Search our Database of Scientific Publications and Authors

I’m looking for a

    3749 results match your criteria Onychomycosis

    1 OF 75

    Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis.
    Mycoses 2017 Sep 19. Epub 2017 Sep 19.
    Galderma International, Paris, France.
    Patient adherence is a key consideration in the choice of a topical regimen for the treatment of onychomycosis. The objective of this study was to investigate patient-reported outcomes (treatment utilisation, adherence and satisfaction) in onychomycosis treated with once-weekly amorolfine 5% nail lacquer versus once-daily ciclopirox 8% nail lacquer (Study A) or once-daily urea 40% ointment/bifonazole 1% cream combination regimen (Study B). Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks. Read More

    A pilot single centre, double blind, placebo controlled, randomized, parallel study of Calmagen® dermaceutical cream and lotion for the topical treatment of tinea and onychomycosis.
    BMC Complement Altern Med 2017 Sep 18;17(1):464. Epub 2017 Sep 18.
    Xerion Limited, Brighton, Victoria, 3186, Australia.
    Background: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis).

    Methods: A randomized, placebo-controlled, double blind, parallel, single centre study was conducted on 28 subjects with severe to very severe tinea or onychomycosis. Read More

    New insight into the pathogenesis of nail psoriasis and overview of treatment strategies.
    Drug Des Devel Ther 2017 30;11:2527-2535. Epub 2017 Aug 30.
    Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
    Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Read More

    New formulation for topical treatment of onychomycoses.
    G Ital Dermatol Venereol 2017 Oct;152(5):432-435
    Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
    Background: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient. Read More

    The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Medical Research Center, PEDEGO Research Group, University of Oulu and Oulu University Hospital, FIN-90029 OYS Oulu, Finland.
    Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. Read More

    Reversible naftifine-induced carotenoid depigmentation in Rhodotorula mucilaginosa (A. Jörg.) F.C. Harrison causing onychomycosis.
    Sci Rep 2017 Sep 11;7(1):11125. Epub 2017 Sep 11.
    Babeș-Bolyai University, Faculty of Biology and Geology, 42 Republicii Street, 400015, Cluj-Napoca, Romania.
    Rhodotorula mucilaginosa was isolated from a patient with onychomycosis, and identification was confirmed by morphological and cultural characteristics as well as by DNA molecular analysis. Antifungal agents naftifine (10 mg/mL, active substance in Exoderil) and bifonazole (10 mg/mL, active substance in Canespor) were tested in different concentrations to assess in vitro effects on fungal growth and carotenoid synthesis. The antifungal mechanisms of action of naftifine and bifonazole against R. Read More

    [Mycological profile of hand onychomycosis amongs "Garba" sellers in Abidjan (Côte d'Ivoire)].
    J Mycol Med 2017 Sep 5. Epub 2017 Sep 5.
    Laboratoire de parasitologie-mycologie-zoologie,unité de formation et de recherche des sciences pharmaceutiques et biologiques, université Félix-Houphouet-Boigny, BPV 34 Abidjan, Cote d'Ivoire; Laboratoire de parasitologie-mycologie, centre de diagnostic et de recherche sur le Sida et les autres maladies infectieuses, CHU de Treichville, 01 BPV 3 Abidjan, Cote d'Ivoire.
    Objective: The aim of this study is to determine the prevalence and the fungi involved in onychomycosis located on fingers in Abidjan.

    Material And Methods: This study includes the sellers of cooked cassava semolina served with fried tuna fish called "garba". Fines squames specimen was processed with 30% KOH for a direct microscope examination. Read More

    Onychomycosis InfectionsDo Polymerase Chain Reaction and Culture Reports Agree?
    J Am Podiatr Med Assoc 2017 Jul;107(4):280-286
    Background: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections.

