645 results match your criteria Optic Nerve Glioma Imaging


Neurofibromatosis Type 1: Description of a Novel Diagnostic Scoring System in Pediatric Optic Nerve Glioma.

AJR Am J Roentgenol 2019 Apr 11;212(4):892-898. Epub 2019 Feb 11.

1 Department of Medical Imaging, Montreal Children's Hospital, McGill University, 1001 Decarie Blvd, Rm B02.7005, Montreal, QC H4A 3J1, Canada.

Objective: Neurofibromatosis type 1 (NF1) is a multisystemic genetic disease in which patients develop benign tumors including optic nerve gliomas (ONG). Optic nerve thickening and tortuosity are radiologic markers of tumors but can also be present in children with NF1 who do not have gliomas, thus complicating screening and diagnosis. We undertook this study to retrospectively determine quantitative and qualitative diagnostic criteria using MRI of the orbits for ONG in children with NF1. Read More

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http://dx.doi.org/10.2214/AJR.18.20044DOI Listing
April 2019
2 Reads

Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1.

Anticancer Res 2019 Feb;39(2):827-831

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

This report describes the diagnosis and treatment of a 27-year-old patient with neurofibromatosis 1 (NF1) and late progression of a pre-existing optic pathway glioma (OPG) that caused significant reduction in vision. OPG is one of the diagnostic criteria for establishing the diagnosis of NF1. Most common findings of NF1 are café-au-lait spots, axillary and inguinal freckling of the skin, iris hamartoma (Lisch nodules), and tumors of the central nervous system and peripheral nerves. Read More

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http://dx.doi.org/10.21873/anticanres.13181DOI Listing
February 2019
4 Reads

Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1.

Neuroradiology 2019 Apr 25;61(4):431-441. Epub 2019 Jan 25.

Department of Pediatrics, Section of Hematology/Oncology, Indiana University School of Medicine, Indiana, IN, USA.

Purpose: Diffusion tensor imaging (DTI) may be helpful in assessing optic pathway integrity as a marker for treatment in neurofibromatosis type 1 (NF1) patients with optic gliomas (OG). However, susceptibility artifacts are common in typical single-shot echo planar imaging (ssDTI). A readout-segmented multi-shot EPI technique (rsDTI) was utilized to minimize susceptibility distortions of the skull base and improve quantitative metrics. Read More

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http://dx.doi.org/10.1007/s00234-019-02164-6DOI Listing

Use of Optical Coherence Tomography to Detect Retinal Nerve Fiber Loss in Children With Optic Pathway Glioma.

Front Neurol 2018 20;9:1102. Epub 2018 Dec 20.

Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Petah Tikva, Israel.

Optic pathway glioma (OPG) presents in childhood and can cause significant morbidity and visual loss. Magnetic resonance imaging (MRI) is the current imaging modality of choice for evaluation of OPG progression, but it is a relatively limited resource often requiring sedation in the pediatric age group. Additionally, OPG progression on MRI does not always correlate with clinical progression. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01102
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http://dx.doi.org/10.3389/fneur.2018.01102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306407PMC
December 2018
7 Reads

Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion.

Radiol Case Rep 2019 Feb 13;14(2):226-229. Epub 2018 Nov 13.

Division of Neuroradiology, Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Room S-047, Stanford, CA 94305-5105, USA.

Malignant optic glioma presents a clinical and diagnostic challenge, as early imaging findings overlap with other more common causes of optic nerve enhancement and enlargement, potentially leading to delay in diagnosis. This rare diagnosis carries an extremely poor prognosis, with death usually occurring within 1 year. We present a case of malignant optic glioma that was initially diagnosed as optic neuritis and central retinal vein occlusion, and we emphasize the importance of serial imaging and definitive biopsy to promote early diagnosis and treatment of this entity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183031
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http://dx.doi.org/10.1016/j.radcr.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234704PMC
February 2019
14 Reads

Prevalence of Strabismus Among Children With Neurofibromatosis Type 1 Disease With and Without Optic Pathway Glioma.

J Pediatr Ophthalmol Strabismus 2019 Jan 26;56(1):19-22. Epub 2018 Oct 26.

Purpose: To evaluate the prevalence of strabismus in neurofibromatosis type 1 (NF-1) by comparing children with normal neuroimaging to those with optic pathway glioma.

Methods: A retrospective data collection of all children with NF-1 with neuroimaging studies examined at a single medical center between 2000 and 2016.

