and autoimmune diseases. Neurological manifestations are uncommon and optic neuritis has been previously reported only in one case with bilateral involvement. Read More

J Neurol Sci 2018 Nov 28;396:225-231. Epub 2018 Nov 28.

Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China. Electronic address:

Background And Objective: Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON.

Methods: Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Read More

J Neuroinflammation 2018 Oct 31;15(1):302. Epub 2018 Oct 31.

Department of Neurology, College of Medicine, Seoul National University, 101 Daehak-Ro, Jongno-Gu, Seoul, 110-744, Republic of Korea.

Background: Key clinical features of chronic relapsing inflammatory optic neuropathy (CRION) include relapsing inflammatory optic neuritis (ON) and steroid dependency, both of which have been reported among patients with myelin oligodendrocyte glycoprotein antibodies (MOG-Abs). We investigated the relevance of the presence of serum MOG-IgG with the current diagnostic criteria for CRION among patients with idiopathic inflammatory optic neuritis (iON).

Methods: Retrospective reviews of a database prospectively collated between 2011 and 2017 from the tertiary referral center for multiple sclerosis and neuromyelitis optica were performed. Read More

Neurologist 2018 Nov;23(6):183-184

Department of Neurology, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, Korea.

Introduction: Aquaporin-4 antibody (AQP4-Ab) is specific for neuromyelitis optica spectrum disorder (NMOSD) and so is helpful to distinguish NMOSD from other autoimmune diseases. Several viral infections may play a role in the onset of NMOSD.

Case Report: We describe a case of a previous healthy 82-year-old woman who presented with acute visual loss occurring 3 weeks after scrub typhus. Read More

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

Indian J Ophthalmol 2018 Nov;66(11):1647-1649

Department of Internal Medicine, Singapore General Hospital; Department of Ophthalmology, Duke-NUS Medical School, Singapore.

A 67-year-old male patient with poorly controlled type-2 diabetes mellitus developed an orbital apex syndrome and anterior cavernous syndrome secondary to herpetic zoster ophthalmicus (HZO), despite being on oral acyclovir. Urgent treatment with intravenous acyclovir led to improvement of the orbital and ocular inflammation but had no effect on the complete ophthalmoplegia and profound visual loss. At the 9-month follow-up visit, the patient had complete unilateral ophthalmoplegia and monocular blindness due to optic atrophy. Read More

BMC Neurol 2018 Oct 24;18(1):177. Epub 2018 Oct 24.

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin, 300052, China.

Background: Neuromyelitis optica spectrum disorders (NMOSD) often coexist with connective tissue disorders (CTD). The aim of this study was to investigate and compare the features of NMOSD with and without CTD.

Methods: NMOSD patients with (n = 18) and without CTD (n = 39) were enrolled, and the clinical, laboratory, and magnetic resonance imaging (MRI) features of the two groups were assessed. Read More

J Neuroinflammation 2018 Oct 22;15(1):294. Epub 2018 Oct 22.

Departments of Medicine and Physiology, University of California, 1246 Health Sciences East Tower, 513 Parnassus Ave, San Francisco, CA, 94143-0521, USA.

Background: Aquaporin-4-immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorder (herein called NMO) is an autoimmune disease of the central nervous system in which AQP4-IgG binding to AQP4 on astrocytes results in complement-dependent astrocyte injury and secondary inflammation, demyelination, and neuron loss. We previously reported evidence for a complement bystander mechanism for early oligodendrocyte injury in NMO. Herein, we tested the hypothesis that complement bystander injury, which involves diffusion to nearby cells of activated soluble complement components from complement-injured astrocytes, is a general phenomenon that may contribute to neuronal injury in NMO. Read More

BMC Neurol 2018 Oct 9;18(1):168. Epub 2018 Oct 9.

Department of Neurology, The Affiliated Hospital of Wei fang Medical University, No 2428 Yuhe Road, Weifang, 261031, Shandong, China.

Background: Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary Sjogren's syndrome (pSS) is extremely rare. Here, we would like to report a case of a patient with syringomyelia-like syndrome in NMOSD complicated with Sjogren's Syndrome. Read More

Mult Scler Relat Disord 2018 Oct 3;27:20-22. Epub 2018 Oct 3.

