1,056 results match your criteria Open Medicine[Journal]


"If my family is happy, then I am happy": Quality-of-life determinants of parents of school-age children.

SAGE Open Med 2019 2;7:2050312119828535. Epub 2019 Feb 2.

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.

Objective: Obesity is a public health concern for children and adults and effective obesity prevention programming is needed urgently. The effectiveness of health-related messaging and interventions is influenced by the way content is framed. HomeStyles is an obesity prevention program, which aims to promote health through the frame of improved quality of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119828535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360638PMC
February 2019

Assessment of pharmacologic prophylaxis use against stress ulcer in the medical wards of University of Gondar Hospital.

SAGE Open Med 2019 2;7:2050312119827409. Epub 2019 Feb 2.

Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Critically ill patients with moderate-to-severe physiologically stressful event are at high risk of developing stress ulcers. The use of pharmacological prophylaxis significantly reduces the incidence of stress ulcer in high-risk patients.

Objective: The aim of this study was to assess the use of pharmacological prophylaxis for stress ulcer in the medical wards of University of Gondar Hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119827409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360640PMC
February 2019

Pattern of and reasons for antiretroviral therapy regimen change among adult HIV/AIDS patients at regional hospital in Eastern Ethiopia: A 10-year retrospective study.

SAGE Open Med 2019 1;7:2050312119827092. Epub 2019 Feb 1.

Addis Private Pharmacy, Harar, Ethiopia.

Objectives: Despite the successes of treatment with antiretroviral therapy in reducing morbidity and mortality among HIV-infected patients, long-term sustainability of the initial regimen has become challenging. Therefore, this study is aimed to address pattern of and reasons for change of antiretroviral therapy regimens among HIV/AIDS patients at Jugel Hospital, Eastern Ethiopia.

Methods: A retrospective cross-sectional study was conducted to review medical records of 220 patients who had been on treatment and experienced regimen change at least once from September 2006 to August 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119827092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360642PMC
February 2019
1 Read

Effect of nutritional status of pregnant women on birth weight of newborns at Butajira Referral Hospital, Butajira, Ethiopia.

SAGE Open Med 2019 29;7:2050312119827096. Epub 2019 Jan 29.

Department of Medical Laboratory Sciences, School of Medicine, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia.

Back Ground: Maternal nutritional status influences the developmental environment of the fetus which consequently affects the birth weight of the newborn. However, the association between maternal nutritional factors and birth weight is complex and is not well characterized in Ethiopia.

Objective: To assess the effect of maternal anthropometry and biochemical profile on birth weight of babies at Butajira Referral Hospital, Butajira, Ethiopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119827096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351719PMC
January 2019

Association between leisure-time physical activity and sedentary behavior with cardiometabolic health in the ELSA-Brasil participants.

SAGE Open Med 2019 30;7:2050312119827089. Epub 2019 Jan 30.

Institute of Collective Health, Federal University of Bahia (UFBA), Salvador, Brazil.

Objectives: To assess associations, both individually and in combination, between leisure-time physical activity and sedentary behavior, and cardiometabolic health.

Methods: This cross-sectional study included 13,931 civil servants participating in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Leisure-time physical activity was analyzed using the leisure-time domain of the long-form International Physical Activity Questionnaire, while questions related to cumulative sitting time and leisure-based screen time on a weekday and on one day on the weekend were used to establish sedentary behavior. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119827089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354306PMC
January 2019

Baby food and bedtime: Evidence for opposite phenotypes from different genetic and epigenetic alterations in Prader-Willi and Angelman syndromes.

SAGE Open Med 2019 28;7:2050312118823585. Epub 2019 Jan 28.

Simon Fraser University, Burnaby, BC, Canada.

Prader-Willi and Angelman syndromes are often referred to as a sister pair of neurodevelopmental disorders, resulting from different genetic and epigenetic alterations to the same chromosomal region, 15q11-q13. Some of the primary phenotypes of the two syndromes have been suggested to be opposite to one another, but this hypothesis has yet to be tested comprehensively, and it remains unclear how opposite effects could be produced by changes to different genes in one syndrome compared to the other. We evaluated the evidence for opposite effects on sleep and eating phenotypes in Prader-Willi syndrome and Angelman syndrome, and developed physiological-genetic models that represent hypothesized causes of these differences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118823585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350130PMC
January 2019
1 Read

Physical activity promotion in Manitoba: Strengths, needs, and moving forward.

