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    Risk Factors and Frequency of Ingrown Nails in Adult Diabetic Patients.
    J Foot Ankle Surg 2018 Jan 10. Epub 2018 Jan 10.
    Professor, Department of Neurology, Faculty of Medicine, Ankara University, Ankara, Turkey.
    The present study evaluated the properties of nails, frequency of ingrown nails in patients with type 2 diabetes mellitus (DM), risk factors for developing ingrown nails, and effect of diabetic polyneuropathy and vasculopathy on the development and outcome of ingrown nails. Our 6-month epidemiologic prospective study included 300 patients with type 2 DM attending a DM outpatient clinic for routine examinations. The general characteristics and foot changes of the study population were investigated. Read More

    Terbinafine hydrochloride nail lacquer for the management of onychomycosis: formulation, characterization and in vitro evaluation.
    Ther Deliv 2018 Feb;9(2):99-119
    Department of Pharmaceutical Sciences, Pharmaceutics Division, Punjabi University, Patiala, 147002, India.
    Aim: The present investigation's intention was to develop an optimized nail lacquer (NL) for the management of onychomycosis.

    Materials & Methods: The NL was optimized statistically adopting 32 full factorial design having different polymer ratios and solvent ratios. The formulations were assessed for drug permeation drying time and peak adhesive strength of the film. Read More

    Nail changes in alopecia areata: an update and review.
    Int J Dermatol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
    Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer-reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms "nail changes alopecia areata," "alopecia areata nails," and specific searches on "trachyonychia alopecia areata" and "pitting alopecia areata. Read More

    Clinical features and nail clippings in 52 children with psoriasis.
    Pediatr Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Division of Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Brasil.
    Background/objectives: Nail clipping, the act of cutting the distal portion of a nail for microscopic analysis, can complement the diagnosis of skin diseases with nail involvement, such as psoriasis. This study aimed to describe histopathologic findings on 81 nails from 52 children and adolescents with skin psoriasis and to determine whether these changes correlated with the severity of skin and nail involvement.

    Methods: Children with psoriasis were enrolled in this cross-sectional study to obtain Psoriasis Area and Severity Index (PASI) and Nail Psoriasis Severity Index (NAPSI) scores. Read More

    In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails.
    J Dermatolog Treat 2018 Jan 10:1-4. Epub 2018 Jan 10.
    d Medical Affairs , Sandoz Pharmaceuticals Inc , Princeton , NJ , USA.
    Background: Topical antifungal treatments for onychomycosis are applied to clean, unpolished nails for 48 weeks or longer. Patients often wish to mask their infection with nail polish yet there is no evidence to suggest antifungal efficacy in the presence of nail polish.

    Objective: To determine if tavaborole retains the ability to penetrate the nail plate and inhibit fungal growth in the presence of nail polish. Read More

    Ultrasound-Enhanced Drug Delivery for Treatment of Onychomycosis.
    J Ultrasound Med 2017 Dec 30. Epub 2017 Dec 30.
    Departments of Biomedical Engineering, George Washington University, Washington, DC, USA.
    Objectives: The aim of our study was to determine the effectiveness of using ultrasound (US) to increase the permeability of the nail, with the goal of improving outcomes in the treatment of onychomycosis.

    Methods: Porcine nails were used because of their similarity to human nails. A hydrophilic blue dye was used as a drug-mimicking compound. Read More

    Toenail onychomycosis by Trichophyton rubrum and concurrent infestation with Tyrophagus putrescentiae.
    Infez Med 2017 Dec;25(4):377-380
    Dipartimento di Scienze Chirurgiche e Biomediche, Clinica Dermatologica di Terni, Università degli Studi di Perugia, Terni, Italy.
    A remarkable case of onychomycosis by Trichophyton (T.) rubrum combined with nail infestation by Tyrophagus (T.) putrescentiae in an elderly diabetic farmer is described and discussed. Read More

