4,271 results match your criteria Onychomycosis


Google Search Trends in Onychomycosis: Influences of Flip Flops and Advertising.

J Cosmet Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Mediprobe Research Inc, London, Ontario, Canada.

Background: Onychomycosis is a fungal infection of the nail, affecting 5.5% of the population. Individuals affected by this disease experience increased anxiety about this disorder and a decreased quality of life. Read More

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http://dx.doi.org/10.1111/jocd.13585DOI Listing

1064-nm Nd:YAG laser treatment for onychomycosis: is it worthwhile?

Lasers Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Máxima Medical Center Veldhoven, De Run 4600, P.O. Box 7777, NL-5500, MB, Veldhoven, The Netherlands.

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http://dx.doi.org/10.1007/s10103-020-03085-0DOI Listing

Epidemiology of Dermatophytoses in Switzerland According to a Survey of Dermatophytes Isolated in Lausanne between 2001 and 2018.

J Fungi (Basel) 2020 Jun 26;6(2). Epub 2020 Jun 26.

Service de Dermatologie, Laboratoire de Mycologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.

Dermatophytes are the most common pathogenic agents of superficial mycoses in humans and animals. Knowledge of their epidemiology can facilitate the prevention of dermatophytosis and improve prophylactic measures. We sought to determine the incidence of the different dermatophyte species diagnosed in Lausanne (Switzerland) from 2001 to 2018. Read More

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http://dx.doi.org/10.3390/jof6020095DOI Listing

Differences in price trends between branded and generic medications for onychomycosis.

Dermatol Ther 2020 Jun 30:e13928. Epub 2020 Jun 30.

Department of Dermatology, Weill Cornell Medicine, New York City, NY, USA.

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http://dx.doi.org/10.1111/dth.13928DOI Listing

[Mechanisms of action and clinical effectiveness of ultratonotherapy in the complex treatment of foot onychomycosis].

Vopr Kurortol Fizioter Lech Fiz Kult 2020 ;97(3):76-82

LLC «Center of laser medicine», Krasnodar, Russia.

Intruduction: A long course of onychomycosis, severe hyperkeratosis, slow growth of the nails of the feet, somatic burden, as well as an increase in the resistance of pathogens often lead to a decrease in the effectiveness of traditional antimycotics, dictating the need to create new methods of therapy. A promising direction of treatment is the use of alternating current of supratonal frequency of high voltage and low power - ultratonotherapy (UT) in combination with antifungal drugs. The article presents data on the mechanisms of action and clinical effectiveness of this method in the complex treatment of foot onychomycosis. Read More

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http://dx.doi.org/10.17116/kurort20209703176DOI Listing
January 2020

First Demonstration of Clinical Strains Causing Cross-Kingdom Infections from Humans to Plants.

Microorganisms 2020 Jun 23;8(6). Epub 2020 Jun 23.

Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Sinaloa (CIIDIR-IPN Unidad Sinaloa), Laboratorio de Fitomejoramiento Molecular, Blvd. Juan de Dios Bátiz Paredes no. 250, Col. San Joachín, C.P. 81101 Guasave, Sinaloa, Mexico.

Mycotoxins from the genus are widely known to cause economic losses in crops, as well as high mortalities rates among immunocompromised humans. However, to date, no correlation has been established for the ability of to cause cross-kingdom infection between plants and humans. The present investigation aims to fill this gap in the literature by examining cross-kingdom infection caused by strains isolated from non-immunocompromised or non-immunosuppressed humans, which were subsequently reinfected in plants and on human tissue. Read More

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http://dx.doi.org/10.3390/microorganisms8060947DOI Listing

Efficacy and safety of topical terbinafine 10% solution (MOB-015) in the treatment of mild-to-moderate distal subungual onychomycosis: A randomized, multi-center, double-blind, vehicle-controlled phase 3 study.

J Am Acad Dermatol 2020 Jun 22. Epub 2020 Jun 22.

Moberg Pharma AB (publ), Bromma, Sweden.

Background: Onychomycosis is a recalcitrant fungal nail infection. Topical antifungal agents may be preferred over systemic agents due to lack of systemic adverse events.

