7,489 results match your criteria Ophthalmologica Hungarica Szemeszet [Journal]


Premacular Cell Proliferation Profiles in Tangential Traction Vitreo-Maculopathies Suggest a Key Role for Hyalocytes.

Ophthalmologica 2019 Apr 4:1-7. Epub 2019 Apr 4.

Department of Ophthalmology, Ludwig Maximilian University, Munich, Germany,

Purpose: To compare immunocytochemical and ultrastructural features of premacular tissue surgically removed from eyes with tangential traction vitreo-maculopathies.

Methods: By spectral-domain optical coherence tomography (SD-OCT), premacular tissue was differentiated into premacular proliferation and premacular membrane (PMM). Specimens were harvested during vitrectomy from 10 eyes with macular pucker, lamellar macular hole (LMH) and full-thickness macular hole, and prepared for immunocytochemistry and transmission electron microscopy. Read More

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http://dx.doi.org/10.1159/000495853DOI Listing
April 2019
2 Reads

Same-Day Bilateral Intravitreal Anti-Vascular Endothelial Growth Factor Injections: Experience of a Large Canadian Retina Center.

Ophthalmologica 2019 Mar 29:1-7. Epub 2019 Mar 29.

Department of Ophthalmology, St. Michael's Hospital, Toronto, Ontario, Canada,

Objective: To evaluate the outcomes and complications of bilateral same-day intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.

Methods: This is a single-center, retrospective study that included 524 eyes of 262 patients who received concomitant bilateral intravitreal anti-VEGF injections in 2016 at St. Michael's Hospital, Toronto. Read More

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http://dx.doi.org/10.1159/000499115DOI Listing
March 2019
1 Read
1.867 Impact Factor

Correlation between Visual Function and Structural Characteristics of the Macula in Advanced Retinitis Pigmentosa.

Ophthalmologica 2019 Mar 20:1-9. Epub 2019 Mar 20.

Department of Ophthalmology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea,

We aimed to correlate the visual function and structural characteristics of the retina and choroid in advanced retinitis pigmentosa (RP) patients. A cross-sectional, retrospective review was conducted of medical records of 149 RP patients who reported visual field constriction on a central 30-2 Humphrey visual field chart. Using spectral domain-optical coherence tomography, central foveal thickness (CFT), ellipsoid zone (EZ) length, macular volume (MV), and submacular choroidal thickness (SMChT) were measured. Read More

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http://dx.doi.org/10.1159/000496941DOI Listing

Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study.

Ophthalmologica 2019 19;241(4):211-219. Epub 2019 Mar 19.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,

Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure.

Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers.

Results: Eighty-three cases with 87 identified pathogens were included. Read More

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http://dx.doi.org/10.1159/000496942DOI Listing
March 2019
3 Reads
1.867 Impact Factor

Treatment of Macular Edema after Pars Plana Vitrectomy for Idiopathic Epiretinal Membrane Using Intravitreal Dexamethasone Implant: Long-Term Outcomes.

Ophthalmologica 2019 Mar 19:1-6. Epub 2019 Mar 19.

2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: The aim of this study was to investigate the efficacy and safety of intravitreal dexamethasone implant for the treatment of macular edema after pars plana vitrectomy (PPV) for epiretinal membrane (ERM) removal.

Methods: This prospective study included 27 patients who were diagnosed with macular edema after PPV for ERM removal and who were treated with either intravitreal dexamethasone implant (n = 15) or were observed without intervention (n = 12). Changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were assessed 1, 6, and 12 months -after treatment. Read More

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http://dx.doi.org/10.1159/000496705DOI Listing

Efficacy of Internal Limiting Membrane Flap Techniques with Vitrectomy for Macular Detachment Associated with an Optic Disc Pit.

Ophthalmologica 2019 Mar 22:1-11. Epub 2019 Mar 22.

Vall d'Hebron University Hospital, Barcelona, Spain,

Purpose: To compare the anatomical and functional outcome of adjuvant pars plana vitrectomy (PPV) procedures using the techniques of translocation of an internal limiting membrane (ILM) flap and transplantation of an inverted ILM flap for the treatment of chronic and/or refractory optic disc pit (ODP) maculopathy.

