213,102 results match your criteria Ophthalmology Management[Journal]


OCT-Angiography as a Help in the Diagnosis of a Laser Pointer Retinal Injury: A Case Report.

Klin Monbl Augenheilkd 2019 Feb 20. Epub 2019 Feb 20.

Ophthalmology, RétinElysée, Lausanne, Switzerland.

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http://dx.doi.org/10.1055/a-0828-7449DOI Listing
February 2019

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):704-711

Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States.

Purpose: While VZV DNA and antigen have been detected in acute and chronic VZV keratitis, it is unclear whether productive infection of corneal cells is ongoing or whether residual, noninfectious VZV antigens elicit inflammation. Herein, we examined VZV-infected primary human corneal epithelial cells (HCECs) and keratocytes (HKs) to elucidate the pathogenesis of VZV keratitis.

Methods: HCECs and HKs were mock- or VZV infected. Read More

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http://dx.doi.org/10.1167/iovs.18-25801DOI Listing
February 2019

Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):685-693

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects.

Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. Read More

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http://dx.doi.org/10.1167/iovs.18-25864DOI Listing
February 2019

Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):677-684

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Purpose: To investigate the effect of trabeculectomy on the waveform changes of laser speckle flowgraphy (LSFG) in the optic nerve head (ONH) in patients with glaucoma.

Methods: Forty-eight eyes of 48 patients with open angle glaucoma were included in this prospective study. LSFG was performed before and 1, 3, and 6 months after trabeculectomy. Read More

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http://dx.doi.org/10.1167/iovs.18-25694DOI Listing
February 2019

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):731-740

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

Purpose: Krüppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal transition (EMT). As KLF4 and TGF-β regulate each other in a context-dependent manner, we evaluated the role of the crosstalk between KLF4 and TGF-β-signaling in CE homeostasis. Read More

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http://dx.doi.org/10.1167/iovs.18-26423DOI Listing
February 2019

Diabetes Alters pH Control in Rat Retina.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):723-730

Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States.

Purpose: The purpose of this study was to determine whether the ability of the rat retina to control its pH is affected by diabetes.

Methods: Double-barreled H+-selective microelectrodes were used to measure extracellular [H+] in the dark-adapted retina of intact control and diabetic Long-Evans rats 1 to 6 months after intraperitoneal injection of vehicle or streptozotocin, respectively. Two manipulations-increasing of blood glucose and intravenous injection of the carbonic anhydrase blocker dorzolamide (DZM)-were used to examine their effects on retinal pH regulation. Read More

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http://dx.doi.org/10.1167/iovs.18-26073DOI Listing
February 2019

Deep Learning for Prediction of AMD Progression: A Pilot Study.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):712-722

NIHR Moorfields Biomedical Research Centre, London, United Kingdom.

Purpose: To develop and assess a method for predicting the likelihood of converting from early/intermediate to advanced wet age-related macular degeneration (AMD) using optical coherence tomography (OCT) imaging and methods of deep learning.

Methods: Seventy-one eyes of 71 patients with confirmed early/intermediate AMD with contralateral wet AMD were imaged with OCT three times over 2 years (baseline, year 1, year 2). These eyes were divided into two groups: eyes that had not converted to wet AMD (n = 40) at year 2 and those that had (n = 31). Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-25325DOI Listing
February 2019
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Hemodynamic Response of the Three Macular Capillary Plexuses in Dark Adaptation and Flicker Stimulation Using Optical Coherence Tomography Angiography.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):694-703

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.

Purpose: To assess retinal microvascular reactivity during dark adaptation and the transition to ambient light and after flicker stimulation using optical coherence tomography angiography (OCTA).

Methods: Fifteen eyes of 15 healthy participants were dark adapted for 45 minutes followed by OCTA imaging in the dark-adapted state. After 5 minutes of normal lighting, subjects underwent OCTA imaging. Read More

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http://dx.doi.org/10.1167/iovs.18-25478DOI Listing
February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):650-660

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: DNA methylation is a key epigenetic modification involved in various biological processes and diseases. Corneal epithelial wound healing (CEWH) is essential for restoring corneal integrity and transparency after injury. However, the role of DNA methylation in CEWH remains elusive. Read More

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http://dx.doi.org/10.1167/iovs.18-25443DOI Listing
February 2019

Surgical management of intraocular lens dislocation: A meta-analysis.

