508,876 results match your criteria Open Access Surgery [Journal]


Endoscopic vacuum therapy with open-pore film drainage for colonic anastomotic leakage in a morbidly obese patient.

Endoscopy 2018 Dec 14. Epub 2018 Dec 14.

Department for General, Visceral and Oncological Surgery, Klinikum St. Georg gGmbH, Leipzig, Germany.

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December 2018

The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Read More

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December 2018

In vitro breeding: application of embryonic stem cells to animal production.

Biol Reprod 2018 Dec 14. Epub 2018 Dec 14.

Department of Animal Science, University of California, Davis, CA.

Embryonic stem cells (ESCs) are derived from the inner cell mass of preimplantation blastocysts. For decades, attempts to efficiently derive ESCs in animal livestock species have been unsuccessful, but this goal has recently been achieved in cattle. Together with the recent reconstitution of the germ cell differentiation processes from ESCs in mice, these achievements open new avenues for the development of promising technologies oriented toward improving health, animal production and the environment. Read More

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December 2018

Increased incidence rate of hypothyroidism after iodine fortification in Denmark. A 20 year prospective population-based study.

J Clin Endocrinol Metab 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Denmark.

Objective: To monitor the impact of a cautious iodine fortification (IF) on the incidence of overt hypothyroidism in two sub-populations with different levels of preexisting iodine deficiency (ID).

Design: A 20 years (1997-2016) prospective population-based study identified all new cases of diagnosed overt biochemical hypothyroidism in two open cohorts: a Western cohort with moderate ID (n=309,434, January 1st, 1997) and an Eastern cohort with mild ID (n=224,535, January 1st, 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas and possible new cases were verified individually. Read More

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December 2018

Computational conformational analysis of α-thrombin inhibitors possessing distinct scaffolds in aqueous solution and on Ala-sheet.

Authors:
Keigo Gohda

J Mol Graph Model 2018 Dec 3;87:165-171. Epub 2018 Dec 3.

Computer-aided Molecular Modeling Research Center, Kansai (CAMM-Kansai), 3-32-302, Tsuto-Otsuka, Nishinomiya, 663-8241, Japan. Electronic address:

Recent computational simulations on protein-ligand binding/unbinding have precisely been uncovering the ligand-binding process at the atomic level. In the process, the non-specific binding of ligands to the target site is suggested to occur before binding to the target. We in this study analyzed the conformations of ligands under the non-specific binding on a protein surface to figure out the differences in the conformational characteristics in aqueous solution using the 55-ns molecular dynamic simulation. Read More

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December 2018

Lacking evidence for the association between frequent urine drug screening and health outcomes of persons on opioid agonist therapy.

Int J Drug Policy 2018 Dec 11;64:30-33. Epub 2018 Dec 11.

British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada; School of Medicine, University College Dublin, Health Sciences Centre, Belfield, Dublin 4, Ireland. Electronic address:

Background: Opioid agonist therapy (OAT) is a first-line treatment for opioid use disorder (OUD); however, the efficacy and role of urine drug screening (UDS) in OAT has received little research attention. Prior evidence suggests that UDS frequency reflects philosophy and practice context rather than differences in patient characteristics or clinical need. Therefore, we reviewed the literature on the effect of and recommendations for the frequency of UDS on health outcomes for persons with OUD who receive OAT. Read More

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December 2018

Promoting opioid overdose prevention and recovery: An exploratory study of an innovative intervention model to address opioid abuse.

Int J Drug Policy 2018 Dec 11;64:21-29. Epub 2018 Dec 11.

NJ Division of Mental Health and Addiction Services, Office of Planning, Research, Evaluation and Prevention, 222 South Warren Street, Trenton, NJ 08625-0700, United States. Electronic address:

Background: Fatal opioid overdose is a national public health concern in the United States and a critical problem confronting New Jersey's addiction treatment system. New Jersey developed an innovative program, the Opioid Overdose Recovery Program (OORP), to address the epidemic and the issue of low treatment admissions following a non-fatal overdose. The OORP utilizes an intervention model with peer recovery specialists (RSs) and patient navigators (PNs) to engage individuals within emergency departments (EDs) immediately following an opioid overdose reversal. Read More

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December 2018

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

University of Saskatchewan, Department of Physiology, Saskatoon, SK, Canada.

Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype closely correlated to that of human absence epilepsies. Similar to the human conditions, GAERS display social abnormalities. Read More

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December 2018

International priorities for home care education, research, practice, and management: Qualitative content analysis.

Nurse Educ Today 2018 Dec 7;73:83-87. Epub 2018 Dec 7.

Case Western Reserve University, United States of America. Electronic address:

Background: Despite growing demand for home care nursing, there is a growing home care workforce shortage, due in part to hospital-centric nursing curricula that lead students to undervalue of home care and community practice setting (Van Iersel et al., 2018a, 2018b).

Objectives: Articulate an international vision for the future of home care education, research, practice, and management shared by experienced home care nurses working in leadership roles. Read More

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December 2018

Tracing lake mixing and oxygenation regime using the Fe/Mn ratio in varved sediments: 2000 year-long record of human-induced changes from Lake Żabińskie (NE Poland).

Sci Total Environ 2018 Dec 6;657:585-596. Epub 2018 Dec 6.

Faculty of Oceanography and Geography, University of Gdansk, Poland.

This study explores the long-term drivers of changes in lake mixing regime and the causes of lacustrine anoxia in the 2000 year-long, varved sediment record from Lake Żabińskie in northeastern Poland. Annually resolved geochemical data (μXRF and CNS) and pollen data were used to find links between changes in catchment land use and lake mixing regime. Furthermore, we tested the applicability of the Fe/Mn ratio for the reconstruction of past water ventilation. Read More

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December 2018

CGRP Antibodies as Prophylaxis in Migraine.

Authors:
Lars Edvinsson

Cell 2018 Dec;175(7):1719

Department of Medicine, University Hospital, Lund, Sweden. Electronic address:

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP ligand, were approved by the FDA in September 2018. Read More

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December 2018

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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December 2018

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5862-5867

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG).

Methods: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories. Read More

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December 2018

Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.

PLoS One 2018 14;13(12):e0208782. Epub 2018 Dec 14.

Institute of Systems Biology, Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, Spain.

Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of purifying selection can be measured. This has made possible to know where, in the metabolic network, adaptive selection has acted and where purifying selection is more or less strong and efficient. Read More

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December 2018

Laparoscopic versus open appendectomy for complicated appendicitis.

Medwave 2018 Dec 11;18(8):e7370. Epub 2018 Dec 11.

Proyecto Epistemonikos, Santiago, Chile; Centro Evidencia UC, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: The treatment of acute appendicitis using laparoscopy reduces the risk of wound infection, hospitalization time and return to normal activity. However, it increases the risk of intra-abdominal abscess, which is one the main complications of complicated appendicitis.

Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. Read More

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December 2018

VESSEL DENSITY OF SUPERFICIAL, INTERMEDIATE, AND DEEP CAPILLARY PLEXUSES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Retina 2018 Dec 6. Epub 2018 Dec 6.

Service d'Ophtalmologie, Hôpital Lariboisière, AP-HP, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Sorbonne Paris Cité, France.

Purpose: To provide values of retinal vessel density (VD) in the three retinal capillary plexuses, foveal avascular zone (FAZ) area, and retinal layer thickness in a cohort of healthy subjects.

Methods: The optical coherence tomography angiography maps of 148 eyes of 84 healthy subjects, aged 22 to 76 years, were analyzed for measuring VD of the retinal capillary plexuses, using the Optovue device comprising a projection artifact removal algorithm. Foveal avascular zone metrics were measured, and the relationship between optical coherence tomography angiography findings and age, sex, and image quality was studied. Read More

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December 2018

Impact of a Nutrition-Focused Quality Improvement Intervention on Hospital Length of Stay.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Clinical Nutrition, Sodexo Healthcare, Gaithersburg, Maryland (Ms Siegel and Mr Higgins); Department of Agricultural Economics, Mississippi State University, Starkville, Mississippi (Dr Fan); Catholic Heath Initiatives, Denver, Colorado (Ms Goldman); and Health Economics and Outcomes Research, Abbott Nutrition Research and Development, Columbus, Ohio (Drs Goates and Partridge).

