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    1 OF 74

    The survey of tinea capitis and scalp dermatophyte carriage in nursing home residents.
    Med Mycol 2017 May 18. Epub 2017 May 18.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou and Taipei, Taiwan.
    Tinea capitis is a contagious dermatophyte infection of scalp and associated hairs. On the other hand, asymptomatic carriage is a status of positive dermatophyte scalp culture, but without signs or symptoms of tinea capitis, and no evidence of hair shaft invasion confirmed by direct microscopy. Tinea capitis and asymptomatic carriage mostly occur in children, but adult females are becoming another population in recent decades. Read More

    Evaluation of the Efficacy and Safety of Tavaborole Topical Solution, 5%, in the Treatment of Onychomycosis of the Toenail in Adults: A Pooled Analysis of an 8-Week, Poststudy Follow-Up From Two Randomized Phase 3 Studies.
    J Dermatolog Treat 2017 May 18:1-21. Epub 2017 May 18.
    f Oregon Dermatology and Research , Portland , OR , USA.
    Purpose: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis.

    Methods: We conducted a pooled analysis of 8-week, poststudy follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compared with placebo in adults with distal subungual onychomycosis was evaluated at week 60. Read More

    Usefulness of techniques based on real time PCR for the identification of onychomycosis-causing species.
    Mycoses 2017 May 16. Epub 2017 May 16.
    Mycology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
    Onychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT-PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Read More

    Performance of mycology and histopathology tests for the diagnosis of toenail onychomycosis due to filamentous fungi: Dermatophyte and non-dermatophyte moulds.
    Mycoses 2017 May 15. Epub 2017 May 15.
    Dermatology Departament, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. To evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. Patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. Read More

    Efinaconazole solution 10% for treatment of toenail onychomycosis in Latino patients.
    Cutis 2017 Apr;99(4):286-289
    Valeant Pharmaceuticals North America LLC, Bridgewater, New Jersey, USA.
    Onychomycosis is a common progressive fungal infection of the nail bed, matrix, or plate leading to destruction and deformity of the toenails and fingernails. The prevalence of onychomycosis is increasing in the United States, particularly in the growing population of Latino patients. In this study, we evaluated the efficacy and safety of efinaconazole solution 10% in Latino patients with onychomycosis. Read More

    Biosynthesis of zinc oxide nanoparticles by petals extract of Rosa indica L., its formulation as nail paint and evaluation of antifungal activity against fungi causing onychomycosis.
    IET Nanobiotechnol 2017 Mar;11(2):205-211
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.
    Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of Rosa indica L. (rose). Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. Read More

    Laser treatment of onychomycosis due to Neoscytalidium dimidiatum: An open prospective study.
    Med Mycol 2017 May 2. Epub 2017 May 2.
    Dermatology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Conventional systemic and topical treatments have proven ineffective for the treatment of onychomycosis caused by Neoscytalidium dimidiatum. Our aim was to evaluate the effectiveness and safety of laser monotherapy for the treatment of onychomycosis caused by this pathogen. Patients with clinical onychomycosis of the toenails and positive results both on direct mycological examination and N. Read More

    Caspofungin-Non-Susceptible Candida orthopsilosis Isolated from Onychomycosis in Iran.
    Iran J Public Health 2017 Feb;46(2):235-241
    Dept. of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species, there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied.

    Methods: We evaluated the in vitro antifungal susceptibilities of clinical isolates of C. Read More

    Evaluation of the Ability of a Novel Miconazole Formulation to Penetrate Nail Using Three Nail In Vitro Models.
    Antimicrob Agents Chemother 2017 Apr 24. Epub 2017 Apr 24.
    MedPharm Ltd, 50 Occam Road, Surrey Research Park Guildford, UK.
    In an effort to increase the efficacy of topical medications to treat onychomycosis, several new nail penetration enhancers have recently been developed. In this study, the ability of 10% w/w miconazole nitrate, combined with a penetration enhancer formulation to permeate the nail, is demonstrated by the use of a selection of in vitro nail penetration assays. These assays include bovine hoof, TurChub® zone of inhibition, and infected nail models. Read More

