29,825 results match your criteria Opioid Abuse


Mu opioid receptors in the medial habenula contribute to naloxone aversion.

Neuropsychopharmacology 2019 Apr 20. Epub 2019 Apr 20.

McGill University, Faculty of Medicine, Douglas Research Centre, Montreal, Canada.

The medial habenula (MHb) is considered a brain center regulating aversive states. The mu opioid receptor (MOR) has been traditionally studied at the level of nociceptive and mesolimbic circuits, for key roles in pain relief and reward processing. MOR is also densely expressed in MHb, however, MOR function at this brain site is virtually unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0395-7DOI Listing
April 2019
1 Read

Changes in State Technical Assistance Priorities and Block Grant Funds for Addiction After ACA Implementation.

Am J Public Health 2019 Apr 18:e1-e7. Epub 2019 Apr 18.

Amanda J. Abraham is with the School of Public and International Affairs, University of Georgia, Athens. Bikki Tran Smith, Colleen M. Grogan, and Harold A. Pollack are with the School of Social Service Administration, University of Chicago, Chicago, IL. Christina M. Andrews is with the College of Social Work, University of South Carolina, Columbia. Clifford S. Bersamira is with the Myron B. Thompson School of Social Work, University of Hawai'i at Mānoa, Honolulu. Peter D. Friedmann is with the University of Massachusetts Medical School Baystate, Springfield.

To assess states' provision of technical assistance and allocation of block grants for treatment, prevention, and outreach after the expansion of health insurance coverage for addiction treatment in the United States under the Affordable Care Act (ACA). We used 2 waves of survey data collected from Single State Agencies in 2014 and 2017 as part of the National Drug Abuse Treatment System Survey. The percentage of states providing technical assistance for cross-sector collaboration and workforce development increased. Read More

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http://dx.doi.org/10.2105/AJPH.2019.305052DOI Listing

Is thrombotic event a side effect of oral buprenorphine abuse? Two case reports.

Clin Case Rep 2019 Apr 3;7(4):740-743. Epub 2019 Mar 3.

Cardiology Department of Shohaday-e-Tajrish Hospital Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran.

Buprenorphine is used to treat opioid addiction. The spectrum of complications of oral buprenorphine is not well known. We describe two cases and based on a hypothesis is proposed which suggests that the use of oral buprenorphine could be relevant to the increase of thrombotic risk. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2086
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http://dx.doi.org/10.1002/ccr3.2086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452464PMC
April 2019
1 Read

Impact of abstinence and of reducing illicit drug use without abstinence on HIV viral load.

Clin Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington, Seattle, WA.

Background: Substance use is common among people living with HIV (PLWH) and a barrier to achieving viral suppression.

Objective: Among PLWH who report illicit drug use, we evaluated associations between HIV viral load (VL) and reduced use of illicit opioids, methamphetamine/crystal, cocaine/crack, and marijuana, regardless of whether or not abstinence was achieved.

Design: Longitudinal cohort studySetting/participantsPLWH in clinical care at 8 HIV clinics or 5 clinical studies. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz299DOI Listing
April 2019
1 Read

New Persistent Opioid Use Following Common Forefoot Procedures for the Treatment of Hallux Valgus.

J Bone Joint Surg Am 2019 Apr;101(8):722-729

Departments of Orthopaedic Surgery (F.T.F, T.D.G., P.G.T., and J.R.H.), Surgery (H.M.H. and J.F.W.), and Anesthesiology (C.M.B.), University of Michigan, Ann Arbor, Michigan.

Background: Orthopaedic surgeons are the fourth highest on the list of top prescribers of opioid analgesics by specialty and have a direct impact on opioid-related morbidity in the United States. Operative bunion correction is one of the most commonly performed elective foot surgical procedures in this country. We sought to determine the rate of new persistent opioid use following exposure to opioids after surgical treatment of hallux valgus (bunionectomy) and to identify associated risk factors. Read More

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http://dx.doi.org/10.2106/JBJS.18.00793DOI Listing

Worries About Discontinuing Buprenorphine Treatment: Scale Development and Clinical Correlates.

Am J Addict 2019 Apr 16. Epub 2019 Apr 16.

Department of Behavioral Medicine and Addictions Resaerch, Butler Hospital, Providence, Rhode Island.

