15 results match your criteria Open Journal of Genetics

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Dissecting the roles of FTZ-F1 in larval molting and pupation, and the sublethal effects of methoxyfenozide on Helicoverpa armigera.

Pest Manag Sci 2021 Mar 12;77(3):1328-1338. Epub 2020 Nov 12.

Institute of Entomology, Jiangxi Agricultural University, Nanchang, China.

Background: In holometabolous insects, the major developmental transitions - larval molting and pupation - are triggered by a pulse of 20-hydroxyecdysone (20E) and coordinated by juvenile hormone. Methoxyfenozide (MF), an ecdysteroid agonist, represents a new class of insect growth regulators and is effective against lepidopteran pests. Fushi-tarazu factor 1 (FTZ-F1) is an ecdysone-inducible transcription factor. Read More

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Genome-wide characterization of tea plant (Camellia sinensis) Hsf transcription factor family and role of CsHsfA2 in heat tolerance.

BMC Plant Biol 2020 May 29;20(1):244. Epub 2020 May 29.

Henan Key Laboratory of Tea Plant Comprehensive Utilization in South Henan, Xinyang Agriculture and Forestry University, Xinyang, 464000, China.

Background: Heat stress factors (Hsfs) play vital roles in signal transduction pathways operating in responses to environmental stresses. However, Hsf gene family has not been thoroughly explored in tea plant (Camellia sinensis L.). Read More

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Chromosome-level genome assembly of the greenfin horse-faced filefish (Thamnaconus septentrionalis) using Oxford Nanopore PromethION sequencing and Hi-C technology.

Mol Ecol Resour 2020 Jul 9;20(4):1069-1079. Epub 2020 Jul 9.

Qingdao Municipal Ocean Technology Achievement Promotion Center, Qingdao, China.

The greenfin horse-faced filefish, Thamnaconus septentrionalis, is a valuable commercial fish species that is widely distributed in the Indo-West Pacific Ocean. This fish has characteristic blue-green fins, rough skin and a spine-like first dorsal fin. Thamnaconus septentrionalis is of conservation concern because its population has declined sharply, and it is an important marine aquaculture fish species in China. Read More

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Inheritance and quantitative trait loci analyses of the anthocyanins and catechins of Camellia sinensis cultivar 'Ziyan' with dark-purple leaves.

Physiol Plant 2020 Sep 13;170(1):109-119. Epub 2020 May 13.

College of Horticulture, Sichuan Agricultural University, Chengdu, 611130, China.

Owing to the potential health benefits, anthocyanin-rich teas (Camellia sinensis) have attracted interest over the past decade. Previously, we developed the cultivar 'Ziyan,' which has dark-purple leaves because of the accumulation of a high amount of anthocyanins. In this study, we performed a genetic analysis of this anthocyanin-rich tea cultivar and 176 of its naturally pollinated offspring. Read More

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September 2020

A genome-wide association study implicates the BMP7 locus as a risk factor for nonsyndromic metopic craniosynostosis.

Hum Genet 2020 Aug 7;139(8):1077-1090. Epub 2020 Apr 7.

Department of Epidemiology, College of Public Health, The University of Iowa, 145 N Riverside Dr, S416 CPHB, Iowa City, IA, 52242, USA.

Our previous genome-wide association study (GWAS) for sagittal nonsyndromic craniosynostosis (sNCS) provided important insights into the genetics of midline CS. In this study, we performed a GWAS for a second midline NCS, metopic NCS (mNCS), using 215 non-Hispanic white case-parent triads. We identified six variants with genome-wide significance (P ≤ 5 × 10): rs781716 (P = 4. Read More

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Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

Epilepsia 2019 11 13;60(11):2314-2324. Epub 2019 Oct 13.

4Brain, Department of Neurology, Ghent University, Ghent, Belgium.

Objective: More than one-third of patients with temporal lobe epilepsy (TLE) continue to have seizures despite treatment with antiepileptic drugs, and many experience severe drug-related side effects, illustrating the need for novel therapies. Selective expression of inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) allows cell-type-specific reduction of neuronal excitability. In this study, we evaluated the effect of chemogenetic suppression of excitatory pyramidal and granule cell neurons of the sclerotic hippocampus in the intrahippocampal mouse model (IHKA) for temporal lobe epilepsy. Read More

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November 2019

G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells.

J Exp Clin Cancer Res 2019 Jul 16;38(1):311. Epub 2019 Jul 16.

Department of Science, University Roma Tre, Rome, Italy.

