216,004 results match your criteria Ophthalmology Management[Journal]


Medical and surgical management of conjunctivochalasis.

Ocul Surf 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address:

Conjunctivochalasis (CCH) is a bilateral conjunctival condition characterized by loose, redundant conjunctival folds, typically in the inferior bulbar conjunctiva. It is a common cause of ocular irritation, especially in older age. For asymptomatic CCH, no treatment is necessary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15420124183045
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http://dx.doi.org/10.1016/j.jtos.2019.04.008DOI Listing
April 2019
6 Reads

Subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelium (MA09-hRPE): A safety and tolerability evaluation in minipigs.

Regul Toxicol Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, Republic of Korea; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, Republic of Korea. Electronic address:

This study aimed to determine the safety and tolerability of the subretinal injection of hESC-derived RPE cells at higher doses than the established clinical dose (5 × 10 cells/150 μL) by using minipigs. The hESC-derived RPE cells (60 or 120 × 10 cells/150 μL) were injected in subretinal region, and minipigs were sacrificed at Weeks 4, 8, and 12 post-surgery. Time-course examination was performed by using fundus photography, optical coherence tomography (OCT), histopathology, and fluorescence in situ hybridization (FISH). Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.04.006DOI Listing

Diabetic retinopathy: Focus on NADPH oxidase and its potential as therapeutic target.

Eur J Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address:

Diabetic retinopathy is a common complication of diabetes that affects the retina due to a sustained high blood sugar level. Recent studies have demonstrated that high glucose-driven oxidative stress plays an important role in the microvascular complications of retina in diabetes. Oxidative stress occurs due to the excess of reactive oxygen species, which causes oxidative damage to retina, leading to the leak of tiny blood vessels, or acts as signaling molecules to trigger neovascularization, resulting in new fragile vessels. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.038DOI Listing

It's Not Your Eyes.

Surv Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Departments of Neurology, Ophthalmology, Neurosurgery, Otolaryngology - Head & Neck Surgery, Emergency Medicine The John Hopkins University School of Medicine Baltimore, Maryland.

A 55-year-old woman reported blurred vision while walking, numbness and tingling, contact allodynia, and gait imbalance. Visual acuity was 20/20 in both eyes, but there was a loss of 4 lines with horizontal dynamic visual acuity testing. Ocular motility examination demonstrated spontaneous downbeat nystagmus that increased in lateral gaze with a torsional component and impaired smooth pursuits. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.04.004DOI Listing

Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis.

Exp Eye Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA; Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

Herpes stromal keratitis (HSK) is a chronic immunoinflammatory condition which develops in response to recurrent herpes simplex virus-1 (HSV-1) infection of the cornea. Patients with HSK often demonstrate the concurrence of corneal desiccation and the loss of blink reflex. However, the relationship between severity of HSK, level of basal tears and inflammation of the lacrimal gland is mostly unexplored. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835193013
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http://dx.doi.org/10.1016/j.exer.2019.04.022DOI Listing
April 2019
1 Read

Refractive Laser-Assisted Cataract Surgery vs. Conventional Manual Surgery: Comparing Efficacy and Safety in 3144 Eyes.

Am J Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada; Uptown Eye Specialists, Vaughan, Canada. Electronic address:

Purpose: To report on outcomes of efficacy and safety in one of the largest series of eyes undergoing either conventional manual cataract surgery (MCS) or refractive femtosecond laser-assisted cataract surgery (ReLACS).

Design: Retrospective, consecutive, interventional comparative case series.

Methods: This study included 3144 consecutive eyes of which 1580 were treated via MCS and 1564 were treated via ReLACS at Uptown Surgical Centre in Vaughan, Canada. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.010DOI Listing

Changes in Retinal Microcirculation Precede the Clinical Onset of Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus.

Am J Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Endocrinology, Dr. Sami Ulus Children's Health and Disease Training and Research Hospital, Ankara, Turkey.

Purpose: To investigate whether abnormal glucose metabolism in diabetes mellitus (DM) affects the retinal microcirculation of children with well-controlled type 1 DM and to compare these results with those obtained from healthy children.

Design: Cross-sectional prospective study.