PLoS One 2019 20;14(2):e0211489. Epub 2019 Feb 20.

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Purpose: To compare the efficacy and safety of intraocular lens (IOL) repositioning and IOL exchange for the treatment of patients with IOL dislocation.

Methods: We systematically searched for relevant publications in English or Chinese in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, China Biology Medicine Database, China National Knowledge Infrastructure Database and grey literature sources. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211489PLOS
February 2019

Eyes on New Product Development.

Authors:
Gary D Novack

J Ocul Pharmacol Ther 2019 Feb 20. Epub 2019 Feb 20.

1 PharmaLogic Development, Inc., San Rafael, California.

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http://dx.doi.org/10.1089/jop.2018.29052.gdnDOI Listing
February 2019

PP2A: A Novel Target to Prevent Cathepsin S-Mediated Damage in Smoking-Induced COPD.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

University of Southern California, 5116, Ophthalmology, Los Angeles, California, United States ;

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http://dx.doi.org/10.1164/rccm.201901-0219EDDOI Listing
February 2019

Schnyder corneal dystrophy-associated UBIAD1 Inhibits ER-associated degradation of HMG CoA reductase in mice.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States.

Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K. Using cultured cells, we previously showed that sterols trigger binding of UBIAD1 to the cholesterol biosynthetic enzyme HMG CoA reductase (HMGCR), thereby inhibiting its endoplasmic reticulum (ER)-associated degradation (ERAD) (Schumacher et al. Read More

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http://dx.doi.org/10.7554/eLife.44396DOI Listing
February 2019

Recent Advances in Carbon-Based Metal-Free Electrocatalysts.

Adv Mater 2019 Feb 20:e1806403. Epub 2019 Feb 20.

Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.

Precious noble metals (such as Pt, Ir) and nonprecious transition metals (e.g., Fe, Co), including their compounds (e. Read More

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http://dx.doi.org/10.1002/adma.201806403DOI Listing
February 2019

Identification of atheroprone shear stress responsive regulatory elements in endothelial cells.

Cardiovasc Res 2019 Feb 20. Epub 2019 Feb 20.

Institute of Anatomy and Vascular Biology, Westfälische Wilhelms-Universität Münster, Vesaliusweg 2-4, 48149 Münster, Germany.

Aim: Oscillatory shear stress (OSS) is an atheroprone hemodynamic force that occurs in areas of vessel irregularities and is implicated in the pathogenesis of atherosclerosis. Changes in signaling and transcriptional program in response to OSS have been vigorously studied, however, the underlying changes in the chromatin landscape controlling transcription remain to be elucidated. Here, we investigated the changes in the regulatory element (RE) landscape of endothelial cells under atheroprone OSS conditions in an in vitro model. Read More

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http://dx.doi.org/10.1093/cvr/cvz027DOI Listing
February 2019
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Safety profile of baricitinib in Japanese patients with active rheumatoid arthritis with over 1.6 years median time in treatment: an integrated analysis of Phase 2 and 3 trials.

Mod Rheumatol 2019 Feb 20:1-23. Epub 2019 Feb 20.

g First Department of Internal Medicine , School of Medicine, University of Occupational and Environmental Health , Kitakyushu , Japan.

Objectives: Baricitinib is a selective oral inhibitor of JAK1/JAK2 for patients with moderately-to-severely active rheumatoid arthritis (RA). Baricitinib's safety profile in Japanese patients was evaluated using 6 studies (5 Ph2/Ph3 trials, 1 long-term extension study thru 01-Sept-2016) from an integrated database (9 RA studies).

Methods: Incidence rates (IRs) or exposure-adjusted IRs (EAIRs) of adverse events (AEs) per 100 patient-years (PY) were calculated using data which included RA patients exposed to any baricitinib dose. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583711DOI Listing
February 2019

Novel contribution of epigenetic changes to nuclear dynamics.