Methods: In this prospective interventional case series study, 9 patients (9 eyes) with chronic and/or refractory ODP maculopathy underwent PPV with either translocation of an ILM flap or transplantation of an inverted ILM flap as adjuvant techniques along with gas tamponade. The anatomical success, rates of macular reattachment, and visual improvement were assessed. Read More

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http://dx.doi.org/10.1159/000495621DOI Listing
March 2019
2 Reads

Effectiveness of Scleral Buckling with a Wide-Field Surgical Microscope and Chandelier Illumination in Retinal Detachment Repair.

Ophthalmologica 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Ophthalmology, College of Medicine, Hallym University, Hwaseong, Republic of Korea,

Purpose: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD).

Methods: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation. Read More

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http://dx.doi.org/10.1159/000496165DOI Listing
February 2019

A Double Inverted Flap Surgical Technique for the Treatment of Idiopathic Lamellar Macular Hole Associated with Atypical Epiretinal Membrane.

Ophthalmologica 2019 Feb 8:1-10. Epub 2019 Feb 8.

Department of Ophthalmology, University of Padova, Padova, Italy.

Objectives: To propose a new technique of a double inverted epiretinal membrane (ERM) and internal limiting membrane (ILM) flap (double flap group) for the treatment of idiopathic lamellar macular hole (LMH) with atypical ERM (AERM) and to compare surgical outcomes to those of the standard technique of ERM and ILM peeling of the fovea including LMH (control group).

Methods: AERM was tomographically defined as a medium reflective thickened membrane above the retinal fiber layers without retinal traction signs. A series of patients affected by LMH with AERM were recruited. Read More

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http://dx.doi.org/10.1159/000496297DOI Listing
February 2019

Microvascular Retinal and Choroidal Changes in Retinal Vein Occlusion Analyzed by Two Different Optical Coherence Tomography Angiography Devices.

Ophthalmologica 2019 Feb 5:1-8. Epub 2019 Feb 5.

Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy,

Purpose: To investigate retinal and choroidal microvascular changes and structural choroidal involvement in retinal vein occlusion (RVO).

Methods: Retrospective analysis of treatment-naïve macular edema secondary to RVO, studied by optical coherence tomography (OCT) and OCT angiography (OCTA), before and after the loading phase of intravitreal injections of ranibizumab (IVR-LP). OCTA was performed using two different devices: AngioVue RTVue XR Avanti (spectral-domain OCTA) and Zeiss PLEX® Elite 9000 (swept-source OCTA). Read More

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http://dx.doi.org/10.1159/000496195DOI Listing
February 2019

Single-Dose Intravitreal Conbercept before Panretinal Photocoagulation as an Effective Adjunctive Treatment in Chinese Proliferative Diabetic Retinopathy.

Ophthalmologica 2019 Jan 30:1-10. Epub 2019 Jan 30.

EENT Hospital, Fudan University, Shanghai, China,

Purpose: This study evaluates the efficacy and patient satisfaction of intravitreal conbercept (IVC) as adjunctive treatment before panretinal photocoagulation (PRP) for Chinese proliferative diabetic retinopathy (PDR) with or without clinically significant macular edema.

Methods: We enrolled 94 patients and categorized them into 2 groups: eyes that received PRP with single-dose IVC (0.5 mg/0. Read More

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http://dx.doi.org/10.1159/000495423DOI Listing
January 2019
3 Reads

Structural and Functional Characterization of the Retinal Effects of Hydroxychloroquine Treatment in Healthy Eyes.

Ophthalmologica 2019 17;241(4):226-233. Epub 2019 Jan 17.

Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Purpose: To evaluate the influence of hydroxychloroquine in visual field and retinal layer thickness.

Methods: This is a retrospective cross-sectional study. Patients taking hydroxychloroquine without signs of hydroxychloroquine retinopathy were included. Read More

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http://dx.doi.org/10.1159/000495308DOI Listing
January 2019
1 Read

One-Year Results of Using a Treat-and-Extend Regimen without a Loading Phase with Anti-VEGF Agents in Patients with Treatment-Naive Diabetic Macular Edema.

Ophthalmologica 2019 17;241(4):220-225. Epub 2019 Jan 17.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland,

Purpose: To evaluate real-life outcomes in treatment-naive patients with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (VEGF) agents using a treat-and-extend regimen without a fixed loading phase.