Methods: This study enrolled 60 patients with DM without clinically detectable diabetic retinopathy (DR) and who met 57 age-matched controls. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.011DOI Listing

Recent advances in gelatin-based therapeutics.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

a NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7 , Vitoria-Gasteiz 01006 , Spain .

Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. Areas covered: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. Read More

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http://dx.doi.org/10.1080/14712598.2019.1610383DOI Listing

Serum Vitamin D Levels in Patients with Keratoconus.

Ocul Immunol Inflamm 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Ophthalmology , Kayseri Training and Research Hospital , Kayseri , Turkey.

Purpose: To evaluate serum 25-hydroxyvitamin D levels in patients with keratoconus (KC) and its association with disease severity and to compare vitamin D levels with those of age- and sex-matched healthy individuals.

Methods: This study included 100 patients with KC and 100 non-atopic healthy controls. Serum vitamin D levels were measured using liquid chromatography-tandem mass spectrometry and compared between the study groups. Read More

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http://dx.doi.org/10.1080/09273948.2019.1604002DOI Listing

Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1696-1705

Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States.

Purpose: The goal of this work was to design and assess the ability of unmodified and surface-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to enhance cell association, provide efficacy in retinoblastoma cells, and overcome current administration challenges, including hydrolysis and precipitation, of intravitreal administration.

Methods: A single emulsion method was used to encapsulate Coumarin 6, to enable NP visualization via fluorescence microscopy. Melphalan NPs were synthesized using an adapted double-emulsion method to reduce melphalan loss during fabrication. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-26251DOI Listing
April 2019
1 Read

Leber Congenital Amaurosis (LCA): Potential for Improvement of Vision.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1680-1695

Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.19-26672DOI Listing
April 2019
1 Read

Introducing Artur V. Cideciyan and Samuel G. Jacobson, the 2018 Recipients of the Proctor Medal.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1677-1679

Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1167/iovs.19-26884DOI Listing

Development of a Pde6b Gene Knockout Rat Model for Studies of Degenerative Retinal Diseases.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1519-1526

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To describe the phenotypes of a newly developed Pde6b-deficient rat model of retinal degeneration.

Methods: Pde6b knockout rats were produced by CRISPR-Cpf1 technology. Pde6b knockout rats were evaluated for ocular abnormalities by comparison with wild-type eyes. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-25556DOI Listing
April 2019
1 Read

Prevalence, awareness and control of diabetes in Russia: The Ural Eye and Medical Study on adults aged 40+ years.

PLoS One 2019 22;14(4):e0215636. Epub 2019 Apr 22.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: Non-communicable chronic diseases have become the leading causes of mortality and disease burden worldwide. With information about the frequency of diabetes as a major non-communicable chronic disease in Russia being scarce, we assessed the prevalence of diabetes and its associated factors in a rural and urban population in Russia.

Methods: The Ural Eye and Medical Study is a population-based study in the city of Ufa/Russia and in villages in a distance of 65 km from Ufa. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215636PLOS
April 2019
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Analysis of the Corneal Anterior and Posterior Surface in Patients With Peripheral Hypertrophic Subepithelial Corneal Opacification.

Eye Contact Lens 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology (J.C.R., A.M., J.W.-P., N.P., A.G.), University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany; and Division of Biostatistics and Bioinformatics (V.W.-E.), Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Purpose: To characterize the corneal changes in peripheral hypertrophic subepithelial corneal opacification (PHSCO) considering elevation of the anterior and posterior corneal surface, corneal astigmatism, tear secretion, and endothelial cell density.

Methods: Thirty-eight eyes of 22 patients with PHSCO on at least 1 eye and 38 eyes of 22 age- and sex-matched healthy subjects were included in this retrospective cross-sectional study. Using the Pentacam system (Oculus, Wetzlar, Germany), measurement of the anterior and posterior corneal surface was performed. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000615DOI Listing
April 2019
1 Read

Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand.

Ocul Immunol Inflamm 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Ocular inflammation and infection division, Department of Ophthalmology, Phramongkutklao hospital , Phramongkutklao college of Medicine , Bangkok , Thailand.

