660,412 results match your criteria Optic Nerve Glioma Imaging


A photoelectrochemical sensing strategy based on single-layer MoS modified electrode for methionine detection.

J Pharm Biomed Anal 2018 Nov 28;165:94-100. Epub 2018 Nov 28.

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, State Key Laboratory Base of Eco-Chemical Engineering, Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Provincial Key Laboratory of Rubber Plastics, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

MoS, a typical transition metal disulfide, is widely used in the photoelectrochemical (PEC) sensor construction. In general, MoS based PEC sensor are "signal-on" strategies. Surprisingly, we discovered that the PEC response of MoS was quenched by methionine greatly. Read More

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November 2018
2 Reads

The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis.

J Neurol Sci 2018 Nov 28;396:225-231. Epub 2018 Nov 28.

Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China. Electronic address:

Background And Objective: Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON.

Methods: Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Read More

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November 2018

A simple yet sensitive colorimetric nitrite ions assay based on diazotization with p‑Aminobenzoic and coupling with phloroglucinol in acidic medium.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Aug 25;210:398-404. Epub 2018 Aug 25.

Key Laboratory of Bioelectrochemistry & Analysis of Gansu Province, College of Chemistry& Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China. Electronic address:

Immoderate intake of nitrite (NO) is deleterious human health and may result in causing dangerous diseases. In this study, nitrite detection system was successfully fabricated based on a unique diazo-coupling reaction of p‑Aminobenzoic acid (PABA) and phloroglucinol (1, 3, 5‑trihydroxybenzene). Upon the presence of NO in an acid medium, p‑Aminobenzoic acid could not only form diazonium ion easily but also couple with p‑Aminobenzoic acid, and results forming yellow water-soluble azo dye that shows maximum absorption at 434 nm. Read More

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August 2018
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The Bacterial Metabolite Indole Inhibits Regeneration of the Planarian Flatworm Dugesia japonica.

iScience 2018 Nov 16;10:135-148. Epub 2018 Nov 16.

Allen Discovery Center at Tufts University, Medford, MA 02155, USA. Electronic address:

Planarian flatworms have been used for over a century as models for regeneration. Planarians live in aquatic environments with constant exposure to microbes, but the mechanisms by which bacteria may mediate planarian regeneration are largely unknown. We characterized the microbiome of laboratory populations of the planarian Dugesia japonica and determined how individual bacteria impact D. Read More

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November 2018
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Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018

Visual stimulus-driven functional organization of macaque prefrontal cortex.

Neuroimage 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Sensorimotor Research, National Eye Institute, National Institute of Mental Health, National Institutes of Health, 20892, Bethesda, United States. Electronic address:

The extent to which the major subdivisions of prefrontal cortex (PFC) can be functionally partitioned is unclear. In approaching the question, it is often assumed that the organization is task dependent. Here we use fMRI to show that PFC can respond in a task-independent way, and we leverage these responses to uncover a stimulus-driven functional organization. Read More

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December 2018
2 Reads

Hide and Seek.

Surv Ophthalmol 2018 Dec 3. Epub 2018 Dec 3.

Wills Eye Hospital , Thomas Jefferson University, Philadelphia PA.

A 51-year-old woman with a previous history of rheumatoid arthritis experienced painless and progressive visual loss in the left eye for three weeks. Fundus examination revealed optic disc pallor in her left eye. Magnetic resonance imaging of the brain and orbits showed enhancement of the pachymeninges and hypersignal at the left optic nerve. Read More

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December 2018
1 Read

The X Factor.

Surv Ophthalmol 2018 Dec 3. Epub 2018 Dec 3.

Associate Professor, Departments of Clinical Neurosciences and Surgery, University of Calgary.

A 45-year-old Caucasian woman presented with chronic bilateral, painless, progressive, peripheral vision loss. She was found to have bilateral optic atrophy and non-enhancing multifocal white matter lesions on magnetic resonance imaging of the brain. Cerebrospinal fluid analysis showed elevated myelin basic protein. Read More

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December 2018

Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration.

Neuron 2018 Dec;100(5):1241-1251.e7

Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland; Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

Large numbers of brain regions are active during behaviors. A high-resolution, brain-wide activity map could identify brain regions involved in specific behaviors. We have developed functional ultrasound imaging to record whole-brain activity in behaving mice at a resolution of ∼100 μm. Read More

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December 2018
1 Read

An Unbiased View of Neural Networks: More than Meets the Eye.