Background: Despite its high prevalence, malnutrition in hospitalized patients often goes unrecognized and undertreated.

Local Problem: A hospital system sought to improve nutrition care by implementing a quality improvement initiative. Nurses screened patients upon admission using the Malnutrition Screening Tool and initiated oral nutrition supplements for patients at risk. Read More

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December 2018

Exploring the Delivery of Healthcare in the Police Detention Center Through Remote Presence Technology.

J Forensic Nurs 2018 Dec 13. Epub 2018 Dec 13.

Office of the Vice-President Research, University of Saskatchewan.

Introduction: There is overwhelming evidence to support the delivery of high-quality health service at a lower cost with the use of advanced technologies. Implementing remote presence technology to expand clinical care has been fraught with barriers that limit interprofessional collaboration and optimal client outcomes. In Canada, government ministries responsible for correctional services, policing, and health are well positioned to link federal, provincial, and regional services to enhance service delivery at the point of care for individuals detained within the justice system. Read More

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December 2018

Third Molar Eruption and Hardware Fungal Infection Following Treatment of Mandibular Angle Fracture.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic Surgery, University of Virginia Health System.

Appropriate management of lower 3rd molars is crucial to successful treatment of mandibular angle fractures. A unique case of a patient who presented for initial management of a left mandibular angle fracture with an unerupted lower 3rd molar was discussed in this study. After treatment with open reduction and internal fixation of the fracture, the lower 3rd molar erupted and the patient subsequently developed fungal osteomyelitis and hardware failure. Read More

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December 2018

Ruptured Extensor Pollicis Longus Tendon After a Nondisplaced Distal Radius Fracture in a Young Adult Soccer Player.

Clin J Sport Med 2018 Dec 13. Epub 2018 Dec 13.

HealthONE Family Medicine Residency, Lone Tree, Colorado.

Forearm fractures of the distal radius are one of the most common fractures seen in the upper extremity, and they represent approximately 1/6 of fractures treated in the emergency department. Forearm fractures are associated with a rare but known complication of a delayed ruptured extensor pollicis longus (EPL) tendon. This sequela is more commonly seen in adults after a nondisplaced distal radius fracture, with much variability in the incidence ranging from 0. Read More

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December 2018

Postural Control Deficits After Repetitive Soccer Heading.

Clin J Sport Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.

Objective: To determine the acute effects of repetitive soccer heading on postural control.

Design: Prospective study; participants were divided into 2 groups: a soccer heading group and a control group.

Setting: Biomechanics laboratory. Read More

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December 2018

HIV DIAGNOSIS FOLLOWING A SYPHILIS, GONORRHEA, OR REPEAT DIAGNOSIS AMONG MALES INCLUDING NON-MSM: WHAT IS THE INCIDENCE?

Sex Transm Dis 2018 Dec 13. Epub 2018 Dec 13.

Center for Child and Community Health Research (CCHR), Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: The release of the first drug for HIV pre-exposure prophylaxis (PrEP) in 2012 marked the beginning of a new era of HIV prevention. Although PrEP is highly efficacious, identifying and ultimately increasing uptake among the highest risk male subgroups remains a challenge.

Methods: Public health surveillance data from 2009-2016 was used to evaluate the risk of an HIV diagnosis following a syphilis (i. Read More

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December 2018
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A Match-Derived Relative Pitch Area Facilitates the Tactical Representativeness of Small-Sided Games for the Official Soccer Match.

J Strength Cond Res 2018 Dec 13. Epub 2018 Dec 13.

Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Olthof, SBH, Frencken, WGP, and Lemmink, KAPM. A match-derived relative pitch area facilitates the tactical representativeness of small-sided games for the official soccer match. J Strength Cond Res XX(X): 000-000, 2018-Small-sided games (SSGs) are a promising training format in soccer to replicate (situations of) the official match across all age groups. Read More

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December 2018

Psychometric Evaluation of an Instrument to Measure Prospective Pregnancy Preferences: The Desire to Avoid Pregnancy Scale.

Med Care 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Bixby Center for Global Reproductive Health, Advancing New Standards in Reproductive Health (ANSIRH), University of California, San Francisco, School of Medicine, San Francisco.

Background: Existing approaches to measuring women's pregnancy intentions suffer important limitations, including retrospective assessment, overly simple categories, and a presumption that all women plan pregnancies. No psychometrically valid scales exist to prospectively measure the ranges of women's pregnancy preferences.

Materials And Methods: Using a rigorous construct modeling approach, we developed a scale to measure desire to avoid pregnancy. Read More

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December 2018
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Osseointegrated Percutaneous Prosthetic System for the Treatment of Patients With Transfemoral Amputation: A Prospective Five-year Follow-up of Patient-reported Outcomes and Complications.

J Am Acad Orthop Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Centre for Advanced Reconstruction of Extremities (C.A.R.E.), Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Brånemark, Dr. Hagberg, Mrs. Kulbacka-Ortiz, and Dr. Berlin), International Centre for Osseointegration Research, Education and Surgery (iCORES), Department of Orthopaedics, University of California, San Francisco, CA (Dr. Brånemark), and the Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Rydevik).

Introduction: Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up.

Methods: A total of 51 patients (55 legs) with TFA were included in a prospective study. Read More

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December 2018

Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

C Godballe, Department of ORL Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

A recent study proposed new TNM groupings for better survival discrimination among stage groups for medullary thyroid carcinoma (MTC) and validated these groupings in a population-based cohort in the United States. However, it is unknown how well the groupings perform in populations outside the United States. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current American Joint Committee on Cancer (AJCC) TNM staging system (seventh and eighth edition) in a nationwide MTC cohort outside the United States. Read More

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December 2018

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.

Syst Biol Reprod Med 2018 Dec 14:1-16. Epub 2018 Dec 14.

b Division of Pharmacology and Toxicology , CSIR- Indian Institute of Chemical Technology , Hyderabad , India.

We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). Read More

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December 2018

QAPSA: Post-Marketing Surveillance of Capsaicin 8% Patch for Long-Term Use in Patients with Peripheral Neuropathic Pain in France.

Curr Med Res Opin 2018 Dec 14:1-27. Epub 2018 Dec 14.

b Centre d'Evaluation et de Traitement de la Douleur, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris (AP-HP) , Université Paris Descartes , Paris , INSERM U987 , France.

(236/250 words) Objective: To describe the characteristics of patients treated with the capsaicin 8% patch, prescribing conditions, long-term effects of repeat treatment on pain intensity and perception, quality of life, and impact on concomitant medication.

Methods: A national, longitudinal, prospective, non-interventional, post-marketing open study was conducted in 50 French pain centers. Adult volunteer non-diabetic patients with peripheral neuropathic pain receiving capsaicin 8% patch treatment were consecutively enrolled. Read More

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December 2018

Extended π-Conjugated Structures via Dehydrative C-C Coupling.

J Am Chem Soc 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

We describe a methodology for the synthesis of extended aromatic structures through dehydrative C-C coupling from readily accessible diols. Treatment of the diols with a Brønsted acid ( para-toluenesulfonic acid) induces the nucleophilic addition of an arene or heteroarene, yielding fully aromatic products in high to quantitative yields with thiophenes, furan, indole, and N, N-dimethylaniline as coupling partners. The C-C coupling reactions proceed under mild, open flask conditions and offer high atom economy, while providing an attractive alternative approach to metal-catalyzed cross-coupling. Read More

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December 2018

Adsorption Structure of Mono- and Diradicals on a Cu(111) Surface: Chemoselective Dehalogenation of 4-Bromo-3''-iodo- p-terphenyl.