Background: Causes of uveitis vary upon the epidemiologic, racial, and geographical variations.

Objective: The objective of the study is to analyze pattern and outcome of uveitis in Phramongkutklao Hospital.

Methods: This is a retrospective study. Read More

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http://dx.doi.org/10.1080/09273948.2019.1589527DOI Listing

Genetic variants of TSPAN12 gene in patients with retinopathy of prematurity.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, TianJin, PR China.

Genetic susceptibility to retinopathy of prematurity (ROP) has been reported. However, no virulence genes are currently known for ROP. This study aimed to assess FZD4, LRP5, TSPAN12, and NDP, which are known virulence genes involved in familial exudative vitreoretinopathy, an ailment that shares some symptoms with ROP. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28715
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http://dx.doi.org/10.1002/jcb.28715DOI Listing
April 2019
2 Reads

Homozygous stop mutation in AHR causes autosomal recessive foveal hypoplasia and infantile nystagmus.

Brain 2019 Apr 22. Epub 2019 Apr 22.

Molecular Genetics Laboratory, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.

Herein we present a consanguineous family with three children affected by foveal hypoplasia with infantile nystagmus, following an autosomal recessive mode of inheritance. The patients showed normal electroretinography responses, no signs of albinism, and no anterior segment or brain abnormalities. Upon whole exome sequencing, we identified a homozygous mutation (c. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awz098DOI Listing
April 2019
1 Read

Clinical course and risk factors of recurrent corneal erosion: Observational study.

Medicine (Baltimore) 2019 Apr;98(16):e14964

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605.

Recurrent corneal erosion (RCE) is a common disorder causing ocular pain, tearing, photophobia, and visual impairments. Various factors such as ocular trauma, ocular surgery, corneal dystrophy, contact lens wear, and diabetes mellitus (DM) can cause RCE. The purpose of this study was to determine the causative factors and clinical course of RCE. Read More

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http://dx.doi.org/10.1097/MD.0000000000014964DOI Listing

Congenital Cranial Dysinnervation Disorder: An Unusual Phenotype With Multiple Cranial Neuropathies and Novel Neuroimaging Findings.

J Neuroophthalmol 2019 Apr 16. Epub 2019 Apr 16.

Section of Pediatric Neurology (MSS, SEM), Children's Hospital; Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Section of Pediatric Ophthalmology (CM), Children's Hospital; Department of Ophthalmology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Section of Pediatric Radiology (JW), Children's Hospital; Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Congenital cranial dysinnervation disorders result from a maldevelopment of brainstem nuclei and/or cranial nerves. In some cases, specific genetic abnormalities have been identified. We expand the clinical phenotype of these disorders with the report of a 28-month-old girl who was initially evaluated for seizures and was found to have right sixth nerve palsy, small optic discs with reduced vision in her right eye. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000762DOI Listing

Outcomes of Descemet-Stripping Automated Endothelial Keratoplasty in Congenital Hereditary Endothelial Dystrophy.

Eye Contact Lens 2019 Apr 15. Epub 2019 Apr 15.

Eye Research Center (M.M., A.N., K.F.), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; and Noor Ophthalmology Research Center (H.H.), Noor Eye Hospital, Tehran, Iran.

Objectives: To evaluate the outcomes and complications of Descemet-stripping automated endothelial keratoplasty (DSAEK) in children with congenital hereditary endothelial dystrophy (CHED).

Methods: Eighteen eyes from 10 children with CHED who underwent standard phakic DSAEK were enrolled in this retrospective interventional case series. Medical records including slit-lamp biomicroscopy, cycloplegic refraction, visual acuity, and measurements of central corneal thickness, corneal topography, and endothelial cell density were evaluated. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000604DOI Listing
April 2019
1 Read

Correlation Between Anterior Corneal Elevation Differences in Main Meridians and Corneal Astigmatism.

Eye Contact Lens 2019 Apr 15. Epub 2019 Apr 15.