Nucleus 2019 Feb 20. Epub 2019 Feb 20.

b Department of Immunology Ophthalmology and ENT, Hospital 12 de Octubre Health Research Institute (imas12) , Complutense University, School of Medicine , Madrid , Spain .

Migrating cells have to cross many physical barriers and confined spaces during their movement in 3D environments. The surrounding environment promotes mechano- and biological signals that orchestrate cellular changes, such as cytoskeletal and adhesion rearrangements and proteolytic digestion. Many recent studies provide new insights into how the nucleus must alter its shape, localization and mechanical properties in order to promote nuclear deformability, chromatin compaction and gene reprogramming. Read More

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http://dx.doi.org/10.1080/19491034.2019.1580100DOI Listing
February 2019

KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.

Long noncoding RNAs have been reported to play important roles in the pathogenesis of diabetic retinopathy (DR), which has been considered as the most common disease leading to vision loss. However, it is still unclear whether KCNQ1 overlapping transcript 1 (KCNQ1OT1) could affect DR. In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells. Read More

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http://dx.doi.org/10.1002/jcp.28344DOI Listing
February 2019

SubILM Injection of AAV for Gene Delivery to the Retina.

Methods Mol Biol 2019 ;1950:249-262

Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA.

Adeno-associated virus (AAV) has emerged as the vector of choice for delivering genes to the retina. Indeed, the first gene therapy to receive FDA approval in the United States is an AAV-based treatment for the inherited retinal disease, Leber congenital amaurosis-2. Voretigene neparvovec (Luxturna™) is delivered to patients via subretinal (SR) injection, an invasive surgical procedure that requires detachment of photoreceptors (PRs) from the retinal pigment epithelium (RPE). Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_14DOI Listing
January 2019

Quantitative and Digital Droplet-Based AAV Genome Titration.

Methods Mol Biol 2019 ;1950:51-83

Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

The adeno-associated viral vector (AAV) platform has developed into a primary modality for efficient in vivo, and in more limited settings, in vitro or ex vivo gene transfer. Its applications range from a tool for experimental purposes to preclinical and clinical gene therapy. The ability to accurately and reproducibly quantify vector concentration is critical for any of these applications. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_4DOI Listing
January 2019

Macular spectral-domain optical coherence tomography values and correlations in healthy children.

Int Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Università di Pisa-Dipartimento di patologia chirurgica medica, molecolare e dell'area critica, Via Savi n. 10, 56126, Pisa, PI, Italy.

Purpose: The aim of this study is to investigate potential correlations between age, gender, spherical equivalent and optical coherence tomography (OCT) retinal parameters among healthy children.

Methods: A macular spectral-domain OCT was performed in all patients using a Spectralis OCT device, and the macular thickness and volume of each of the early treatment diabetic retinopathy study (ETDRS) subfields were analysed.

Results: Ninety-four children were enrolled. Read More

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http://dx.doi.org/10.1007/s10792-019-01085-wDOI Listing
February 2019

Tear-film-oriented diagnosis for dry eye.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Optics and Spectroscopy, Faculty of Physics, St. Kliment Ohridski University of Sofia, Sofia, Bulgaria.

Tear-film (TF) stability protects the ocular surface epithelium from desiccation and is ensured via cooperation between the ocular surface components including constituents of the TF and ocular surface epithelium. Thus, when those components are insufficient or impaired, the TF breakup that initiates dry eye occurs. Recently, new, commercially available eye drops have appeared in Japan that enable TF stabilization via targeted supplementation of deficient ocular surface components. Read More

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http://dx.doi.org/10.1007/s10384-018-00645-4DOI Listing
February 2019

Three-dimensional analysis of morphologic changes and visual outcomes in diabetic macular edema.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, Republic of Korea.

Purpose: To investigate the association of retinal fluid volume with the visual and anatomic outcomes of patients with diabetic macular edema (DME) after treatment with bevacizumab.

Study Design: Retrospective observational study.

