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    [Algorithm to facilitate the management of onychomycosis].
    Rev Med Suisse 2017 Mar;13(556):698-702
    Service de dermatologie et vénéréologie, CHUV, 1011 Lausanne.
    An algorithm is proposed to facilitate the management of onychomycosis and ensure a good therapeutical approach. Its aim is to simplify the diagnosis process by integrating a pertinent anamnesis and physical examination with the classic tool of mycology (direct examination, culture, eventually examination by PCR), in order to give the adequate targeted treatment. Read More

    Oral antifungal medication for toenail onychomycosis.
    Cochrane Database Syst Rev 2017 Jul 14;7:CD010031. Epub 2017 Jul 14.
    Primary Care Clinical Unit, Faculty of Medicine, The University of Queensland, Level 8, Health Sciences Building 16/910, Royal Brisbane & Women's Hospital Complex, Brisbane, Herston, Queensland, Australia, 4029.
    Background: Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or applied topically; however, traditionally topical treatments have low success rates due to the nail's physical properties. Read More

    Current mycological profile of onychomycosis in Kashmir valley: A hospital-based study.
    J Lab Physicians 2017 Jul-Sep;9(3):190-194
    Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, India.
    Introduction: Onychomycosis is a common nail ailment associated with significant physical and psychological morbidity. It is caused by dermatophytes, nondermatophytic molds, and yeasts. Increased prevalence in the recent years is attributed to enhanced longevity, comorbid conditions such as diabetes, avid sports participation, and emergence of HIV. Read More

    Current antifungal treatment of fusariosis.
    Int J Antimicrob Agents 2017 Jul 10. Epub 2017 Jul 10.
    Centre of Expertise in Mycology Radboudumc/ Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
    Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and it is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Read More

    Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach.
    AAPS PharmSciTech 2017 Jul 5. Epub 2017 Jul 5.
    Drug Discovery Lab, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Opp. To Air force Station, Palaj, Gandhinagar, Gujarat, 382355, India.
    The present investigation focused on developing, optimizing, and evaluating a novel liposome-loaded nail lacquer formulation for increasing the transungual permeation flux of terbinafine HCl for efficient treatment of onychomycosis. A three-factor, three-level, Box-Behnken design was employed for optimizing process and formulation parameters of liposomal formulation. Liposomes were formulated by thin film hydration technique followed by sonication. Read More

    Epidemiological survey of dermatophytosis in Damascus, Syria, from 2008 to 2016.
    Curr Med Mycol 2016 Sep;2(3):32-36
    Department of Microbiology, Faculty of pharmacy, Arab international university (AIU), Ghabaghib, Daraa Governorate, Syria.
    Background And Purpose: It is important to follow annually the probable changes in distribution pattern of dermatophytosis and its etiological agents in different communities. In this study, we determined the prevalence of dermatophytosis and its causative agents in Damascus, Syria, between 2008 and 2016.

    Materials And Methods: A total of 4080 outpatients who visited the dermatological clinics in Damascus, were evaluated. Read More

    The first case of onychomycosis in a koala (Phascolarctos cinereus) due to atypical isolates of Microsporum gypseum, a diagnostic challenge.
    Curr Med Mycol 2016 Jun;2(2):45-50
    General Medical Education and Research Center, Teikyo University, Tokyo, Japan.
    Background And Purpose: Superficial mycotic infections have been only poorly described in koalas and there are no reliable mycologically confirmed data regarding clinical isolation of dermatophytes in this animal. We report an 11-year-old female koala, kept in a zoo in Tokyo, Japan, and presenting with hyperkeratotic lesions and scaly plaques on forepaw claws and pads reminiscent of fungal infection.

    Case Report: Direct microscopy of the scrapings was indicative of a dermatophyte infection. Read More

    A Retrospective Study of Non-thermal Laser Therapy for the Treatment of Toenail Onychomycosis.
    J Clin Aesthet Dermatol 2017 May 1;10(5):24-30. Epub 2017 May 1.
    Erchonia Corporation, Melbourne, Florida.
    Objective: The objective of this study was to assess the efficacy of non-thermal laser therapy for treating toenail onychomycosis. Design: This retrospective study analyzed the results of three nonrandomized, open-label studies. The device used was a 635nm/405nm dual-diode laser. Read More

    Genetic diversity and antifungal susceptibility of Fusarium isolates in onychomycosis.
    Mycoses 2017 Jun 28. Epub 2017 Jun 28.
    Programa de Pós-graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
    Fusarium species have emerged as an important human pathogen in skin disease, onychomycosis, keratitis and invasive disease. Onychomycosis caused by Fusarium spp. The infection has been increasingly described in the immunocompetent and immunosuppressed hosts. Read More

