671 results match your criteria Optic Nerve Glioma Imaging


Cavernous Hemangioma of the Chiasm and Left Optic Nerve.

Cureus 2020 May 12;12(5):e8068. Epub 2020 May 12.

Department of Neurosurgery, Shupyk National Medical Academy of Postgraduate Education, Kyiv, UKR.

Cavernous malformations (CMs) of the optic nerves, chiasm, and optic tract are very rare. This report describes a 26-year-old man who presented with recurring headaches, loss of vision in his left eye, and elevated blood pressure. After being diagnosed with glioma of the chiasm, he was referred to our department. Read More

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http://dx.doi.org/10.7759/cureus.8068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224585PMC

Comparison of direct measurement of intracranial pressures and presumptive clinical and magnetic resonance imaging indicators of intracranial hypertension in dogs with brain tumors.

J Vet Intern Med 2020 May 16. Epub 2020 May 16.

Veterinary and Comparative Neuro-Oncology Laboratory, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.

Background: Intracranial hypertension (ICH) is often presumptively diagnosed based on clinical or imaging findings. Clinical or imaging surrogates of ICH are not usually validated with reference standard direct intracranial pressure (dICP) recordings.

Hypotheses: Dogs with brain magnetic resonance imaging (MRI) or clinical features of presumed ICH would have higher dICP than dogs lacking those features. Read More

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http://dx.doi.org/10.1111/jvim.15802DOI Listing

Acute angle plication of optic nerve glioma as a mechanism of rapidly progressive visual loss.

Orbit 2020 Feb 24:1-4. Epub 2020 Feb 24.

Department of Ophthalmology, Harkness Eye Institute, Columbia University, New York, New York, USA.

: The majority of pediatric patients with optic nerve gliomas (ONG) remain asymptomatic; however, a subset of patients suffer rapid, irreversible visual loss. The purpose of this study was to determine anatomic differences of ONG noted either by imaging or by intra-operative observation between patients with gradual visual dysfunction and those with rapid visual loss.: A retrospective review was performed in patients with visual loss secondary to ONG. Read More

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http://dx.doi.org/10.1080/01676830.2020.1733027DOI Listing
February 2020

Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I.

Eur J Ophthalmol 2020 Feb 18:1120672120906989. Epub 2020 Feb 18.

Eye Clinic of Genoa, Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

Purpose: The purpose of the present study was to compare visual function assessment, visual evoked potential, and optical coherence tomography with measurement of retinal nerve fiber layer thickness for the diagnosis of optic pathway glioma in children with neurofibromatosis type 1.

Methods: This retrospective observational study included patients with neurofibromatosis type 1 who underwent brain magnetic resonance imaging scan, visual evoked potential study, and peripapillary retinal nerve fiber layer evaluation by optical coherence tomography. Patients were tested with pattern-reversal visual evoked potential and with flash visual evoked potential in case of poor cooperation. Read More

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http://dx.doi.org/10.1177/1120672120906989DOI Listing
February 2020

[MALIGNANT OPTIC GLIOMA OF ADULTHOOD].

Harefuah 2019 Nov;158(11):708-710

Department of Ophthalmology, Rabin Medical Center, Petah-Tikva, Israel.

Introduction: A 61-year-old man presented with acute painless optic neuropathy with resultant no light perception in his left eye. Neuro-ophthalmological examination, optical coherence tomography and fluorescein angiography did not reveal the etiology. Since the patient had a cardiac pacemaker, he underwent a CT scan with contrast of the brain and orbits, which was normal. Read More

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November 2019

Assessment of the visual pathways in patients with neurofibromatosis-1 by 3S-space technique with 3-Tesla MRI

Turk J Med Sci 2019 12 16;49(6):1626-1633. Epub 2019 Dec 16.

Background/aim/aim: We aimed to evaluate the size/tortuosity of the optic nerve (ON) and the dilatation of the ON sheath (ONS) in neurofibromatosis type 1 (NF-1) patients with 3T-MRI, and to assess the usefulness of 3D-SPACE in imaging the optic pathway, ON, and ONS in NF-1 patients.

Materials And Methods: Twenty consecutive NF-1 patients without optic pathway glioma (OPG) (Group 1), 16 consecutive NF-1 patients with OPG (Group 2), and 19 controls were included in this study. The thickness and tortuosity of the ON and the diameter of the ONS were measured on STIR and 3D-SPACE images. Read More

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http://dx.doi.org/10.3906/sag-1906-14DOI Listing
December 2019

Development of a multidisciplinary clinic of neurofibromatosis type 1 and other neurocutaneous disorders in Greece. A 3-year experience.

