7,443 results match your criteria Ophthalmologica [Journal]


Prevalence of Retinal Vein Occlusion in Europe: A Systematic Review and Meta-Analysis.

Ophthalmologica 2018 Dec 5:1-7. Epub 2018 Dec 5.

Department of Ophthalmology, University of Bonn, Bonn,

Purpose: The aim of this study was to examine the prevalence and incidence of retinal vein occlusions (RVO) in Europe.

Methods: A systematic review and meta-analysis of the prevalence and incidence of RVO in Europe according to the Meta-Analyses of Observational Studies in Epidemiology (MOOSE) guidelines was performed in the databases PubMed, Embase and Web of Science. Based on Eurostat data, the total number of affected individuals in the EU was calculated and projected to the year 2050. Read More

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http://dx.doi.org/10.1159/000494224DOI Listing
December 2018
1 Read

Intraoperative Optical Coherence Tomography-Guided Membrane Peeling for Surgery of Macular Pucker: Advantages and Limitations.

Ophthalmologica 2018 Nov 9:1-7. Epub 2018 Nov 9.

Purpose: Epiretinal membranes (ERMs) are a disorder leading to progressive vision loss and metamorphopsia. The gold standard in therapy is vitrectomy with membrane peeling. The aim of this study was to assess whether the use of intraoperative optical coherence tomography (iOCT), which allows tomographic visualization of the membrane during peeling, enables peeling without staining. Read More

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http://dx.doi.org/10.1159/000493279DOI Listing
November 2018

Effectiveness and Safety of Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema: A Real-World Experience.

Ophthalmologica 2019 8;241(1):9-16. Epub 2018 Nov 8.

Retina Private Office, Buenos Aires, Argentina.

Introduction: There are few real-life studies on the intravitreal 0.7-mg dexamethasone implant for the treatment of diabetic macular edema (DME) conducted in Latin America. We aimed to assess the effectiveness and safety of this implant in clinical practice. Read More

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https://www.karger.com/Article/FullText/492132
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http://dx.doi.org/10.1159/000492132DOI Listing
November 2018
5 Reads

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma.

Ophthalmologica 2018 Nov 5:1-7. Epub 2018 Nov 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate spectral domain-optical coherence tomography (SD-OCT) features of untreated circumscribed choroidal hemangioma (CCH), and the optical density (OD) of the associated subretinal fluid (SRF).

Procedures: This international retrospective multicenter study conducted at 5 tertiary retina referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. Read More

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https://www.karger.com/Article/FullText/492948
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http://dx.doi.org/10.1159/000492948DOI Listing
November 2018
3 Reads

The Incidence of Retinal Vein Occlusion in Patients with Pseudoexfoliation Glaucoma: A Retrospective Cohort Study.

Ophthalmologica 2018 Nov 2:1-7. Epub 2018 Nov 2.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Purpose: The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO).

Methods: This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients.

Results: Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0. Read More

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https://www.karger.com/Article/FullText/492401
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http://dx.doi.org/10.1159/000492401DOI Listing
November 2018
1 Read

Towards Better Safety Standards for Vitreoretinal Medical Devices.

Ophthalmologica 2018 25;240(4):235. Epub 2018 Oct 25.

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http://dx.doi.org/10.1159/000493561DOI Listing
October 2018

Comparison of 577-nm Multispot and Standard Single-Spot Photocoagulation for Diabetic Retinopathy.

Ophthalmologica 2018 Oct 17:1-9. Epub 2018 Oct 17.

Objective: To compare two different laser strategies of panretinal photocoagulation for diabetic retinopathy.

Methods: Single-center, randomized study including 41 eyes treated with 577-nm multispot laser with a 20-ms pulse duration (group 1) or a 532-nm single-spot laser with a 100-ms pulse duration (group 2). The outcomes included best-corrected visual acuity (BCVA) and imaging changes at baseline, 6 and 12 months, laser parameters, and results of subjective pain analysis. Read More

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http://dx.doi.org/10.1159/000493280DOI Listing
October 2018

Surgical Outcome after Lamellar Macular Hole Associated with Epiretinal Membrane.

Ophthalmologica 2019 11;241(1):56-60. Epub 2018 Oct 11.

Eye Clinic, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Purpose: To evaluate functional and anatomical outcomes after pars plana vitrectomy (PPV) in patients with epiretinal membrane associated with lamellar hole (LH).