    Examining the importance of laboratory and diagnostic testing when treating and diagnosing onychomycosis.
    Int J Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    PharmaDerm a division of Fougera Pharmaceuticals Inc., Princeton, NJ, USA.
    Onychomycosis is a fungal nail infection caused primarily by dermatophytes. Several other nail disorders, including psoriasis, can simulate onychomycosis. Accurate diagnosis is therefore vital for the ongoing treatment and management of onychomycosis and to avoid misdiagnosis and treatment delay, which can be both lengthy and costly. Read More

    Onychomycosis in the 21st Century: An Update on Diagnosis, Epidemiology, and Treatment.
    J Cutan Med Surg 2017 Jun 1:1203475417716362. Epub 2017 Jun 1.
    3 Department of Medicine (Dermatology, Clinical Pharmacology and Toxicology) and Department of Pharmacology, Sunnybrook and Women's College Health Science Centre and the University of Toronto, Toronto, Ontario, Canada.
    Onychomycosis accounts for 50% of all nail disease cases and is commonly caused by dermatophytes. Diabetes, human immunodeficiency virus, immunosuppression, obesity, smoking, and advancing age are predisposing factors of this fungal infection. Potassium hydroxide and culture are considered the current standard for diagnosing onychomycosis, revealing both fungal viability and species identification. Read More

    Photodynamic Therapy treatment of onychomycosis with Aluminium-Phthalocyanine Chloride nanoemulsions: A proof of concept clinical trial.
    J Photochem Photobiol B 2017 Jun 8;173:266-270. Epub 2017 Jun 8.
    Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasilia, Brazil. Electronic address:
    The conventional treatment of onychomycosis, a common fungal infection, consists in the use of local and systemic drugs for 4-6 months. This long protocol is often ineffective due to patient compliance, and usually promotes important collateral effects such as liver and kidney failure. As the alternative, Photodynamic Therapy (PDT) has been used as a noninvasive alternative local treatment for onychomycosis due to the reduction of systemic side effects, fact indicates their use for patients undergoing other systemic treatments. Read More

    Hemodialysis and Kidney Transplantation as Predisposing Conditions to Onychomycosis.
    Nephron 2017 Jun 14. Epub 2017 Jun 14.
    Laboratory of Medical Mycology Unit 53, Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.
    Background/aim: Onychomycosis (OM) is one of the commonest superficial fungal infections. Patients undergoing hemodialysis (HD) treatment and kidney transplant recipients (KTR) are considered at risk of contracting fungal infections, but the few published data do not reach the conclusion of whether they are predisposed to OM. This study aimed to determine the prevalence and etiology of OM in these patients and to determine the antifungal susceptibility profile of the isolated fungal species. Read More

    Etiology of Onychomycosis in Patients, Turkey.
    J Am Podiatr Med Assoc 2017 Jun 8. Epub 2017 Jun 8.
    †† Bezmialem Vakif University Dermatoveneorology.
    Background: Onychomycosis is the chronic infection of the nails, and it is caused by dermatophytes, Candida, non- dermatophyte molds, Trichosporon genus.

    Methods: A retrospective analysis of 225 cases with onychomycosis, diagnosed in a 27-month period at the Department of Dermatoveneorology, Bezmialem Vakif University in Istanbul, and confirmed with culture.

    Results: The age of patients ranged from 2 to 87 years (41. Read More

    Onychomatricoma: A Rare and Potentially Underreported Tumor of the Nail Matrix.
    J Foot Ankle Surg 2017 May 27. Epub 2017 May 27.
    Residency Director, Westside Regional Medical Center, Plantation, FL.
    Onychomatricoma is a rare benign neoplasm of the nail matrix first described by Baran and Kint in 1992. Fewer than 80 cases of onychomatricoma have been described in the literature, 15 of which were initially misdiagnosed and treated as onychomycosis. We present the case of a 66-year-old male with thickening and linear xanthonychia of the hallux nail plate secondary to an onychomatricoma misdiagnosed as onychomycosis. Read More

    The efficacy of fractional carbon dioxide (CO2) laser combined with terbinafine hydrochloride 1% cream for the treatment of onychomycosis.
    J Cosmet Laser Ther 2017 May 30:1-7. Epub 2017 May 30.
    a Department of Dermatology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
    Background: Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. Currently, laser treatment has been studied for its efficacy in the treatment of onychomycosis. Our study was aimed to evaluate the efficacy of fractional carbon dioxide (CO2) laser treatment combined with terbinafine cream for 6 months in the treatment of onychomycosis and to analyze the influencing factors. Read More