SAGE Open Med 2019 28;7:2050312118822910. Epub 2019 Jan 28.

Manitoba Centre for Health Policy, & Departments of Community Health Sciences and Family Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Objectives: To present findings of a workshop with physical activity professionals in Manitoba, Canada, to facilitate the enhancement of physical activity promotion efforts by exploring (1) effective physical activity strategies, (2) methods to strengthen physical activity strategies, (3) challenges in implementing physical activity strategies in Manitoba, and (4) strategies to support collaboration.

Methods: The Manitoba Research Chair in Primary Prevention hosted a workshop for 54 stakeholders in Manitoba. Qualitative and quantitative data obtained from the workshop were analyzed using qualitative content analysis and univariate descriptive analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350162PMC
January 2019

Results of minimally invasive Achilles tendon scraping and plantaris tendon removal in patients with chronic midportion Achilles tendinopathy: A longer-term follow-up study.

SAGE Open Med 2019 30;7:2050312118822642. Epub 2019 Jan 30.

Department of Community Medicine and Rehabilitation, Sports Medicine Unit, Umeå University, Umeå, Sweden.

Background: Treatment with ultrasound and colour Doppler-guided minimally invasive Achilles tendon scraping and plantaris tendon removal has shown promising short-term results in patients with chronic painful midportion Achilles tendinopathy.

Methods: In a follow-up study, 182 consecutive patients (241 tendons) who had undergone Achilles tendon scraping and plantaris tendon removal were contacted on telephone by an independent investigator. The patients who answered the telephone call were included, and they answered a questionnaire on telephone and then also sent their written answers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354305PMC
January 2019
1 Read

Feasibility of population screening tests to establish a healthy ageing trajectory.

SAGE Open Med 2019 11;7:2050312118822440. Epub 2019 Jan 11.

Department of Family & Community Medicine, University of Toronto, Toronto, ON, Canada.

Objectives: There are no agreed comprehensive tests for age-related changes to physical, emotional, mental and social functioning. Research into declining function focuses on those 75 years and older and little is known about age-related changes in younger people. The aims of this project were (1) to ascertain a comprehensive test battery that could underpin community-based health screening programmes for people aged 40-75 years and pilot both (2) community-based recruitment and (3) the utility, acceptability, response burden and logistics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350131PMC
January 2019

subspecies engineered to produce mycosporin-like amino acids in colorectal cancer prevention.

SAGE Open Med 2019 22;7:2050312119825784. Epub 2019 Jan 22.

Clinic of Gastroenterology, Adana Numune Research and Education Hospital, University of Health Sciences, Adana, Turkey.

Colorectal cancer is the third most common cancer and the third leading cause of cancer-related death. The pathogensesis of colorectal cancer involves a multi-step and multi-factorial process. Disruption of the gut microbiota has been associated with gastrointestinal diseases such as colorectal cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119825784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348500PMC
January 2019
2 Reads

The impact of body mass index on resource utilization and outcomes of children admitted to a pediatric intensive care unit.

SAGE Open Med 2019 22;7:2050312119825509. Epub 2019 Jan 22.

Division of Critical Care Medicine, Nicklaus Children's Hospital, Miami, FL, USA.

Introduction: Obesity is associated with poor health outcomes but may be protective in intensive care unit patients. The objective of this study is to describe the characteristics of underweight, normal weight, and obese children, and to compare their length of stay, resource utilization, and mortality.

Methods: The charts of 1447 patients who were admitted to a tertiary-level pediatric intensive care unit during 1 calendar year were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119825509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348573PMC
January 2019
1 Read

Protocol for constructing a support model for family caregivers of people with dementia: Barriers and requirements.

Authors:
Chia-Ming Yen

SAGE Open Med 2019 16;7:2050312118824860. Epub 2019 Jan 16.

Medical Center of Aging Research, China Medical University Hospital, Taichung, R.O.C.

Background: This report describes a protocol for determining the barriers and requirements of family caregivers for people with dementia. The perspectives of healthcare professionals, family caregivers, and dementia patients will be collected and analyzed to construct a support model of requirements.

Methods: An in-depth interview and care diary will be adopted during Phase I. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118824860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348553PMC
January 2019

Impact of chronic khat ( Forsk) chewing on pulmonary function test and oxygen saturation in humans: A comparative study.