Patients And Methods: All patients who underwent PPV with epiretinal membrane peeling associated with an LH from January 2016 to December 2017 were included. Each patient received a complete ophthalmological examination including best-corrected visual acuity using Snellen charts (in decimal form; converted to logMAR) and spectral domain optical coherence tomography (SD-OCT) before surgery as well as 3 months after surgery. Read More

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https://www.karger.com/Article/FullText/493349
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http://dx.doi.org/10.1159/000493349DOI Listing
October 2018
4 Reads

Onset of Retinal Pigment Epithelium Atrophy Subsequent to Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration.

Ophthalmologica 2018 Oct 10:1-7. Epub 2018 Oct 10.

Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.

Purpose: The aim of this study was to evaluate risk factors for the development of retinal pigment epithelium (RPE) atrophy in patients with neovascular age-related macular degeneration (nAMD).

Procedures: This post hoc analysis of the prospective RESPONSE study includes 52 therapy-naive nAMD patients without baseline RPE atrophy, who were treated with ≥9 anti-vascular endothelial growth factor (VEGF) injections for ≥3 years. RPE atrophy was assessed via multimodal imaging. Read More

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http://dx.doi.org/10.1159/000492924DOI Listing
October 2018
1 Read

Success Rates for Retinal Detachment Repair in Alberta: A Physician Learning Program Initiative.

Ophthalmologica 2018 Oct 5:1-3. Epub 2018 Oct 5.

Department of Ophthalmology, Royal Alexandra Hospital, University of Alberta, Edmonton, Alberta, Canada.

Objective: To identify primary surgical success rates for retinal detachment repair in Alberta and compare functional outcomes of methods of repair.

Methods: Data was retrospectively extracted from the Alberta Health Services Discharge Abstract Database and the National Ambulatory Care Reporting System for all patients diagnosed with retinal detachment and vitreoretinal procedures during the 2008/09 to 2012/13 fiscal years.

Results: Of the 5,433 surgeries for retinal detachment identified, 279 were excluded due to invalid provincial health numbers, unidentified procedure location, and/or treating physician other than an Alberta retina surgeon. Read More

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https://www.karger.com/Article/FullText/492538
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http://dx.doi.org/10.1159/000492538DOI Listing
October 2018
1 Read

Efficacy of Dexamethasone Implants in Uveitic Macular Edema in Cases with Behçet Disease.

Ophthalmologica 2018 Sep 21:1-5. Epub 2018 Sep 21.

Department of Ophthalmology, Uludag University School of Medicine, Bursa, Turkey.

Purpose: Investigation of the efficacy of intravitreal dexamethasone implants (0.7 mg) in patients with Behçet disease (BD) who had cystoid macular edema (CME) despite immunomodulatory treatment.

Materials And Methods: Twenty-seven eyes of 20 patients who had intravitreal dexameth-asone implant injections and follow-up for more than 6 months were included in this study. Read More

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http://dx.doi.org/10.1159/000490674DOI Listing
September 2018
7 Reads

Treatment Effects in Retinal Angiomatous Proliferation Imaged with OCT Angiography.

Ophthalmologica 2018 Sep 18:1-11. Epub 2018 Sep 18.

Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands.

Purpose: This prospective case series is aimed at exploring optical coherence tomographic angiography (OCT-A) as a treatment monitoring tool in patients treated for retinal angiomatous proliferation (RAP).

Methods: Twelve treatment-naïve RAP patients were included, with a median age of 79 years (range 65-90). Patients were imaged with an experimental 1,040-nm swept-source phase-resolved OCT-A instrument before and after treatment. Read More

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http://dx.doi.org/10.1159/000491798DOI Listing
September 2018

Stereoscopic Vision in Macular Telangiectasia Type 2.

Ophthalmologica 2018 Sep 7:1-9. Epub 2018 Sep 7.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Purpose: To investigate stereoscopic vision in patients with macular telangiectasia (MacTel) type 2 and correlate paracentral sensitivity loss to reduced stereoscopic function.

Methods: In a prospective single-center study, 50 patients with MacTel type 2 and 25 age-matched controls were investigated. Stereoscopic function was evaluated with Lang I, Titmus, and TNO tests. Read More

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http://dx.doi.org/10.1159/000492134DOI Listing
September 2018
1 Read

Phase II/III Clinical Trial of Sub-Tenon Injection of Triamcinolone Acetonide (WP-0508ST) for Diabetic Macular Edema.