Neuron 2018 Dec;100(5):1019-1021

Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA 94305, USA; Neurosciences Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; BioX, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

In this issue of Neuron, Macé et al. (2018) use whole-brain functional ultrasound imaging in mice to unveil the circuits involved reflexive eye movements. They separated the sensory and motor networks and discovered that certain eye movements robustly suppress the amygdala. Read More

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December 2018
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Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011902. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Read More

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December 2018
4 Reads

Binocular Summation for Reflexive Eye Movements: A Potential Diagnostic Tool for Stereodeficiencies.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5816-5822

Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, United States.

Purpose: Stereoscopic vision, by detecting interocular correlations, enhances depth perception. Stereodeficiencies often emerge during the first months of life, and left untreated can lead to severe loss of visual acuity in one eye and/or strabismus. Early treatment results in much better outcomes, yet diagnostic tests for infants are cumbersome and not widely available. Read More

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December 2018

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5773-5784

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels and retinal ganglion cell axons during early eye development. Failure to close the OF is the developmental basis for uveal coloboma, a congenital blinding eye disease that significantly contributes to childhood blindness. Genes specifically expressed in the OF region may play important roles in OF development and function. Read More

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December 2018

Staphylococcus aureus from ocular and otolaryngology infections are frequently resistant to clinically important antibiotics and are associated with lineages of community and hospital origins.

PLoS One 2018 6;13(12):e0208518. Epub 2018 Dec 6.

Infectious Diseases Institute, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America.

Staphylococcus aureus is an important human pathogen that causes serious antibiotic-resistant infections. Its population structure is marked by the appearance and dissemination of successful lineages across different settings. To begin understanding the population structure of S. Read More

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December 2018
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The eyes know it: Toddlers' visual scanning of sad faces is predicted by their theory of mind skills.

PLoS One 2018 6;13(12):e0208524. Epub 2018 Dec 6.

Department of Psychology, Concordia University, Montréal, Québec, Canada.

The current research explored toddlers' gaze fixation during a scene showing a person expressing sadness after a ball is stolen from her. The relation between the duration of gaze fixation on different parts of the person's sad face (e.g. Read More

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December 2018
4 Reads

Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens.

PLoS One 2018 6;13(12):e0207611. Epub 2018 Dec 6.

Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Infectious laryngotracheitis (ILT) is an upper respiratory tract disease of chickens that is caused by infectious laryngotracheitis virus (ILTV), an alphaherpesvirus. This disease causes significant economic loses in poultry industries worldwide. Despite widespread use of commercial live attenuated vaccines, many poultry industries continue to experience outbreaks of disease caused by ILTV. Read More

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December 2018
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Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.

On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More

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December 2018
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[Evaluation of The Medical Board Exam in Portugal].

Acta Med Port 2018 Nov 30;31(11):670-679. Epub 2018 Nov 30.

Faculdade de Medicina. Universidade de Coimbra. Coimbra. Serviço de Otorrinolaringologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Coimbra Institute for Clinical and Biomedical Research (iCBR). Coimbra. Portugal.

Introduction: There is a high heterogeneity in the structure of postgraduate medical training evaluation worldwide. However, in contrast to other countries, there have been no scientific studies of the final medical board examination, in Portugal. The present study aimed to evaluate the adequacy of the medical board examination including its validity as measured by its association with medical school grade average and national seriation examination. Read More

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November 2018

Follow-up and adherence to glaucoma care by newly diagnosed glaucoma patients in enugu, nigeria.

Ophthalmic Epidemiol 2018 Dec 6:1-7. Epub 2018 Dec 6.

a College of Medicine, Enugu State University of Technology(ESUT), Enugu State University of Science and Technology (ESUT) Teaching Hospital Parklane , The Eye Specialists Hospital (TESH) , Enugu , Nigeria.

Purpose: To determine uptake, adherence and influencing factors to follow-up care by newly diagnosed glaucoma patients from free eye screening exercise.