    Methods: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs. Read More

    Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness.
    Skin Appendage Disord 2017 Aug 21;3(3):144-155. Epub 2017 Apr 21.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
    Purpose: Onychomycosis is the most common nail disorder and causes morbidity and impaired quality of life (QOL). Patient-reported outcomes (PRO) are patients' assessment of their health status or treatment response. PROs help assess what is most bothersome to patients to identify targets for intervention. Read More

    Prevalence of onychomycosis among patients with nail psoriasis who are not receiving immunosuppressive agents: Results of a pilot study.
    Mycoses 2017 Sep 6. Epub 2017 Sep 6.
    2nd Department of Dermatology, Faculty of Medicine, Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
    Nail psoriasis and onychomycosis can often be hard to differentiate clinically and may coexist, complicating each other's course. The aim of this study was to determine the prevalence of onychomycosis among patients with nail psoriasis not being treated with immunosuppressive agents, which constitute an independent risk factor for fungal infections. A cross-sectional study was performed. Read More

    Voriconazole-loaded nanostructured lipid carriers (NLC) for drug delivery in deeper regions of the nail plate.
    Int J Pharm 2017 Oct 30;531(1):292-298. Epub 2017 Aug 30.
    Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, 74.605-170, Goiânia, GO, Brazil. Electronic address:
    Voriconazole-loaded nanostructured lipid carriers (VOR-NLC) were developed and drug penetration evaluated in porcine hooves in vitro. Synergistic effect of urea (Ur), selected among other known chemical enhancers according to hoof hydration potential, was also evaluated. VOR-NLC presented a high encapsulation efficiency (74. Read More

    Topical antifungal treatment prevents recurrence of toenail onychomycosis following cure.
    Dermatol Ther 2017 Aug 30. Epub 2017 Aug 30.
    Mediprobe Research, Inc., London, Ontario, Canada.
    Recurrence rates are high for onychomycosis, with prophylactic topical antifungal use proposed to counter recurrence. Although this is a reasonable action for many clinicians, few studies have been conducted on the efficacy of topical prophylaxis. A retrospective chart review (2010-2015) was conducted in patients receiving oral terbinafine or itraconazole for toenail onychomycosis. Read More

    Human Infections with Microsporum gypseum Complex (Nannizzia gypsea) in Slovenia.
    Mycopathologia 2017 Aug 24. Epub 2017 Aug 24.
    University Medical Centre Ljubljana, Ljubljana, Slovenia.
    Microsporum gypseum complex is a group of geophillic dermatophytes with a worldwide distribution and is a rare cause of dermatomycoses in humans. The infection most commonly presents as tinea corporis, with some geographical and occupational variations. We studied M. Read More

    Case Report of Onychomycosis and Tinea Corporis Due to Microsporum gypseum.
    J Cutan Med Surg 2017 Aug 1:1203475417724439. Epub 2017 Aug 1.
    2 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Background: Microsporum gypseum is a geophilic dermatophyte that colonises keratinous substances in the soil. Fur-bearing animals carry this dermatophyte but are rarely infected. Human infection can be acquired from the soil, carrier or infected animals, and rarely other humans. Read More

    Utility of Boron in Dermatology.
    J Dermatolog Treat 2017 Aug 9:1-20. Epub 2017 Aug 9.
    a Department of Dermatology , Center for Dermatology Research, Wake Forest School of Medicine , Winston-Salem , North Carolina.
    Introduction: Boron compounds are being investigated as therapies for dermatologic conditions. Several features of boron chemistry make this element an ideal component in dermatologic treatments. We review the published dermatologically-relevant clinical trials and case studies pertaining to boron compounds. Read More

    Early Visible Improvements during K101-03 Treatment: An Open-Label Multicenter Clinical Investigation in Patients with Onychomycosis and/or Nail Psoriasis.
    Dermatology 2017 Aug 5. Epub 2017 Aug 5.
    Department of Experimental, Diagnostic and Specialty Medicine, Università di Bologna, Bologna, Italy.
    Introduction: Onychomycosis and nail psoriasis can be embarrassing to patients, so improving the appearance of affected nails should be one of the key short-term goals of treatment.

