4,442 results match your criteria Onychomycosis

Tinea pedis - an embarrassing problem for health and beauty - a narrative review.

Mycoses 2021 Jun 18. Epub 2021 Jun 18.

Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Wrocław, Poland.

Fungal infections present with a broad spectrum of diseases in humans (from relatively mild superficial infections of the skin and mucous membranes to the invasive or chronic infections of internal organs, which have a high mortality rate). Globally, up to 1.6 million people die each year as a result of various types of mycoses. Read More

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Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions.

Sci Rep 2021 Jun 17;11(1):12789. Epub 2021 Jun 17.

iBiMed-Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Campus Universitário de Santiago, Agra do Crasto-Edifício 30, 3810-193, Aveiro, Portugal.

Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Read More

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Yellow nail syndrome.

J R Coll Physicians Edinb 2021 06;51(2):166-167

Department of Neurology, Bangur Institute of Neurosciences, IPGMER and SSKM Hospital, Kolkata, India.

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Cure Rates of Control Interventions in Randomized Trials for Onychomycosis Treatments: A Systematic Review and Meta-Analysis.

J Am Podiatr Med Assoc 2021 Jun 11. Epub 2021 Jun 11.

Background: The efficacy of antifungals for onychomycosis has been determined in randomized controlled trials (RCTs); interestingly their control arms have demonstrated some therapeutic effects. These controls constitute either placebos (inert pills) or vehicles (all but the antifungal component of the creams). The objective of this research was to determine (i) whether RCT controls exhibited statistically-relevant efficacy rates (i. Read More

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Efinaconazole topical solution (10%) for the treatment of onychomycosis in adult and pediatric patients.

Expert Rev Anti Infect Ther 2021 Jun 9. Epub 2021 Jun 9.

Mediprobe Research Inc., London, ON, CAN.

Introduction: Onychomycosis, a common nail disorder caused by fungal infection, can be managed pharmaceutically with oral or topical treatments. While oral treatments are often used first-line to treat nail infections, these systemic antifungals are not appropriate for all patients, and no oral treatments are approved for use in children in the USA. Given this need, topical antifungals were developed, which can be used as monotherapy or in combination with oral drugs. Read More

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A Case of Yellow Nail Syndrome in Which Intranodal Lymphangiography Contributed to the Diagnosis.

Intern Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Respiratory Medicine, Saitama Medical University Hospital, Japan.

Yellow nail syndrome (YNS) is a rare disease comprising the clinical triad of yellow nail discoloration, pleural effusion, and lower limb lymphedema. We encountered a difficult-to-treat case of YNS in which the diagnosis was finally made based on intranodal lymphangiography. An 84-year-old man was admitted to our hospital with pleural effusion and yellow-green discoloration of the nails, accompanied by onychomycosis and limb lymphedema. Read More

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Laboratory monitoring during treatment of onychomycosis in pediatric patients: A survey of provider perspectives and practices.

Pediatr Dermatol 2021 Jun 4. Epub 2021 Jun 4.

Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.

Background/objectives: Literature regarding the cost and necessity of laboratory monitoring during oral antifungal treatment in adults has recently been published. However, consensus guidelines for the treatment and monitoring of pediatric patients with systemic antifungals for onychomycosis are lacking. We sought to evaluate both the practice trends and perspectives of pediatric dermatology providers who treat pediatric onychomycosis. Read More

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A Study of Q-switched Nd:YAG Laser versus Itraconazole in Management of Onychomycosis.

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):93-100

Department of Dermatology, Paras Hospital, Panchkula, Haryana, India.

Context: Onychomycosis (OM) accounts for 20%-40% of all nail disorders. Slow growth of nails, resistance to antifungal drugs, their side effects, and drug interactions limit treatment options. Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser is approved for nail clearance of OM, however conflicting reports exist in literature about its efficacy. Read More

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Report of two siblings with APECED in Serbia: is there a founder effect of c.769C>T AIRE genotype?

Ital J Pediatr 2021 Jun 2;47(1):126. Epub 2021 Jun 2.

Endocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) or autoimmune polyglandular syndrome Type 1 is a rare autosomal recessive syndrome. The disorder is caused by mutations in the AIRE (AutoImmune Regulator) gene. According to the classic criteria, clinical diagnosis requires the presence of at least two of three main components: chronic mucocutaneous candidiasis, hypoparathyroidism and primary adrenal insufficiency. Read More

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Epidemiological aspects of superficial fungal infections in Koranic schools in two localities of Senegal (Thies and Touba).

Mycoses 2021 Jun 2. Epub 2021 Jun 2.

Cheikh Anta Diop University of Dakar, Dakar, Senegal.

Background: In developing countries, superficial fungal infections (SFI) are endemic and cause a therapeutic problem because of the duration and cost of treatment. Community living and promiscuity are key factors in the direct or indirect transmission and spread of these diseases.

Objectives: The objective was to study the epidemiological aspects of SFI, among koranic school children in two localities in Senegal. Read More

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Polishing the Therapy of Onychomycosis Induced by spp.: Amphotericin B-Loaded Nail Lacquer.

Pharmaceutics 2021 May 24;13(6). Epub 2021 May 24.

Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal 59012-570, Brazil.

Onychomycosis induced by spp. has several limitations regarding its treatment. Nail lacquers display the potential to overcome these drawbacks by providing therapeutic compliance and increasing local drug bioavailability. Read More

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Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents.

Molecules 2021 May 31;26(11). Epub 2021 May 31.

The State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co. Ltd., Dongguan 523871, China.

The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. Read More

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Translation and Cross-Cultural Adaptation of Quality of Life Scale in Patients with Onychomycosis.

Int J Environ Res Public Health 2021 May 28;18(11). Epub 2021 May 28.

Department of Medical Sciences, iBiMED-Institute of Biomedicine, Campus Universitário de Santiago, University of Aveiro, Agra do Crasto-Edifício 30, 3810-193 Aveiro, Portugal.

(1) Background: Onychomycosis (OM) is a fungal nail infection, considered a risk factor for diabetic foot ulcers. It is associated with changes in quality of life, in terms of pain, self-confidence and self-esteem. The aim was to translate and adapt the OM quality of life questionnaire "OnyCOE-t-Quality Of Life Questionnaire Onychomycosis (Nail Fungal Condition)". Read More

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Genus and Its Various Human Superficial and Cutaneous Features.

Pathogens 2021 May 23;10(6). Epub 2021 May 23.

Department of Hemobiology and Blood Transfusion, 'Hassani Abdelkader' Hospital, UDL Faculty of Medecine, Sidi-Bel-Abbes 22000, Algeria.

Superficial and cutaneous aspergillosis is a rare fungal disease that is restricted to the outer layers of the skin, nails, and the outer auditory canal, infrequently invading the deeper tissue and viscera, particularly in immunocompromised patients. These mycoses are acquired through two main routes: direct traumatic inoculation or inhalation of airborne fungal spores into paranasal sinuses and lungs. Lesions are classified into three categories: otomycosis, onychomycosis, and cutaneous aspergillosis. Read More

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Coexistence of onychomycosis and nail psoriasis and its correlation with systemic treatment.

Mycoses 2021 Jun 1. Epub 2021 Jun 1.

Federal University of Rio de janeiro, Medical Clinics Department, Post graduation Course, Sector of Dermatology, Rio de Janeiro, Brazil.

Background: Epidemiological studies indicate that onychomycosis may affect up to 79% of psoriatic patients. Onychomycosis in psoriatic patients is more commonly caused by yeasts comparing with non-psoriatic.

Objectives: Evaluate the prevalence of fungi in nail psoriasis. Read More

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Common Cutaneous Infections: Patient Presentation, Clinical Course, and Treatment Options.