Background: Glioblastoma is the most aggressive and most lethal primary brain tumor in the adulthood. Current standard therapies are not curative and novel therapeutic options are urgently required. Present knowledge suggests that the continued glioblastoma growth and recurrence is determined by glioblastoma stem-like cells (GSCs), which display self-renewal, tumorigenic potential, and increased radio- and chemo-resistance. Read More

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Peptide P11 suppresses the growth of human thyroid carcinoma by inhibiting the PI3K/AKT/mTOR signaling pathway.

Mol Biol Rep 2019 Jun 26;46(3):2665-2678. Epub 2019 Apr 26.

School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475004, China.

Thyroid carcinoma is the most common endocrine malignancy, and the incidence of thyroid carcinoma is increasing in recent decades. CYYGQSKYC (P6), a nonapeptide with anti-lymphangiogenic effect by its binding to VEGFR-3 and selectively inhibiting VEGF-C binding to VEGFR-3, could suppress the migration and invasion of cancer cells. LSPPRYP (P9) acts as an effective bFGF/FGFR antagonist and inhibits the growth of the murine melanoma B16-F10 cells. Read More

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Methyl Salicylate Enhances Flavonoid Biosynthesis in Tea Leaves by Stimulating the Phenylpropanoid Pathway.

Molecules 2019 Jan 21;24(2). Epub 2019 Jan 21.

Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, 9 Meiling Road, Hangzhou 310008, China.

The phytohormone salicylic acid (SA) is a secondary metabolite that regulates plant growth, development and responses to stress. However, the role of SA in the biosynthesis of flavonoids (a large class of secondary metabolites) in tea ( L.) remains largely unknown. Read More

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January 2019

Novel circular DNA viruses associated with Apiaceae and Poaceae from South Africa and New Zealand.

Arch Virol 2019 Jan 15;164(1):237-242. Epub 2018 Sep 15.

The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine and School of Life Sciences, Arizona State University, Tempe, AZ, 85287-5001, USA.

Advances in molecular techniques used in viral metagenomics coupled with high throughput sequencing is rapidly expanding our knowledge of plant-associated virus diversity. Applying such approaches, we have identified five novel circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA viruses from Poaceae and Apiaceae plant from South Africa and New Zealand. These viruses have a simple genomic organization, including two open reading frames that likely encode a Rep and a capsid protein (CP), a conserved nonanucleotide motif on the apex of a putative stem loop structure, and conserved rolling-circle replication and helicase motifs within their likely Rep: all suggesting that they replicate through rolling-circle replication. Read More

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January 2019

Single-stranded RNA viruses infecting the invasive Argentine ant, Linepithema humile.

Sci Rep 2017 06 12;7(1):3304. Epub 2017 Jun 12.

Centre for Biodiversity and Restoration Ecology, School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.

Social insects host a diversity of viruses. We examined New Zealand populations of the globally widely distributed invasive Argentine ant (Linepithema humile) for RNA viruses. We used metatranscriptomic analysis, which identified six potential novel viruses in the Dicistroviridae family. Read More

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The influence of disease categories on gene candidate predictions from model organism phenotypes.

J Biomed Semantics 2014 3;5(Suppl 1 Proceedings of the Bio-Ontologies Spec Interest G):S4. Epub 2014 Jun 3.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA Hinxton, UK.

Background: The molecular etiology is still to be identified for about half of the currently described Mendelian diseases in humans, thereby hindering efforts to find treatments or preventive measures. Advances, such as new sequencing technologies, have led to increasing amounts of data becoming available with which to address the problem of identifying disease genes. Therefore, automated methods are needed that reliably predict disease gene candidates based on available data. Read More

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Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families.

Open J Genet 2013 Dec;3(4):243-252

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Background: A previous genome-wide linkage study of alcohol dependence in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and D1S2878. The KIAA0040 gene has been mapped to this region (1q24 - q25). A recent genome-wide association study using SAGE (the Study of Addiction: Genetics and Environment) and COGA (Collaborative Study on the Genetics of Alcoholism) found five SNPs within the KIAA0040 gene significantly associated with alcohol dependence. Read More

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December 2013

Distinctive origins of group I introns found in the COXI genes of three gree algae.

Gene 1998 Jun;213(1-2):1-7

Department of Biology, Faculty of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Upon surveying the cytochrome c oxidase subunit I (COXI) gene of green algae, we found group I introns in three species of algae, Chlorella vulgaris (Cv), Scenedesmus quadricauda (Sq) and Protosiphon botryoides (Pb). The comparative analysis of these nucleotide sequences and their secondary structures revealed that the introns of Cv, Sq, and Pb belong to groups IB1, ID, and IB2, respectively. Each of the three introns contained an open reading frame (ORF) that showed a similarity to the sequence of the LAGLIDADG endonuclease family. Read More

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