    Methods: An 8-week open-label multicenter study was conducted to assess whether K101-03, a marketed topical treatment containing propylene glycol, glycerol, urea, and lactic acid, could produce rapid cosmetic improvements in affected nails. Adult patients with a big toenail or thumbnail (the "target" nail) affected by onychomycosis (n = 72) or psoriasis (n = 34) or both (n = 1) applied K101-03 to their affected nails once a day for 8 weeks. Read More

    Subungual Squamous Cell Carcinoma Associated with Long Standing Onychomycosis: Aggressive Surgical Approach with a Favourable Outcome.
    Open Access Maced J Med Sci 2017 Jul 21;5(4):480-482. Epub 2017 Jul 21.
    Department of Dermatology and Allergology at the Academic Teaching Hospital Dresden-Friedrichstadt in Dresden, Germany.
    Background: Tumours of the nail bed are rare. Squamous cell carcinoma is the most frequent among them. Chronic infection, chemical or physical trauma/microtrauma, genetic disorders such as congenital ectodermal dysplasia, radiation, tar, arsenic or exposure to minerals, sun exposure, immunosuppression, and previous HPV infection have all been discussed as etiologic factors. Read More

    Epidemiology of dermatomycoses in Kerman province, southeast of Iran: A 10-years retrospective study (2004-2014).
    Microb Pathog 2017 Sep 27;110:561-567. Epub 2017 Jul 27.
    School of Medicine, Bam University of Medical Sciences, Bam, Iran.
    Objectives: Superficial and cutaneous fungal infections (SCFIs) are an important public health problem and are common in tropical and subtropical countries. Pityriasis versicolor, dermatophytosis, erythrasma, onychomycosis, and otomycosis are the major diseases associated with SCFIs. The aim of this study was to evaluate the prevalence and causative agents of dermatomycoses over a period of 10 years in Kerman province, southeast of Iran. Read More

    The increasing relevance of biofilms in common dermatological conditions.
    J Dermatolog Treat 2017 Aug 9:1-6. Epub 2017 Aug 9.
    b Department of Dermatologic Surgery and Laser Unit, St. Thomas' Hospital , St. John's Institute of Dermatology , London , UK.
    Background: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavorable conditions and antibiotics.

    Methods: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. Read More

    Highlights of Skin Disease Education Foundation's 41st Annual Hawaii Dermatology Seminar™.
    Semin Cutan Med Surg 2017 Jun;36(3S):S52-S59
    Clinical Instructor, Department of Dermatology, The University of British Columbia, Vancouver, British Columbia, Canada.
    New therapies, recent pathophysiological findings, and updated guidelines combined to create compelling presentations at the Skin Disease Education Foundation's 41st Annual Hawaii Dermatology Seminar™. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. A growing understanding of the biology of psoriasis has facilitated the development of increasingly efficacious medications. Read More

    Mycology of Onychomycosis: A 5-year retrospective review (2011 - 2015) in Hospital Kuala Lumpur.
    Med J Malaysia 2017 Jun;72(3):190-192
    Hospital Kuala Lumpur, Department of Dermatology, Malaysia.
    Onychomycosis is a common nail disease with numerous etiological pathogens. In order to determine and trend the local mycological pattern of culture-positive diseased nail samples sent from the Department of Dermatology, Hospital Kuala Lumpur, a five-year retrospective audit was carried out, which revealed that non-dermatophyte molds were the predominant fungi isolated, followed by yeasts and dermatophytes. This is similar to two previous studies in Malaysia, but varies greatly from other studies around the world which showed a dermatophyte-predominant prevalence. Read More

    [Algorithm to facilitate the management of onychomycosis].
    Rev Med Suisse 2017 Mar;13(556):698-702
    Service de dermatologie et vénéréologie, CHUV, 1011 Lausanne.
    An algorithm is proposed to facilitate the management of onychomycosis and ensure a good therapeutical approach. Its aim is to simplify the diagnosis process by integrating a pertinent anamnesis and physical examination with the classic tool of mycology (direct examination, culture, eventually examination by PCR), in order to give the adequate targeted treatment. Read More

    Oral antifungal medication for toenail onychomycosis.
    Cochrane Database Syst Rev 2017 07 14;7:CD010031. Epub 2017 Jul 14.
    Primary Care Clinical Unit, Faculty of Medicine, The University of Queensland, Level 8, Health Sciences Building 16/910, Royal Brisbane & Women's Hospital Complex, Brisbane, Herston, Queensland, Australia, 4029.
    Background: Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or applied topically; however, traditionally topical treatments have low success rates due to the nail's physical properties. Read More