Results: Of the 198 children with NF-1 reviewed, 109 (55%) were male, 121 (61%) had normal neuroimaging, and 77 (39%) had an optic pathway glioma. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01913913-2018
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http://dx.doi.org/10.3928/01913913-20180925-02DOI Listing
January 2019
2 Reads

Correlation of peripapillary retinal nerve fibre layer thickness with visual acuity in paediatric patients affected by optic pathway glioma.

Acta Ophthalmol 2018 Dec 3;96(8):e1004-e1009. Epub 2018 Oct 3.

Department of Ophthalmology, University of Padova, Padova, Italy.

Purpose: To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness, measured by spectral-domain optical coherence tomography (SD-OCT), as a surrogate of visual function in a population of paediatric patients affected by optic pathway glioma (OPG) associated with neurofibromatosis type 1 (NF1).

Methods: A total of 38 paediatric patients (66 eyes) affected by MRI-proven OPG were included. Each patient underwent complete ophthalmological examination, including age-appropriate visual acuity (VA) assessment and RNFL analysis by SD-OCT. Read More

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http://dx.doi.org/10.1111/aos.13803DOI Listing
December 2018
3 Reads

Ophthalmological examination in neurofibromatosis type 1: a long-term retrospective analysis.

Acta Ophthalmol 2018 Dec 26;96(8):e1044-e1046. Epub 2018 Sep 26.

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/aos.13831DOI Listing
December 2018

Optic Pathway Gliomas in Neurofibromatosis Type 1: Imaging and Monitoring.

Authors:
Shannon J Beres

Int Ophthalmol Clin Fall 2018;58(4):97-112

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http://dx.doi.org/10.1097/IIO.0000000000000241DOI Listing
March 2019
1 Read

Endovascular glue embolization of a radiation-induced lenticulostriate artery pseudoaneurysm in a pediatric patient with optic pathway glioma: Case report and review of literature.

Interv Neuroradiol 2018 Oct 31;24(5):499-508. Epub 2018 May 31.

3 Department of Paediatric Neurosurgery, Children's Hospital of Eastern Ontario University of Ottawa, Ottawa, Canada.

Radiation-associated vascular changes most commonly present in the form of stenosis, thrombosis and occlusion. However, development of intracranial aneurysms secondary to radiation is far less common and often manifests with rupture. These aneurysms are difficult to treat and associated with high morbidity and mortality when ruptured compared with saccular aneurysms unrelated to radiation treatment. Read More

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http://dx.doi.org/10.1177/1591019918773303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116129PMC
October 2018
23 Reads

Surveillance magnetic resonance imaging for isolated optic pathway gliomas: is gadolinium necessary?

Pediatr Radiol 2018 09 22;48(10):1472-1484. Epub 2018 May 22.

Department of Radiology,, University of Washington,, Seattle, WA, USA.

Background: Pediatric optic pathway gliomas are typically indolent but have a variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced MRI examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast agents. Read More

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http://dx.doi.org/10.1007/s00247-018-4154-4DOI Listing
September 2018
7 Reads

Serial MRIs provide novel insight into natural history of optic pathway gliomas in patients with neurofibromatosis 1.

Orphanet J Rare Dis 2018 04 23;13(1):62. Epub 2018 Apr 23.

Department of Medical Genetics, BC Children's Hospital, University of British Columbia, 4480 Oak Street, Vancouver, Canada.

Background: Optic pathway gliomas (OPGs) are present in 20% of children with neurofibromatosis 1 (NF1) but are less frequently observed in adults. Our goal was to determine the natural history of OPGs in children and adults with NF1.

Results: We analyzed the features of OPGs and other intracranial lesions on 1775 head MRI scans of 562 unselected adults and children with NF1 collected between 2003 and 2015. Read More

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http://dx.doi.org/10.1186/s13023-018-0811-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913802PMC
April 2018
9 Reads

2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.

Am J Med Genet A 2018 05;176(5):1258-1269

Hereditary Cancer Group, The Institute for Health Science Research Germans Trias i Pujol (IGTP)-PMPPC, Barcelona, Spain.

Organized and hosted by the Children's Tumor Foundation (CTF), the Neurofibromatosis (NF) conference is the premier annual gathering for clinicians and researchers interested in neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN). The 2016 edition constituted a blend of clinical and basic aspects of NF research that helped in clarifying different advances in the field. The incorporation of next generation sequencing is changing the way genetic diagnostics is performed for NF and related disorders, providing solutions to problems like genetic heterogeneity, overlapping clinical manifestations, or the presence of mosaicism. Read More

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http://dx.doi.org/10.1002/ajmg.a.38675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918269PMC
May 2018
22 Reads

Endoscopic Transsphenoidal Surgery for an Adult Patient With Giant Exophytic Chiasmatic/Hypothalamic Glioma.

