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    1 OF 76

    SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis.
    Curr Pharm Des 2017 Nov 14. Epub 2017 Nov 14.
    Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goias, Rua 240, esq. com 5ª Avenida, Setor Leste Universitario, 74605-170, Goiania, GO. Brazil.
    Background: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. Read More

    Optimized Ciclopirox-Based Eudragit RLPO Nail Lacquer: Effect of Endopeptidase Enzyme as Permeation Enhancer on Transungual Drug Delivery and Efficiency Against Onychomycosis.
    AAPS PharmSciTech 2017 Nov 14. Epub 2017 Nov 14.
    Pharmaceutic Department, National Organization for Drug Control and Research, Giza, Egypt.
    The aims of our investigation were to develop and optimize ciclopirox (CPX) nail lacquer using nonbiodegradable Eudragit RLPO (E-RLPO) as a film former and to assess its penetration efficiency across the human nail plate. Preliminary trials such as hydration enhancement factor (HEF), a retained drug in the nail plate, and SEM were studied to select the optimized permeation enhancer to be incorporated in the optimized lacquer formulation. A 3(3) full factorial design was built up to study the effect of three different factors, concentration of E-RLPO (10, 20, and 30%), Tween 80 (0. Read More

    Clinical trial designs for topical antifungal treatments of onychomycosis and implications on clinical practice.
    Cutis 2017 Oct;100(4):259-264
    Pinehurst Skin Center, North Carolina, USA.
    There currently are 3 topical agents approved by the US Food and Drug Administration (FDA) to treat onychomycosis: tavaborole, efinaconazole, and ciclopirox. The phase 3 clinical trial designs for these treatments and their notable differences make it difficult for clinicians to interpret the data into clinical practice. For example, the primary end point predominantly used to assess efficacy in all the trials is complete cure, defined as no involvement of the nail plus mycologic cure; also, a notable number of patients fail to achieve a complete cure despite clear improvement in the nail. Read More

    ENHANCEMENT OF TIOCONAZOLE UNGUAL DELIVERY: COMBINING NANOCAPSULE FORMULATION AND NAIL PORATION APPROACHES.
    Int J Pharm 2017 Nov 7. Epub 2017 Nov 7.
    Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom. Electronic address:
    This work investigated the impact of formulation including in vitro release profile, repeated dosing, and nail poration on the ex vivo nail delivery performance of antifungal formulations. Chitosan coated and uncoated tioconazole-loaded nanocapsules and a nano-based film-forming vehicle were assessed via in vitro release and in vitro permeation tests using an artificial membrane and human nail clippings, respectively. The later involved single and daily dosing experiments with intact and porated nails. Read More

    [Clinical and mycological characteristics of onychomycosis due to Candida at Institut Pasteur of Côte d'Ivoire].
    J Mycol Med 2017 Nov 7. Epub 2017 Nov 7.
    Unité de mycologie, institut Pasteur, 01 BP 490, Abidjan, Côte d'Ivoire.
    Objective: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire.

    Patients And Methods: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded.

    Results: In this study, 1898 patient files were selected. Read More

    Risk of Psoriasis Following Terbinafine or Itraconazole Treatment for Onychomycosis: A Population-Based Case-Control Comparative Study.
    Drug Saf 2017 Nov 6. Epub 2017 Nov 6.
    Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan.
    Introduction: Several case studies have reported an association between antifungal drug use and psoriasis risk.

    Objective: The objective of this study was to investigate the association between terbinafine/itraconazole exposure and psoriasis incidence.

    Methods: Among patients with onychomycosis in the Taiwan National Health Insurance Research Database, 3831 incident psoriasis cases were identified during 2004-2010 and compared with 3831 age- and sex-matched controls with the same look-back period. Read More

    In vitro human onychopharmacokinetic and pharmacodynamic analyses of ME1111, a new topical agent for onychomycosis.
    Antimicrob Agents Chemother 2017 Oct 30. Epub 2017 Oct 30.
    University of California, San Francisco, United States.
    ME1111 is a novel antifungal agent currently under clinical development as a topical onychomycosis treatment. A major challenge in application of topical onychomycotics is penetration and dissemination of antifungal agent into the infected nail plate and bed. In this study, pharmacokinetic/pharmacodynamic parameters of ME1111 that potentially correlate with clinical efficacy were compared with those of marketed topical onychomycosis antifungal agents: efinaconazole, tavaborole, ciclopirox, and amorolfine. Read More

