18,026 results match your criteria Ophthalmology[Journal]


Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity.

Ophthalmol Retina 2018 Sep 21;2(9):963-971. Epub 2018 Mar 21.

Department of Ophthalmology, Duke University, Durham, NC, 27710, USA.

Purpose: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascular junction, a critical location for pathogenesis of ROP, to date this has not been possible . Here we present bedside, non-sedated cross-sectional imaging and analysis of retinal microstructures at the vascular-avascular junction in infants with ROP using handheld spectral-domain optical coherence tomography (SDOCT). Read More

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September 2018
1 Read

Atrophy in Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 15.

Ophthalmol Retina 2018 Oct 2;2(10):1021-1027. Epub 2018 Jun 2.

Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland.

Purpose: To identify the development and progression of macular retinal pigment epithelial atrophy in eyes with neovascular (CNV) age-related macular degeneration (AMD) and to correlate with visual acuity (VA).

Design: Cohort study.

Participants: Age-Related Eye Disease Study 2 (AREDS2) participants with intermediate AMD enrolled in a randomized controlled clinical trial of oral supplements. Read More

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October 2018

Tolerating Subretinal Fluid in Neovascular Age-Related Macular Degeneration Treated With Ranibizumab Using a Treat and Extend Regimen: FLUID Study 24 Month Results.

Ophthalmology 2018 Nov 28. Epub 2018 Nov 28.

Marsden Eye Specialists, 152 Marsden Rd, Parramatta NSW, Australia.

Purpose: To test the hypothesis that tolerating some subretinal fluid (SRF) in patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab using a treat-and-extend (T&E) regimen can achieve similar visual acuity (VA) outcomes as treatment aimed at resolving all SRF.

Design: Multi-center, randomized, 24-month, phase IV, single-masked, non-inferiority clinical trial.

Subjects: Subjects presenting with treatment-naive nAMD. Read More

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November 2018

Correction to: Risk factors of presenile nuclear cataract in health screening study.

BMC Ophthalmol 2018 Nov 30;18(1):308. Epub 2018 Nov 30.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Following publication of the original article [1], the authors notified us of that due to miscommunication during proofing their given names were not presented in their full form, but only using the initials. Read More

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November 2018

Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control.

Ophthalmology 2018 Jul 6. Epub 2018 Jul 6.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Purpose: Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0. Read More

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Evaluation of the corneal epithelium in non-Sjögren's and Sjögren's dry eyes: an in vivo confocal microscopy study using HRT III RCM.

BMC Ophthalmol 2018 Dec 4;18(1):309. Epub 2018 Dec 4.

Doheny Image Reading Center, Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA, 90033, USA.

Background: The corneal epithelium is directly affected in dry eye syndrome. Thus, we attempted to describe the morphological features and evaluate the cellular density within the corneal epithelial layers in patients with non-Sjögren's (NSDE) and Sjögren's syndrome dry eyes (SSDE) by in vivo confocal microscopy (IVCM).

Methods: Central cornea was prospectively imaged by IVCM in 68 clinically diagnosed aqueous tear-deficient dry eyes and 10 healthy age-matched control eyes. Read More

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December 2018

Association of Disorganization of Retinal Inner Layers with Ischemic Index and Visual Acuity in Central Retinal Vein Occlusion.

Ophthalmol Retina 2018 Nov 8;2(11):1125-1132. Epub 2018 Jun 8.

Duke University Department of Ophthalmology, Durham, NC.

Purpose: To determine whether disorganization of retinal inner layers (DRIL) on optical coherence tomography (OCT) is associated with ischemia on ultra-widefield fluorescein angiography (UWFFA) and with visual outcomes in eyes with acute, treatment-naïve central retinal vein occlusion (CRVO).

Design: Retrospective, single-institution, longitudinal cohort study.

Participants: Twenty-five consecutive patients with treatment-naïve CRVO and ≥ 1 year follow-up. Read More

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November 2018

Demographic profile and ocular characteristics of stage 5 retinopathy of prematurity at a referral center in Northwest China: implications for implementation.

BMC Ophthalmol 2018 Nov 29;18(1):307. Epub 2018 Nov 29.

Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Changle West Road 127#, Xi'an, 710032, China.