    Singlet oxygen luminescence kinetics under PDI relevant conditions of pathogenic dermatophytes and molds.
    J Photochem Photobiol B 2018 Jan 14;178:606-613. Epub 2017 Dec 14.
    Department of Physics, Humboldt-Universität zu Berlin, Newtonstraße 15, 12489 Berlin, Germany. Electronic address:
    A treatment of onychomycosis using the photodynamic effect would be a favorable alternative to currently used antimycotic drugs. This study should be considered as a first step towards development and control of an efficient photodynamic inactivation of onychomycosis causative pathogens. Here, we evaluate the usage of time-resolved 2D singlet oxygen luminescence detection in combination with 2D fluorescence scanning as a tool to understand the behavior of the photosensitizer when applied to fungi on Petri dishes. Read More

    Long-Term Follow-up of Onychomycosis Patients Treated With Efinaconazole
    J Drugs Dermatol 2017 12;16(12):1269-1273
    Background: Onychomycosis is a common disease that remains difficult to treat despite the introduction of new topical agents. Clinical trials on efinaconazole and tavaborole included 48 weeks' daily treatment regimens with a 4-week follow-up. It has been suggested that either a longer treatment regimen or longer follow-up would lead to even better results, primarily due to the time taken for the diseased nail to grow out, especially in those patients with more severe disease. Read More

    Light treatments of nail fungal infections.
    J Biophotonics 2017 Dec 11. Epub 2017 Dec 11.
    School of Science and Health, Western Sydney University, Penrith, NSW, Australia.
    Nail fungal infections are notoriously persistent and difficult to treat which can lead to severe health impacts, particularly in the immunocompromized. Current antifungal treatments, including systemic and topical drugs, are prolonged and do not effectively provide a complete cure. Severe side effects are also associated with systemic antifungals, such as hepatotoxicity. Read More

    Randomized Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy with Short-Pulsed 1,064-nm Neodymium-Doped Yttrium Aluminium Garnet Laser and Amorolfine Nail Lacquer for Onychomycosis.
    Ann Dermatol 2017 Dec 30;29(6):699-705. Epub 2017 Oct 30.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Background: Onychomycosis is one of the most prevalent fungal diseases in the general population. However, treatment is of limited effectiveness and must be administered for long periods of time. Systemic antifungal agents are associated with adverse effects. Read More

    Luliconazole, a new antifungal against Candida species isolated from different sources.
    J Mycol Med 2017 Nov 29. Epub 2017 Nov 29.
    Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Golestan BLV, Ahvaz, Iran. Electronic address:
    Objective: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials. Read More

    Complete cure of Fusarium solani sp. complex onychomycosis with Qs NdYAG treatment.
    Dermatol Ther 2017 Nov 28. Epub 2017 Nov 28.
    Department of Dermatology, Dr. RML Hospital and PGIMER, New Delhi, India.
    The incidence of non dermatophytic mould (NDM) onychomycosis (OM) has been steadily increasing Fusarium spp is the most common cause of NDM OM in most geographical locations. Fusarium spp and other NDMs are largely resistant to commonly used anti-fungals. The successful use of laser and light based devices has been demonstrated in dermatophytic OM, but there is no previous report of their successful use in any NDM OM. Read More

    Evaluation of a new fluorescent reagent, fluorescent brightener 85, for the diagnosis of suspected onychomycosis compared with potassium hydroxide.
    Mycoses 2017 Nov 29. Epub 2017 Nov 29.
    Department of Clinical Laboratory, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
    Onychomycosis is a common fungal infection in dermatology clinics. The commonly used diagnostic method, potassium hydroxide (KOH) direct microscopy, does not have a high-positive detection rate. Therefore, a new diagnostic method is needed to confirm onychomycosis. Read More