    Clinico-aetiologic profile of Onychomycoses in a tertiary care centre in northeast India.
    Trop Doct 2017 Jan 1:49475517735979. Epub 2017 Jan 1.
    5 Senior Resident (Microbiology), 56918 NEIGRIHMS , Shillong, India.
    Onychomycosis refers to fungal nail infection. Despite a clearly diseased appearance, it is often deemed a merely cosmetic problem of relatively minor importance. However, it may result in much psychological or occupational turmoil, diminished self-esteem and resulting reluctance for public interaction. Read More

    Point-of-Care Diagnosis of Onychomycosis by Dermoscopy.
    J Am Podiatr Med Assoc 2017 Sep;107(5):413-418
    Background: Onychomycosis is one of the most common diseases of the toenails. The costs of diagnosis and treatment are substantial, and as the population ages, the overall cost burden will continue to escalate. The purpose of this study was to correlate dermoscopic features with pathologic diagnosis to support the accuracy of point-of-care diagnosis by dermoscopic examination. Read More

    Precise laser poration to control drug delivery into and through human nail.
    J Control Release 2017 Oct 16;268:72-77. Epub 2017 Oct 16.
    Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK; Centre for Nanoscience & Nanotechnology, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address:
    Drug treatment of diseases of the human nail remains a difficult challenge; topical therapy, in particular, is limited by very poor transport of active agents across the nail itself. The objective of this research was to examine the potential of controlled, and fibre-optic delivered, femtosecond laser light pulses to provide new pathways and opportunities for drug access to targets within and beneath the nail plate. Optical, confocal fluorescence and scanning electron microscopies demonstrated partial and complete laser poration of human nail samples, with the energy per pore and the exposure duration being the key modulating parameters that determined the extent of ablation achieved. Read More

    Management of mycoses in daily practice.
    G Ital Dermatol Venereol 2017 Dec;152(6):642-650
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, IRCCS Foundation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy -
    The guideline recommendations, albeit founded on thorough reviews of clinically relevant literature data, are often not immediately adaptable to everyday life. Considering the marked heterogeneity of superficial mycoses, each of them requires specific management in a real life context; in all cases diagnostic confirmation is required with microscopic and culture examination. In tinea capitis oral therapy is necessary (minimum six weeks) and should be continued until clinical and, above all, mycological healing. Read More

    Tavaborole in Difficult-to-Treat Onychomycosis Cases: A Post-hoc Assessment of Phase III Subjects.
    J Drugs Dermatol 2017 Oct;16(10):1016-1021
    Toenail onychomycosis is a chronic fungal infection that often requires prolonged treatment in order to effectively manage pathogenic organisms and obtain a clear nail. Traditionally, certain clinical features of onychomycosis, including the presence of substantial lateral disease, focal fungal masses, yellow/brown streaks, and extensive nail involvement (ie, >50%), indicate a poor treatment prognosis and have proven difficult-to-treat with oral or traditional topical therapies. Owing to the novel features of topical tavaborole, we sought to understand the potential utility of tavaborole in difficult-to-treat onychomycosis. Read More

    Treatment of Dermatophytosis in Elderly, Children, and Pregnant Women.
    Indian Dermatol Online J 2017 Sep-Oct;8(5):310-318
    Department of Dermatology, Venereology and Leprology, PGIMER, Chandigarh, India.
    Dermatophytic infection of the skin and its appendages is a common occurrence. Though usually straightforward, treatment of dermatophytosis becomes notably challenging in certain population groups - pregnant women, children, and elderly. Treatment with topical azoles/allylamines alone is effective in limited cutaneous disease in all three groups. Read More

