725 results match your criteria Optic Nerve Glioma Imaging

Neurological manifestations of neurofibromatosis type 1: our experience.

Neurologia (Engl Ed) 2022 Jun 26;37(5):325-333. Epub 2021 May 26.

Departamento de Pediatría, Radiología y Medicina Física, Facultad de Medicina de Zaragoza, Universidad de Zaragoza, Zaragoza, Spain.

Introduction: Neurofibromatosis type 1 (NF1) is a progressive multisystem disorder following an autosomal dominant inheritance pattern that presents with multiple neurological manifestations.

Methods: We reviewed medical histories of patients with NF1 followed up at our hospital's paediatric neurology department from May 1990 to 31 December 2018. We collected data on neurological symptoms. Read More

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A rare MRI finding of NF-1: perineural arachnoidal gliomatosis.

Childs Nerv Syst 2022 Jun 2. Epub 2022 Jun 2.

Division of Pediatric Radiology, Department of Radiology, Gazi University School of Medicine, 06560, Ankara, Turkey.

Optic pathway gliomas are the most common central nervous system neoplasms in patients with neurofibromatosis type 1. Perineural arachnoidal gliomatosis is a rare and distinctive growth pattern of optic nerve glioma, in which the tumor infiltrates through the pia mater and pre-dominantly involves the subarachnoid space around the optic nerve. Here, we report an 8-year-old girl with perineural arachnoidal gliomatosis associated with neurofibromatosis type 1. Read More

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Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions.

J Pediatr Ophthalmol Strabismus 2022 Apr 21:1-15. Epub 2022 Apr 21.

Purpose: To report wide-field fundus imaging and fluorescein angiography findings in conditions mimicking retinoblastoma (pseudoretinoblastoma).

Methods: The clinical and imaging records of 28 patients (36 eyes) imaged with RetCam 3 (Clarity Medical Systems, Inc) wide-field fundus photography and fluorescein angiography who were diagnosed as having various pseudoretinoblastoma disorders between February 2020 and August 2021 were retrospectively evaluated.

Results: Most patients were referred with suspicion of retinoblastoma. Read More

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Lessons learnt from two interesting cases of malignant optic nerve glioma.

J Neuroradiol 2022 Mar 9. Epub 2022 Mar 9.

Department of Neurosurgery, National Neuroscience Institute, 11 Jln Tan Tock Seng, Singapore 308433, Singapore; Department of Neuroradiology, National Neuroscience Institute, 11 Jln Tan Tock Seng, Singapore 308433, Singapore.

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Evaluation of optic nerve diameters in individuals with neurofibromatosis and comparison of normative values in different pediatric age groups.

Clin Imaging 2022 May 28;85:83-88. Epub 2022 Feb 28.

Department of Radiology, Medical Faculty, Kocaeli University, Kocaeli, Turkey. Electronic address:

Aim: Our study aimed to report the normative values for optic nerve diameter in different age groups in MR imaging (MRI) in the pediatric population and to find a cut-off value for diagnosis in different age groups to be used for the diagnosis of optic glioma in patients with Neurofibromatosis 1(NF1).

Materials-methods: Orbital MRI obtained from 2011 to 2021 for children with and without NF1 were reviewed. Patients were divided into three groups: NF1 with glioma (group 1, n = 38), NF1 without glioma (group 2, n = 57), and healthy controls (group 3, n = 295). Read More

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Imaging Findings of Pediatric Orbital Masses and Tumor Mimics.

Radiographics 2022 May-Jun;42(3):880-897. Epub 2022 Mar 4.

From the Departments of Radiology (A.K.J., J.B.G., L.J.E., G.B.L., J.C.B., W.B., V.M.S.), Ophthalmology (L.A.D.), Neurology (G.F.K.), Neurosurgery (W.B.), and Radiation Oncology (N.N.L.), Mayo Clinic, 200 1st St SW, Rochester, MN 55905.