Background: Severe retinopathy of prematurity (ROP) with extremely unfavorable prognosis among infants can do great damage to individuals and bring tremendous social-economic burden. The purpose of this study is to describe the demographic and ocular characteristics of infants who presented with stage 5 ROP in order to identify reasons why they have become blind, and to identify contributing factors in order to focus great attention on the current ROP program and to inspire more effort in ROP screening in middle income countries.

Methods: A retrospective review of consecutive infants with stage 5 ROP from December 2010 to December 2016 in Department of Ophthalmology, Xijing Hospital. Read More

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November 2018
5 Reads

Prevalence of color blindness among school children in three primary schools of Gish -Abay town district, Amhara regional state, north-west Ethiopia.

BMC Ophthalmol 2018 Nov 26;18(1):306. Epub 2018 Nov 26.

Department of Nursing, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Although there are limited studies, recent data are lacking to accurately determine the magnitude of color blindness in Ethiopia and there is no evidence of such a study in Gish Abay town district. The purpose of thie study was to assess the prevalence of color blindness among school children in Gish Abaya town district, Ethiopia.

Methods: The study used a community-based analytical cross-sectional study design with multistage cluster random sampling technique from September to October 2016. Read More

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November 2018

Orthokeratology for the Prevention of Myopic Progression in Children A report by the American Academy of Ophthalmology.

Ophthalmology 2018 Nov 23. Epub 2018 Nov 23.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.

Objective: To review the published evidence to evaluate the ability of orthokeratology (Ortho-K) treatment to reduce myopic progression in children and adolescents compared with the use of spectacles or daytime contact lenses for standard refractive correction.

Methods: Literature searches of the PubMed database, the Cochrane Library, and the databases of clinical trials were last conducted on May 23, 2017 with no date restrictions but limited to articles published in English. These searches yielded 162 citations, of which 13 were deemed clinically relevant for full-text review and inclusion in this assessment. Read More

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November 2018
2 Reads

Follow up at 5 Years of Non-Fibrotic Scars in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Ophthalmology 2018 Nov 23. Epub 2018 Nov 23.

Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA.

Objective: To describe changes in visual acuity (VA) and macular morphology at 5 years in eyes with non-fibrotic scars (NFS) identified at 1 year in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Design: Prospective cohort study within a randomized clinical trial.

Participants: Participants in CATT. Read More

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November 2018
1 Read

The Effect of Anti-Vascular Endothelial Growth Factor Agents on Intraocular Pressure and Glaucoma A Report by the American Academy of Ophthalmology.

Ophthalmology 2018 Nov 22. Epub 2018 Nov 22.

Harvard Medical School, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Glaucoma Service, Boston, Massachusetts.

Purpose: To assess the effect of intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents on immediate and long-term intraocular pressure (IOP) elevation and glaucoma.

Methods: Literature searches of the PubMed and Cochrane databases, last conducted in April 2018, yielded 253 unique citations. Of these, 41 met the inclusion criteria and were rated according to the strength of evidence. Read More

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November 2018
5 Reads

DeepSeeNet: A deep learning model for automated classification of patient-based age-related macular degeneration severity from color fundus photographs.

Ophthalmology 2018 Nov 21. Epub 2018 Nov 21.

National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH), Bethesda, Maryland, United States.

Purpose: In assessing the severity of age-related macular degeneration (AMD), the Age-Related Eye Disease Study (AREDS) Simplified Severity Scale predicts the risk of progression to late AMD. However, its manual use requires the time-consuming participation of expert practitioners. While several automated deep learning (DL) systems have been developed for classifying color fundus photographs of individual eyes by AREDS severity score, none to date has utilized a patient-based scoring system that employs images from both eyes to assign a severity score. Read More

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November 2018
1 Read

Reply.

Ophthalmology 2018 Nov 20. Epub 2018 Nov 20.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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November 2018
1 Read

Intraoperative relaxed muscle positioning technique results in a tertiary Center for Thyroid Orbitopathy Related Strabismus.

BMC Ophthalmol 2018 Nov 23;18(1):305. Epub 2018 Nov 23.

Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa School of Medicine, 34098, Fatih, Istanbul, Turkey.

Background: Previous techniques resulted with low rates of successful fusion after the surgeries and high necessity of additional surgeries in the treatment of thyroid orbitopathy related strabismus. In this study, reviewing the results of our patients who had surgical correction with relaxed muscle positioning technique due to thyroid orbitopathy related strabismus to evaluate the effectiveness of the surgery was aimed.

