600,464 results match your criteria Open Journal of Immunology


Electrical Stimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study.

Stereotact Funct Neurosurg 2020 Oct 28:1-8. Epub 2020 Oct 28.

Unit of Functional Neurosurgery, Stereotaxy and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico,

Introduction: Evidence has been provided that the subiculum may play an important role in the generation of seizures. Electrical stimulation at this target has been reported to have anticonvulsive effects in kindling and pilocarpine rat models, while in a clinical study of hippocampal deep brain stimulation (DBS), contacts closest to the subiculum were associated with a better anticonvulsive effect.

Objectives: To evaluate the effect of electrical stimulation of the subiculum in patients with refractory mesial temporal lobe epilepsy (MTLE) who have hippocampal sclerosis (HS). Read More

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http://dx.doi.org/10.1159/000510295DOI Listing
October 2020

Unveiling the Interplay between Induced Native Defects and Room Temperature Magnetic Ordering in Titanium Deficient Disordered-TiONanoparticles.

Nanotechnology 2020 Oct 28. Epub 2020 Oct 28.

Nanosensor Laboratory , PSG Institute of Advanced Studies, Nanosensor Laboratory (NSL),, PSG Institute of Advanced Studies,, Coimbatore-641004, coimbatore, Tamilnadu, 641004, INDIA.

Understanding the origin of magnetic ordering in an undoped semiconductor with native defects is an open question, which is being explored actively in research. In this investigation, the interplay between magnetic ordering and excess induced native defects in undoped anatase TiOnanoparticles is explained using an experimental and theoretical approach. It is demonstrated that structurally disordered TiOnanoparticles with a high concentration of native defects such as titanium interstitials and oxygen vacancies are synthesised using controlled atmospheric rapid cooling (i. Read More

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http://dx.doi.org/10.1088/1361-6528/abc57bDOI Listing
October 2020

Glaucoma as a prognostic factor of central retinal vein occlusion: visual and anatomical outcomes and occurrence of ischaemic central retinal vein occlusion.

Acta Ophthalmol 2020 Oct 28. Epub 2020 Oct 28.

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To compare the functional and anatomical outcomes of central retinal vein occlusion (CRVO) according to the presence of glaucoma before the onset of CRVO, and to assess whether pre-existing glaucoma affects the prognosis of CRVO in terms of development and conversion to ischaemic CRVO.

Methods: In this retrospective cohort study, patients with treatment-naïve CRVO were enrolled between December 2009 and February 2019. The patients were classified into two groups according to the presence of pre-existing primary open-angle glaucoma at CRVO diagnosis. Read More

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http://dx.doi.org/10.1111/aos.14608DOI Listing
October 2020

A novel workflow to improve genotyping of multigene families in wildlife species: an experimental set-up with a known model system.

Mol Ecol Resour 2020 Oct 28. Epub 2020 Oct 28.

Institute of Evolutionary Ecology and Conservation Genomics, Ulm Universität, Ulm, Germany.

Genotyping complex multigene families in novel systems is particularly challenging. Target primers frequently amplify simultaneously multiple loci leading to high PCR and sequencing artefacts such as chimeras and allele amplification bias. Most genotyping pipelines have been validated in non-model systems whereby the real genotype is unknown and the generation of artefacts may be highly repeatable. Read More

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http://dx.doi.org/10.1111/1755-0998.13290DOI Listing
October 2020

Genome-wide DNA methylation analysis of Hashimoto's thyroiditis during pregnancy.

FEBS Open Bio 2020 Oct 28. Epub 2020 Oct 28.

Eugenic Genetics Laboratory, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Hubei Province, Wuhan, 430016, China.

Hashimoto's thyroiditis (HT) during pregnancy is usually accompanied by an elevation of thyroid-stimulating hormone and a reduction of serum free thyroxine during gestation, which may lead to abortion, preterm delivery, and reduced intellectual function of the offspring. Epigenetic alterations may provide important insights into genetic-environmental interactions in HT. Here, we examined global DNA methylation patterns in patients with HT during pregnancy. Read More

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http://dx.doi.org/10.1002/2211-5463.13018DOI Listing
October 2020

Clinical Issues-November 2020.