Background And Objectives: Despite the benefits of maintenance buprenorphine treatment for opioid use disorder (OUD), many individuals report an interest in discontinuing the medication, while also expressing worries about tapering. The purpose of this study was to develop a measure of worries about buprenorphine discontinuation ("Off Bupe") and determine the demographic and clinical characteristics associated with these worries.

Methods: Between May 2017 and May 2018, we surveyed adults in an outpatient primary care buprenorphine program (n = 138). Read More

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http://dx.doi.org/10.1111/ajad.12884DOI Listing
April 2019
1 Read

A Machine Learning-based Approach for Collaborative Non-Adherence Detection during Opioid Abuse Surveillance using a Wearable Biosensor.

Biomed Eng Syst Technol Int Jt Conf BIOSTEC Revis Sel Pap 2019 Feb;5:310-318

Worcester Polytechnic Institute, Worcester, MA, U.S.A.

Wearable biosensors can be used to monitor opioid use, a problem of dire societal consequence given the current opioid epidemic in the US. Such surveillance can prompt interventions that promote behavioral change. The effectiveness of biosensor-based monitoring is threatened by the potential of a patient's to the monitoring. Read More

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http://dx.doi.org/10.5220/0007382503100318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461698PMC
February 2019

Syringeability of morphine ARER, a novel, abuse-deterrent, extended-release morphine formulation.

Am J Drug Alcohol Abuse 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Inspirion Delivery Sciences , LLC , Morristown , NJ , USA.

Background: Extended-release (ER) morphine formulations are commonly manipulated for non-oral routes of administration, particularly via injection. Morphine ARER, an abuse-deterrent formulation of ER morphine, has both physical and chemical properties that deter abuse.

Objectives: To assess the syringeability of morphine ARER using in vitro laboratory studies. Read More

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https://www.tandfonline.com/doi/full/10.1080/00952990.2019.1
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http://dx.doi.org/10.1080/00952990.2019.1599383DOI Listing
April 2019
5 Reads

Overexpression of miR-9 in the nucleus accumbens increases oxycodone self-administration.

Int J Neuropsychopharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, U.S.A.

Background: There is an urgent need to identify factors that increase vulnerability to opioid addiction to help stem the opioid epidemic and develop more efficient pharmacotherapeutics. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at a posttranscriptional level and have been implicated in chronic drug-taking in humans and in rodent models. Recent evidence has shown that chronic opioid treatment regulates the microRNA miR-9. Read More

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https://academic.oup.com/ijnp/advance-article/doi/10.1093/ij
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http://dx.doi.org/10.1093/ijnp/pyz015DOI Listing
April 2019
2 Reads

Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.

Pain Med 2019 Apr 15. Epub 2019 Apr 15.

Vince & Associates, Overland Park, Kansas, USA.

Objectives: Hydromorphone (HM) is a potent μ-opioid receptor agonist with high susceptibility for abuse. A prodrug of hydromorphone, asalhydromorphone (ASAL-HM), has been designed to deter nonoral forms of abuse associated with hydromorphone. This study evaluated the intranasal (IN) pharmacokinetics and exploratory abuse potential of ASAL-HM compared with HM. Read More

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http://dx.doi.org/10.1093/pm/pnz066DOI Listing
April 2019
1 Read

Assessing treatment and monitoring of musculoskeletal conditions using opioid versus nonopioid therapy: A cross-sectional study.

Medicine (Baltimore) 2019 Apr;98(15):e15128

Central Michigan University (CMU) College of Medicine, Mt. Pleasant, MI.

The purpose of this study is to examine the treatment of noncancer musculoskeletal pain in different clinical settings by assessing patient demographics, pain diagnoses, opioid analgesic monitoring, and alternative treatments.Data was collected in a retrospective chart review involving 300 randomly selected charts with an active musculoskeletal diagnosis based on the 10th revision of the International Statistical Classification of Diseases and Related Health Problems codes. The population consisted of primary care outpatient clinic and emergency department encounters during the timeframe of January 1, 2016 to March 31, 2016 in a predominantly rural community in Michigan. Read More

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http://dx.doi.org/10.1097/MD.0000000000015128DOI Listing
April 2019
2 Reads

OPRM1 rs1799971 - COMT rs4680 - FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia.