Postgrad Med 2019 Sep 12;131(7):445-452. Epub 2019 Sep 12.

Special Unit of Pediatric Neurology, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Agia Sofia Children's Hospital , Athens , Greece.

Given the complexity of neurocutaneous syndromes, a multidisciplinary approach has been advocated in order to provide optimum care. Retrospective analysis of a cohort of 157 patients during a 3-year period, seen at a newly developed neurocutaneous clinic in a pediatric tertiary care hospital in Athens (Greece); and systematic chart review of the patients diagnosed with neurofibromatosis type 1 during this time period. The most frequent neurocutaneous syndromes were neurofibromatosis type 1 (NF1) in 89 patients and tuberous sclerosis complex in 17. Read More

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http://dx.doi.org/10.1080/00325481.2019.1659708DOI Listing
September 2019
4 Reads

Rare Case of Sporadic Malignant Optic Pathway Glioma in 71-Year-Old Woman.

World Neurosurg 2020 Jan 20;133:413-415. Epub 2019 Jul 20.

Department of Neurosurgery, Ulm University Hospital, Ulm, Germany.

A 71-year-old woman presented to our institution with a 2-week history of concentric bilateral left accentuated visual field loss. Examination of her eyes including funduscopy was normal. A gadolinium-enhanced magnetic resonance tomography showed contrast enhancement of the optic pathway in the T1-weighted sequence that included both optic nerves, the optic chiasm, and the left optic tract. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.108DOI Listing
January 2020
5 Reads

Neurological manifestations of neurofibromatosis type 1: our experience.

Neurologia 2019 Jul 17. Epub 2019 Jul 17.

Departamento de Pediatría, Radiología y Medicina Física, Facultad de Medicina de Zaragoza, Universidad de Zaragoza, Zaragoza, España.

Introduction: Neurofibromatosis type 1 (NF1) is a progressive multisystem disorder following an autosomal dominant inheritance pattern that presents with multiple neurological manifestations.

Methods: We reviewed medical histories of patients with NF1 followed up at our hospital's paediatric neurology department from May 1990 to 31 December 2018. We collected data on neurological symptoms. Read More

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http://dx.doi.org/10.1016/j.nrl.2019.05.003DOI Listing
July 2019
7 Reads

Early-onset stroke in two siblings with Neurofibromatosis type 1.

Eur J Med Genet 2019 Oct 4;62(10):103710. Epub 2019 Jul 4.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder, characterized by cafe-au-lait macules, benign neurofibromas as well as malignant peripheral nerve sheath tumours, freckling in the axillary or inguinal regions, optic glioma and Lisch nodules (iris hamartomas) and further manifestations like bone deformities etc. Additionally, NF1 patients are at increased risk of early-onset cerebrovascular diseases, the pathogenesis of which has not been clarified yet. Here we report the first case of two siblings with NF1 who suffered an acute ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.103710DOI Listing
October 2019
1 Read

Current treatment of optic nerve gliomas.

Curr Opin Ophthalmol 2019 Sep;30(5):356-363

Division of Ophthalmology, The Children's Hospital of Philadelphia.

Purpose Of Review: Optic pathway gliomas are low-grade neoplasms that affect the precortical visual pathway of children and adolescents. They can affect the optic nerve, optic chiasm, optic tracts and radiations and can either be sporadic or associated with neurofibromatosis type one. Gliomas isolated to the optic nerve (ONG) represent a subgroup of optic pathway gliomas, and their treatment remains controversial. Read More

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http://Insights.ovid.com/crossref?an=00055735-201909000-0001
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http://dx.doi.org/10.1097/ICU.0000000000000587DOI Listing
September 2019
3 Reads

Infantile Optic Pathway Glioblastoma.

World Neurosurg 2019 Sep 31;129:172-175. Epub 2019 May 31.

Department of Neurosurgery, Royal Hobart Hospital, Hobart, Tasmania, Australia. Electronic address:

Background: Optic pathway gliomas and glioblastomas remain a rare entity within the infant population.

Case Description: We outline the case of a 6-month-old female who presented with failure to thrive, nystagmus and features of raised intracranial pressure. Subsequent magnetic resonance imaging demonstrated an infiltrating tumor radiating from the optic nerves bilaterally. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.05.236DOI Listing
September 2019
3 Reads

Visual Function, Brain Imaging, and Physiological Factors in Children With Asymmetric Nystagmus due to Chiasmal Gliomas.

Pediatr Neurol 2019 08 28;97:30-37. Epub 2019 Mar 28.