Ophthalmologica 2018 Sep 3:1-9. Epub 2018 Sep 3.

Department of Ophthalmology, Kyusyu University Hospital, Fukuoka, Japan.

Purpose: To assess the efficacy and safety of sub-Tenon injection of triamcinolone acetonide (WP-0508ST) for the patients with diabetic macular edema (DME).

Methods: This multicenter, randomized, double-masked, comparative, controlled study was performed in 95 patients with DME. The patients were randomly divided into 20 mg WP-0508ST, 40 mg WP-0508ST, and control groups. Read More

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https://www.karger.com/Article/FullText/492135
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http://dx.doi.org/10.1159/000492135DOI Listing
September 2018
14 Reads

Noninfectious Inflammatory Response following Intravitreal Bevacizumab Injections: Description of a Cluster of Cases in Two Centers and a Review of the Literature.

Ophthalmologica 2018 31;240(3):163-166. Epub 2018 Aug 31.

Department of Ophthalmology, Tel-Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: To report a cluster of high incidence of noninfectious inflammatory reaction shortly after bevacizumab injection.

Methods: Data were collected from medical records of consecutive patients who underwent bevacizumab injections and presented with acute uveitis within 1-4 days.

Results: All 7 patients were injected intravitreally with bevacizumab from different batches and presented with visual deterioration. Read More

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http://dx.doi.org/10.1159/000492681DOI Listing
October 2018
8 Reads

Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients.

Ophthalmologica 2018 Aug 28:1-8. Epub 2018 Aug 28.

Purpose: To investigate the etiologies and characteristics of choroidal neovascularization (CNV) in young Chinese patients.

Methods: A retrospective review of young Chinese patients (< 50 years of age) with CNV from January 2010 to June 2016 was performed.

Results: Of the 501 patients (537 eyes) with CNV, 58. Read More

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http://dx.doi.org/10.1159/000492133DOI Listing
August 2018
2 Reads
1.870 Impact Factor

MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration.

Ophthalmologica 2018 Aug 28:1-12. Epub 2018 Aug 28.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Purpose: Currently, no outcome measures are clinically validated and accepted as clinical endpoints by regulatory agencies for drug development in intermediate age-related macular degeneration (iAMD). The MACUSTAR Consortium, a public-private research group funded by the European Innovative Medicines Initiative intends to close this gap.

Procedures: Development of study protocol and statistical analysis plan including predictive modelling of multimodal endpoints based on a review of the literature and expert consensus. Read More

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https://www.karger.com/Article/FullText/491402
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http://dx.doi.org/10.1159/000491402DOI Listing
August 2018
8 Reads

Seasonal Variation in Japanese Central Serous Chorioretinopathy.

Ophthalmologica 2018 27;240(3):150-156. Epub 2018 Aug 27.

Purpose: We investigate seasonal variations found in patients with central serous chorioretinopathy (CSC).

Methods: We retrospectively investigated 201 CSC patients at the Osaka Medical College Hospital from January 2011 to December 2016 and evaluated their seasonal and monthly distributions.

Results: The study population comprised 149 males and 52 females. Read More

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http://dx.doi.org/10.1159/000492136DOI Listing
October 2018
1 Read

A Novel Biomarker in Diabetic Macular Edema with Serous Retinal Detachment: Serum Chitinase-3-Like Protein 1.

Ophthalmologica 2018 Aug 21:1-8. Epub 2018 Aug 21.

Department of Ophthalmology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Purpose: To determine whether serum chitinase-3-like protein 1 (CHI3L1) and interleukin-6 (IL-6) levels correlate with serous retinal detachment (SRD) in diabetic macular edema (DME) using spectral-domain optical coherence tomography (SD-OCT).

Methods: In this cross-sectional case-control study, 394 patients (treatment-naive DME patients, n = 218; diabetic patients without DME, n = 96; nondiabetic controls, n = 80) were included in the study. Eyes were classified according to SD-OCT features of DME: SRD, cystoid macular edema (CMO), and diffuse retinal thickness (DRT). Read More

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http://dx.doi.org/10.1159/000490534DOI Listing
August 2018
1 Read

Long-Term Outcomes of Full-Fluence and Half-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy.

