4,642 results match your criteria Onychomycosis


The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020.

Iran J Microbiol 2022 Apr;14(2):268-275

Department of Medical Mycology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Onychomycosis is caused by dermatophyte species, non-dermatophyte moulds (NDMs), and accounts for roughly 50% of all nail diseases. As the prevalence of onychomycosis is increasing, new epidemiologic documents may help with treatment and prevention. The present investigation aims to determine the epidemiological profile of onychomycosis in 2 mycology laboratories. Read More

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MOLECULAR DETECTION OF THE TWO VIRULENCE GENES HWP1 AND ALS1 IN CANDIDA SPECIES ISOLATED FROM ONYCHOMYCOSIS.

Wiad Lek 2022 ;75(5 pt 2):1295-1298

UNIVERSITY OF THI-QAR, THI-QAR, IRAQ.

Objective: The aim: This article was aimed to assess the prevalence of Candida species causing nail infections and to investigate the most important virulence genes that cause adhesion.

Patients And Methods: Materials and methods: Samples were collected from General Hospital and the outpatient's clinics in Thi-Qar Province, southern Iraq, during the period from January 2021 to May 2021. Samples were inoculated on Sabouraud Dextrose Agar plates containing 0. Read More

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Luliconazole Nail Lacquer for the Treatment of Onychomycosis: Formulation, Characterization and In Vitro and Ex Vivo Evaluation.

AAPS PharmSciTech 2022 Jun 24;23(6):175. Epub 2022 Jun 24.

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.

Onychomycosis is the most common fungal infection of the nail affecting the skin under the fingertips and the toes. Currently, available therapy for onychomycosis includes oral and topical therapies, either alone or in combination. Oral antifungal medication has been associated with poor drug bioavailability and potential gastrointestinal and systemic side effects. Read More

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Combination of Photodynamic Therapy and Oral Antifungals for the Treatment of Onychomycosis.

Pharmaceuticals (Basel) 2022 Jun 7;15(6). Epub 2022 Jun 7.

Department of Dermatology, Miguel Servet University Hospital, IIS Aragón, Universidad de Zaragoza, 50009 Zaragoza, Spain.

Onychomycosis accounts for 50% of nail disorders, making it one of the most prevalent fungal diseases and a therapeutic challenge. Photodynamic therapy (PDT) could constitute a therapeutic alternative, owing to its good adherence, the low probability of resistance, the lack of interaction with antimicrobials, and its favorable adverse effect profile. This retrospective observational study included all patients with a microbiological diagnosis of onychomycosis treated with PDT at Miguel Servet University Hospital, Zaragoza (Spain), between January 2013 and June 2021. Read More

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Ciclopirox Hydroxypropyl Chitosan (CPX-HPCH) Nail Lacquer and Breathable Cosmetic Nail Polish: In Vitro Evaluation of Drug Transungual Permeation Following the Combined Application.

Life (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.

Background: Onychomycosis produces nail chromatic alterations that lead patients to mask them with cosmetic enamels. Objectives Evaluate drug transungual permeation and antimycotic activity against selected strains after application of CPX-HPCH nail lacquer (NL) on the nail pre-covered with breathable cosmetic polish.

Methods: CPX transungual permeation after applying CPX-HPCH NL once or twice a day on bovine hoof membranes pre-covered with a breathable cosmetic nail polish was compared to that obtained applying CPX-HPCH NL directly on the membrane. Read More

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[Suspected onychomycosis].

MMW Fortschr Med 2022 Jun;164(12):46-47

Institut für Pilzkrankheiten, mycoclinic Berlin, Luisenstr. 50, 10117, Berlin, Deutschland.

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Relevant insights into onychomycosis' pathogenesis related to the effectiveness topical treatment.

Microb Pathog 2022 Jun 15;169:105640. Epub 2022 Jun 15.

Postgraduate Program in Health Sciences, State University of Maringá (UEM), Colombo Avenue, 5790, Maringá, Paraná, 87020-900, Brazil. Electronic address:

Onychomycosis (OM) is a fungal infection, responsible for about 50% of nail diseases. OM has been attributed to the ability of fungi to naturally organize themselves into biofilms on nail surfaces. However, little is known about the exact role of the biofilm in the etiopathogenesis of OM, as well as its influence in the permeation of a topical treatment. Read More

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Increased fluconazole usage by dermatologists in the Medicare provider utilization and payment database, 2014-2019.