    1340nm LASER THERAPY FOR ONYCHOMYCOSIS: Negative Results of Prospective Treatment of 72 Toenails and a Literature Review.
    J Clin Aesthet Dermatol 2017 Aug 1;10(8):56-61. Epub 2017 Aug 1.
    Drs. Espírito-Santo, Leite, Hoffmann-Santos, Dias, and Hahn are with the Faculty of Medicine, Post Graduate in Health Sciences at the Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil.
    Onychomycosis is an infection of the nail plate by fungal microorganisms. This infection has an important social impact on women and men and poses a major challenge for its treatment. The traditional treatment of onychomycosis involves the use of topical and oral antifungal agents. Read More

    Antibiofilm activity of propolis extract on Fusarium species from onychomycosis.
    Future Microbiol 2017 Nov 4;12:1311-1321. Epub 2017 Oct 4.
    Laboratory of Medical Mycology, Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá (UEM), Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil.
    Aim: The present study evaluated the capacity of three species of Fusarium isolated from onychomycosis to form biofilms and the antibiofilm effect of propolis extract on these biofilms.

    Materials & Methods: The biofilms and antibiofilm effects were evaluated by quantifying the colony-forming units, mitochondrial metabolic activity assays, total biomass by crystal violet staining and scanning electron microscopy.

    Results: Propolis extract demonstrated significant antibiofilm efficiency on Fusarium spp. Read More

    Draft Genome Sequences of Trichophyton rubrum CMCC(F)T1i and Trichophyton violaceum CMCC(F)T3l by Illumina 2000 and Pacific Biosciences.
    Genome Announc 2017 Sep 28;5(39). Epub 2017 Sep 28.
    Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China
    One strain of Trichophyton rubrum CMCC(F)T1i (=CBS 139224) isolated from onychomycosis and one strain of Trichophyton violaceum CMCC(F)T3l (=CBS 141829) isolated from tinea capitis in China were whole-genome sequenced by Illumina/Solexa, while the former was also sequenced by Pacific Biosciences sequencing in parallel. Read More

    Confirmatory Testing Prior to Initiating Onychomycosis Therapy Is Cost-Effective.
    J Cutan Med Surg 2017 Sep 1:1203475417733461. Epub 2017 Sep 1.
    3 Department of Medicine (Dermatology, Clinical Pharmacology and Toxicology) and Department of Pharmacology, Sunnybrook and Women's College Health Science Centre and the University of Toronto, Toronto, ON, Canada.
    Background: Onychomycosis can be investigated by sampling. Information gleaned includes nail bed involvement, nail plate penetration, fungal viability, and species identification. Testing samples can confirm a diagnosis. Read More

    In vitro biofilms and antifungal susceptibility of dermatophyte and non-dermatophyte moulds involved in foot mycosis.
    Mycoses 2017 Sep 22. Epub 2017 Sep 22.
    Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
    Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non-dermatophyte moulds are aetiological agents of foot mycosis and are capable of forming biofilms. Fungal biofilm has demonstrated increasing drug resistance. Read More

    Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis.
    Mycoses 2017 Sep 19. Epub 2017 Sep 19.
    Galderma International, Paris, France.
    Patient adherence is a key consideration in the choice of a topical regimen for the treatment of onychomycosis. The objective of this study was to investigate patient-reported outcomes (treatment utilisation, adherence and satisfaction) in onychomycosis treated with once-weekly amorolfine 5% nail lacquer versus once-daily ciclopirox 8% nail lacquer (Study A) or once-daily urea 40% ointment/bifonazole 1% cream combination regimen (Study B). Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks. Read More

    A pilot single centre, double blind, placebo controlled, randomized, parallel study of Calmagen® dermaceutical cream and lotion for the topical treatment of tinea and onychomycosis.
    BMC Complement Altern Med 2017 Sep 18;17(1):464. Epub 2017 Sep 18.
    Xerion Limited, Brighton, Victoria, 3186, Australia.
    Background: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis).