Department of Optics II (Optometry and Vision) (L.B., G.C.), Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain; Clínica Oftalmológica Doctor Lens (L.B.), Madrid, Spain; Department of Optics, Pharmacology and Anatomy (D.P.), University of Alicante, Alicante, Spain; and Department of Ophthalmology (Oftalmar) (D.P.), Vithas Medimar International Hospital, Alicante, Spain.

Purpose: To assess the correlation between anterior corneal elevation (ACE) and anterior corneal astigmatism (ACA) obtained with two different topographers in healthy subjects at different corneal diameters.

Methods: A retrospective, comparative, and observational study was conducted. Topography data from 305 patients obtained with the Oculus Pentacam (Oculus, Wetzlar, Germany) and Sirius (CSO, Florence, Italy) systems were collected. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000613DOI Listing

Self-induced lens subluxation with avulsion of ciliary processes in Tourette Syndrome.

Am J Ophthalmol Case Rep 2019 Jun 1;14:95-97. Epub 2019 Apr 1.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, 555 University Avenue, University of Toronto, Toronto, Ontario, Canada.

Purpose: To report a case of self-induced eye injury resulting in lens subluxation combined with avulsion of ciliary processes in a patient with Tourette Syndrome.

Observation: A 14-year-old male had repeated involuntary trauma to the left side of his face. On exam, left eye lens subluxation combined with ciliary process avulsion were noted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183057
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http://dx.doi.org/10.1016/j.ajoc.2019.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454124PMC
June 2019
1 Read

Adaptive Optics (rtx1) High-Resolution Imaging of Photoreceptors and Retinal Arteries in Patients with Diabetic Retinopathy.

J Diabetes Res 2019 17;2019:9548324. Epub 2019 Mar 17.

Medical University of Warsaw, Department of Ophthalmology, Warsaw, Poland.

Background: Diabetic retinopathy (DR) is the leading cause of impaired vision in patients with diabetes mellitus. An adaptive optics retinal camera (rtx1™; Imagine Eyes, France) was used to capture images of cones and retinal arteries from patients with DR.

Objective: Cone parameters (density, interphotoreceptor distance, and regularity) and retinal artery parameters (wall thickness, lumen diameter, WLR, and WCSA) were analyzed in 36 patients with nonproliferative DR (NPDR; 22 with mild NPDR and 14 with moderate NPDR) and in 20 healthy volunteers (the control group). Read More

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http://dx.doi.org/10.1155/2019/9548324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441527PMC

The assessment of the quality of randomized controlled trials published in Indian medical journals.

Perspect Clin Res 2019 Apr-Jun;10(2):79-83

Department of Clinical Pharmacology, SRM MCH and RC, Kattankulathur, Kancheepuram, Chennai, Tamil Nadu, India.

Aim: In this retrospective cross-sectional study, we sought to evaluate if the published randomized controlled trials (RCTs) reported in the year 2017 among the Indian medical journals (IMJs) complied with the Consolidated Standards of Reporting Trials (CONSORT) guidelines and identify domains where reporting could be improved.

Methods: A literature search was performed using PubMed and Google Scholar to identify all the IMJs that published RCTs in the year 2017. In the archives of the identified journals, the number of published RCTs was identified and the full text was obtained. Read More

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http://dx.doi.org/10.4103/picr.PICR_60_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463507PMC

Orbital Rosai-Dorfman Disease: A Case Report and Literature Review.

J Microsc Ultrastruct 2019 Jan-Mar;7(1):50-52

Department of Pathology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.

A 53-year-old male presented with dropping of the right eyelid associated with decreased visual acuity for 4 months. He also complained of vertical diplopia especially when looking down. Ophthalmological examination revealed right blepharospasm associated with right hypertropia. Read More

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http://www.jmau.org/text.asp?2019/7/1/50/254065
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http://dx.doi.org/10.4103/JMAU.JMAU_45_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442326PMC
April 2019
1 Read

Clinical Profile and Visual Outcomes of Ocular Syphilis: A Five-year Review in Hospital Universiti Sains, Malaysia.

Cureus 2019 Feb 5;11(2):e4015. Epub 2019 Feb 5.

Ophthalmology, Universiti Sains Malaysia, Kota Bharu, MYS.

