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Open J Med Psychol 2014 Apr;3(3):202-211

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13 Street, Charlestown, Massachusetts 02129, USA.

Many studies have reported long-term modulation of metabotropic glutamate receptor 5 (mGluR5) by inflammatory processes and a pharmacological modulation of mGluR5 is known to regulate anxiety level. However, it is not known if non-pharmacological modulation of mGluR5 by inflammation impaired the unconditional level of anxiety. In this study, we investigated this relation in LPS prenatal immune challenge (120μg/kg, 3x i. Read More

Open J Med Psychol 2012 Jan;1(1):1-7

DePaul University.

OBJECTIVES: We combine Hobfoll's Conservation of Resources (COR) theory and key components of self-help group "step work" ideology to investigate how dynamic changes in key intra-individual resource loss and gains (self-esteem, abstinence self-efficacy, existential growth) influence relapse rates in a sample of individuals in the Maintenance Stage of substance abuse recovery. METHODS: Participants (n = 579) completed two surveys over a nine month period that assessed baseline and changes in intra-individual loss and gain resources as well as relapse rates over study course. Multiple regression analyses were performed to predict whether baseline and dynamic changes in intra-individual scores predict relapse rates over time. Read More

Open J Med Psychol 2013 Jan;2(1):23-28

Department of Psychiatry and Behavioral Medicine, Duke Medical Center, Durham, USA.

The chronic stress of caregiving has been associated with increased risk for cognitive decline and dementia. One theoretical model suggests that a group of risk factors known as the metabolic syndrome MET_SYN (e.g. Read More

Anesth Analg 2007 Jun;104(6):1570-7, table of contents

Department of Anesthesiology, Osaka University Medical School, Suita, Osaka, Japan.

Background: Patients with chronic pain frequently suffer affective disorders, particularly anxiety and depression. Although clinical research on the relationship between pain and depressive symptoms has been done, it is not clear whether pain causes depression or depression exaggerates pain. To investigate the relation between pain and affect, we measured anxiety and depression-related behaviors in mice after spinal nerve ligation using classical behavioral tests. Read More