    Current mycological profile of onychomycosis in Kashmir valley: A hospital-based study.
    J Lab Physicians 2017 Jul-Sep;9(3):190-194
    Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, India.
    Introduction: Onychomycosis is a common nail ailment associated with significant physical and psychological morbidity. It is caused by dermatophytes, nondermatophytic molds, and yeasts. Increased prevalence in the recent years is attributed to enhanced longevity, comorbid conditions such as diabetes, avid sports participation, and emergence of HIV. Read More

    Current antifungal treatment of fusariosis.
    Int J Antimicrob Agents 2017 Jul 10. Epub 2017 Jul 10.
    Centre of Expertise in Mycology Radboudumc/ Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
    Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and it is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Read More

    Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach.
    AAPS PharmSciTech 2017 Jul 5. Epub 2017 Jul 5.
    Drug Discovery Lab, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Opp. To Air force Station, Palaj, Gandhinagar, Gujarat, 382355, India.
    The present investigation focused on developing, optimizing, and evaluating a novel liposome-loaded nail lacquer formulation for increasing the transungual permeation flux of terbinafine HCl for efficient treatment of onychomycosis. A three-factor, three-level, Box-Behnken design was employed for optimizing process and formulation parameters of liposomal formulation. Liposomes were formulated by thin film hydration technique followed by sonication. Read More

    Epidemiological survey of dermatophytosis in Damascus, Syria, from 2008 to 2016.
    Curr Med Mycol 2016 Sep;2(3):32-36
    Department of Microbiology, Faculty of pharmacy, Arab international university (AIU), Ghabaghib, Daraa Governorate, Syria.
    Background And Purpose: It is important to follow annually the probable changes in distribution pattern of dermatophytosis and its etiological agents in different communities. In this study, we determined the prevalence of dermatophytosis and its causative agents in Damascus, Syria, between 2008 and 2016.

    Materials And Methods: A total of 4080 outpatients who visited the dermatological clinics in Damascus, were evaluated. Read More

    The first case of onychomycosis in a koala (Phascolarctos cinereus) due to atypical isolates of Microsporum gypseum, a diagnostic challenge.
    Curr Med Mycol 2016 Jun;2(2):45-50
    General Medical Education and Research Center, Teikyo University, Tokyo, Japan.
    Background And Purpose: Superficial mycotic infections have been only poorly described in koalas and there are no reliable mycologically confirmed data regarding clinical isolation of dermatophytes in this animal. We report an 11-year-old female koala, kept in a zoo in Tokyo, Japan, and presenting with hyperkeratotic lesions and scaly plaques on forepaw claws and pads reminiscent of fungal infection.

    Case Report: Direct microscopy of the scrapings was indicative of a dermatophyte infection. Read More

    A Retrospective Study of Non-thermal Laser Therapy for the Treatment of Toenail Onychomycosis.
    J Clin Aesthet Dermatol 2017 May 1;10(5):24-30. Epub 2017 May 1.
    Erchonia Corporation, Melbourne, Florida.
    Objective: The objective of this study was to assess the efficacy of non-thermal laser therapy for treating toenail onychomycosis. Design: This retrospective study analyzed the results of three nonrandomized, open-label studies. The device used was a 635nm/405nm dual-diode laser. Read More

    Genetic diversity and antifungal susceptibility of Fusarium isolates in onychomycosis.
    Mycoses 2017 Sep 28;60(9):616-622. Epub 2017 Jun 28.
    Programa de Pós-graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
    Fusarium species have emerged as an important human pathogen in skin disease, onychomycosis, keratitis and invasive disease. Onychomycosis caused by Fusarium spp. The infection has been increasingly described in the immunocompetent and immunosuppressed hosts. Read More

    Examining the importance of laboratory and diagnostic testing when treating and diagnosing onychomycosis.
    Int J Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    PharmaDerm a division of Fougera Pharmaceuticals Inc., Princeton, NJ, USA.
    Onychomycosis is a fungal nail infection caused primarily by dermatophytes. Several other nail disorders, including psoriasis, can simulate onychomycosis. Accurate diagnosis is therefore vital for the ongoing treatment and management of onychomycosis and to avoid misdiagnosis and treatment delay, which can be both lengthy and costly. Read More