SAGE Open Med 2019 11;7:2050312118824616. Epub 2019 Jan 11.

Department of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia.

Background: Chronic consumption of khat affects many organ systems and leads to various health disturbances in the chewers. Few studies examined the acute effects of khat ingestion on lung function parameters. However, studies which assessed the long-term effects of khat chewing on pulmonary function parameters and oxygen saturation are lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118824616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348536PMC
January 2019
1 Read

Rural-urban comparison of routine immunization utilization and its determinants in communities in Anambra States, Nigeria.

SAGE Open Med 2019 14;7:2050312118823893. Epub 2019 Jan 14.

Department of Health Administration and Management, College of Medicine, University of Nigeria, Enugu, Nigeria.

Objectives: The study determined the levels of geographic differences in the utilization of routine immunization between households in an urban and a rural community. It also identified and compared the determinants of utilization of routine immunization in the two geographic areas.

Method: The study was undertaken in two randomly selected communities (one rural and one urban) in Anambra State, Nigeria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118823893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348577PMC
January 2019
1 Read

Non-critical healthcare tools as a potential source of healthcare-acquired bacterial infections in eastern Ethiopia: A hospital-based cross-sectional study.

SAGE Open Med 2019 2;7:2050312118822627. Epub 2019 Jan 2.

School of Medicine, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

Background: Outbreaks of healthcare-acquired infections have been linked to contaminated medical devices such as electronic thermometers, sphygmomanometers, stethoscopes, latex gloves, masks, neckties, white coats and other.

Objective: The aim of this study was to assess non-critical healthcare tools as a potential source of healthcare-acquired bacterial infections and associated factors in public health hospitals of Harar, eastern Ethiopia from March 2016 to February 2017.

Methods: A hospital-based cross-sectional study was conducted on 212 non-critical healthcare tools owned by different health professionals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317151PMC
January 2019

Hypertensive heart disease: Benefit of carvedilol in hemodynamic, left ventricular remodeling, and survival.

SAGE Open Med 2019 8;7:2050312118823582. Epub 2019 Jan 8.

Universidade Nove de Julho-UNINOVE, São Paulo, Brasil.

Objectives: The aim of this study was to determine if carvedilol improved structural and functional changes in the left ventricle and reduced mortality in patients with hypertensive heart disease.

Methods: Blood pressure, heart rate, echocardiographic parameters, and laboratory variables, were assessed pre and post treatment with carvedilol in 98 eligible patients.

Results: Carvedilol at a median dose of 50 mg/day during the treatment period in hypertensive heart disease lowered blood pressure 10/10 mmHg, heart rate 10 beats/min, improved left ventricular ejection fraction from baseline to follow-up (median: 6 years) (36%-47%)) and reduced left ventricular end-diastolic and end-systolic dimensions (62 vs 56 mm; 53 vs 42 mm, respectively, all p-values <0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118823582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327325PMC
January 2019

Expressed emotions and experiences from relatives regarding having a family member living in a nursing home for older people.

SAGE Open Med 2019 9;7:2050312118823414. Epub 2019 Jan 9.

Department of Nursing, Umeå University, Örnsköldsvik, Sweden.

Objectives: The purpose of this study was to describe the topics relatives with a family member in a nursing home for older persons choose to talk about and focus on when participating in a nurse-led "Family Health Conversations" intervention. Family Health Conversations consisted of a series of three nurse-led conversations with each family, with a 2-week interval between meetings.

Methods: The Family Health Conversations meetings were tape-recorded and analyzed using qualitative content methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118823414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329026PMC
January 2019

Isometric knee extension force in Japanese type 2 diabetic patients without apparent diabetic polyneuropathy: Data from the Multicenter Survey of the Isometric Lower Extremity Strength in Type 2 Diabetes study.

SAGE Open Med 2019 8;7:2050312118823412. Epub 2019 Jan 8.

Diabetes Center, Kochi Memorial Hospital, Kochi, Japan.

Objectives: To determine standard reference values for isometric knee extension force using a cohort of Japanese type 2 diabetic patients without diabetic polyneuropathy.