Introduction Ocular syphilis is a sight-threatening condition. It can occur at any stage of syphilis infection, which present either with acute inflammation during the primary, secondary, and early latent stages or with chronic inflammation during tertiary infection, affecting virtually every ocular structure. This study was to report on the clinical presentation of ocular syphilis that presented to eye clinic Hospital Universiti Sains Malaysia. Read More

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http://dx.doi.org/10.7759/cureus.4015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453624PMC
February 2019

Characteristics and Outcomes of Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy Patients in a Limited Resource Tertiary Center over an Eight-Year Period.

J Ophthalmol 2019 17;2019:9481902. Epub 2019 Mar 17.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Thailand.

Purpose: To report characteristics and visual results in patients with PDR-associated complications following pars plana vitrectomy (PPV) in a tertiary center over an eight-year period.

Methods: Medical records of diabetic retinopathy patients receiving PPV between January 2007 and December 2014 for PDR-related complications were reviewed.

Results: A total of 890 consecutive PDR patients were included in the study. Read More

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http://dx.doi.org/10.1155/2019/9481902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441510PMC
March 2019
3 Reads

Outcome and Complications of Combined Phacoemulsification and 23-Gauge Pars Plana Vitrectomy.

J Ophthalmol 2019 17;2019:7918237. Epub 2019 Mar 17.

Cukurova University, School of Medicine, Department of Ophthalmology, Adana, Turkey.

Background: With the advances in surgical tools, simultaneous removal of cataract associated with vitreoretinal disorders is gaining popularity. This combined surgery offers several advantages besides limitations. The aim of this study is to assess the outcome and complications of phacoemulsification combined with pars plana vitrectomy (PPV). Read More

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http://dx.doi.org/10.1155/2019/7918237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441543PMC

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy.

Oxid Med Cell Longev 2019 17;2019:1583656. Epub 2019 Mar 17.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Mitochondrial dysfunction has been implicated in a wide variety of degenerative diseases, including age-related macular degeneration. Damage to mitochondria and mitochondrial DNA accumulates with age in the postmitotic retinal pigment epithelium (RPE), which could lead to RPE cell death and trigger disease. One possible mechanism for cells to avoid cell death is mitophagy, the targeted clearance of damaged mitochondria by autophagy. Read More

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https://www.hindawi.com/journals/omcl/2019/1583656/
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http://dx.doi.org/10.1155/2019/1583656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441541PMC
March 2019
1 Read

Downregulation of lncRNA BANCR participates in the development of retinopathy among diabetic patients.

Exp Ther Med 2019 May 26;17(5):4132-4138. Epub 2019 Mar 26.

Department of Ophthalmology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.

The long non-coding (lnc)RNA B-Raf proto-oncogene, serine/threonine kinase-activated non-protein coding RNA (BANCR) is a well-characterized oncogene, while its potential functions in other diseases remain elusive. In the present study, the possible association of BANCR with diabetic retinopathy was investigated. A total of 244 patients with diabetes were followed up every 6 months for 8 years to record the occurrence of retinopathy. Read More

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http://dx.doi.org/10.3892/etm.2019.7444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468933PMC

Evaluation of serum interferons in patients with age-related macular degeneration.

J Res Med Sci 2019 25;24:24. Epub 2019 Mar 25.

School of Medicine, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Environmental, genetic, and immunological factors may play a role in the pathogenesis of age-related macular degeneration (AMD). In an attempt to better understand the pathogenesis of AMD, in this study, we evaluated the serum interferon (IFN) levels in patients with AMD and compared it with persons without AMD.

Materials And Methods: In this case-control study, 42 patients with AMD and 42 healthy individuals (without AMD) were enrolled as the case and control groups, respectively. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_363_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450131PMC

Anti-Atopic Dermatitis Effect of Extract via Inhibiting the STAT1 Pathway.

Mediators Inflamm 2019 17;2019:3760934. Epub 2019 Mar 17.

Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of Korea.

(SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of body-induced atopic dermatitis (AD) and in tumor necrosis factor- and interferon--stimulated HaCaT keratinocytes. Read More

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http://dx.doi.org/10.1155/2019/3760934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441517PMC

Ocular Fireworks Injuries in Eastern Nigeria: A 3-Year Review.