Med Clin North Am 2021 Jul;105(4):783-797

Department of Dermatology, University of Alabama at Birmingham, 510 20th Street South, FOT Suite 858, Birmingham, AL 35233, USA. Electronic address:

This evidence-based review highlights cutaneous infections of bacterial, viral, and fungal origin that are frequently encountered by clinicians in all fields of practice. With a focus on treatment options and management, the scope of this article is to serve as a reference for physicians, regardless of field of specialty, as they encounter these pathogens in clinical practice. Read More

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Subclinical Onychomycosis in Apparently Healthy Adults.

Skin Appendage Disord 2021 Apr 10;7(3):180-182. Epub 2021 Feb 10.

Mycology Department, Hospital General Dr. Manuel Gea González, Mexico City, Mexico.

Introduction: Onychomycosis is a frequent chronic nail infection, with a worldwide prevalence of 5.5% making it the most common nail disease, and its incidence increases with age. Clinically, it causes discoloration and thickening of the nail plate and may be accompanied by onycholysis. Read More

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Prevalence of superficial-cutaneous fungal infections in Shiraz, Iran: A five-year retrospective study (2015-2019).

J Clin Lab Anal 2021 May 24:e23850. Epub 2021 May 24.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Superficial and cutaneous fungal infections are common in tropical areas. The aim of this study was to provide a basic database of superficial and cutaneous mycoses and the most common etiological agents among patients.

Methods: Between 2015 and 2019, a total of 1807 patients suspected of superficial and cutaneous mycosis referring to the mycology laboratory of Shiraz medical school, Fars, Iran were evaluated. Read More

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Topical efinaconazole: A sequential combination therapy with oral terbinafine for refractory tinea unguium.

J Dermatol 2021 May 24. Epub 2021 May 24.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Efinaconazole is a topical antifungal drug approved in Japan for tinea unguium. Although topical treatments generally have low cure rates with a prolonged therapy period, a Cochrane review confirmed that high-quality evidence supports the effectiveness of efinaconazole for the complete cure of tinea unguium. Combination therapy is a way to improve the cure rate of onychomycosis. Read More

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Big toenail onychomycosis features associated with response to 1064 nm Nd: YAG laser treatment.

J Cosmet Dermatol 2021 May 18. Epub 2021 May 18.

Dermatology Department at Hôtel-Dieu de France Hospital, School of Medicine, Université Saint-Joseph, Beirut, Lebanon.

Background: A few studies discussed the factors correlated to response in laser treatment of onychomycosis.

Objective: This study aimed to seek big toenail onychomycosis features that correlate with response to 1064 nm Nd: YAG laser treatment.

Methods: This single-center, retrospective study included patients who had only one big toenail onychomycosis, with a confirmed mycological diagnosis and/or a high clinical suspicion. Read More

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Dermatophyte infections in children compared to adults in Germany: a retrospective multicenter study in Germany.

J Dtsch Dermatol Ges 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Venereology, and Allergology, University Medical Center Göttingen, Göttingen, Germany.

Background And Objective: Dermatophyte infections of the skin and nails are common worldwide and vary between geographical areas and over time. The aim of this study was to determine the epidemiological profile of dermatophytes in Germany with a focus on comparing children with adults.

Patients And Methods: In this retrospective multicenter study, mycological dermatophyte culture results in the period 01/2014 to 12/2016 were analyzed according to identified pathogen, age and gender of patients, and type of disease. Read More

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The role of oxidative stress in onychomycosis: Thiol/disulphide homeostasis.

Mycoses 2021 May 8. Epub 2021 May 8.

Department of Dermatology, Guglielmo Marconi University, Rome, Italy.

Objectives: Onychomycosis is the general term to define fungal nail infections that arise from dermatophytes, non-dermatophytic moulds and yeasts. Thiol/disulphide homeostasis is a new indicator of oxidative stress. In this study, we aimed to investigate the role of thiol/disulphide balance in the pathogenesis of onychomycosis. Read More

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Fungal Melanonychia as a Solitary Black Linear Vertical Nail Plate Streak: Case Report and Literature Review of Candida-Associated Longitudinal Melanonychia Striata.