Department of Ophthalmology, University of Washington, Seattle, Washington; Division of Ophthalmology, Roger H. Johnson Vision Clinic, Seattle Children's Hospital, Seattle, Washington.

Purpose: Asymmetric nystagmus can be an important presenting sign of optic pathway gliomas in young children. We investigated the causes of asymmetric nystagmus in children with chiasmal or suprasellar optic pathway gliomas compared with children with similar optic pathway gliomas and stable gaze.

Methods: Longitudinal magnetic resonance imaging before and after treatment, age-corrected visual acuity, ocular examinations, video-oculography, visual evoked potentials, and retinal nerve fiber layer thickness were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.021DOI Listing
August 2019
6 Reads

Dural Ectasia of the Optic Nerve: A Rare Presentation in Neurofibromatosis Type I.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):349-351

Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Neurofibromatosis Type 1 (NF-1) is a common neurocutaneous syndrome with a characteristic spectrum of pathologies affecting the optic pathway. Optic pathway glioma and optic nerve meningioma are two such common afflictions of the optic nerve in NF-1. Dural ectasia of the optic nerve also known as optic nerve meningocele is a rare manifestation of optic nerve involvement in NF-1. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/349/254
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http://dx.doi.org/10.4103/jnrp.jnrp_232_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454956PMC
April 2019
27 Reads

Brain gliomas, hydrocephalus and idiopathic aqueduct stenosis in children with neurofibromatosis type 1.

Brain Dev 2019 Sep 15;41(8):678-690. Epub 2019 Apr 15.

Department of Neurosurgery, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.

Purpose: To evaluate the incidence and clinical importance of brain gliomas - optic pathway gliomas (OPGs) and especially gliomas outside the optic pathway (GOOP) for children with neurofibromatosis type 1 (NF1), additionally, to assess the causes of obstructive hydrocephalus in NF1 children with an emphasis on cases caused by idiopathic aqueduct stenosis.

Subjects And Methods: We analysed data from 285 NF1 children followed up on our department from 1990 to 2010 by the same examination battery.

Results: We have found OPGs in 77/285 (27%) children and GOOPs in 29/285 (10,2%) of NF1 children, of who 19 had OPG and GOOP together, so the total number of brain glioma was 87/285 (30,5%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183048
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http://dx.doi.org/10.1016/j.braindev.2019.04.003DOI Listing
September 2019
16 Reads
1.542 Impact Factor

Diagnostic performance of an unenhanced MRI exam for tumor follow-up of the optic pathway gliomas in children.

Neuroradiology 2019 Jun 23;61(6):711-720. Epub 2019 Mar 23.

Department of Pediatric Radiology, Pellegrin Children's Hospital, Place Amelie Raba-Leon, 33076, Bordeaux, France.

Purpose: Contrast-enhanced MRI (MRI + C) is considered as mandatory for brain tumors follow-up, but gadolinium brain depositions in relation with repeated injections have been reported. The aim of our work was to evaluate the diagnostic performance of an unenhanced MRI examination for the follow-up of optic pathway gliomas (OPG) in children.

Methods: Seventeen patients (with/without NF1) were selected from 2001 to 2017, with at least 5 MRI + C brain follow-up examinations. Read More

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http://link.springer.com/10.1007/s00234-019-02198-w
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http://dx.doi.org/10.1007/s00234-019-02198-wDOI Listing
June 2019
26 Reads

Diagnostic accuracy of neuroimaging in pediatric optic chiasm/sellar/suprasellar tumors.

Pediatr Blood Cancer 2019 06 8;66(6):e27680. Epub 2019 Mar 8.

Morgan Adams Foundation Pediatric Brain Tumor Research Foundation, Aurora, Colorado.

Preoperative diagnosis for tumors arising in the optic chiasm/sellar/suprasellar region in children is helpful to determine surgical necessity and approach, given the high operative risk in this area. We evaluated the ability to differentiate tumor type by preoperative neuroimaging. Thirty-eight of 53 tumors were correctly diagnosed by neuroimaging based on final pathologic diagnosis (prediction accuracy 72%). Read More

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http://dx.doi.org/10.1002/pbc.27680DOI Listing
June 2019
11 Reads

Neurofibromatosis Type 1: Description of a Novel Diagnostic Scoring System in Pediatric Optic Nerve Glioma.

AJR Am J Roentgenol 2019 04 11;212(4):892-898. Epub 2019 Feb 11.

1 Department of Medical Imaging, Montreal Children's Hospital, McGill University, 1001 Decarie Blvd, Rm B02.7005, Montreal, QC H4A 3J1, Canada.

