4,030 results match your criteria Onychomycosis


Occupational skin disorders in a subset of Nigerian hairdressers.

Pan Afr Med J 2018 10;31:100. Epub 2018 Oct 10.

Department of Medicine, University College Hospital Ibadan, Nigeria.

Introduction: Hairdressing is associated with a wide range of disorders. This is particularly true in the African hairdresser, who is saddled with the responsibility of 'taming' the rather difficult-to-manage African hair, and is thus exposed to a wide range of chemical, biological and physical materials in the hair grooming process. We therefore sought to determine the prevalence and pattern of occupational skin disorders among hairdressers in Ibadan, one of the oldest and largest cities in Nigeria. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.100.16499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461971PMC
October 2018

Green Nail Caused by Onychomycosis Coinfected With Pseudomonas aeruginosa.

Actas Dermosifiliogr 2019 Apr 20. Epub 2019 Apr 20.

Servicio de Microbiología, Universitario de Ferrol, Xerencia de Xestión Integrada de Ferrol, SERGAS, Ferrol, A Coruña, España.

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http://dx.doi.org/10.1016/j.ad.2018.04.013DOI Listing

The use of urea for the treatment of onychomycosis: a systematic review.

J Foot Ankle Res 2019 11;12:22. Epub 2019 Apr 11.

1Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, 5001 Australia.

Background: Onychomycosis, a fungal infection affecting the nail plate, is a common condition often requiring prolonged treatment regimens, with low success rates. Urea is one treatment option, which is thought to improve the efficacy of topical and oral antifungal agents. Despite a theoretical basis for the use of urea for the treatment of onychomycosis, the evidence-base for this treatment has not been systematically reviewed. Read More

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http://dx.doi.org/10.1186/s13047-019-0332-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458736PMC

Total Dystrophic Onychomycosis Due to - A Rare Cause and its Novel Treatment Option.

Indian Dermatol Online J 2019 Mar-Apr;10(2):171-173

Department of Skin and VD, SCB Medical College and Hospital, Cuttack, Odisha, India.

Onychomycosis is a fungal infection of the nail caused by dermatophytic (99%) and/or non-dermatophytic (1%) (including yeasts) infections of the nailplate. Among the non-dermatophytes, the yeast , , and other molds like spp., spp. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_155_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434749PMC
April 2019
2 Reads

Formulation evaluation of ketoconazole microemulsion-loaded hydrogel with nigella oil as a penetration enhancer.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmaceutics, Dr Bhanuben Nanavati College of Pharmacy, Mumbai, India.

Background: Onychomycosis is an opportunistic fungal infection often infecting people with compromised immune system. Currently available treatment interventions such as physical, surgical, and chemical-based approaches are successful in treating the condition, however, are painful and nonpatient complaint. Moreover, dermal creams with antifungal agents do not penetrate nail plate as required; hence, there is a necessity of developing a novel formulation with enhanced penetration. Read More

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http://dx.doi.org/10.1111/jocd.12945DOI Listing

Fungal Diversity and Onychomycosis .

J Am Podiatr Med Assoc 2019 Jan;109(1):57-63

Background: Onychomycosis is a fungal infection of the nail that is often recalcitrant to treatment and prone to relapse. Traditional potassium hydroxide and culture diagnosis is costly and time-consuming. Therefore, molecular methods were investigated to demonstrate effectiveness in diagnosis and to quantify the microbial flora present that may be contributing to disease. Read More

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http://dx.doi.org/10.7547/17-070DOI Listing
January 2019
1 Read

Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing.

Emerg Microbes Infect 2019 ;8(1):531-541

a Department of Microbiology, Li Ka Shing Faculty of Medicine , The University of Hong Kong , Pokfulam, Hong Kong.

Onychomycosis is most commonly caused by dermatophytes. In this study, we examined the spectrum of phenotypically non-dermatophyte and non-Aspergillus fungal isolates recovered over a 10-year period from nails of patients with onychomycosis in Hong Kong. A total of 24 non-duplicated isolates recovered from 24 patients were included. Read More

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http://dx.doi.org/10.1080/22221751.2019.1598781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455232PMC
January 2019
1 Read

Tinea manuum: a report of 18 cases observed in the metropolitan area of Milan and review of the literature.