Authors:
Kristyn Seeman

AORN J 2020 Nov;112(5):568-574

Using adhesive tape for patient positioning Key words: adhesive tape, surgical tape, patient positioning, pressure injury, contamination. Border sterility of open sterile wrappers Key words: wrapped sterile item, unsterile border, wrapper flap, contaminated, aseptic technique. Cost per minute of OR time Key words: cost comparison, direct costs, cost savings, perioperative efficiency, product evaluation. Read More

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http://dx.doi.org/10.1002/aorn.13238DOI Listing
November 2020

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics.

Clin Pharmacol Ther 2020 Oct 28. Epub 2020 Oct 28.

Centre for Applied Pharmacokinetic Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

The intestinal epithelium represents a natural barrier against harmful xenobiotics, whilst facilitating the uptake of nutrients and other substances. Understanding the interaction of chemicals with constituents of the intestinal epithelium and their fate in the body requires quantitative measurement of relevant proteins in in vitro systems and intestinal epithelium. Recent studies have highlighted the mismatch between mRNA and protein abundance for several drug-metabolising enzymes and transporters in the highly dynamic environment of the intestinal epithelium; mRNA abundances cannot therefore be used as a proxy for protein abundances in the gut, necessitating direct measurements. Read More

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http://dx.doi.org/10.1002/cpt.2097DOI Listing
October 2020

Robotic-assisted pulley technique for the ventral hernia.

J Robot Surg 2020 Oct 28. Epub 2020 Oct 28.

Department of Surgery, Abington Jefferson Health, 1200 Old York Road, Abington, PA, 19001, USA.

When approaching complex abdominal wall hernias at either index operation or a subsequent reoperation for recurrent incarcerated abdominal wall hernias, a majority of surgeons consider mesh placement a key step in the prevention of a future recurrence. While the laparoscopic and open approaches show no significant difference in hernia recurrence, the laparoscopic approach to complex abdominal wall hernias does reduce surgical-site infection, postoperative ileus, improves short-term quality-of-life scores, and reduces hospital length of stay (Davies et al. in Am Surg 78(8):888-892, https://www. Read More

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http://dx.doi.org/10.1007/s11701-020-01161-9DOI Listing
October 2020

Correction to: Glomerulosclerosis predicts poor renal outcome in patients with idiopathic membranous nephropathy.

Int Urol Nephrol 2020 Oct 28. Epub 2020 Oct 28.

Department of Applied Statistics, School of Applied Mathematics, Guangdong University of Technology, Guangzhou, 510643, China.

The article 'Glomerulosclerosis predicts poor renal outcome in patients with idiopathic membranous nephropathy', written by Cuimei Wei, Yongcheng He, Tong Li, Haofei Hu, Haiying Song, Dongli Qi, Yuan Cheng, Jia Chen, Mijie Guan, Xiaohua Xiao, Junyi Li, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 22 September 2020 with open access. Read More

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http://dx.doi.org/10.1007/s11255-020-02675-9DOI Listing
October 2020

Promoting adsorption of organic pollutants via tailoring surface physicochemical properties of biomass-derived carbon-attapulgite.

Environ Sci Pollut Res Int 2020 Oct 28. Epub 2020 Oct 28.

Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Jiangsu Province Key Laboratory of Environmental Engineering, Nanjing, 210096, Jiangsu, China.

Biomass-derived carbon-attapulgite adsorbent was developed for organic pollutants removal. All the batch assays were performed to evaluate the effects of organic components, contact time, and initial concentration of organic pollutants on the adsorption performance of the as-prepared adsorbent. The samples were characterized via Brunauer-Emmett-Teller (BET), Fourier transform infrared (FTIR), X-ray diffractometer (XRD), and scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.1007/s11356-020-10974-yDOI Listing
October 2020

Wayfinding: How Ecological Perspectives of Navigating Dynamic Environments Can Enrich Our Understanding of the Learner and the Learning Process in Sport.

Sports Med Open 2020 Oct 28;6(1):51. Epub 2020 Oct 28.

Sport & Human Performance Research Group, Sheffield Hallam University, Sheffield, UK.

Wayfinding is the process of embarking upon a purposeful, intentional, and self-regulated journey that takes an individual from an intended region in one landscape to another. This process is facilitated through an individual's capacity to utilise temporally structured, functional actions embedded within a particular environmental niche. Thus, individuals learn of their performance landscapes by experiencing them through interactions, detecting and exploiting its many features to 'find their way'. Read More

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http://dx.doi.org/10.1186/s40798-020-00280-9DOI Listing
October 2020

Severity and predictors of head injury due to bicycle accidents in Western Australia.