Methods: Patient data were collected from the Multicenter Survey of the Isometric Lower Extremity Strength in Type 2 Diabetes study and compared with previously published data of healthy control subjects. In total, we enrolled 898 patients with type 2 diabetes aged 30-87 years, who did not have diabetic polyneuropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118823412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329036PMC
January 2019

Exploratory analysis of comparative clinical trials used for marketing approval in patients with type 2 diabetes in Japan.

SAGE Open Med 2019 8;7:2050312118823407. Epub 2019 Jan 8.

Laboratory of Pharmaceutical Regulation and Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Background/objectives: The results of phase 2 and 3 clinical trials, which justify decisions regarding marketing approval for new drugs, are used for comparison of drugs in the post-marketing phase. A number of meta-analyses of approved antidiabetics have been performed, but the heterogeneity of trials has not been fully examined. The aim of this study was to explore factors that may influence baseline HbA1c in trial samples and treatment outcomes (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118823407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329034PMC
January 2019

How handling missing data may impact conclusions: A comparison of six different imputation methods for categorical questionnaire data.

SAGE Open Med 2019 8;7:2050312118822912. Epub 2019 Jan 8.

Norwegian Centre for Addiction Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Objectives: Missing data is a recurrent issue in many fields of medical research, particularly in questionnaires. The aim of this article is to describe and compare six conceptually different multiple imputation methods, alongside the commonly used complete case analysis, and to explore whether the choice of methodology for handling missing data might impact clinical conclusions drawn from a regression model when data are categorical.

Methods: In addition to the commonly used complete case analysis, we tested the following six imputation methods: multiple imputation using expectation-maximization with bootstrapping, multiple imputation using multiple correspondence analysis, multiple imputation using latent class analysis, multiple hot deck imputation and multivariate imputation by chained equations with two different model specifications: logistic regression and random forests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329020PMC
January 2019
3 Reads

A cross-sectional study of the relationship between reported human papillomavirus vaccine exposure and the incidence of reported asthma in the United States.

SAGE Open Med 2019 8;7:2050312118822650. Epub 2019 Jan 8.

Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA.

Objectives: Asthma is a chronic disorder that affects persons of all ages impacting the quality of their lives. This cross-sectional hypothesis-testing study evaluated the relationship between human papillomavirus vaccine and the risk of an incident asthma diagnosis in a defined temporal period post-vaccination.

Methods: The 2015-2016 National Health and Nutrition Examination Survey data were examined for a group of 60,934,237 weighted persons between 9 and 26 years old in Statistical Analysis Software. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329017PMC
January 2019
1 Read

Grounded theory research: A design framework for novice researchers.

SAGE Open Med 2019 2;7:2050312118822927. Epub 2019 Jan 2.

College of Health and Medicine, University of Tasmania, Australia, Hobart, TAS, Australia.

Background: Grounded theory is a well-known methodology employed in many research studies. Qualitative and quantitative data generation techniques can be used in a grounded theory study. Grounded theory sets out to discover or construct theory from data, systematically obtained and analysed using comparative analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318722PMC
January 2019
1 Read

Clinical features of benign paroxysmal positional vertigo of the posterior semicircular canal.

SAGE Open Med 2019 2;7:2050312118822922. Epub 2019 Jan 2.

Audiology and ENT Clinic, University of Ferrara, Ferrara, Italy.

Objective: The aim of this study was to evaluate the relationship between age, gender and affected ear, in patients presenting benign paroxysmal positional vertigo.

Methods: This was a retrospective study. Data from benign paroxysmal positional vertigo clinical reports (January 2009-December 2014) were analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317147PMC
January 2019
1 Read

Engaging patients and caregivers in establishing research priorities for aortic dissection.

SAGE Open Med 2019 1;7:2050312118822632. Epub 2019 Jan 1.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objectives: The aim of this study was to establish the top 10 research uncertainties in aortic dissection together with the patient organization Aortic Dissection Association Scandinavia using the James Lind Alliance concept.

Methods: A pilot survey aiming to identify uncertainties sent to 12 patients was found to have high content validity (scale content validity index = 0.91). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317148PMC
January 2019
1 Read

Reducing errors in the administration of medication with infusion pumps in the intensive care department: A lean approach.

SAGE Open Med 2019 2;7:2050312118822629. Epub 2019 Jan 2.

Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Background: Medication errors occur frequently and may potentially harm patients. Administering medication with infusion pumps carries specific risks, which lead to incidents that affect patient safety.