Methods: The study was a cross-sectional survey of newly diagnosed glaucoma patients during free eye screenings carried out in March and October, 2016 in Enugu, Nigeria. Data on participants were analyzed after a minimum of 6 months from the screening for uptake and adherence to follow-up care. Read More

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December 2018
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Techniques for improving ophthalmic studies performed on administrative databases.

Ophthalmic Epidemiol 2018 Dec 6:1-3. Epub 2018 Dec 6.

e Department of Ophthalmology , Scheie Eye Institute, University of Pennsylvania , Philadelphia , Pennsylvania , USA.

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December 2018
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Pretreatment Hearing Level-Another Prognostic Factor in Sudden Sensorineural Hearing Loss-Reply.

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

ENT Institute, Otorhinolaryngology Department, Eye and ENT Hospital of Fudan University, Shanghai, China.

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December 2018
1 Read

New Onset of Blurred Vision and Floaters.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland.

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December 2018

Association Between Noninfectious Uveitis and Psychological Stress.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Uveitis involves dysregulation of the ocular immune system. Stress has been shown to affect immune function, but it is unclear whether there is an association between stress and uveitis.

Objective: To determine whether having uveitis is associated with psychological stress. Read More

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December 2018
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Eye and Vision Health for Tomorrow: From Recommendations to Coordinated Action.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Indiana University School of Optometry, Bloomington.

In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue initiated by this report. In 2018, a stakeholder meeting assessed the feasibility of establishing a backbone organization, a national center that can provide technical and resource assistance regarding eye and vision health. Read More

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December 2018
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A Woman With Fluctuating Left Eye Swelling and Redness.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois.

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December 2018

Bayesian analysis of retinotopic maps.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Psychology, New York University, New York, United States.

Human visual cortex is organized into multiple retinotopic maps. Characterizing the arrangement of these maps on the cortical surface is essential to many visual neuroscience studies. Typically, maps are obtained by voxel-wise analysis of fMRI data. Read More

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December 2018
2 Reads

[Acromegaly].

Ugeskr Laeger 2018 Dec;180(49)

Acromegaly is a rare and disabling disease with a plethora of symptoms and signs attributed to sustained elevations and actions of growth hormone and insulin-like growth factor 1. Acromegaly is characterised by excessive somatic growth and multiple comorbidities in addition to occasional compression of the optic nerve and hypopituitarism due to the underlying adenoma. The course of the disease is insidious, and a diagnostic delay of 5-10 years is typical, and this pre-diagnostic period is also associated with increased morbidity. Read More

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December 2018

Ischemic optic neuropathy in robotic-assisted gynaecologic surgery: A case report.

J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.

Ceyhan State Hospital Ophthalmology Department, Adana, Turkey.

The study was aimed to present a rare case of who developed non arteritic anterior ischemic optic neuropathy (NAION) following robotic-assisted gynaecologic surgery. A 58-year-old female patient presented with vision loss in right eye after non-complicated robotic-assisted total hysterectomy and bilateral salpingo-oopherectomy. We observed on fundoscopy optic disc edema and splinter hemorrhages at the optic disc edges. Read More

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December 2018
2 Reads

Visual detection of cancer cells by using in situ grown functional CuSe/reduced graphene oxide hybrids acting as an efficient nanozyme.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. and College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P. R. China.

A simple protocol for in situ growth of Cu2-xSe nanoparticles on graphene oxide hybrids (Cu2-xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2-xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2-xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. Read More

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December 2018

A gold nanorod-based plasmonic platform for multi-logic operation and detection.

Nanotechnology 2019 Feb;30(5):055503

College of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.

A multi-logic gate platform was designed based on morphological changes of gold nanorods (AuNRs) resulted from the iodine-mediated etching. By utilizing the anti-etching effects of mercapto compounds and Au-Hg amalgams as well as the etch-promoting effect of Cu, we successfully built five logic gates, namely, AND, NOR, XNOR, YES and IMPLY, along with a three-input combinational logic gate XNOR-IMPLY. The platform was versatile and easy to use, did not require complex surface modification or separation/purification steps as the conventional AuNR-based logic gates did. Read More

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February 2019
1 Read

Feasibility of closed-MLC tracking using high sensitivity and multi-layer electronic portal imagers.

Phys Med Biol 2018 Dec 6;63(23):235030. Epub 2018 Dec 6.

Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, United States of America. Author to whom any correspondence should be addressed.

In radiation therapy, improvements in treatment conformality are often limited by movement of target tissue. To better treat the target, tumor tracking strategies involving beam's-eye-view (BEV) have been explored. However, localization surrogates like implanted fiducial markers may sometimes leave the field-of-view (FOV), as defined by the linear accelerator (LINAC) multi-leaf collimator (MLC). Read More

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December 2018
1 Read

Preliminary experience of the use of high-resolution skin ultrasound for the evaluation of extrathyroideal manifestations of Graves' disease and response to UVA-1 phototherapy.

Photodermatol Photoimmunol Photomed 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.

Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema. Read More

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December 2018
2 Reads

Impact of image averaging on wide-field choroidal thickness measurements using enhanced-depth imaging optical coherence tomography.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.

Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More

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December 2018

Multimodal imaging of foveal neovascularisation in diabetic retinopathy.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Vitreo-Retinal Department, Drishti Eye Institute, Dehradun, India.

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December 2018
1 Read

VII. MATERNAL SECURE BASE SCRIPT KNOWLEDGE AND JUDGMENTS OF MOTHER-CHILD INTERACTIONS.

Monogr Soc Res Child Dev 2018 Dec;83(4):106-120

Previous studies have shown that mothers with high script scores are better at providing secure base support in naturalistic settings. In the current study, we examine whether maternal script knowledge guides mothers' expectations and judgments of mother-child interactions, providing a bridge between their knowledge and behavior. Forty mothers were asked to use a new Parental Secure Base Q-set designed to characterize a typical mother-child play day at a park. Read More

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December 2018
1 Read

Lipid Lowering and Incidence of Cataract, a Role for Fibrates.

Clin Pharmacol Ther 2018 Dec 5. Epub 2018 Dec 5.

Epidemiology and Preventive Pharmacology Centre, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

Cataract is a pathological eye condition with loss of lens transparency. Age-related cataract is the most common type in adults, and opacity is believed to result from oxidative stress. According to estimates by the World Health Organization, cataract affects ≈100 million people worldwide. Read More

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December 2018
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The Ocular Status of Cystinosis Patients Receiving a Hospital Pharmacy-Made Preparation of Cysteamine Eye Drops: A Case Series.

Ophthalmol Ther 2018 Dec 5. Epub 2018 Dec 5.

Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.

Introduction: Infantile nephropathic cystinosis (INC) is an autosomal recessive lysosomal disorder in which patients develop deposits of cystine crystals in their kidneys and corneas from a young age.

Methods: We conducted a retrospective analysis of children with INC seen by ophthalmologists at the Manchester Royal Eye Hospital between 2002 and 2018, to evaluate clinical findings, symptoms and treatment.

Results: Twenty-two children diagnosed with INC from age 0 (prenatally) to 11 years were assessed. Read More

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December 2018
2 Reads

Sodium fluoride induces apoptosis and autophagy via the endoplasmic reticulum stress pathway in MC3T3-E1 osteoblastic cells.

Mol Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Stomatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Fluorosis and bone pathologies can be caused by chronic and/or excessive fluoride intake. Despite this, few studies have been conducted on the cellular mechanisms underlying osteoblast toxicity in the presence of NaF. Here, we investigated the effects of fluoride on MC3T3-E1 cells. Read More

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December 2018
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A literature review concerning contralateral approaches to paraclinoid internal carotid artery aneurysms.

Neurosurg Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131, Mainz, Germany.

Ipsilateral approaches remain the standard technique for clipping paraclinoid aneurysms. Surgeons must however be prepared to deal with bony and neural structures restricting accessibility. The application of a contralateral approach has been proposed claiming that some structures in the region can be better exposed from this side. Read More

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December 2018
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Epithelial ingrowth through venting incision into laser-assisted in situ keratomileusis flap interface after descemet stripping automated endothelial keratoplasty.

Am J Ophthalmol Case Rep 2019 Mar 14;13:25-27. Epub 2018 Nov 14.

Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA.

Purpose: To present a case of epithelial ingrowth into the laser-assisted in situ keratomileusis (LASIK) flap interface after a patient underwent descemet stripping automated endothelial keratoplasty (DSAEK) surgery with venting incisions.