    The survey of tinea capitis and scalp dermatophyte carriage in nursing home residents.
    Med Mycol 2017 May 18. Epub 2017 May 18.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou and Taipei, Taiwan.
    Tinea capitis is a contagious dermatophyte infection of scalp and associated hairs. On the other hand, asymptomatic carriage is a status of positive dermatophyte scalp culture, but without signs or symptoms of tinea capitis, and no evidence of hair shaft invasion confirmed by direct microscopy. Tinea capitis and asymptomatic carriage mostly occur in children, but adult females are becoming another population in recent decades. Read More

    Evaluation of the efficacy and safety of tavaborole topical solution, 5%, in the treatment of onychomycosis of the toenail in adults: a pooled analysis of an 8-week, post-study follow-up from two randomized phase 3 studies.
    J Dermatolog Treat 2017 May 30:1-5. Epub 2017 May 30.
    f Oregon Dermatology and Research , Portland , OR , USA.
    Purpose: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis.

    Methods: We conducted a pooled analysis of 8-week, post-study follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail (CN) at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compared with placebo in adults with distal subungual onychomycosis was evaluated at week 60. Read More

    Usefulness of techniques based on real time PCR for the identification of onychomycosis-causing species.
    Mycoses 2017 May 16. Epub 2017 May 16.
    Mycology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
    Onychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT-PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Read More

    Performance of mycology and histopathology tests for the diagnosis of toenail onychomycosis due to filamentous fungi: Dermatophyte and non-dermatophyte moulds.
    Mycoses 2017 May 15. Epub 2017 May 15.
    Dermatology Departament, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. To evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. Patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. Read More

    Efinaconazole solution 10% for treatment of toenail onychomycosis in Latino patients.
    Cutis 2017 Apr;99(4):286-289
    Valeant Pharmaceuticals North America LLC, Bridgewater, New Jersey, USA.
    Onychomycosis is a common progressive fungal infection of the nail bed, matrix, or plate leading to destruction and deformity of the toenails and fingernails. The prevalence of onychomycosis is increasing in the United States, particularly in the growing population of Latino patients. In this study, we evaluated the efficacy and safety of efinaconazole solution 10% in Latino patients with onychomycosis. Read More

    Biosynthesis of zinc oxide nanoparticles by petals extract of Rosa indica L., its formulation as nail paint and evaluation of antifungal activity against fungi causing onychomycosis.
    IET Nanobiotechnol 2017 Mar;11(2):205-211
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.
    Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of Rosa indica L. (rose). Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. Read More

    Laser treatment of onychomycosis due to Neoscytalidium dimidiatum: An open prospective study.
    Med Mycol 2017 May 2. Epub 2017 May 2.
    Dermatology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Conventional systemic and topical treatments have proven ineffective for the treatment of onychomycosis caused by Neoscytalidium dimidiatum. Our aim was to evaluate the effectiveness and safety of laser monotherapy for the treatment of onychomycosis caused by this pathogen. Patients with clinical onychomycosis of the toenails and positive results both on direct mycological examination and N. Read More

    Caspofungin-Non-Susceptible Candida orthopsilosis Isolated from Onychomycosis in Iran.
    Iran J Public Health 2017 Feb;46(2):235-241
    Dept. of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species, there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied.

    Methods: We evaluated the in vitro antifungal susceptibilities of clinical isolates of C. Read More

    Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models.
    Antimicrob Agents Chemother 2017 Jul 27;61(7). Epub 2017 Jun 27.
    MedPharm Ltd., Surrey Research Park, Guildford, United Kingdom.
    In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models. Read More

    High prevalence of superficial white onychomycosis by Trichophyton interdigitale in a Japanese nursing home with a geriatric hospital.
    Mycoses 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, Kanazawa Medical University, Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, Japan.
    A mycological survey on feet was performed in a nursing home with a geriatric hospital to ascertain the prevalence of tinea lesions. Of 100 subjects, comprising 62 in the nursing home and 38 in the geriatric wing, 70 were diagnosed with tinea pedis, tinea unguium (onychomycosis) or both of which 54 had onychomycosis alone, nine tinea pedis alone and seven had co-existing onychomycosis and tinea pedis. The most common clinical type of onychomycosis was distal lateral subungual onychomycosis (DLSO) at 30 cases, followed by superficial white onychomycosis (SWO) at 23 cases. Read More