Department of Pediatric Neurology, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

Case Report: The association of juvenile idiopathic arthritis (JIA) and primary demyelinating disease of central nervous system (CNS) in the same patient is rare. Here we present a 10-year-old girl formerly diagnosed with JIA who presented with acute total vision loss. Magnetic resonance imaging of the brain and spinal cord showed bilateral optic neuritis and T2 hyperintense lesions in the brain, cerebellum and cervical spinal cord, some of them gadolinium-enhancing. Read More

BMC Neurol 2018 Oct 4;18(1):165. Epub 2018 Oct 4.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocular complication following HZO, has been reported in 1.9% of HZO-affected eyes. Read More

Medicine (Baltimore) 2018 Sep;97(39):e12197

Ophthalmology Department, Oculoplastics.

Rationale: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition of unknown cause. Cancer might be related to the development of certain IgG4-RD but to date, little literature documents it.

Patient Concerns: A 78-year old man presented with unilateral proptosis responsive to steroids, initially attributed to nonspecific orbital inflammation. Read More

Rinsho Shinkeigaku 2018 Oct 29;58(10):636-641. Epub 2018 Sep 29.

Department of Neurology, National Hospital Organization Beppu Medical Center.

A 20-year-old female was hospitalized due to generalized seizure two weeks after an infection. She reported disorientation, neck stiffness and weakness in her legs. MRI FLAIR images and TWI on her first visit to our hospital showed hyperintense lesions in the bilateral cingulate gyrus and the medial region of the superior frontal gyrus. Read More

BMC Neurol 2018 Sep 29;18(1):160. Epub 2018 Sep 29.

Department of Clinical Sciences Lund, Ophthalmology, Lund University, Skane University Hospital, Ögonklinik A Kioskgatan 1, SE-221 85, Lund, Sweden.

Background: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.

Methods: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Read More

BMC Neurol 2018 Sep 29;18(1):159. Epub 2018 Sep 29.

Department of Ophthalmology, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.

Background: Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing these conditions, through proper ophthalmological examination and brain imaging, is very important to avoid delayed diagnosis and treatment. Read More

BMC Ophthalmol 2018 Sep 14;18(1):247. Epub 2018 Sep 14.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No. 54 Xianlie South Road, Guangzhou, 510060, People's Republic of China.

Background: Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe retinal nerve fiber layer (RNFL) damage. The optical coherence tomography (OCT) characteristics between NMOSD- ON and idiopathic optic neuritis (IDON) were seldom studied in Asians. Read More

BMJ Case Rep 2018 Sep 8;2018. Epub 2018 Sep 8.

Medicine of the Elderly Department, Royal Infirmary of Edinburgh, Edinburgh, UK.

This case describes an 81-year-old woman with a history of Sjögren's syndrome presenting with recurrent falls and poor balance. She subsequently developed new and rapidly evolving neurology including hyperaesthesia, spastic paraplegia and sphincteric dysfunction. Following serial clinical reviews and detailed investigations, MRI (brainstem and cervicothoracic spine) and a seropositive result for aquaporin 4 IgG, a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) was made. Read More

Mult Scler Relat Disord 2018 Oct 31;25:329-333. Epub 2018 Aug 31.

Department of Neurology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Electronic address:

Background: Vitamin D deficiency is commonly found in multiple sclerosis (MS) and Neuromyelitis Optic (NMO) patients and can impair the immunological status. As a tropical country, Indonesia has a lot of sunshine throughout the year as a source of vitamin D. The aim of this study was to evaluate and compare the serum vitamin D-25(OH) level in Indonesian MS and NMO patients to healthy individuals. Read More

Mult Scler Relat Disord 2018 Oct 24;25:309-315. Epub 2018 Aug 24.

National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), Japan.

Background: Depression and anxiety are common in multiple sclerosis (MS) and recently, studies on these symptoms in neuromyelitis optica spectrum disorder (NMOSD) are increasing. Previous studies suggest that these symptoms have negative effects on the quality of life. Resilience has garnered more interest as one of the protective factors that works to prevent psychiatric symptoms in past decades. Read More

Mult Scler Relat Disord 2018 Oct 1;25:300-308. Epub 2018 Aug 1.