J Craniofac Surg 2018 Jul;29(5):e499-e502

Department of Neurosurgery, Zhucheng People's Hospital, Zhucheng City, China.

Optic pathway hypothalamic gliomas are intrinsic low-grade gliomas involving the optic nerve, chiasm, optic tract, and hypothalamus. The rarity of these tumors and their unpredictable course make assessment and standardization of treatment modalities difficult. Tumor debulking via various transcranial approaches was considered to be effective at controlling tumor growth, but with high rates of severe surgery-related complications. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004543DOI Listing
July 2018
7 Reads

Multicentric Glioblastoma Multiforme Mimicking Optic Neuritis.

Neuroophthalmology 2018 Apr 2;42(2):112-116. Epub 2017 Aug 2.

Department of Radiology, Vittorio Veneto Hospital, Vittorio Veneto, Italy.

A 49-year-old previously healthy woman presented with acute painless visual loss in the right eye, a right relative afferent pupillary defect, and a normal fundus examination. She was diagnosed with retrobulbar "optic neuritis" and given a course of intravenous steroids. Despite treatment, however, she continued to lose vision and serial visual field testing confirmed a junctional scotoma in the fellow eye. Read More

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http://dx.doi.org/10.1080/01658107.2017.1350194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858864PMC
April 2018
23 Reads

Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity.

Neuroimage Clin 2018 11;17:541-548. Epub 2017 Oct 11.

Developmental Imaging & Biophysics Section, University College London Great Ormond Street Institute of Child Health, London, UK.

Background: Radiological biomarkers which correlate with visual function are needed to improve the clinical management of optic pathway glioma (OPG) patients. Currently, these are not available using conventional magnetic resonance imaging (MRI) sequences. The aim of this study was to determine whether diffusion MRI could be used to delineate the entire optic pathway in OPG patients, and provide imaging biomarkers within this pathway which correlate with a patient's visual acuity (VA). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582173025
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http://dx.doi.org/10.1016/j.nicl.2017.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842647PMC
February 2019
16 Reads

Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis: Retrospective Characterization and Analysis of Outcomes.

J Child Neurol 2018 05 5;33(6):375-382. Epub 2018 Mar 5.

1 Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

Isolated optic nerve glioma is a rare tumor with no consensus for the best therapeutic approach. Therefore, tumor control and preservation of visual function remain a challenge. In this retrospective study, we describe our experience over 30 years in a single-institutional cohort of children with isolated optic nerve glioma, focusing on treatments and visual outcomes. Read More

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http://dx.doi.org/10.1177/0883073818758737DOI Listing
May 2018
34 Reads

Moya-Moya syndrome after cranial radiation for optic glioma with NF1. Case report and literature review of syndromic cases.

Neurochirurgie 2018 Mar 21;64(1):63-67. Epub 2018 Feb 21.

Service de neurochirurgie, CHRU de Besançon, université Bourgogne-Franche-Comté, 3, boulevard Alexandre-Fleming, 25030 Besançon, France.

Introduction: Moya-Moya angiopathy is a neurovascular disease that predisposes to ischemic or hemorrhagic strokes. It is generated by a steno-occlusion of the terminal portion of the internal carotid arteries, which induces the development of abnormal neovessels in the deep regions of the brain. Some pathologies such as sickle cell disease, Down syndrome or Graves' disease may be associated with Moya-Moya angiopathy. Read More

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http://dx.doi.org/10.1016/j.neuchi.2017.11.004DOI Listing
March 2018
2 Reads

Awake Surgery for Gliomas within the Right Inferior Parietal Lobule: New Insights into the Functional Connectivity Gained from Stimulation Mapping and Surgical Implications.

World Neurosurg 2018 Apr 31;112:e393-e406. Epub 2018 Jan 31.

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France; Institute for Neuroscience of Montpellier, INSERM 1051, Team "Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors", Saint Eloi Hospital, Montpellier University Medical Center, Montpellier, France; University of Montpellier, Montpellier, France. Electronic address:

Objective: Little is known about the functional role of the white matter connections running within and around the right inferior parietal lobule (IPL). We used direct electrostimulation during awake surgery to investigate this connectivity and to avoid permanent deficit after resection for right IPL gliomas.

Methods: We reviewed patients who underwent awake mapping for a glioma involving the right IPL. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.01.053DOI Listing
April 2018
1 Read

Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1.