Ophthalmologica 2018 Aug 15:1-11. Epub 2018 Aug 15.

Purpose: To evaluate the efficacy and safety of full-fluence photodynamic therapy (PDT) and half-fluence PDT in chronic central serous chorioretinopathy (CSC).

Procedures: A retrospective review of CSC patients treated with full-fluence or half-fluence PDT for 12 months was performed. Best-corrected visual acuity (BCVA), central macular thickness (CMT), neural retinal thickness, subfoveal choroidal thickness (SFCT), resolution of subretinal fluid (SRF), and incidence of retinal pigment epithelium (RPE) atrophy at 12, 24, and 36 months were assessed. Read More

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http://dx.doi.org/10.1159/000490773DOI Listing
August 2018
2 Reads

Disorganization of the Retinal Inner Layers after Anti-VEGF Treatment for Macular Edema due to Branch Retinal Vein Occlusion.

Ophthalmologica 2018 8;240(4):229-234. Epub 2018 Aug 8.

Purpose: To evaluate the association between disorganization of the retinal inner layers (DRIL) and visual acuity (VA) after anti-VEGF treatment for macular edema (ME) due to branch retinal vein occlusion (BRVO).

Methods: Sixty eyes of 60 patients were retrospectively investigated. Baseline characteristics and factors analyzed on optical coherence tomography (OCT) examination at the final visit were evaluated in association with VA at the final visit. Read More

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http://dx.doi.org/10.1159/000490809DOI Listing

Ophthalmologic Manifestations of Wolfram Syndrome: Report of 14 Cases.

Ophthalmologica 2018 Jul 27:1-4. Epub 2018 Jul 27.

Department of Ophthalmology, Hospital de Braga, Braga, Portugal.

Purpose: The aim of this study was to describe ophthalmological abnormalities in 14 cases of Wolfram syndrome belonging to 9 different families.

Methods: Patients were submitted to a complete ophthalmological, neurological, otorhinolaryngological, urological, and genetic evaluation.

Results: Our sample comprised 14 Caucasian patients belonging to 9 different families. Read More

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http://dx.doi.org/10.1159/000490535DOI Listing

Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration.

Ophthalmologica 2018 Jul 26:1-9. Epub 2018 Jul 26.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.

Purpose: To compare aqueous humor levels of various cytokines between patients with age-related macular degeneration (AMD) and cataract patients.

Methods: Thirteen eyes with wet-type AMD (AMD group) and 14 eyes with cataract (cataract group) were studied. Aqueous humor levels of 11 factors (vascular endothelial growth factor receptors, growth factors, and inflammatory factors) were measured by the suspension array method. Read More

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http://dx.doi.org/10.1159/000490153DOI Listing

Comparison of the Efficacy of Sub-Tenon versus Intravitreal Triamcinolone Acetonide Injection during Cataract Surgery for Diabetic Macular Edema.

Ophthalmologica 2019 24;241(1):17-23. Epub 2018 Jul 24.

Purpose: We compared the efficacy of sub-Tenon triamcinolone acetonide (STTA) to intravitreal triamcinolone aceto-nide (IVTA) injections during cataract surgery (CS) for patients with diabetic macular edema (DME).

Methods: The medical records of 33 eyes (26 patients) with DME which had undergone CS with STTA were compared to those of 34 eyes (27 patients) with DME which had undergone CS with IVTA. Central foveal thickness and best-corrected visual acuity (BCVA) were measured at the baseline and 1, 3, and 6 months after the surgery. Read More

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http://dx.doi.org/10.1159/000489716DOI Listing
July 2018
2 Reads

Incidence and Risk Factors of Ocular Hypertension following Pars Plana Vitrectomy and Silicone Oil Injection.

Ophthalmologica 2018 23;240(3):129-134. Epub 2018 Jul 23.

Eye & Ear University Hospital, Faculté de Médecine, Université Saint-Esprit de Kaslik, Naccache, Lebanon.

Purpose: To evaluate the risk factors for elevated intraocular pressure (IOP) after pars plana vitrectomy (PPV) with silicone oil injection (SOI).

Procedures: This prospective interventional study included 254 consecutive eyes receiving PPV with SOI.

Results: Elevated IOP developed in 48% of the eyes postoperatively. Read More

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http://dx.doi.org/10.1159/000489792DOI Listing
October 2018
1 Read

Ranibizumab and Bevacizumab but Not Aflibercept Inhibit Proliferation of Primary Human Retinal Pigment Epithelium in vitro.