Acta Neurochir (Wien) 2020 Oct 28. Epub 2020 Oct 28.

Department of Orthopaedics and Trauma Surgery, Royal Perth Hospital, Perth, Western Australia, Australia.

Background: Head and face injuries are the second most frequently reported injuries among bicyclists. Recently, helmet usage has increased, and in some countries, helmet laws have been introduced. However, subsequent changes in the incidence and severity of traumatic brain injury (TBI) are unknown, and data on neurosurgical interventions are lacking. Read More

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http://dx.doi.org/10.1007/s00701-020-04626-wDOI Listing
October 2020

Alcohol metabolite acetic acid activates BK channels in a pH-dependent manner and decreases calcium oscillations and exocytosis of secretory granules in rat pituitary GH3 cells.

Pflugers Arch 2020 Oct 28. Epub 2020 Oct 28.

Department of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya str. 18, Kazan, 420008, Russia.

Acetaldehyde and acetic acid/acetate, the active metabolites of alcohol (ethanol, EtOH), generate actions of their own ranging from behavioral, physiological, to pathological/cancerogenic effects. EtOH and acetaldehyde have been studied to some depth, whereas the effects of acetic acid have been less well explored. In this study, we investigated the effect of acetic acid on big conductance calcium-activated potassium (BK) channels present in GH3 rat pituitary tumor cells in more detail. Read More

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http://dx.doi.org/10.1007/s00424-020-02484-0DOI Listing
October 2020

Use of cryoanalgesia as a postoperative pain management for open pectus carinatum repair.

Pediatr Surg Int 2020 Oct 28. Epub 2020 Oct 28.

Division of Pediatric Surgery, University of California San Francisco, San Francisco, USA.

Purpose: Cryoanalgesia has shown to have safety and efficacy as an adjunct post-operative pain management for Nuss procedure. One retrospective study reported its efficacy for analgesia with the Ravitch procedure, with improved pain scores and decreased length of stay versus thoracic epidural. We describe our initial experience with the use of cryoanalgesia for an open repair of pectus carinatum. Read More

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http://dx.doi.org/10.1007/s00383-020-04768-zDOI Listing
October 2020

Advanced non-noble materials in bifunctional catalysts for ORR and OER toward aqueous metal-air batteries.

Nanoscale 2020 Oct 28. Epub 2020 Oct 28.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, State Key Lab of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150001, China.

The catalyst in the oxygen electrode is the core component of the aqueous metal-air battery, which plays a vital role in the determination of the open circuit potential, energy density, and cycle life of the battery. For rechargeable aqueous metal-air batteries, the catalyst should have both good oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic performance. Compared with precious metal catalysts, non-precious metal materials have more advantages in terms of abundant resource reserves and low prices. Read More

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http://dx.doi.org/10.1039/d0nr05511eDOI Listing
October 2020

Assesment of the QuickSee wavefront autorefractor for characterizing refractive errors in school-age children.

PLoS One 2020 28;15(10):e0240933. Epub 2020 Oct 28.

Department of Electronics and Communications Technology, Universidad Autónoma de Madrid, Madrid, Spain.

Purpose: To assess the performance of an open-view binocular handheld aberrometer (QuickSee) for diagnosing refractive errors in children.

Methods: 123 school-age children (9.9 ± 3. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240933PLOS
October 2020

Central venous pressure estimation from ultrasound assessment of the jugular venous pulse.

PLoS One 2020 28;15(10):e0240057. Epub 2020 Oct 28.

Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, United Kingdom.

Objectives: Acquiring central venous pressure (CVP), an important clinical parameter, requires an invasive procedure, which poses risk to patients. The aim of the study was to develop a non-invasive methodology for determining mean-CVP from ultrasound assessment of the jugular venous pulse.

Methods: In thirty-four adult patients (age = 60 ± 12 years; 10 males), CVP was measured using a central venous catheter, with internal jugular vein (IJV) cross-sectional area (CSA) variation along the cardiac beat acquired using ultrasound. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240057PLOS
October 2020

Membrane thinning and lateral gating are consistent features of BamA across multiple species.

PLoS Comput Biol 2020 Oct 28;16(10):e1008355. Epub 2020 Oct 28.

School of Physics, Georgia Institute of Technology, Atlanta, Georgia, United States of America.