Cureus 2021 Apr 1;13(4):e14248. Epub 2021 Apr 1.

Pain Management/Palliative Care, Scripps Memorial Hospital, La Jolla, USA.

Longitudinal melanonychia striata, presenting as a black linear vertical band of the nail plate, can be caused by pigmented lesions and non-pigmented etiologies. A fungal infection of the nail plate, also referred to as onychomycosis or tinea unguim, can result from dermatophytes, non-dermatophyte molds, and . Albeit rare, -associated fungal melanonychia can present as a longitudinal black nail plate streak. Read More

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Onychomycosis: New Developments in Diagnosis, Treatment, and Antifungal Medication Safety.

Shari R Lipner

Cutis 2021 Mar;107(3):113-114

Department of Dermatology, Weill Cornell Medicine, New York, New York.

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Pigmented onychomatricoma: A clinical simulator that could not mislead ultrasound.

Acta Biomed 2021 04 30;92(S1):e2021158. Epub 2021 Apr 30.

Department of Dermatology, Faculty of Medicine, University of Chile, Santiago.

Introduction: Onychomatricoma is a rare subungual tumor composed of stroma and nail matrix-like epithelium. Only seven cases of the pigmented variant have been reported in the literature.

Case Report: We present a 62-year-old male patient with a 2-years history of a single fingernail thickening, deformation, and hyperpigmentation. Read More

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Diagnosis of Onychomycosis: From Conventional Techniques and Dermoscopy to Artificial Intelligence.

Front Med (Lausanne) 2021 15;8:637216. Epub 2021 Apr 15.

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.

Onychomycosis is a common fungal nail infection. Accurate diagnosis is critical as onychomycosis is transmissible between humans and impacts patients' quality of life. Combining clinical examination with mycological testing ensures accurate diagnosis. Read More

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Toenail Psoriasis during Ustekinumab Therapy: Results and Limitations.

Ann Dermatol 2021 Apr 8;33(2):131-137. Epub 2021 Mar 8.

Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: Nail psoriasis is a common clinically significant symptom of psoriasis. However, few studies have focused on the characteristics and course of toenail psoriasis.

Objective: To investigate the treatment response of toenail psoriasis during a 52-week period of ustekinumab use. Read More

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Onychoscopy in a Colombian population with toenail onychomycosis diagnosis: an evaluating diagnostic test study.

Clin Exp Dermatol 2021 Apr 26. Epub 2021 Apr 26.

Dermatology Department, Universidad El Bosque, Bogotá, Colombia.

Onychomycosis is defined as the infection of nails caused by dermatophytes, yeasts, and non-dermatophyte molds. Fungal infections of the nail represent about 30% of all mycotic cutaneous infections and approximately 50% of all nail diseases. Onychomycosis affects between 2% to 13% of the worldwide population, with a high prevalence in adults over 70 years and recently an increased rate in the pediatric population. Read More

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Penicilliosis marneffei in HIV negative children: three case reports.

Ann Palliat Med 2021 Apr 12. Epub 2021 Apr 12.

Emergency Center of Hunan Children's Hospital, Changsha, China.

This study aimed to report the clinical characteristics of penicilliosis marneffei (PSM) in three children negative to HIV. Three children were diagnosed with PSM in the Department of Emergency Medicine, Hunan Children's Hospital between February 2016 to July 2020. The clinical characteristics, laboratory findings, and concomitant diseases were recorded, and the related literatures were reviewed. Read More

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Dermoscopic features of nail psoriasis: Positive correlation with the severity of psoriasis.

J Dermatol 2021 Jun 24;48(6):894-901. Epub 2021 Apr 24.

Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Dermoscopy is an efficient and non-invasive technique which has been widely used in the diagnosis of nail disorders including nail psoriasis (NP). Many nail dermoscopic features are considered as clues to NP. The aim of this study was to investigate specific dermoscopic features of fingernail psoriasis and the correlation between the severity of nail lesions or systemic inflammation, and psoriasis severity of skin and nail. Read More

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