    Onychomycosis in the 21st Century: An Update on Diagnosis, Epidemiology, and Treatment.
    J Cutan Med Surg 2017 Jun 1:1203475417716362. Epub 2017 Jun 1.
    3 Department of Medicine (Dermatology, Clinical Pharmacology and Toxicology) and Department of Pharmacology, Sunnybrook and Women's College Health Science Centre and the University of Toronto, Toronto, Ontario, Canada.
    Onychomycosis accounts for 50% of all nail disease cases and is commonly caused by dermatophytes. Diabetes, human immunodeficiency virus, immunosuppression, obesity, smoking, and advancing age are predisposing factors of this fungal infection. Potassium hydroxide and culture are considered the current standard for diagnosing onychomycosis, revealing both fungal viability and species identification. Read More

    Photodynamic Therapy treatment of onychomycosis with Aluminium-Phthalocyanine Chloride nanoemulsions: A proof of concept clinical trial.
    J Photochem Photobiol B 2017 Aug 8;173:266-270. Epub 2017 Jun 8.
    Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasilia, Brazil. Electronic address:
    The conventional treatment of onychomycosis, a common fungal infection, consists in the use of local and systemic drugs for 4-6 months. This long protocol is often ineffective due to patient compliance, and usually promotes important collateral effects such as liver and kidney failure. As the alternative, Photodynamic Therapy (PDT) has been used as a noninvasive alternative local treatment for onychomycosis due to the reduction of systemic side effects, fact indicates their use for patients undergoing other systemic treatments. Read More

    Hemodialysis and Kidney Transplantation as Predisposing Conditions to Onychomycosis.
    Nephron 2017 14;137(1):38-46. Epub 2017 Jun 14.
    Laboratory of Medical Mycology Unit 53, Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.
    Background/aim: Onychomycosis (OM) is one of the commonest superficial fungal infections. Patients undergoing hemodialysis (HD) treatment and kidney transplant recipients (KTR) are considered at risk of contracting fungal infections, but the few published data do not reach the conclusion of whether they are predisposed to OM. This study aimed to determine the prevalence and etiology of OM in these patients and to determine the antifungal susceptibility profile of the isolated fungal species. Read More

    Etiology of Onychomycosis in Patients, Turkey.
    J Am Podiatr Med Assoc 2017 Jun 8. Epub 2017 Jun 8.
    †† Bezmialem Vakif University Dermatoveneorology.
    Background: Onychomycosis is the chronic infection of the nails, and it is caused by dermatophytes, Candida, non- dermatophyte molds, Trichosporon genus.

    Methods: A retrospective analysis of 225 cases with onychomycosis, diagnosed in a 27-month period at the Department of Dermatoveneorology, Bezmialem Vakif University in Istanbul, and confirmed with culture.

    Results: The age of patients ranged from 2 to 87 years (41. Read More

    Onychomatricoma: A Rare and Potentially Underreported Tumor of the Nail Matrix.
    J Foot Ankle Surg 2017 Sep - Oct;56(5):1095-1098. Epub 2017 May 27.
    Residency Director, Westside Regional Medical Center, Plantation, FL.
    Onychomatricoma is a rare benign neoplasm of the nail matrix first described by Baran and Kint in 1992. Fewer than 80 cases of onychomatricoma have been described in the literature, 15 of which were initially misdiagnosed and treated as onychomycosis. We present the case of a 66-year-old male with thickening and linear xanthonychia of the hallux nail plate secondary to an onychomatricoma misdiagnosed as onychomycosis. Read More

    The efficacy of fractional carbon dioxide (CO2) laser combined with terbinafine hydrochloride 1% cream for the treatment of onychomycosis.
    J Cosmet Laser Ther 2017 Oct 30;19(6):353-359. Epub 2017 May 30.
    a Department of Dermatology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
    Background: Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. Currently, laser treatment has been studied for its efficacy in the treatment of onychomycosis. Our study was aimed to evaluate the efficacy of fractional carbon dioxide (CO2) laser treatment combined with terbinafine cream for 6 months in the treatment of onychomycosis and to analyze the influencing factors. Read More