Methods: Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) measured using optical coherence tomography at baseline and after 1 year of treatment, intervals and number of injections were analyzed. Subgroup analysis was performed to compare anatomical and functional outcomes between patients receiving ranibizumab or aflibercept. Read More

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http://dx.doi.org/10.1159/000495623DOI Listing
January 2019
1 Read

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy.

Ophthalmologica 2019 16;241(4):179-182. Epub 2019 Jan 16.

Sensho-kai Eye Institute, Uji, Japan.

The aim of this narrative mini review is to analyze optical coherence tomography angiography (OCTA) parameters from reports that involved both superficial and deep vascular layers in patients with diabetes and to assess their relevance for the pathogenesis of diabetic retinopathy (DR). Papers published from January 2015 to August 2018 describing the use of OCTA in diabetes were identified and reviewed through a Medline/PubMed search. OCTA studies suggest that parameters are altered in patients with diabetes in all retinal vascular layers. Read More

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http://dx.doi.org/10.1159/000495624DOI Listing
January 2019

Sex-Related Variations of Retinal and Choroidal Thickness and Foveal Avascular Zone in Healthy and Diabetic Children Assessed by Optical Coherence Tomography Imaging.

Ophthalmologica 2019 16;241(3):173-178. Epub 2019 Jan 16.

Department of Ophthalmology, Chair of Ophthalmology and Optometry, Poznan University of Medical Sciences, Poznan, Poland.

Purpose Of The Study: The aim of this study was to investigate the presence of gender differences in the chorioretinal microvasculature of children with and without vascular pathology.

Methods: Healthy and type 1 diabetic children without diabetic retinopathy underwent optical coherence tomography angiography (OCTA) and structural OCT. We measured the foveal avascular zone (FAZ) area in the superficial capillary plexus (SCP) and deep CP (DCP), central retina, and choroid thickness. Read More

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http://dx.doi.org/10.1159/000495622DOI Listing

Prevalence of Retinal Vein Occlusion in Europe: A Systematic Review and Meta-Analysis.

Ophthalmologica 2019 5;241(4):183-189. Epub 2018 Dec 5.

Department of Ophthalmology, University of Bonn, Bonn, Germany,

Purpose: The aim of this study was to examine the prevalence and incidence of retinal vein occlusions (RVO) in Europe.

Methods: A systematic review and meta-analysis of the prevalence and incidence of RVO in Europe according to the Meta-Analyses of Observational Studies in Epidemiology (MOOSE) guidelines was performed in the databases PubMed, Embase and Web of Science. Based on Eurostat data, the total number of affected individuals in the EU was calculated and projected to the year 2050. Read More

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http://dx.doi.org/10.1159/000494224DOI Listing
December 2018
1 Read

Intraoperative Optical Coherence Tomography-Guided Membrane Peeling for Surgery of Macular Pucker: Advantages and Limitations.

Ophthalmologica 2019 9;241(4):234-240. Epub 2018 Nov 9.

Vienna Institute for Research in Ocular Surgery (VIROS), a Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria,

Purpose: Epiretinal membranes (ERMs) are a disorder leading to progressive vision loss and metamorphopsia. The gold standard in therapy is vitrectomy with membrane peeling. The aim of this study was to assess whether the use of intraoperative optical coherence tomography (iOCT), which allows tomographic visualization of the membrane during peeling, enables peeling without staining. Read More

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http://dx.doi.org/10.1159/000493279DOI Listing
November 2018
1 Read

Effectiveness and Safety of Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema: A Real-World Experience.

Ophthalmologica 2019 8;241(1):9-16. Epub 2018 Nov 8.

Retina Private Office, Buenos Aires, Argentina.

Introduction: There are few real-life studies on the intravitreal 0.7-mg dexamethasone implant for the treatment of diabetic macular edema (DME) conducted in Latin America. We aimed to assess the effectiveness and safety of this implant in clinical practice. Read More

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https://www.karger.com/Article/FullText/492132
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http://dx.doi.org/10.1159/000492132DOI Listing
February 2019
18 Reads

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma.

Ophthalmologica 2019 5;241(4):195-201. Epub 2018 Nov 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate spectral domain-optical coherence tomography (SD-OCT) features of untreated circumscribed choroidal hemangioma (CCH), and the optical density (OD) of the associated subretinal fluid (SRF).