Objective: We investigated the efficacy and safety of topical terbinafine 10% solution (MOB-015) for the treatment of distal and lateral subungual onychomycosis (DSO). Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.055DOI Listing

Fusarium infections: Epidemiological aspects over 10 years in a university hospital in France.

J Infect Public Health 2020 Jun 21. Epub 2020 Jun 21.

Université de Lorraine, CHRU-Nancy, Laboratoire de Parasitologie Mycologie, F54000 Nancy, France; Université de Lorraine, SIMPA, F-54000 Nancy, France.

Background: Fusarium is an environmental mold that causes deep or superficial mycosis in immunocompromised or immunocompetent patients respectively.

Methods: This epidemiological study evaluated the frequency of Fusarium infections in our university hospital center in France over a decade from 2007 to 2016 and its representativeness in the main clinical infections.

Results: A total of 715 Fusarium sp. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.06.007DOI Listing

Clinical significance of Candida isolation from dystrophic fingernails.

Mycoses 2020 Jun 20. Epub 2020 Jun 20.

Department of Dermatology, Sheba Medical Center, Ramat-Gan, Israel.

Background: Candida onychomycosis mostly involves fingernails. Yet, in contrast to dermatophytes, Candida isolation from dystrophic fingernails does not prove casualty, as sample contamination and non-pathogenic Candida growth occur. Characterising treatment outcome of Candida-positive dystrophic nails is crucial to avoid unnecessary treatment. Read More

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http://dx.doi.org/10.1111/myc.13133DOI Listing

Comparison of a fractional 2940-nm Er:YAG laser and 5% amorolfine lacquer combination therapy versus a 5% amorolfine lacquer monotherapy for the treatment of onychomycosis: a randomized controlled trial.

Lasers Med Sci 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.

Onychomycosis is a fungal infection of the nail. The aim of this randomized controlled clinical trial was to compare the efficacy of 2940-nm Er:YAG laser treatment combined with a 5% amorolfine lacquer versus amorolfine monotherapy for treating onychomycosis. In this study, patients with onychomycosis of the great toenail were randomly assigned to a combination therapy group and a monotherapy group. Read More

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http://dx.doi.org/10.1007/s10103-020-03054-7DOI Listing

Noninvasive Assessment of Mycotic Nail Tissue Using an Ultraviolet Fluorescence Excitation Imaging System.

Lasers Surg Med 2020 Jun 15. Epub 2020 Jun 15.

Department of Dermatology and Wound Healing Centre, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen NV, 2400, Denmark.

Background And Objectives: Mycological diagnosis of onychomycosis is based on direct microscopy using external fluorophores to visualize fungal tissue in nail samples and agar culture. Ultraviolet fluorescence excitation imaging (u-FEI) has shown potential in monitoring biological processes by exploiting variations in autofluorescence. This study aimed at assessing the potential of a handheld u-FEI system as a practical screening tool for fungal nail infections. Read More

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http://dx.doi.org/10.1002/lsm.23285DOI Listing

Proximal subungual onychomycosis of due to .

Pan Afr Med J 2020 19;35:79. Epub 2020 Mar 19.

Department of Microbiology, Dr Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India.

Onychomycosis is a common nail infection caused by dermatophytes, non-dermatophytic molds (NDMs) and yeast. are emerging etiological agents of non-dermatophyte mold onychomycosis (NDMO). Though this is usually of cosmetic concern, it may also cause pain and discomfort to the patient. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.79.20762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250194PMC

Effect of Nail Thickness on Visible Radiation Transmittance: Implications for New Photodynamic Therapy Technologies in Onychomycosis.

Photochem Photobiol 2020 Jun 13. Epub 2020 Jun 13.

Project Engineering Area, Department of Graphic Expression Design and Projects, of Málaga, Málaga, Spain.

Photodynamic therapy is taking importance as a non-intrusive treatment for nail onychomycosis. Knowledge of true transmittance values across nails could lead to qualitative and quantitative improvements in light-based treatments. We have characterized the spectral transmittance of healthy and fungally infected human finger nails and toenails according to nail thickness and we propose a surface transmittance model for the small-scale optimization of light-based treatments. Read More

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http://dx.doi.org/10.1111/php.13296DOI Listing

Prospective, comparative evaluation of a deep neural network and dermoscopy in the diagnosis of onychomycosis.