Department of Medicine, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Ministry of Health of Malaysia.

We performed a retrospective observational analytical study looking at the frequencies and characteristics of multiple sclerosis(MS) and neuromyelitis optica spectrum disorders(NMOSD) in consecutive patients with idiopathic inflammatory demyelinating disease (IIDDs) attending three centers (2009-2017). Of 523 patients with IIDDs, there were 173 patients with NMOSD and 230 patients with MS. The percentage of NMOSD: IIDDs was 33%. Read More

Mult Scler Relat Disord 2018 Oct 17;25:268-270. Epub 2018 Aug 17.

Division of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Demyelinating Diseases Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, Mexico City, Mexico. Electronic address:

Background: Previous studies have investigated the influence of neuromyelitis optica (NMO) on pregnancy in other ethnic groups. However, there are potential variations among ethnic groups. The obstetric outcome of Mexican patients with NMO and AQP4-IgG positivity (AQP4-IgG[+]) is currently unknown. Read More

Mult Scler Relat Disord 2018 Oct 13;25:258-264. Epub 2018 Aug 13.

Medicine (Neurology), University of British Columbia and The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. Electronic address:

Objective: We aimed to validate administrative case definitions to identify individuals with optic neuritis (ON) or transverse myelitis (TM), and to distinguish which of these individuals had a monophasic presentation versus multiple sclerosis (MS).

Methods: Using population-based administrative (health claims) data from Manitoba, Canada, we developed case definitions for ON and TM, and distinguished individuals who had monophasic presentations (ON-nonMS, TM-nonMS) versus those later diagnosed with MS (ON-MS, TM-MS). We compared performance of these case definitions to diagnoses based on medical records review in a reference cohort (n = 1251) using sensitivity, specificity, positive predictive value and negative predictive value. Read More

Mult Scler Relat Disord 2018 Oct 9;25:246-250. Epub 2018 Aug 9.

Center for Research on Neuroimmunological Diseases (CIEN), Institute for Neurological Research Dr. Raúl Carrea (FLENI), Montañeses 2325, Buenos Aires, Argentina; Center for Biostatistics, Epidemiology and Public Health (CEBES), Institute for Neurological Research Dr. Raúl Carrea (FLENI), Buenos Aires, Argentina. Electronic address:

Objective: Test the ability of a brain and spinal cord MRI criteria to differentiate neuromyelitis optica spectrum disorders and MOG-disease from MS. MRI criteria was further tested in patients with CIS and pediatric MS.

Background: MOG-disease and neuromyelitis optica spectrum disorders can present clinical and radiological features strikingly similar to those of MS. Read More

Curr Opin Ophthalmol 2018 Sep;29(5):419-422

Department of Pediatric Ophthalmology and Adult Strabismus, Wills Eye Hospital, Philadephia, PA.

Purpose Of Review: Pediatric optic neuritis may be challenging to diagnose and treat. Significant clinical investigation of optic neuritis occurring in adults guides current clinical practices. Differences in presentation and prognosis exist for pediatric patients with optic neuritis when compared with adults including the risk of developing multiple sclerosis. Read More

Indian J Gastroenterol 2018 Jul 8;37(4):365-369. Epub 2018 Aug 8.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Raebareli Road, Lucknow, 226 014, India.

Patients suffering from acute intractable vomiting are usually treated in the Gastroenterology department. The causes of acute intractable vomiting range from acute pancreatitis and acute intestinal obstruction to cardiac causes like acute myocardial infarction and neurological causes like posterior circulation stroke. However, most of the underlying causes of acute intractable vomiting also produce other telltale signs/symptoms. Read More

Mult Scler Relat Disord 2018 10 27;25:163-164. Epub 2018 Jul 27.

Icahn School of Medicine at Mount Sinai Beth Israel.