Observations: We present a case of a 48-year-old man with previous history of LASIK that underwent DSAEK for pseudophakic bullous keratopathy after complicated cataract surgery requiring an intraocular lens (IOL) exchange. The patient developed epithelial ingrowth into the LASIK flap interface from one of the venting incisions. Read More

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Hypertensive crisis with massive retinal and choroidal infarction: A case update.

Am J Ophthalmol Case Rep 2019 Mar 10;13:22-24. Epub 2018 Nov 10.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.

Purpose: We report an update on a recently published case of uncontrolled hypertension secondary to immunoglobulin A (IgA) nephropathy resulting in massive bilateral retinal and choroidal infarction.

Observations: In our previous report, we presented a 30-year old female with end-stage renal disease who complained of painless vision loss after many missed hemodialysis. The patient was found to be in hypertensive crisis resulting in massive retinal and choroidal infarction with severe vision loss in both eyes. Read More

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March 2019
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Loss of horizontal macular ganglion cell complex asymmetry: an optical coherence tomography indicator of chiasmal compression.

BMJ Open Ophthalmol 2018 25;3(1):e000195. Epub 2018 Oct 25.

Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway.

Objective: To estimate the macular ganglion cell complex (GCC) asymmetry in patients with suprasellar tumours, to compare its diagnostic performance to the nasal GCC thickness and visual field (VF) and to investigate how the parameters correlate with magnetic resonance imaging (MRI) findings.

Methods And Analysis: Cross-sectional study of patients with suprasellar tumours affecting the optic chiasm. Macular optical coherence tomography (OCT) scans were evaluated for nasal GCC sector thinning and loss of normal GCC asymmetry between corresponding nasal-temporal sectors. Read More

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October 2018
1 Read

Increased sensitivity of microbiological testing of cornea organ culture medium by additional resin treatment.

BMJ Open Ophthalmol 2018 10;3(1):e000173. Epub 2018 Nov 10.

Institute for Transfusion Medicine, University Tissue Bank, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: This validation study investigates the treatment of cornea organ culture medium (Modified Eagle Medium, Biochrom GmbH, Berlin, Germany) with RESEP, a new medical device for antibiotics removal, before microbiological testing with BACTEC blood culture bottles.

Methods And Analysis: 10-100 colony forming units of and were inoculated in 9mL of cornea organ culture medium. In group A, the medium was withdrawn with RESEP and treated for 20 min at room temperature, and then inoculated in BACTEC Plus Aerobic/F/Anaerobic/F blood culture bottles. Read More

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November 2018
2 Reads

Simultaneous EEG, eye-tracking, behavioral, and screen-capture data during online German language learning.

Data Brief 2018 Dec 13;21:1937-1943. Epub 2018 Nov 13.

Thayer School of Engineering at Dartmouth, 14 Engineering Drive, Hanover, NH 03755, United States.

This article presents concurrent multimodal data, including EEG, eye-tracking, and behavioral data (cursor movements and clicks), acquired from individuals ( = 22) while engaging in several German language lessons using the web-based Duolingo interface. Lessons were restricted to visual learning only (excluding audio and speech components), including reading and writing vocabulary words and sentences, and matching vocabulary to images. EEG data was collected using the open-source OpenBCI device utilizing dry Ag-AgCl electrodes, while eye-tracking data was recorded using the Gazepoint GP3 system. Read More

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December 2018

Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux.

Biomed Res Int 2018 1;2018:7627329. Epub 2018 Nov 1.

GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India.

Dry eye disease (DED) is a multifactorial ocular surface disorder affecting millions of individuals worldwide. Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition. In this study, we have explored the anti-inflammatory and autophagy modulating effect of chloroquine (CQ) in human corneal epithelial and human corneal fibroblasts cells exposed to desiccation stress, (an model for DED). Read More

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November 2018

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Transl Vis Sci Technol 2018 Nov 30;7(6):18. Epub 2018 Nov 30.

Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Purpose: We correlate optical coherence tomography (OCT) retinal layer thickness measurements with histology in wild-type and retinal degenerative pigs.

Methods: OCT scans were obtained using the Bioptigen Envisu R2200. In normal pigs, three eyes were imaged in vivo, and three eyes were imaged after enucleation. Read More

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November 2018
1 Read
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