Methods: We retrospectively analyzed 65 eyes of 58 DME patients treated with bevacizumab. Read More

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http://dx.doi.org/10.1007/s10384-019-00657-8DOI Listing
February 2019

Treatment of macular hemorrhage in retinal arterial microaneurysm: anatomic site-oriented therapy.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To investigate the usefulness of anatomic site-oriented therapy for macular hemorrhage secondary to retinal arterial macroaneurysm (RAM).

Study Design: Retrospective observational study, clinical case series METHODS: Twenty-seven consecutive patients (27 eyes) with macular hemorrhage secondary to RAM were classified according to the retinal layer(s) with hemorrhage identified by optical coherence tomography into 4 types and treated differentially. Vitrectomy was conducted for subinternal limiting membrane hemorrhage (SILMH), intravitreal gas injection for subretinal hemorrhage (SRH) or intraretinal hemorrhage (IRH), and vitrectomy and intravitreal air/gas exchange for multilevel hemorrhage (at least 2 among SILMH/SRH/IRH). Read More

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http://dx.doi.org/10.1007/s10384-019-00653-yDOI Listing
February 2019

Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.

Purpose: To examine the effects of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy (BK).

Study Design: Retrospective case series METHODS: Consecutive patients with BK who did not wish to receive corneal transplantation and were treated with 0.1% betamethasone eyedrops were included. Read More

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http://dx.doi.org/10.1007/s10384-019-00658-7DOI Listing
February 2019

Descemet stripping automated endothelial keratoplasty performed by trainees.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-8513, Japan.

Purpose: To assess the surgical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed by trainees.

Study Design: Retrospective, case control comparative study.

Methods: This study compared cases performed by trainees with those performed by an experienced surgeon. Read More

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http://dx.doi.org/10.1007/s10384-019-00652-zDOI Listing
February 2019

Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Department of Ophthalmology, Hospital Universitario Príncipe de Asturias, Carretera Alcalá-Meco s/n, Alcalá de Henares, 28805, Madrid, Spain.

Purpose: The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls.

Methods: A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). Read More

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http://dx.doi.org/10.1007/s00417-019-04272-8DOI Listing
February 2019

Choroidal neovascularization imaging using multiple en face optical coherence tomography angiography image averaging.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Purpose: To determine the effects of averaging five en face optical coherence tomography angiographic (OCTA) images on the quality of the images in eyes with a choroidal neovascularization (CNV).

Methods: Twenty-seven eyes of 25 patients (18 men, 7 women; average age 71.0 years) with a CNV were examined by OCTA (OCT HS-100, Canon. Read More

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http://dx.doi.org/10.1007/s00417-019-04275-5DOI Listing
February 2019

An investigation of the ocular toxic effects of levetiracetam therapy in children with epilepsy.

Childs Nerv Syst 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Medicine, Department of Child Neurology, Karadeniz Technical University, Trabzon, Turkey.

Objective: To investigate the potential toxic effects of levetiracetam monotherapy on ocular tissues in cases of pediatric epilepsy using optical coherence tomography (OCT).

Methods: Thirty epileptic children (group 1) receiving levetiracetam monotherapy at a dosage of 20-40 mg/kg/day for at least 1 year with a first diagnosis of epilepsy and 30 age- and gender-matched healthy children (group 2) were included in the study. In addition to a detailed eye examination, peripapillary retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal thickness (FT), and central corneal thickness (CCT) were measured in all children by means of spectral domain OCT. Read More

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http://dx.doi.org/10.1007/s00381-019-04076-5DOI Listing
February 2019

[Future through history].

Authors:
J M Rohrbach

Ophthalmologe 2019 Feb 19. Epub 2019 Feb 19.

Augenklinik, Universitäts-Klinikum Tübingen, Elfriede-Aulhorn-Str. 7, 72076, Tübingen, Deutschland.

The motto of the German Ophthalmolological Society (DOG) Congress 2019 "Ophthalmology: our medical discipline with a future" raises the question of what "ophthalmological future" should really be, what are its driving forces and what are the foundations of its design. The design of the future, usually equated with "progress", naturally always takes place out of the present, which itself is a product of the past. History, like time and evolution, is always a continuum. Read More

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http://dx.doi.org/10.1007/s00347-019-0862-xDOI Listing
February 2019

[Astigmatism].