J Neurol 2018 Oct 2;265(10):2284-2294. Epub 2018 Aug 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

Objective: To evaluate volumetric changes and discriminative power of intra-retinal layers in early-stage multiple sclerosis (MS) using a 3D optical coherence tomography (OCT) imaging method based on an in-house segmentation algorithm.

Methods: 3D analysis of intra-retinal layers was performed in 71 patients with early-stage MS (mean disease duration 2.2 ± 3. Read More

Mult Scler Relat Disord 2018 Oct 21;25:104-107. Epub 2018 Jul 21.

Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. Electronic address:

Neuromyelitis optica (NMO), also known as Devic's disease, is a classical autoimmune disorder of the central nervous system (CNS). The relapsing-remitting disease course contributes to application of a variety of immunosuppressants to prevent further relapses after high-dose methylprednisolone pulse therapy for acute attacks. Azathioprine is one of the most widely used immunosuppressive drugs during the remission stage of NMO due to its good efficacy and favorable side-effect profile. Read More

Mult Scler Relat Disord 2018 Oct 17;25:87-94. Epub 2018 Jul 17.

Serviço de Neurologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: Antibodies against Myelin Oligodendrocyte glycoprotein (MOG-Ab) have been investigated as potential biological marker for neuromyelitis optica (NMO) and high-risk syndromes (HR) negative for AQP4-Ab in populations with different ethnic background. We tested AQP4 and MOG antibodies in a Brazilian population with high African ethnic background.

Method: The study population was composed of adult patients from Rio de Janeiro with inflammatory demyelinating diseases (new and old cases). Read More

Mult Scler Relat Disord 2018 Oct 20;25:83-86. Epub 2018 Jul 20.

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Background: Neuromyelitis optica spectrum disorders (NMOSD) typically lead to spastic paraparesis and spare the peripheral nervous system (PNS).

Case Report: Here, we describe an anti-aquaporin-4-seropositive NMOSD patient suffering from acute transverse myelitis with painful, flaccid paralysis and incontinence of urine and feces. Due to the involvement of the PNS as indicated by electrodiagnostic examination, we verified the expression of aquaporin-4-channels on the proximal dorsal spinal radix of rats by staining rat tissue with human NMOSD serum. Read More

Mult Scler Relat Disord 2018 Oct 24;25:73-76. Epub 2018 Jul 24.

Laboratory of Human Genetics of Neurological Disorders, Division of neuroscience, INSPE, San Raffaele Scientific Institute, Milan, Italy; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy; Department of Neurology and Multiple Sclerosis (MS) Research Centre, IRCCS Policlinico San Donato, Via Rodolfo Morandi, 26, 20097, San Donato Milanese, Milan, Italy. Electronic address:

The coexistence of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) in the same family is a rare event. We report a familial case originating from Sardinia of two siblings: one with NMOSD and one with MS. Human leukocyte antigen (HLA) typing showed that the two affected siblings were HLA-identical, sharing risk-increasing alleles, while a younger unaffected sister was haploidentical to her siblings but she also carried protective alleles. Read More

Mult Scler Relat Disord 2018 Oct 6;25:61-65. Epub 2018 Jul 6.

Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Beijing Integrative medicine on Encephalopathy Research Institution, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To assess the influences of pregnancy on disease progression of neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS).

Methods: A total of 148 NMOSD patients and 170 MS patients were reviewed retrospectively. The changes in mean annualized relapse rate (ARR) in NMOSD and MS during and after pregnancy were compared. Read More

Neuroradiology 2018 Sep 19;60(9):903-912. Epub 2018 Jul 19.

Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.

Purpose: Single-shot echo-planar imaging is the conventional diffusion-weighted imaging (C-DWI) sequence for evaluating orbital disease. However, its utility is restricted in small organs like the chiasma and optic nerve. This study was conducted to investigate the utility of field-of-view optimized and constrained undistorted single-shot diffusion-weighted imaging (FOCUS-DWI) for evaluating the chiasma and optic nerve in acute optic neuritis, making comparisons with C-DWI. Read More

Mult Scler Relat Disord 2018 Aug 4;24:151-156. Epub 2018 Jul 4.