Methods: The medical records of 8 patients who had surgical correction with intraoperative relaxed muscle positioning (IRMP) technique were studied retrospectively. Read More

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November 2018

The Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT).

Ophthalmology 2018 Nov 21. Epub 2018 Nov 21.

Dept. of Ophthalmology, St. Michael's Hospital, Toronto, CANADA; Dept. of Ophthalmology & Vision Sciences, University of Toronto, CANADA; Kensington Vision and Research Center, Toronto, CANADA. Electronic address:

Purpose: The optimal surgical intervention to repair certain common configurations of uncomplicated rhegmatogenous retinal detachment (RRD) is unknown. The purpose of this trial was to compare outcomes of pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) for the management of primary RRD.

Design: Prospective randomized controlled trial. Read More

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November 2018
16 Reads
6.130 Impact Factor

A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin.

BMC Ophthalmol 2018 Nov 22;18(1):304. Epub 2018 Nov 22.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, NO.100, Haining Road, Hongkou District, Shanghai, 200080, China.

Background: A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further investigated.

Methods: Photodynamic treatment was conducted on the optic nerve head (ONH) following administration of the photosensitizer. Read More

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November 2018
1 Read

Factors related to amblyopia in congenital ptosis after frontalis sling surgery.

BMC Ophthalmol 2018 Nov 21;18(1):302. Epub 2018 Nov 21.

Department of Ophthalmology, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st RD, Kaohsiung, 81346, Taiwan.

Background: Amblyopia is a main concern in children undergoing frontalis sling surgery for repairing congenital ptosis. This study aimed to evaluate factors related to amblyopia in children undergoing frontalis sling surgery.

Methods: IRB-approved retrospective review of children under the age of 12 who received frontalis sling surgery. Read More

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November 2018
1 Read

Oxidative stress markers in tears of patients with Graves' orbitopathy and their correlation with clinical activity score.

BMC Ophthalmol 2018 Nov 21;18(1):303. Epub 2018 Nov 21.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.

Background: To investigate the concentrations of oxidative stress markers, 8-hydroxy-2'-deoxyquanosine (8-OHdG) and malondialdehyde (MDA), in tears and their correlation with the clinical activity score (CAS) in patients with Graves' orbitopathy (GO) according to disease activity.

Methods: We recruited 27 participants with inactive stage GO, 35 participants with active stage GO, and 25 healthy controls without GO. The tear concentrations of 8-OHdG and MDA were determined by enzyme-linked immunosorbent assay. Read More

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November 2018
1 Read

Targeting Interleukin-23 in the Treatment of Noninfectious Uveitis.

Ophthalmology 2018 Dec 4;125(12):1977-1983. Epub 2018 Jul 4.

Casey Eye Institute, Oregon Health & Science University, Retinal and Vitreous Diseases/Surgery, Ocular Inflammation and Immunology, Portland, Oregon.

The interleukin (IL)-23/IL-17 axis plays a central role in the pathogenesis of immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn's disease, and uveitis. Therefore, targeting the IL-23/IL-17 axis has become the focus of multiple clinical trials for drug development in patients with autoimmune diseases. We briefly describe the biology of the IL-23/IL-17 axis and its relevance to the pathogenesis of experimental and clinical uveitis, and review the monoclonal antibody therapies targeting this pathway. Read More

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December 2018
1 Read

The treatment and risk factors of retinopathy of prematurity in neonatal intensive care units.

BMC Ophthalmol 2018 Nov 20;18(1):301. Epub 2018 Nov 20.

Guangzhou First People's Hospital, Guangzhou city, China.

Background: Retinopathy of prematurity (ROP) is a vascular proliferative disorder of the developing retina and a significant cause of childhood blindness around the world. The incidence of ROP is affected by many factors, and the incidence rate varies from country to country. The purpose of this study is to report the incidence and risk factors of ROP in neonatal intensive care unit (NICU) of Guangzhou First People's Hospital in China. Read More

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November 2018
5 Reads

Ocular Surface Leiomyoma in a Child after Strabismus Repair.

Ophthalmology 2018 Dec;125(12):1968

Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York.

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December 2018
2 Reads

Ocular Metastasis of Cutaneous BRAF Wild-Type Melanoma.

Ophthalmology 2018 Dec;125(12):1966

Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin.

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December 2018

Acquired Cutis Laxa Presenting as Pedunculated Eyelid Plaques in an Adult.