ACS Nano 2018 Dec 14. Epub 2018 Dec 14.

Selectivity is a key parameter for building customized organic nanostructures via bottom-up approaches. Therefore, strategies are needed, which allow connecting molecular entities at a specific stage of the assembly process in a chemoselective manner. Studying the mechanisms of such reactions is the key to apply these transformations for the build-up of organic nanostructures on surfaces. Read More

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December 2018

[Assistant cooperation and therapeutic effect analysis in transoral robotic surgery with da Vinci surgical system].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1074-1077

Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

The purpose of this study was to summarize the therapeutic effect and key points and skills of assistant cooperation in transoral robotic surgery (TORS) with da Vinci surgical system.Forty patients were reviewed who were treated with TORS in Beijing Anzhen Hospital from June 1, 2016 to May 30, 2018. Key points of assistant cooperation, docking time, incidence of transit to open approach, mechanical failure, complications, and negative surgical margin were analyzed. Read More

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[Robot-assisted transaxillary thyroidectomy: our early experience].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1051-1055

Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.

To evaluate the feasibility, effectiveness and safety of robot-assisted transaxillary thyroidectomy (RATT). The clinical data of 66 patients undergoing RATT from November 2016 to May 2018 were prospectively collected and analyzed. The average age was (38. Read More

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[Iatrogenic femoral head fracture during a closed reduction of posterior dislocation of hip. Case report].

Acta Ortop Mex 2018 Jul-Aug;32(4):234-239

Servicio de Cadera y Pelvis del Hospital General de Querétaro. Querétaro, México.

The fracture dislocation of the hip is a rare lesion described up to 4 to 17% of the cases and usually secondary to automobile accidents. Generally of poor prognosis and with already well documented complications such as avascular necrosis of the femoral head, osteoarthritis and heterotopic ossification. The iatrogenic fracture of the neck or head of the proximal femur is a complication even more rare and is not documented its incidence in the world literature. Read More

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December 2018

Early Placebo Improvement Is a Marker for Subsequent Placebo Response in Long-Acting Injectable Antipsychotic Trials for Schizophrenia: Combined Analysis of 4 RCTs.

J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.

Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Objective: Placebo effects remain largely unexplored in clinical trials of long-acting injectable (LAI) antipsychotics for schizophrenia. This study aims to characterize patients showing improvements after placebo injections and to search for criteria for the prediction of subsequent response based on the magnitude of score changes after the first week of treatment.

Methods: Data from 450 patients with schizophrenia (DSM-IV) who received placebo injections in 4 double-blind randomized controlled trials evaluating efficacy of LAI paliperidone palmitate obtained through the Yale University Open Data Access (YODA) project were analyzed. Read More

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December 2018

Relationship between Progressive Changes in Lamina Cribrosa Depth and Deterioration of Visual Field Loss in Glaucomatous Eyes.

Korean J Ophthalmol 2018 Dec;32(6):470-477

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate the relationship between the progression of visual field (VF) loss and changes in lamina cribrosa depth (LCD) as determined by spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in patients with primary open angle glaucoma (POAG).

Methods: Data from 60 POAG patients (mean follow-up, 3.5 ± 0. Read More

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December 2018

Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer.

Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.

Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More

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December 2018

Open Microsurgical Dorsal Root Ganglion Lead Placement.

Neuromodulation 2018 Dec 14. Epub 2018 Dec 14.

Department of Stereotactic and Functional Neurosurgery, Heinrich-Heine University, Düsseldorf, Germany.