Mycoses 2019 Mar 31. Epub 2019 Mar 31.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Objective: Tinea manuum is considered in Italy as an uncommon infection, although no recent epidemiological data are available.

Methods: In the period 2000-2018, we observed in the metropolitan area of Milan 18 patients with mycologically tinea manuum.

Results: The infection was monolateral in all patients and characterized by erythema and scaling; in two patients each vesicles and pustules were present. Read More

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http://dx.doi.org/10.1111/myc.12914DOI Listing
March 2019
2 Reads

Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride.

Materials (Basel) 2019 Mar 28;12(7). Epub 2019 Mar 28.

Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, 50161 Kaunas, Lithuania.

Topical monotherapy of nail infection is limited by poor drug permeability into the human nail plate. Numerous substances and methods are applied to improve the antifungal agent delivery across the nail plate. This work aimed to evaluate the effect of chemical and physical enhancers on the accumulation and permeation of amorolfine hydrochloride through human nail clippings. Read More

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http://dx.doi.org/10.3390/ma12071028DOI Listing

Laser therapy for onychomycosis in patients with diabetes at risk for foot ulcers: A randomised, quadruple-blind, sham controlled trial (LASER-1).

J Eur Acad Dermatol Venereol 2019 Mar 28. Epub 2019 Mar 28.

Medical Research Group Langerhans, Gerard Doustraat 36, 7731 MX, Ommen, the Netherlands.

Backgrounds: Patients with diabetes mellitus are at high risk for onychomycosis, which is related to development of foot ulcers.

Objective: The aim of this study was to evaluate the safety and efficacy of the treatment of onychomycosis with local laser therapy.

Methods: In a single-centre, randomised (1:1), quadruple blind, sham-controlled trial, patients with diabetes mellitus, at risk for developing diabetic foot ulcers (Sims classification score 1,2) and a clinical suspicion on onychomycosis were randomised to either 4 sessions neodymium- doped yttrium aluminium garnet (Nd-YAG) 1064nM laser or sham treatment. Read More

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http://dx.doi.org/10.1111/jdv.15601DOI Listing
March 2019
1 Read

Raman Microspectroscopy as a Tool to Elucidate the Efficacy of Topical Formulations Containing Curcumin.

Pharmaceuticals (Basel) 2019 Mar 23;12(1). Epub 2019 Mar 23.

São Carlos Institute of Physics, University of São Paulo, Trabalhador Sao-carlense Av., 400, São Carlos, SP 13566-590, Brazil.

The success of the onychomycosis treatment is directly associated with factors such as the choice of the medication, the administration route, and the pharmaceutical formulation. Photodynamic therapy (PDT) is an emerging and promising technique indicated for onychomycosis treatment. For this application, the main challenge is the efficient delivery of the photosensitizer (PS). Read More

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https://www.mdpi.com/1424-8247/12/1/44
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http://dx.doi.org/10.3390/ph12010044DOI Listing
March 2019
2 Reads

Improved Methods for Assessing Therapeutic Potential of Antifungal Agents Against Dermatophytes and their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.

Antimicrob Agents Chemother 2019 Mar 11. Epub 2019 Mar 11.

NovaBiotics Ltd, Cruickshank Building, Craibstone, Aberdeen, AB21 9TR, United Kingdom

Onychomycosis is a common, difficult to treat nail infection, mainly caused by dermatophytes. Current therapies are not wholly effective and are associated with manifold side effects. The development of treatments for onychomycosis is challenging because standard tests are not predictive of antifungal efficacy within the nail. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.02117-18
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http://dx.doi.org/10.1128/AAC.02117-18DOI Listing
March 2019
9 Reads

Onychomycosis of the Middle Finger of a Japanese Judo Athletedue to Trichophyton tonsurans.

Med Mycol J 2019 ;60(1):1-4

Medical Mycology Research Center, Chiba University.