Objective: Neurofibromatosis type 1 (NF1) is a multisystemic genetic disease in which patients develop benign tumors including optic nerve gliomas (ONG). Optic nerve thickening and tortuosity are radiologic markers of tumors but can also be present in children with NF1 who do not have gliomas, thus complicating screening and diagnosis. We undertook this study to retrospectively determine quantitative and qualitative diagnostic criteria using MRI of the orbits for ONG in children with NF1. Read More

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http://dx.doi.org/10.2214/AJR.18.20044DOI Listing
April 2019
6 Reads

Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1.

Anticancer Res 2019 Feb;39(2):827-831

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

This report describes the diagnosis and treatment of a 27-year-old patient with neurofibromatosis 1 (NF1) and late progression of a pre-existing optic pathway glioma (OPG) that caused significant reduction in vision. OPG is one of the diagnostic criteria for establishing the diagnosis of NF1. Most common findings of NF1 are café-au-lait spots, axillary and inguinal freckling of the skin, iris hamartoma (Lisch nodules), and tumors of the central nervous system and peripheral nerves. Read More

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http://dx.doi.org/10.21873/anticanres.13181DOI Listing
February 2019
10 Reads

Retinal microvascular abnormalities in neurofibromatosis type 1.

Br J Ophthalmol 2019 11 31;103(11):1590-1594. Epub 2019 Jan 31.

Department of Dermatology, Sapienza University of Rome, Rome, Italy.

Purpose: The aim of this study was to provide a classification of the different retinal vascular arrangements in neurofibromatosis 1 (NF1), with appropriate qualitative and quantitative information.

Methods: This study was conducted on 334 consecutive patients with NF1 and 106 sex-matched and age-matched healthy control subjects. Each patient underwent a comprehensive ophthalmological examination inclusive of near-infrared reflectance retinography by using the spectral domain Optical coherence tomography (OCT), a complete dermatological examination and 1. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313002DOI Listing
November 2019
7 Reads

Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1.

Neuroradiology 2019 Apr 25;61(4):431-441. Epub 2019 Jan 25.

Department of Pediatrics, Section of Hematology/Oncology, Indiana University School of Medicine, Indiana, IN, USA.

Purpose: Diffusion tensor imaging (DTI) may be helpful in assessing optic pathway integrity as a marker for treatment in neurofibromatosis type 1 (NF1) patients with optic gliomas (OG). However, susceptibility artifacts are common in typical single-shot echo planar imaging (ssDTI). A readout-segmented multi-shot EPI technique (rsDTI) was utilized to minimize susceptibility distortions of the skull base and improve quantitative metrics. Read More

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http://dx.doi.org/10.1007/s00234-019-02164-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213040PMC
April 2019
2 Reads

Use of Optical Coherence Tomography to Detect Retinal Nerve Fiber Loss in Children With Optic Pathway Glioma.

Front Neurol 2018 20;9:1102. Epub 2018 Dec 20.

Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Petah Tikva, Israel.

Optic pathway glioma (OPG) presents in childhood and can cause significant morbidity and visual loss. Magnetic resonance imaging (MRI) is the current imaging modality of choice for evaluation of OPG progression, but it is a relatively limited resource often requiring sedation in the pediatric age group. Additionally, OPG progression on MRI does not always correlate with clinical progression. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01102
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http://dx.doi.org/10.3389/fneur.2018.01102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306407PMC
December 2018
24 Reads

Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion.

Radiol Case Rep 2019 Feb 13;14(2):226-229. Epub 2018 Nov 13.

Division of Neuroradiology, Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Room S-047, Stanford, CA 94305-5105, USA.

Malignant optic glioma presents a clinical and diagnostic challenge, as early imaging findings overlap with other more common causes of optic nerve enhancement and enlargement, potentially leading to delay in diagnosis. This rare diagnosis carries an extremely poor prognosis, with death usually occurring within 1 year. We present a case of malignant optic glioma that was initially diagnosed as optic neuritis and central retinal vein occlusion, and we emphasize the importance of serial imaging and definitive biopsy to promote early diagnosis and treatment of this entity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183031
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http://dx.doi.org/10.1016/j.radcr.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234704PMC
February 2019
31 Reads

Prevalence of Strabismus Among Children With Neurofibromatosis Type 1 Disease With and Without Optic Pathway Glioma.

J Pediatr Ophthalmol Strabismus 2019 Jan 26;56(1):19-22. Epub 2018 Oct 26.

Purpose: To evaluate the prevalence of strabismus in neurofibromatosis type 1 (NF-1) by comparing children with normal neuroimaging to those with optic pathway glioma.

