690 results match your criteria Optic Nerve Glioma Imaging


[Intraosseous metastasis of K27-mutant glioma].

Arkh Patol 2021 ;83(3):40-44

Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia.

Glioma metastasis outside the central nervous system is a quite rare phenomenon. The disease in a young woman manifested itself as back pain and loss of vision in the left eye. Magnetic resonance imaging (MRI) revealed a tumor of the optic nerve; positron emission tomography showed multiple secondary bone changes. Read More

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Imaging of the Primary Visual Pathway based on Visual Deficits.

J Clin Imaging Sci 2021 7;11:19. Epub 2021 Apr 7.

Department of Radiology, Mayo Clinic, Jacksonville, Florida, United States.

Vision loss can occur due to a variety of etiologies along the primary visual pathway. Understanding the anatomic organization of the visual pathway, which spans the globe to the occipital cortex, can help tailor neuroimaging to identify the cause of visual dysfunction. In this review, relevant anatomy and optimization of computed tomography and magnetic resonance imaging techniques will be described. Read More

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Color-doppler Flow Imaging Might Help Diagnose Optic Nerve Glioma.

Ophthalmology 2021 Mar;128(3):392

Department of Neuro-Radiology, Foundation Adolphe de Rothschild Hospital, Paris, France.

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Results of Neuroimaging in Patients with Atypical Normal-Tension Glaucoma.

Biomed Res Int 2020 18;2020:9093206. Epub 2020 Aug 18.

Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Lublin, Poland.

Aim: The aim of the study was to determine the frequency of pathologies which can mimic normal-tension glaucoma (NTG), observed in neuroimaging of NTG patients, and to evaluate the frequency of pathologies in determined additional indications for neuroimaging. . The studied group consisted of 126 NTG patients who met at least one of the following criteria: unilateral NTG, damage in the visual field (VF) inconsistent with optic disc appearance, fast VF progression, worsening of visual acuity, predominant optic disc pallor rather than optic disc excavation, diagnosis under the age of 50, and scotoma in VF restricted by a vertical line. Read More

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Acute post-partum vision loss due to pilocytic astrocytoma.

Am J Ophthalmol Case Rep 2020 Dec 20;20:100897. Epub 2020 Aug 20.

TOC Eye and Face, 3705 Medical Parkway, Suite 120, Austin, TX, 78705, USA.

Purpose: We report an unusual case of a thirty-three-year-old woman who presented with acute unilateral vision loss following pregnancy and was ultimately discovered to have a pilocytic astrocytoma of the optic nerve.

Observations: A thirty-three-year-old previously healthy female presented one month following Caesarean section with unilateral vision loss. She was found to have significantly decreased visual acuity, an afferent pupil deficit, proptosis, optic nerve edema and choroidal folds. Read More

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December 2020

[Unusual tumor infiltration of the optic disc secondary to high-grade glioma].

J Fr Ophtalmol 2020 Oct 12;43(8):803-804. Epub 2020 Aug 12.

Service d'ophtalmologie A, hôpital des spécialités, CHU, université Mohammed V, Rabat, Maroc.

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October 2020

Minimally Invasive 360-Degree Approach to Intraconal Orbital Tumors.

Am J Ophthalmol 2021 04 30;224:301-309. Epub 2020 Jul 30.

National Institute of Oncology and Radiobiology, La Habana, Cuba.

Purpose: To evaluate clinically the efficacy of 360-degree minimally invasive endoscopic surgery in patients with orbital intraconal tumors.

Design: Retrospective interventional case series.

Methods: A series of consecutive patients with orbital intraconal tumors were treated with minimally invasive surgery using an endonasal endoscopic approach or an anterior endoscopic orbitotomy over a 5-year period between January 2015 and January 2020 at the National Institute of Oncology and Radiobiology of Cuba. Read More

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Proptosis due to intraorbital space-occupying lesions in children.

Graefes Arch Clin Exp Ophthalmol 2020 Nov 16;258(11):2541-2550. Epub 2020 Jul 16.

Krieger Eye Research Laboratory, Felsenstein Medical Research Center, 4941492, Petah Tikva, Israel.

Purpose: To report the 10-year experience of two tertiary medical centers with children presenting with proptosis due to an intraorbital space-occupying lesion.

Methods: Patients were identified by file review. Data were collected on demographics, findings on ophthalmologic and imaging evaluations, etiology, treatment, and outcome. Read More

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November 2020

NF1 optic pathway glioma: analyzing risk factors for visual outcome and indications to treat.

Neuro Oncol 2021 01;23(1):100-111

Department of Pediatrics, University of Padua, Padua, Italy.