Pain 2019 May 6. Epub 2019 May 6.

Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, USA.

Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded upon previous findings related to the three SNPs in the opioid receptor mu subunit (OPRM1 rs1799971), catechol-O-methyltransferase (COMT rs4680), and fatty acid amide hydrolase (FAAH rs324420) genes associated with placebo hypoalgesia and tested the effect of a three-way interaction on placebo hypoalgesia. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001578DOI Listing
May 2019
1 Read

Inappropriate opioid prescription after surgery.

Lancet 2019 Apr;393(10180):1547-1557

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada; Department of Anesthesia and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Worldwide, the use of prescription opioid analgesics more than doubled between 2001 and 2013, with several countries, including the USA, Canada, and Australia, experiencing epidemics of opioid misuse and abuse over this period. In this context, excessive prescribing of opioids for pain treatment after surgery has been recognised as an important concern for public health and a potential contributor to patterns of opioid misuse and related harm. In the second paper in this Series we review the evolution of prescription opioid use for pain treatment after surgery in the USA, Canada, and other countries. Read More

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http://dx.doi.org/10.1016/S0140-6736(19)30428-3DOI Listing
April 2019
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Transition from acute to chronic pain after surgery.

Lancet 2019 Apr;393(10180):1537-1546

Department of Anaesthesiology and Perioperative Medicine, Alfred Hospital, Melbourne, VIC. Electronic address:

Over the past decade there has been an increasing reliance on strong opioids to treat acute and chronic pain, which has been associated with a rising epidemic of prescription opioid misuse, abuse, and overdose-related deaths. Deaths from prescription opioids have more than quadrupled in the USA since 1999, and this pattern is now occurring globally. Inappropriate opioid prescribing after surgery, particularly after discharge, is a major cause of this problem. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01406736193035
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http://dx.doi.org/10.1016/S0140-6736(19)30352-6DOI Listing
April 2019
2 Reads

Frequent emergency department use and mortality in patients with substance and opioid use in Alberta: A population-based retrospective cohort study.

CJEM 2019 Apr 15:1-10. Epub 2019 Apr 15.

**Department of Emergency Medicine,University of Alberta,Edmonton,AB.

Objectives: In the current opioid epidemic, identifying high-risk patients among those with substance and opioid use may prevent deaths. The objective of this study was to determine whether frequent emergency department (ED) use and degree of frequent use are associated with mortality among ED patients with substance and opioid use.

Methods: This cohort study used linked population-based ED (National Ambulatory Care Reporting System) and mortality data from Alberta. Read More

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http://dx.doi.org/10.1017/cem.2019.15DOI Listing
April 2019
1 Read

Upper-Extremity Nerve Decompression Under Local Anesthesia: A Systematic Review of Methods for Reduction of Postoperative Pain and Opioid Consumption.

Hand (N Y) 2019 Apr 15:1558944719843635. Epub 2019 Apr 15.

2 Division of Plastic & Reconstructive Surgery, McGill University Health Centre, Montreal, QC, Canada.

Background: Opioid abuse is a major health concern in North America. Data have shown an alarming increase in opioid-related deaths and complications, which has shed light on current prescription practices across many specialties, including hand surgery. To that end, we sought to conduct a focused literature review to determine the available modalities to decrease postoperative pain and opioid consumption following upper-extremity nerve decompression procedures, taking advantage of the homogeneity and inherent pain pathways of this specific patient cohort. Read More

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http://dx.doi.org/10.1177/1558944719843635DOI Listing
April 2019
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A conceptual model for understanding post-release opioid-related overdose risk.

Addict Sci Clin Pract 2019 Apr 15;14(1):17. Epub 2019 Apr 15.

Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

Post-release opioid-related overdose mortality is the leading cause of death among people released from jails or prisons (PRJP). Informed by the proximate determinants framework, this paper presents the Post-Release Opioid-Related Overdose Risk Model. It explores the underlying, intermediate, proximate and biological determinants which contribute to risk of post-release opioid-related overdose mortality. Read More

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https://ascpjournal.biomedcentral.com/articles/10.1186/s1372
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http://dx.doi.org/10.1186/s13722-019-0145-5DOI Listing
April 2019
2 Reads

A potential role for the gut microbiome in substance use disorders.