Ophthalmologica 2018 Jul 12:1-6. Epub 2018 Jul 12.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Aim: Treatment of exudative age-related macular degeneration by using vascular endothelial growth factor (VEGF) antagonists is the gold standard today. So far, several bioactive molecules have been approved for therapeutic use. In this study, we investigate the effects of ranibizumab (Lucentis®), bevacizumab (Avastin®), and aflibercept (Eylea®) on primary human retinal pigment epithelial (hRPE) cells in vitro. Read More

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http://dx.doi.org/10.1159/000490430DOI Listing

Retinal Toxicity of Medical Devices Used during Vitreoretinal Surgery: A Critical Overview.

Ophthalmologica 2018 12;240(4):236-243. Epub 2018 Jul 12.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Retinal toxicity/biocompatibility of medical devices in direct contact with the retina is an important subject for clinicians and scientists. As these effects are not very frequent, there is also a relative lack of information for many clinicians. The past has taught us multiple times that there is a significant safety problem associated with severe loss of vision in affected patients. Read More

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http://dx.doi.org/10.1159/000488504DOI Listing
July 2018
1 Read

Sequential Dexamethasone and Aflibercept Treatment in Patients with Diabetic Macular Edema: Structural and Functional Outcomes at 52 Weeks.

Ophthalmologica 2018 Jul 11:1-7. Epub 2018 Jul 11.

Objective: The aim of this paper is to compare intravitreous aflibercept versus dexamethasone implant followed by aflibercept (sequential treatment group) in patients with diabetic macular edema (DME).

Methods: We conducted an observational retrospective study in naïve DME patients, 15 treated only with aflibercept (a monthly injection for the first 5 consecutive doses, followed by an injection every 2 months), and 15 treated with a single dexamethasone implant followed by bimonthly aflibercept. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and qualitative features as well as adverse events were assessed at baseline and at 2, 6, and 12 months. Read More

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http://dx.doi.org/10.1159/000489345DOI Listing
July 2018
3 Reads

Clinical and Genetic Characteristics Analysis of Korean Patients with Stargardt Disease Using Targeted Exome Sequencing.

Ophthalmologica 2019 4;241(1):38-48. Epub 2018 Jul 4.

Department of Ophthalmology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Republic of

Purpose: To investigate genetic mutations in Korean patients with Stargardt disease (STGD) using exome sequencing, and to analyze the correlations between genetic mutations and clinical phenotypes.

Methods: Peripheral venous blood was obtained from 24 clinically diagnosed Korean STGD patients, followed by extraction of genomic DNAs. Using exome sequencing we investigated gene mutations for the adenosine triphosphate-binding cassette, subfamily A, member 4 (ABCA4) elongation of very-long-chain fatty acids 4 (ELOVL4), and prominin 1 (PROM1), and confirmed gene mutations by the direct sequencing of polymerase chain reaction products. Read More

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http://dx.doi.org/10.1159/000490073DOI Listing

Erratum.

Authors:

Ophthalmologica 2018 1;240(2):72. Epub 2018 Jun 1.

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http://dx.doi.org/10.1159/000490157DOI Listing

Towards an Optimized Use of Ocular Corticosteroids: EURETINA Award Lecture 2017.

Ophthalmologica 2018 28;240(2):111-119. Epub 2018 Jun 28.

INSERM, UMRS1138, Team 17, from Physiopathology of Ocular Diseases to Clinical Development, Université Paris Descartes Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France.

Since their discovery, glucocorticoids (GCs) have been extensively used for the treatment of ocular diseases because of their anti-inflammatory, anti-edematous and angiostatic properties. Various GCs have been synthetized to optimize their beneficial anti-inflammatory effects and reduce their effects on sodium retention, identified as a mineralocorticoid effect, leading to a potency and specificity grading of the different GCs. However, the side effects, specificity and potency of GCs are highly tissue specific. Read More

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http://dx.doi.org/10.1159/000489673DOI Listing

Sutureless Pars Plana Vitrectomy for Intraocular Foreign Bodies.

Ophthalmologica 2018 28;240(3):181-182. Epub 2018 Jun 28.