Social and Administrative Pharmacy Excellence Research (SAPER) Unit, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudthaya Road, Phayathai, Ratchathewi, Bangkok 10400 Thailand. Electronic address:

Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum (NMOSD) cause several symptoms that negatively impact on patient's quality of life. No study has ever conducted to examine the quality of life of MS and NMOSD patients, especially in terms of health utility, among the non-western population. This study aims to examine health utility among MS and NMOSD patients in Thailand. Read More

Mult Scler Relat Disord 2018 Oct 10;25:21-25. Epub 2018 Jul 10.

Neuroimmunological Disorders Gene-Environment Epidemiology Laboratory, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, United States. Electronic address:

Background: Cardiovascular conditions are associated with poorer outcomes in multiple sclerosis (MS). Whether the burden of cardiovascular conditions differs between those with demyelinating disease and unaffected controls is not clear. The objective of this study is to investigate the burden and age of onset of cardiovascular conditions in a US population with MS, neuromyelitis optica spectrum disorder (NMOSD), or transverse myelitis (TM) to unaffected controls adjusting for likely confounders. Read More

J Clin Neurosci 2018 Sep 11;55:82-85. Epub 2018 Jul 11.

Department of Neurology, Huashan Hospital, Fudan University, Shanghai 20040, China; Institute of Neurology, Fudan University, Shanghai 20040, China. Electronic address:

In this study, we attempted to investigate the application of RNFL thickness detection in the early differential diagnosis among various types of idiopathic optic neuritis (ION). In comparison with 19 healthy controls (HC), retrospective analysis of quadrant RNFL thickness in 83 patients with ION was performed, including eighteen multiple sclerosis (MS), forty-five neuromyelitis optica spectrum disorder (NMOSD), twenty patients with other idiopathic optic neuritis (O-ION). Our results showed that mean and every quadrant RNFL thickness of MS, NMOSD and O-ION were thinner than those of HC (P < 0. Read More

Eye (Lond) 2018 Nov 4;32(11):1688-1696. Epub 2018 Jul 4.

Copenhagen University Department of Dermato-Venerology, Bispebjerg Hospital, Copenhagen, Denmark.

Background: To evaluate ophthalmic involvement in a long-term series of patients with en coup de sabre (ECS) close to the eye based on the hypothesis that this is not commonly affected, or simply under-reported.

Methods: An observational study of ophthalmological findings in patients from Copenhagen University Dermatology Clinics. A standard eye examination further included exophthalmometry, axial length and keratometry (IOLMaster), and horizontal eye muscle thickness (B-scan ultrasonography). Read More

Acta Neurol Scand 2018 Nov 2;138(5):388-393. Epub 2018 Jul 2.

Emergency and Urgency Care Service, Águilas, Murcia, Spain.

Objective: we aimed to evaluate the utility of transorbital ultrasonography (TOS) in optic nerve assessment and quantification of ON atrophy in MS patients, and to determine whether ON atrophy correlates with the disease duration and disability measured on the Kurtzke Expanded Disability Status Scale (EDSS).

Materials And Methods: Prospective, multicentre, blinded cohort study of 59 patients diagnosed with relapsing-remitting MS and 36 controls.

Results: When measured with TOS, the diameter of both the right (2. Read More

J Neuroimmunol 2018 Aug 28;321:83-91. Epub 2018 May 28.

Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Immunoglobulin against myelin oligodendrocyte glycoprotein (MOG-IgG) is a potential demyelinating disease-associated autoantibody. Whether clinical features of MOG antibody-associated demyelinating diseases change with age remains unclear.

Object: To investigate the different clinical features between pediatric-onset and adult-onset MOG-IgG-seropositive patients in a relatively large cohort. Read More

BMJ Case Rep 2018 Jun 28;2018. Epub 2018 Jun 28.

Department of Neurology, Washington University in Saint Louis School of Medicine, St Louis, Missouri, USA.

Tumefactive appearing lesions on brain imaging can cause a diagnostic dilemma. We report a middle-aged man who presented with right-sided optic neuritis. A brain MRI showed enhancement of the right optic nerve, and non-enhancing white matter lesions including a 3 cm right frontal lesion with adjacent gyral expansion. Read More

Indian J Ophthalmol 2018 07;66(7):895

Pediatric Ophthalmology and Strabismology Services, Narayana Nethralaya, Narayana Health City, Bengaluru, Karnataka, India.

