4,006 results match your criteria Onychomycosis


New therapeutic options in the management of superficial fungal diseases.

Dermatol Ther 2019 Feb 12:e12855. Epub 2019 Feb 12.

Ataturk Training and Research Hospital, Dermatology Clinic, Ankara, Turkey.

Superficial fungal infections which effect the skin, hair, and nails, are widely observed in the world. Causative agents are Candida species, dermatophytes, and Malassezia species. In recent years new antifungal agents and formulations have been developed for these infections. Read More

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http://dx.doi.org/10.1111/dth.12855DOI Listing
February 2019

[Drug properties of fosravuconazole L-lysine ethanolate (NAILIN Capsules 100 mg), a new oral azole therapeutic for onychomycosis: an analysis based on non-clinical and clinical trial data].

Nihon Yakurigaku Zasshi 2019 ;153(2):79-87

Teikyo University Institute of Medical Mycology.

Ravuconazole is a fourth generation azole exerting strong antifungal activity, with low drug-drug interaction and hepatic dysfunction risks. Fosravuconazole l-lysine ethanolate (fosravuconazole; NAILIN Capsules 100 mg) was developed as a ravuconazole prodrug. Ravuconazole exerts strong antifungal activity against various pathogenic fungi including dermatophytes and Candida. Read More

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http://dx.doi.org/10.1254/fpj.153.79DOI Listing
January 2019

Demonstration of Adventitious Sporulation in Fusarium Petroliphilum Onychomycosis.

Mycopathologia 2019 Feb 8. Epub 2019 Feb 8.

Department of Microbiology, Faculty of Medicine, Kuwait University, P. O. Box 24923, 1311, Safat, Kuwait.

Fusarium petroliphilum is a recently described species within the Fusarium solani species complex. Some strains of Fusarium species are capable of forming yeast-like structures in tissue as well as in culture through a process known as "adventitious sporulation." Here, we describe the formation of these yeast-like reproductive structures in infected nail tissue obtained from a case of onychomycosis. Read More

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http://dx.doi.org/10.1007/s11046-019-0318-5DOI Listing
February 2019
1 Read

Trends in Utilization and Expenditure for Onychomycosis Treatments in the United States in 2013-2016.

Am J Clin Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Suite 1600/Dermatology, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s40257-019-00425-xDOI Listing
January 2019

Dermatophytosis caused by Nannizzia nana in two siblings.

Rev Iberoam Micol 2019 Jan 25. Epub 2019 Jan 25.

Dermatology Department and Mycology Section, "Dr. Eduardo Liceaga", General Hospital of Mexico, Mexico.

Background: Nannizzia nana is a zoophilic dermatophyte that affects animals like pigs, boars and, exceptionally, humans, in whom it causes tinea capitis, as well as tinea corporis and onychomycosis.

Case Report: Case 1. A previously healthy 8 year-old boy presented to our clinic with a 1-month evolution dermatosis that affected scalp, developing a pseudoalopecic tumor lesion with abundant seropurulent material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11301406193000
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http://dx.doi.org/10.1016/j.riam.2018.02.003DOI Listing
January 2019
3 Reads

Liquid chromatography-mass spectrometry is effective for Analysis of Ergosterol in Fungus Infected Nails.

Authors:
W-T Ho Y Li S Yang

Clin Exp Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, China.

Background: The identification of onychomycosis is mainly based on clinical diagnosis with auxiliary diagnostic methods such as KOH microscopy, PAS staining, or mold culture. However, they are limited by the sensitivity and specificity of each type of method. Therefore, our aim is to develop a new test method using the common end product - ergosterol - test to see if it can be used as a new diagnostic tool. Read More

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http://dx.doi.org/10.1111/ced.13933DOI Listing
January 2019
1 Read

Pharmacy Costs of Medications for the Treatment of Onychomycosis in the United States.

J Am Acad Dermatol 2019 Jan 25. Epub 2019 Jan 25.

Weill Cornell Medicine, Department of Dermatology, New York City, NY, USA.

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http://dx.doi.org/10.1016/j.jaad.2019.01.032DOI Listing
January 2019

Pharmacotherapy for onychomycosis: new and emerging treatments.

