3 results match your criteria Open Journal of Rheumatology and Autoimmune Diseases

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Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.

Open J Rheumatol Autoimmune Dis 2014 Feb;4(1):62-68

Department of Pediatrics, Program in immunology, Stanford University Medical Center, Stanford, CA-94305.

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and progressive cartilage and bone destruction that leads to a substantial loss of general functions and/or a decline in physical activities such as walking speed in humans. The K/BxN serum transfer arthritis in mice shares many immunological and pathological features with human RA. Very few studies are available in mice that investigate the changes in physical activity in relation to arthritis development. Read More

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http://dx.doi.org/10.4236/ojra.2014.41010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264968PMC
February 2014
18 Reads

Magnetic Resonance Elastography for Liver Fibrosis in Methotrexate Treatment.

Open J Rheumatol Autoimmune Dis 2012 May;2(2):6-13

Division of Rheumatology, Mayo Clinic, Rochester ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.

Introduction: Hepatic magnetic resonance elastography (MRE) allows for noninvasive assessment of liver fibrosis. The purpose of this study was to evaluate the usefulness of MRE in detecting and quantifying liver fibrosis in patients with rheumatoid arthritis (RA) who have received methotrexate (MTX).

Methods: The association between mean liver stiffness value as determined by MRE and variables of interest was determined. Read More

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http://dx.doi.org/10.4236/ojra.2012.22003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562680PMC
May 2012
16 Reads

TNF- Antagonist and Infection in Rheumatoid Arthritis.

Open J Rheumatol Autoimmune Dis 2012 May;2(2):14-20

Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, USA.

Background: Anti-TNF treatment may increase infection risk, although this has been difficult to study because the timing of anti-TNF treatment is driven by disease activity, which may influence infection susceptibility leading to confounding that varies over time. We evaluated the association between anti-TNF initiation in rheumatoid arthritis (RA) patients on disease modifying anti-rheumatic drugs (DMARD) and infection using multiple approaches adjusting for time-varying confounding.

Methods: 383 anti-TNF-naïve RA patients on ≥1 non-biologic-DMARD at enrollment from the Brigham and Women's Rheumatoid Arthritis Sequential Study (BRASS) were followed up to two years. Read More

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http://dx.doi.org/10.4236/ojra.2012.22004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089359PMC
May 2012
23 Reads
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