Ophthalmologe 2019 Feb 19. Epub 2019 Feb 19.

Univ.-Augenklinik Düsseldorf, Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Astigmatism is the most frequent refractive error worldwide followed by hyperopia and myopia. Internal astigmatism has to be differentiated from external astigmatism. Furthermore, external astigmatism can be divided into "with the rule", "against the rule" and "oblique". Read More

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http://dx.doi.org/10.1007/s00347-019-0865-7DOI Listing
February 2019

Consensus statement on abusive head trauma: additional endorsements.

Pediatr Radiol 2019 Mar 19;49(3):421. Epub 2019 Feb 19.

UMR 7268 ADÉS, Aix-Marseille Université-EFS-CNRS, Marseille, France.

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http://dx.doi.org/10.1007/s00247-019-04342-3DOI Listing

Modes of Accessing Bicarbonate for the Regulation of Membrane Guanylate Cyclase (ROS-GC) in Retinal Rods and Cones.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 15.

Research Divisions of Biochemistry and Molecular Biology, Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA 19027.

The membrane guanylate cyclase, ROS-GC, that synthesizes cyclic GMP for use as a second messenger for visual transduction in retinal rods and cones, is stimulated by bicarbonate. Bicarbonate acts directly on ROS-GC1, because it enhanced the enzymatic activity of a purified, recombinant fragment of bovine ROS-GC1 consisting solely of the core catalytic domain. Moreover, recombinant ROS-GC1 proved to be a true sensor of bicarbonate, rather than a sensor for CO. Read More

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http://dx.doi.org/10.1523/ENEURO.0393-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378327PMC
February 2019

Interocular Symmetry of Fixation, Optic Disc, and Corneal Astigmatism in Bilateral High Myopia: The Shanghai High Myopia Study.

Transl Vis Sci Technol 2019 Jan 13;8(1):22. Epub 2019 Feb 13.

Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People's Republic of China.

Purpose: We investigate the interocular symmetry of fixation, optic disc, and corneal astigmatism in bilateral high myopia, and evaluate the predictive relationships between them.

Methods: We enrolled 202 cases with bilateral high myopia. Fixation, in terms of the bivariate contour ellipse area (BCEA), was evaluated with the Macular Integrity Assessment microperimetry. Read More

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http://dx.doi.org/10.1167/tvst.8.1.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375117PMC
January 2019

Intravitreal Injection of 1.25% Povidone Iodine Followed by Vitrectomy Using 0.025% Povidone Iodine Irrigation for Treating Endophthalmitis.

Transl Vis Sci Technol 2019 Jan 13;8(1):21. Epub 2019 Feb 13.

Department of Ophthalmology, Faculty of Medicine, Saitama Medical University, Iruma, Saitama, Japan.

Purpose: To investigate the safety and effectiveness of intravitreal injection (IVI) of 1.25% povidone iodine (PI) followed by vitrectomy using 0.025% PI irrigation for treating endophthalmitis. Read More

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http://dx.doi.org/10.1167/tvst.8.1.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375116PMC
January 2019
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Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study.

Exp Ther Med 2019 Mar 24;17(3):1891-1895. Epub 2018 Dec 24.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

The aim of the present study was to investigate the utility of diffusion tensor imaging (DTI) parameters of the central visual pathway and the size of the lateral geniculate nucleus (LGN) in the diagnosis of primary open-angle glaucoma (POAG). To test this, 24 POAG patients and 24 age- and gender-matched controls underwent 3.0 Tesla magnetic resonance imaging examinations, including DTI and LGN structural imaging. Read More

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http://dx.doi.org/10.3892/etm.2018.7134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364226PMC

Endovascular treatment of middle cerebral artery aneurysm with a (LVIS) device: Comparison of LVIS stent and non-LVIS stent.

Exp Ther Med 2019 Mar 28;17(3):1656-1662. Epub 2018 Dec 28.

Department of Ophthalmology and Otorhinolaryngology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315040, P.R. China.