    High prevalence of superficial white onychomycosis by Trichophyton interdigitale in a Japanese nursing home with a geriatric hospital.
    Mycoses 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, Kanazawa Medical University, Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, Japan.
    A mycological survey on feet was performed in a nursing home with a geriatric hospital to ascertain the prevalence of tinea lesions. Of 100 subjects, comprising 62 in the nursing home and 38 in the geriatric wing, 70 were diagnosed with tinea pedis, tinea unguium (onychomycosis) or both of which 54 had onychomycosis alone, nine tinea pedis alone and seven had co-existing onychomycosis and tinea pedis. The most common clinical type of onychomycosis was distal lateral subungual onychomycosis (DLSO) at 30 cases, followed by superficial white onychomycosis (SWO) at 23 cases. Read More

    An unusually large onychomatricoma.
    BMJ Case Rep 2017 Apr 21;2017. Epub 2017 Apr 21.
    Department of Dermatology, Hospital Garcia de Orta, Almada, Portugal.
    Onychomatricoma is a rare benign tumour of the nail matrix first described in 1992, and since then, no more than 80 cases have been reported. Despite distinct clinical characteristics, it is frequently misdiagnosed as onychomycosis partly due to remaining an unknown entity. The authors present the case of a patient with a 30-year history of nail abnormalities with more recent growth to alarming dimensions. Read More

    Dermatological comorbidity in psoriasis: results from a large-scale cohort of employees.
    Arch Dermatol Res 2017 Apr 12. Epub 2017 Apr 12.
    German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. Read More

    Superficial black onychomycosis due to Neoscytalidium dimidiatum.
    J Eur Acad Dermatol Venereol 2017 Apr 12. Epub 2017 Apr 12.
    Dermatology Department, Faculty of Medicine of ABC, Santo André, SP, Brazil.
    Onychomycosis is the most common onychopathy observed in adults and the elderly, and it is a frequent reason for medical visits.(1) Its prevalence ranges from 2.0-26. Read More

    Clinical laser treatment of toenail onychomycoses.
    Lasers Med Sci 2017 Apr 4. Epub 2017 Apr 4.
    Department of Pathology and Experimental Therapeutics, Campus de Ciències de la Salut de Bellvitge, University of Barcelona, Barcelona, Spain.
    Onychomycoses are fungal infections of the fingernails or toenails having a prevalence of 3% among adults and accounts for 50% of nail infections. It is caused by dermatophytes, non-dermatophyte filamentous fungi, and yeasts. Compressions and microtraumas significantly contribute to onychomycosis. Read More

    [Mycological profile of onychomycosis in Yaoundé, Cameroon].
    J Mycol Med 2017 Mar 27. Epub 2017 Mar 27.
    Faculté de médecine et des sciences biomédicales (FMSB), B.P 8314, Yaoundé, Cameroun; Laboratoire de mycologie de la FMSB, Yaoundé, Cameroun.
    Background: The lack of data concerning the mycological spectrum of onychomycosis in Cameroon prompted us to conduct the present study, which aimed to determine the mycological profile of onychomycosis diagnosed during dermatologic consultations in Yaoundé, Cameroon.

    Methods: This was a cross-sectional study held from October 2014 to March 2015 in six hospitals of Yaoundé. Patients suspected of onychomycosis were consecutively recruited during dermatologic consultations; anamnestic and clinical data were recorded and one or several nail fragments sampled for mycological examination (direct examination or culture). Read More

    Stability of Two Antifungal Agents, Fluconazole and Miconazole, Compounded in HUMCO RECURA Topical Cream to Determine Beyond-Use Date.
    Int J Pharm Compd 2017 Mar-Apr;21(2):154-159
    HUMCO Research and Development Laboratory, Austin, Texas.
    A novel compounding vehicle (RECURA) has previously been proven to penetrate the nail bed when compounded with the antifungal agent miconazole or fluconazole, providing for an effective treatment for onychomycosis. In this study, miconazole and fluconazole were compounded separately in RECURA compounding cream, and they were tested at different time points (0, 7, 14, 28, 45, 60, 90, and 180 days) to determine the beyond-use date of those formulations. The beyond-use date testing of both formulations (10% miconazole in RECURA and 10% fluconazole in RECURA) proved them to be physically, chemically, and microbiologically stable under International Conference of Harmonisation controlled room temperature (25°C ± 2°C/60% RH ±5%) for at least 180 days from the date of compounding. Read More