    Methods: A randomized, placebo-controlled, double blind, parallel, single centre study was conducted on 28 subjects with severe to very severe tinea or onychomycosis. Read More

    New insight into the pathogenesis of nail psoriasis and overview of treatment strategies.
    Drug Des Devel Ther 2017 30;11:2527-2535. Epub 2017 Aug 30.
    Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
    Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Read More

    New formulation for topical treatment of onychomycoses.
    G Ital Dermatol Venereol 2017 Oct;152(5):432-435
    Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
    Background: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient. Read More

    The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Medical Research Center, PEDEGO Research Group, University of Oulu and Oulu University Hospital, FIN-90029 OYS Oulu, Finland.
    Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. Read More

    Reversible naftifine-induced carotenoid depigmentation in Rhodotorula mucilaginosa (A. Jörg.) F.C. Harrison causing onychomycosis.
    Sci Rep 2017 Sep 11;7(1):11125. Epub 2017 Sep 11.
    Babeș-Bolyai University, Faculty of Biology and Geology, 42 Republicii Street, 400015, Cluj-Napoca, Romania.
    Rhodotorula mucilaginosa was isolated from a patient with onychomycosis, and identification was confirmed by morphological and cultural characteristics as well as by DNA molecular analysis. Antifungal agents naftifine (10 mg/mL, active substance in Exoderil) and bifonazole (10 mg/mL, active substance in Canespor) were tested in different concentrations to assess in vitro effects on fungal growth and carotenoid synthesis. The antifungal mechanisms of action of naftifine and bifonazole against R. Read More

    [Mycological profile of hand onychomycosis amongs "Garba" sellers in Abidjan (Côte d'Ivoire)].
    J Mycol Med 2017 Sep 5. Epub 2017 Sep 5.
    Laboratoire de parasitologie-mycologie-zoologie,unité de formation et de recherche des sciences pharmaceutiques et biologiques, université Félix-Houphouet-Boigny, BPV 34 Abidjan, Cote d'Ivoire; Laboratoire de parasitologie-mycologie, centre de diagnostic et de recherche sur le Sida et les autres maladies infectieuses, CHU de Treichville, 01 BPV 3 Abidjan, Cote d'Ivoire.
    Objective: The aim of this study is to determine the prevalence and the fungi involved in onychomycosis located on fingers in Abidjan.

    Material And Methods: This study includes the sellers of cooked cassava semolina served with fried tuna fish called "garba". Fines squames specimen was processed with 30% KOH for a direct microscope examination. Read More

    Onychomycosis InfectionsDo Polymerase Chain Reaction and Culture Reports Agree?
    J Am Podiatr Med Assoc 2017 Jul;107(4):280-286
    Background: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections.

    Methods: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs. Read More

    Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness.
    Skin Appendage Disord 2017 Aug 21;3(3):144-155. Epub 2017 Apr 21.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
    Purpose: Onychomycosis is the most common nail disorder and causes morbidity and impaired quality of life (QOL). Patient-reported outcomes (PRO) are patients' assessment of their health status or treatment response. PROs help assess what is most bothersome to patients to identify targets for intervention. Read More

    Prevalence of onychomycosis among patients with nail psoriasis who are not receiving immunosuppressive agents: Results of a pilot study.
    Mycoses 2017 Sep 6. Epub 2017 Sep 6.
    2nd Department of Dermatology, Faculty of Medicine, Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
    Nail psoriasis and onychomycosis can often be hard to differentiate clinically and may coexist, complicating each other's course. The aim of this study was to determine the prevalence of onychomycosis among patients with nail psoriasis not being treated with immunosuppressive agents, which constitute an independent risk factor for fungal infections. A cross-sectional study was performed. Read More

    Voriconazole-loaded nanostructured lipid carriers (NLC) for drug delivery in deeper regions of the nail plate.
    Int J Pharm 2017 Oct 30;531(1):292-298. Epub 2017 Aug 30.
    Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, 74.605-170, Goiânia, GO, Brazil. Electronic address:
    Voriconazole-loaded nanostructured lipid carriers (VOR-NLC) were developed and drug penetration evaluated in porcine hooves in vitro. Synergistic effect of urea (Ur), selected among other known chemical enhancers according to hoof hydration potential, was also evaluated. VOR-NLC presented a high encapsulation efficiency (74. Read More