Authors:
Shari R Lipner

Expert Opin Pharmacother 2019 Jan 28:1-11. Epub 2019 Jan 28.

a Department of Dermatology , Weill Cornell Medicine , New York , NY , USA.

Introduction: Onychomycosis is the most common nail disorder seen in clinical practice. It is not merely an aesthetic disorder and may cause significant disability and affect the quality of life. There are no strict guidelines for onychomycosis therapy. Read More

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http://dx.doi.org/10.1080/14656566.2019.1571039DOI Listing
January 2019
1 Read

Topical ketoconazole: a systematic review of current dermatological applications and future developments.

J Dermatolog Treat 2019 Jan 22:1-12. Epub 2019 Jan 22.

a Department of Dermatology , University of California , Irvine , CA, USA.

Introduction: Although labeling changes and market withdrawal have been implemented for oral ketoconazole (KTZ) due to serious adverse effects (AEs), topical KTZ is generally thought to be effective and safe for the treatment of superficial fungal infections. New dermatologic indications for the use of topical KTZ have arisen such as onychomycosis, blepharitis, and hair loss. This article aims to review the literature on topical KTZ's efficacy and AEs, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573309DOI Listing
January 2019
1 Read

Two Cases of Proximal Subungual Onychomycosis Caused by Trichophyton rubrum in HIV-negative Patients During Treatment with TNF-α Inhibitors Combined with Methotrexate.

Acta Dermatovenerol Croat 2018 Dec;26(4):304-306

Assist. Prof. Ditte Marie L. Saunte, MD, PhD, Department of Dermatology Zealand University Hospital; Roskilde, Sygehusvej 5, DK-4000 Roskilde, Denmark;

Proximal subungual onychomycosis (PSO) is a rare subtype of onychomycosis with a clinical presentation characterized by proximal leukonychia in the lunular area of the nail. PSO is associated with immunosuppression and regarded a sign of Human Immunodeficiency Virus (HIV) infection when caused by Trichophyton (T.) rubrum. Read More

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December 2018
1 Read

Consumer Preferences of Antifungal Products for Treatment and Prevention of Tinea Pedis.

J Dermatolog Treat 2019 Jan 21:1-17. Epub 2019 Jan 21.

b Weill Cornell Medicine , Department of Dermatology , NY , NY.

Tinea pedis is a common condition seen in clinical practice and has a significant impact on quality of life. Recommendations of over-the-counter antifungal products based on consumer preferences may guide dermatologists in treating patients with tinea pedis and preventing onychomycosis recurrences. Our study aimed to determine consumer preferences of antifungal products for tinea pedis, focusing on features that may guide purchases and usage. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1572862DOI Listing
January 2019
5 Reads

Optimizing topical therapy for onychomycosis: the importance of patient education.

Cutis 2018 Dec;102(6):389-390

Duke University School of Medicine, Durham, North Carolina, USA.

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December 2018
4 Reads

Novel Point Mutations in cyp51A and cyp51B Genes Associated with Itraconazole and Posaconazole Resistance in Aspergillus clavatus Isolates.

Microb Drug Resist 2019 Jan 18. Epub 2019 Jan 18.

1 Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Aspergillus clavatus is a common environmental species known to cause occupational allergic disease in grain handlers. We have recently observed azole-resistant isolates of this fungus as a cause of onychomycosis. To further characterize the cause of resistance, the genes encoding 14 α-sterol demethylase enzyme (cyp51A and cyp51B) were characterized and analyzed in 9 ITC-susceptible isolates and 6 isolates with high minimum inhibitory concentrations (MICs) of clinical (nail and sputum) and environmental A. Read More

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https://www.liebertpub.com/doi/10.1089/mdr.2018.0300
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http://dx.doi.org/10.1089/mdr.2018.0300DOI Listing
January 2019
4 Reads
2.524 Impact Factor

Transungual Delivery of Ciclopirox Is Increased 3⁻4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model.

Pharmaceutics 2019 Jan 14;11(1). Epub 2019 Jan 14.

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. Read More

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http://dx.doi.org/10.3390/pharmaceutics11010029DOI Listing
January 2019
1 Read

Ciclopirox Hydroxypropyl Chitosan: Efficacy in Mild-to-Moderate Onychomycosis.

