SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis.
- Tais Gratieri,
- Anna Paula Krawczyk-Santos,
- Priscila Bianca Rodrigues da Rocha,
- Marcilio Cunha-Filho,
- Guilherme Martins Gelfuso,
- Ricardo Neves Marreto,
- Stephania Fleury Taveira
Curr Pharm Des 2017 Nov 14. Epub 2017 Nov 14.
Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goias, Rua 240, esq. com 5ª Avenida, Setor Leste Universitario, 74605-170, Goiania, GO. Brazil.
Background: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. Read More