In Gram-negative bacteria, the folding and insertion of β-barrel outer membrane proteins (OMPs) to the outer membrane are mediated by the β-barrel assembly machinery (BAM) complex. Two leading models of this process have been put forth: the hybrid barrel model, which claims that a lateral gate in BamA's β-barrel can serve as a template for incoming OMPs, and the passive model, which claims that a thinned membrane near the lateral gate of BamA accelerates spontaneous OMP insertion. To examine the key elements of these two models, we have carried out 45. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1008355DOI Listing
October 2020

HIF2α supports pro-metastatic behavior in pheochromocytomas/paragangliomas.

Endocr Relat Cancer 2020 Nov;27(11):625-640

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany.

Mutations that drive the stabilization of hypoxia inducible factor 2α (HIF2α) and downstream pseudohypoxic signaling are known to predispose to the development of pheochromocytomas and paragangliomas (PPGLs). However, any role of HIF2α in predisposition to metastatic disease remains unclear. To assess such a role we combined gene-manipulations in pheochromocytoma cell lines with retrospective analyses of patient data and gene expression profiling in tumor specimens. Read More

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http://dx.doi.org/10.1530/ERC-20-0205DOI Listing
November 2020

Maternal adaptations of pancreatic islets and glucose metabolism after lactation.

J Endocrinol 2020 Oct 1. Epub 2020 Oct 1.

C Fernandez-Mejia, Unidad de Genética de la Nutrición, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.

Pancreatic islets adapt to metabolic requirements and the hormonal milieu by modifying their size and hormone secretions. Maternal glucose demands and hormonal changes occur after weaning, to rapidly re-establish bone mineralization. Minimal information exists about glucose metabolism and pancreatic islets after lactation. Read More

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http://dx.doi.org/10.1530/JOE-20-0184DOI Listing
October 2020

The basal ganglia corticostriatal loops and conditional learning.

Authors:
Keyvan Yahya

Rev Neurosci 2020 Oct 28. Epub 2020 Oct 28.

Chemnitz University of Technology, Computer, straße der Nation , 62, 09111, Chemnitz, Germany.

Brief maneuvering of the literature as to the various roles attributed to the basal ganglia corticostriatal circuits in a variety of cognitive processes such as working memory, selective attention, and category learning has inspired us to investigate the interplay of the two major basal ganglia open-recurrent loops, namely, visual and executive loops specifically the possible involvement of their overlap in conditional learning. We propose that the interaction of the visual and executive loops reflected through their cortical overlap in the dorsolateral prefrontal cortex (DL-PFC), lateral orbitofrontal cortex (LO-PFC), and presupplementary motor area (SMA) plays an instrumental role preliminary first in forming associations between a series of correct responses following similar stimuli and then in shifting, abstracting, and generalizing conditioned responses. The premotor and supplementary motor areas have been shown essential to producing a sequence of movements while the SMA is engaged in monitoring complex movements. Read More

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http://dx.doi.org/10.1515/revneuro-2020-0047DOI Listing
October 2020

Toward a Reinforcement Learning Environment Toolbox for Intelligent Electric Motor Control.

IEEE Trans Neural Netw Learn Syst 2020 Oct 28;PP. Epub 2020 Oct 28.

Electric motors are used in many applications, and their efficiency is strongly dependent on their control. Among others, linear feedback approaches or model predictive control methods are well known in the scientific literature and industrial practice. A novel approach is to use reinforcement learning (RL) to have an agent learn electric drive control from scratch merely by interacting with a suitable control environment. Read More

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http://dx.doi.org/10.1109/TNNLS.2020.3029573DOI Listing
October 2020

Task Similarity Estimation Through Adversarial Multitask Neural Network.

IEEE Trans Neural Netw Learn Syst 2020 Oct 28;PP. Epub 2020 Oct 28.

Multitask learning (MTL) aims at solving the related tasks simultaneously by exploiting shared knowledge to improve performance on individual tasks. Though numerous empirical results supported the notion that such shared knowledge among tasks plays an essential role in MTL, the theoretical understanding of the relationships between tasks and their impact on learning shared knowledge is still an open problem. In this work, we are developing a theoretical perspective of the benefits involved in using information similarity for MTL. Read More

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http://dx.doi.org/10.1109/TNNLS.2020.3028022DOI Listing
October 2020

Under what circumstances can immigrant patients and healthcare professionals co-produce health? - an interpretive scoping review.