Procedures: This international retrospective multicenter study conducted at 5 tertiary retina referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. Read More

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https://www.karger.com/Article/FullText/492948
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http://dx.doi.org/10.1159/000492948DOI Listing
November 2018
12 Reads

The Incidence of Retinal Vein Occlusion in Patients with Pseudoexfoliation Glaucoma: A Retrospective Cohort Study.

Ophthalmologica 2019 2;241(3):130-136. Epub 2018 Nov 2.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Purpose: The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO).

Methods: This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients.

Results: Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0. Read More

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https://www.karger.com/Article/FullText/492401
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http://dx.doi.org/10.1159/000492401DOI Listing
April 2019
15 Reads

Towards Better Safety Standards for Vitreoretinal Medical Devices.

Ophthalmologica 2018 25;240(4):235. Epub 2018 Oct 25.

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http://dx.doi.org/10.1159/000493561DOI Listing
February 2019

Comparison of 577-nm Multispot and Standard Single-Spot Photocoagulation for Diabetic Retinopathy.

Ophthalmologica 2019 17;241(4):202-210. Epub 2018 Oct 17.

Department of Ophthalmology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Objective: To compare two different laser strategies of panretinal photocoagulation for diabetic retinopathy.

Methods: Single-center, randomized study including 41 eyes treated with 577-nm multispot laser with a 20-ms pulse duration (group 1) or a 532-nm single-spot laser with a 100-ms pulse duration (group 2). The outcomes included best-corrected visual acuity (BCVA) and imaging changes at baseline, 6 and 12 months, laser parameters, and results of subjective pain analysis. Read More

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http://dx.doi.org/10.1159/000493280DOI Listing
October 2018
1 Read

Surgical Outcome after Lamellar Macular Hole Associated with Epiretinal Membrane.

Ophthalmologica 2019 11;241(1):56-60. Epub 2018 Oct 11.

Eye Clinic, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Purpose: To evaluate functional and anatomical outcomes after pars plana vitrectomy (PPV) in patients with epiretinal membrane associated with lamellar hole (LH).

Patients And Methods: All patients who underwent PPV with epiretinal membrane peeling associated with an LH from January 2016 to December 2017 were included. Each patient received a complete ophthalmological examination including best-corrected visual acuity using Snellen charts (in decimal form; converted to logMAR) and spectral domain optical coherence tomography (SD-OCT) before surgery as well as 3 months after surgery. Read More

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https://www.karger.com/Article/FullText/493349
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http://dx.doi.org/10.1159/000493349DOI Listing
February 2019
4 Reads

Onset of Retinal Pigment Epithelium Atrophy Subsequent to Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration.

Ophthalmologica 2019 10;241(3):154-160. Epub 2018 Oct 10.

Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.

Purpose: The aim of this study was to evaluate risk factors for the development of retinal pigment epithelium (RPE) atrophy in patients with neovascular age-related macular degeneration (nAMD).

Procedures: This post hoc analysis of the prospective RESPONSE study includes 52 therapy-naive nAMD patients without baseline RPE atrophy, who were treated with ≥9 anti-vascular endothelial growth factor (VEGF) injections for ≥3 years. RPE atrophy was assessed via multimodal imaging. Read More

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http://dx.doi.org/10.1159/000492924DOI Listing
April 2019
2 Reads

Success Rates for Retinal Detachment Repair in Alberta: A Physician Learning Program Initiative.

Ophthalmologica 2019 5;241(3):170-172. Epub 2018 Oct 5.

Department of Ophthalmology, Royal Alexandra Hospital, University of Alberta, Edmonton, Alberta, Canada.

Objective: To identify primary surgical success rates for retinal detachment repair in Alberta and compare functional outcomes of methods of repair.

Methods: Data was retrospectively extracted from the Alberta Health Services Discharge Abstract Database and the National Ambulatory Care Reporting System for all patients diagnosed with retinal detachment and vitreoretinal procedures during the 2008/09 to 2012/13 fiscal years.

Results: Of the 5,433 surgeries for retinal detachment identified, 279 were excluded due to invalid provincial health numbers, unidentified procedure location, and/or treating physician other than an Alberta retina surgeon. Read More

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https://www.karger.com/Article/FullText/492538
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http://dx.doi.org/10.1159/000492538DOI Listing
April 2019
1 Read

Efficacy of Dexamethasone Implants in Uveitic Macular Edema in Cases with Behçet Disease.