We present a 17-year-old Japanese male high school student, who had applied steroid ointment for atopic dermatitis, with fingernail onychomycosis due to Trichophyton tonsurans. He was found positive for T. tonsurans infection based on hairbrush culture performed due to an epidemic of T. Read More

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http://dx.doi.org/10.3314/mmj.18-00012DOI Listing
January 2019
1 Read

Recent Findings in Onychomycosis and Their Application for Appropriate Treatment.

J Fungi (Basel) 2019 Feb 22;5(1). Epub 2019 Feb 22.

Galderma R&D, 06902 Sophia-Antipolis, France.

Onychomycosis is mainly caused by two dermatophyte species, and . A study of nail invasion mechanisms revealed that the secreted subtilisin Sub6, which has never been detected under in vitro growth conditions, was the main protease secreted by and during infection. In contrast, most of the proteases secreted during the digestion of keratin in vitro were not detected in infected nails. Read More

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http://dx.doi.org/10.3390/jof5010020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463057PMC
February 2019

Tavaborole 5% Topical Solution for the Treatment of Toenail Onychomycosis in Pediatric Patients: Results from a Phase 4 Open-Label Study

J Drugs Dermatol 2019 Feb;18(2):190-195

Background: This study was designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of tavaborole in pediatric patients. Study Design: In this open-label, single-arm study, pediatric patients (aged 6 to <17 years) with distal subungual onychomycosis affecting ≥20% of the target great toenail applied tavaborole once daily to all affected toenails (2 drops/great toenail, 1 drop/other toenail) for 48 weeks. In addition, a maximal-use subgroup (aged 12 to <17 years) applied tavaborole to all 10 toenails and ≤2 mm of surrounding skin for the first 28 days. Read More

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February 2019
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Epidemiology and Dermatological Comorbidity of Seborrhoeic Dermatitis - Population-based Study in 161,000 Employees.

Br J Dermatol 2019 Feb 25. Epub 2019 Feb 25.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Germany.

Background: Seborrhoeic dermatitis (SD) is a common but epidemiologically poorly researched chronic skin disease.

Objectives: To characterise the prevalence and dermatological comorbidity of SD in Germany.

Methods: In the course of voluntary company skin checks, full body examinations were carried out in more than 500 companies by experienced dermatologists and documented electronically. Read More

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http://dx.doi.org/10.1111/bjd.17826DOI Listing
February 2019
3 Reads

Culture-Proven Candida Albicans Endogenous Endophthalmitis in a Patient with Onychomycosis.

Ocul Immunol Inflamm 2019 Feb 22:1-4. Epub 2019 Feb 22.

a Department of Ophthalmology , Ankara University Faculty of Medicine , Ankara , Turkey.

Purpose: To report a case of Candida albicans endogenous endophthalmitis in an immunocompetent patient with onychomycosis.

Methods: Retrospective case report.

Results: A 40-year-old man with onychomycosis presented with C. Read More

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http://dx.doi.org/10.1080/09273948.2019.1568503DOI Listing
February 2019

Antifungal Susceptibility of Species Isolated from Horticulturists with Onychomycosis in Piauí, Brazil.

Iran J Public Health 2018 Dec;47(12):1816-1821

Nucleus Mycology, Adolfo Lutz Institute, São Paulo, Brazil.

Background: We aimed to assess susceptibility pattern of species isolated from horticulturists with onychomycosis to four antifungal drugs and to compare the effectiveness of conventional identification methods with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS).

Methods: This study was conducted in a community garden located in Teresina, State of Piauí, Brazil, in the year 2014. The samples were identified through phenotypic methods and per MALDI-TOF MS, being used PCR as definitive identification test. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379607PMC
December 2018
2 Reads
0.576 Impact Factor

New therapeutic options in the management of superficial fungal diseases.

Dermatol Ther 2019 Feb 12:e12855. Epub 2019 Feb 12.

Dermatology Department, Ataturk Training and Research Hospital, Ankara, Turkey.