Introduction: Dorsal root ganglion stimulation (DRG) is a new but well-established neuromodulation technique allowing new indications and superiority to pre-existing stimulation techniques such as spinal cord stimulation in selected pain etiologies. Previous surgical procedures in the implantation area pose a challenge for the percutaneous technique and are therefore considered contraindications for DRG stimulation surgery. We describe the successful open DRG electrode placement in two patients with previous surgeries suffering from severe radiculopathy due to foraminal stenosis. Read More

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December 2018

The Role of Free Tissue Transfer in the Management of Chronic Frontal Sinus Osteomyelitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Objectives/hypothesis: Chronic frontal sinus infection is managed with a combination of medical and surgical interventions. Frontal bone osteomyelitis due to recurrent infection following trauma or prior open surgery may require more significant debridement. Free tissue transfer may allow for extensive debridement with replacement of tissue, and definitive eradication of osteomyelitis. Read More

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December 2018

Laparoscopic reversal of Hartmann's procedure: A single-center experience.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Morphology, Experimental Medicine and Surgery, Section of General and Thoracic Surgery, University of Ferrara, Ferrara, Italy.

Introduction: Laparoscopic reversal of Hartmann's procedure (LHR) is considered a technically complex major surgical procedure. We present a retrospective analysis of a single-institution experience that assesses the treatment patterns and outcomes of patients who underwent LHR.

Materials And Surgical Technique: The study involved patients who underwent LHR between January 2004 and December 2017. Read More

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December 2018

A New Class of Neutral Boron-Based Diradicals Spanned by a Two-Carbon Bridge.

Angew Chem Int Ed Engl 2018 Dec 14. Epub 2018 Dec 14.

Julius Maximilians Universität Würzburg, Department of Chemistry, Am Hubland, 97074, Würzburg, GERMANY.

A new structural class of boron-based diradicals is prepared by Lewis-base addition to and reduction of singly CAAC-stabilised diborylalkenes. The diradicals feature a perpendicular olefinic bridge preventing delocalization between the B(CAAC) π systems, making the coupling between the spin centres very weak. DFT calculations indicate that the compounds are ground-state (open-shell) singlets, with triplet states negligibly higher in energy, thus making the latter easily populated thermally. Read More

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December 2018

An empirical evaluation of multivariate lesion behaviour mapping using support vector regression.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Centre of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Multivariate lesion behaviour mapping based on machine learning algorithms has recently been suggested to complement the methods of anatomo-behavioural approaches in cognitive neuroscience. Several studies applied and validated support vector regression-based lesion symptom mapping (SVR-LSM) to map anatomo-behavioural relations. However, this promising method, as well as the multivariate approach per se, still bears many open questions. Read More

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December 2018

A cross-sectional survey of patients with open surgical wounds in Slovenia.

Health Soc Care Community 2018 Dec 13. Epub 2018 Dec 13.

Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK.

Most surgical wounds heal by primary intention, that is, the wound is closed with sutures, clips, or glue. However, some surgical wounds are either left open to heal from the bottom up ("healing by secondary intention") or break open partially or fully after primary closure. There is little basic knowledge about the occurrence and natural history of surgical wounds healing by secondary intention (SWHSI); therefore, the aim of this survey was to estimate the number of people with SWHSI in Slovenia, the nature of these wounds, and to investigate how they are managed. Read More

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December 2018

Reproductive consequences of variation in flowering phenology in the dry forest tree Enterolobium cyclocarpum in Guanacaste, Costa Rica.

Am J Bot 2018 Dec 13. Epub 2018 Dec 13.

Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, Ciudad Universitaria "Rodrigo Facio", San Pedro de Montes de Oca, San José, Costa Rica.

Premise Of The Study: Flowering initiation, duration and magnitude, and degree of flowering synchrony within a population can affect the reproductive fitness of individuals. We examined the flowering phenology within a population of the tropical dry forest Guanacaste tree (Enterolobium cyclocarpum) to gauge the impact of phenological variation among trees on fruit production and progeny vigor.

Methods: We monitored the flowering phenology of 93 trees weekly during 2005, 2006, and 2007, using a scale based on the percentage of the crown with open flowers. Read More

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December 2018

Synthesis, Photophysical Properties and Two Photon Absorption Study of Tetraazachrysene-based N-heteroacenes.

Authors:
Qichun Zhang

Chem Asian J 2018 Dec 13. Epub 2018 Dec 13.

Nanyang Technological University, MSE, 50 Nanyang Ave, 639672, Singapore, SINGAPORE.

