11,302 results match your criteria Optic Atrophy


Measurement of The Inner Macular Layers for Monitoring of Glaucoma: Confounding Effects of Age-Related Macular Degeneration.

Ophthalmol Glaucoma 2022 Jun 21. Epub 2022 Jun 21.

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address:

Objective: To investigate the confounding effect of non-exudative age-related macular degeneration (AMD), specifically drusen and outer retinal atrophy, on the architecture and automated segmentation of the inner retinal layers as measured with optical coherence tomography (OCT).

Study Design: Observational cross-sectional study.

Subjects: 265 consecutive eyes with non-exudative AMD were identified through retrospective chart review. Read More

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Generation of functional human oligodendrocytes from dermal fibroblasts by direct lineage conversion.

Development 2022 Oct 24;149(20). Epub 2022 Jun 24.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Oligodendrocytes, the myelinating cells of the central nervous system, possess great potential for disease modeling and cell transplantation-based therapies for leukodystrophies. However, caveats to oligodendrocyte differentiation protocols ( Ehrlich et al., 2017; Wang et al. Read More

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October 2022

Biallelic Optic Atrophy 1 () Related Disorder-Case Report and Literature Review.

Genes (Basel) 2022 Jun 2;13(6). Epub 2022 Jun 2.

Pediatric Ophthalmology and Strabismus, Inherited Eye Disease, University of Iowa Hospitals and Clinics, Iowa, IA 52242, USA.

Dominant optic atrophy (DOA), MIM # 605290, is the most common hereditary optic neuropathy inherited in an autosomal dominant pattern. Clinically, it presents a progressive decrease in vision, central visual field defects, and retinal ganglion cell loss. A biallelic mode of inheritance causes syndromic DOA or Behr phenotype, MIM # 605290. Read More

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Characteristics of the Optic Nerve Head in Myopic Eyes Using Swept-Source Optical Coherence Tomography.

Invest Ophthalmol Vis Sci 2022 Jun;63(6):20

The Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.

Purpose: To investigate the characteristics of the optic nerve head (ONH) in myopia using swept-source optical coherence tomography (SS-OCT).

Methods: Participants were divided into three groups according to the axial length (AL). The optic disc morphology, retinal nerve fiber layer (RNFL) thickness, and radial peripapillary capillary (RPC) vessel density (VD), optic disc tilt, rotation, Bruch's membrane opening distance (BMOD), border length (BL), border tissue angle, focal lamina cribrosa (LC) defects, β- and γ-zone peripapillary atrophy (PPA), microvasculature dropout (MvD), choroidal thickness (CT), and the choroidal vascularity index (CVI) were compared. Read More

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The epidemiology and mutation types of Leber's hereditary optic neuropathy in Thailand.

Ann Med 2022 Dec;54(1):1601-1607

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: Leber's hereditary optic neuropathy (LHON), the most common mitochondrial optic neuropathy, causes visual loss, especially in young adults. Due to the absence of epidemiological data in Southeast Asia, we aimed to determine Thai LHON patients' characteristics (demographic data, mutation types, and prognoses) as the first study in this region.

Methods: This retrospective chart review enrolled all Thai LHON patients confirmed by three mitochondrial DNA mutations (G11778A, T14484C, and G3460A) between January 1997 and December 2016. Read More

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December 2022

Case Report: Optic Atrophy and Nephropathy With m.13513G>A/MT-ND5 mtDNA Pathogenic Variant.

Front Genet 2022 3;13:887696. Epub 2022 Jun 3.

Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy.

Isolated complex I deficiency represents the most common mitochondrial respiratory chain defect involved in mitochondrial disorders. Among these, the mitochondrial DNA (mtDNA) m.13513G>A pathogenic variant in the NADH dehydrogenase 5 subunit gene (MT-ND5) has been associated with heterogenous manifestations, including phenotypic overlaps of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes, Leigh syndrome, and Leber's hereditary optic neuropathy (LHON). Read More

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Size and position of the optic disc crescent in a white European population with myopia.

Ophthalmic Physiol Opt 2022 Jun 20. Epub 2022 Jun 20.

School of Optometry, Aston University, Birmingham, UK.

Significance: One of the first clinically observed changes in the retina with progressing myopia is in the form of optic disc crescents. If such a change is predictive of myopia progression, it could aid in myopia management interventions to target those at greatest risk of progression and subsequent ocular morbidity.

Purpose: To investigate the type, dimension and appearance of optic disc crescents and how they relate to the level of myopia. Read More

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Comparison between frequency-doubling technology perimetry and standard automated perimetry in early glaucoma.

Sci Rep 2022 Jun 17;12(1):10173. Epub 2022 Jun 17.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, South Korea.

