Open J Mol Integr Physiol 2013 Nov;3(4):166-180
Pediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O, 90% N) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (V) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i. Read More