PLoS One 2020 11;15(6):e0234334. Epub 2020 Jun 11.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Onychomycosis is the most common nail disorder and is associated with diagnostic challenges. Emerging non-invasive, real-time techniques such as dermoscopy and deep convolutional neural networks have been proposed for the diagnosis of this condition. However, comparative studies of the two tools in the diagnosis of onychomycosis have not previously been conducted. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289382PMC

Dermatologic conditions in Down syndrome: A single-center retrospective chart review.

Pediatr Dermatol 2020 Jun 10. Epub 2020 Jun 10.

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Current literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders.

Objective: We sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists.

Methods: This was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018. Read More

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http://dx.doi.org/10.1111/pde.14214DOI Listing

Antifungal efficacy of liquid poloxamer 407-based emulsions loaded with sertaconazole nitrate.

Int J Pharm 2020 Jun 5;585:119400. Epub 2020 Jun 5.

Institut für Pharmazeutische Technologie TU Braunschweig, Mendelssohnstr. 1, D-38106 Braunschweig, Germany. Electronic address:

Drug delivery into the human nail plate for the treatment of onychomycosis is difficult due to limited permeability of the nail plate. Semisolid poloxamer 407-based formulations have recently shown promising results for drug delivery into and through the nail plate. In this study, liquid poloxamer 407-based emulsions loaded with sertaconazole nitrate have been developed and the permeation behavior was determined in vitro using modified Franz diffusion cells. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119400DOI Listing

Methylene blue vs methyl aminolevulinate photodynamic therapy in combination with oral terbinafine in the treatment of severe dermatophytic toenail onychomycosis: Short- and long-term effects.

Mycoses 2020 Jun 7. Epub 2020 Jun 7.

Institute of Physical Chemistry Rocasolano, CSIC, Madrid, Spain.

Background: Photodynamic therapy (PDT) kills target microorganisms via reactive oxygen species (ROS) production. PDT seems to be a good alternative treatment option for onychomycosis.

Objective: To compare the efficacy of combined therapies based on oral terbinafine (TN) plus adjunctive PDT mediated by methylene blue (MB) (TN + MB/PDT) or methyl aminolevulinate (MAL) (TN + MAL/PDT) in the treatment of onychomycosis. Read More

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http://dx.doi.org/10.1111/myc.13125DOI Listing

Co-delivery of terbinafine hydrochloride and urea with an in situ film-forming system for nail targeting treatment.

Int J Pharm 2020 Jun 3;585:119497. Epub 2020 Jun 3.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

Onychomycosis is a chronic nail disorder consisting of a fungal infection that causes physical and psychosocial discomfort to patients. However, its treatment remains challenging owing to the barrier of the highly keratinized nail plate and the short time that conventional formulations reside on nails. In this work, we developed an in situ film-forming system(IFFS) based on Eudragit® RLPO to co-deliver terbinafine hydrochloride (TBH) and urea, i. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119497DOI Listing

Impact of Onychomycosis and Treatment on Patient Reported Quality of Life Outcomes: A Systematic Review.

J Am Acad Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:

Background: Onychomycosis is the most common nail disorder, often causing physical, emotional, and aesthetic consequences. The impact of both the condition itself and treatment on quality of life has not been well studied.

Objective: The objectives of this study were to systematically review the available literature describing the impact of onychomycosis and treatment on quality of life. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.143DOI Listing
June 2020
4.449 Impact Factor

Breaking the Terbinafine Laboratory Habit for Onychomycosis.

Authors:
Warren R Heymann

Skinmed 2020 1;18(2):115-116. Epub 2020 Mar 1.

Division of Dermatology, Departments of Medicine and Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;

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Onychomatricoma Presenting as a Dystrophic Right Great Toenail: Case Report and Review.

Cureus 2020 May 3;12(5):e7946. Epub 2020 May 3.

Dermatology, San Diego Family Dermatology, National City, USA.