Skin Appendage Disord 2018 Nov 30;5(1):13-19. Epub 2018 May 30.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA.

The severity and percentage of nail involvement are usually considered the main prognostic factors for the treatment of onychomycosis. This study investigated the efficacy of P-3051 (ciclopirox [CPX] 8% nail lacquer in hydroxypropyl chitosan technology) in a population subset of the pivotal study, selected according to the criteria used in recent onychomycosis pivotal studies. The original study was a multicenter, randomized, three-arm, placebo-controlled, parallel groups, evaluator-blinded study comparing P-3051 with reference CPX (standard, insoluble 8% CPX nail lacquer) and placebo (P-3051 vehicle) in a 2: 2: 1 ratio, applied once daily for 48 weeks to 467 patients with onychomycosis, followed by a 12-week follow up. Read More

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https://www.karger.com/Article/FullText/488606
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http://dx.doi.org/10.1159/000488606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323372PMC
November 2018
3 Reads

Single-Center, Prospective, Blinded Study Comparing the Efficacy and Compatibility of Efinaconazole 10% Solution in Treating Onychomycosis with and without Concurrent Nail Polish Use.

Skin Appendage Disord 2018 Nov 25;5(1):9-12. Epub 2018 Apr 25.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Topical efinaconazole 10% solution is a promising new treatment for distal lateral subungual onychomycosis (DLSO). However, it is unknown whether this treatment is both compatible and efficacious in individuals wearing toenail polish.

Materials And Methods: We evaluated the efficacy and compatibility of efinaconazole 10% solution with concurrent nail polish use in treating DLSO over 52 weeks. Read More

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http://dx.doi.org/10.1159/000488369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323379PMC
November 2018
1 Read

Factors associated with onychomycosis in nail psoriasis: a multicenter study in Pakistan.

Int J Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Dermatology Department, Abbassi Shaheed Hospital, Karachi, Pakistan.

Background: Treatment of psoriatic nail disease is challenging, and dystrophic psoriatic nails can get secondarily infected with fungi.

Methods: This 2-year, matched case-control study was conducted at three tertiary care centers of Karachi, Pakistan. Data were collected from patients with nail psoriasis as cases with age- and gender-matched controls. Read More

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http://doi.wiley.com/10.1111/ijd.14364
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http://dx.doi.org/10.1111/ijd.14364DOI Listing
January 2019
4 Reads

Antimicrobial Photodynamic Therapy with Phenothiazinium Photosensitizers in non-vertebrate model Galleria mellonella infected with Fusarium keratoplasticum and Fusarium moniliforme.

Photodiagnosis Photodyn Ther 2018 Dec 23. Epub 2018 Dec 23.

Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040-903, Brazil. Electronic address:

Fusarium keratoplasticum and Fusarium moniliforme are filamentous fungi common in the environment and cause mycosis in both animals and plants. Human infections include mycetoma, keratitis and onychomycosis, while deeper mycosis occurs in immunocompromised patients. Most of the Fusarium spp. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183035
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http://dx.doi.org/10.1016/j.pdpdt.2018.12.010DOI Listing
December 2018
8 Reads

Global perspectives for the management of onychomycosis.

Int J Dermatol 2018 Dec 25. Epub 2018 Dec 25.

Fredric Brandt Endowed Professor of Dermatology, University of Miami, Miami, FL, USA.

Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophyte molds, and yeasts. This difficult-to-treat chronic infection has a tendency to relapse despite treatment. This paper aims to offer a global perspective on onychomycosis management from expert physicians from around the world. Read More

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http://dx.doi.org/10.1111/ijd.14346DOI Listing
December 2018

Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients.

Int J Dermatol 2018 Nov 22. Epub 2018 Nov 22.

Department of Dermatology, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Sao Paulo, Brazil.

Background: Skin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in.

Methods: 177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases. Read More

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http://dx.doi.org/10.1111/ijd.14285DOI Listing
November 2018
3 Reads

Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining.

Sci Rep 2018 Dec 14;8(1):17840. Epub 2018 Dec 14.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rules in multiple sequential data sets. Read More

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http://dx.doi.org/10.1038/s41598-018-35909-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294792PMC
December 2018
2 Reads

Polyurethanes as New Excipients in Nail Therapeutics.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Research Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal.

Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321266PMC
December 2018
1 Read

Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.

Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321522PMC
December 2018
10 Reads

Toenail alterations in chronic venous disease patients are not always of mycotic origin.

Phlebology 2018 Dec 12:268355518818619. Epub 2018 Dec 12.

1 Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Objective: The prevalence of toenail alterations in chronic venous disease has only rarely been studied. We aimed to establish the frequency and clinical characteristics of toenail onychomycosis in chronic venous disease.

Methods: We included 80 adult patients, in all stages of chronic venous disease. Read More

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http://dx.doi.org/10.1177/0268355518818619DOI Listing
December 2018
1 Read

Allergic contact dermatitis caused by undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

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http://dx.doi.org/10.1111/cod.13195DOI Listing
December 2018
4 Reads

Fusarium oxysporum is an onychomycosis etiopathogenic agent.

Future Microbiol 2018 Dec 3. Epub 2018 Dec 3.

Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá (UEM), Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil.

Aim: To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source.

Materials & Methods: The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscopy (SEM), CFU, matrix, histopathology and Fourier Transform Infrared Spectrometer coupled to an equipment with diamond accessory (FTIR-ATR).

Results: F. Read More

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http://dx.doi.org/10.2217/fmb-2018-0245DOI Listing
December 2018
1 Read

Propolis for the Treatment of Onychomycosis.

Indian J Dermatol 2018 Nov-Dec;63(6):515-517

Department of Clinical Analysis and Biomedicine, State University of Maringá, Paraná, Brazil.

Onychomycosis is a fungal nail infection, considered as a public health problem because it is contagious and it interferes with the quality of life. It has long and difficult treatment, with many side effects and high cost. Propolis extract (PE) is a potential alternative to conventional antifungal agents because it has low cost, accessibility, and low toxicity. Read More

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http://dx.doi.org/10.4103/ijd.IJD_365_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233048PMC
December 2018

Frequency of Fungal Species of Onychomycosis between Diabetic and Non-Diabetic Patients.

Mymensingh Med J 2018 Oct;27(4):752-756

Dr Sharmin Sultana, Medical Officer, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Onychomycosis is a common nail problem in our country. Diabetic patients are more prone to develop onychomycosis. Various types of fungi are the causative agents of nail infections. Read More

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October 2018
1 Read

Analysis of the role of nail polish in the transmission of onychomycosis.

An Bras Dermatol 2018 Nov/Dec;93(6):930-931

Interdisciplinary Field of Biomedical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande (RS), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20187791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256209PMC
February 2019
1 Read

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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http://dx.doi.org/10.5826/dpc.0804a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246064PMC
October 2018
3 Reads

A Comparative Study of Onychomycosis and Traumatic Toenail Onychodystrophy Dermoscopic Patterns.

J Eur Acad Dermatol Venereol 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Background: Onychomycosis (OM) and traumatic onychodystrophy (OD) are common causes of toenail changes. A clinical diagnosis is often impossible without mycology. Dermoscopy is helpful in this setting but yet under-explored. Read More

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http://dx.doi.org/10.1111/jdv.15358DOI Listing
November 2018

A survey among dermatologists: diagnostics of superficial fungal infections - what is used and what is needed to initiate therapy and assess efficacy?

J Eur Acad Dermatol Venereol 2019 Feb 13;33(2):421-427. Epub 2018 Dec 13.

Department of Dermatology, Kings College Hospital NHS Trust, London, UK.

Background: Superficial fungal infections are common. It is important to confirm the clinical diagnosis by mycological laboratory methods before initiating systemic antifungal treatment, especially as antifungal sensitivity and in vitro susceptibility may differ between different genera and species. For many years, the gold standard for diagnosis of superficial fungal infections has been direct fungal detection in the clinical specimen (microscopy) supplemented by culturing. Read More

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http://dx.doi.org/10.1111/jdv.15361DOI Listing
February 2019
9 Reads

A Practical Guide to Curing Onychomycosis: How to Maximize Cure at the Patient, Organism, Treatment, and Environmental Level.