Middle cerebral artery (MCA) aneurysm is a serious medical condition mainly occurring in the proximal and bifurcation tracts. Evidence has indicated that endovascular treatment is an effective surgical method for patients with MCA aneurysm. In the present study, the efficacy of endovascular treatment with low-profile visualized intraluminal support (LVIS) stent for MCA aneurysms was evaluated in comparison with that using a non-LVIS stent device. Read More

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http://dx.doi.org/10.3892/etm.2018.7139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364188PMC

Oral fluoxetine in the management of amblyopic patients aged between 10 and 40 years old: a randomized clinical trial.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Poostchi Ophthalmology Research Center, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: The objective of this study is to assess the efficacy of oral fluoxetine therapy in improving the visual function of amblyopic patients aged between 10 and 40 years old.

Methods: In this double-blinded, randomized, controlled trial (IRCT2016052428046N1; registered retrospectively), 40 eligible participants with anisometropic or mixed amblyopia were randomly assigned to either fluoxetine or placebo groups. Participants with anisometropia and logMAR best spectacle-corrected visual acuity (BSCVA) worse than 0. Read More

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http://dx.doi.org/10.1038/s41433-019-0360-zDOI Listing
February 2019

Differing presenting features of idiopathic intracranial hypertension in the UK and US.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Aim: Demographic factors potentially influencing the presentation and severity of idiopathic intracranial hypertension (IIH) in the US vs. UK populations include obesity and ethnicity. We aimed to compare the presenting features of IIH between populations in the UK and US tertiary referral centres, to assess what population differences exist and whether these cause different presentations and impact on visual function. Read More

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http://dx.doi.org/10.1038/s41433-019-0359-5DOI Listing
February 2019

The effect of reduced contrast sensitivity on colour vision testing.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To assess the effect of reduced contrast sensitivity on three commonly used colour vision tests in order to establish key discrepancies that may be relevant for clinical practice.

Methods: A prospective non-interventional clinical study of colour vision testing using three commonly used devices: Ishihara and Hardy-Rand-Rittler (H-R-R) pseudoisocochromatic plate tests, and Farnsworth D-15 arrangement test performed under progressively reduced contrast sensitivity conditions achieved with a neutral density filter bar.

Results: The Pelli-Robson contrast sensitivity (PRCS) at which 5% of the population should first experience a 10% reduction in colour vision testing from baseline was calculated for each of the three colour vision devices: Farnsworth D-15 test: 1. Read More

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http://dx.doi.org/10.1038/s41433-019-0361-yDOI Listing
February 2019

Transcanalicular endoscopic primary dacryoplasty for congenital nasolacrimal duct obstruction.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology and Micro-technology, Yokohama City University Medical Center, Yokohama City, Japan.

Objectives: To examine the causes of congenital nasolacrimal duct obstruction (CNLDO) using dacryoendoscopy, and to evaluate the surgical outcomes of primary transcanalicular endoscopic dacryoplasty.

Methods: The subjects of this study were a total of 56 eyes of 46 Japanese children aged one to five years old (mean, 29.1 ± 14. Read More

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http://dx.doi.org/10.1038/s41433-019-0374-6DOI Listing
February 2019

Management of the photic sneeze reflex utilising the philtral pressure technique.

Eye (Lond) 2019 Feb 19. Epub 2019 Feb 19.

University of New South Wales, Kensington, Sydney, Australia.

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http://dx.doi.org/10.1038/s41433-019-0368-4DOI Listing
February 2019

Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation by inhibiting Th17-associated pro-inflammatory gene expression.

Sci Rep 2019 Feb 19;9(1):2301. Epub 2019 Feb 19.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Autoimmune uveitis is a sight-threatening disease mainly caused by dysregulation of immunity. We investigated the therapeutic effects of green tea extract (GTE) and its major component, epigallocatechin-3-gallate (EGCG), on a murine model of experimental autoimmune uveoretinitis (EAU). Oral administration of GTE, EGCG, dexamethasone, or water, which started 5 days before the induction, was fed every two days to each group. Read More

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http://dx.doi.org/10.1038/s41598-019-38868-1DOI Listing
February 2019

Anoctamin-4 is a bona fide Ca-dependent non-selective cation channel.