Superficial fungal infections which effect the skin, hair, and nails, are widely observed in the world. Causative agents are Candida species, dermatophytes, and Malassezia species. In recent years, new antifungal agents and formulations have been developed for these infections. Read More

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http://dx.doi.org/10.1111/dth.12855DOI Listing
February 2019
1 Read

[Drug properties of fosravuconazole L-lysine ethanolate (NAILIN Capsules 100 mg), a new oral azole therapeutic for onychomycosis: an analysis based on non-clinical and clinical trial data].

Nihon Yakurigaku Zasshi 2019;153(2):79-87

Teikyo University Institute of Medical Mycology.

Ravuconazole is a fourth generation azole exerting strong antifungal activity, with low drug-drug interaction and hepatic dysfunction risks. Fosravuconazole l-lysine ethanolate (fosravuconazole; NAILIN Capsules 100 mg) was developed as a ravuconazole prodrug. Ravuconazole exerts strong antifungal activity against various pathogenic fungi including dermatophytes and Candida. Read More

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http://dx.doi.org/10.1254/fpj.153.79DOI Listing
January 2019
2 Reads

Demonstration of Adventitious Sporulation in Fusarium Petroliphilum Onychomycosis.

Mycopathologia 2019 Apr 8;184(2):303-308. Epub 2019 Feb 8.

Department of Microbiology, Faculty of Medicine, Kuwait University, P. O. Box 24923, 1311, Safat, Kuwait.

Fusarium petroliphilum is a recently described species within the Fusarium solani species complex. Some strains of Fusarium species are capable of forming yeast-like structures in tissue as well as in culture through a process known as "adventitious sporulation." Here, we describe the formation of these yeast-like reproductive structures in infected nail tissue obtained from a case of onychomycosis. Read More

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http://dx.doi.org/10.1007/s11046-019-0318-5DOI Listing
April 2019
2 Reads

Trends in Utilization and Expenditure for Onychomycosis Treatments in the United States in 2013-2016.

Am J Clin Dermatol 2019 Apr;20(2):311-313

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Suite 1600/Dermatology, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s40257-019-00425-xDOI Listing

Dermatophytosis caused by Nannizzia nana in two siblings.

Rev Iberoam Micol 2019 Jan - Mar;36(1):30-33. Epub 2019 Jan 25.

Dermatology Department and Mycology Section, "Dr. Eduardo Liceaga", General Hospital of Mexico, Mexico.

Background: Nannizzia nana is a zoophilic dermatophyte that affects animals like pigs, boars and, exceptionally, humans, in whom it causes tinea capitis, as well as tinea corporis and onychomycosis.

Case Report: Case 1. A previously healthy 8 year-old boy presented to our clinic with a 1-month evolution dermatosis that affected scalp, developing a pseudoalopecic tumor lesion with abundant seropurulent material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11301406193000
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http://dx.doi.org/10.1016/j.riam.2018.02.003DOI Listing
January 2019
11 Reads

Liquid chromatography-tandem mass spectrometry is effective for analysis of ergosterol in fungal-infected nails.

Authors:
W-T Ho Y Li S Yang

Clin Exp Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, China.

Background: Identification of onychomycosis is mainly based on clinical diagnosis with auxiliary diagnostic methods such as potassium hydroxide (KOH) microscopy, periodic acid-Schiff staining or fungal culture. However, each method is limited by its sensitivity and specificity.

Aim: To develop a new test method using the common fungal end product, ergosterol, and investigate if it can be used as a new diagnostic tool. Read More

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http://dx.doi.org/10.1111/ced.13933DOI Listing
January 2019
1 Read

Pharmacy Costs of Medications for the Treatment of Onychomycosis in the United States.

J Am Acad Dermatol 2019 Jan 25. Epub 2019 Jan 25.

Weill Cornell Medicine, Department of Dermatology, New York City, NY, USA.

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http://dx.doi.org/10.1016/j.jaad.2019.01.032DOI Listing
January 2019

Pharmacotherapy for onychomycosis: new and emerging treatments.