    The survey of tinea capitis and scalp dermatophyte carriage in nursing home residents.
    Med Mycol 2017 May 18. Epub 2017 May 18.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou and Taipei, Taiwan.
    Tinea capitis is a contagious dermatophyte infection of scalp and associated hairs. On the other hand, asymptomatic carriage is a status of positive dermatophyte scalp culture, but without signs or symptoms of tinea capitis, and no evidence of hair shaft invasion confirmed by direct microscopy. Tinea capitis and asymptomatic carriage mostly occur in children, but adult females are becoming another population in recent decades. Read More

    Evaluation of the efficacy and safety of tavaborole topical solution, 5%, in the treatment of onychomycosis of the toenail in adults: a pooled analysis of an 8-week, post-study follow-up from two randomized phase 3 studies.
    J Dermatolog Treat 2017 May 30:1-5. Epub 2017 May 30.
    f Oregon Dermatology and Research , Portland , OR , USA.
    Purpose: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis.

    Methods: We conducted a pooled analysis of 8-week, post-study follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail (CN) at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compared with placebo in adults with distal subungual onychomycosis was evaluated at week 60. Read More

    Usefulness of techniques based on real time PCR for the identification of onychomycosis-causing species.
    Mycoses 2017 May 16. Epub 2017 May 16.
    Mycology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
    Onychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT-PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Read More

    Performance of mycology and histopathology tests for the diagnosis of toenail onychomycosis due to filamentous fungi: Dermatophyte and non-dermatophyte moulds.
    Mycoses 2017 Sep 15;60(9):587-593. Epub 2017 May 15.
    Dermatology Departament, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. To evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. Patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. Read More

    Efinaconazole solution 10% for treatment of toenail onychomycosis in Latino patients.
    Cutis 2017 Apr;99(4):286-289
    Valeant Pharmaceuticals North America LLC, Bridgewater, New Jersey, USA.
    Onychomycosis is a common progressive fungal infection of the nail bed, matrix, or plate leading to destruction and deformity of the toenails and fingernails. The prevalence of onychomycosis is increasing in the United States, particularly in the growing population of Latino patients. In this study, we evaluated the efficacy and safety of efinaconazole solution 10% in Latino patients with onychomycosis. Read More

    Biosynthesis of zinc oxide nanoparticles by petals extract of Rosa indica L., its formulation as nail paint and evaluation of antifungal activity against fungi causing onychomycosis.
    IET Nanobiotechnol 2017 Mar;11(2):205-211
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.
    Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of Rosa indica L. (rose). Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. Read More

    Laser treatment of onychomycosis due to Neoscytalidium dimidiatum: An open prospective study.
    Med Mycol 2017 May 2. Epub 2017 May 2.
    Dermatology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Conventional systemic and topical treatments have proven ineffective for the treatment of onychomycosis caused by Neoscytalidium dimidiatum. Our aim was to evaluate the effectiveness and safety of laser monotherapy for the treatment of onychomycosis caused by this pathogen. Patients with clinical onychomycosis of the toenails and positive results both on direct mycological examination and N. Read More

    Caspofungin-Non-Susceptible Candida orthopsilosis Isolated from Onychomycosis in Iran.
    Iran J Public Health 2017 Feb;46(2):235-241
    Dept. of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species, there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied.

    Methods: We evaluated the in vitro antifungal susceptibilities of clinical isolates of C. Read More

    Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models.
    Antimicrob Agents Chemother 2017 Jul 27;61(7). Epub 2017 Jun 27.
    MedPharm Ltd., Surrey Research Park, Guildford, United Kingdom.
    In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models. Read More

    High prevalence of superficial white onychomycosis by Trichophyton interdigitale in a Japanese nursing home with a geriatric hospital.
    Mycoses 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, Kanazawa Medical University, Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, Japan.
    A mycological survey on feet was performed in a nursing home with a geriatric hospital to ascertain the prevalence of tinea lesions. Of 100 subjects, comprising 62 in the nursing home and 38 in the geriatric wing, 70 were diagnosed with tinea pedis, tinea unguium (onychomycosis) or both of which 54 had onychomycosis alone, nine tinea pedis alone and seven had co-existing onychomycosis and tinea pedis. The most common clinical type of onychomycosis was distal lateral subungual onychomycosis (DLSO) at 30 cases, followed by superficial white onychomycosis (SWO) at 23 cases. Read More

    1 OF 75