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Open J Mol Integr Physiol 2016 Aug 22;6(3):35-43. Epub 2016 Aug 22.

Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Institute of Medical Biophysics.

The modulation of mechanically induced tracheobronchial cough was tested by applying various stimuli and the elicitation of other airway protective behaviors in pentobarbital anesthetized cats. Capsaicin and histamine were injected in the nose, and mechanical nylon fiber and / or air puff stimulation was applied to the nose and nasopharynx. Reflex responses of cough, sneeze, aspiration reflex and expiration reflex were induced mechanically. Read More

Open J Mol Integr Physiol 2013 Nov;3(4):166-180

Pediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O, 90% N) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (V) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i. Read More

Open J Mol Integr Physiol 2013 Aug;3(3):134-145

Pediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

This study explored the concept that morphine has latent deleterious actions on the ventilatory control systems that respond to a hypoxic-hypercapnic challenge. In this study, we examined the ventilatory responses elicited by hypoxic-hypercapnic challenge in conscious rats at a time when the effects of morphine (10 mg/kg) on arterial blood-gas chemistry and minute ventilation had subsided. Morphine induced pronounced changes in arterial blood-gas chemistry (e. Read More

Open J Mol Integr Physiol 2013 Aug;3(3):111-124

Pediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

The systemic administration of morphine affects ventilation via a mixture of central and peripheral actions. The aims of this study were to characterize the ventilatory responses elicited by a low dose of morphine in conscious rats; to determine whether tolerance develops to these responses; and to determine the potential roles of peripheral μ-opioid receptors (μ-ORs) in these responses. Ventilatory parameters were monitored via unrestrained whole-body plethysmography. Read More