Objective: Since previous attempts to reduce medication errors with infusion pumps failed in our intensive care unit, we chose the Lean approach to accomplish a 50% reduction of administration errors in 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118822629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318721PMC
January 2019

The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Susceptibility to Late-onset Alzheimer's Disease.

Open Med (Wars) 2019 4;14:32-40. Epub 2019 Jan 4.

Key Laboratory of Internal Medicine, The Frist Hospital Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, P.R. China.

Folate metabolism makes a crucial contribution towards late-onset Alzheimer's disease (LOAD). Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. We hypothesize that there is an association of C677T polymorphism in the MTHFR gene with the susceptibility to LOAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2019-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325648PMC
January 2019
4 Reads

Patient expectations of hypertension and diabetes medication: Excessive focus on short-term benefits.

SAGE Open Med 2018 24;6:2050312118821119. Epub 2018 Dec 24.

Section of General Internal Medicine, Department of Medicine, The University of Chicago Medicine, Chicago, IL, USA.

Objectives: The objectives of this study are to assess patient perspectives on their perceived benefits of hypertension and diabetes medications and determine associations between perceived benefits and demographics, adherence, and disease control.

Methods: We interviewed 60 adults with type 2 diabetes and hypertension on oral medications. Participants were asked what benefits they expected from taking their medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118821119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305947PMC
December 2018
4 Reads

Discontinuation of Imatinib Mesylate could Improve Renal Impairment in Chronic Myeloid Leukemia.

Open Med (Wars) 2019 24;14:22-24. Epub 2018 Dec 24.

Hacettepe University School of Medicine, Department of Hematology, Ankara, Turkey.

We aim to report a CML case that had fluid retention and serum creatinine increase under long-term imatinib mesylate (IM) treatment. A 68-year-old woman was diagnosed with chronic myeloid leukemia, and IM was started in 2002 with a dose of 400 mg/day. She had achieved complete hematological, molecular and cytogenetic remission under IM treatment. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019
Publisher Site
http://dx.doi.org/10.1515/med-2019-0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310919PMC
December 2018
7 Reads

Associations between Ambient Temperature and Acute Myocardial Infarction.

Open Med (Wars) 2019 24;14:14-21. Epub 2018 Dec 24.

School of Management, Shanxi Medical University, Taiyuan 030000, Shanxi, China.

Background: The associations between incidence of acute myocardial infarction (AMI) and the ambient temperature were mixed in prior studies.

Methods: Data of 2033 consecutive admissions of AMI in a central tertiary hospital in North China from 1st Jan 2003 to 31st Dec 2011 were collected. The weather data in this period were from the local meteorological department. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310921PMC
December 2018

Pediatric Acute Paradoxical Cerebral Embolism with Pulmonary Embolism Caused by Extremely Small Patent Foramen Ovale.

Open Med (Wars) 2019 24;14:10-13. Epub 2018 Dec 24.

Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.

Herein, we report a pediatric case of acute paradoxical cerebral embolism complicated by serious acute pulmonary embolism that was caused by an extremely small patent foramen ovale (PFO). The patient had no medical history suggestive of any other reason. Paradoxical cerebral embolism may occur even with an extremely small PFO because of the increased right-side pressure of the heart and a resulting right-to-left shunt from the acute pulmonary embolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310914PMC
December 2018
2 Reads

Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene.

Open Med (Wars) 2019 24;14:1-9. Epub 2018 Dec 24.

Key Laboratory of Contraceptive Drugs and Devices of NPFPC, Shanghai Institute of Planned Parenthood Research, Shanghai, China.

Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2019-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310915PMC
December 2018

Combination of Novoseven and Feiba in Hemophiliac Patients with Inhibitors.

Open Med (Wars) 2018 24;13:618-621. Epub 2018 Dec 24.

Hacettepe University, School of Medicine, Department of Hematology, TR-06100, Ankara, Turkey.

The aim of this study is to investigate the effective therapeutic combination of recombinant VIIa(Novoseven) and factor eight inhibitor bypass activity(FEIBA) drugs for the bleedings of adult hemophiliac patients with inhibitors.19 bleeding episodes of 5 hemophilia A patients who were using bypassing agents and followed-up between 2008 and 2016 in Hacettepe Hematology Department were analyzed retrospectively. In 11, 5 and 3 bleeding episodes, FEIBA, recombinant factor VIIa and FEIBA+recombinant factor VIIa were given to the patients, respectively. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/med.2018.13.issue-1/med-2018
Publisher Site
http://dx.doi.org/10.1515/med-2018-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310920PMC
December 2018
9 Reads

Plastic Treatment for Giant Pseudocyst after Incisional Hernia Mesh Repair: A Case Report and Comprehensive Literature Review.