This study aimed to find out the significance of the difference between frequency-doubling technology perimetry (FDT) and standard automated perimetry (SAP) in terms of the detected visual field (VF) damage, and evaluate associated factors to SAP-FDT difference in early glaucoma. Glaucoma patients in early stage (MD better than - 6.0 decibel, 96 eyes) were included in this cross-sectional study. Read More

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Multimodal Imaging of Rift Valley Fever Outer Retinitis.

Ocul Immunol Inflamm 2022 Jun 16:1-5. Epub 2022 Jun 16.

Eye Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates.

Purpose: To report a case of Rift Valley Fever retinitis studied with multimodal imaging.

Method: A 50-years-old man from Sudan, diagnosed with Rift Valley fever, presented with complete loss of vision in the right eye and visual impairment in the left. Multimodal imaging was performed at baseline and follow-up. Read More

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Mixed B- and T-lymphocyte Vitreous Infiltrate in Multiple Sclerosis Associated Uveitis.

Ocul Immunol Inflamm 2022 Jun 16:1-3. Epub 2022 Jun 16.

Uveitis Service, LV Prasad Eye Institute, Hyderabad, India.

A 23-year-old man, under treatment for relapsing remitting multiple sclerosis, presented with sudden drop in vision in the left eye for the past 1 week. We noted optic atrophy with sclerosed vessels in multiple quadrants in both eyes, moderate vitreous haze, and active retinal vasculitis in left eye. The patient received therapeutic pars plana vitrectomy in the left eye, and the vitreous sample was analyzed for immunophenotypes by flow cytometry (T-cells) and immunohistochemistry (B-cells). Read More

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An Artificial-Intelligence-Based Automated Grading and Lesions Segmentation System for Myopic Maculopathy Based on Color Fundus Photographs.

Transl Vis Sci Technol 2022 Jun;11(6):16

Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.

Purpose: To develop deep learning models based on color fundus photographs that can automatically grade myopic maculopathy, diagnose pathologic myopia, and identify and segment myopia-related lesions.

Methods: Photographs were graded and annotated by four ophthalmologists and were then divided into a high-consistency subgroup or a low-consistency subgroup according to the consistency between the results of the graders. ResNet-50 network was used to develop the classification model, and DeepLabv3+ network was used to develop the segmentation model for lesion identification. Read More

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Longitudinal retinal changes in MOGAD.

Ann Neurol 2022 Jun 15. Epub 2022 Jun 15.

Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

Objective: Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent retinal atrophy can be detected in MOGAD.

Methods: Eighty MOGAD patients and 139 healthy controls (HC) were included. Read More

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Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma.

Sci Rep 2022 Jun 13;12(1):9802. Epub 2022 Jun 13.

Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, Takara-mach13-1, Kanazawa, Ishikawa-ken, 920-8641, Japan.

A prospective study was conducted on 33 eyes of 33 patients with open-angle glaucoma who underwent trabeculectomy to investigate hemodynamic changes in the temporal optic nerve head (ONH) and peripapillary atrophy (PPA) after trabeculectomy. Laser speckle flowgraphy of ONH and PPA was performed at baseline and at 1, 3, and 6 months postoperatively. The waveforms of the mean blur rate in the tissue area (MT) in the temporal ONH, βPPA (with Bruch's membrane), and γPPA (without Bruch's membrane) were evaluated. Read More

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Charcot-Marie-Tooth Disease and Implications on Corneal Refractive Surgery.

Ophthalmol Ther 2022 Jun 11. Epub 2022 Jun 11.

Hoopes Vision Research Center, Hoopes Vision, 11820 S. State Street Suite #200, Draper, UT, 84020, USA.

Charcot-Marie-Tooth (CMT) disease is the most common inherited polyneuropathy, with a characteristic phenotype of distal muscle weakness, atrophy, and sensory loss. Variable ocular involvement has been documented in patients with CMT, with optic atrophy as the most frequently reported symptom. Although the Charcot-Marie-Tooth Association has generally deemed laser-assisted in situ keratomileuses (LASIK) a safe option for patients with CMT, reports of corneal refractive surgery are lacking in this patient population. Read More

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The Consequences of Mitochondrial T10432C Mutation in Cika Cattle: A "Potential" Model for Leber's Hereditary Optic Neuropathy.

Int J Mol Sci 2022 Jun 6;23(11). Epub 2022 Jun 6.

Department of Animal Science, Faculty of Agriculture, University of Zagreb, 10000 Zagreb, Croatia.