    Topical antifungal treatment prevents recurrence of toenail onychomycosis following cure.
    Dermatol Ther 2017 Sep 30;30(5). Epub 2017 Aug 30.
    Mediprobe Research, Inc., London, Ontario, Canada.
    Recurrence rates are high for onychomycosis, with prophylactic topical antifungal use proposed to counter recurrence. Although this is a reasonable action for many clinicians, few studies have been conducted on the efficacy of topical prophylaxis. A retrospective chart review (2010-2015) was conducted in patients receiving oral terbinafine or itraconazole for toenail onychomycosis. Read More

    Human Infections with Microsporum gypseum Complex (Nannizzia gypsea) in Slovenia.
    Mycopathologia 2017 Dec 24;182(11-12):1069-1075. Epub 2017 Aug 24.
    University Medical Centre Ljubljana, Ljubljana, Slovenia.
    Microsporum gypseum complex is a group of geophillic dermatophytes with a worldwide distribution and is a rare cause of dermatomycoses in humans. The infection most commonly presents as tinea corporis, with some geographical and occupational variations. We studied M. Read More

    Case Report of Onychomycosis and Tinea Corporis Due to Microsporum gypseum.
    J Cutan Med Surg 2017 Aug 1:1203475417724439. Epub 2017 Aug 1.
    2 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Background: Microsporum gypseum is a geophilic dermatophyte that colonises keratinous substances in the soil. Fur-bearing animals carry this dermatophyte but are rarely infected. Human infection can be acquired from the soil, carrier or infected animals, and rarely other humans. Read More

    Utility of Boron in Dermatology.
    J Dermatolog Treat 2017 Aug 9:1-20. Epub 2017 Aug 9.
    a Department of Dermatology , Center for Dermatology Research, Wake Forest School of Medicine , Winston-Salem , North Carolina.
    Introduction: Boron compounds are being investigated as therapies for dermatologic conditions. Several features of boron chemistry make this element an ideal component in dermatologic treatments. We review the published dermatologically-relevant clinical trials and case studies pertaining to boron compounds. Read More

    Early Visible Improvements during K101-03 Treatment: An Open-Label Multicenter Clinical Investigation in Patients with Onychomycosis and/or Nail Psoriasis.
    Dermatology 2017 5;233(2-3):178-183. Epub 2017 Aug 5.
    Department of Experimental, Diagnostic and Specialty Medicine, Università di Bologna, Bologna, Italy.
    Introduction: Onychomycosis and nail psoriasis can be embarrassing to patients, so improving the appearance of affected nails should be one of the key short-term goals of treatment.

    Methods: An 8-week open-label multicenter study was conducted to assess whether K101-03, a marketed topical treatment containing propylene glycol, glycerol, urea, and lactic acid, could produce rapid cosmetic improvements in affected nails. Adult patients with a big toenail or thumbnail (the "target" nail) affected by onychomycosis (n = 72) or psoriasis (n = 34) or both (n = 1) applied K101-03 to their affected nails once a day for 8 weeks. Read More

    Subungual Squamous Cell Carcinoma Associated with Long Standing Onychomycosis: Aggressive Surgical Approach with a Favourable Outcome.
    Open Access Maced J Med Sci 2017 Jul 21;5(4):480-482. Epub 2017 Jul 21.
    Department of Dermatology and Allergology at the Academic Teaching Hospital Dresden-Friedrichstadt in Dresden, Germany.
    Background: Tumours of the nail bed are rare. Squamous cell carcinoma is the most frequent among them. Chronic infection, chemical or physical trauma/microtrauma, genetic disorders such as congenital ectodermal dysplasia, radiation, tar, arsenic or exposure to minerals, sun exposure, immunosuppression, and previous HPV infection have all been discussed as etiologic factors. Read More

    Epidemiology of dermatomycoses in Kerman province, southeast of Iran: A 10-years retrospective study (2004-2014).
    Microb Pathog 2017 Sep 27;110:561-567. Epub 2017 Jul 27.
    School of Medicine, Bam University of Medical Sciences, Bam, Iran.
    Objectives: Superficial and cutaneous fungal infections (SCFIs) are an important public health problem and are common in tropical and subtropical countries. Pityriasis versicolor, dermatophytosis, erythrasma, onychomycosis, and otomycosis are the major diseases associated with SCFIs. The aim of this study was to evaluate the prevalence and causative agents of dermatomycoses over a period of 10 years in Kerman province, southeast of Iran. Read More

    The increasing relevance of biofilms in common dermatological conditions.
    J Dermatolog Treat 2017 Aug 9:1-6. Epub 2017 Aug 9.
    b Department of Dermatologic Surgery and Laser Unit, St. Thomas' Hospital , St. John's Institute of Dermatology , London , UK.
    Background: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavorable conditions and antibiotics.