Psychopharmacology (Berl) 2019 Apr 14. Epub 2019 Apr 14.

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome, and the CNS. Read More

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http://link.springer.com/10.1007/s00213-019-05232-0
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http://dx.doi.org/10.1007/s00213-019-05232-0DOI Listing
April 2019
6 Reads

Δ-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.

Neuropharmacology 2019 Apr 11;151:127-135. Epub 2019 Apr 11.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. Electronic address:

Growing nonmedical use of prescription opioids is a global problem, motivating research on ways to reduce use and combat addiction. Medical cannabis ("medical marijuana") legalization has been associated epidemiologically with reduced opioid harms and cannabinoids have been shown to modulate effects of opioids in animal models. This study was conducted to determine if Δ-tetrahydrocannabinol (THC) enhances the behavioral effects of oxycodone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283908193012
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http://dx.doi.org/10.1016/j.neuropharm.2019.04.010DOI Listing
April 2019
3 Reads

Impact of pharmacological manipulation of the k-opioid receptor system on self-grooming and anhedonic-like behaviors in mice.

J Pharmacol Exp Ther 2019 Apr 11. Epub 2019 Apr 11.

The Rockefeller University.

The kappa (κ) opioid receptor / dynorphin system modulates depression-like states and anhedonia, as well adaptations to stress and exposure to drugs of abuse. Several relatively short-acting small molecule κreceptor antagonists have been synthesized, and their behavioral profile has been examined under some conditions. The hypothesis of this study is that pharmacological manipulations of the κ receptor system will result in changes ethologically relevant anhedonic-like behaviors in mice. Read More

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http://dx.doi.org/10.1124/jpet.119.256354DOI Listing
April 2019
2 Reads

Impact of Abuse Deterrent Formulations of Opioids in Patients With Chronic Pain in the United States: A Cost-Effectiveness Model.

Value Health 2019 Apr 21;22(4):416-422. Epub 2019 Mar 21.

Institute for Clinical and Economic Review, Boston, MA, USA.

Objective: Opioid abuse is a significant public health problem in the United States. We evaluate the clinical effectiveness and economic impact of abuse-deterrent formulations (ADF) of opioids relative to non-ADF opioids in preventing abuse.

Methods: We developed a cost-effectiveness model simulating 2 cohorts of 100 000 noncancer, chronic-pain patients newly prescribed either ADF or non-ADF extended-release (ER) opioids and followed them over 5 years, tracking new events of opioid abuse and opioid-related overdose deaths in addition to tracking 5-year cumulative costs of therapeutic use and abuse of ADF and non-ADF opioids. Read More

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http://dx.doi.org/10.1016/j.jval.2018.12.005DOI Listing
April 2019
1 Read

The highly selective dopamine DR antagonist, RVK4-40, attenuates oxycodone reward and augments analgesia in rodents.

Neuropharmacology 2019 Apr 8. Epub 2019 Apr 8.

Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA. Electronic address:

Prescription opioid abuse is a global crisis. New treatment strategies for pain and opioid use disorders are urgently required. We evaluated the effects of RVK4-40, a highly selective dopamine (DA) D receptor (DR) antagonist, on the rewarding and analgesic effects of oxycodone, the most commonly abused prescription opioid, in rats and mice. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.003DOI Listing
April 2019
1 Read

Preoperative Chronic Opioid Therapy Negatively Impacts Long Term Outcomes Following Cervical Fusion Surgery.

Spine (Phila Pa 1976) 2019 Apr 5. Epub 2019 Apr 5.

Spine Surgery, Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242.

MINI: The study investigates the association between preoperative chronic opioid therapy on long-term outcomes (reoperations, ED visits, postoperative opioid use, and adverse events)in patients undergoing primary cervical spine arthrodesis using a commercial claims dataset.

Study Design: Retrospective, observational.

Objective: To define the impact of preoperative chronic opioid therapy (COT) on outcomes following cervical spine fusions. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003064DOI Listing
April 2019
2 Reads

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.

Neuropsychopharmacology 2019 Apr 10. Epub 2019 Apr 10.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.