Ophthalmologica 2019 21;241(4):190-194. Epub 2018 Sep 21.

Department of Ophthalmology, Uludag University School of Medicine, Bursa, Turkey.

Purpose: Investigation of the efficacy of intravitreal dexamethasone implants (0.7 mg) in patients with Behçet disease (BD) who had cystoid macular edema (CME) despite immunomodulatory treatment.

Materials And Methods: Twenty-seven eyes of 20 patients who had intravitreal dexameth-asone implant injections and follow-up for more than 6 months were included in this study. Read More

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http://dx.doi.org/10.1159/000490674DOI Listing
September 2018
9 Reads

Treatment Effects in Retinal Angiomatous Proliferation Imaged with OCT Angiography.

Ophthalmologica 2019 18;241(3):143-153. Epub 2018 Sep 18.

Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands,

Purpose: This prospective case series is aimed at exploring optical coherence tomographic angiography (OCT-A) as a treatment monitoring tool in patients treated for retinal angiomatous proliferation (RAP).

Methods: Twelve treatment-naïve RAP patients were included, with a median age of 79 years (range 65-90). Patients were imaged with an experimental 1,040-nm swept-source phase-resolved OCT-A instrument before and after treatment. Read More

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http://dx.doi.org/10.1159/000491798DOI Listing
April 2019
1 Read

Stereoscopic Vision in Macular Telangiectasia Type 2.

Ophthalmologica 2019 7;241(3):121-129. Epub 2018 Sep 7.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Purpose: To investigate stereoscopic vision in patients with macular telangiectasia (MacTel) type 2 and correlate paracentral sensitivity loss to reduced stereoscopic function.

Methods: In a prospective single-center study, 50 patients with MacTel type 2 and 25 age-matched controls were investigated. Stereoscopic function was evaluated with Lang I, Titmus, and TNO tests. Read More

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http://dx.doi.org/10.1159/000492134DOI Listing
April 2019
3 Reads

Phase II/III Clinical Trial of Sub-Tenon Injection of Triamcinolone Acetonide (WP-0508ST) for Diabetic Macular Edema.

Ophthalmologica 2019 3;241(3):161-169. Epub 2018 Sep 3.

Department of Ophthalmology, Kyusyu University Hospital, Fukuoka, Japan.

Purpose: To assess the efficacy and safety of sub-Tenon injection of triamcinolone acetonide (WP-0508ST) for the patients with diabetic macular edema (DME).

Methods: This multicenter, randomized, double-masked, comparative, controlled study was performed in 95 patients with DME. The patients were randomly divided into 20 mg WP-0508ST, 40 mg WP-0508ST, and control groups. Read More

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https://www.karger.com/Article/FullText/492135
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http://dx.doi.org/10.1159/000492135DOI Listing
April 2019
35 Reads

Noninfectious Inflammatory Response following Intravitreal Bevacizumab Injections: Description of a Cluster of Cases in Two Centers and a Review of the Literature.

Ophthalmologica 2018 31;240(3):163-166. Epub 2018 Aug 31.

Department of Ophthalmology, Tel-Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: To report a cluster of high incidence of noninfectious inflammatory reaction shortly after bevacizumab injection.

Methods: Data were collected from medical records of consecutive patients who underwent bevacizumab injections and presented with acute uveitis within 1-4 days.

Results: All 7 patients were injected intravitreally with bevacizumab from different batches and presented with visual deterioration. Read More

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http://dx.doi.org/10.1159/000492681DOI Listing
October 2018
25 Reads

Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients.

Ophthalmologica 2019 28;241(2):73-80. Epub 2018 Aug 28.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou,

Purpose: To investigate the etiologies and characteristics of choroidal neovascularization (CNV) in young Chinese patients.

Methods: A retrospective review of young Chinese patients (< 50 years of age) with CNV from January 2010 to June 2016 was performed.

Results: Of the 501 patients (537 eyes) with CNV, 58. Read More

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http://dx.doi.org/10.1159/000492133DOI Listing
March 2019
13 Reads
1.870 Impact Factor

MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration.

Ophthalmologica 2019 28;241(2):61-72. Epub 2018 Aug 28.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Purpose: Currently, no outcome measures are clinically validated and accepted as clinical endpoints by regulatory agencies for drug development in intermediate age-related macular degeneration (iAMD). The MACUSTAR Consortium, a public-private research group funded by the European Innovative Medicines Initiative intends to close this gap.