Methods: A retrospective data collection of all children with NF-1 with neuroimaging studies examined at a single medical center between 2000 and 2016.

Results: Of the 198 children with NF-1 reviewed, 109 (55%) were male, 121 (61%) had normal neuroimaging, and 77 (39%) had an optic pathway glioma. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01913913-2018
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http://dx.doi.org/10.3928/01913913-20180925-02DOI Listing
January 2019
3 Reads

Endoscopic transnasal resection of optic pathway pilocytic astrocytoma.

Childs Nerv Syst 2019 01 18;35(1):73-81. Epub 2018 Oct 18.

Department of Neurosurgery, King Saud University, Riyadh, Saudi Arabia.

Purpose: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely limited, and no such reports exist on its utility for pediatric OPGs. Read More

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http://link.springer.com/10.1007/s00381-018-3994-4
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http://dx.doi.org/10.1007/s00381-018-3994-4DOI Listing
January 2019
44 Reads
1.163 Impact Factor

Correlation of peripapillary retinal nerve fibre layer thickness with visual acuity in paediatric patients affected by optic pathway glioma.

Acta Ophthalmol 2018 Dec 3;96(8):e1004-e1009. Epub 2018 Oct 3.

Department of Ophthalmology, University of Padova, Padova, Italy.

Purpose: To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness, measured by spectral-domain optical coherence tomography (SD-OCT), as a surrogate of visual function in a population of paediatric patients affected by optic pathway glioma (OPG) associated with neurofibromatosis type 1 (NF1).

Methods: A total of 38 paediatric patients (66 eyes) affected by MRI-proven OPG were included. Each patient underwent complete ophthalmological examination, including age-appropriate visual acuity (VA) assessment and RNFL analysis by SD-OCT. Read More

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http://dx.doi.org/10.1111/aos.13803DOI Listing
December 2018
27 Reads

Ophthalmological examination in neurofibromatosis type 1: a long-term retrospective analysis.

Acta Ophthalmol 2018 Dec 26;96(8):e1044-e1046. Epub 2018 Sep 26.

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/aos.13831DOI Listing
December 2018
4 Reads

Optic Pathway Gliomas in Neurofibromatosis Type 1: Imaging and Monitoring.

Authors:
Shannon J Beres

Int Ophthalmol Clin Fall 2018;58(4):97-112

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http://dx.doi.org/10.1097/IIO.0000000000000241DOI Listing
March 2019
11 Reads

Monitoring optic chiasmatic-hypothalamic glioma volumetric changes by MRI in children under clinical surveillance or chemotherapy.

Childs Nerv Syst 2019 01 4;35(1):63-72. Epub 2018 Aug 4.

Division of Radiology, Department of Clinics, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil.

Purpose: Optic pathway gliomas represent 5% of pediatric brain tumors and are typically low-grade lesions. Because of their unpredictable clinical course, adequate treatment approaches have been controversial, involving surveillance, surgery, chemotherapy, and radiotherapy. In this study, we use volumetric imaging to compare evolution of optic chiasmatic-hypothalamic gliomas (OCHG) treated with and without chemotherapy, analyzing tumor volume variation during the overall period. Read More

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http://dx.doi.org/10.1007/s00381-018-3904-9DOI Listing
January 2019
47 Reads

Endovascular glue embolization of a radiation-induced lenticulostriate artery pseudoaneurysm in a pediatric patient with optic pathway glioma: Case report and review of literature.

Interv Neuroradiol 2018 Oct 31;24(5):499-508. Epub 2018 May 31.

3 Department of Paediatric Neurosurgery, Children's Hospital of Eastern Ontario University of Ottawa, Ottawa, Canada.

Radiation-associated vascular changes most commonly present in the form of stenosis, thrombosis and occlusion. However, development of intracranial aneurysms secondary to radiation is far less common and often manifests with rupture. These aneurysms are difficult to treat and associated with high morbidity and mortality when ruptured compared with saccular aneurysms unrelated to radiation treatment. Read More

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http://dx.doi.org/10.1177/1591019918773303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116129PMC
October 2018
39 Reads

Surveillance magnetic resonance imaging for isolated optic pathway gliomas: is gadolinium necessary?

Pediatr Radiol 2018 09 22;48(10):1472-1484. Epub 2018 May 22.

Department of Radiology,, University of Washington,, Seattle, WA, USA.

Background: Pediatric optic pathway gliomas are typically indolent but have a variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced MRI examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast agents. Read More

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http://dx.doi.org/10.1007/s00247-018-4154-4DOI Listing
September 2018
38 Reads

Optic Nerve Volvulus.