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http://dx.doi.org/10.1159/000490711DOI Listing

Real-Life Clinical Effectiveness of Razumab® (the World's First Biosimilar of Ranibizumab) in Retinal Vein Occlusion: A Subgroup Analysis of the Pooled Retrospective RE-ENACT Study.

Ophthalmologica 2019 26;241(1):24-31. Epub 2018 Jun 26.

Background: This subgroup analysis of the RE-ENACT study evaluates the effectiveness of Razumab® (the world's first biosimilar of ranibizumab by Intas Pharmaceuticals Ltd.) in Indian patients with retinal vein occlusion (RVO).

Methods: The data on patients with RVO who had received ≥3 injections of Razumab® between January and August 2016 were analyzed. Read More

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http://dx.doi.org/10.1159/000488602DOI Listing
June 2018
1 Read

Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy.

Ophthalmologica 2018 26;240(4):191-199. Epub 2018 Jun 26.

Department of Ophthalmology, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain.

Purpose: To analyse superficial peripapillary vascularization in non-arteritic anterior ischaemic optic neuropathy (NAION) at acute and atrophic (3 months) stage.

Procedures: Prospective case-control study including 6 patients with NAION and 10 age-matched healthy controls evaluated with optical coherence tomography angiography (OCT-A; Angioplex-Cirrus) at acute and atrophic stage. Apart from the -commercially provided measurements for vessel density (VD) and perfusion density (PD), a custom image analysis was used to quantify the peripapillary capillary density (PCD). Read More

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http://dx.doi.org/10.1159/000489226DOI Listing
June 2018
3 Reads

Spectral Domain Optical Coherence Tomography Allows the Unification of Clinical Decision Making for the Evaluation of Choroidal Neovascularization Activity.

Ophthalmologica 2019 21;241(1):32-37. Epub 2018 Jun 21.

Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany.

Purpose: This prospective observational clinical study investigated the benefits of spectral domain optical coherence tomography for specialists and residents in the management of neovascular age-related macular degeneration (AMD).

Procedures: The study involved 49 eyes of 44 patients. Patients were advised to present for reevaluation 4 weeks after the administration of the loading dose of vascular endothelial growth factor (VEGF)-inhibitors (3 intravitreal injections every 4 weeks after diagnosis). Read More

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http://dx.doi.org/10.1159/000489344DOI Listing
June 2018
7 Reads

Comparison of Bevacizumab and Ranibizumab in the Treatment of Type 1 Retinopathy of Prematurity Affecting Zone 1.

Ophthalmologica 2018 19;240(2):99-105. Epub 2018 Jun 19.

Purpose: To investigate the effects of bevacizumab and ranibizumab in the treatment of type 1 retinopathy of prematurity (ROP) affecting zone 1.

Methods: Files of the patients who received intravitreal bevacizumab (IVB) or ranibizumab (IVR) treatment for ROP affecting zone 1 were evaluated retrospectively. Spherical equivalent (SE) and axial length (AXL) measurements were performed at 1 year of adjusted age. Read More

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http://dx.doi.org/10.1159/000489023DOI Listing

Choroidal Thickness in Birdshot Retinochoroiditis Over a 2-Year Period.

Ophthalmologica 2019 19;241(1):49-55. Epub 2018 Jun 19.

Department of Ophthalmology, University Hospital (Centre Hospitalier Universitaire Grenoble-Alpes), Grenoble-Alpes University, Grenoble,

Purpose: To evaluate 2-year choroidal changes in eyes with birdshot retinochoroiditis (BRC).

Methods: Thirteen patients (26 eyes) with BRC were prospectively evaluated during a 2-year period with standard automated perimetry (SAP), fluorescein angiography, indocyanine green angiography and optical coherence tomography (Spectralis Heidelberg Retinal Angiograph + optical coherence tomography). Enhanced-depth imaging optical coherence tomography was performed. Read More

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http://dx.doi.org/10.1159/000485665DOI Listing

Design and Baseline Characteristics of the HELP Study: An Extended and Long-Term Observation of Pathological Myopia in Caucasians.

Ophthalmologica 2018 15;240(3):167-178. Epub 2018 Jun 15.

GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany.

Purpose: To assess the natural disease progression of high myopia in Caucasians considered at risk for the development of myopic choroidal neovascularization (mCNV).