J Am Acad Dermatol 2022 Jun 15. Epub 2022 Jun 15.

Weill Cornell Medicine, Department of Dermatology, New York, NY, USA. Electronic address:

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Oteseconazole: First Approval.

Authors:
Sheridan M Hoy

Drugs 2022 Jun 17. Epub 2022 Jun 17.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Oteseconazole (VIVJOA™) is an orally administered azole antifungal agent developed by Mycovia Pharmaceuticals for the treatment of fungal infections. It inhibits cytochrome P450 (CYP) 51, thereby affecting the formation and integrity of the fungal cell membrane, but has a low affinity for human CYP enzymes due to its tetrazole metal-binding group. Oteseconazole is the first agent to be approved (in April 2022) for recurrent vulvovaginal candidiasis (RVVC) in the USA, where it is indicated to reduce the incidence of RVVC in females with a history of RVVC who are NOT of reproductive potential. Read More

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Potential use of microwave technology in dermatology.

J Dermatolog Treat 2022 Jun 20:1-11. Epub 2022 Jun 20.

Mediprobe Research Inc, London, Ontario, Canada.

Background: Microwaves are used in medicine for diagnostics, and treatment of cancer. Recently, novel microwave devices (Swift, Emblation Ltd, UK and miraDry, Miramar Labs Inc., CA) have been cleared by the FDA and Health Canada for various dermatological conditions. Read More

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Efficacy of Cochleated Amphotericin B in Mouse and Human Mucocutaneous Candidiasis.

Antimicrob Agents Chemother 2022 Jun 14:e0030822. Epub 2022 Jun 14.

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Candida albicans causes debilitating, often azole-resistant, infections in patients with chronic mucocutaneous candidiasis (CMC). Amphotericin B (AMB) resistance is rare, but AMB use is limited by parenteral administration and nephrotoxicity. In this study, we evaluated cochleated AMB (CAMB), a new oral AMB formulation, in mouse models of oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC) and in patients with azole-resistant CMC. Read More

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Response to Wang et al.'s "Analysis of utilization, cost and, prescription trends of onychomycosis medications among Medicare patients

J Am Acad Dermatol 2022 Jun 9. Epub 2022 Jun 9.

Medical College of Georgia, Augusta University, Department of Dermatology, 1004 Chafee Ave, Augusta GA, 30904.

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Hair and Nail Conditions: Nail Conditions.

Authors:
Julie E Mervak

FP Essent 2022 Jun;517:27-34

Department of Dermatology - University of Michigan School of Medicine, 1910 Taubman Center 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5314.

A thorough understanding of nail anatomy can help physicians identify the causes of nail conditions. Observation of changes to the nail can help establish a diagnosis. Patient evaluation should include a physical examination, dermoscopy, and, in some cases, nail biopsy. Read More

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What can GP data tell us about the treatment of onychomycosis in the UK?

Skin Health Dis 2022 Mar 16;2(1):e84. Epub 2021 Dec 16.

UCL School of Pharmacy University College London London UK.

Background: Treatment of onychomycosis is challenging, and there is much literature on optimal treatment strategies. In contrast, information on how onychomycosis is actually treated in primary care is scarce. Information on practice is important as it can reveal much, such as, to what extent national guidelines are followed and which population groups seek/receive treatment or do not do so. Read More

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Diagnosing Onychomycosis: What's New?

J Fungi (Basel) 2022 Apr 29;8(5). Epub 2022 Apr 29.

Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA.

An overview of the long-established methods of diagnosing onychomycosis (potassium hydroxide testing, fungal culture, and histopathological examination) is provided followed by an outline of other diagnostic methods currently in use or under development. These methods generally use one of two diagnostic techniques: visual identification of infection (fungal elements or onychomycosis signs) or organism identification (typing of fungal genus/species). Visual diagnosis (dermoscopy, optical coherence tomography, confocal microscopy, UV fluorescence excitation) provides clinical evidence of infection, but may be limited by lack of organism information when treatment decisions are needed. Read More

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Therapeutic application of machine learning in psoriasis: A Prisma systematic review.