Niger J Surg 2019 Jan-Jun;25(1):42-44

Department of Ophthalmology, Enugu State University of Science and Technology, Enugu, Nigeria.

Aim: The aim of this study is to determine the incidence and types of ocular injuries caused by fireworks in patients seen at Guinness Eye Centre Onitsha and their effects on vision.

Methods: This was a 3-year retrospective study evaluating case files of patients with ocular fireworks injuries seen at Guinness Eye Centre Onitsha during the Christmas and New Year festivities (2010-2012). Information was extracted into a pro forma and analyzed using Excel, AutoSum, and calculators. Read More

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http://www.nigerianjsurg.com/text.asp?2019/25/1/42/253784
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http://dx.doi.org/10.4103/njs.NJS_29_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452755PMC
April 2019
1 Read

Retinal capillary hemangioblastoma associated with retinochoroidal coloboma in Von Hippel-Lindau disease.

Indian J Ophthalmol 2019 May;67(5):688-690

Department of Ophthalmology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/ijo.IJO_1564_18DOI Listing

Keratoprosthesis optic and carrier corneal graft "noncontact" as a cause of sterile stromal necrosis in a case of Auro KPro implantation.

Indian J Ophthalmol 2019 May;67(5):685-686

Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijo.IJO_1713_18DOI Listing

Commentary: Sealing breaks comfortably- A novel approach to retinopexy without positioning.

Indian J Ophthalmol 2019 May;67(5):681

Vitreo Retina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Thavalakuppam, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_269_19DOI Listing

Coping strategy in persons with low vision or blindness - an exploratory study.

Indian J Ophthalmol 2019 May;67(5):669-676

Department of Ophthalmology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi - 95, India.

Purpose: Coping strategies employed by people with visual disability can influence their quality of life (QoL). We aimed to assess coping in patients with low vision or blindness.

Methods: In this descriptive cross sectional study, 60 patients (25-65 years) with <6/18 best-corrected vision (BCVA) in the better eye and vision loss since ≥6 months were recruited after the institutional ethics clearance and written informed consent. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1655_18DOI Listing

Comparison of torsional amplitudes between emmetropes and myopes using after-image slides.

Indian J Ophthalmol 2019 May;67(5):655-658

Department of Pediatric Ophthalmology, Institute of Ophthalmology, Joseph Eye Hospital, Trichy-1, Tamil Nadu, India.

Purpose: To describe the influence of corrected refractive error on measured torsional fusional amplitudes (TA) by comparing the TA between emmetropes and spectacle corrected myopes, using the after-image slides of the synoptophore, as targets.

Methods: Fifty emmetropes (Group I) and 50 myopes (Group II) with best-corrected acuity of 6/6 in each eye were included in the study. Near point of convergence (NPC), near point of accommodation (NPA), and horizontal fusional amplitudes (HFA) were assessed in all the subjects. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1663_18DOI Listing

Commentary: Ganglion cell complex of retinal layer thickness by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes.

Authors:
Padmaja Sudhakar

Indian J Ophthalmol 2019 May;67(5):653-654

Department of Neurology and Ophthalmology, University of Kentucky, 740 S Limestone, Lexington, KY, USA.

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http://dx.doi.org/10.4103/ijo.IJO_175_19DOI Listing

Macular ganglion cell complex parameters by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes.

Indian J Ophthalmol 2019 May;67(5):648-653

Department of Research, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To compare different macular thickness parameters and peripapillary retinal nerve fiber layer (RNFL) thickness between recently diagnosed cases of multiple sclerosis (MS) without optic neuropathy (ON) and healthy individuals.

Methods: This cross-sectional study was performed between June 2014 and June 2015. All subjects underwent ocular and retinal examination. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1378_18DOI Listing

Commentary: Role of alpha-2 agonists in regional ophthalmic anaesthesia.

Indian J Ophthalmol 2019 May;67(5):641-642

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijo.IJO_635_19DOI Listing

Refractive outcomes of a single-step and a two-step approach for silicone oil removal and cataract surgery.