J Neurol Surg A Cent Eur Neurosurg 2018 May 2;79(3):268-272. Epub 2018 Jan 2.

Department of Neurosurgery, UMHAT "St. Ivan Rilski", Medical University, Sofia, Bulgaria.

Optic nerve glioma (ONG) is associated in 10% of patients with neurofibromatosis (NF) type 1. To date no consensus has been reached regarding the therapeutic approach and prevention of visual impairment in these patients. Reports in the literature vary from a conservative approach (observation) to the use of single treatment modalities or multimodality protocols of surgical removal, radiotherapy, and/or chemotherapy. Read More

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http://dx.doi.org/10.1055/s-0037-1608869DOI Listing
May 2018
17 Reads

Analysis of Survival Prognosis for Children with Symptomatic Optic Pathway Gliomas Who Received Surgery.

World Neurosurg 2018 Jan 3;109:e1-e15. Epub 2017 Oct 3.

Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Center for Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory for Brain Tumor, Beijing, People's Republic of China. Electronic address:

Objective: The feasibility and prognosis of surgical treatment for children with optic pathway gliomas (OPGs) is controversial. Therefore this study attempted to evaluate the effects of surgery and discuss prognostic factors related to the survival of children with symptomatic OPGs.

Materials And Methods: One-hundred twenty-five children diagnosed with OPGs underwent surgery in the Department of Neurosurgery, Beijing Tiantan Hospital from 2003-2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750173166
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http://dx.doi.org/10.1016/j.wneu.2017.09.144DOI Listing
January 2018
20 Reads

Isolated optic nerve gliomas: a multicenter historical cohort study.

J Neurosurg Pediatr 2017 Dec 6;20(6):549-555. Epub 2017 Oct 6.

1The Gilbert Israeli Neurofibromatosis Center, Dana Children's Hospital.

OBJECTIVE Isolated optic nerve gliomas (IONGs) constitute a rare subgroup of optic pathway gliomas (OPGs). Due to the rarity of this condition and the difficulty in differentiating IONGs from other types of OPGs in most clinical series, little is known about these tumors. Currently, due to lack of evidence, they are managed the same as any other OPG. Read More

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http://dx.doi.org/10.3171/2017.6.PEDS17107DOI Listing
December 2017
12 Reads

Optic Pathway Gliomas Secondary to Neurofibromatosis Type 1.

Semin Pediatr Neurol 2017 05 10;24(2):92-99. Epub 2017 Apr 10.

Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Children with neurofibromatosis type 1 frequently manifest optic pathway gliomas-low-grade gliomas intrinsic to the visual pathway. This review describes the molecular and genetic mechanisms driving optic pathway gliomas as well as the clinical symptoms of this relatively common genetic condition. Recommendations for clinical management and descriptions of the newest imaging techniques are discussed. Read More

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http://dx.doi.org/10.1016/j.spen.2017.04.006DOI Listing
May 2017
5 Reads

Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.

J Neuroophthalmol 2017 09;37 Suppl 1:S23-S32

Cancer and Blood Diseases Institute (PMKdB), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics (PMKdB), University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Oncology (MJF), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics (MJF), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Neuro-Ophthalmology Service (GTL, RAA), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurology and Ophthalmology (GTL, RAA), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Neurofibromatosis Center and Department of Neurology (DHG), Washington University, St. Louis, Missouri; Department of Pediatrics (RL), Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Neurofibromatosis Centre, Department of Neurology (REF), Guy's and St. Thomas' NHS Foundation Trust; and Department of Clinical Neuroscience (REF), King's College, London, United Kingdom.

Optic pathway gliomas (OPGs) occur in 15%-20% of children with neurofibromatosis type 1 (NF1), leading to visual deficits in fewer than half of these individuals. The goal of chemotherapy is to preserve vision, but vision loss in NF1-associated OPG can be unpredictable. Determining which child would benefit from chemotherapy and, equally important, which child is better observed without treatment can be difficult. Read More

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http://Insights.ovid.com/crossref?an=00041327-201709001-0000
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http://dx.doi.org/10.1097/WNO.0000000000000550DOI Listing
September 2017
35 Reads

Morning glory disc anomaly with an ipsilateral enlargement of the optic nerve pathway.

Eur J Paediatr Neurol 2017 Sep 19;21(5):787-791. Epub 2017 May 19.

University Hospitals of Leuven, Belgium.

Purpose: To report three patients with an unilateral morning glory disc anomaly in association with an ipsilateral mild thickening of the optic nerve.