Onychomatricoma is a rare, benign nail matrix tumor. It most frequently occurs on one of the first three fingers of the dominant hand or the big toe in middle-aged women. Our patient presented with a 10-year history of a progressive thickening of her right great toenail; it bled easily and was intermittently painful. Read More

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http://dx.doi.org/10.7759/cureus.7946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268579PMC

Dermoscopic findings of fungal melanonychia.

Postepy Dermatol Alergol 2020 Apr 5;37(2):180-183. Epub 2020 May 5.

Department of Dermatology and Venereology, Batman Medical Park Hospital, Batman, Turkey.

Introduction: There are very few studies about dermoscopic findings of fungal melanonychia (FM) apart from the case reports.

Aim: To reveal and identify dermoscopic findings which facilitate diagnosis of the FM.

Material And Methods: The study included a total of 42 nails from 33 patients diagnosed with FM on the basis of the clinical history, physical examination, dermoscopic findings and microbiological investigation. Read More

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http://dx.doi.org/10.5114/ada.2020.94836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262796PMC

The Impact of Onychopathies on Quality of Life: A Hospital-based, Cross-sectional Study.

Indian Dermatol Online J 2020 Mar-Apr;11(2):187-194. Epub 2020 Mar 9.

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Background: Onychopathies or nail disorders are associated with social stigma and causes limitation of daily activities by hampering the function of both fingers and toes.

Aim: To evaluate the impact of onychopathies on quality of life (QoL) and compare the severity of impact on QoL in various nail disorders.

Materials And Methods: A hospital-based cross-sectional study consisting of 540 patients with onychopathies was conducted in the dermatology outpatient department. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_272_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247629PMC

Intra-Operative Dermoscopy in Assessment of Melanonychia and as a Guide for Biopsy.

Indian Dermatol Online J 2020 Mar-Apr;11(2):171-176. Epub 2020 Mar 9.

Department of Pathology, ESI-PGIMSR Hospital, Basaidarapur, Delhi, India.

Background And Aims: Melanonychia can be a manifestation of benign or malignant pathology and often poses a diagnostic challenge on clinical examination. Even with distinguishing dermoscopic features (nail plate), it can be quite difficult to determine the nature of pigmentation as complete assessment of nail bed and matrix is still not possible. Intraoperative dermoscopy (IOD) can serve as a useful tool to appreciate the bed and matrix changes. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_94_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247626PMC

Non-dermatophyte Mould Onychomycosis in Japan.

Med Mycol J 2020 ;61(2):23-31

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University.

The incidence of non-dermatophyte mould onychomycosis has been increasing worldwide for the past several decades, but it is not well recognized in Japan. Recent molecular techniques and phylogenetic analyses contributed to the identification of uncommon and emerging species. We came across 13 (0. Read More

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http://dx.doi.org/10.3314/mmj.20-00007DOI Listing
January 2020

Usefulness of Wood's Lamp for the Diagnosis and Treatment Follow-up of Onychomycosis.

Med Mycol J 2020 ;61(2):17-21

Department of Pathology, Teikyo University Chiba Medical Center.

Wood's lamp was demonstrated to be useful in three cases of dermatophytoma treated during clinical dermatological practice. Clinical signs of onychomycosis are longitudinal yellow and white striae on the nail plate and are diagnosed by KOH direct microscopic examination. For its treatment, surgical debridement is recommended. Read More

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http://dx.doi.org/10.3314/mmj.20-00004DOI Listing
January 2020

Recommendations for diagnosis and treatment of onychomycosis during the COVID-19 pandemic.

Dermatol Ther 2020 May 30:e13709. Epub 2020 May 30.

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

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http://dx.doi.org/10.1111/dth.13709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300483PMC

Methylene blue mediated antimicrobial photodynamic therapy in clinical human studies: The state of the art.

Photodiagnosis Photodyn Ther 2020 May 27:101828. Epub 2020 May 27.

Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho/UNINOVE, 249 Vergueiro Street, Liberdade, São Paulo, SP, 01504-001, Brazil. Electronic address:

Background: The goals of this study were to update the information about aPDT when using methylene blue (MB) for the treatment of human clinical infections of different etiologies, except for dentistry applications, and to investigate the best parameters of MB to achieve this.