Pediatric orbital masses are not common but encompass a wide spectrum of benign and malignant entities that range from developmental anomalies to primary and secondary orbital malignancies and metastatic disease. Certain orbital tumors are unique to pediatric patients, such as retinoblastoma and neuroblastoma. Clinical symptoms and signs are often insufficient to differentiate between orbital lesions, and imaging is essential for narrowing the diagnostic considerations and determining the most appropriate management strategy. Read More

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The role of imaging features and resection status in the survival outcome of sporadic optic pathway glioma children receiving different adjuvant treatments.

Neurosurg Rev 2022 Jun 1;45(3):2277-2287. Epub 2022 Feb 1.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 119, South 4th Ring Road, Fengtai District, Beijing, 100070, China.

Optic pathway glioma (OPG) is a rare brain tumor affecting children, with no standard treatment strategy. This study described the sporadic OPG survival outcomes after surgical treatment and analyzed the role of imaging features and resection status in children receiving different adjuvant treatments. This retrospective study included 165 OPG patients whose clinical information were obtained from the hospital record system. Read More

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Whole-body MRI evaluation in neurofibromatosis type 1 patients younger than 3 years old and the genetic contribution to disease progression.

Orphanet J Rare Dis 2022 01 29;17(1):24. Epub 2022 Jan 29.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, 88, Olympic-ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.

Background: Neurofibromatosis type 1 (NF1) is a common human genetic disease with age-dependent phenotype progression. The overview of clinical and radiological findings evaluated by whole-body magnetic resonance imaging (WBMRI) in NF1 patients < 3 years old assessed with a genetic contribution to disease progression is presented herein.

Methods: This study included 70 clinically or genetically diagnosed NF1 patients who received WBMRI before 3 years old. Read More

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January 2022

Cranio-Orbital Approach for Single-Stage En Bloc Resection of Optic Nerve Glioma: Technical Note.

Oper Neurosurg (Hagerstown) 2022 02;22(2):e95-e99

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA.

Background And Importance: There is no consensus on the optimal surgical approach for managing optic nerve gliomas. For solely intraorbital tumors, a single-stage lateral orbitotomy approach for resection may be performed, but when the nerve within the optic canal is affected, two-stage cranial and orbital approaches are often used. The authors describe their technique to safely achieve aggressive nerve resection to minimize the probability of recurrence that might affect the optic tracts, optic chiasm, and contralateral optic nerve. Read More

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February 2022

Glioblastoma in the optic chiasm: A case report.

Radiol Case Rep 2022 Mar 28;17(3):729-734. Epub 2021 Dec 28.

Neuroradiologa, Fundación Valle del Lili. Cali, Colombia.

Malignant optic gliomas are an uncommon pathology, with around 67 cases reported worldwide in the literature. We present the case of a 77-year-old-male with a two-month history of progressive vision loss, ultimately leading to bilateral blindness. The initial clinical suspicion was a non-inflammatory ischemic optic neuropathy. Read More

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Tumor load rather than contrast enhancement is associated with the visual function of children and adolescents with optic pathway glioma - a retrospective Magnetic Resonance Imaging study.

J Neurooncol 2022 Feb 7;156(3):589-597. Epub 2022 Jan 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neuroradiology, Augustenburger Platz 1, 13353, Berlin, Germany.

Introduction: Optic pathway gliomas are often asymptomatic tumors occurring in children with neurofibromatosis type 1 (NF1 + OPG) or sporadically (spOPG). Treatment is usually prompted by visual loss and/or tumor progression on MRI. The aim of this study was to investigate the relationship between visual acuity (VA), tumor growth, and contrast enhancement to provide more distinct indications for the administration of gadolinium-based contrast agents. Read More

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February 2022

[Prognostic factors of neurofibromatosis type 1-associated optic pathway gliomas in children].

J Fr Ophtalmol 2022 Feb 28;45(2):173-184. Epub 2021 Dec 28.

Services Ophtalmologie du Pr-Denis, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.