Int J Qual Stud Health Well-being 2020 Dec;15(1):1838052

Direction générale de la santé, Unisanté , Lausanne, Switzerland.

Purpose: Immigrant patients run a risk of receiving lower quality of care. Co-production, as the concept of how to collaboratively create valuable healthcare service for the patient, offers a new perspective that might help. The scoping review aimed at identifying and analysing factors facilitating co-production between immigrant patients and healthcare professionals. Read More

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http://dx.doi.org/10.1080/17482631.2020.1838052DOI Listing
December 2020

LncRBase V.2: an updated resource for multispecies lncRNAs and ClinicLSNP hosting genetic variants in lncRNAs for cancer patients.

RNA Biol 2020 Oct 28:1-16. Epub 2020 Oct 28.

Division of Bioinformatics, Bose Institute , Kolkata, India.

The recent discovery of long non-coding RNA as a regulatory molecule in the cellular system has altered the concept of the functional aptitude of the genome. Since our publication of the first version of LncRBase in 2014, there has been an enormous increase in the number of annotated lncRNAs of multiple species other than Human and Mouse. LncRBase V. Read More

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http://dx.doi.org/10.1080/15476286.2020.1833529DOI Listing
October 2020

A Solution to Academic Radiology's Experience With Solicitation E-mails From Predatory Journals.

AJR Am J Roentgenol 2020 Oct 28:1-8. Epub 2020 Oct 28.

Division of Vascular and Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287.

The objective of our study was to help academic researchers avoid predatory publishers by characterizing the problem with respect to radiology and medical imaging and to test an intervention to address aggressive e-mail solicitation. In total, 803 faculty from 10 U.S. Read More

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http://dx.doi.org/10.2214/AJR.20.22923DOI Listing
October 2020

Integration of Simultaneous Resting-State Electroencephalography, Functional Magnetic Resonance Imaging, and Eye-Tracker Methods to Determine and Verify Electroencephalography Vigilance Measure.

Brain Connect 2020 Oct 28. Epub 2020 Oct 28.

Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.

Concurrent electroencephalography and resting-state functional magnetic resonance imaging (rsfMRI) have been widely used for studying the (presumably) awake and alert human brain with high temporal/spatial resolution. Although rsfMRI scans are typically collected while individuals are instructed to focus their eyes on a fixated cross, objective and verified experimental measures to quantify degree of vigilance are not readily available. Electroencephalography (EEG) is the modality extensively used for estimating vigilance, especially during eyes-closed resting state. Read More

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http://dx.doi.org/10.1089/brain.2019.0731DOI Listing
October 2020

Simulating Multiple Substrate-Binding Events by γ-Glutamyltransferase Using Accelerated Molecular Dynamics.

J Phys Chem B 2020 Oct 28. Epub 2020 Oct 28.

Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus, Denmark.

γ-Glutamyltransferase (GGT) is an enzyme that uses γ-glutamyl compounds as substrates and catalyzes their transfer to a water molecule or an acceptor substrate with varied physiological function in bacteria, plants, and animals. Crystal structures of GGT are known for different species and in different states of the chemical reaction; however, the structural dynamics of the substrate binding to the catalytic site of GGT are unknown. Here, we modeled GGT's glutamine binding by using a swarm of accelerated molecular dynamics (aMD) simulations. Read More

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http://dx.doi.org/10.1021/acs.jpcb.0c06907DOI Listing
October 2020

Enhancing Open-Circuit Voltage of High-Efficiency Nonfullerene Ternary Solar Cells with a Star-Shaped Acceptor.

ACS Appl Mater Interfaces 2020 Oct 28. Epub 2020 Oct 28.

Department of Physics, The Chinese University of Hong Kong, New Territories 999077, Hong Kong, China.

The ternary strategy has been widely used in high-efficiency organic solar cells (OSCs). Herein, we successfully incorporated a mid-band-gap star-shaped acceptor, FBTIC, as the third component into the PM6/Y6 binary blend film, which not only achieved a panchromatic absorption but also significantly improved the open-circuit voltage () of the devices due to the high-lying lowest unoccupied molecular orbital (LUMO) of the FBTIC. Morphology characterizations show that star-shaped FBTIC molecules are amorphously distributed in the ternary system, and the finely tuned ternary film morphology facilitates the exciton dissociation and charge collection in ternary devices. Read More

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http://dx.doi.org/10.1021/acsami.0c14612DOI Listing
October 2020

Perceptions of Midwives on Pap Smear Tests during Pregnancy.