Sci Rep 2019 Feb 19;9(1):2257. Epub 2019 Feb 19.

Experimental Ophthalmology, Department of Ophthalmology, Charité - Universitätsmedizin Berlin, a corporate member of Freie Universität, Humboldt-University, the Berlin Institute of Health, Berlin, Germany.

Changes in cell function occur by specific patterns of intracellular Ca, activating Ca-sensitive proteins. The anoctamin (TMEM16) protein family has Ca-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so far unknown Ano4 function as Ca-dependent, non-selective monovalent cation channel; heterologous Ano4 expression in HEK293 cells elicits Ca activated conductance with weak selectivity of K > Na > Li. Read More

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http://dx.doi.org/10.1038/s41598-018-37287-yDOI Listing
February 2019

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Sci Rep 2019 Feb 19;9(1):2314. Epub 2019 Feb 19.

Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Irreversible photoreceptor cell death is a major cause of blindness in many retinal dystrophies. A better understanding of the molecular mechanisms underlying the progressive loss of photoreceptor cells remains therefore crucial. Abnormal expression of microRNAs (miRNAs) has been linked with the aetiology of a number of retinal dystrophies. Read More

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http://dx.doi.org/10.1038/s41598-018-38294-9DOI Listing
February 2019

Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters.

Ophthalmic Res 2019 Feb 15:1-10. Epub 2019 Feb 15.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou,

Purpose: To measure lamina cribrosa thickness (LCT) and anterior lamina cribrosa surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic primary angle-closure glaucoma (CPACG), and control patients using spectral-domain optical coherence tomography (SD-OCT) and examine its association with relevant ocular parameters.

Methods: In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG patients (65 eyes), and 55 CPACG patients (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way of enhanced depth imaging using Heidelberg SD-OCT. The obtained LCT and ALCSD were compared among the control, POAG, and CPACG groups. Read More

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http://dx.doi.org/10.1159/000496558DOI Listing
February 2019

Prevalence of amblyopia and strabismus in Hani school children in rural southwest China: a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e025441. Epub 2019 Feb 19.

Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Purpose: To determine the prevalence rate of amblyopia and strabismus in Chinese Hani ethnic school-aged children.

Methods: All grade 1 and grade 7 students in Mojiang Hani Autonomous County, located in southwest China, were invited for comprehensive eye examinations performed by experienced ophthalmologists and optometrists, including visual acuity, ocular alignment and movements, cycloplegic autorefraction, anterior segment and fundus examinations. Standard definitions of amblyopia and strabismus were applied to calculate their prevalence rate. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025441DOI Listing
February 2019

Dietary intervention in patients with age-related macular degeneration: protocol for a randomised controlled trial.

BMJ Open 2019 Feb 19;9(2):e024774. Epub 2019 Feb 19.

Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.

Introduction: Age-related macular degeneration (AMD) is a leading cause of blindness. After smoking, nutrition is the key modifiable factor in reducing AMD incidence and progression, and no other preventative treatments are currently available. At present, there is an evidence-practice gap of dietary recommendations made by eye care practitioners and those actually practised by patients with AMD. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024774DOI Listing
February 2019

Identification of barriers, facilitators and system-based implementation strategies to increase teleophthalmology use for diabetic eye screening in a rural US primary care clinic: a qualitative study.

BMJ Open 2019 Feb 18;9(2):e022594. Epub 2019 Feb 18.

Health Innovation Program, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

Objective: Teleophthalmology for diabetic eye screening is an evidence-based intervention substantially underused in US multipayer primary care clinics, even when equipment and trained personnel are readily available. We sought to identify patient and primary care provider (PCP) barriers, facilitators, as well as strategies to increase teleophthalmology use.

Design: We conducted standardised open-ended, individual interviews and analysed the transcripts using both inductive and directed content analysis to identify barriers and facilitators to teleophthalmology use. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02259
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http://dx.doi.org/10.1136/bmjopen-2018-022594DOI Listing
February 2019
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