    Onychomycosis and Chronic Fungal Disease: Exploiting a Commensal Disguise to Stage a Covert Invasion.
    J Cutan Med Surg 2017 Nov 1:1203475417745827. Epub 2017 Nov 1.
    3 Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
    Onychomycosis is a chronic fungal infection that is recalcitrant to treatment and often results in relapse. New evidence suggests that disease prognosis may be linked to pathogens manipulating host immune responses. Therefore, individuals with specific mutations, including those affecting pattern recognition receptors or the interleukin (IL)-17 and IL-22 pathways, may be more susceptible to infection. Read More

    Subungual onychomycosis due to Aspergillus niger mimicking a glomus tumor: A case report.
    Biomed Rep 2017 Dec 29;7(6):532-534. Epub 2017 Sep 29.
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Edobashi, Tsu-city, Mie 514-8507, Japan.
    Onychomycosis is a common nail infection caused by dermatophytes, while non-dermatophytes including Aspergillus spp. are causes of nail onychomycosis. Aspergillus niger is not common as a cause of nail onychomycosis. Read More

    [Affinity of Luliconazole for Human Nail Derived Keratin].
    Med Mycol J 2017 ;58(4):J113-J119
    Nihon Nohyaku Co., Ltd.
     Affinity of Luliconazole (LLCZ), an antifungal drug used for topical treatment of onychomycosis in Japan, to nail keratin was demonstrated. Efinaconazole (EFCZ) was used as a reference drug. Drugs at fixed concentrations were added to 4 ml of buffer solution containing 40 mg of nail keratin powder prepared from healthy volunteers or from tinea unguium patients. Read More

    The role of dermoscopy in the diagnosis of distal lateral subungual onychomycosis.
    Arch Dermatol Res 2018 Jan 24;310(1):57-69. Epub 2017 Nov 24.
    Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.
    Recently dermoscopic patterns, that can be useful in the diagnosis of distal and lateral subungual onychomycosis, were identified. In this study, we aimed to determine the frequency of the defined patterns so far and additionally to identify other patterns that were observed and to investigate the place of these patterns in the diagnosis of Distal Lateral Subungual Onychomycosis (DLSO) in the dermoscopic examination of the patients with pre-diagnosis of DLSO. Patients admitted dermatology outpatient clinic of Haydarpasa Numune Training and Research Hospital with the complaint of nail disturbance suspicious for DLSO (97 patients) between the August 2015 and February 2016. Read More

    Distal Lateral Subungual Onychomycosis Owing to Tritirachium oryzae: A Bystander or Invader?
    Mycopathologia 2017 Nov 21. Epub 2017 Nov 21.
    Mycology division, Department of Medical Microbiology, PGIMER, Chandigarh, 160012, India.
    The genus Tritirachium is a mitosporic fungus which inhabits in soil and decaying plant material and also a notable insect pathogen. Human infections with Tritirachium species though rare were previously reported to cause corneal ulcers, otomycosis, onychomycosis, and dermatomycosis of the scalp and hence may be considered as a potential pathogen. Here we report a case of distal lateral subungual onychomycosis involving right great toenail in a 22-year-old female, wherein direct potassium hydroxide preparations, fungal cultures, and molecular sequencing of the isolate established Tritirachium oryzae as the etiological agent. Read More

    A Review of Onychomycosis Due to Aspergillus Species.
    Mycopathologia 2017 Nov 16. Epub 2017 Nov 16.
    The National Aspergillosis Centre, Education and Research Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.
    Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. Read More

    SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis.
    Curr Pharm Des 2017 Nov 14. Epub 2017 Nov 14.
    Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goias, Rua 240, esq. com 5ª Avenida, Setor Leste Universitario, 74605-170, Goiania, GO. Brazil.
    Background: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. Read More