Ophthalmology 2018 06;125(6):877

Mayo Clinic Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.ophtha.2018.03.017DOI Listing
June 2018
2 Reads

Serial MRIs provide novel insight into natural history of optic pathway gliomas in patients with neurofibromatosis 1.

Orphanet J Rare Dis 2018 04 23;13(1):62. Epub 2018 Apr 23.

Department of Medical Genetics, BC Children's Hospital, University of British Columbia, 4480 Oak Street, Vancouver, Canada.

Background: Optic pathway gliomas (OPGs) are present in 20% of children with neurofibromatosis 1 (NF1) but are less frequently observed in adults. Our goal was to determine the natural history of OPGs in children and adults with NF1.

Results: We analyzed the features of OPGs and other intracranial lesions on 1775 head MRI scans of 562 unselected adults and children with NF1 collected between 2003 and 2015. Read More

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http://dx.doi.org/10.1186/s13023-018-0811-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913802PMC
April 2018
30 Reads

2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.

Am J Med Genet A 2018 05;176(5):1258-1269

Hereditary Cancer Group, The Institute for Health Science Research Germans Trias i Pujol (IGTP)-PMPPC, Barcelona, Spain.

Organized and hosted by the Children's Tumor Foundation (CTF), the Neurofibromatosis (NF) conference is the premier annual gathering for clinicians and researchers interested in neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN). The 2016 edition constituted a blend of clinical and basic aspects of NF research that helped in clarifying different advances in the field. The incorporation of next generation sequencing is changing the way genetic diagnostics is performed for NF and related disorders, providing solutions to problems like genetic heterogeneity, overlapping clinical manifestations, or the presence of mosaicism. Read More

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http://dx.doi.org/10.1002/ajmg.a.38675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918269PMC
May 2018
32 Reads

A giant dermoid cyst of the orbit.

Orbit 2019 Apr 28;38(2):158-161. Epub 2018 Mar 28.

a Orbit, Oculoplasty, Reconstructive & Aesthetic Services , Sankara Nethralaya, Medical Research Foundation , Chennai , India.

To describe a unique case of a non-germinomatous germ cell tumor, a giant orbital dermoid, present in adulthood. A 31-year-old male presented in our clinic with gradual, painless, progressive proptosis in the left eye since 28 years associated with gradual loss of vision. The left eye showed gross proptosis. Read More

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http://dx.doi.org/10.1080/01676830.2018.1457060DOI Listing
April 2019
38 Reads

Endoscopic Transsphenoidal Surgery for an Adult Patient With Giant Exophytic Chiasmatic/Hypothalamic Glioma.

J Craniofac Surg 2018 Jul;29(5):e499-e502

Department of Neurosurgery, Zhucheng People's Hospital, Zhucheng City, China.

Optic pathway hypothalamic gliomas are intrinsic low-grade gliomas involving the optic nerve, chiasm, optic tract, and hypothalamus. The rarity of these tumors and their unpredictable course make assessment and standardization of treatment modalities difficult. Tumor debulking via various transcranial approaches was considered to be effective at controlling tumor growth, but with high rates of severe surgery-related complications. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004543DOI Listing
July 2018
11 Reads

Multicentric Glioblastoma Multiforme Mimicking Optic Neuritis.

Neuroophthalmology 2018 Apr 2;42(2):112-116. Epub 2017 Aug 2.

Department of Radiology, Vittorio Veneto Hospital, Vittorio Veneto, Italy.

A 49-year-old previously healthy woman presented with acute painless visual loss in the right eye, a right relative afferent pupillary defect, and a normal fundus examination. She was diagnosed with retrobulbar "optic neuritis" and given a course of intravenous steroids. Despite treatment, however, she continued to lose vision and serial visual field testing confirmed a junctional scotoma in the fellow eye. Read More

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http://dx.doi.org/10.1080/01658107.2017.1350194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858864PMC
April 2018
46 Reads

Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity.

Neuroimage Clin 2018 11;17:541-548. Epub 2017 Oct 11.

Developmental Imaging & Biophysics Section, University College London Great Ormond Street Institute of Child Health, London, UK.

Background: Radiological biomarkers which correlate with visual function are needed to improve the clinical management of optic pathway glioma (OPG) patients. Currently, these are not available using conventional magnetic resonance imaging (MRI) sequences. The aim of this study was to determine whether diffusion MRI could be used to delineate the entire optic pathway in OPG patients, and provide imaging biomarkers within this pathway which correlate with a patient's visual acuity (VA). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582173025
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http://dx.doi.org/10.1016/j.nicl.2017.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842647PMC
February 2019
31 Reads

Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis: Retrospective Characterization and Analysis of Outcomes.