Methods: Subjects were recruited in 25 clinical sites between June 2014 and June 2016. Main inclusion criteria included axial length of ≥26 mm, best-corrected visual acuity ≥0. Read More

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http://dx.doi.org/10.1159/000489180DOI Listing
October 2018
1 Read

Incidence of Macular Holes in the Fellow Eye without Vitreomacular Detachment at Baseline.

Ophthalmologica 2018 12;240(3):135-142. Epub 2018 Jun 12.

Purpose: To determine the rate of macular holes (MH) occurring in the fellow eyes of eyes with MH depending on the vitreomacular interface at baseline.

Methods: This was a retrospective study of patients operated on for idiopathic MH, with persistent vitreofoveal attachment in the fellow eye assessed by spectral-domain optical coherence tomography (SD-OCT). Follow-up lasted 6 months or more, and the main outcome was the occurrence of an MH. Read More

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https://www.karger.com/Article/FullText/488956
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http://dx.doi.org/10.1159/000488956DOI Listing
October 2018
11 Reads

Ranibizumab for the Treatment of Diabetic Macular Oedema in the Real-World Clinical Setting in Portugal: A Multicentre Study.

Ophthalmologica 2019 8;241(1):1-8. Epub 2018 Jun 8.

Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Purpose: The purpose of this study was to evaluate the 2-year outcome of ranibizumab for diabetic macular oedema (DME) in the real-life clinical practice of five ophthalmology departments of the National Health Service (NHS) in Portugal.

Methods: This is a retrospective multicentre study. The clinical records on consecutive patients with DME from clinical practice treated with 0. Read More

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http://dx.doi.org/10.1159/000489046DOI Listing
June 2018
1 Read

Multiple Free Internal Limiting Membrane Flap Insertion in the Treatment of Macular Hole-Associated Retinal Detachment in High Myopia.

Ophthalmologica 2018 6;240(3):143-149. Epub 2018 Jun 6.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: The aim of this paper was to evaluate the efficacy of multiple free internal limiting membrane (ILM) flap insertion in the management of macular hole-associated retinal detachment in high myopia.

Procedures: Eyes receiving operation for macular hole-associated retinal detachment were retrospectively recruited. Those in the study group received ILM peeling and multiple free ILM flap insertion, while those in the control group received ILM peeling only. Read More

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http://dx.doi.org/10.1159/000487337DOI Listing
October 2018

What Effect Does Ethnicity Have on the Response to Ranibizumab in the Treatment of Wet Age-Related Macular Degeneration?

Ophthalmologica 2018 30;240(3):157-162. Epub 2018 May 30.

Ophthalmology Department, Central Middlesex Hospital, London North West University NHS Trust, London, United Kingdom.

Aims: To compare, in a single urban population, the visual outcomes of ranibizumab monotherapy in "White" (W) and "Non-White" (NW) patients with wet age-related macular degeneration (AMD).

Procedures: Prospective data was collected from 434 eyes of 217 patients with wet AMD patients receiving intravitreal ranibizumab. Baseline and monthly LogMAR visual acuities were obtained. Read More

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https://www.karger.com/Article/FullText/486403
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http://dx.doi.org/10.1159/000486403DOI Listing
October 2018
7 Reads

Impact of Metamorphopsia on Quality of Life after Successful Retinal Detachment Surgery.

Ophthalmologica 2018 29;240(3):121-128. Epub 2018 May 29.

Purpose: To determine the impact of metamorphopsia on quality of life after successful retinal detachment (RD) surgery and to determine which retinal changes are related to the most severe distortions.

Design: This was a prospective, observational, consecutive study.

Methods: The study included 58 eyes of 58 consecutive patients who underwent successful RD surgery. Read More

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http://dx.doi.org/10.1159/000486164DOI Listing
October 2018
3 Reads

Aflibercept Treatment in Polypoidal Choroidal Vasculopathy: Results of a Prospective Study in a Caucasian Population.

Ophthalmologica 2018 25;240(4):208-212. Epub 2018 May 25.

Adolphe de Rothschild Foundation, CIC Department, Paris, France.

Introduction: Polypoidal choroidal vasculopathy (PCV) is a choroidal pathology characterized by frequent occurrences of subretinal hemorrhages and resistance to monotherapies such as ranibizumab or bevacizumab intravitreal injections (IVT). The purpose of this study is to evaluate both the anatomical and functional efficacy of aflibercept IVT as a monotherapy in PCV in a Caucasian population.