    Methods: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. Read More

    Highlights of Skin Disease Education Foundation's 41st Annual Hawaii Dermatology Seminar™.
    Semin Cutan Med Surg 2017 Jun;36(3S):S52-S59
    Clinical Instructor, Department of Dermatology, The University of British Columbia, Vancouver, British Columbia, Canada.
    New therapies, recent pathophysiological findings, and updated guidelines combined to create compelling presentations at the Skin Disease Education Foundation's 41st Annual Hawaii Dermatology Seminar™. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. A growing understanding of the biology of psoriasis has facilitated the development of increasingly efficacious medications. Read More

    Mycology of Onychomycosis: A 5-year retrospective review (2011 - 2015) in Hospital Kuala Lumpur.
    Med J Malaysia 2017 Jun;72(3):190-192
    Hospital Kuala Lumpur, Department of Dermatology, Malaysia.
    Onychomycosis is a common nail disease with numerous etiological pathogens. In order to determine and trend the local mycological pattern of culture-positive diseased nail samples sent from the Department of Dermatology, Hospital Kuala Lumpur, a five-year retrospective audit was carried out, which revealed that non-dermatophyte molds were the predominant fungi isolated, followed by yeasts and dermatophytes. This is similar to two previous studies in Malaysia, but varies greatly from other studies around the world which showed a dermatophyte-predominant prevalence. Read More

    [Algorithm to facilitate the management of onychomycosis].
    Rev Med Suisse 2017 Mar;13(556):698-702
    Service de dermatologie et vénéréologie, CHUV, 1011 Lausanne.
    An algorithm is proposed to facilitate the management of onychomycosis and ensure a good therapeutical approach. Its aim is to simplify the diagnosis process by integrating a pertinent anamnesis and physical examination with the classic tool of mycology (direct examination, culture, eventually examination by PCR), in order to give the adequate targeted treatment. Read More

    Oral antifungal medication for toenail onychomycosis.
    Cochrane Database Syst Rev 2017 07 14;7:CD010031. Epub 2017 Jul 14.
    Primary Care Clinical Unit, Faculty of Medicine, The University of Queensland, Level 8, Health Sciences Building 16/910, Royal Brisbane & Women's Hospital Complex, Brisbane, Herston, Queensland, Australia, 4029.
    Background: Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or applied topically; however, traditionally topical treatments have low success rates due to the nail's physical properties. Read More

    Current mycological profile of onychomycosis in Kashmir valley: A hospital-based study.
    J Lab Physicians 2017 Jul-Sep;9(3):190-194
    Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, India.
    Introduction: Onychomycosis is a common nail ailment associated with significant physical and psychological morbidity. It is caused by dermatophytes, nondermatophytic molds, and yeasts. Increased prevalence in the recent years is attributed to enhanced longevity, comorbid conditions such as diabetes, avid sports participation, and emergence of HIV. Read More

    Current antifungal treatment of fusariosis.
    Int J Antimicrob Agents 2017 Jul 10. Epub 2017 Jul 10.
    Centre of Expertise in Mycology Radboudumc/ Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
    Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and it is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Read More

    Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach.
    AAPS PharmSciTech 2017 Jul 5. Epub 2017 Jul 5.
    Drug Discovery Lab, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Opp. To Air force Station, Palaj, Gandhinagar, Gujarat, 382355, India.
    The present investigation focused on developing, optimizing, and evaluating a novel liposome-loaded nail lacquer formulation for increasing the transungual permeation flux of terbinafine HCl for efficient treatment of onychomycosis. A three-factor, three-level, Box-Behnken design was employed for optimizing process and formulation parameters of liposomal formulation. Liposomes were formulated by thin film hydration technique followed by sonication. Read More

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