J Child Neurol 2018 05 5;33(6):375-382. Epub 2018 Mar 5.

1 Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

Isolated optic nerve glioma is a rare tumor with no consensus for the best therapeutic approach. Therefore, tumor control and preservation of visual function remain a challenge. In this retrospective study, we describe our experience over 30 years in a single-institutional cohort of children with isolated optic nerve glioma, focusing on treatments and visual outcomes. Read More

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http://dx.doi.org/10.1177/0883073818758737DOI Listing
May 2018
55 Reads

Moya-Moya syndrome after cranial radiation for optic glioma with NF1. Case report and literature review of syndromic cases.

Neurochirurgie 2018 Mar 21;64(1):63-67. Epub 2018 Feb 21.

Service de neurochirurgie, CHRU de Besançon, université Bourgogne-Franche-Comté, 3, boulevard Alexandre-Fleming, 25030 Besançon, France.

Introduction: Moya-Moya angiopathy is a neurovascular disease that predisposes to ischemic or hemorrhagic strokes. It is generated by a steno-occlusion of the terminal portion of the internal carotid arteries, which induces the development of abnormal neovessels in the deep regions of the brain. Some pathologies such as sickle cell disease, Down syndrome or Graves' disease may be associated with Moya-Moya angiopathy. Read More

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http://dx.doi.org/10.1016/j.neuchi.2017.11.004DOI Listing
March 2018
3 Reads

Optic pathway-hypothalamic glioma hemorrhage: a series of 9 patients and review of the literature.

J Neurosurg 2018 12;129(6):1407-1415

1Department of Pediatric Neurosurgery, International Israel Neurofibromatosis Center (IINFC), Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv University, Israel.

OBJECTIVEHemorrhage (also known as apoplexy) in optic pathway gliomas (OPGs) is rare. Because of the variable presentations and low incidence of OPG hemorrhages, little is known about their clinical course and the best treatment options. The aim of this work was to review risk factors, clinical course, and treatment strategies of optic glioma hemorrhages in the largest possible number of cases. Read More

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http://dx.doi.org/10.3171/2017.8.JNS163085DOI Listing
December 2018
20 Reads

Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases.

Childs Nerv Syst 2018 04 1;34(4):605-610. Epub 2018 Feb 1.

Department of Oncology, MS 260, Division of Neuro-Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

Background: Despite appropriate therapeutic interventions, progressive optic pathway glioma (OPG) in children may result in loss of vision and other neurologic morbidities. Molecularly targeted therapy against the MAP kinase pathway holds promise in improving outcomes while resulting in lower treatment-related toxicities. We report two children with refractory OPG who had a substantial and early reversal of their neurologic deficits and an impressive imaging response of their tumor to BRAFV600E inhibition therapy. Read More

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http://dx.doi.org/10.1007/s00381-018-3739-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857244PMC
April 2018
19 Reads

Awake Surgery for Gliomas within the Right Inferior Parietal Lobule: New Insights into the Functional Connectivity Gained from Stimulation Mapping and Surgical Implications.

World Neurosurg 2018 Apr 31;112:e393-e406. Epub 2018 Jan 31.

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France; Institute for Neuroscience of Montpellier, INSERM 1051, Team "Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors", Saint Eloi Hospital, Montpellier University Medical Center, Montpellier, France; University of Montpellier, Montpellier, France. Electronic address:

Objective: Little is known about the functional role of the white matter connections running within and around the right inferior parietal lobule (IPL). We used direct electrostimulation during awake surgery to investigate this connectivity and to avoid permanent deficit after resection for right IPL gliomas.

Methods: We reviewed patients who underwent awake mapping for a glioma involving the right IPL. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.01.053DOI Listing
April 2018
3 Reads

Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1.

J Neurol Surg A Cent Eur Neurosurg 2018 May 2;79(3):268-272. Epub 2018 Jan 2.

Department of Neurosurgery, UMHAT "St. Ivan Rilski", Medical University, Sofia, Bulgaria.

Optic nerve glioma (ONG) is associated in 10% of patients with neurofibromatosis (NF) type 1. To date no consensus has been reached regarding the therapeutic approach and prevention of visual impairment in these patients. Reports in the literature vary from a conservative approach (observation) to the use of single treatment modalities or multimodality protocols of surgical removal, radiotherapy, and/or chemotherapy. Read More

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http://dx.doi.org/10.1055/s-0037-1608869DOI Listing
May 2018
19 Reads

Vascular stenosis in a child with visual pathway glioma treated with bevacizumab: a case report and review of literature.