Background: The aim of the project was to identify risk factors associated with visual progression and treatment indications in pediatric patients with neurofibromatosis type 1 associated optic pathway glioma (NF1-OPG).

Methods: A multidisciplinary expert group consisting of ophthalmologists, pediatric neuro-oncologists, neurofibromatosis specialists, and neuro-radiologists involved in therapy trials assembled a cohort of children with NF1-OPG from 6 European countries with complete clinical, imaging, and visual outcome datasets. Using methods developed during a consensus workshop, visual and imaging data were reviewed by the expert team and analyzed to identify associations between factors at diagnosis with visual and imaging outcomes. Read More

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January 2021

Microcystic Macular Edema in Optic Nerve Glioma.

Ophthalmology 2020 07;127(7):930

Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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Cavernous Hemangioma of the Chiasm and Left Optic Nerve.

Cureus 2020 May 12;12(5):e8068. Epub 2020 May 12.

Department of Neurosurgery, Shupyk National Medical Academy of Postgraduate Education, Kyiv, UKR.

Cavernous malformations (CMs) of the optic nerves, chiasm, and optic tract are very rare. This report describes a 26-year-old man who presented with recurring headaches, loss of vision in his left eye, and elevated blood pressure. After being diagnosed with glioma of the chiasm, he was referred to our department. Read More

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Comparison of direct measurement of intracranial pressures and presumptive clinical and magnetic resonance imaging indicators of intracranial hypertension in dogs with brain tumors.

J Vet Intern Med 2020 Jul 16;34(4):1514-1523. Epub 2020 May 16.

Veterinary and Comparative Neuro-Oncology Laboratory, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.

Background: Intracranial hypertension (ICH) is often presumptively diagnosed based on clinical or imaging findings. Clinical or imaging surrogates of ICH are not usually validated with reference standard direct intracranial pressure (dICP) recordings.

Hypotheses: Dogs with brain magnetic resonance imaging (MRI) or clinical features of presumed ICH would have higher dICP than dogs lacking those features. Read More

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Pretreatment Endocrine Disorders Due to Optic Pathway Gliomas in Pediatric Neurofibromatosis Type 1: Multicenter Study.

J Clin Endocrinol Metab 2020 06;105(6)

Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli studi della Campania "Luigi Vanvitelli", Naples, Italy.

Context: Up to 20% of children with neurofibromatosis type 1 (NF1) develop low-grade optic pathway gliomas (OPGs) that can result in endocrine dysfunction. Data on prevalence and type of endocrine disorders in NF1-related OPGs are scarce.

Objectives: The aim of the study was to determine the prevalence of endocrine dysfunctions in patients with NF1 and OPGs and to investigate predictive factors before oncological treatment. Read More

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Comparison of Dosimetric Gains Provided by Intensity-Modulated Radiotherapy, Volume-Modulated Arc Therapy, and Helical Tomotherapy for High-Grade Glioma.

Biomed Res Int 2020 18;2020:4258989. Epub 2020 Mar 18.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008.

Purpose: Because of the poor prognosis for high-grade glioma (HGG) patients, it is important to increase the dose of the tumor to improve the efficacy while minimizing the dose of organs at risk (OARs). Thus, we evaluated the potential dosimetric gains of helical tomotherapy (HT) versus intensity-modulated radiotherapy (IMRT) or volume-modulated arc therapy (VMAT) for high-grade glioma (HGG).

Methods: A total of 42 HGG patients were retrospectively selected who had undergone helical tomotherapy; then, IMRT and VMAT plans were generated and optimized for comparison after contouring crucial neuronal structures for neurogenesis and neurocognitive function. Read More

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January 2021

Optic pathway glioma with intraocular extension in a child with neurofibromatosis type-1.

J Fr Ophtalmol 2020 May 30;43(5):e179-e181. Epub 2020 Mar 30.

Oculoplastic Unit, Hospital Sant Joan de Déu, Passeig de Sant Joan de Déu, 2, Esplugues de Llobregat, 08950 Barcelona, Spain.

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Expanded transnasal approaches to the skull base in the Middle East: Where do we stand?

Ann Saudi Med 2020 Mar-Apr;40(2):94-104. Epub 2020 Apr 2.

From the Division of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Endoscopic transnasal surgery has gained rapid global acceptance over the last two decades. The growing literature and understanding of anterior skull base endoscopic anatomy, in addition to new dedicated endoscopic instruments and tools, have helped to expand the use of the transnasal route in skull base surgery.

Objective: Report our early experience in expanded endoscopic transnasal surgery (EETS) and approach to skull base neoplasms. Read More

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December 2020

3 Tesla MRI brain scanning under general anaesthesia in a paediatric 3 Tesla-compatible cochlear implant recipient, first reported case: Clinical considerations and implications for future practice.