Ophthalmology 2018 Dec;125(12):1952

Department of Ophthalmology, University of Montreal, Montreal, Canada.

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December 2018
2 Reads

Pilomatrixoma Masquerading as Giant Chalazion.

Ophthalmology 2018 Dec;125(12):1936

Wills Eye Hospital, Philadelphia, Pennsylvania.

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December 2018

Conversion of Single Optic Disc Photography into 3-Dimensional Image.

Ophthalmology 2018 Dec;125(12):1873

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

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December 2018

The Future of Keratoconus Screening with Artificial Intelligence.

Authors:
Stephen D Klyce

Ophthalmology 2018 Dec;125(12):1872-1873

Port Washington, New York. Electronic address:

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December 2018

Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury.

BMC Ophthalmol 2018 Nov 20;18(1):300. Epub 2018 Nov 20.

Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Research Institute of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jin Zun Road, Shanghai, 200125, China.

Background: The role of histone deacetylases 6 (HDAC6) has been elucidated in various neurodegenerative diseases. However, the effect of HDAC6 on retinal degenerative processes remains unknown. The aim of this study was to elucidate the potential role of HDAC6 in the retinal ischaemia and reperfusion (I/R) injury model. Read More

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November 2018
2 Reads

Severe ophthalmic manifestation in pituitary-involved granulomatosis with polyangiitis: a case report and literature review.

BMC Ophthalmol 2018 Nov 16;18(1):299. Epub 2018 Nov 16.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China.

Background: Granulomatosis with polyangiitis (GPA), a necrotizing granulomatous disease, very rarely involves the central nervous system (CNS), particularly the pituitary. Delayed treatment may cause permanent bilateral blindness. We report an isolated case of pituitary GPA that manifested as a progressive bilateral temporal visual field (VF) defect and was diagnosed via pituitary biopsy. Read More

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November 2018
5 Reads

The effect of ranibizumab and aflibercept treatment on the prevalence of outer retinal tubulation and its influence on retreatment in neovascular age-related macular degeneration.

BMC Ophthalmol 2018 Nov 14;18(1):298. Epub 2018 Nov 14.

Department of Ophthalmology, Faculty of Medicine, University of Szeged, 10-11 Koranyi fasor, Szeged, 6720, Hungary.

Background: We aimed to analyze the differences in the prevalence of outer retinal tubulation (ORT) in neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) agents, either aflibercept or ranibizumab. Our further aim was to examine the changes in the frequency of injections of ranibizumab before and after ORT appearance.

Methods: Two hundred thirty six eyes of 230 patients were included in the study (184 eyes treated with ranibizumab by pro re nata regimen (PRN), 52 eyes with aflibercept bimonthly) and followed for 6-24 months. Read More

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November 2018
3 Reads

Ectopic orbital meningioma: a retrospective case series.

BMC Ophthalmol 2018 Nov 12;18(1):296. Epub 2018 Nov 12.

The School of Medicine, Nankai University, Tianjin, 300071, China.

Background: To evaluate the ophthalmic manifestations and radiographic features of ectopic orbital meningioma to improve diagnostic accuracy.

Methods: Patient data from patients admitted to our institution during a 217-month period from August 1999 to September 2017 were included. Patient ophthalmic manifestations, radiographic features (CT and MRI), diagnosis, pathology, therapeutic regimens, and prognosis were retrospectively reviewed. Read More

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November 2018
2 Reads

Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies.

BMC Ophthalmol 2018 Nov 12;18(1):297. Epub 2018 Nov 12.

Department of Ophthalmology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Background: Genetic studies have reported contradictory results on the association between the intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and diabetic retinopathy (DR) risk in type 2 diabetic patients. We aimed to perform a systematic literature search and conduct random-effects meta-analysis to provide a quantitative evaluation.

Methods: We searched Pubmed, Embase, Scopus, Web of Science and Wanfang databases from inception up to January 2018. Read More

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November 2018
2 Reads

Corneal higher-order aberrations of the anterior surface, posterior surface, and total cornea after small incision lenticule extraction (SMILE): high myopia versus mild to moderate myopia.

BMC Ophthalmol 2018 Nov 12;18(1):295. Epub 2018 Nov 12.

Eye Center, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: To investigate corneal higher-order aberrations (HOAs) of the anterior surface, posterior surface, and total cornea after small incision lenticule extraction (SMILE) in high myopic and mild to moderate myopic patients.