Asian Pac J Cancer Prev 2020 Oct 1;21(10):3039-3043. Epub 2020 Oct 1.

Department of Health Care Sciences, Sefako Makgatho Health Sciences University, South Africa.

Purpose: The aim of the study was to explore and describe perceptions of midwives on Papanicolaou (Pap smear) test during pregnancy.

Methods: The study used qualitative, exploratory type of design. A probability purposive sampling was used to sample 12 registered midwives based in gynaecological units in a public hospital in Tshwane District, South Africa. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.10.3039DOI Listing
October 2020

[Breastfeeding for HIV-positive mothers in Switzerland : are we ready to discuss ?]

Rev Med Suisse 2020 Oct;16(712):2050-2054

Service d'obstétrique, Département Femme, Enfant, Adolescent, HUG, 1211 Genève 14.

Mother-to-child transmission (MTCT) is almost inexistent in Switzerland nowadays. This success has been achieved with systematic screening of HIV in pregnant women, provision of antiretroviral treatment (ART), elective cesarean-section (CS), neonatal antiretroviral prophylaxis (ARP) and avoidance of breastfeeding. Elective CS and neonatal ARP are no longer recommended when the viral load (VL) is suppressed. Read More

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October 2020

[Treatment of early cervical cancer : Back to the future].

Rev Med Suisse 2020 Oct;16(712):2046-2049

Service de gynécologie, CHUV, 1011 Lausanne.

The treatment of the early-stage cervical cancer is surgical. In the last ten years we have seen a surgical de-escalation and the development of new techniques such as the sentinel node biopsy. In 2018, absolutely against the trend, the study published in the New England Journal of Medicine by Pedro Ramirez upset the world of gynecologic-oncologists by demonstrating that the open approach is superior to the minimally invasive technique in the surgical management of these cancers. Read More

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October 2020

Low-intensity pulsed ultrasound ameliorates depression-like behaviors in a rat model of chronic unpredictable stress.

CNS Neurosci Ther 2020 Oct 28. Epub 2020 Oct 28.

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

Introduction: There is an unmet need for better nonpharmaceutical treatments for depression. Low-intensity pulsed ultrasound (LIPUS) is a novel type of neuromodulation that could be helpful for depressed patients.

Objective: The goal of this study was to investigate the feasibility and potential mechanisms of LIPUS in the treatment of depression. Read More

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http://dx.doi.org/10.1111/cns.13463DOI Listing
October 2020

The role of the cytoskeletal proteins MreB and FtsZ in multicellular cyanobacteria.

FEBS Open Bio 2020 Oct 28. Epub 2020 Oct 28.

Institute of General Microbiology, Christian-Albrechts University of Kiel, Kiel, Germany.

Multiseriate and true-branching cyanobacteria are at the peak of prokaryotic morphological complexity. However, little is known about the mechanisms governing multiplanar cell-division and morphogenesis. Here, we study the function of the prokaryotic cytoskeletal proteins, MreB and FtsZ in Fischerella muscicola PCC 7414 and Chlorogloeopsis fritschii PCC 6912. Read More

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http://dx.doi.org/10.1002/2211-5463.13016DOI Listing
October 2020

Sustained efficacy of incobotulinumtoxinA in upper-limb post-stroke spasticity: A post hoc analysis.

J Rehabil Med 2020 Oct 28. Epub 2020 Oct 28.

Faculty of Medicine and Dentistry and University Hospital, Palacký University Olomouc, Olomouc, Czech Republic. E-mail:

Objective: This post hoc analysis assessed the impact of repeated incobotulinumtoxinA injections on muscle tone, disability, and caregiver burden in adults with upper-limb post-stroke spasticity.

Design: Data from the double-blind, placebo-controlled main period and 3 open-label extension cycles of 2 Phase 3, randomized, multicentre trials were pooled.

Methods: Subjects received incobotulinumtoxinA 400 Units at 12-week intervals (±3 days) (study 3001, NCT01392300) or ≤ 400 Units at ≥ 12-week intervals based on clinical need (study 0410, NCT00432666). Read More

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http://dx.doi.org/10.2340/16501977-2760DOI Listing
October 2020

Comparative Performance of Private Equity-Owned US Nursing Homes During the COVID-19 Pandemic.