Am J Clin Dermatol 2019 Feb;20(1):123-133

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Onychomycosis is a fungal nail infection caused by dermatophytes, non-dermatophyte molds, and yeasts. Treatment of this infection can be difficult, with relapse likely to occur within 2.5 years of cure. Read More

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http://dx.doi.org/10.1007/s40257-018-0403-4DOI Listing
February 2019
8 Reads

Mobile Phone Reminders for Onychomycosis Medication Adherence.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Weill Cornell Medicine, Department of Dermatology, NY, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.11.010DOI Listing
November 2018

Ultrasound-Enhanced Ciclopirox Delivery for Treatment of Onychomycosis.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:5717-5720

The study aim was to determine ultrasound's efficacy in increasing the permeability of the nail in order to improve treatment outcomes in onychomycosis. Three sets of ultrasound experiments were performed - the luminosity experiment and two sets of diffusion cell experiments. The luminosity experiments assessed dye levels inside the nail after ultrasound application as compared to sham treatments, and the diffusion cell experiments compared changes in nail permeability due to the application of ultrasound. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8513552DOI Listing

Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.

Mycoses 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

Background: Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. Read More

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http://dx.doi.org/10.1111/myc.12870DOI Listing
November 2018
2 Reads

Update on current approaches to diagnosis and treatment of onychomycosis.

Expert Rev Anti Infect Ther 2018 Dec 13;16(12):929-938. Epub 2018 Nov 13.

b Division of Dermatology, Department of Medicine , University of Toronto School of Medicine , Toronto , Canada.

Introduction: Onychomycosis is a chronic fungal infection of the nail bed, matrix or plate. It accounts for roughly 50% of all nail disease. As the prevalence of onychomycosis is increasing, a critical review of diagnostic techniques and treatment options is required. Read More

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http://dx.doi.org/10.1080/14787210.2018.1544891DOI Listing
December 2018

The Impact of Onychomycosis on Quality of Life: A Systematic Review of the Available Literature.

Skin Appendage Disord 2018 Oct 13;4(4):208-216. Epub 2018 Feb 13.

Mediprobe Research Inc., London, Ontario, Canada.

Purpose: Onychomycosis is a nail disorder that is increasing in prevalence worldwide. The psychological and social limitations caused by onychomycosis can potentially undermine the work and social lives of those experiencing these negative effects. This review aimed to evaluate the randomized controlled trials (RCTs) available in the current literature on the impact onychomycosis has on quality of life (QoL). Read More

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http://dx.doi.org/10.1159/000485632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219228PMC
October 2018
13 Reads

In vitro photodynamic inactivation (PDI) of pathogenic germs inducing onychomycosis.

Photodiagnosis Photodyn Ther 2018 Dec 3;24:358-365. Epub 2018 Nov 3.

Department of Physics, Humboldt-Universität zu Berlin, Newtonstraße 15, 12489, Berlin, Germany. Electronic address:

Onychomycosis is a fungal nail infection caused primarily by the dermatophytes Trichophyton rubrum and Trichophyton interdigitale or, less frequently, by molds like Aspergillus spp. and Scopulariopsis brevicaulis. Photodynamic treatment of onychomycosis is considered a promising future therapy to overcome the frequent failure of currently used antifungals. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.11.002DOI Listing
December 2018

Ultrastructural changes of Trichophyton rubrum in tinea unguium after itraconazole therapy in vivo observed using scanning electron microscopy.

Authors:
X Yue A Wang Y Sun Q Li

Clin Exp Dermatol 2018 Dec 25;43(8):883-889. Epub 2018 Jun 25.

Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Background: Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). Read More

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http://doi.wiley.com/10.1111/ced.13641
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http://dx.doi.org/10.1111/ced.13641DOI Listing
December 2018
5 Reads

Epidemiological survey of onychomycosis pathogens in Japan by real-time PCR.

Med Mycol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, Teikyo University Mizonokuchi Hospital.

In Japan, an epidemiological survey of onychomycosis pathogens was performed using culture methods; however, the positive culture rate was 40% or less. As part of an epidemiological survey of dermatomycoses in Japan, we overcame this low positive rate by employing a real-time polymerase chain reaction (PCR) assay that allowed rapid and accurate detection and identification. In 2011, nail specimens were collected from patients at nine institutes in various prefectures in Japan and diagnosed as onychomycosis. Read More

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http://dx.doi.org/10.1093/mmy/myy096DOI Listing
October 2018

Topical urea in skincare: A review.