Introduction: Optic pathway glioma (OPG) is a classic complication of neurofibromatosis type 1 (NF1) and can impair visual function in children with this condition. The objective of this study is to describe clinical, paraclinical and prognostic characteristics of OPG associated with NF1.

Materials And Methods: In this retrospective observational study of children followed for OPG associated with NF1 in a University Hospital, we analyzed the ophthalmological examination, brain and orbital imaging, management and the presence of associated endocrinopathy. Read More

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February 2022

Gamma Knife Radiosurgery in the Management of Hypothalamic Glioma: A Case Report with Long-Term Follow-Up.

Pediatr Neurosurg 2022 30;57(2):118-126. Epub 2021 Dec 30.

Department of Neurological Surgery, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Optic pathway/hypothalamic gliomas are rare pediatric brain tumors. The management paradigm for these challenging tumors includes chemotherapy, radiotherapy, or surgical resection, but the optimal management strategy remains elusive. Gamma knife radiosurgery (GKRS) has emerged as a promising treatment for such lesions as documented by a small number of cases in the literature. Read More

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Atypical Giant Suprasellar Prolactinoma Presenting With Visual Field Changes in the Absence of Symptoms of Hyperprolactinemia.

Cureus 2021 Nov 16;13(11):e19632. Epub 2021 Nov 16.

Neurosciences and Pediatrics, University of California San Diego, San Diego, USA.

Prolactinomas are benign tumors that make up the majority of all pituitary adenoma cases and present most commonly in women. Prolactinomas presenting in adolescents and children, however, are extremely rare. We report a case of a 17-year-old male who presented with a six-month history of headaches and a previously unrecognized visual field deficit on examination. Read More

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November 2021

Neuroimaging Features of Optic Nerve Hemangioblastoma Identified by Conventional and Advanced Magnetic Resonance Techniques: A Case Report and Literature Review.

Front Oncol 2021 12;11:763696. Epub 2021 Nov 12.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Optic nerve hemangioblastoma is a very rare benign tumor with only 39 reported cases by now. It appears to be hyperintense on T2-weighted images with a significant enhancement on contrast scans, which are similar to glioma and meningioma. Due to the lack of specificity in MRI manifestations, optic nerve hemangioblastoma is often misdiagnosed. Read More

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November 2021

Optic Nerve Abnormalities in Morning Glory Disc Anomaly: An MRI Study.

J Neuroophthalmol 2022 06 29;42(2):199-202. Epub 2021 Oct 29.

Ophthalmology Department (D-TN, DB-G, MPR), APHP, Necker Enfants Malades University Hospital, Paris, France; Paris Descartes University (D-TN, DB-G, MPR), Sorbonne Paris Cité, France; Necker Enfants Malades University Hospital Pediatric Radiology Department, (NB), APHP, Paris, France; INSERM U1000 (NB), Imagine Institute, Paris Descartes University, Paris, France; CNRS Unit FR33636 (DB-G), Paris Descartes University, Paris, France; and Borelli Center (MPR), UMR 9010, CNRS-SSA-ENS Paris Saclay-Paris University, France.

Background: The morning glory disc anomaly (MGDA) is a rare congenital malformation of the optic disc. The association with a significant enlargement of the optic nerve has been recently reported in a few cases, raising the question of potentially associated optic nerve gliomas. The objective was to report the anatomy of optic nerves on MRI in patients with MGDA. Read More

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Optic pathway glioma and the sex association in neurofibromatosis type 1: a single-center study.

Orphanet J Rare Dis 2021 11 22;16(1):489. Epub 2021 Nov 22.

Center for Rare Diseases, Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Palle Juul-Jensens, Boulevard 99, 8200, Aarhus N, Denmark.

Background: Low-grade optic pathway glioma (OPG) develops in 15-20% of children with neurofibromatosis type 1 (NF1). OPGs are symptomatic in 30-50% and one-third of these require treatment. A few studies have suggested female sex as a risk factor for visual impairment associated with NF1-OPG. Read More

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November 2021

Regression and pseudoprogression of pediatric optic pathway glioma in patients treated with proton beam therapy.