Methods: This study was a systematic literature review performed according to the PRISMA guidelines. A literature search was performed for studies with adult human patients (>18 years-old) published in the English, French, Spanish, Portuguese, and Italian languages when using the electronic databases of MEDLINE, Embase, OpenGrey, and LILACS. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101828DOI Listing

Trends in onychomycosis prescribing: a single center retrospective study over 15 years.

J Dermatolog Treat 2020 Jun 4:1-2. Epub 2020 Jun 4.

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1080/09546634.2020.1774040DOI Listing

Keratin Biomembranes as a Model for Studying Onychomycosis.

Int J Mol Sci 2020 May 15;21(10). Epub 2020 May 15.

Department of Chemical Engineering, Ariel University, Kyriat-ha-Mada, Ariel 4070000, Israel.

Difficulties in obtaining human nails that are large enough for examining the penetration of drug formulations led us to produce keratin films regenerated from human hair. We assume that these films can simulate human nail plates in drug penetration and permeation tests and can serve as a biological model for studying onychomycosis. The films were formed from keratin extracted from human hair using dithiothreitol, urea and thiourea. Read More

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http://dx.doi.org/10.3390/ijms21103512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278978PMC

A Phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of VT-1161 oral tablets in the treatment of patients with distal and lateral subungual onychomycosis of the toenail.

Br J Dermatol 2020 May 18. Epub 2020 May 18.

Viamet Pharmaceuticals Inc, Durham, North Carolina, USA.

Background: Onychomycosis is a fungal disease that affects the fingernails and toenails and is predominantly caused by dermatophytes. VT-1161 is a novel inhibitor of fungal CYP51 through the inhibition of the lanosterol demethylase, and has demonstrated potent activity against T. rubrum and T. Read More

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http://dx.doi.org/10.1111/bjd.19224DOI Listing

Molecular characterization of fungi causing colonization and infection in organ transplant recipients: A one-year prospective study.

Curr Med Mycol 2020 ;6(1):30-35

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background And Purpose: Organ transplant recipients are vulnerable to fungal infections. The aim of this study was to determine the prevalence of fungal colonization and infections among patients who underwent various transplantations and molecularly characterize the etiological agents.

Materials And Methods: This study was conducted on candidates for transplantation in Imam Khomeini Hospital, Tehran, Iran, from April 2017 to April 2018. Read More

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http://dx.doi.org/10.18502/cmm.6.1.2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217253PMC
January 2020

Translation elongation factor 1-alpha gene as a marker for diagnosing of candidal onychomycosis.

Curr Med Mycol 2020 ;6(1):15-21

Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Purpose: Culture-based identification methods have been the gold standard for the diagnosis of candidal onychomycosis. Molecular technologies, such as polymerase chain reaction (PCR) assays, can provide an alternative for the rapid detection of species. The present study was conducted to investigate a pan- PCR assay based on the translation elongation factor 1-alpha () gene for the detection of the most prevalent pathogenic species. Read More

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http://dx.doi.org/10.18502/cmm.6.1.2503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217255PMC
January 2020

Fractional CO-assisted photodynamic therapy improves the clinical outcome and patient's satisfaction in toenail onychomycosis treatment: an intra-patient comparative single-center study.

J Dermatolog Treat 2020 Jun 23:1-8. Epub 2020 Jun 23.

Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Device-based therapies have been used for onychomycosis patients with intolerance to systemic treatments. Photodynamic therapy (PDT) improves onychomycosis, while fractional carbon dioxide (FrCO) augments the topical drug delivery. Comparative studies between PDT alone and laser-assisted one are lacking. Read More

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http://dx.doi.org/10.1080/09546634.2020.1771252DOI Listing

Labelled use of efinaconazole topical solution 10% in treating onychomycosis in children and a review of the management of pediatric onychomycosis.

Dermatol Ther 2020 May 17:e13613. Epub 2020 May 17.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Until recently, there was no FDA-approved antifungal treatment for onychomycosis in children. There is evidence regarding the safety and efficacy of topical antifungal agents for pediatric onychomycosis.

Objective: To summarize the results of a recent study using efinaconazole 10% solution to treat onychomycosis in children and discuss the management of pediatric onychomycosis. Read More

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http://dx.doi.org/10.1111/dth.13613DOI Listing

Use of MALDI-TOF MS for fungal species distribution of interdigital intertrigo in seafarers, Dakar, Senegal.