J Cosmet Dermatol 2022 May 27. Epub 2022 May 27.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Dermatology, being a predominantly visual-based diagnostic field, has found itself to be at the epitome of artificial intelligence (AI)-based advances. Machine learning (ML), a subset of AI, goes a step further by recognizing patterns from data and teaches machines to automatically learn tasks. Although artificial intelligence in dermatology is mostly developed in melanoma and skin cancer diagnosis, advances in AI and ML have gone far ahead and found its application in ulcer assessment, psoriasis, atopic dermatitis, onychomycosis, etc. Read More

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Biodiversity of mycobial communities in health and onychomycosis.

Sci Rep 2022 May 25;12(1):8872. Epub 2022 May 25.

Lübeck Institute for Experimental Dermatology, Institute for Cardiogenetics, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Onychomycosis (OM) is a common fungal nail infection. Based on the rich mycobial diversity in healthy toenails, we speculated that this is lost in OM due to the predominance of a single pathogen. We used next generation sequencing to obtain insights into the biodiversity of fungal communities in both healthy individuals and OM patients. Read More

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Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers.

Int J Pharm X 2022 Dec 10;4:100118. Epub 2022 May 10.

Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, 74, 605-170 Goiânia, GO, Brazil.

This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1) were prepared. αCD was added to the surfactants dispersions to form poly(pseudo)rotaxanes (PPR). Read More

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December 2022

Epidemiology of dermatomycoses and onychomycoses in Ireland (2001-2020): A single-institution review.

Mycoses 2022 Jul;65(7):770-779

School of Medicine and Centre for Interventions in Infection, Inflammation, and Immunity (4i), University of Limerick, Limerick, Ireland.

Background: Fungal skin infections are recognised as one of the most common health disorders globally, and dermatophyte infections of the skin, hair and nails are the most common fungal infections. Dermatophytes can be classified as anthropophilic, zoophilic or geophilic species based on their primary habitat association, and this classification makes epidemiological analysis useful for the prevention and control of these infections. The Irish contribution to the epidemiology of these infections has been scant, with just two papers (both reporting paediatric tinea capitis only) published in the last 20 years, and none in the last seven. Read More

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Response surface methodological approach for optimization of photodynamic therapy of onychomycosis using chlorin e6 loaded nail penetration enhancer vesicles.

J Photochem Photobiol B 2022 Jul 5;232:112461. Epub 2022 May 5.

Pharmaceutical Nano-Technology Laboratory, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt. Electronic address:

Antimicrobial photodynamic inactivation (aPDI) has a tremendous potential as an alternative therapeutic modality to conventional antifungals in treatment of onychomycosis, yet the nail barrier properties and the deep-seated nature of fungi within the nails remain challenging. Therefore, the aim of this study was to prepare, optimize, and characterize Chorin e6 (Ce6) nail penetration enhancer containing vesicles (Ce6-nPEVs) and evaluate their photodynamic mediated effect against Trichophyton rubrum (T.rubrum); the main causative agent of onychomycosis. Read More

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Prioritization of race and ethnicity reporting and recruitment of diverse participants.

Int J Dermatol 2022 May 11. Epub 2022 May 11.

Weill Cornell Medicine, Department of Dermatology, New York, NY, USA.

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Utility of polymerase chain reaction for assessment of onychomycosis during topical therapy.

Int J Dermatol 2022 May 10. Epub 2022 May 10.

Mediprobe Research Inc., London, ON, Canada.

Background: Increased detection of fungi including non-dermatophyte molds (NDMs) using polymerase chain reaction (PCR) methods is well-established. However, the use of PCR to evaluate ongoing onychomycosis treatment outcome has not been investigated.

Methods: Nail samples from 28 patients receiving topical efinaconazole were evaluated by both KOH/culture and PCR methods across the study period. Read More

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Disinfection trials with terbinafine-susceptible and terbinafine-resistant dermatophytes.