Indian J Ophthalmol 2019 May;67(5):625-629

Department of Comprehensive Ophthalmology, Sankara Nethralaya, Chennai, India.

Purpose: To compare the intermediate-term refractive outcomes of a single-step and a two-step approach for silicone oil removal (SOR) and cataract surgery.

Methods: Case records of patients who had SOR and phacoemulsification (PE) from 2011 to 2013 at a tertiary center in South India were retrospectively analyzed. A total of 135 eyes that underwent ultrasound biometry (UB) were studied. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1380_18DOI Listing

Commentary: Discharge planning in day-care cataract patients.

Authors:
Anup K Goswami

Indian J Ophthalmol 2019 May;67(5):617-618

Department of Ophthalmology, Swami Dayanand Hospital, Dilshad Garden, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_158_19DOI Listing

Discharge teaching, readiness for discharge, and post-discharge outcomes in cataract patients treated with day surgery: A cross-sectional study.

Indian J Ophthalmol 2019 May;67(5):612-617

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: To investigate the quality of discharge teaching, readiness for hospital discharge (RHD), and post-discharge outcomes (PDO) of cataract patients in a day ward and to explore the relationships among these three variables.

Methods: This cross-sectional study used an opportunistic sample from the ophthalmic day ward in a general hospital in Sichuan province, China. Data were collected using four questionnaires. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1116_18DOI Listing

Commentary: confocal microscopy in iridocorneal endothelial syndrome.

Authors:
Vineet Ratra

Indian J Ophthalmol 2019 May;67(5):610-611

Department of Comprehensive Ophthalmology (Special Interest Glaucoma and Cataract), Medical Research Foundation, Navasuja Sankara Nethralaya, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijo.IJO_154_19DOI Listing

Iridocorneal endothelial syndrome: Evaluation of patient demographics and endothelial morphology by confocal microscopy in an Indian cohort.

Indian J Ophthalmol 2019 May;67(5):604-610

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To evaluate the patient demographics and morphological characteristics of corneal endothelium by in vivo confocal microscopy (IVCM), in patients with Iridocorneal Endothelial (ICE) Syndrome.

Methods: In this retrospective observational series, IVCM acquired endothelial images of patients with ICE syndrome were evaluated. 'ICE cells' morphology was classified as "-" or "+" if they were larger or smaller than contralateral normal endothelium. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1237_18DOI Listing

Objective optical assessment of tear-film quality dynamics in patients with meibomian gland dysfunction and aqueous-deficient dry eye optical quality changes in different dry eye subtypes.

Indian J Ophthalmol 2019 May;67(5):599-603

Department of Ophthalmology, Jinling Hospital of Nanjing Medical University, Nanjing 210002, Jiangsu Province, PR China.

Purpose: To evaluate the optical quality and tear-film dynamics in patients with aqueous-deficient or evaporative subtype of dry eye disease (DED).

Methods: Twenty-five aqueous-deficient dry eye (ADDE) patients, 25 DED patients with meibomian gland dysfunction (MGD), and 25 healthy subjects were included in this study. Vision-related health-targeted quality of life was evaluated using the Ocular Surface Disease Index (OSDI) questionnaire. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1278_18DOI Listing

Comparison of the safety and efficacy of topical Tacrolimus (0.03%) versus dexamethasone (0.05%) for subepithelial infiltrates after adenoviral conjunctivitis.

Indian J Ophthalmol 2019 May;67(5):594-598

Department of Ophthalmology, Laser Eye Clinic, Noida, UP, India.

Purpose: To compare the safety and efficacy of tacrolimus 0.03% ointment with dexamethasone 0.05% ointment for subepithelial infiltrates (SEIs) following adenoviral keratoconjunctivitis (AK). Read More

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http://dx.doi.org/10.4103/ijo.IJO_1352_18DOI Listing

The burden of uncorrected refractive error.

Indian J Ophthalmol 2019 May;67(5):577-578

Editor, Indian Journal of Ophthalmology, Editorial Office: Centre for Sight, Road No 2, Banjara Hills, Hyderabad - 500 034, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_762_19DOI Listing