J Mycol Med 2020 Apr 21:100974. Epub 2020 Apr 21.

Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, BP 5005, Dakar, Senegal; Service de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie, université Cheikh Anta Diop, BP 16477, Dakar, Senegal.

To determine fungal species distribution of interdigital intertrigo among seafarers in Dakar, Senegal, a cross-sectional study was carried out from May to August 2017 among seafarers clinically diagnosed with interdigital intertrigo. A questionnaire was filled to each patient before sampling the affected folds and transporting to Aristide Le Dantec University Hospital where mycological analyses were realized. Species identification by MALDI-TOF MS was performed in Marseille, France. Read More

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http://dx.doi.org/10.1016/j.mycmed.2020.100974DOI Listing

Nail dermoscopy (onychoscopy) findings in the diagnosis of primary onychomycosis: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2020 Jul-Aug;86(4):341-349

Department of Pathology, University College of Medical Sciences and GTB Hospital (University of Delhi), Delhi, India.

Background: Diagnosis of onychomycosis involves direct microscopic examination with potassium hydroxide, culture or histopathology with periodic acid-Schiff staining. Nail dermoscopy (onychoscopy) is a noninvasive, rapid and easily available diagnostic tool though its utility in onychomycosis remains unexplored.

Objective: To describe the various onychoscopic patterns and compare its percentage positivity with that of standard potassium hydroxide examination, culture and histopathology in patients with a clinical diagnosis of onychomycosis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_100_19DOI Listing
May 2020
1.325 Impact Factor

Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy.

Dermatol Res Pract 2020 2;2020:7209518. Epub 2020 May 2.

Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.

Psoriasis and psoriatic arthritis are chronic, relapsing, immune-based diseases. Psoriatic patients may have nail involvement in 50 to 80% of cases, and this may reach 85% in patients with joint disease, in spite of the fact that the relationship between psoriasis and onychomycosis is not well established. The aim of this study was to investigate the occurrence of onychomycosis in patients with nail disorders and diagnosis of psoriasis and psoriatic arthritis. Read More

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http://dx.doi.org/10.1155/2020/7209518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212309PMC

Visualisation of penetration of topical antifungal drug substances through mycosis-infected nails by matrix-assisted laser desorption ionisation mass spectrometry imaging.

Mycoses 2020 May 14. Epub 2020 May 14.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Matrix-assisted laser desorption ionisation mass spectrometry imaging (MALDI-MSI) is a mass spectrometry-based technique, which can be applied for compound-specific imaging of pharmaceuticals in tissues samples. MALDI-MSI technology is widely used to visualise penetration and distribution profile through different tissues but has never been used with nail tissue.

Objectives: This study used MALDI-MSI technology to visualise distribution profile and penetration into ex vivo human mycosis-infected toenails of three antifungal active ingredients amorolfine, ciclopirox and naftifine contained in topical onychomycosis nail treatment preparations, marketed as Loceryl , Ciclopoli and Exoderil . Read More

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http://dx.doi.org/10.1111/myc.13103DOI Listing

Retrospective Analysis of Laboratory Abnormalities in Patients Prescribed Terbinafine for Onychomycosis.

J Am Acad Dermatol 2020 May 6. Epub 2020 May 6.

Weill Cornell Medicine, Department of Dermatology, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.172DOI Listing

Morphological and Transcriptome Analyses Provide Insights into Growth Inhibition of Caused by Laser Irradiation.

Evid Based Complement Alternat Med 2020 16;2020:6052461. Epub 2020 Apr 16.

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

is one of the most common types of dermatophyte, causing superficial skin mycosis in human populations. Although laser treatment of onychomycosis has been proven to be effective in the clinic, the underlying mechanism of the effect of the laser on fungal growth is not clear. The objective of the present study was to observe the ultrastructural changes of following laser irradiation and compare the transcriptome differences between the laser irradiation group and control group. Read More

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http://dx.doi.org/10.1155/2020/6052461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182975PMC

Retrospective Study of Factors Affecting Medication Adherence in Patients Prescribed Efinaconazole 10% Solution for Onychomycosis.