Methods: Three children with a morning glory disc anomaly underwent a magnetic resonance imaging (MRI) of the brain. Ophthalmological, genetic and MRI findings at follow-up are reported. Read More

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http://dx.doi.org/10.1016/j.ejpn.2017.04.1334DOI Listing
September 2017
13 Reads

Growth hormone excess in children with neurofibromatosis type-1 and optic glioma.

Am J Med Genet A 2017 Sep 20;173(9):2353-2358. Epub 2017 Jun 20.

Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.

In children with neurofibromatosis type 1 (NF1) and optic pathways glioma (OPG), growth hormone (GH) excess has been rarely reported and mainly associated to central precocious puberty. The aim of our study is to evaluate the prevalence of GH excess, the association with central precocious puberty, the relation with tumor site and the evolution over time in a large cohort of children with NF1 and OPG. Sixty-four NF1 children with OPG were evaluated. Read More

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http://dx.doi.org/10.1002/ajmg.a.38308DOI Listing
September 2017
37 Reads

Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 1.

Clin Cancer Res 2017 Jun;23(12):e46-e53

Division of Haematology/Oncology, University of Toronto, Toronto, Ontario, Canada.

Although the neurofibromatoses consist of at least three autosomal dominantly inherited disorders, neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis, NF1 represents a multisystem pleiotropic condition very different from the other two. NF1 is a genetic syndrome first manifesting in childhood; affecting multiple organs, childhood development, and neurocognitive status; and presenting the clinician with often complex management decisions that require a multidisciplinary approach. Molecular genetic testing (see article for detailed discussion) is recommended to confirm NF1, particularly in children fulfilling only pigmentary features of the diagnostic criteria. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-0589DOI Listing
June 2017
37 Reads

Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas.

Am J Pathol 2017 Aug 9;187(8):1867-1878. Epub 2017 Jun 9.

Division of Neuropathology, Department of Pathology, New York University Langone Medical Center and Medical School, New York, New York; Department of Neurosurgery, New York University Langone Medical Center and Medical School, New York, New York; Microvascular and Molecular Neurooncology Laboratory, Department of Pathology, New York University Langone Medical Center, New York, New York. Electronic address:

Optic gliomas are brain tumors characterized by slow growth, progressive loss of vision, and limited therapeutic options. Optic gliomas contain various amounts of myxoid matrix, which can represent most of the tumor mass. We sought to investigate biological function and protein structure of the myxoid matrix in optic gliomas to identify novel therapeutic targets. Read More

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http://dx.doi.org/10.1016/j.ajpath.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530906PMC
August 2017
36 Reads

Validation of an automated tractography method for the optic radiations as a biomarker of visual acuity in neurofibromatosis-associated optic pathway glioma.

Exp Neurol 2018 01 3;299(Pt B):308-316. Epub 2017 Jun 3.

Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Introduction: Fractional anisotropy (FA) of the optic radiations has been associated with vision deficit in multiple intrinsic brain pathologies including NF1 associated optic pathway glioma, but hand-drawn regions of interest used in previous tractography methods limit consistency of this potential biomarker. We created an automated method to identify white matter tracts in the optic radiations and compared this method to previously reported hand-drawn tractography.

Method: Automated tractography of the optic radiation using probabilistic streamline fiber tracking between the lateral geniculate nucleus of the thalamus and the occipital cortex was compared to the hand-drawn method between regions of interest posterior to Meyer's loop and anterior to tract branching near the calcarine cortex. Read More

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http://dx.doi.org/10.1016/j.expneurol.2017.06.004DOI Listing
January 2018
10 Reads

Natural history of optic pathway gliomas in a cohort of unselected patients affected by Neurofibromatosis 1.

J Neurooncol 2017 Sep 2;134(2):279-287. Epub 2017 Jun 2.

Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Via Giustiniani 3, 35128, Padova, Italy.

Optic pathway glioma (OPG) represents the most common central nervous system tumor in children with Neurofibromatosis type-1 (NF1). Although overall survival is usually good, no clear prognostic factors have been identified so far. We assessed the natural history of OPG in a cohort of unselected patients affected by NF1. Read More

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http://dx.doi.org/10.1007/s11060-017-2517-6DOI Listing
September 2017
32 Reads

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Oncotarget 2017 Jul;8(29):47206-47215

Department of Neurology and Washington University School of Medicine, St. Louis MO, USA.

Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs). Since many OPGs occur in the context of the Neurofibromatosis Type 1 (NF1) cancer predisposition syndrome, we have previously employed Nf1 genetically-engineered mouse (GEM) strains to study the pathogenesis of these low-grade glial neoplasms. In the light of the finding that human and mouse low-grade gliomas are composed of Olig2+ cells and that Olig2+ oligodendrocyte precursor cells (OPCs) give rise to murine high-grade gliomas, we sought to determine whether Olig2+ OPCs could be tumor-initiating cells for Nf1 optic glioma. Read More

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http://dx.doi.org/10.18632/oncotarget.17589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564557PMC
July 2017
31 Reads

Prognostic Role of Conventional and Dynamic Contrast-Enhanced MRI in Optic Pathway Gliomas.

J Neuroimaging 2017 11 19;27(6):594-601. Epub 2017 May 19.

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Background And Purpose: The natural history of optic pathway glioma (OPG) is highly variable and unpredictable. We present a pilot study of the prognostic role of conventional and dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in the evaluation of OPG.

Methods: We retrospectively reviewed 17 patients with 20 pretreatment OPG lesions who underwent conventional and DCE MRI between January 2010 and December 2016. Read More

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http://dx.doi.org/10.1111/jon.12450DOI Listing
November 2017
17 Reads

Operative simulation of anterior clinoidectomy using a rapid prototyping model molded by a three-dimensional printer.

Acta Neurochir (Wien) 2017 Sep 15;159(9):1619-1626. Epub 2017 May 15.

Department of Neurosurgery (Omori), Toho University Graduate School of Medicine, 6-11-1, Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.

Background: As the anatomical three-dimensional (3D) positional relationship around the anterior clinoid process (ACP) is complex, experience of many surgeries is necessary to understand anterior clinoidectomy (AC). We prepared a 3D synthetic image from computed tomographic angiography (CTA) and magnetic resonance imaging (MRI) data and a rapid prototyping (RP) model from the imaging data using a 3D printer. The objective of this study was to evaluate anatomical reproduction of the 3D synthetic image and intraosseous region after AC in the RP model. Read More

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http://dx.doi.org/10.1007/s00701-017-3202-4DOI Listing
September 2017
5 Reads

Magnetic resonance imaging findings in children with spasmus nutans.

J AAPOS 2017 Apr 8;21(2):127-130. Epub 2017 Mar 8.

Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Background: Spasmus nutans (SN) is a rare pediatric ophthalmologic syndrome characterized by nystagmus, head bobbing, and abnormal head positioning. Historically, SN has been associated with underlying optic pathway gliomas (OPG); however, evidence of this association is based primarily on a small number of isolated case reports. Prior retrospective analyses have found the rate of OPG to be <2%, but these studies only intermittently used neuroimaging with computed tomography, which has limited sensitivity for detection of small lesions in the optic pathway. Read More

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http://dx.doi.org/10.1016/j.jaapos.2017.03.001DOI Listing
April 2017
5 Reads

Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review.

BMC Ophthalmol 2017 Mar 11;17(1):21. Epub 2017 Mar 11.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Kaohsiung, Taiwan.

Background: Malignant optic gliomas are rare, but they rapidly become lethal visual pathway tumors. We present the clinical course, treatment, and prognosis of a case of unilateral malignant optic glioma in a young man with a history of brain glioblastoma multiforme (GBM).

Case Presentation: A 21-year-old man, who had GBM 7 years ago complained of a transient shadow in his vision and presented with normal visual acuity but optic disc edema and an enlarged blind spot in the right eye (oculus dexter, OD). Read More

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http://dx.doi.org/10.1186/s12886-017-0415-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346192PMC
March 2017
10 Reads

Revascularization in a 17-Year-Old Girl with Neurofibromatosis and Severe Hypertension Caused by Renal Artery Stenosis.

Tex Heart Inst J 2017 Feb 1;44(1):50-54. Epub 2017 Feb 1.

Renal artery stenosis caused by neurofibromatosis is a rare cause of renovascular hypertension. This hypertension can develop during childhood and is one of the leading causes of poor outcome. We report the case of a 17-year-old girl who was incidentally diagnosed with severe hypertension. Read More

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http://dx.doi.org/10.14503/THIJ-15-5466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317360PMC
February 2017
15 Reads

Optic pathway glioma of childhood.

Curr Opin Ophthalmol 2017 May;28(3):289-295

Harkness Eye Institute, Columbia University, New York, New York, USA.