Authors:
Shari R Lipner

Expert Opin Pharmacother 2019 Apr 28;20(6):725-735. Epub 2019 Jan 28.

a Department of Dermatology , Weill Cornell Medicine , New York , NY , USA.

Introduction: Onychomycosis is the most common nail disorder seen in clinical practice. It is not merely an aesthetic disorder and may cause significant disability and affect the quality of life. There are no strict guidelines for onychomycosis therapy. Read More

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http://dx.doi.org/10.1080/14656566.2019.1571039DOI Listing
April 2019
6 Reads

Species distribution and epidemiological characteristics of superficial fungal infections in Southeastern Serbia.

Mycoses 2019 May 14;62(5):458-465. Epub 2019 Mar 14.

Department of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Superficial fungal infections (SFI), one of the most prevalent diseases in the world, are infections of keratin-rich structures of human body mostly caused by dermatophytes and yeasts.

Objectives: The goal of this study was to determine the possible changes in the epidemiology of SFI on the territory of Southeastern Serbia and to investigate epidemiological characteristics and the influence of SFI on the patient's quality of life.

Methods: From 2012 to the end of 2017, samples of 1643 patients (568 males and 1075 females, mean age 40. Read More

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http://dx.doi.org/10.1111/myc.12900DOI Listing

Topical ketoconazole: a systematic review of current dermatological applications and future developments.

J Dermatolog Treat 2019 Jan 22:1-12. Epub 2019 Jan 22.

a Department of Dermatology , University of California , Irvine , CA, USA.

Introduction: Although labeling changes and market withdrawal have been implemented for oral ketoconazole (KTZ) due to serious adverse effects (AEs), topical KTZ is generally thought to be effective and safe for the treatment of superficial fungal infections. New dermatologic indications for the use of topical KTZ have arisen such as onychomycosis, blepharitis, and hair loss. This article aims to review the literature on topical KTZ's efficacy and AEs, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573309DOI Listing
January 2019
3 Reads

Two Cases of Proximal Subungual Onychomycosis Caused by Trichophyton rubrum in HIV-negative Patients During Treatment with TNF-α Inhibitors Combined with Methotrexate.

Acta Dermatovenerol Croat 2018 Dec;26(4):304-306

Assist. Prof. Ditte Marie L. Saunte, MD, PhD, Department of Dermatology Zealand University Hospital; Roskilde, Sygehusvej 5, DK-4000 Roskilde, Denmark;

Proximal subungual onychomycosis (PSO) is a rare subtype of onychomycosis with a clinical presentation characterized by proximal leukonychia in the lunular area of the nail. PSO is associated with immunosuppression and regarded a sign of Human Immunodeficiency Virus (HIV) infection when caused by Trichophyton (T.) rubrum. Read More

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December 2018
3 Reads

Consumer Preferences of Antifungal Products for Treatment and Prevention of Tinea Pedis.

J Dermatolog Treat 2019 Jan 21:1-17. Epub 2019 Jan 21.

b Weill Cornell Medicine , Department of Dermatology , NY , NY.

Tinea pedis is a common condition seen in clinical practice and has a significant impact on quality of life. Recommendations of over-the-counter antifungal products based on consumer preferences may guide dermatologists in treating patients with tinea pedis and preventing onychomycosis recurrences. Our study aimed to determine consumer preferences of antifungal products for tinea pedis, focusing on features that may guide purchases and usage. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1572862DOI Listing
January 2019
13 Reads

Optimizing topical therapy for onychomycosis: the importance of patient education.

Cutis 2018 Dec;102(6):389-390

Duke University School of Medicine, Durham, North Carolina, USA.

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December 2018
8 Reads

Novel Point Mutations in cyp51A and cyp51B Genes Associated with Itraconazole and Posaconazole Resistance in Aspergillus clavatus Isolates.

Microb Drug Resist 2019 Jan 18. Epub 2019 Jan 18.