Procedures: Development of study protocol and statistical analysis plan including predictive modelling of multimodal endpoints based on a review of the literature and expert consensus. Read More

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https://www.karger.com/Article/FullText/491402
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http://dx.doi.org/10.1159/000491402DOI Listing
March 2019
18 Reads

Seasonal Variation in Japanese Central Serous Chorioretinopathy.

Ophthalmologica 2018 27;240(3):150-156. Epub 2018 Aug 27.

Purpose: We investigate seasonal variations found in patients with central serous chorioretinopathy (CSC).

Methods: We retrospectively investigated 201 CSC patients at the Osaka Medical College Hospital from January 2011 to December 2016 and evaluated their seasonal and monthly distributions.

Results: The study population comprised 149 males and 52 females. Read More

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https://www.karger.com/Article/FullText/492136
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http://dx.doi.org/10.1159/000492136DOI Listing
October 2018
2 Reads

A Novel Biomarker in Diabetic Macular Edema with Serous Retinal Detachment: Serum Chitinase-3-Like Protein 1.

Ophthalmologica 2019 21;241(2):90-97. Epub 2018 Aug 21.

Department of Ophthalmology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Purpose: To determine whether serum chitinase-3-like protein 1 (CHI3L1) and interleukin-6 (IL-6) levels correlate with serous retinal detachment (SRD) in diabetic macular edema (DME) using spectral-domain optical coherence tomography (SD-OCT).

Methods: In this cross-sectional case-control study, 394 patients (treatment-naive DME patients, n = 218; diabetic patients without DME, n = 96; nondiabetic controls, n = 80) were included in the study. Eyes were classified according to SD-OCT features of DME: SRD, cystoid macular edema (CMO), and diffuse retinal thickness (DRT). Read More

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http://dx.doi.org/10.1159/000490534DOI Listing
March 2019
1 Read

Long-Term Outcomes of Full-Fluence and Half-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy.

Ophthalmologica 2019 15;241(2):105-115. Epub 2018 Aug 15.

Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Republic of

Purpose: To evaluate the efficacy and safety of full-fluence photodynamic therapy (PDT) and half-fluence PDT in chronic central serous chorioretinopathy (CSC).

Procedures: A retrospective review of CSC patients treated with full-fluence or half-fluence PDT for 12 months was performed. Best-corrected visual acuity (BCVA), central macular thickness (CMT), neural retinal thickness, subfoveal choroidal thickness (SFCT), resolution of subretinal fluid (SRF), and incidence of retinal pigment epithelium (RPE) atrophy at 12, 24, and 36 months were assessed. Read More

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http://dx.doi.org/10.1159/000490773DOI Listing
March 2019
4 Reads

Disorganization of the Retinal Inner Layers after Anti-VEGF Treatment for Macular Edema due to Branch Retinal Vein Occlusion.

Ophthalmologica 2018 8;240(4):229-234. Epub 2018 Aug 8.

Purpose: To evaluate the association between disorganization of the retinal inner layers (DRIL) and visual acuity (VA) after anti-VEGF treatment for macular edema (ME) due to branch retinal vein occlusion (BRVO).

Methods: Sixty eyes of 60 patients were retrospectively investigated. Baseline characteristics and factors analyzed on optical coherence tomography (OCT) examination at the final visit were evaluated in association with VA at the final visit. Read More

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http://dx.doi.org/10.1159/000490809DOI Listing
January 2019
1 Read

Ophthalmologic Manifestations of Wolfram Syndrome: Report of 14 Cases.

Ophthalmologica 2019 27;241(2):116-119. Epub 2018 Jul 27.

Department of Ophthalmology, Hospital de Braga, Braga, Portugal.

Purpose: The aim of this study was to describe ophthalmological abnormalities in 14 cases of Wolfram syndrome belonging to 9 different families.

Methods: Patients were submitted to a complete ophthalmological, neurological, otorhinolaryngological, urological, and genetic evaluation.

Results: Our sample comprised 14 Caucasian patients belonging to 9 different families. Read More

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http://dx.doi.org/10.1159/000490535DOI Listing
March 2019
1 Read

Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration.

Ophthalmologica 2019 26;241(2):81-89. Epub 2018 Jul 26.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.