Childs Nerv Syst 2018 04 16;34(4):781-785. Epub 2017 Dec 16.

Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.

Background: Bevacizumab (BVZ) is a vascular endothelial growth factor inhibitor that has been widely accepted since its introduction into the cancer pharmacopoeia. Anecdotal reports suggested improvements in vision in children with visual pathway glioma.

Case Presentation: We report a boy with visual pathway glioma whose vision had deteriorated significantly on vincristine and carboplatin, to the point that he was registered blind. Read More

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http://dx.doi.org/10.1007/s00381-017-3676-7DOI Listing
April 2018
9 Reads

Analysis of Survival Prognosis for Children with Symptomatic Optic Pathway Gliomas Who Received Surgery.

World Neurosurg 2018 Jan 3;109:e1-e15. Epub 2017 Oct 3.

Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Center for Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory for Brain Tumor, Beijing, People's Republic of China. Electronic address:

Objective: The feasibility and prognosis of surgical treatment for children with optic pathway gliomas (OPGs) is controversial. Therefore this study attempted to evaluate the effects of surgery and discuss prognostic factors related to the survival of children with symptomatic OPGs.

Materials And Methods: One-hundred twenty-five children diagnosed with OPGs underwent surgery in the Department of Neurosurgery, Beijing Tiantan Hospital from 2003-2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750173166
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http://dx.doi.org/10.1016/j.wneu.2017.09.144DOI Listing
January 2018
27 Reads

Isolated optic nerve gliomas: a multicenter historical cohort study.

J Neurosurg Pediatr 2017 Dec 6;20(6):549-555. Epub 2017 Oct 6.

1The Gilbert Israeli Neurofibromatosis Center, Dana Children's Hospital.

OBJECTIVE Isolated optic nerve gliomas (IONGs) constitute a rare subgroup of optic pathway gliomas (OPGs). Due to the rarity of this condition and the difficulty in differentiating IONGs from other types of OPGs in most clinical series, little is known about these tumors. Currently, due to lack of evidence, they are managed the same as any other OPG. Read More

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http://dx.doi.org/10.3171/2017.6.PEDS17107DOI Listing
December 2017
24 Reads

Optic Pathway Gliomas Secondary to Neurofibromatosis Type 1.

Semin Pediatr Neurol 2017 05 10;24(2):92-99. Epub 2017 Apr 10.

Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Children with neurofibromatosis type 1 frequently manifest optic pathway gliomas-low-grade gliomas intrinsic to the visual pathway. This review describes the molecular and genetic mechanisms driving optic pathway gliomas as well as the clinical symptoms of this relatively common genetic condition. Recommendations for clinical management and descriptions of the newest imaging techniques are discussed. Read More

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http://dx.doi.org/10.1016/j.spen.2017.04.006DOI Listing
May 2017
22 Reads

Optical coherence tomography as a marker of vision in children with optic pathway gliomas.

Childs Nerv Syst 2018 01 26;34(1):51-60. Epub 2017 Aug 26.

Department of Neurosurgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Purpose: Optic pathway gliomas (OPG) represent an important cause of visual loss in pediatric population. The indication of treatment is based on clinical or neuroimaging progression. Visual acuity loss is the most important symptom of disease progression, but children with OPG are frequently unable to complete the testing of visual function. Read More

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http://dx.doi.org/10.1007/s00381-017-3578-8DOI Listing
January 2018
82 Reads

Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.

J Neuroophthalmol 2017 09;37 Suppl 1:S23-S32

Cancer and Blood Diseases Institute (PMKdB), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics (PMKdB), University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Oncology (MJF), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics (MJF), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Neuro-Ophthalmology Service (GTL, RAA), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurology and Ophthalmology (GTL, RAA), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Neurofibromatosis Center and Department of Neurology (DHG), Washington University, St. Louis, Missouri; Department of Pediatrics (RL), Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Neurofibromatosis Centre, Department of Neurology (REF), Guy's and St. Thomas' NHS Foundation Trust; and Department of Clinical Neuroscience (REF), King's College, London, United Kingdom.

Optic pathway gliomas (OPGs) occur in 15%-20% of children with neurofibromatosis type 1 (NF1), leading to visual deficits in fewer than half of these individuals. The goal of chemotherapy is to preserve vision, but vision loss in NF1-associated OPG can be unpredictable. Determining which child would benefit from chemotherapy and, equally important, which child is better observed without treatment can be difficult. Read More

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http://Insights.ovid.com/crossref?an=00041327-201709001-0000
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http://dx.doi.org/10.1097/WNO.0000000000000550DOI Listing
September 2017
53 Reads