    Optimized Ciclopirox-Based Eudragit RLPO Nail Lacquer: Effect of Endopeptidase Enzyme as Permeation Enhancer on Transungual Drug Delivery and Efficiency Against Onychomycosis.
    AAPS PharmSciTech 2017 Nov 14. Epub 2017 Nov 14.
    Pharmaceutic Department, National Organization for Drug Control and Research, Giza, Egypt.
    The aims of our investigation were to develop and optimize ciclopirox (CPX) nail lacquer using nonbiodegradable Eudragit RLPO (E-RLPO) as a film former and to assess its penetration efficiency across the human nail plate. Preliminary trials such as hydration enhancement factor (HEF), a retained drug in the nail plate, and SEM were studied to select the optimized permeation enhancer to be incorporated in the optimized lacquer formulation. A 33 full factorial design was built up to study the effect of three different factors, concentration of E-RLPO (10, 20, and 30%), Tween 80 (0. Read More

    Clinical trial designs for topical antifungal treatments of onychomycosis and implications on clinical practice.
    Cutis 2017 Oct;100(4):259-264
    Pinehurst Skin Center, North Carolina, USA.
    There currently are 3 topical agents approved by the US Food and Drug Administration (FDA) to treat onychomycosis: tavaborole, efinaconazole, and ciclopirox. The phase 3 clinical trial designs for these treatments and their notable differences make it difficult for clinicians to interpret the data into clinical practice. For example, the primary end point predominantly used to assess efficacy in all the trials is complete cure, defined as no involvement of the nail plus mycologic cure; also, a notable number of patients fail to achieve a complete cure despite clear improvement in the nail. Read More

    Enhancement of tioconazole ungual delivery: Combining nanocapsule formulation and nail poration approaches.
    Int J Pharm 2018 Jan 7;535(1-2):237-244. Epub 2017 Nov 7.
    Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom. Electronic address:
    This work investigated the impact of formulation including in vitro release profile, repeated dosing, and nail poration on the ex vivo nail delivery performance of antifungal formulations. Chitosan coated and uncoated tioconazole-loaded nanocapsules and a nano-based film-forming vehicle were assessed via in vitro release and in vitro permeation tests using an artificial membrane and human nail clippings, respectively. The later involved single and daily dosing experiments with intact and porated nails. Read More

    [Clinical and mycological characteristics of onychomycosis due to Candida at Institut Pasteur of Côte d'Ivoire].
    J Mycol Med 2017 Nov 7. Epub 2017 Nov 7.
    Unité de mycologie, institut Pasteur, 01 BP 490, Abidjan, Côte d'Ivoire.
    Objective: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire.

    Patients And Methods: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded.

    Results: In this study, 1898 patient files were selected. Read More

    Risk of Psoriasis Following Terbinafine or Itraconazole Treatment for Onychomycosis: A Population-Based Case-Control Comparative Study.
    Drug Saf 2017 Nov 6. Epub 2017 Nov 6.
    Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan.
    Introduction: Several case studies have reported an association between antifungal drug use and psoriasis risk.

    Objective: The objective of this study was to investigate the association between terbinafine/itraconazole exposure and psoriasis incidence.

    Methods: Among patients with onychomycosis in the Taiwan National Health Insurance Research Database, 3831 incident psoriasis cases were identified during 2004-2010 and compared with 3831 age- and sex-matched controls with the same look-back period. Read More

    In Vitro Human Onychopharmacokinetic and Pharmacodynamic Analyses of ME1111, a New Topical Agent for Onychomycosis.
    Antimicrob Agents Chemother 2018 Jan 21;62(1). Epub 2017 Dec 21.
    University of California, San Francisco, San Francisco, California, United States.
    ME1111 is a novel antifungal agent currently under clinical development as a topical onychomycosis treatment. A major challenge in the application of topical onychomycotics is penetration and dissemination of antifungal agent into the infected nail plate and bed. In this study, pharmacokinetic/pharmacodynamic parameters of ME1111 that potentially correlate with clinical efficacy were compared with those of marketed topical onychomycosis antifungal agents: efinaconazole, tavaborole, ciclopirox, and amorolfine. Read More