Methods: We conducted a prospective multicenter study in either treatment-naïve patients with PCV or PVC patients who had not been treated with anti-VEGF within the previous 3 months or with photodynamic therapy (PDT) within the previous 6 months. Read More

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http://dx.doi.org/10.1159/000488808DOI Listing
May 2018
1 Read

Long-Term Results of Combination Treatment with Single-Dose Ranibizumab plus Photodynamic Therapy for Retinal Angiomatous Proliferation.

Ophthalmologica 2018 16;240(4):213-221. Epub 2018 May 16.

University of Athens Medical School, 1st University Eye Clinic, G. Gennimatas General Hospital of Athens, Athens,

Purpose: To present functional and anatomic outcomes of combination therapy with ranibizumab and photodynamic therapy (PDT) in a series of retinal angiomatous proliferation (RAP) cases.

Methods: A total of 17 eyes of 17 patients with RAP were included. Thirteen eyes were treatment naïve and 4 were already on ranibizumab monotherapy. Read More

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http://dx.doi.org/10.1159/000487610DOI Listing
May 2018
3 Reads

Subfoveal Choroidal Thickness in Eyes with Neovascular Age-Related Macular Degeneration Treated with Anti-Vascular Endothelial Growth Factor Agents.

Ophthalmologica 2018 16;240(4):200-207. Epub 2018 May 16.

Purpose: We aimed to assess the subfoveal choroidal thickness (SFChT) and the effect of treatment with anti-vascular endothelial growth factor (anti-VEGF) agents on the SFChT in age-related macular degeneration (AMD) subtypes.

Methods: We enrolled 128 eyes of 107 patients with neovascular AMD (60 women; 47 men; mean age, 73.6 ± 8. Read More

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http://dx.doi.org/10.1159/000488254DOI Listing
May 2018
4 Reads

Comparison between Nonmydriatic Spectral Domain Optical Coherence Tomography and Conventional Ophthalmologic Examination in Detecting Adult Macular Pathology.

Ophthalmologica 2018 15;240(4):222-228. Epub 2018 May 15.

Department of Ophthalmology, American University of Beirut Medical Center, Beirut,

Objective: To compare nonmydriatic spectral domain optical coherence tomography (NMOCT) to comprehensive ophthalmologic evaluation (COE) in detecting adult macular abnormalities.

Methods: This is a single-reader observational pilot study of adults older than 50 years with no known ophthalmologic problems to assess the correlation between NMOCT and COE in detecting macular abnormalities classified as epiretinal, intraretinal, subretinal, or a combination thereof. Subjects underwent NMOCT of the macula followed by COE which included a dilated fundus examination and ancillary tests as needed. Read More

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http://dx.doi.org/10.1159/000484576DOI Listing
May 2018
5 Reads

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity.

Ophthalmologica 2018 9;240(2):106-110. Epub 2018 May 9.

Purpose: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP).

Methods: We enrolled 112 patients (age: 6-15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. Read More

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http://dx.doi.org/10.1159/000488368DOI Listing
August 2018
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Optical Coherence Tomography Angiography to Quantify Choroidal Neovascularization in Response to Aflibercept.

Ophthalmologica 2018 8;240(2):90-98. Epub 2018 May 8.

Purpose: To investigate the microvascular changes in choroidal neovascularization (CNV) using optical coherence tomography angiography (OCTA) during anti-vascular endothelial growth factor (VEGF) therapies.

Methods: We retrospectively collected data on consecutive treatment-naïve eyes with typical age-related macular degeneration that initially received 3 aflibercept injections. OCTA was performed at baseline and at 1, 2, and 4 months of follow-up. Read More

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http://dx.doi.org/10.1159/000487611DOI Listing
August 2018
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Influence of the Vitreoretinal Interface on the Treatment with Anti-VEGF for Exudative Age-Related Macular Degeneration.

Ophthalmologica 2018 7;240(1):29-36. Epub 2018 May 7.

Department of Ophthalmology, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Purpose: To investigate the influence of the vitreoretinal interface on the outcomes of different ranibizumab regimens for exudative age-related macular degeneration.

Methods: We conducted a retrospective subanalysis of 2 prospective clinical trials. Patients were treated with ranibizumab for 12 months according to 3 different regimens: pro-re-nata (PRN), treat and extend (T&E), and monthly. Read More

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http://dx.doi.org/10.1159/000488010DOI Listing
June 2018
2 Reads