1 Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Aspergillus clavatus is a common environmental species known to cause occupational allergic disease in grain handlers. We have recently observed azole-resistant isolates of this fungus as a cause of onychomycosis. To further characterize the cause of resistance, the genes encoding 14 α-sterol demethylase enzyme (cyp51A and cyp51B) were characterized and analyzed in 9 ITC-susceptible isolates and 6 isolates with high minimum inhibitory concentrations (MICs) of clinical (nail and sputum) and environmental A. Read More

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https://www.liebertpub.com/doi/10.1089/mdr.2018.0300
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http://dx.doi.org/10.1089/mdr.2018.0300DOI Listing
January 2019
12 Reads
2.524 Impact Factor

Transungual Delivery of Ciclopirox Is Increased 3⁻4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model.

Pharmaceutics 2019 Jan 14;11(1). Epub 2019 Jan 14.

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. Read More

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http://dx.doi.org/10.3390/pharmaceutics11010029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358885PMC
January 2019
1 Read

Ciclopirox Hydroxypropyl Chitosan: Efficacy in Mild-to-Moderate Onychomycosis.

Skin Appendage Disord 2018 Nov 30;5(1):13-19. Epub 2018 May 30.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA.

The severity and percentage of nail involvement are usually considered the main prognostic factors for the treatment of onychomycosis. This study investigated the efficacy of P-3051 (ciclopirox [CPX] 8% nail lacquer in hydroxypropyl chitosan technology) in a population subset of the pivotal study, selected according to the criteria used in recent onychomycosis pivotal studies. The original study was a multicenter, randomized, three-arm, placebo-controlled, parallel groups, evaluator-blinded study comparing P-3051 with reference CPX (standard, insoluble 8% CPX nail lacquer) and placebo (P-3051 vehicle) in a 2: 2: 1 ratio, applied once daily for 48 weeks to 467 patients with onychomycosis, followed by a 12-week follow up. Read More

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https://www.karger.com/Article/FullText/488606
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http://dx.doi.org/10.1159/000488606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323372PMC
November 2018
6 Reads

Single-Center, Prospective, Blinded Study Comparing the Efficacy and Compatibility of Efinaconazole 10% Solution in Treating Onychomycosis with and without Concurrent Nail Polish Use.

Skin Appendage Disord 2018 Nov 25;5(1):9-12. Epub 2018 Apr 25.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Topical efinaconazole 10% solution is a promising new treatment for distal lateral subungual onychomycosis (DLSO). However, it is unknown whether this treatment is both compatible and efficacious in individuals wearing toenail polish.

Materials And Methods: We evaluated the efficacy and compatibility of efinaconazole 10% solution with concurrent nail polish use in treating DLSO over 52 weeks. Read More

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http://dx.doi.org/10.1159/000488369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323379PMC
November 2018
1 Read

Factors associated with onychomycosis in nail psoriasis: a multicenter study in Pakistan.

Int J Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Dermatology Department, Abbassi Shaheed Hospital, Karachi, Pakistan.

Background: Treatment of psoriatic nail disease is challenging, and dystrophic psoriatic nails can get secondarily infected with fungi.

Methods: This 2-year, matched case-control study was conducted at three tertiary care centers of Karachi, Pakistan. Data were collected from patients with nail psoriasis as cases with age- and gender-matched controls. Read More

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http://doi.wiley.com/10.1111/ijd.14364
Publisher Site
http://dx.doi.org/10.1111/ijd.14364DOI Listing
January 2019
13 Reads
1.227 Impact Factor

Antimicrobial photodynamic therapy with phenothiazinium photosensitizers in non-vertebrate model Galleria mellonella infected with Fusarium keratoplasticum and Fusarium moniliforme.

Photodiagnosis Photodyn Ther 2019 Mar 23;25:197-203. Epub 2018 Dec 23.

Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040-903, Brazil. Electronic address:

Fusarium keratoplasticum and Fusarium moniliforme are filamentous fungi common in the environment and cause mycosis in both animals and plants. Human infections include mycetoma, keratitis and onychomycosis, while deeper mycosis occurs in immunocompromised patients. Most of the Fusarium spp. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183035
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http://dx.doi.org/10.1016/j.pdpdt.2018.12.010DOI Listing
March 2019
13 Reads

Global perspectives for the management of onychomycosis.