    Clinico-aetiologic profile of Onychomycoses in a tertiary care centre in northeast India.
    Trop Doct 2017 Jan 1:49475517735979. Epub 2017 Jan 1.
    5 Senior Resident (Microbiology), 56918 NEIGRIHMS , Shillong, India.
    Onychomycosis refers to fungal nail infection. Despite a clearly diseased appearance, it is often deemed a merely cosmetic problem of relatively minor importance. However, it may result in much psychological or occupational turmoil, diminished self-esteem and resulting reluctance for public interaction. Read More

    Point-of-Care Diagnosis of Onychomycosis by Dermoscopy.
    J Am Podiatr Med Assoc 2017 Sep;107(5):413-418
    Background: Onychomycosis is one of the most common diseases of the toenails. The costs of diagnosis and treatment are substantial, and as the population ages, the overall cost burden will continue to escalate. The purpose of this study was to correlate dermoscopic features with pathologic diagnosis to support the accuracy of point-of-care diagnosis by dermoscopic examination. Read More

    Precise laser poration to control drug delivery into and through human nail.
    J Control Release 2017 Dec 16;268:72-77. Epub 2017 Oct 16.
    Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK; Centre for Nanoscience & Nanotechnology, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address:
    Drug treatment of diseases of the human nail remains a difficult challenge; topical therapy, in particular, is limited by very poor transport of active agents across the nail itself. The objective of this research was to examine the potential of controlled, and fibre-optic delivered, femtosecond laser light pulses to provide new pathways and opportunities for drug access to targets within and beneath the nail plate. Optical, confocal fluorescence and scanning electron microscopies demonstrated partial and complete laser poration of human nail samples, with the energy per pore and the exposure duration being the key modulating parameters that determined the extent of ablation achieved. Read More

    Management of mycoses in daily practice.
    G Ital Dermatol Venereol 2017 Dec;152(6):642-650
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, IRCCS Foundation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy -
    The guideline recommendations, albeit founded on thorough reviews of clinically relevant literature data, are often not immediately adaptable to everyday life. Considering the marked heterogeneity of superficial mycoses, each of them requires specific management in a real life context; in all cases diagnostic confirmation is required with microscopic and culture examination. In tinea capitis oral therapy is necessary (minimum six weeks) and should be continued until clinical and, above all, mycological healing. Read More

    Tavaborole in Difficult-to-Treat Onychomycosis Cases: A Post-hoc Assessment of Phase III Subjects.
    J Drugs Dermatol 2017 Oct;16(10):1016-1021
    Toenail onychomycosis is a chronic fungal infection that often requires prolonged treatment in order to effectively manage pathogenic organisms and obtain a clear nail. Traditionally, certain clinical features of onychomycosis, including the presence of substantial lateral disease, focal fungal masses, yellow/brown streaks, and extensive nail involvement (ie, >50%), indicate a poor treatment prognosis and have proven difficult-to-treat with oral or traditional topical therapies. Owing to the novel features of topical tavaborole, we sought to understand the potential utility of tavaborole in difficult-to-treat onychomycosis. Read More

    Treatment of Dermatophytosis in Elderly, Children, and Pregnant Women.
    Indian Dermatol Online J 2017 Sep-Oct;8(5):310-318
    Department of Dermatology, Venereology and Leprology, PGIMER, Chandigarh, India.
    Dermatophytic infection of the skin and its appendages is a common occurrence. Though usually straightforward, treatment of dermatophytosis becomes notably challenging in certain population groups - pregnant women, children, and elderly. Treatment with topical azoles/allylamines alone is effective in limited cutaneous disease in all three groups. Read More

    1340nm LASER THERAPY FOR ONYCHOMYCOSIS: Negative Results of Prospective Treatment of 72 Toenails and a Literature Review.
    J Clin Aesthet Dermatol 2017 Aug 1;10(8):56-61. Epub 2017 Aug 1.
    Drs. Espírito-Santo, Leite, Hoffmann-Santos, Dias, and Hahn are with the Faculty of Medicine, Post Graduate in Health Sciences at the Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil.
    Onychomycosis is an infection of the nail plate by fungal microorganisms. This infection has an important social impact on women and men and poses a major challenge for its treatment. The traditional treatment of onychomycosis involves the use of topical and oral antifungal agents. Read More

    Antibiofilm activity of propolis extract on Fusarium species from onychomycosis.
    Future Microbiol 2017 Nov 4;12:1311-1321. Epub 2017 Oct 4.
    Laboratory of Medical Mycology, Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá (UEM), Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil.
    Aim: The present study evaluated the capacity of three species of Fusarium isolated from onychomycosis to form biofilms and the antibiofilm effect of propolis extract on these biofilms.