Pediatr Blood Cancer 2022 03 12;69(3):e29434. Epub 2021 Nov 12.

Proton Therapy Center, National Cancer Center, Goyang-si, Republic of Korea.

Purpose: We examined regression patterns in pediatric optic pathway gliomas (OPGs) after proton beam therapy (PBT) and evaluated local control and visual outcomes.

Methods: A total of 42 brain magnetic resonance imaging (MRI) scans from seven consecutive sporadic OPGs that were initially treated with chemotherapy and received PBT between June 2007 and September 2016 at the National Cancer Center, Korea were analyzed. Patients underwent brain MRI regularly before and after PBT. Read More

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Non-inferiority of a non-gadolinium-enhanced magnetic resonance imaging follow-up protocol for isolated optic pathway gliomas.

Pediatr Radiol 2022 Mar 9;52(3):539-548. Epub 2021 Nov 9.

Department of Radiology, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.

Background: Pediatric patients with optic pathway gliomas (OPGs) typically undergo a large number of follow-up MRI brain exams with gadolinium-based contrast media (GBCM), which have been associated with gadolinium tissue retention. Therefore, careful consideration of GBCM use in these children is warranted.

Objective: To investigate whether GBCM is necessary for OPG MR imaging response assessment using a blinded, non-inferiority, multi-reader study. Read More

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Awake Microsurgical Resection for Optochiasmatic Cavernous Malformation.

World Neurosurg 2022 01 21;157:159. Epub 2021 Oct 21.

Department of Neurosurgery, Universidade Federal de Sao Paulo, São Paulo-SP, Brazil; Hospital Beneficência Portuguesa de São Paulo, São Paulo-SP, Brazil. Electronic address:

Cavernous malformations (CM) affect approximately 0.5% of the population, with only a limited portion being located in the optic nerve and chiasma. The clinical presentation is determined by their locations. Read More

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January 2022

"Pulsating proptosis and heavy eye syndrome precipitated by neurofibromatosis type 1: A case report".

Medicine (Baltimore) 2021 Oct;100(42):e27575

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Rationale: Neurofibromatosis type 1 (NF1) is a hereditary disease characterized by café-au-lait spots, peripheral neurofibromas, Lisch nodules, optic nerve glioma, and sphenoid wing dysplasia. Pulsating proptosis is associated with a sphenoid bony defect. Heavy eye syndrome is characterized by acquired esohypotropia in patients with high myopia. Read More

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October 2021

Optic Nerve Germinoma and Transient Spontaneous Regression-More Than Meets the Eye.

J Pediatr Hematol Oncol 2022 Jul 15;44(5):255-260. Epub 2021 Oct 15.

Departments of Paediatric Haematology/Oncology.

Infiltration of the optic pathway by germ cell tumors is exceptional and can lead to confusion with glioma or inflammatory conditions. We present the case of a 14-year-old girl with an optic nerve germinoma extending to the hypothalamus and manifesting as panhypopituitarism and visual loss. The patient experienced spontaneous regression of the lesion followed by secondary deterioration requiring treatment. Read More

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A Unique Case of Sporadic Optic Pathway Glioma in an Infant With Acute Nystagmus.

Cureus 2021 Aug 30;13(8):e17568. Epub 2021 Aug 30.

Radiology, University of South Alabama, Mobile, USA.

Optic pathway gliomas (OPGs) are a classic pathology seen in patients with neurofibromatosis I (NF-1); however, they are frequently seen as sporadic masses in patients with mutations activating the mitogen-activated protein kinase (MAPK) pathway. These sporadic tumors present rapidly with vision deficits, compared to those in neurofibromatosis I, which may be found incidentally. They can involve multiple aspects of the optic pathway and have classic imaging findings that make definitive diagnosis possible with magnetic resonance imaging. Read More

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A diagnostic tree for differentiation of adult pilocytic astrocytomas from high-grade gliomas.