Authors:
Leonardo Celleno

Dermatol Ther 2018 11 30;31(6):e12690. Epub 2018 Oct 30.

Catholic University of Sacred Heart, Rome, Italy.

Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Read More

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http://doi.wiley.com/10.1111/dth.12690
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http://dx.doi.org/10.1111/dth.12690DOI Listing
November 2018
8 Reads

Treatment of onychomycosis using a 1064-nm diode laser with or without topical antifungal therapy: a single-center, retrospective analysis in 56 patients.

Eur J Med Res 2018 Oct 24;23(1):53. Epub 2018 Oct 24.

Department of Dermatology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.

Background: Currently available treatment options for onychomycosis such as topical and systemic antifungals are often of limited efficacy, difficult to administer or associated with relevant side effects. Non-ablative laser therapy is proposed to represent a safe alternative without the disadvantages of drugs. Yet, to date, the efficacy of laser therapy for onychomycosis is discussed controversially. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199788PMC
October 2018
6 Reads

Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan.

J Dermatol 2018 Oct 10. Epub 2018 Oct 10.

Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14677DOI Listing
October 2018
12 Reads

Nail clipping with onychomycosis and surprise clue to the diagnosis of nail unit melanoma.

J Cutan Pathol 2018 Nov;45(11):803-806

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1111/cup.13333
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http://dx.doi.org/10.1111/cup.13333DOI Listing
November 2018
6 Reads

Case Study of Onychomycosis Patients Treated with 1,064-nm Nd:YAG Laser.

Case Rep Dermatol 2018 May-Aug;10(2):216-225. Epub 2018 Aug 31.

Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.

Onychomycosis is the most frequent nail disease, with an estimated prevalence of 2-8%. Current treatment strategies include the use of oral and topical antifungals, despite low cure rates following these treatments. The objectives of this study were to assess the therapeutic response of patients with onychomycosis to 1,064-nm Nd:YAG laser treatment, the clinical evaluation method available for this therapy, and the possible side effects of this treatment. Read More

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http://dx.doi.org/10.1159/000492526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167730PMC
August 2018
12 Reads

Ultrasound Assessment of Psoriatic Onychopathy: A Cross-sectional Study Comparing Psoriatic Onychopathy with Onychomycosis.

Acta Derm Venereol 2019 Feb;99(2):164-169

Department of Rheumatology, Hospital Universitari Parc Tauli, Sabadell, Spain.

This cross-sectional study evaluated the usefulness of an ultrasound technique in assessment of nail changes in 35 patients with psoriatic onychopathy and 25 with nail dystrophy secondary to onychomycosis. All patients underwent 3 examinations: a complete clinical assessment; a nail ultrasound study; and fungal culture. Nails of patients with psoriatic onychopathy presented a thinner nail plate and nail bed, measured by ultrasound, than did those with onychomycosis. Read More

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http://dx.doi.org/10.2340/00015555-3060DOI Listing
February 2019
1 Read

[First report of a case of fungal keratitis due to Curvularia hominis in Spain].

Rev Iberoam Micol 2018 Jul - Sep;35(3):155-158. Epub 2018 Sep 28.

Servicio de Microbiología y Parasitología, Hospital Universitario de la Princesa, Madrid, España.

Background: Dematiaceous fungal genus Curvularia is a causal agent of keratitis, onychomycosis, and skin infections. In 2014, using DNA sequencing techniques, five new species, including Curvularia hominis, were described. In this article, a report is presented on the first clinical case of C. Read More

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http://dx.doi.org/10.1016/j.riam.2018.03.004DOI Listing
September 2018
2 Reads

Coexistence of Fungal Infections in Psoriatic Nails and their Correlation with Severity of Nail Psoriasis.

Indian Dermatol Online J 2018 Sep-Oct;9(5):314-317

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Nail involvement in psoriasis is often complicated by concomitant fungal infections. The aim of this study was to investigate the prevalence of fungal infections in nail psoriasis and correlate it with the severity of nail psoriasis.

Materials And Methods: This retrospective study included patients with nail psoriasis aged ≥18 years with at least one fingernail and one toenail involvement who were treated at Siriraj Hospital from September 2012 to January 2014. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_192_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137661PMC
September 2018
13 Reads