    An unusually large onychomatricoma.
    BMJ Case Rep 2017 Apr 21;2017. Epub 2017 Apr 21.
    Department of Dermatology, Hospital Garcia de Orta, Almada, Portugal.
    Onychomatricoma is a rare benign tumour of the nail matrix first described in 1992, and since then, no more than 80 cases have been reported. Despite distinct clinical characteristics, it is frequently misdiagnosed as onychomycosis partly due to remaining an unknown entity. The authors present the case of a patient with a 30-year history of nail abnormalities with more recent growth to alarming dimensions. Read More

    Dermatological comorbidity in psoriasis: results from a large-scale cohort of employees.
    Arch Dermatol Res 2017 Jul 12;309(5):349-356. Epub 2017 Apr 12.
    German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. Read More

    Examining the accuracy of visual diagnosis of tinea pedis and tinea unguium in aged care facilities.
    J Wound Care 2017 Apr;26(4):179-183
    Professor, Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Objective: The aim of this study was to examine the accuracy of visual diagnosis of tinea pedis (Athlete's foot) and tinea unguium (fungal nail infection), as well as to provide information on skin abnormalities that could help identify these diseases in aged care facilities (long-term care facilities (LTCFs) and nursing homes).

    Method: A multicentre, cross-sectional observational study was conducted in a LTCF and two nursing homes. A dermatologist observed the skin abnormalities in the participants' interdigital and plantar areas, to screen for tinea pedis, and in the participants' toenails, to screen for tinea unguium. Read More

    Clinical laser treatment of toenail onychomycoses.
    Lasers Med Sci 2017 Apr 4. Epub 2017 Apr 4.
    Department of Pathology and Experimental Therapeutics, Campus de Ciències de la Salut de Bellvitge, University of Barcelona, Barcelona, Spain.
    Onychomycoses are fungal infections of the fingernails or toenails having a prevalence of 3% among adults and accounts for 50% of nail infections. It is caused by dermatophytes, non-dermatophyte filamentous fungi, and yeasts. Compressions and microtraumas significantly contribute to onychomycosis. Read More

    [Mycological profile of onychomycosis in Yaoundé, Cameroon].
    J Mycol Med 2017 Jun 27;27(2):238-244. Epub 2017 Mar 27.
    Faculté de médecine et des sciences biomédicales (FMSB), B.P 8314, Yaoundé, Cameroun; Laboratoire de mycologie de la FMSB, Yaoundé, Cameroun.
    Background: The lack of data concerning the mycological spectrum of onychomycosis in Cameroon prompted us to conduct the present study, which aimed to determine the mycological profile of onychomycosis diagnosed during dermatologic consultations in Yaoundé, Cameroon.

    Methods: This was a cross-sectional study held from October 2014 to March 2015 in six hospitals of Yaoundé. Patients suspected of onychomycosis were consecutively recruited during dermatologic consultations; anamnestic and clinical data were recorded and one or several nail fragments sampled for mycological examination (direct examination or culture). Read More

    Stability of Two Antifungal Agents, Fluconazole and Miconazole, Compounded in HUMCO RECURA Topical Cream to Determine Beyond-Use Date.
    Int J Pharm Compd 2017 Mar-Apr;21(2):154-159
    HUMCO Research and Development Laboratory, Austin, Texas.
    A novel compounding vehicle (RECURA) has previously been proven to penetrate the nail bed when compounded with the antifungal agent miconazole or fluconazole, providing for an effective treatment for onychomycosis. In this study, miconazole and fluconazole were compounded separately in RECURA compounding cream, and they were tested at different time points (0, 7, 14, 28, 45, 60, 90, and 180 days) to determine the beyond-use date of those formulations. The beyond-use date testing of both formulations (10% miconazole in RECURA and 10% fluconazole in RECURA) proved them to be physically, chemically, and microbiologically stable under International Conference of Harmonisation controlled room temperature (25°C ± 2°C/60% RH ±5%) for at least 180 days from the date of compounding. Read More

    Efficacy and safety of luliconazole 5% nail solution for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.
    J Dermatol 2017 Jul 23;44(7):753-759. Epub 2017 Mar 23.
    Sato Pharmaceutical, Tokyo, Japan.
    Onychomycosis is a highly prevalent and intractable disease. The first-line treatment agents are oral preparations, but an effective topical medication has long been desired. The objective was to investigate the efficacy and safety of luliconazole 5% nail solution, an imidazole antifungal agent, for the treatment of patients with onychomycosis. Read More

    Photobiomodulation with non-thermal lasers: Mechanisms of action and therapeutic uses in dermatology and aesthetic medicine.
    J Cosmet Laser Ther 2017 Aug 17;19(4):190-198. Epub 2017 Feb 17.
    k Lorenc Aesthetic Plastic Surgery Center , New York , New York , USA.
    Background: Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light.