    Efficacy and safety of luliconazole 5% nail solution for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.
    J Dermatol 2017 Mar 23. Epub 2017 Mar 23.
    Sato Pharmaceutical, Tokyo, Japan.
    Onychomycosis is a highly prevalent and intractable disease. The first-line treatment agents are oral preparations, but an effective topical medication has long been desired. The objective was to investigate the efficacy and safety of luliconazole 5% nail solution, an imidazole antifungal agent, for the treatment of patients with onychomycosis. Read More

    Photobiomodulation with non-thermal lasers: Mechanisms of action and therapeutic uses in dermatology and aesthetic medicine.
    J Cosmet Laser Ther 2017 Feb 17:1-9. Epub 2017 Feb 17.
    k Lorenc Aesthetic Plastic Surgery Center , New York , New York , USA.
    Background: Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light.

    Objectives: The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology.

    Methods: A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis. Read More

    A critical review of improvement rates for laser therapy used to treat toenail onychomycosis.
    J Eur Acad Dermatol Venereol 2017 Mar 13. Epub 2017 Mar 13.
    Mediprobe Research Inc., London, ON, Canada.
    Onychomycosis is a nail infection that is primary caused by dermatophytes. Alternative treatments are needed as current therapies (oral and topical antifungals) have limited effectiveness. Lasers are currently approved by the FDA to temporarily increase the amount of clear nail in onychomycosis patients. Read More

    Trans-ungual Delivery of AR-12, a Novel Antifungal Drug.
    AAPS PharmSciTech 2017 Mar 13. Epub 2017 Mar 13.
    The University of Mississippi, School of Pharmacy, University, Mississippi, USA.
    AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into and across the human nail plate followed by improving its trans-ungual permeation using different penetration enhancers. Read More

    Pathogenic Dermatophytes Survive in Nail Lesions During Oral Terbinafine Treatment for Tinea Unguium.
    Mycopathologia 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dermatology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
    Tinea unguium caused by dermatophyte species are usually treated with oral antimycotic, terbinafine (TBF). To understand the mechanisms of improvement and recalcitrance of tinea unguium by oral TBF treatment, a method of quantifying dermatophyte viability in the nail was developed, and the viability of dermatophytes was analyzed in toenail lesions of 14 patients with KOH-positive tinea unguium treated with oral TBF 125 mg/day for up to 16 weeks. Mycological tests, including KOH examination and fungal culture, and targeted quantitative real-time PCR for internal transcribed spacer (ITS) region, including rRNA, were demonstrated at the initial visit and after 8 and 16 weeks of treatment. Read More

    The Effect of Long-Pulsed Nd:YAG Laser for the Treatment of Onychomycosis.
    J Am Podiatr Med Assoc 2017 Jan;107(1):54-59
    Background: Topical onychomycosis therapies are usually inadequate, and patient compliance to systemic therapies is poor. Recently, interest in laser therapy for the treatment of onychomycosis has increased. We sought to investigate the efficacy of long-pulsed Nd:YAG laser therapy for onychomycosis. Read More

    New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation.
    J Pharm Sci 2017 Jun 3;106(6):1570-1577. Epub 2017 Mar 3.
    Research Institute for Medicine and Pharmaceutical Science, Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. Electronic address:
    Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. Read More

    Nail neoplasms.
    J Dermatol 2017 Mar;44(3):279-287
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Nail neoplasms include all tumors occurring in the nail or periungual apparatus tissue. While some nail tumors can be similar to tumors located on the skin, others are unique. Both benign and malignant lesions can affect the nail apparatus. Read More

    In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis.
    Braz J Microbiol 2017 Feb 9. Epub 2017 Feb 9.
    Universidade Federal de Juiz de Fora, Faculdade de Farmácia, Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Juiz de Fora, MG, Brazil. Electronic address:
    Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. Read More

    Accelerated nail growth rate in HIV patients.
    Int J Dermatol 2017 May 23;56(5):524-526. Epub 2017 Feb 23.
    Dermatology Department, Mycology Section, General Hospital Dr. Manuel Gea González, Mexico City, Mexico.
    Background: Many factors have been noted to alter the growth rate of both finger and toe nails, some with harder evidence than others. Infectious diseases are among the ones reported as slowing the growth rate. However, on previous studies we noticed that patients living with HIV and onychomycosis could be cured without the use of antifungal therapy, only with the immunological improvement provided by the combined antiretroviral therapy, and we wanted to prove that the growth rate is also increased in this group and thus probably contributes to the cure of onychomycosis. Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Descriptive analysis of mycological examination of patients with onychomycosis treated in private practice.
    An Bras Dermatol 2017 Jan-Feb;92(1):134-136
    Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    This is a retrospective study of 160 patients treated in private practice in São Paulo from March 2003 to March 2015. We analyzed 171 results of direct mycological examinations and fungal cultures from nail scrapings. The agreement between direct mycological examination results and fungal culture was satisfactory, consistent with the literature (kappa 0. Read More

    Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis.
    BMC Infect Dis 2017 Feb 22;17(1):166. Epub 2017 Feb 22.
    School of Microbiology, University of Antioquia (Universidad de Antioquia), Calle 67 Número 53 - 108, Bloque 5, oficina 103, Medellín, Colombia.
    Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. Read More

    The first report of onychomycosis caused by Cryptococcus friedmannii (Naganishia friedmannii) a basidiomycetous yeast.
    Med Mycol Case Rep 2017 Mar 25;15:25-27. Epub 2017 Jan 25.
    International Campus, Iran University of Medical Sciences, Tehran, Iran; Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran.
    Yeasts are common etiologic agents of onychomycosis. This study reported a case of onychomycosis due to Cryptococcus friedmannii (Naganishia friedmannii). This yeast was isolated of the right great toenail of 57-year-old man. Read More

    Topical Treatment for Onychomycosis: Is it More Effective than the Clinical Data Suggests?
    J Clin Aesthet Dermatol 2016 Nov 1;9(11):34-39. Epub 2016 Nov 1.
    Valeant Pharmaceuticals North America LLC, Bridgewater, New Jersey.
    Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consistently report secondary endpoints, making data comparison difficult. Methods: The authors review the clinical data reported on two new topical antifungals, efinaconazole and tavaborole, in light of the latest thinking of more practical approaches to assess improvement and treatment success. Read More

    Pilot study to evaluate a plasma device for the treatment of onychomycosis.
    Clin Exp Dermatol 2017 Apr 11;42(3):295-298. Epub 2017 Feb 11.
    Department of Dermatology, Weill Cornell Medical College, New York, NY, USA.
    Onychomycosis is a fungal infection of the nail unit, and is the most common of the nail disorders. Current therapies for onychomycosis have less than ideal efficacy and have the potential for adverse effects. As previous studies have shown that nonthermal plasma inhibits the in vitro growth of Trichophyton rubrum, we conducted a pilot study on 19 participants with toenail onychomycosis. Read More

    Incidence and biodiversity of yeasts, dermatophytes and non-dermatophytes in superficial skin infections in Assiut, Egypt.
    J Mycol Med 2017 Feb 7. Epub 2017 Feb 7.
    Department of Botany and Microbiology, Faculty of Science, Assiut University Mycological Centre, Assiut University, Assiut, Egypt.
    Objective: The aim was to identify the incidence of the causal agents from dermatophytes, non-dermatophytes and yeasts in Assiut Governorate employing, beside the morphological and physiological techniques, the genotypic ones.

    Patients: Samples from infected nails, skin and hair were taken from 125 patients.

    Materials And Methods: Patients who presented with onychomycosis, tinea capitis, tinea corporis, tinea cruris and tinea pedis during the period from February 2012 to October 2015 were clinically examined and diagnosed by dermatologists and were guided to Assiut University Mycological Centre for direct microscopic examination, culturing and identification. Read More

    Molecular Diagnostic Techniques for Onychomycosis: Validity and Potential Application.
    Am J Clin Dermatol 2017 Apr;18(2):281-286
    Basic Research Laboratories, Hisamitsu Pharmaceutical Co., Inc., Tsukuba, Ibaraki, Japan.
    Background: Diagnosis of onychomycosis requires positive findings by direct microscopy and fungal culture. Fungal culture is slow and difficult, with low yields. We compared two dermatophyte identification methods, one using a real-time polymerase chain reaction (PCR) method, and the other using fungal culture to validate the molecular method. Read More