JAMA Netw Open 2020 Oct 1;3(10):e2026702. Epub 2020 Oct 1.

Department of Population Health Sciences, Weill Cornell Medical College, New York, New York.

Importance: It is not known whether nursing homes with private equity (PE) ownership have performed better or worse than other nursing homes during the coronavirus disease 2019 (COVID-19) pandemic.

Objective: To evaluate the comparative performance of PE-owned nursing homes on COVID-19 outcomes.

Design, Setting, And Participants: This cross-sectional study of 11 470 US nursing homes used the Nursing Home COVID-19 Public File from May 17, 2020, to July 2, 2020, to compare outcomes of PE-owned nursing homes with for-profit, nonprofit, and government-owned homes, adjusting for facility characteristics. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.26702DOI Listing
October 2020

Assessment of Changes in Rural and Urban Primary Care Workforce in the United States From 2009 to 2017.

JAMA Netw Open 2020 Oct 1;3(10):e2022914. Epub 2020 Oct 1.

Department of Public Health Policy and Management, School of Global Public Health, New York University, New York.

Importance: Access to primary care clinicians, including primary care physicians and nonphysician clinicians (nurse practitioners and physician assistants) is necessary to improving population health. However, rural-urban trends in primary care access in the US are not well studied.

Objective: To assess the rural-urban trends in the primary care workforce from 2009 to 2017 across all counties in the US. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.22914DOI Listing
October 2020

National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland.

JAMA Netw Open 2020 Oct 1;3(10):e2022897. Epub 2020 Oct 1.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.

Importance: Acetaminophen (paracetamol) is among the most widely used pain medications worldwide; while safe within the therapeutic range, intake exceeding 4000 mg/d can lead to hepatotoxicity. Prior evidence suggests that limiting the availability of large quantities of acetaminophen is associated with decreased acetaminophen-related poisonings and mortality; in Switzerland, 500-mg tablets are available over-the-counter (OTC) and, as of October 2003, 1000-mg tablets are available with prescription.

Objective: To evaluate the association of adding 1000-mg acetaminophen tablets to the Swiss market with utilization and poisonings. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.22897DOI Listing
October 2020

Assessment of Outcomes Among Patients With Venous Thromboembolism With and Without Chronic Kidney Disease.

JAMA Netw Open 2020 Oct 1;3(10):e2022886. Epub 2020 Oct 1.

University College London, London, United Kingdom.

Importance: Patients with venous thromboembolism (VTE) and concomitant chronic kidney disease (CKD) have been reported to have a higher risk of thrombosis and major bleeding complications compared with patients without concomitant CKD. The use of anticoagulation therapy is challenging, as many anticoagulant medications are excreted by the kidney. Large-scale data are needed to clarify the impact of CKD for anticoagulant treatment strategies and clinical outcomes of patients with VTE. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.22886DOI Listing
October 2020

Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants.

JAMA Netw Open 2020 Oct 1;3(10):e2022847. Epub 2020 Oct 1.

Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco.

Importance: Several clinical trials are planned for familial forms of frontotemporal lobar degeneration (f-FTLD). Precise modeling of brain atrophy in f-FTLD could improve the power to detect a treatment effect.

Objective: To characterize regions and rates of atrophy in the 3 primary f-FTLD genetic groups (MAPT, GRN, and C9orf72) across all disease stages from asymptomatic to dementia. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.22847DOI Listing
October 2020

Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations.

JAMA Netw Open 2020 Oct 1;3(10):e2021692. Epub 2020 Oct 1.

Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Importance: DNA repair gene aberrations occur in 20% to 30% of patients with castration-resistant prostate cancer (CRPC), and some of these aberrations have been associated with sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition platinum-based treatments. However, previous trials assessing platinum-based treatments in patients with CRPC have mostly included a biomarker-unselected population; therefore, efficacy in these patients is unknown.

Objective: To characterize the antitumor activity of platinum-based therapies in men with CRPC with or without DNA repair gene alterations. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.21692DOI Listing
October 2020

Homologous Recombination DNA Repair Gene Aberrations-Are We More Alike Than Different?

JAMA Netw Open 2020 Oct 1;3(10):e2021717. Epub 2020 Oct 1.

Division of Hematology and Oncology, University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento.

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http://dx.doi.org/10.1001/jamanetworkopen.2020.21717DOI Listing
October 2020

Should Epidural Analgesia Be Abandoned for Open Pancreatoduodenectomy?