Int J Dermatol 2018 Dec 25. Epub 2018 Dec 25.

Fredric Brandt Endowed Professor of Dermatology, University of Miami, Miami, FL, USA.

Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophyte molds, and yeasts. This difficult-to-treat chronic infection has a tendency to relapse despite treatment. This paper aims to offer a global perspective on onychomycosis management from expert physicians from around the world. Read More

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http://dx.doi.org/10.1111/ijd.14346DOI Listing
December 2018
7 Reads

Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients.

Int J Dermatol 2019 Apr 22;58(4):440-448. Epub 2018 Nov 22.

Department of Dermatology, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Sao Paulo, Brazil.

Background: Skin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in.

Methods: 177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases. Read More

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http://dx.doi.org/10.1111/ijd.14285DOI Listing
April 2019
5 Reads

Author's reply.

Authors:
Sanjay Singh

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):84-85

Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_927_18DOI Listing

Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining.

Sci Rep 2018 Dec 14;8(1):17840. Epub 2018 Dec 14.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rules in multiple sequential data sets. Read More

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http://dx.doi.org/10.1038/s41598-018-35909-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294792PMC
December 2018
3 Reads

Polyurethanes as New Excipients in Nail Therapeutics.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Research Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal.

Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321266PMC
December 2018
1 Read

Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.

Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321522PMC
December 2018
14 Reads

Toenail alterations in chronic venous disease patients are not always of mycotic origin.

Phlebology 2018 Dec 12:268355518818619. Epub 2018 Dec 12.

1 Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Objective: The prevalence of toenail alterations in chronic venous disease has only rarely been studied. We aimed to establish the frequency and clinical characteristics of toenail onychomycosis in chronic venous disease.

Methods: We included 80 adult patients, in all stages of chronic venous disease. Read More

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http://dx.doi.org/10.1177/0268355518818619DOI Listing
December 2018
2 Reads

Allergic contact dermatitis caused by undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2019 May 16;80(5):313-314. Epub 2019 Jan 16.

Department of Dermatology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

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http://dx.doi.org/10.1111/cod.13195DOI Listing
May 2019
10 Reads

Fusarium oxysporum is an onychomycosis etiopathogenic agent.

Future Microbiol 2018 12 3;13:1745-1756. Epub 2018 Dec 3.

Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá (UEM), Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil.

Aim: To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source.

Materials & Methods: The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscopy (SEM), CFU, matrix, histopathology and Fourier Transform Infrared Spectrometer coupled to an equipment with diamond accessory (FTIR-ATR).

Results: F. Read More

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http://dx.doi.org/10.2217/fmb-2018-0245DOI Listing
December 2018
3 Reads

Propolis for the Treatment of Onychomycosis.

Indian J Dermatol 2018 Nov-Dec;63(6):515-517

Department of Clinical Analysis and Biomedicine, State University of Maringá, Paraná, Brazil.

Onychomycosis is a fungal nail infection, considered as a public health problem because it is contagious and it interferes with the quality of life. It has long and difficult treatment, with many side effects and high cost. Propolis extract (PE) is a potential alternative to conventional antifungal agents because it has low cost, accessibility, and low toxicity. Read More

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http://dx.doi.org/10.4103/ijd.IJD_365_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233048PMC
December 2018
2 Reads

Frequency of Fungal Species of Onychomycosis between Diabetic and Non-Diabetic Patients.

Mymensingh Med J 2018 Oct;27(4):752-756

Dr Sharmin Sultana, Medical Officer, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Onychomycosis is a common nail problem in our country. Diabetic patients are more prone to develop onychomycosis. Various types of fungi are the causative agents of nail infections. Read More

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October 2018
1 Read

Analysis of the role of nail polish in the transmission of onychomycosis.

An Bras Dermatol 2018 Nov/Dec;93(6):930-931

Interdisciplinary Field of Biomedical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande (RS), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20187791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256209PMC
February 2019
2 Reads

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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http://dx.doi.org/10.5826/dpc.0804a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246064PMC
October 2018
4 Reads