Int J Pediatr Otorhinolaryngol 2020 Jun 21;133:110015. Epub 2020 Mar 21.

Department of Radiology, Perth Children's Hospital, Nedlands, Western Australia, Australia.

Objectives: To demonstrate the safety and feasibility of the first reported case of a 3 Tesla MRI scan in a paediatric 3 Tesla-compatible cochlear implant recipient under general anaesthesia.

Materials And Methods: A three-year-old child with bilateral optic pathway glioma treated with chemotherapy, who subsequently received a right sided 3 Tesla-compatible cochlear implant for sensorineural hearing loss was examined. The CI device chosen was implanted due to its purported MRI compatibility. Read More

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Acute angle plication of optic nerve glioma as a mechanism of rapidly progressive visual loss.

Orbit 2021 Feb 24;40(1):30-33. Epub 2020 Feb 24.

Department of Ophthalmology, Harkness Eye Institute, Columbia University , New York, New York, USA.

: The majority of pediatric patients with optic nerve gliomas (ONG) remain asymptomatic; however, a subset of patients suffer rapid, irreversible visual loss. The purpose of this study was to determine anatomic differences of ONG noted either by imaging or by intra-operative observation between patients with gradual visual dysfunction and those with rapid visual loss. : A retrospective review was performed in patients with visual loss secondary to ONG. Read More

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February 2021

Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I.

Eur J Ophthalmol 2021 Mar 18;31(2):698-703. Epub 2020 Feb 18.

Eye Clinic of Genoa, Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

Purpose: The purpose of the present study was to compare visual function assessment, visual evoked potential, and optical coherence tomography with measurement of retinal nerve fiber layer thickness for the diagnosis of optic pathway glioma in children with neurofibromatosis type 1.

Methods: This retrospective observational study included patients with neurofibromatosis type 1 who underwent brain magnetic resonance imaging scan, visual evoked potential study, and peripapillary retinal nerve fiber layer evaluation by optical coherence tomography. Patients were tested with pattern-reversal visual evoked potential and with flash visual evoked potential in case of poor cooperation. Read More

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Disconjugate Nystagmus in a Child With Chiasmal Glioma.

Pediatr Neurol 2020 03 30;104:70-71. Epub 2019 Nov 30.

Department of Ophthalmology, University Hospital of Larissa, Larissa, Greece.

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[MALIGNANT OPTIC GLIOMA OF ADULTHOOD].

Harefuah 2019 Nov;158(11):708-710

Department of Ophthalmology, Rabin Medical Center, Petah-Tikva, Israel.

Introduction: A 61-year-old man presented with acute painless optic neuropathy with resultant no light perception in his left eye. Neuro-ophthalmological examination, optical coherence tomography and fluorescein angiography did not reveal the etiology. Since the patient had a cardiac pacemaker, he underwent a CT scan with contrast of the brain and orbits, which was normal. Read More

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November 2019

Assessment of the visual pathways in patients with neurofibromatosis-1 by 3S-space technique with 3-Tesla MRI

Turk J Med Sci 2019 12 16;49(6):1626-1633. Epub 2019 Dec 16.

Background/aim/aim: We aimed to evaluate the size/tortuosity of the optic nerve (ON) and the dilatation of the ON sheath (ONS) in neurofibromatosis type 1 (NF-1) patients with 3T-MRI, and to assess the usefulness of 3D-SPACE in imaging the optic pathway, ON, and ONS in NF-1 patients.

Materials And Methods: Twenty consecutive NF-1 patients without optic pathway glioma (OPG) (Group 1), 16 consecutive NF-1 patients with OPG (Group 2), and 19 controls were included in this study. The thickness and tortuosity of the ON and the diameter of the ONS were measured on STIR and 3D-SPACE images. Read More

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December 2019

Development of a multidisciplinary clinic of neurofibromatosis type 1 and other neurocutaneous disorders in Greece. A 3-year experience.

Postgrad Med 2019 Sep 12;131(7):445-452. Epub 2019 Sep 12.

Special Unit of Pediatric Neurology, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Agia Sofia Children's Hospital , Athens , Greece.

Given the complexity of neurocutaneous syndromes, a multidisciplinary approach has been advocated in order to provide optimum care. Retrospective analysis of a cohort of 157 patients during a 3-year period, seen at a newly developed neurocutaneous clinic in a pediatric tertiary care hospital in Athens (Greece); and systematic chart review of the patients diagnosed with neurofibromatosis type 1 during this time period. The most frequent neurocutaneous syndromes were neurofibromatosis type 1 (NF1) in 89 patients and tuberous sclerosis complex in 17. Read More

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September 2019

Rare Case of Sporadic Malignant Optic Pathway Glioma in 71-Year-Old Woman.