Mycoses 2022 Jul;65(7):741-746

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Background: Treatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine-resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure. Appropriate washing reduces the risk of reinfection and is paramount in treating tinea pedis and onychomycosis. Read More

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Onychomadesis and Beau's Line Following Hand-Foot-and-Mouth Disease in a Seven-Year-Old Male.

Cureus 2022 Apr 4;14(4):e23832. Epub 2022 Apr 4.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.

Hand-foot-and-mouth disease (HFMD) is a viral infection frequently encountered in the pediatric age group. Common culprits in such manifestations are coxsackievirus A16 and human enterovirus 71. The patient presents febrile with erythematous papulovesicular exanthems in the mouth, palms, and soles. Read More

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Examination of Subungual Hematomas and Subungual Melanocytic Lesions by Using Optical Coherence Tomography and Dermoscopy.

Dermatology 2022 May 4:1-9. Epub 2022 May 4.

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Introduction: Examination of subungual pigmented lesions is sometimes a diagnostic challenge for clinicians.

Objectives: The study was aimed to investigate characteristic patterns in optical coherence tomography (OCT) of subungual hematomas and determine distinctive features that can differentiate them from subungual melanocytic lesions.

Methods: VivoSight® (Michelson Diagnostics, Maidstone, UK) was used to examine 71 subungual hematomas and 11 subungual melanocytic lesions in 69 patients (18 female and 51 male patients). Read More

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[Persistently crumbling nails in a patient with limited Dutch proficiency].

Ned Tijdschr Geneeskd 2022 03 21;166. Epub 2022 Mar 21.

Amsterdam UMC, locatie VUmc, afd. Huisartsgeneeskunde, Amsterdam.

Background: Nail psoriasis, also called psoriasis unguium, is a variant of psoriasis in which nail changes appear due to inflammation of nail bed or nail matrix. 15% to 50% of patients with cutaneous psoriasis have nail psoriasis, the condition also occurs without or before the appearance of skin lesions.

Case Description: A 54-year-old male visits his general practitioner because of crumbling of his fingernails. Read More

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Evaluating diagnostic utility of PAS stained skin scrape cytology smear in clinically suspected superficial cutaneous mycoses: A simple yet unpracticed technique.

J Family Med Prim Care 2022 Mar 10;11(3):1089-1094. Epub 2022 Mar 10.

Department of Pathology, Peoples' College of Medical Sciences and Research Centre (PCMS&RC), India.

Background And Objectives: For fungal dermatitis, a wet Potassium Hydroxide (KOH) preparation of the skin scrapings forms the routine practice for diagnosis. This study was carried out to determine the diagnostic accuracy and to evaluate the value-added information of PAS-stained scrape cytology smear in evaluating the presence of fungal elements.

Methods: This prospective study was carried out on the patients clinically diagnosed with superficial cutaneous mycoses. Read More

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Efficacy of laser therapy combined with topical antifungal agents for onychomycosis: a systematic review and meta-analysis of randomised controlled trials.

Lasers Med Sci 2022 Apr 29. Epub 2022 Apr 29.

Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, 300120, China.

Introduction: Onychomycosis is a common fungal infection of the nail. Laser and topical antifungal agent combination therapy is an emerging treatment for onychomycosis. The objective of this study was to systematically evaluate the efficacy and safety of laser and topical antifungal agent combination therapy for onychomycosis. Read More

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Onychomycosis of rare etiology.

Enferm Infecc Microbiol Clin (Engl Ed) 2022 Jun-Jul;40(6):330-331. Epub 2022 Apr 22.

Servicio de Microbiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

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Results from a Phase 1/2 trial of BB2603, a terbinafine-based topical nano-formulation, in onychomycosis and tinea pedis.

Mycoses 2022 Jun 20;65(6):661-669. Epub 2022 May 20.

Blueberry Therapeutics Limited, Macclesfield, UK.

BB2603 is a nano-formulation of the antifungal drug terbinafine with the polymer polyhexamethylene biguanide (PHMB) as an excipient to enhance solubility and drug delivery to skin and nails. BB2603 is delivered topically using a low-velocity spray. It is being developed in different strength formulations for the treatment of fungal infections of the nail and skin, including onychomycosis and tinea pedis, with BB2603-1 (0. Read More

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