JAMA Surg 2020 Oct 28. Epub 2020 Oct 28.

Francophone Group for Enhanced Recovery After Surgery (GRACE), Beaumont, France.

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http://dx.doi.org/10.1001/jamasurg.2020.4382DOI Listing
October 2020

Should Epidural Analgesia Be Abandoned for Open Pancreatoduodenectomy?-Reply.

JAMA Surg 2020 Oct 28. Epub 2020 Oct 28.

Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1001/jamasurg.2020.4394DOI Listing
October 2020

Electrocatalytic oxidative / isomerization of a stilbene favoured by the presence of an electroactive persistent radical.

Chem Commun (Camb) 2020 Oct 28. Epub 2020 Oct 28.

Department of Molecular Nanoscience and Organic Materials, Institut de Ciència de Materials de Barcelona (ICMAB-CSIC)/CIBER-BBN, Campus Universitari de Bellaterra, E-08193, Cerdanyola, Barcelona, Spain.

A push-pull-functionalized stilbene has been prepared, with an electroactive perchlorotriphenylmethyl (PTM˙) radical and dimethylamine units as electron-withdrawing and -donating moieties, respectively, showing an electrocatalytic redox-induced Z → E isomerization where the open-shell nature of PTM˙ plays a key role in the isomerization ocurrance. Read More

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http://dx.doi.org/10.1039/d0cc04973eDOI Listing
October 2020

Recommendations From the Twitter Hashtag #DoctorsAreDickheads: Qualitative Analysis.

J Med Internet Res 2020 Oct 28;22(10):e17595. Epub 2020 Oct 28.

Center for Vulnerable Populations, University of California San Francisco, San Francisco, CA, United States.

Background: The social media site Twitter has 145 million daily active users worldwide and has become a popular forum for users to communicate their health care concerns and experiences as patients. In the fall of 2018, a hashtag titled #DoctorsAreDickheads emerged, with almost 40,000 posts calling attention to health care experiences.

Objective: This study aims to identify common health care conditions and conceptual themes represented within the phenomenon of this viral Twitter hashtag. Read More

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http://dx.doi.org/10.2196/17595DOI Listing
October 2020

Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology.

Elife 2020 Oct 28;9. Epub 2020 Oct 28.

Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Sorbonne Université, INSERM, CNRS, Paris, France.

Glutamate delta (GluD) receptors belong to the ionotropic glutamate receptor family, yet they don't bind glutamate and are considered orphan. Progress in defining the ion channel function of GluDs in neurons has been hindered by a lack of pharmacological tools. Here we used a chemo-genetic approach to engineer specific and photo-reversible pharmacology in GluD2 receptor. Read More

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http://dx.doi.org/10.7554/eLife.59026DOI Listing
October 2020

Assessing United States County-Level Exposure for Research on Tropical Cyclones and Human Health.

Environ Health Perspect 2020 Oct 28;128(10):107009. Epub 2020 Oct 28.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background: Tropical cyclone epidemiology can be advanced through exposure assessment methods that are comprehensive and consistent across space and time, as these facilitate multiyear, multistorm studies. Further, an understanding of patterns in and between exposure metrics that are based on specific hazards of the storm can help in designing tropical cyclone epidemiological research.

Objectives: ) Provide an open-source data set for tropical cyclone exposure assessment for epidemiological research; and ) investigate patterns and agreement between county-level assessments of tropical cyclone exposure based on different storm hazards. Read More

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http://dx.doi.org/10.1289/EHP6976DOI Listing
October 2020

Therapeutic Effect of Acetabular Fractures Using the Pararectus Approach Combined with 3D Printing Technique.

Orthop Surg 2020 Oct 28. Epub 2020 Oct 28.

Department of Orthopaedics, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Objective: To explore the clinical efficacy of pararectus approach combined with 3D printing technique for the surgical treatment of partial acetabular fractures.

Methods: We retrospectively evaluated 33 (20 males and 13 females) patients with acetabular fractures in the period of June 2017 to December 2018. According to Judet and Letournel classification: 11 cases were of anterior column fracture, 10 cases were of double column fracture, seven fractures were of the anterior column with posterior half transverse, three fractures were of transverse fracture, and two cases were of "T" fracture. Read More

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http://dx.doi.org/10.1111/os.12738DOI Listing
October 2020
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