Three novel N-heteroacene molecules (SDNU-1, SDNU-2 and SDNU-3) based on tetraazachrysene units as cores have been designed, synthesized and fully characterized. Their photophysical, electrochemical and fluorescence properties were investigated, and they exhibited blue to green emission in solid state. Interestingly, SDNU-2 exhibited high solid photoluminescence quantum efficiencies (75. Read More

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December 2018

Well-Defined Metal Nanoparticles@Covalent Organic Framework Yolk-Shell Nanocages by ZIF-8 Template as Catalytic Nanoreactors.

Small 2018 Dec 13:e1804419. Epub 2018 Dec 13.

College of Materials Science and Engineering, Fuzhou University, New Campus, Minhou, Fujian, 350108, China.

Yolk-shell nanoreactors have received considerable interest for use in catalysis. However, the controlled synthesis of continuous crystalline shells without imperfections or cracks remains challenging. Here, a strategy for the synthesis of yolk-shell metal nanoparticles@covalent organic framework (MNPs@COF) nanoreactors by using MNPs@ZIF-8 core-shell nanostructures as a self-template is designed and developed. Read More

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December 2018

Metallosupramolecular Photonic Elastomers with Self-Healing Capability and Angle-Independent Color.

Adv Mater 2018 Dec 13:e1805496. Epub 2018 Dec 13.

Key Lab of Materials Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China.

Photonic elastomers that can change colors like a chameleon have shown great promise in various applications. However, it still remains a challenge to produce artificial photonic elastomers with desired optical and mechanical properties. Here, the generation of metallosupramolecular polymer-based photonic elastomers with tunable mechanical strength, angle-independent structural color, and self-healing capability is reported. Read More

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December 2018
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Masticatory Apparatus Performance and Functional Morphology in the Extremely Large Mice from Gough Island.

Anat Rec (Hoboken) 2018 Dec 13. Epub 2018 Dec 13.

Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.

Since their arrival approximately 200 years ago, the house mice (Mus musculus) on Gough Island (GI) rapidly increased in size to become the largest wild house mice on record. Along with this extreme increase in body size, GI mice adopted a predatory diet, consuming significant quantities of seabird chicks and eggs. We studied this natural experiment to determine how evolution of extreme size and a novel diet impacted masticatory apparatus performance and functional morphology in these mice. Read More

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December 2018

Dissociation in awareness of memory and language decline in Alzheimer's disease.

Int J Geriatr Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Center for Memory and Attention Disorders, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Objectives: The aim of this study was to examine awareness of decline in memory and in language in individuals with Alzheimer's disease (AD), by comparing participant and informant ratings, as well as these ratings and actual test performance.

Methods: We analyzed data from 149 individuals with AD enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire, and performed memory and language tasks.

Results: Participants provided significantly lower assessments of decline than did informants for both memory and language. Read More

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December 2018

Pharmacokinetics and pharmacodynamics of intravenous esomeprazole at 2 different dosages in dogs.

J Vet Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.

Background: Although the demand for esomeprazole is increasing in veterinary medicine, the pharmacokinetics (PK) and pharmacodynamics of esomeprazole have been described in only a few studies.

Objective: To determine the PK of 0.5 and 1 mg/kg esomeprazole administered IV q12h and to investigate its effects on intragastric pH in healthy dogs. Read More

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December 2018

'Names will never hurt us': A qualitative exploration of çapulcu identity through the eyes of Gezi Park protesters.

Br J Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.

Özyeğin University, Turkey.

While there is a wealth of literature on how and why people engage in collective action, there has been comparably less focus on the way identities that have emerged (as compared to how they are consolidated or politicized) through crowd action are understood and explained by those who carry those identities, as well as the particular importance of norm formation and adherence in this process. The Gezi Park protests in Turkey allowed studying exactly how a newly created identity - çapulcu identity [Turkish for looters] - can be perceived by the protesters. The present study utilizes a qualitative approach to explore how the çapulcu identity was understood by people who participated in the Gezi Park protests, as well as the norms and prototypes associated with that identity. Read More

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December 2018
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