Methods: This retrospective study included 197 eyes (101 patients) undergoing SMILE surgery. According to the preoperative spherical equivalent (SE), treated eyes were divided into two groups: a high myopic group (more than - 6. Read More

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November 2018
8 Reads

Thirty-month results after the treatment of post-LASIK ectasia with allogenic lenticule addition and corneal cross-linking: a case report.

BMC Ophthalmol 2018 Nov 12;18(1):294. Epub 2018 Nov 12.

School of Medicine, New York University, New York, USA.

Background: To report a first case of lenticule addition and corneal cross-linking for post-LASIK ectasia with associated corneal thinning.

Case Presentation: Lenticule addition followed by corneal cross-linking was performed on the left eye of a patient with post-LASIK ectasia. Postoperatively, the corneal power and elevation were stable with a remarkable improvement in corneal thickness, and the lenticule had merged with the adjacent corneal stroma at 30 months follow-up. Read More

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November 2018
3 Reads

Durability of Diabetic Retinopathy Improvement with As-Needed Ranibizumab: Open-label Extension of RIDE and RISE Studies.

Ophthalmology 2018 Nov 9. Epub 2018 Nov 9.

Genentech, Inc., South San Francisco, California.

Objective: To evaluate durability of diabetic retinopathy (DR) improvements after a change in ranibizumab dosing from monthly to individualized pro re nata (PRN) therapy.

Design: Pooled analysis of the open-label extension (OLE) of RIDE/RISE (NCT00473382/NCT00473330) patients with DR and diabetic macular edema (DME).

Participants: Patients who completed 36-month participation in RIDE/RISE and entered the OLE. Read More

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November 2018
2 Reads

Rhegmatogenous Retinal Detachment In Children: Clinical Factors Predictive Of Successful Surgical Repair.

Ophthalmology 2018 Nov 9. Epub 2018 Nov 9.

Emory Eye Center, Emory University School of Medicine, Atlanta, GA. Electronic address:

Objective: To describe presenting clinical features and surgical techniques that are associated with successful surgical repair of pediatric rhegmatogenous retinal detachment (RRD).

Design: Retrospective interventional case series.

Subjects: 212 eyes of 191 patients, aged 0-18 years, undergoing surgical repair for RRD between 2001 and 2015 with a minimum follow up of 3 months. Read More

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November 2018
4 Reads

Comparison of clinical outcomes of toric intraocular lens, Precizon vs Tecnis: a single center randomized controlled trial.

BMC Ophthalmol 2018 Nov 9;18(1):292. Epub 2018 Nov 9.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.

Background: To compare the clinical outcome of Precizon toric intraocular lens (IOL) (Ophtec Inc.) to that of Tecnis toric IOL (Abbott Medical Optics Inc.). Read More

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November 2018
4 Reads

Pseudophakic mini-monovision: high patient satisfaction, reduced spectacle dependence, and low cost.

BMC Ophthalmol 2018 Nov 9;18(1):293. Epub 2018 Nov 9.

Eye Consultants of Northern Virginia, 8134 Old Keene Mill Rd., Ste. 300, Springfield, VA, 22152, USA.

Background: Cataract surgery with pseudophakic mini-monovision has lower out-of-pocket patient expense than premium multifocal intraocular lenses (IOL). The purpose of this study was to evaluate patient-reported satisfaction and spectacle dependence for key activities of daily living after cataract surgery with pseudophakic mini-monovision. The study also examined statistical relationships between patient demographic variables, visual acuity and satisfaction. Read More

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November 2018
7 Reads
1.070 Impact Factor

Lamellar rotation surgery: a new procedure for repairing upper eyelid defects.

Authors:
Qingji Li

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

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November 2018
2 Reads

Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration.

BMC Ophthalmol 2018 Nov 7;18(1):289. Epub 2018 Nov 7.

Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.

Background: To identify novel biomarkers related to the pathogenesis of dry age-related macular degeneration (AMD), we adopted a human retinal pigment epithelial (RPE) cell culture model that mimics some features of dry AMD including the accumulation of intra- and sub-RPE deposits. Then, we investigated the aqueous humor (AH) proteome using a data-independent acquisition method (sequential window acquisition of all theoretical fragment ion mass spectrometry) for dry AMD patients and controls.