Purpose: To compare aqueous humor levels of various cytokines between patients with age-related macular degeneration (AMD) and cataract patients.

Methods: Thirteen eyes with wet-type AMD (AMD group) and 14 eyes with cataract (cataract group) were studied. Aqueous humor levels of 11 factors (vascular endothelial growth factor receptors, growth factors, and inflammatory factors) were measured by the suspension array method. Read More

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http://dx.doi.org/10.1159/000490153DOI Listing

Comparison of the Efficacy of Sub-Tenon versus Intravitreal Triamcinolone Acetonide Injection during Cataract Surgery for Diabetic Macular Edema.

Ophthalmologica 2019 24;241(1):17-23. Epub 2018 Jul 24.

Purpose: We compared the efficacy of sub-Tenon triamcinolone acetonide (STTA) to intravitreal triamcinolone aceto-nide (IVTA) injections during cataract surgery (CS) for patients with diabetic macular edema (DME).

Methods: The medical records of 33 eyes (26 patients) with DME which had undergone CS with STTA were compared to those of 34 eyes (27 patients) with DME which had undergone CS with IVTA. Central foveal thickness and best-corrected visual acuity (BCVA) were measured at the baseline and 1, 3, and 6 months after the surgery. Read More

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http://dx.doi.org/10.1159/000489716DOI Listing
February 2019
2 Reads

Incidence and Risk Factors of Ocular Hypertension following Pars Plana Vitrectomy and Silicone Oil Injection.

Ophthalmologica 2018 23;240(3):129-134. Epub 2018 Jul 23.

Eye & Ear University Hospital, Faculté de Médecine, Université Saint-Esprit de Kaslik, Naccache, Lebanon.

Purpose: To evaluate the risk factors for elevated intraocular pressure (IOP) after pars plana vitrectomy (PPV) with silicone oil injection (SOI).

Procedures: This prospective interventional study included 254 consecutive eyes receiving PPV with SOI.

Results: Elevated IOP developed in 48% of the eyes postoperatively. Read More

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http://dx.doi.org/10.1159/000489792DOI Listing
October 2018
4 Reads

Ranibizumab and Bevacizumab but Not Aflibercept Inhibit Proliferation of Primary Human Retinal Pigment Epithelium in vitro.

Ophthalmologica 2019 12;241(3):137-142. Epub 2018 Jul 12.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland,

Aim: Treatment of exudative age-related macular degeneration by using vascular endothelial growth factor (VEGF) antagonists is the gold standard today. So far, several bioactive molecules have been approved for therapeutic use. In this study, we investigate the effects of ranibizumab (Lucentis®), bevacizumab (Avastin®), and aflibercept (Eylea®) on primary human retinal pigment epithelial (hRPE) cells in vitro. Read More

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http://dx.doi.org/10.1159/000490430DOI Listing

Retinal Toxicity of Medical Devices Used during Vitreoretinal Surgery: A Critical Overview.

Ophthalmologica 2018 12;240(4):236-243. Epub 2018 Jul 12.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Retinal toxicity/biocompatibility of medical devices in direct contact with the retina is an important subject for clinicians and scientists. As these effects are not very frequent, there is also a relative lack of information for many clinicians. The past has taught us multiple times that there is a significant safety problem associated with severe loss of vision in affected patients. Read More

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http://dx.doi.org/10.1159/000488504DOI Listing
January 2019
2 Reads

Sequential Dexamethasone and Aflibercept Treatment in Patients with Diabetic Macular Edema: Structural and Functional Outcomes at 52 Weeks.

Ophthalmologica 2019 11;241(2):98-104. Epub 2018 Jul 11.

Hospital General Universitario de Valencia, Valencia, Spain.

Objective: The aim of this paper is to compare intravitreous aflibercept versus dexamethasone implant followed by aflibercept (sequential treatment group) in patients with diabetic macular edema (DME).

Methods: We conducted an observational retrospective study in naïve DME patients, 15 treated only with aflibercept (a monthly injection for the first 5 consecutive doses, followed by an injection every 2 months), and 15 treated with a single dexamethasone implant followed by bimonthly aflibercept. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and qualitative features as well as adverse events were assessed at baseline and at 2, 6, and 12 months. Read More

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http://dx.doi.org/10.1159/000489345DOI Listing
March 2019
4 Reads

Clinical and Genetic Characteristics Analysis of Korean Patients with Stargardt Disease Using Targeted Exome Sequencing.