Zhonghua Yi Xue Za Zhi 2018 Jun;98(21):1669-1673

Department of Dalian Medical University, Dalian 116044, China.

To study the clinical features of late-onset neuromyelitis optica spectrum disorders(LONMOSD). Twenty-eight patients with LONMOSD and fifty-one patients with early-onset neuromyelitis optica spectrum disorders(EONMOSD) hospitalized in Navy General Hospital from January 2014 to May 2017 were enrolled and were followed up by telephone or outpatient visiting. The clinical manifestations, laboratory examinations and imaging features of the two groups were compared. Read More

Zhonghua Yi Xue Za Zhi 2018 Jun;98(21):1658-1663

Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.

To analyze the clinical presentations of neuromyelitis optica spectrum disorders (NMOSD) with ultra-longitudinally extensive transverse myelitis (uLETM), in order to improve the diagnostic accuracy of this disorder. Twenty-two uLETM patients was recruited and retrospectively analyzed for general clinical characteristics, laboratory tests and MRI characteristics, as well as therapeutic. (1)The Male-to-female ratio was 1∶6. Read More

JMM Case Rep 2018 May 14;5(5):e005145. Epub 2018 Mar 14.

Laboratory of Neuroscience, University of Zulia, Maracaibo, Venezuela.

Introduction: Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. Read More

Surv Ophthalmol 2018 Nov - Dec;63(6):875-879. Epub 2018 May 31.

Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.

A 55-year-old man with a history of mantle cell lymphoma reported acute blurred vision in the right eye. Although initially diagnosed with acute retrobulbar optic neuritis, 3 weeks later retinal infiltrates and vitritis developed, but vitrectomy resulted negative for vitreoretinal lymphoma. Further investigation revealed a serology positive for syphilis. Read More

CNS Drugs 2018 Jul;32(7):661-672

Department of Ophthalmology, Faculty of Medicine, CHU de Reims, URCA, Reims, France.

Background: Chronic visual loss is a disabling feature in patients with multiple sclerosis (MS). It was recently shown that MD1003 (high-dose pharmaceutical-grade biotin or hdPB) may improve disability in patients with progressive MS.

Objective: The aim of this study was to evaluate whether MD1003 improves vision compared with placebo in MS patients with chronic visual loss. Read More

Jpn J Ophthalmol 2018 Jul 25;62(4):525-530. Epub 2018 May 25.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis.

Design: Retrospective observational study, clinical case series SUBJECTS AND METHODS: We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Read More

Jpn J Ophthalmol 2018 Jul 23;62(4):517-524. Epub 2018 May 23.

Department of Ophthalmology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: To investigate the clinical characteristics of Japanese patients with scleritis STUDY DESIGN: Retrospective study METHODS: The clinical records of 123 patients with scleritis, who presented to the University of Tokyo Hospital between January, 2004 and December, 2015, were retrospectively reviewed.

Results: The cohort comprised 55 men and 68 women (mean age, 57.8±16. Read More

BMJ Case Rep 2018 May 23;2018. Epub 2018 May 23.

Clinical Board: Medicine (Neuroscience), The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.

Rhomboencephalitis, at least in its acute phase, is often a severely disabling syndrome, and can be life threatening. A range of underlying conditions can lead to this clinical syndrome. Rapid diagnosis to initiate treatment early is key to a beneficial outcome. Read More

J Comput Assist Tomogr 2018 Jul/Aug;42(4):502-509

Departments of Radiology and.

Purpose: In clinical practice, acute optic neuritis (ON) associated with the development of neuromyelitis optica (NMO) after the first attack is often indistinguishable from that associated with multiple sclerosis (MS). We aimed to determine the optimal combination of features derived from conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging using readout-segmented echo-planar imaging (RESOLVE-DWI) for the differentiation of these conditions.

Materials And Methods: Orbital conventional MRI and RESOLVE-DWI were performed using a 3. Read More