    Objectives: The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology.

    Methods: A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis. Read More

    A critical review of improvement rates for laser therapy used to treat toenail onychomycosis.
    J Eur Acad Dermatol Venereol 2017 Jul 3;31(7):1111-1118. Epub 2017 Apr 3.
    Mediprobe Research Inc., London, ON, Canada.
    Onychomycosis is a nail infection that is primary caused by dermatophytes. Alternative treatments are needed as current therapies (oral and topical antifungals) have limited effectiveness. Lasers are currently approved by the FDA to temporarily increase the amount of clear nail in onychomycosis patients. Read More

    Trans-ungual Delivery of AR-12, a Novel Antifungal Drug.
    AAPS PharmSciTech 2017 Mar 13. Epub 2017 Mar 13.
    The University of Mississippi, School of Pharmacy, University, Mississippi, USA.
    AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into and across the human nail plate followed by improving its trans-ungual permeation using different penetration enhancers. Read More

    Pathogenic Dermatophytes Survive in Nail Lesions During Oral Terbinafine Treatment for Tinea Unguium.
    Mycopathologia 2017 Aug 9;182(7-8):673-679. Epub 2017 Mar 9.
    Department of Dermatology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
    Tinea unguium caused by dermatophyte species are usually treated with oral antimycotic, terbinafine (TBF). To understand the mechanisms of improvement and recalcitrance of tinea unguium by oral TBF treatment, a method of quantifying dermatophyte viability in the nail was developed, and the viability of dermatophytes was analyzed in toenail lesions of 14 patients with KOH-positive tinea unguium treated with oral TBF 125 mg/day for up to 16 weeks. Mycological tests, including KOH examination and fungal culture, and targeted quantitative real-time PCR for internal transcribed spacer (ITS) region, including rRNA, were demonstrated at the initial visit and after 8 and 16 weeks of treatment. Read More

    The Effect of Long-Pulsed Nd:YAG Laser for the Treatment of Onychomycosis.
    J Am Podiatr Med Assoc 2017 Jan;107(1):54-59
    Background: Topical onychomycosis therapies are usually inadequate, and patient compliance to systemic therapies is poor. Recently, interest in laser therapy for the treatment of onychomycosis has increased. We sought to investigate the efficacy of long-pulsed Nd:YAG laser therapy for onychomycosis. Read More

    New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation.
    J Pharm Sci 2017 Jun 3;106(6):1570-1577. Epub 2017 Mar 3.
    Research Institute for Medicine and Pharmaceutical Science, Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. Electronic address:
    Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. Read More

    Nail neoplasms.
    J Dermatol 2017 Mar;44(3):279-287
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Nail neoplasms include all tumors occurring in the nail or periungual apparatus tissue. While some nail tumors can be similar to tumors located on the skin, others are unique. Both benign and malignant lesions can affect the nail apparatus. Read More

    In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis.
    Braz J Microbiol 2017 Jul - Sep;48(3):476-482. Epub 2017 Feb 9.
    Universidade Federal de Juiz de Fora, Faculdade de Farmácia, Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Juiz de Fora, MG, Brazil. Electronic address:
    Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. Read More

    Accelerated nail growth rate in HIV patients.
    Int J Dermatol 2017 May 23;56(5):524-526. Epub 2017 Feb 23.
    Dermatology Department, Mycology Section, General Hospital Dr. Manuel Gea González, Mexico City, Mexico.
    Background: Many factors have been noted to alter the growth rate of both finger and toe nails, some with harder evidence than others. Infectious diseases are among the ones reported as slowing the growth rate. However, on previous studies we noticed that patients living with HIV and onychomycosis could be cured without the use of antifungal therapy, only with the immunological improvement provided by the combined antiretroviral therapy, and we wanted to prove that the growth rate is also increased in this group and thus probably contributes to the cure of onychomycosis. Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Descriptive analysis of mycological examination of patients with onychomycosis treated in private practice.
    An Bras Dermatol 2017 Jan-Feb;92(1):134-136
    Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    This is a retrospective study of 160 patients treated in private practice in São Paulo from March 2003 to March 2015. We analyzed 171 results of direct mycological examinations and fungal cultures from nail scrapings. The agreement between direct mycological examination results and fungal culture was satisfactory, consistent with the literature (kappa 0. Read More

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