Methods: After uniformly pigmented polarized monolayers of human fetal primary RPE (hfRPE) cells were established, the cells were exposed to 4-hydroxy-2-nonenal (4-HNE), followed by Western blotting, immunofluorescence analysis and ELISA of cells or conditioned media for several proteins of interest. Read More

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November 2018
2 Reads

Retinal-image quality and contrast sensitivity function in eyes with epiretinal membrane: a cross-sectional observational clinical study.

BMC Ophthalmol 2018 Nov 7;18(1):290. Epub 2018 Nov 7.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijng Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.

Background: To investigate the effect of idiopathic epiretinal membrane (ERM) on the retinal-image quality and psychophysical contrast sensitivity function (CSF).

Methods: Forty-four subjects with diagnosis of idiopathic unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffected eyes were set as the control group. Read More

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November 2018

24-Hour Intraocular Pressure Control with Fixed-dose Combination Brinzolamide 1%/Brimonidine 0.2%: A Multicenter, Randomized Trial.

Ophthalmology 2018 Nov 4. Epub 2018 Nov 4.

Novartis Pharmaceuticals Corporation, Fort Worth, TX, USA.

Purpose: To determine the intraocular pressure (IOP)-lowering effect of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) over a 24-hour period.

Design: Prospective, multicenter, double-masked, parallel-group clinical trial conducted at 16 academic and non-academic sites in the USA. Read More

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November 2018
3 Reads

Fundus images analysis using deep features for detection of exudates, hemorrhages and microaneurysms.

BMC Ophthalmol 2018 Nov 6;18(1):288. Epub 2018 Nov 6.

Biosignal Lab, School of Engineering, RMIT University, Melbourne, Australia.

Background: Convolution neural networks have been considered for automatic analysis of fundus images to detect signs of diabetic retinopathy but suffer from low sensitivity.

Methods: This study has proposed an alternate method using probabilistic output from Convolution neural network to automatically and simultaneously detect exudates, hemorrhages and microaneurysms. The method was evaluated using two approaches: patch and image-based analysis of the fundus images on two public databases: DIARETDB1 and e-Ophtha. Read More

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November 2018
3 Reads
1.070 Impact Factor

Implantable collamer lens surgery in patients with primary iris and/or ciliary body cysts.

BMC Ophthalmol 2018 Nov 6;18(1):287. Epub 2018 Nov 6.

Department of Ophthalmology, The People's Hospital of Leshan, 635 Wanghaoer Street, Leshan, Sichuan Province, 614000, People's Republic of China.

Background: The prevalence of primary iris and/or ciliary body cysts is common in myopia, though asymptomatic in nearly all cases. It's a very valuable thing to study the clinical safety and reliability of implantable collamer lens (ICL) surgery in patients with primary iris and/or ciliary body cysts.

Methods: A total of 108 patients (201 eyes) were included in this retrospective study. Read More

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November 2018
5 Reads

Cancer-associated retinopathy preceding the diagnosis of cancer.

BMC Ophthalmol 2018 Nov 3;18(1):285. Epub 2018 Nov 3.

Department of Ophthalmology, National Referral Center for rare Ocular Diseases, Hôpital Cochin, APHP, Université Paris Descartes, Paris, France.

Background: The early diagnosis of cancer is of crucial importance and a key prognostic factor. Cancer-associated retinopathy (CAR) can be symptomatic prior to other manifestations directly related to malignant tumors. The aim of this study was to show that, in selected cases, ophthalmic findings are consistent enough with the diagnosis of CAR to trigger investigations aimed at detecting a previously unknown malignancy. Read More

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November 2018
4 Reads

Complete regression of branching vascular network in polypoidal choroidal vasculopathy by ranibizumab and photodynamic therapy, two case reports.

BMC Ophthalmol 2018 Nov 3;18(1):284. Epub 2018 Nov 3.

Department of Ophthalmology, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Polypoidal choroidal vasculopathy (PCV) consists of polyps that potentially cause massive subretinal hemorrhage and their branching vascular network (BVN) of feeder vessels. Although conventional indocyanine green angiography (IA) has shown anti-vascular endothelial growth factor (VEGF) agents and/or photodynamic therapy (PDT) to successfully induce polyp closure, the BVN appears resistant to these therapies and serves as the origin of recurrent active polyps. Recently introduced optical coherence tomography angiography (OCT-A) enables more frequent angiographic evaluation of polyps and the BVN than does conventional IA since it does not require intravenous fluorescent dye injection and is thus considered non-invasive. Read More

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November 2018