3 results match your criteria Open Journal of Clinical Diagnostics

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Keeping an Open Mind: tracheostomy for patients with COVID-19.

Anesth Analg 2021 Jan 8;Publish Ahead of Print. Epub 2021 Jan 8.

Michael J. Brenner, MD, FACS Associate Professor and Co-Director of Branch Science, Medical School President, Global Tracheostomy Collaborative, Raleigh NC Chair, Centralized Otolaryngology Research Efforts, American Academy of Otolaryngology - Head & Neck Surgery, Alexandria, VA Department of Otolaryngology - Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States

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January 2021

Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery.

Crit Care Med 2021 Jan 5;Publish Ahead of Print. Epub 2021 Jan 5.

Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia. Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia. Department of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia. Department of Critical Care Medicine, Hospital Sirio-Libanes, São Paulo, Brazil. College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. Department of Medicine, Denver Health, Denver, CO. Crowe Associates, Oxon, United Kingdom. Department of Medicine, Pulmonary Sciences and Critical Care, Denver Health, Denver, CO., School of Medicine, University of Colorado Anschutz, Denver, CO. Editorial and Methods Department, Cochrane, London, United Kingdom. Cochrane Australia, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea. Department of Internal Medicine, Faculty of Medicine, University of Chile, Santiago, Chile. Department of Surgery, University of Toronto, Toronto, Canada. Department of Critical Care Medicine, University of Toronto, Toronto, Canada. Telethon Kids Institute, Perth, Australia. Department of Medicine, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. Division of Critical Care and Pulmonology, Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. School of Medicine, Johns Hopkins University, Baltimore, MD. Critical Care Centre, CHU Lille, Lille University, Lille, France. Nova Medical School, CHRC, New University of Lisbon, Polyvalent Intensive Care Unit, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal. Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, Odense University Hospital, Odense, Denmark. Department of Anesthesiology and Intensive Care, Jena University Hospital, Jena, Germany. Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China. Evidence Based Child Health Group, University of Nottingham, Nottingham, United Kingdom. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. Sydney Children's Hospital Network, Westmead, NSW, Australia. Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA, Australia. Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. Department of Pulmonology Hospital Clinic, University of Barcelona, CIBERESUCICOVID, IDIBAPS, ICREA, Barcelona, Spain. Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom. Section of Infectious Diseases, Department of Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX. Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Objectives: Respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality have been identified as critically important core outcomes by more than 9300 patients, health professionals, and the public from 111 countries in the global coronavirus disease 2019 core outcome set initiative. The aim of this project was to establish the core outcome measures for these domains for trials in coronavirus disease 2019.

Design: Three online consensus workshops were convened to establish outcome measures for the four core domains of respiratory failure, multiple organ failure, shortness of breath, and recovery. Read More

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January 2021

SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells.

Open J Clin Diagn 2013 Jun;3(2):37-51

Angiogenesis Core Facility, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA.

The gut hormone apelin is a major therapeutic focus for several diseases involving inflammation and aberrant cell growth. We investigated whether apelin-36 contained alternative bioactive peptides associated with normal physiology or disease. Amino acid sequence analysis of apelin-36 identified an amidation motif consistent with the formation of a secondary bioactive peptide (SCNH2). Read More

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