Alcohol use disorder (AUD) persists as a devastating public health problem; widely effective pharmacological treatments are needed. Evidence from rodent models suggests that stimulating brain receptors for the neuropeptide nociceptin/orphanin FQ (NOP) can decrease ethanol drinking. We characterized the effects of the mu opioid peptide (MOP) receptor agonist buprenorphine and the buprenorphine analog (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6 methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028), which stimulates MOP and NOP receptors, in a translational nonhuman primate model of AUD. Read More

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http://dx.doi.org/10.1038/s41386-019-0390-zDOI Listing
April 2019
1 Read

NOP-Related Mechanisms in Substance Use Disorders.

Handb Exp Pharmacol 2019 Apr 10. Epub 2019 Apr 10.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.

Nociceptin/orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995 and has been widely studied since. The role of the N/OFQ system in drug abuse has attracted researchers' attention since its initial discovery. The first two scientific papers describing the effect of intracranial injection of N/OFQ appeared 20 years ago and reported efficacy of the peptide in attenuating alcohol intake, whereas heroin self-administration was insensitive. Read More

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http://dx.doi.org/10.1007/164_2019_209DOI Listing
April 2019
1 Read

Ventricular Tachycardia Storm Induced by Loperamide Abuse.

Cureus 2019 Jan 29;11(1):e3981. Epub 2019 Jan 29.

Internal Medicine, University of Kansas School of Medicine, Wichita, USA.

A recent increase in the incidence of ventricular arrhythmias has been observed with the consumption of large dosages of the anti-diarrheal agent, loperamide. Our case is unique in that our patient not only displayed ventricular tachycardia (VT) but sustained VT (known as a VT storm). In this era of the opioid crisis, clinicians should be aware of all of the over-the-counter medications that have opioid-like side effects. Read More

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https://www.cureus.com/articles/17447-ventricular-tachycardi
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http://dx.doi.org/10.7759/cureus.3981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440553PMC
January 2019
2 Reads

Epidemiology of opioid-related visits to US Emergency Departments, 1999-2013: A retrospective study from the NHAMCS (National Hospital Ambulatory Medical Care Survey).

Am J Emerg Med 2019 Mar 31. Epub 2019 Mar 31.

Cooper Medical School of Rowan University, Department of Emergency Medicine, One Cooper Plaza, Camden, NJ, United States of America.

Goals: To characterize the epidemiology of opioid-related visits to United States (US) emergency departments (EDs) and describe trends in opioid-related visits over time.

Design: Retrospective cohort study CASES: The National Hospital Ambulatory Care Survey (NHAMCS) was used to identify opioid-related ED visits between 1999 and 2013.

Measurements: The NHAMCS is an annual, weighted, multi-stage survey which allows for the study of ambulatory care services within a nationally representative sample of US hospitals. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.03.052DOI Listing
March 2019
1 Read

Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats.

Neuropharmacology 2019 Apr 6. Epub 2019 Apr 6.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD, USA. Electronic address:

The current opioid overdose crisis is being exacerbated by illicitly manufactured fentanyl and its analogs. Carfentanil is a fentanyl analog that is 10,000-times more potent than morphine, but limited information is available about its pharmacology. The present study had two aims: 1) to validate a method for quantifying carfentanil and its metabolite norcarfentanil in small-volume samples, and 2) to use the method for examining pharmacodynamic-pharmacokinetic relationships in rats. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.002DOI Listing
April 2019
3 Reads

Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal.

Addict Biol 2019 Apr 9. Epub 2019 Apr 9.

Bowles Center for Alcohol Studies, UNC Chapel Hill School of Medicine, Chapel Hill, NC, USA.

The United States is experiencing an opioid crisis imposing enormous fiscal and societal costs and driving the staggering overdose death rate. While prescription opioid analgesics are essential for treating acute pain, cessation of use in individuals with a physical dependence induces an aversive withdrawal syndrome that promotes continued drug use to alleviate/avoid these symptoms. Additionally, repeated bouts of withdrawal often lead to an increased propensity for relapse. Read More

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http://dx.doi.org/10.1111/adb.12748DOI Listing
April 2019
1 Read

Retrospective Review of Need for Delayed Naloxone or Oxygen in Emergency Department Patients Receiving Naloxone for Heroin Reversal.

J Emerg Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Emergency Medicine, University of Louisville, Louisville, Kentucky.