    Transungual Gel of Terbinafine Hydrochloride for the Management of Onychomycosis: Formulation, Optimization, and Evaluation.
    AAPS PharmSciTech 2017 Jan 23. Epub 2017 Jan 23.
    Pharmaceutics Division, Department of Pharmaceutical Sciences, Punjabi University, Patiala, India.
    The present study was aimed to optimize, develop, and evaluate microemulsion and microemulsion-based gel as a vehicle for transungual drug delivery of terbinafine hydrochloride for the treatment of onychomycosis. D-optimal mixture experimental design was adopted to optimize the composition of microemulsion having amount of oil (X 1), Smix (mixture of surfactant and cosurfactant; X 2), and water (X 3) as the independent variables. The formulations were assessed for permeation (micrograms per square centimeter per hour; Y 1), particle size (nanometer; Y 2), and solubility of the drug in the formulation (milligrams per milliliter; Y 3). Read More

    Relationship Between Phenotypic and Genotypic Characteristics of Trichophyton mentagrophytes Strains Isolated from Patients with Dermatophytosis.
    Mycopathologia 2017 Jun 18;182(5-6):487-493. Epub 2017 Jan 18.
    Parasitology-Mycology Laboratory, Faculty of Medicine, Farhat Hached University Hospital, Mohamed El Karoui Street, 4002, Sousse, Tunisia.
    According to epidemiological, clinical and mycological criteria, it has long been admitted that the Trichophyton mentagrophytes species includes two varieties: a zoophilic variety (var. mentagrophytes) and an anthropophilic variety (var. interdigitale) that involve the upper and the lower part of the body, respectively. Read More

    Subungual squamous cell carcinoma.
    An Bras Dermatol 2016 Nov-Dec;91(6):817-819
    Policlínica Geral do Rio de Janeiro (PGRJ) - Rio de Janeiro (RJ), Brazil.
    Although subungual squamous cell carcinoma is rare, it is the most common primary malignant neoplasms in this location. The higher incidence occurs in the fingernails, but involvement of the toenails is also possible. Subungual squamous cell carcinoma often looks like other more common benign lesions, such as fungal infection, onychomycosis, or viral wart. Read More

    Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases.
    Mycoses 2017 May 18;60(5):284-295. Epub 2017 Jan 18.
    Amway Corporation, Ada, MI, USA.
    The topical treatment of nail fungal infections has been a focal point of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. Although the current focus remains on exploring the ways of enhancing permeation through the formidable nail barrier, the understanding of the nail microstructure and composition is far from complete. This article reviews our current understanding of the nail microstructure, composition and diseases. Read More

    Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review.
    Dermatol Ther 2017 Jan 18. Epub 2017 Jan 18.
    Departments of Dermatovenerology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
    The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. It showed that the experimental combination group was more effective than monotherapy of the systemic antifungals [OR (odds ratio) = 1. Read More

    An innovative polysaccharide nanobased nail formulation for improvement of onychomycosis treatment.
    Eur J Pharm Sci 2017 Mar 5;100:56-63. Epub 2017 Jan 5.
    Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil. Electronic address:
    Tioconazole-loaded nanocapsule suspensions and its coating with a cationic polymer were developed for nail drug delivery. The colloidal systems presented a nanometric size around 155nm for uncoated nanoparticles and 162nm for those with the cationic coating, with negative and positive zeta potential values, respectively. Both nanosuspensions showed drug content close to theoretical values (1mgmL(-1)), association efficiency close to 100% (HPLC) and were able to control tioconazol release. Read More

    Long-Pulsed 1064-nm Nd:YAG Laser for the Treatment of Onychomycosis.
    Photomed Laser Surg 2017 Apr 30;35(4):213-216. Epub 2016 Dec 30.
    5 Department of Health Sciences, University of Catanzaro , Catanzaro, Italy .
    Objective: The aim of this study is to evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser in penetrating tissue and targeting the fungal overgrowth in the nail plate.

    Background: Onychomycosis is the most frequent nail disorder. Current treatments include oral and topical antifungal agents, photodynamic therapy, and surgical approaches such as mechanical, chemical, or surgical nail avulsion. Read More

    Over-the-counter and natural remedies for onychomycosis: do they really work?
    Cutis 2016 Nov;98(5):E16-E25
    Department of Dermatology, Weill Cornell Medical College, New York, New York, USA.
    Onychomycosis is a fungal infection of the nail unit that may lead to dystrophy and disfigurement over time. It accounts for up to 50% of all nail conditions, with toenails affected more commonly than fingernails. Onychomycosis may affect quality of life and increase the prevalence and severity of foot ulcers in patients with diabetes. Read More

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