    Materials & Methods: The biofilms and antibiofilm effects were evaluated by quantifying the colony-forming units, mitochondrial metabolic activity assays, total biomass by crystal violet staining and scanning electron microscopy.

    Results: Propolis extract demonstrated significant antibiofilm efficiency on Fusarium spp. Read More

    Draft Genome Sequences of Trichophyton rubrum CMCC(F)T1i and Trichophyton violaceum CMCC(F)T3l by Illumina 2000 and Pacific Biosciences.
    Genome Announc 2017 Sep 28;5(39). Epub 2017 Sep 28.
    Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China
    One strain of Trichophyton rubrum CMCC(F)T1i (=CBS 139224) isolated from onychomycosis and one strain of Trichophyton violaceum CMCC(F)T3l (=CBS 141829) isolated from tinea capitis in China were whole-genome sequenced by Illumina/Solexa, while the former was also sequenced by Pacific Biosciences sequencing in parallel. Read More

    Confirmatory Testing Prior to Initiating Onychomycosis Therapy Is Cost-Effective.
    J Cutan Med Surg 2017 Sep 1:1203475417733461. Epub 2017 Sep 1.
    3 Department of Medicine (Dermatology, Clinical Pharmacology and Toxicology) and Department of Pharmacology, Sunnybrook and Women's College Health Science Centre and the University of Toronto, Toronto, ON, Canada.
    Background: Onychomycosis can be investigated by sampling. Information gleaned includes nail bed involvement, nail plate penetration, fungal viability, and species identification. Testing samples can confirm a diagnosis. Read More

    In vitro biofilms and antifungal susceptibility of dermatophyte and non-dermatophyte moulds involved in foot mycosis.
    Mycoses 2018 Feb 15;61(2):79-87. Epub 2017 Oct 15.
    Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
    Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non-dermatophyte moulds are aetiological agents of foot mycosis and are capable of forming biofilms. Fungal biofilm has demonstrated increasing drug resistance. Read More

    Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis.
    Mycoses 2017 Dec 19;60(12):800-807. Epub 2017 Sep 19.
    Galderma International, Paris, France.
    Patient adherence is a key consideration in the choice of a topical regimen for the treatment of onychomycosis. The objective of this study was to investigate patient-reported outcomes (treatment utilisation, adherence and satisfaction) in onychomycosis treated with once-weekly amorolfine 5% nail lacquer versus once-daily ciclopirox 8% nail lacquer (Study A) or once-daily urea 40% ointment/bifonazole 1% cream combination regimen (Study B). Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks. Read More

    A pilot single centre, double blind, placebo controlled, randomized, parallel study of Calmagen® dermaceutical cream and lotion for the topical treatment of tinea and onychomycosis.
    BMC Complement Altern Med 2017 Sep 18;17(1):464. Epub 2017 Sep 18.
    Xerion Limited, Brighton, Victoria, 3186, Australia.
    Background: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis).

    Methods: A randomized, placebo-controlled, double blind, parallel, single centre study was conducted on 28 subjects with severe to very severe tinea or onychomycosis. Read More

    New insight into the pathogenesis of nail psoriasis and overview of treatment strategies.
    Drug Des Devel Ther 2017 30;11:2527-2535. Epub 2017 Aug 30.
    Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
    Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Read More

    New formulation for topical treatment of onychomycoses.
    G Ital Dermatol Venereol 2017 Oct;152(5):432-435
    Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
    Background: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient. Read More

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