Open Med (Wars) 2018 24;13:539-543. Epub 2018 Dec 24.

Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius Lithuania.

Giant pseudocyst is a very rare complication after incisional hernia repair with mesh. We present a case of 54-year-old male patient with a giant pseudocyst, which developed after incisional hernia repair with mesh. A patient was discussed during multidisciplinary team meeting and operative treatment was suggested to the patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2018-0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310916PMC
December 2018
1 Read

Serum Tumor Marker Carbohydrate Antigen 125 Levels and Carotid Atherosclerosis in Patients with Coronary Artery Disease.

Open Med (Wars) 2018 24;13:534-538. Epub 2018 Dec 24.

Laboratory Medicine Diagnostic Center, The First Affiliated Hospital, Xinjiang Medical University, No. 137, Liyushan Road, Xin'shi Region, Urumqi, Xinjiang 830011, China.

Objective: We assessed the correlation between serum carbohydrate antigen 125 (CA125) and carotid intima-media thickness (cIMT) in patients with coronary artery disease (CAD).

Methods: We collected 518 CAD patients from the cardiovascular disease center in our hospital, and all cIMT values were measured in patients with CAD.

Results: The serum CA125 concentrations were found to be increased in CAD patients with early carotid atherosclerosis compared with patients without early carotid atherosclerosis (20. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/med.2018.13.issue-1/med-2018
Publisher Site
http://dx.doi.org/10.1515/med-2018-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310918PMC
December 2018
1 Read

MDA-19 Suppresses Progression of Melanoma Via Inhibiting the PI3K/Akt Pathway.

Open Med (Wars) 2018 16;13:416-424. Epub 2018 Dec 16.

Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Shandong University, Jinan 250012, Shandong Province, P.R. China.

Objective: To investigate the effect of MDA-19 on progression of melanoma, and explore the relevant mechanism.

Methods: The melanoma cell lines, M14 and UACC257, were treated with different concentrations of MDA-19, then CCK8, clone formation assay, Transwell and flow cytometry assays were performed to examine cell proliferation, migration, invasion and apoptosis, respectively. The expression of apoptosis-related proteins (Bcl-2, Bax and caspase 3 P17), EMT and signaling pathway-related proteins were also detected by Western blot. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/med.2018.13.issue-1/med-2018
Publisher Site
http://dx.doi.org/10.1515/med-2018-0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310917PMC
December 2018
4 Reads

Reaching out to diabetic soles: Outreach foot care pilot project.

SAGE Open Med 2018 17;6:2050312118820030. Epub 2018 Dec 17.

Fredericton Downtown Community Health Centre, Fredericton, NB, Canada.

Objectives: To assess the effectiveness of outreach foot care services as a tool for engagement with isolated vulnerable seniors. To improve foot health of diabetic seniors, thus avoiding expensive and potentially life-threatening diabetic complications.

Methods: Four validated tools are used to gather data: InLow 60-second Diabetic Foot Screen©, Short Diabetes Knowledge Instrument for Older and Minority Adults, Brief Healthcare Questionnaire (Patient Health Questionnaire-9), and the Health-Related Quality of Life Questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118820030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299298PMC
December 2018

Improving spatial working memory in blind and sighted youngsters using programmable tactile displays.

SAGE Open Med 2018 18;6:2050312118820028. Epub 2018 Dec 18.

Robotics, Brain and Cognitive Sciences department, Center for Human Technologies, Istituto Italiano di Tecnologia, Genoa, Italy.

Objective: To investigate whether training with tactile matrices displayed with a programmable tactile display improves recalling performance of spatial images in blind, low-vision and sighted youngsters. To code and understand the behavioral underpinnings of learning two-dimensional tactile dispositions, in terms of spontaneous exploration strategies.

Methods: Three groups of blind, low-vision and sighted youngsters between 6 and 18 years old performed four training sessions with a weekly schedule in which they were asked to memorize single or double spatial layouts, featured as two-dimensional matrices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118820028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299321PMC
December 2018

Explicit and implicit experience of own's body in painful musculoskeletal disorders and rheumatic diseases: A scoping review protocol of available quantitative and qualitative evidence.