World Neurosurg 2020 Jan 20;133:413-415. Epub 2019 Jul 20.

Department of Neurosurgery, Ulm University Hospital, Ulm, Germany.

A 71-year-old woman presented to our institution with a 2-week history of concentric bilateral left accentuated visual field loss. Examination of her eyes including funduscopy was normal. A gadolinium-enhanced magnetic resonance tomography showed contrast enhancement of the optic pathway in the T1-weighted sequence that included both optic nerves, the optic chiasm, and the left optic tract. Read More

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January 2020

Neurological manifestations of neurofibromatosis type 1: our experience.

Neurologia (Engl Ed) 2019 Jul 17. Epub 2019 Jul 17.

Departamento de Pediatría, Radiología y Medicina Física, Facultad de Medicina de Zaragoza, Universidad de Zaragoza, Zaragoza, España.

Introduction: Neurofibromatosis type 1 (NF1) is a progressive multisystem disorder following an autosomal dominant inheritance pattern that presents with multiple neurological manifestations.

Methods: We reviewed medical histories of patients with NF1 followed up at our hospital's paediatric neurology department from May 1990 to 31 December 2018. We collected data on neurological symptoms. Read More

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Early-onset stroke in two siblings with Neurofibromatosis type 1.

Eur J Med Genet 2019 Oct 4;62(10):103710. Epub 2019 Jul 4.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder, characterized by cafe-au-lait macules, benign neurofibromas as well as malignant peripheral nerve sheath tumours, freckling in the axillary or inguinal regions, optic glioma and Lisch nodules (iris hamartomas) and further manifestations like bone deformities etc. Additionally, NF1 patients are at increased risk of early-onset cerebrovascular diseases, the pathogenesis of which has not been clarified yet. Here we report the first case of two siblings with NF1 who suffered an acute ischemic stroke. Read More

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October 2019

Ga-NOTA-Aca-BBN(7-14) PET imaging of GRPR in children with optic pathway glioma.

Eur J Nucl Med Mol Imaging 2019 Sep 3;46(10):2152-2162. Epub 2019 Jul 3.

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

Purpose: Optic pathway glioma (OPG) is a rare neoplasm that arises predominantly during childhood. Its location in a sensitive region involving the optic pathways, onset in young patients and controversial therapy choice make the management of OPG a challenge in paediatric neuro-oncology. In this study we assessed gastrin-releasing peptide receptor (GRPR)-targeted positron emission tomography (PET) imaging in children with OPG, and the application of a PET/MRI imaging-guided surgery navigation platform. Read More

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September 2019

Current treatment of optic nerve gliomas.

Curr Opin Ophthalmol 2019 Sep;30(5):356-363

Division of Ophthalmology, The Children's Hospital of Philadelphia.

Purpose Of Review: Optic pathway gliomas are low-grade neoplasms that affect the precortical visual pathway of children and adolescents. They can affect the optic nerve, optic chiasm, optic tracts and radiations and can either be sporadic or associated with neurofibromatosis type one. Gliomas isolated to the optic nerve (ONG) represent a subgroup of optic pathway gliomas, and their treatment remains controversial. Read More

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September 2019

Infantile Optic Pathway Glioblastoma.

World Neurosurg 2019 Sep 31;129:172-175. Epub 2019 May 31.

Department of Neurosurgery, Royal Hobart Hospital, Hobart, Tasmania, Australia. Electronic address:

Background: Optic pathway gliomas and glioblastomas remain a rare entity within the infant population.

Case Description: We outline the case of a 6-month-old female who presented with failure to thrive, nystagmus and features of raised intracranial pressure. Subsequent magnetic resonance imaging demonstrated an infiltrating tumor radiating from the optic nerves bilaterally. Read More

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September 2019

Visual Function, Brain Imaging, and Physiological Factors in Children With Asymmetric Nystagmus due to Chiasmal Gliomas.

Pediatr Neurol 2019 08 28;97:30-37. Epub 2019 Mar 28.

Department of Ophthalmology, University of Washington, Seattle, Washington; Division of Ophthalmology, Roger H. Johnson Vision Clinic, Seattle Children's Hospital, Seattle, Washington.

Purpose: Asymmetric nystagmus can be an important presenting sign of optic pathway gliomas in young children. We investigated the causes of asymmetric nystagmus in children with chiasmal or suprasellar optic pathway gliomas compared with children with similar optic pathway gliomas and stable gaze.

Methods: Longitudinal magnetic resonance imaging before and after treatment, age-corrected visual acuity, ocular examinations, video-oculography, visual evoked potentials, and retinal nerve fiber layer thickness were retrospectively reviewed. Read More

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