Purpose Of Review: Optic pathway gliomas (OPG) are the most common tumor of the anterior visual pathway and can involve the optic nerve, chiasm, tract, and optic radiations. They are typically benign lesions, often pilocytic astrocytomas, which are diagnosed in childhood. We review the epidemiology, clinical presentation, diagnosis, and management of these lesions in patients with and without neurofibromatosis type 1 (NF-1). Read More

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http://Insights.ovid.com/crossref?an=00055735-201705000-0001
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http://dx.doi.org/10.1097/ICU.0000000000000370DOI Listing
May 2017
10 Reads

Primary Orbital Cystic Pilocytic Astrocytoma.

Ocul Oncol Pathol 2016 Oct 20;2(4):280-284. Epub 2016 Jul 20.

Chittagong Eye Infirmary and Training Complex, Chittagong, Bangladesh.

Purpose: To describe the clinical, radiological and histopathological features of a highly unusual primary orbital glioma.

Procedures: A 6-year-old female presented with right-sided proptosis that revealed a well-defined intraconal mass on CT imaging with intact orbital bony walls. During the removal of the lesion, it dissected away freely from the muscles and was separated from the optic nerve and globe. Read More

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http://dx.doi.org/10.1159/000448006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091200PMC
October 2016
23 Reads

Optic nerve glioma with complete intraocular extension.

J Curr Ophthalmol 2016 Dec 3;28(4):228-231. Epub 2016 Aug 3.

Pathology Department, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To present a rare presentation of optic nerve glioma (ONG) with total intraocular extension.

Methods: A 44-year-old man with a history of loss of vision since childhood and recent development of progressive disfiguring proptosis was referred.

Results: The vision in the affected eye was no light perception, and a proptosis of about 2-3 mm was present. Read More

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http://dx.doi.org/10.1016/j.joco.2016.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093854PMC
December 2016
14 Reads
1 Citation

Predicting which NF1 optic pathway gliomas will require treatment.

Neurology 2016 12 4;87(23):2389-2390. Epub 2016 Nov 4.

From the Division of Academic General Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, IL.

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http://dx.doi.org/10.1212/WNL.0000000000003413DOI Listing
December 2016
3 Reads

Optic pathway glioma volume predicts retinal axon degeneration in neurofibromatosis type 1.

Neurology 2016 Dec 4;87(23):2403-2407. Epub 2016 Nov 4.

From the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., C.T.-H., R.J.P.), Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University School of Medicine and Health Sciences (R.I., M.G.L.), Washington, DC; UPMC Eye Center, Eye and Ear Institute (H.I.), Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine; and Department of Bioengineering (H.I.), Swanson School of Engineering, University of Pittsburgh, PA.

Objective: To determine whether tumor size is associated with retinal nerve fiber layer (RNFL) thickness, a measure of axonal degeneration and an established biomarker of visual impairment in children with optic pathway gliomas (OPGs) secondary to neurofibromatosis type 1 (NF1).

Methods: Children with NF1-OPGs involving the optic nerve (extension into the chiasm and tracts permitted) who underwent both volumetric MRI analysis and optical coherence tomography (OCT) within 2 weeks of each other were included. Volumetric measurement of the entire anterior visual pathway (AVP; optic nerve, chiasm, and tract) was performed using high-resolution T1-weighted MRI. Read More

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http://www.neurology.org/content/early/2016/11/04/WNL.000000
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http://dx.doi.org/10.1212/WNL.0000000000003402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177678PMC
December 2016
16 Reads

Primary Gliosarcoma of the Optic Nerve: A Unique Adult Optic Pathway Glioma.

Ophthalmic Plast Reconstr Surg 2017 Jul/Aug;33(4):e88-e92

*Department of Pathology, Division of Neuropathology, and †Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, U.S.A.

A 90-year-old woman presented with 1-year history of right-sided progressive proptosis, neovascular glaucoma, blindness, and worsening ocular pain. No funduscopic examination was possible because of a corneal opacity. Head CT scan without contrast demonstrated a heterogeneous 4. Read More

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http://dx.doi.org/10.1097/IOP.0000000000000798DOI Listing
September 2017
5 Reads

3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.

J Proteomics 2016 10 13;149:77-84. Epub 2016 Feb 13.

Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address:

Neurofibromatosis type 1 (NF1) is a common neurogenetic disorder, in which affected individuals develop tumors of the nervous system. Children with NF1 are particularly prone to brain tumors (gliomas) involving the optic pathway that can result in impaired vision. Since tumor formation and expansion requires a cooperative tumor microenvironment, it is important to identify the cellular and acellular components associated with glioma development and growth. Read More

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http://dx.doi.org/10.1016/j.jprot.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983271PMC
October 2016
28 Reads

High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report.