SAGE Open Med 2018 18;6:2050312118820026. Epub 2018 Dec 18.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Campus of Savona, Savona, Italy.

Introduction: Our body experience is organized at twofold levels: perceptual and cognitive-emotional. These higher-order processes are clearly different from the primary sensory processing of somatic stimuli (somatosensation). However, most of the available studies have mainly investigated the mechanisms of somatosensation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118820026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299299PMC
December 2018

The BODE index and inspiratory muscle performance in COPD: Clinical findings and implications.

SAGE Open Med 2018 12;6:2050312118819015. Epub 2018 Dec 12.

Pulmonary Section, Miami Veterans Administration Medical Center, Miami, FL, USA.

Objectives: The Test of Incremental Respiratory Endurance is a novel testing method that provides a unique examination of one's inspiratory muscle strength, work and endurance. Little is known about the relationship between inspiratory muscle performance and mortality risk in obstructive lung disease. We examined the relationship between the Test of Incremental Respiratory Endurance measures and the Body-mass index, airflow Obstruction, Dyspnea and Exercise index in chronic obstructive pulmonary disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118819015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295678PMC
December 2018
1 Read

Amifampridine phosphate in the treatment of muscle-specific kinase myasthenia gravis: a phase IIb, randomized, double-blind, placebo-controlled, double crossover study.

SAGE Open Med 2018 17;6:2050312118819013. Epub 2018 Dec 17.

Department of Neuroimmunology and Neuromuscular Diseases, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (INCB), Milan, Italy.

Objective: The aim of this study is to determine the safety and the efficacy of amifampridine phosphate in muscle-specific kinase antibody-positive myasthenia gravis, in a 1:1 randomized, double-blind, placebo-controlled, switchback, double crossover study.

Methods: Eligible patients had muscle-specific kinase myasthenia gravis, >18 years of age, and Myasthenia Gravis Foundation of America class II-IV with a score of ⩾9 on Myasthenia Gravis Composite scale. After the run-in phase, during which amifampridine phosphate was titrated to a tolerable and effective dosage, patients were randomized to receive placebo-amifampridine-placebo sequence or amifampridine-placebo-amifampridine sequence daily for 7 days. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2050312118819013
Publisher Site
http://dx.doi.org/10.1177/2050312118819013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299310PMC
December 2018
4 Reads

Satisfaction of surgical patients with perioperative nursing care in a Spanish tertiary care hospital.

SAGE Open Med 2018 10;6:2050312118818304. Epub 2018 Dec 10.

Department of Nursing Research and Education, Hospital Clinic of Barcelona, Barcelona, Spain.

Objective: Although numerous studies have assessed patient satisfaction in diverse settings, in the realm of nursing surgical care, standardization of measurement for patient experience and satisfaction is lacking. Therefore, the aim of this study was to assess the satisfaction of surgical patients with perioperative nursing care.

Method: A descriptive cross-sectional survey was conducted. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2050312118818304
Publisher Site
http://dx.doi.org/10.1177/2050312118818304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295759PMC
December 2018
1 Read

Home-based exercise programmes for individuals with intermittent claudication: A protocol for an updated systematic review and meta-analysis.

SAGE Open Med 2018 10;6:2050312118818295. Epub 2018 Dec 10.

Academic Vascular Surgical Unit, Hull, UK.

Background: The aim of this updated review is to consider the evidence base for the effectiveness of home-based exercise programmes as a treatment option for improving walking distance in patients with intermittent claudication.

Methods: The Medline, EMBASE, CINAHL, PEDro and Cochrane CENTRAL databases will be searched for terms including 'intermittent claudication', 'peripheral arterial disease', 'home-based exercise' and 'home-based walking'. No date restrictions will be used but only articles in the English language will be included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118818295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295772PMC
December 2018

Detection of neuraminidase inhibitor-resistant influenza A (H1N1)pdm09 viruses obtained from influenza surveillance in Indonesia.

SAGE Open Med 2018 10;6:2050312118818293. Epub 2018 Dec 10.

National Institute of Health Research Development, Ministry of Health, Jakarta, Republic of Indonesia.