Background: Emergency departments (EDs) are experiencing an increasing number of heroin overdose visits. Currently, there is no generally agreed upon ED observation period for heroin overdose patients who receive naloxone.

Objectives: We aimed to determine the safety of a 2-h observation period for heroin overdose patients who receive naloxone. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.02.015DOI Listing
April 2019
3 Reads

Intensive Models of Hepatitis C Care for People Who Inject Drugs Receiving Opioid Agonist Therapy: A Randomized Controlled Trial.

Ann Intern Med 2019 Apr 9. Epub 2019 Apr 9.

University of South Carolina School of Medicine-Greenville and Prisma Health-Upstate, Greenville, South Carolina, and Clemson University School of Health Research, Clemson, South Carolina (A.H.L.).

Background: Many people who inject drugs (PWID) are denied treatment for hepatitis C virus (HCV) infection, even if they are receiving opioid agonist therapy (OAT). Research suggests that HCV in PWID may be treated effectively, but optimal models of care for promoting adherence and sustained virologic response (SVR) have not been evaluated in the direct-acting antiviral (DAA) era.

Objective: To determine whether directly observed therapy (DOT) and group treatment (GT) are more effective than self-administered individual treatment (SIT) in promoting adherence and achieving SVR among PWID receiving OAT. Read More

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http://annals.org/article.aspx?doi=10.7326/M18-1715
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http://dx.doi.org/10.7326/M18-1715DOI Listing
April 2019
2 Reads
17.810 Impact Factor

Characteristics of doctor-shoppers: a systematic literature review.

J Mark Access Health Policy 2019 27;7(1):1595953. Epub 2019 Mar 27.

Faculty of Medicine, Aix-Marseille University, Marseilles, France.

: Doctor-shopping has significant consequences for patients and payers and can indicate misuse of drugs, polypharmacy, less continuity of care, and increased medical expenses. This study reviewed the literature describing doctor-shoppers in the adult population. : A systematic literature review was performed in PubMed and supplemented by a Google search of grey literature. Read More

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http://dx.doi.org/10.1080/20016689.2019.1595953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442108PMC
March 2019
1 Read

Association between harm reduction strategies and healthcare utilization in patients on long-term prescribed opioid therapy presenting to acute healthcare settings: a protocol for a systematic review and meta-analysis.

Syst Rev 2019 Apr 5;8(1):88. Epub 2019 Apr 5.

Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2-124E, Clinical Sciences Building, 8440-112 St, Edmonton, NW, T6G 2B7, Canada.

Introduction: Opioids are routinely used to treat a variety of chronic conditions associated with pain. However, they are a class of medications with a significant potential for adverse health effects, with and without misuse. Opioid misuse, as defined as inappropriate use of appropriately prescribed opioids, is becoming more well-recognized publicly but does not have clear treatment options. Read More

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http://dx.doi.org/10.1186/s13643-019-0997-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449896PMC
April 2019
2 Reads

Reasons for non-medical use of prescription opioids among young adults: Role of educational status.

Prev Med 2019 Apr 2. Epub 2019 Apr 2.

Vermont Center on Behavior and Health, 1 South Prospect Street, MS 482, Burlington, VT 05401, USA; Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect Street, MS 446AR6, Burlington, VT 05401, USA.

Non-medical use of prescription opioids (NMUPO) and related overdoses are disproportionately elevated among young adults. Efforts to understand the underlying reasons for NMUPO are critical for developing more effective prevention and intervention strategies for this group. Given the robust literature on the association between educational status and substance abuse risk, we examined the reasons for NMUPO through the lens of educational attainment among young adults. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.03.047DOI Listing
April 2019
1 Read

Screen of drug use: Diagnostic accuracy for opioid use disorder.

Drug Alcohol Depend 2019 May 18;198:176-179. Epub 2019 Mar 18.

VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA; Department of Psychiatry and Behavioral Sciences, Center for Health Care Evaluation, Stanford University School of Medicine, 152MPD, 795 Willow Road, Menlo Park, CA 94025, USA.

Aims: Opioid related deaths have more than tripled in recent years. Identifying and referring individuals with opioid use disorder (OUD) to treatment is one of the promising approaches to reduce opioid related deaths. However, using urine toxicology to identify opioid misuse is not reliable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03768716193007
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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.044DOI Listing
May 2019
6 Reads

Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect.