Eur J Radiol 2021 Oct 8;143:109946. Epub 2021 Sep 8.

Department of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To develop a diagnostic tree analysis (DTA) model based on demographical information and conventional MRI for differential diagnosis of adult pilocytic astrocytomas (PAs) and high-grade gliomas (HGGs; World Health Organization grade III-IV).

Methods: A total of 357 adult patients with pathologically confirmed PA (n = 65) and HGGs (n = 292) who underwent conventional MRI were included. The patients were randomly divided into training (n = 250) and validation (n = 107) datasets to assess the diagnostic performance of the DTA model. Read More

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October 2021

[Intraosseous metastasis of K27-mutant glioma].

Arkh Patol 2021 ;83(3):40-44

Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia.

Glioma metastasis outside the central nervous system is a quite rare phenomenon. The disease in a young woman manifested itself as back pain and loss of vision in the left eye. Magnetic resonance imaging (MRI) revealed a tumor of the optic nerve; positron emission tomography showed multiple secondary bone changes. Read More

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Imaging of the Primary Visual Pathway based on Visual Deficits.

J Clin Imaging Sci 2021 7;11:19. Epub 2021 Apr 7.

Department of Radiology, Mayo Clinic, Jacksonville, Florida, United States.

Vision loss can occur due to a variety of etiologies along the primary visual pathway. Understanding the anatomic organization of the visual pathway, which spans the globe to the occipital cortex, can help tailor neuroimaging to identify the cause of visual dysfunction. In this review, relevant anatomy and optimization of computed tomography and magnetic resonance imaging techniques will be described. Read More

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Correlation Between Ophthalmologic and Neuroradiologic Findings in Type 1 Neurofibromatosis.

J Neuroophthalmol 2022 03 23;42(1):101-107. Epub 2021 Mar 23.

Ophthalmology Department (GG, JE-L, CM, OF, EB, AM, FF-R, SP), and Neuroradiology Department (GA), Centro Hospitalar Universitário São João, Porto, Portugal; and Surgery and Physiology Department (FF-R, SP), Faculty of Medicine, University of Porto, Portugal.

Background: Neurofibromatosis Type 1 (NF-1) is a genetic disease affecting the eye, and ocular findings such as Lisch nodules (LN) or optic pathway gliomas (OPGs) are a part of its diagnostic criteria. Recent imaging technologies such as infrared (IR) imaging and optical coherence tomography (OCT) have highlighted the visualization of choroidal focal abnormalities in these patients, even in the absence of other ocular lesions. This study aimed to establish a morphological multimodal evaluation of choroidal findings in patients with NF-1, correlating them with central nervous system (CNS) findings. Read More

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Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I.

Orphanet J Rare Dis 2021 03 23;16(1):147. Epub 2021 Mar 23.

Department of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.

Background: Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity. It is caused by mutation in the NF1 gene on chromosome 17 encoding for neurofibromin, a protein with oncosuppressive activity, and it is 50% sporadic or inherited. The disease is characterized by a broad spectrum of clinical manifestations, mainly involving the nervous system, the eye and skin, and a predisposition to develop multiple benign and malignant neoplasms. Read More

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A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.

Neuro Oncol 2021 10;23(10):1777-1788

Department of Hematology and Oncology Nationwide Children's Hospital, Columbus, Ohio, USA.

Background: Pediatric low-grade gliomas (pLGGs) are the most common childhood brain tumor. Progression-free survival (PFS) is much lower than overall survival, emphasizing the need for alternative treatments. Sporadic (without neurofibromatosis type 1) optic pathway and hypothalamic gliomas (OPHGs) are often multiply recurrent and cause significant visual deficits. Read More

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October 2021

Color-doppler Flow Imaging Might Help Diagnose Optic Nerve Glioma.

Ophthalmology 2021 03;128(3):392

Department of Neuro-Radiology, Foundation Adolphe de Rothschild Hospital, Paris, France.

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