While mitogenome mutations leading to pathological manifestations are rare, more than 200 such mutations have been described in humans. In contrast, pathogenic mitogenome mutations are rare in domestic animals and have not been described at all in cattle. In the small local Slovenian cattle breed Cika, we identified (next-generation sequencing) two cows with the T10432C mitogenome mutation in the ND4L gene, which corresponds to the human T10663C mutation known to cause Leber's hereditary optic neuropathy (LHON). Read More

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Multishell Diffusion MR Tractography Yields Morphological and Microstructural Information of the Anterior Optic Pathway: A Proof-of-Concept Study in Patients with Leber's Hereditary Optic Neuropathy.

Int J Environ Res Public Health 2022 06 5;19(11). Epub 2022 Jun 5.

Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40138 Bologna, Italy.

Tractography based on multishell diffusion-weighted magnetic resonance imaging (DWI) can be used to estimate the course of myelinated white matter tracts and nerves, yielding valuable information regarding normal anatomy and variability. DWI is sensitive to the local tissue microstructure, so tractography can be used to estimate tissue properties within nerve tracts at a resolution of millimeters. This study aimed to test the applicability of the method using a disease with a well-established pattern of myelinated nerve involvement. Read More

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Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway.

Evid Based Complement Alternat Med 2022 21;2022:5812105. Epub 2022 May 21.

Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.

Background: Chronic kidney disease (CKD) is a major public health problem worldwide. Treatment with renin-angiotensin system inhibitors can achieve only partial efficacy on renal function decline and renal fibrosis in CKD patients. Huangqi-Danshen decoction (HDD) is a basic Chinese herbal pair which is commonly used to treat CKD with good efficacy. Read More

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Optic Nerve Atrophy in Syndromic Craniosynostosis.

Plast Reconstr Surg 2022 Jun 8. Epub 2022 Jun 8.

Department of Clinical Research, Medical City Dallas Hospital, Dallas, TX.

Background: Numerous children born with syndromic craniosynostosis will develop visual impairments. Based on the hypothesis that elevations in intracranial pressure might have greater impacts on vision than development, this review sought to ascertain the prevalence of optic nerve atrophy in syndromic craniosynostosis and to look for potential predictive factors.

Methods: A retrospective chart review of all children with syndromic craniosynostosis treated at a single center. Read More

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Prohibitin 1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers.

J Ovarian Res 2022 Jun 7;15(1):70. Epub 2022 Jun 7.

Departments of Obstetrics and Gynecology and Cellular and Molecular Medicine, Interdisciplinary School of Health Sciences University of Ottawa, and Chronic Disease Program, Ottawa Hospital Research Institute, 501 Smyth Road, Mail Box #511, ON, K1H 8L6, Ottawa, Canada.

Background: Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Read More

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AAV-vector based gene therapy for mitochondrial disease: progress and future perspectives.

Orphanet J Rare Dis 2022 06 6;17(1):217. Epub 2022 Jun 6.

Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA.

Mitochondrial diseases are a group of rare, heterogeneous diseases caused by gene mutations in both nuclear and mitochondrial genomes that result in defects in mitochondrial function. They are responsible for significant morbidity and mortality as they affect multiple organ systems and particularly those with high energy-utilizing tissues, such as the nervous system, skeletal muscle, and cardiac muscle. Virtually no effective treatments exist for these patients, despite the urgent need. Read More

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The Predictive Values of Changes in Local and Remote Brain Functional Connectivity in Primary Angle-Closure Glaucoma Patients According to Support Vector Machine Analysis.

Front Hum Neurosci 2022 19;16:910669. Epub 2022 May 19.

Department of Ophthalmology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Purpose: The primary angle-closure glaucoma (PACG) is an irreversible blinding eye disease in the world. Previous neuroimaging studies demonstrated that PACG patients were associated with cerebral changes. However, the effect of optic atrophy on local and remote brain functional connectivity in PACG patients remains unknown. Read More

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Low- and Very Low-Dose Bevacizumab for Retinopathy of Prematurity: Reactivations, Additional Treatments, and 12-Month Outcomes.

Ophthalmology 2022 May 31. Epub 2022 May 31.

University of Arizona, Tucson, AZ.

Objective: Low-dose and very low-dose intravitreal bevacizumab (IVB) have been reported successful in short-term treatment of type 1 retinopathy of prematurity (ROP), down to an initial dose of 0.004 mg. We now report 12-month outcomes for these infants. Read More

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Is the pathology of posterior cortical atrophy clinically predictable?

Rev Neurosci 2022 Jun 6. Epub 2022 Jun 6.

Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", P.zza L. Miraglia 2, 80138 Naples, Italy.