Ophthalmologica 2019 4;241(1):38-48. Epub 2018 Jul 4.

Department of Ophthalmology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Republic of

Purpose: To investigate genetic mutations in Korean patients with Stargardt disease (STGD) using exome sequencing, and to analyze the correlations between genetic mutations and clinical phenotypes.

Methods: Peripheral venous blood was obtained from 24 clinically diagnosed Korean STGD patients, followed by extraction of genomic DNAs. Using exome sequencing we investigated gene mutations for the adenosine triphosphate-binding cassette, subfamily A, member 4 (ABCA4) elongation of very-long-chain fatty acids 4 (ELOVL4), and prominin 1 (PROM1), and confirmed gene mutations by the direct sequencing of polymerase chain reaction products. Read More

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http://dx.doi.org/10.1159/000490073DOI Listing
February 2019

Towards an Optimized Use of Ocular Corticosteroids: EURETINA Award Lecture 2017.

Ophthalmologica 2018 28;240(2):111-119. Epub 2018 Jun 28.

INSERM, UMRS1138, Team 17, from Physiopathology of Ocular Diseases to Clinical Development, Université Paris Descartes Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France.

Since their discovery, glucocorticoids (GCs) have been extensively used for the treatment of ocular diseases because of their anti-inflammatory, anti-edematous and angiostatic properties. Various GCs have been synthetized to optimize their beneficial anti-inflammatory effects and reduce their effects on sodium retention, identified as a mineralocorticoid effect, leading to a potency and specificity grading of the different GCs. However, the side effects, specificity and potency of GCs are highly tissue specific. Read More

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http://dx.doi.org/10.1159/000489673DOI Listing
August 2018
1 Read

Sutureless Pars Plana Vitrectomy for Intraocular Foreign Bodies.

Ophthalmologica 2018 28;240(3):181-182. Epub 2018 Jun 28.

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http://dx.doi.org/10.1159/000490711DOI Listing
February 2019
1 Read

Real-Life Clinical Effectiveness of Razumab® (the World's First Biosimilar of Ranibizumab) in Retinal Vein Occlusion: A Subgroup Analysis of the Pooled Retrospective RE-ENACT Study.

Ophthalmologica 2019 26;241(1):24-31. Epub 2018 Jun 26.

Background: This subgroup analysis of the RE-ENACT study evaluates the effectiveness of Razumab® (the world's first biosimilar of ranibizumab by Intas Pharmaceuticals Ltd.) in Indian patients with retinal vein occlusion (RVO).

Methods: The data on patients with RVO who had received ≥3 injections of Razumab® between January and August 2016 were analyzed. Read More

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http://dx.doi.org/10.1159/000488602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390449PMC
February 2019
2 Reads

Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy.

Ophthalmologica 2018 26;240(4):191-199. Epub 2018 Jun 26.

Department of Ophthalmology, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain.

Purpose: To analyse superficial peripapillary vascularization in non-arteritic anterior ischaemic optic neuropathy (NAION) at acute and atrophic (3 months) stage.

Procedures: Prospective case-control study including 6 patients with NAION and 10 age-matched healthy controls evaluated with optical coherence tomography angiography (OCT-A; Angioplex-Cirrus) at acute and atrophic stage. Apart from the -commercially provided measurements for vessel density (VD) and perfusion density (PD), a custom image analysis was used to quantify the peripapillary capillary density (PCD). Read More

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http://dx.doi.org/10.1159/000489226DOI Listing
January 2019
5 Reads

Spectral Domain Optical Coherence Tomography Allows the Unification of Clinical Decision Making for the Evaluation of Choroidal Neovascularization Activity.

Ophthalmologica 2019 21;241(1):32-37. Epub 2018 Jun 21.

Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany.

Purpose: This prospective observational clinical study investigated the benefits of spectral domain optical coherence tomography for specialists and residents in the management of neovascular age-related macular degeneration (AMD).

Procedures: The study involved 49 eyes of 44 patients. Patients were advised to present for reevaluation 4 weeks after the administration of the loading dose of vascular endothelial growth factor (VEGF)-inhibitors (3 intravitreal injections every 4 weeks after diagnosis). Read More

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http://dx.doi.org/10.1159/000489344DOI Listing
February 2019
8 Reads