Addict Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.

Preclinical studies have shown effects of chronic exposure to addictive drugs on glutamatergic-mediated neuroplasticity in frontostriatal circuitry. These initial findings have been paralleled by human functional magnetic resonance imaging (fMRI) research demonstrating weaker frontostriatal resting-state functional connectivity (rsFC) among individuals with psychostimulant use disorders. However, there is a dearth of human imaging literature describing associations between long-term prescription opioid use, frontostriatal rsFC, and brain morphology among chronic pain patients. Read More

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http://dx.doi.org/10.1111/adb.12743DOI Listing
April 2019
2 Reads

Opioid and non-opioid utilization at home following gastrointestinal procedures: a prospective cohort study.

Surg Endosc 2019 Apr 3. Epub 2019 Apr 3.

Department of Psychiatry, University of Colorado/Anschutz Medical Campus, 12401 E. 17th Avenue, MS B-113, Aurora, CO, 80045, USA.

Background: Overprescribing of opioid medications for patients to be used at home after surgery is common. We sought to ascertain important patient and procedural characteristics that are associated with low versus high rates of self-reported utilization of opioids at home, 1-4 weeks after discharge following gastrointestinal surgery.

Methods: We developed a survey consisting of questions from NIH PROMIS tools for pain intensity/interference and queries on postoperative analgesic use. Read More

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http://dx.doi.org/10.1007/s00464-019-06767-1DOI Listing
April 2019
3 Reads

Alcohol and Cannabis Consumption Does Not Diminish Cure Rates in a Real-World Cohort of Chronic Hepatitis C Virus Infected Patients on Opioid Substitution Therapy-Data From the German Hepatitis C-Registry (DHC-R).

Subst Abuse 2019 28;13:1178221819835847. Epub 2019 Mar 28.

Leberstiftungs-GmbH Deutschland, Hannover, Germany.

Background: The importance of alcohol and cannabis consumption for the effectiveness of treatment of chronic hepatitis C virus (HCV) infection with direct acting antivirals (DAAs) in people on opioid substitution therapy (OST) has not been investigated in detail.

Methods: We investigated sustained virological response (SVR) rates and proportion of lost to follow-up (LTFU) between OST (n = 739) and non-OST patients (n = 7008) in the German Hepatitis C-Registry (Deutsches Hepatitis C-Register, DHC-R), which is a national multicenter prospective non-interventional real-world registry. Non-OST patients comprised patients with former/current drug use (non-OST/DU; n = 1500) and patients never consuming drugs (non-OST/NDU; n = 5508). Read More

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http://dx.doi.org/10.1177/1178221819835847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440029PMC
March 2019
4 Reads

Elective Shoulder Surgery in the Opioid Naïve: Rates of and Risk Factors for Long-term Postoperative Opioid Use.

Am J Sports Med 2019 Apr;47(5):1051-1056

Rothman Orthopaedic Institute, New York, New York, USA.

Background:: Little is known regarding the rates and risk factors for long-term postoperative opioid use among opioid-naïve patients undergoing elective shoulder surgery.

Purpose:: To identify (1) the proportion of opioid-naïve patients undergoing elective shoulder surgery, (2) the rates of postoperative opioid use among these patients, and (3) the risk factors associated with long-term postoperative opioid use.

Study Design:: Cohort study; Level of evidence, 3. Read More

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http://dx.doi.org/10.1177/0363546519837516DOI Listing
April 2019
2 Reads

Pain Management Associated with Total Joint Arthroplasty: A Primer.

Perm J 2019 ;23

Lenox Hill Hospital, Northwell Health, New York, NY.

This primer presents a synopsis of pain management strategies associated with total joint arthroplasty. Patients considering total joint arthroplasty often experience moderate to severe pain, which places them at risk of opioid abuse or addiction. Currently, the best practice strategies involve the development of individualized multimodal perioperative approaches to pain management. Read More

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http://www.thepermanentejournal.org/issues/2019/spring/7019-
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http://dx.doi.org/10.7812/TPP/18-169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443359PMC
January 2019
3 Reads

Treatment-resistant depression as risk factor for substance use disorders-a nation-wide register-based cohort study.

Addiction 2019 Apr 1. Epub 2019 Apr 1.

Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Background And Aims: Treatment-resistant depression (TRD) is common among patients with major depressive disorder (MDD). MDD may increase the risk for developing substance use disorders (SUD). The aim of this study was to investigate the risk for developing SUD among patients with TRD compared with other depressed patients. Read More

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http://dx.doi.org/10.1111/add.14596DOI Listing
April 2019
5 Reads

Morpheus and the Underworld-Interventions to Reduce the Risks of Opioid Use After Surgery: ORADEs, Dependence, Cancer Progression, and Anastomotic Leakage.

J Gastrointest Surg 2019 Apr 1. Epub 2019 Apr 1.

Department of Upper Gastrointestinal Surgery, Liverpool Hospital, Suite 6, Level 2, 171 Bigge St, Liverpool, Sydney, NSW, 2170, Australia.

Background: Perioperative pain management is a key element of enhanced recovery after surgery (ERAS) programs. A multimodal approach to analgesia as part of a coordinated ERAS includes the reduction of opioid use. This review aims to discuss opioid-related adverse events, strategies to reduce opioid use after surgery, and the relevance to the present "opioid crisis" in North America. Read More

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http://link.springer.com/10.1007/s11605-019-04167-3
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http://dx.doi.org/10.1007/s11605-019-04167-3DOI Listing
April 2019
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Opioid Prescribing in an Opioid Crisis: What Basic Skills Should an Oncologist Have Regarding Opioid Therapy?

Curr Treat Options Oncol 2019 Apr 1;20(5):39. Epub 2019 Apr 1.

Department of Palliative, Rehabilitation, & Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

Opinion Statement: Although clinical evidence supports the use of opioids for cancer-related pain, doing so amidst the current opioid crisis remains a challenge. A proportion of opioid-related deaths in the USA are attributable to prescription opioids, which implicates health care providers as one of the major contributors. It is therefore even more important now for all clinicians to follow safe and effective opioid prescribing practices. Read More

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http://dx.doi.org/10.1007/s11864-019-0636-3DOI Listing
April 2019
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The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits.

Neurobiol Stress 2019 Feb 27;10:100145. Epub 2018 Dec 27.

Department of Neurology, Miller School of Medicine, University of Miami, Miami, USA.

Prenatal substance exposure is a growing public health concern worldwide. Although the opioid crisis remains one of the most prevalent addiction problems in our society, abuse of cocaine, methamphetamines, and other illicit drugs, particularly amongst pregnant women, are nonetheless significant and widespread. Evidence demonstrates prenatal drug exposure can affect fetal brain development and thus can have long-lasting impact on neurobehavioral and cognitive performance later in life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23522895183001
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http://dx.doi.org/10.1016/j.ynstr.2018.100145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430408PMC
February 2019
2 Reads

Perception of prescription drug monitoring programs as a prevention tool in primary medical care.

Res Social Adm Pharm 2019 Mar 26. Epub 2019 Mar 26.

University of Florida, College of Medicine, Department of Obstetrics and Gynecology, Gainesville, FL, USA.

Background: Prescription drug monitoring programs (PDMPs) are primary prevention tools to reduce substance use disorders (SUD) and sequelae. Evidence regarding perceptions of PDMPs from different primary care providers, which may impact PDMP utilization for women, is unavailable.

Objective: To examine perceived PDMP effectiveness among obstetrician-gynecologists (OB/GYNs) compared to primary care physicians (PCPs). Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.03.012DOI Listing
March 2019
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Opioid Abuse Prevention and Treatment: Lessons From South Carolina.

J Public Health Manag Pract 2019 May/Jun;25(3):221-228

College of Global Public Health, New York University, New York, New York (Mr Arnold and Mss Bloch and Holzman); Department of Population Health at NYU Langone School of Medicine, New York, New York (Mr Arshonsky); and Institute of Human Values in Health Care, Medical University of South Carolina, Charleston, South Carolina (Dr Sade).

Context: Opioid-related overdoses in the United States have increased by 33% over the past 5 years. America's opioid crisis is increasing across demographic groups and spreading geographically. South Carolina is one of the states in the southern region of the United States that experiences an unusually high rate of opioid-related deaths. Read More

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http://dx.doi.org/10.1097/PHH.0000000000000894DOI Listing
April 2019
15 Reads