J Am Acad Dermatol 2020 Apr 30. Epub 2020 Apr 30.

Department of Dermatology, Weill Cornell Medicine, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.126DOI Listing

Photodynamic therapy treatment of superficial fungal infections: a systematic review.

Photodiagnosis Photodyn Ther 2020 Apr 24:101774. Epub 2020 Apr 24.

Department of Dermatology, Zealand University Hospital, Sygehusvej 5, DK-4000, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark; Unit of Mycology, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, Denmark. Electronic address:

Background: Fungal infections in skin, hair and nails affect up to 25% of the global population. Conventional antifungal treatment is effective but due to resistance, treatment failure, drug interactions, and treatment related toxicity, there is a need for alternative treatments. Photodynamic therapy (PDT) has shown antimicrobial properties and is used increasingly for fungal infections. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101774DOI Listing

Kodamaea ohmeri infections in humans: A systematic review.

Mycoses 2020 Jul 6;63(7):636-643. Epub 2020 May 6.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, belongs to the Saccharomycetaceae family and the Ascomycetae class, is the telomorphic form of C guilliermondii var. membranaefaciens and is frequently mistaken for Candida, as they belong to the same family. It has been isolated from environmental sources, such as sand, pools, seawater and fruits, while the last decades it is recognised as a rare pathogen that causes life-threatening infections in humans. Read More

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http://dx.doi.org/10.1111/myc.13094DOI Listing

Benefits of Teledermatology for Geriatric Patients: Population-Based Cross-Sectional Study.

J Med Internet Res 2020 Apr 21;22(4):e16700. Epub 2020 Apr 21.

Telemedicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: Teledermatology is a health care tool that has been increasingly used around the world, mostly because dermatology has an emphasis on visual diagnosis. Many studies have shown that access to specialized care improves using teledermatology, which provides accurate diagnosis and reduces the time taken for treatment, with high patient satisfaction. As the population around the world grows old, there will be even more demand for dermatologists in years to come. Read More

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http://dx.doi.org/10.2196/16700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201316PMC

Comparative Study of Traditional Ablative CO Laser-Assisted Topical Antifungal with only Topical Antifungal for Treating Onychomycosis: A Multicenter Study.

Clin Drug Investig 2020 Jun;40(6):575-582

Department of Dermatology and Venereology, Shanghai Tongji Hospital, Tongji University School of Medicine, 398 Xincun road, Putou District, Shanghai, China.

Background: The predominance of onychomycosis has been increasing recently. New medications and treatment modalities are being researched for better saturation of the antifungal agents through the nail plate topically because of the low resilience of some patients for the oral antifungal agents. Treatment of onychomycosis, mainly moderate to severe, can be very challenging, expensive, and time consuming. Read More

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http://dx.doi.org/10.1007/s40261-020-00914-6DOI Listing
June 2020
1.704 Impact Factor

In vitro antifungal susceptibility testing of fungi in patients with onychomycosis.

Dermatol Ther 2020 May 8;33(3):e13429. Epub 2020 May 8.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Onychomycosis is the most common nail disorder. To examine in vitro antifungal susceptibility of fungi among onychomycosis patients. The study included 68 patients with onychomycosis. Read More

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http://dx.doi.org/10.1111/dth.13429DOI Listing
May 2020
1.478 Impact Factor

Level of trace elements in serum and toenail samples of patients with onychocryptosis (ingrown toenail) and onychomycosis.

J Trace Elem Med Biol 2020 Mar 30;61:126509. Epub 2020 Mar 30.

Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Kocamustafapaşa Cad. No: 34/E Fatih, Istanbul, Turkey.

Background: Onychocryptosis (ingrown toenail) and onychomycosis are common pathologies of the toenail and affecting many people. Since levels of trace elements have been shown to vary in certain diseases, in the presented work, chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), selenium (Se), and zinc (Zn) levels of toenail and serum samples of healthy individuals and patients with onychocryptosis and onychomycosis were compared.

Methods: Serum and toenail samples of 88 voluntary subjects (healthy n = 24; onychomycosis n = 24; onychocryptosis n = 40) aged between 19-80 years were collected. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126509DOI Listing