Posterior cortical atrophy (PCA) is a neurodegenerative disorder characterized by an early prominent deficit of visual functions associated with signs and symptoms that are the expression of dysfunction of posterior brain regions. Although PCA is commonly associated with Alzheimer's disease (AD), in recent years new pathological substrates have emerged. Among them, frontotemporal lobar degeneration (FTLD) is the most commonly reported but, to date, little is known about the clinical features of PCA due to FTLD. Read More

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A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration.

Aging Cell 2022 Jun 3:e13645. Epub 2022 Jun 3.

IGMM, Univ Montpellier, CNRS, Montpellier, France.

Most neurodegenerative diseases such as Alzheimer's disease are proteinopathies linked to the toxicity of amyloid oligomers. Treatments to delay or cure these diseases are lacking. Using budding yeast, we report that the natural lipid tripentadecanoin induces expression of the nitric oxide oxidoreductase Yhb1 to prevent the formation of protein aggregates during aging and extends replicative lifespan. Read More

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Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells.

Hum Mol Genet 2022 Jun 2. Epub 2022 Jun 2.

UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL.

Autosomal dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the preferential loss of retinal ganglion cells (RGCs), resulting in optic nerve degeneration and progressive bilateral central vision loss. Over 60% of genetically confirmed DOA patients carry variants in the nuclear OPA1 gene, which encodes for a ubiquitously expressed, mitochondrial GTPase protein. OPA1 has diverse functions within the mitochondrial network, facilitating inner membrane fusion and cristae modelling, regulating mitochondrial DNA maintenance and coordinating mitochondrial bioenergetics. Read More

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A case of bilateral uveitis associated with seminoma/germinoma in thymus and pineal glands, two primary lesions.

Am J Ophthalmol Case Rep 2022 Sep 18;27:101589. Epub 2022 May 18.

Division of Ophthalmology, Shinseikai Toyama Hospital, Imizu, Toyama, Japan.

Purpose: To report a case of bilateral ocular paraneoplastic syndrome by seminoma/germinoma in thymus and pineal glands, two primary lesions.

Observations: A 18-year-old male presented at a local clinic complaining of just floaters in left eye without any other clinical signs and symptoms. The treating ophthalmologist found bilateral uveitis, and referred to our hospital. Read More

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September 2022

Brain Gray Matter Atrophy and Functional Connectivity Remodeling in Patients With Chronic LHON.

Front Neurosci 2022 12;16:885770. Epub 2022 May 12.

Department of Radiology, Tianjin Medical University, Tianjin, China.

Purpose: The aim of this study was to investigate the brain gray matter volume (GMV) and spontaneous functional connectivity (FC) changes in patients with chronic Leber's hereditary optic neuropathy (LHON), and their relations with clinical measures.

Methods: A total of 32 patients with chronic LHON and matched sighted healthy controls (HC) underwent neuro-ophthalmologic examinations and multimodel magnetic resonance imaging (MRI) scans. Voxel-based morphometry (VBM) was used to detect the GMV differences between the LHON and HC. Read More

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Ocular malignancies treated with iodine-125 low dose rate (LDR) brachytherapy at a single high-volume institution: A retrospective review.

Med Dosim 2022 May 26. Epub 2022 May 26.

Department of Radiation Oncology, Texas Oncology, Brownsville, TX, USA.

The aim of our study is to document our cases of choroidal melanoma treated with low dose rate (LDR) brachytherapy and to correlate the dosimetry and radiobiology with clinical effects and oncologic outcomes. Data from 157 patients treated from 2014 to 2018 with LDR brachytherapy were used for this investigation. Treatments used a collaborative ocular melanoma study eye plaque and Iodine-125 radioactive seeds. Read More

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Photopic negative response recorded with RETeval system in eyes with optic nerve disorders.

Sci Rep 2022 May 31;12(1):9091. Epub 2022 May 31.

Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

Electroretinography (ERG) is used to evaluate the physiological status of the retina and optic nerve. The purpose of this study was to determine the usefulness of ERGs recorded with the RETeval system in diagnosing optic nerve diseases. Forty-eight patients with optic nerve disorders, including optic neuritis, ischemic optic neuropathy, traumatic optic neuropathy, and dominant optic atrophy, and 36 normal control subjects were studied. Read More

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Unilateral Compressive Optic Neuropathy As the Presenting Manifestation of Clival Chordoma: A Case Report.

Cureus 2022 Apr 24;14(4):e24440. Epub 2022 Apr 24.

Ophthalmology, Houston Methodist Hospital, Houston, USA.

The optic nerve(s) may be compressed by a number of intracranial and intraorbital masses. Compression may be isolated to the optic nerve or may involve other intracranial or intraorbital structures with variable presentation. A 26-year-old man presented with complaints of progressive painless visual loss in the right eye for eight months. Read More

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