Background: Influenza antiviral resistance has been shown to occur in many countries and is commonly found in influenza A(H1N1)pdm09 and A(H3N2). In this study, we monitored and investigated the neuraminidase inhibitor resistance of influenza A(H1N1)pdm09 viruses through the influenza surveillance system in Indonesia.

Methods: A total of 4752 clinical specimens were collected from patients with influenza-like illness and severe acute respiratory infection during the year 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118818293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295675PMC
December 2018
1 Read

Participants and developers experiences with a chronic pain self-management intervention under development: A qualitative study.

SAGE Open Med 2018 4;6:2050312118817427. Epub 2018 Dec 4.

Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

Background: Non-pharmacological interventions aim to promote health and self-management for people with chronic pain.

Objective: The aim of this study was to explore if the participants' experiences with a self-management intervention under development were aligned with the developers' rationale and desired outcome of the intervention.

Methods: This was a qualitative study interviewing both participants and developers of a chronic pain self-management intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312118817427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295746PMC
December 2018

HIV virologic response better with single-tablet once daily regimens compared to multiple-tablet daily regimens.

SAGE Open Med 2018 4;6:2050312118816919. Epub 2018 Dec 4.

West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, WV, USA.

Background: Single-tablet regimens are preferred prescription choices for HIV treatment, but there are limited outcomes data comparing single-tablet regimens to multiple-tablet regimens.

Methods: We retrospectively assessed treatment-naïve patients at a single urban HIV clinic in the United States for viral load suppression at 6 and 12 months after initiating either single-tablet or multiple-tablet regimens. Multivariate regression was performed to obtain relative risks and adjust for potential confounders. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2050312118816919
Publisher Site
http://dx.doi.org/10.1177/2050312118816919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295695PMC
December 2018
2 Reads

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling.

SAGE Open Med 2018 4;6:2050312118813283. Epub 2018 Dec 4.

Monash Emergency Research Collaborative, Department of Emergency Medicine, Dandenong Hospital, Monash Health, Dandenong, VIC, Australia.

Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol. Intranasal drug administration reduces need for intravenous line placement and risk of needle-stick. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2050312118813283
Publisher Site
http://dx.doi.org/10.1177/2050312118813283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295742PMC
December 2018
3 Reads

The Effects of Gastrointestinal Function on the Incidence of Ventilator-associated Pneumonia in Critically Ill Patients.

Open Med (Wars) 2018 6;13:556-561. Epub 2018 Dec 6.

Department of ultrasonography, China-Japan union Hospital, Jilin University, Changchun, Jilin 130033, China.

Objective: To investigate the effect of gastrointestinal function on the incidence of ventilator-associated pneumonia (VAP) in critically ill patients.

Methods: From August 2012 to June 2016, 160 critically ill patients in the ICU (Intensive Care Unit) of our hospital were selected as the research group; patients were divided equally into an observation group and a control group, 80 patients in each group, based on the random draw envelope principle. The control group was given a nasogastric tube for gastric feeding, the observation group was given a dual lumen gastrointestinal enteral device for gastric feeding; the two groups' enteral nutrition observation time was 7d; any changes in patient condition and prognosis were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2018-0082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287170PMC
December 2018
2 Reads

CD5 and CD43 Expression are Associate with Poor Prognosis in DLBCL Patients.

Open Med (Wars) 2018 27;13:605-609. Epub 2018 Nov 27.

Department of Internal Medicine 5th Division Jiangxi Cancer Center, Jiangxi Cancer Hospital, Nanchang University, Nanchang, 330029 P.R. China.

Objective: To investigate the expression and clinical significance of CD5 and CD43 in diffuse large B cell lymphoma (DLBCL) (unspecified).

Methods: Sixty - five patients with diagnosed DLBCL were enrolled. The expressions of CD5, CD43, CD10, Bcl-6 and Mun-1 were detected by immuno histochemistry. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/med.2018.13.issue-1/med-2018
Publisher Site
http://dx.doi.org/10.1515/med-2018-0089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272054PMC
November 2018
26 Reads

Henoch-schonlein Purpura Nephritis with Renal Interstitial Lesions.

Open Med (Wars) 2018 27;13:597-604. Epub 2018 Nov 27.

Institute of Pathology, Basic Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Objective: To investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions.

Methods: All 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2018-0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272053PMC
November 2018
4 Reads