Am J Case Rep 2016 Oct 24;17:774-781. Epub 2016 Oct 24.

Department of Research, Inc., Riordan-McKenna Institute, Panama City, Panama.

BACKGROUND In neurofibromatosis type 1 (NF1) disease, the loss of the tumor suppressor function of the neurofibromin gene leads to proliferation of neural tumors. In children, the most frequently identified tumor is the optic pathway glioma. CASE REPORT We describe the case of a 5-year-old child who was diagnosed with NF1 and optic pathway tumor onset at the age of 14 months. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081233PMC
October 2016
18 Reads

Optic Gliomas in Neurofibromatosis Type 1.

J Pediatr Ophthalmol Strabismus 2016 Nov 18;53(6):334-338. Epub 2016 Aug 18.

Purpose: To examine the incidence, presentation, and outcome of optic gliomas in children with neurofibromatosis type 1 (NF1) in Southern California Kaiser Permanente.

Methods: The authors queried the Southern California Kaiser Permanente electronic medical record database to find patients diagnosed as having NF1. Genetics, ophthalmology, and imaging medical records of patients with optic glioma were reviewed. Read More

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http://dx.doi.org/10.3928/01913913-20160810-03DOI Listing
November 2016
18 Reads

Optic Pathway Glioma and Cerebral Focal Abnormal Signal Intensity in Patients with Neurofibromatosis Type 1: Characteristics, Treatment Choices and Follow-up in 134 Affected Individuals and a Brief Review of the Literature.

Anticancer Res 2016 Aug;36(8):4095-121

Department of Oral and Cranio-Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Unlabelled: Optic pathway glioma (OPG) is a rare neoplasm and a defining feature of neurofibromatosis type 1 (NF1), a tumor suppressor genetic disorder. OPG predominantly arises during childhood. In contrast to sporadic OPG, this neoplasm frequently appears to show a more favorable course. Read More

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August 2016
20 Reads

Imaging of orbital disorders.

Handb Clin Neurol 2016 ;135:659-672

Department of Radiology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Diseases of the orbit can be categorized in many ways, but in this chapter we shall group them according to etiology. Inflammatory diseases of the orbits may be infectious or noninfectious. Of the infections, orbital cellulitis is the most common and typically arises as a complication of acute sinusitis. Read More

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http://dx.doi.org/10.1016/B978-0-444-53485-9.00031-3DOI Listing
February 2017
15 Reads

Pediatric Optical Coherence Tomography in Clinical Practice-Recent Progress.

Invest Ophthalmol Vis Sci 2016 07;57(9):OCT69-79

University of Leicester Ulverscroft Eye Unit, Leicester, United Kingdom.

Purpose: Optical coherence tomography (OCT) has revolutionized the diagnosis and management of adult retinal and optic nerve disease. Children were deprived of this technology until the recent development of handheld spectral-domain OCT (HH-SDOCT). In this article, we review the applications of OCT imaging in pediatric ophthalmology. Read More

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http://dx.doi.org/10.1167/iovs.15-18825DOI Listing
July 2016
6 Reads

Distinguishing optic pathway glioma and retinitis pigmentosa with visual field testing.

Can J Ophthalmol 2016 Jun 16;51(3):e94-6. Epub 2016 Apr 16.

University of Iowa, Iowa City, Iowa; Howard Hughes Medical Institute, Iowa City, Iowa. Electronic address:

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http://dx.doi.org/10.1016/j.jcjo.2016.01.009DOI Listing
June 2016
5 Reads

Prechiasmatic transection of the optic nerve in optic nerve glioma: technical description and surgical outcome.

Neurosurg Rev 2017 Jan 26;40(1):135-141. Epub 2016 May 26.

Department of Neurosurgery, Clemens Hospital, Academic Hospital of Münster University, Düesbergweg 124, 48153, Münster, Germany.

Optic pathway glioma (OPG) encompasses a spectrum of findings ranging from lesions confined to the optic nerve only, lesions affecting the optic chiasm and hypothalamus, and lesions with diffuse involvement of a large part of the optic pathway and neighboring structures. The majority of pediatric low-grade astrocytomas in the optic/chiasmatic region are typical pilocytic astrocytoma. The rest of them (10 %) may be other gliomas such as fibrillary pilomyxoid astrocytoma (grade 2 WHO). Read More

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http://dx.doi.org/10.1007/s10143-016-0747-2DOI Listing
January 2017
9 Reads