3,981 results match your criteria Onychomycosis


Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining.

Sci Rep 2018 Dec 14;8(1):17840. Epub 2018 Dec 14.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rules in multiple sequential data sets. Read More

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http://dx.doi.org/10.1038/s41598-018-35909-zDOI Listing
December 2018

Polyurethanes as New Excipients in Nail Therapeutics.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Research Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal.

Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040276DOI Listing
December 2018
1 Read

Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.

Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040273DOI Listing
December 2018

Toenail alterations in chronic venous disease patients are not always of mycotic origin.

Phlebology 2018 Dec 12:268355518818619. Epub 2018 Dec 12.

1 Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Objective: The prevalence of toenail alterations in chronic venous disease has only rarely been studied. We aimed to establish the frequency and clinical characteristics of toenail onychomycosis in chronic venous disease.

Methods: We included 80 adult patients, in all stages of chronic venous disease. Read More

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http://dx.doi.org/10.1177/0268355518818619DOI Listing
December 2018

Allergic contact dermatitis due to undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Undecylenic acid (CAS no. 112-38-9) has antifungal and antibacterial effects. For this reason, it is used along with imidazole antifungals. Read More

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http://dx.doi.org/10.1111/cod.13195DOI Listing
December 2018
1 Read

Fusarium oxysporum is an onychomycosis etiopathogenic agent.

Future Microbiol 2018 Dec 3. Epub 2018 Dec 3.

Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá (UEM), Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil.

Aim: To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source.

Materials & Methods: The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscopy (SEM), CFU, matrix, histopathology and Fourier Transform Infrared Spectrometer coupled to an equipment with diamond accessory (FTIR-ATR).

Results: F. Read More

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http://dx.doi.org/10.2217/fmb-2018-0245DOI Listing
December 2018
1 Read

Propolis for the Treatment of Onychomycosis.

Indian J Dermatol 2018 Nov-Dec;63(6):515-517

Department of Clinical Analysis and Biomedicine, State University of Maringá, Paraná, Brazil.

Onychomycosis is a fungal nail infection, considered as a public health problem because it is contagious and it interferes with the quality of life. It has long and difficult treatment, with many side effects and high cost. Propolis extract (PE) is a potential alternative to conventional antifungal agents because it has low cost, accessibility, and low toxicity. Read More

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http://dx.doi.org/10.4103/ijd.IJD_365_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233048PMC
December 2018

Frequency of Fungal Species of Onychomycosis between Diabetic and Non-Diabetic Patients.

Mymensingh Med J 2018 Oct;27(4):752-756

Dr Sharmin Sultana, Medical Officer, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Onychomycosis is a common nail problem in our country. Diabetic patients are more prone to develop onychomycosis. Various types of fungi are the causative agents of nail infections. Read More

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October 2018

Analysis of the role of nail polish in the transmission of onychomycosis.

An Bras Dermatol 2018 Nov/Dec;93(6):930-931

Interdisciplinary Field of Biomedical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande (RS), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20187791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256209PMC
October 2017

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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http://dx.doi.org/10.5826/dpc.0804a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246064PMC
October 2018
2 Reads

A Comparative Study of Onychomycosis and Traumatic Toenail Onychodystrophy Dermoscopic Patterns.

J Eur Acad Dermatol Venereol 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Background: Onychomycosis (OM) and traumatic onychodystrophy (OD) are common causes of toenail changes. A clinical diagnosis is often impossible without mycology. Dermoscopy is helpful in this setting but yet under-explored. Read More

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http://dx.doi.org/10.1111/jdv.15358DOI Listing
November 2018

A survey among dermatologists: diagnostics of superficial fungal infections - what is used and what is needed to initiate therapy and assess efficacy?

J Eur Acad Dermatol Venereol 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Kings College Hospital NHS Trust, London, UK.

Background: Superficial fungal infections are common. It is important to confirm the clinical diagnosis by mycological laboratory methods before initiating systemic antifungal treatment, especially as antifungal sensitivity and in vitro susceptibility may differ between different genera and species. For many years, the gold standard for diagnosis of superficial fungal infections has been direct fungal detection in the clinical specimen (microscopy) supplemented by culturing. Read More

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http://dx.doi.org/10.1111/jdv.15361DOI Listing
November 2018
4 Reads

A Practical Guide to Curing Onychomycosis: How to Maximize Cure at the Patient, Organism, Treatment, and Environmental Level.

Am J Clin Dermatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Onychomycosis is a fungal nail infection caused by dermatophytes, non-dermatophyte molds, and yeasts. Treatment of this infection can be difficult, with relapse likely to occur within 2.5 years of cure. Read More

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http://dx.doi.org/10.1007/s40257-018-0403-4DOI Listing
November 2018
3 Reads

Mobile Phone Reminders for Onychomycosis Medication Adherence.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Weill Cornell Medicine, Department of Dermatology, NY, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.11.010DOI Listing
November 2018

Ultrasound-Enhanced Ciclopirox Delivery for Treatment of Onychomycosis.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:5717-5720

The study aim was to determine ultrasound's efficacy in increasing the permeability of the nail in order to improve treatment outcomes in onychomycosis. Three sets of ultrasound experiments were performed - the luminosity experiment and two sets of diffusion cell experiments. The luminosity experiments assessed dye levels inside the nail after ultrasound application as compared to sham treatments, and the diffusion cell experiments compared changes in nail permeability due to the application of ultrasound. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8513552DOI Listing

Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.

Mycoses 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

Background: Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. Read More

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http://dx.doi.org/10.1111/myc.12870DOI Listing
November 2018
1 Read

Update on current approaches to diagnosis and treatment of onychomycosis.

Expert Rev Anti Infect Ther 2018 Dec 13;16(12):929-938. Epub 2018 Nov 13.

b Division of Dermatology, Department of Medicine , University of Toronto School of Medicine , Toronto , Canada.

Introduction: Onychomycosis is a chronic fungal infection of the nail bed, matrix or plate. It accounts for roughly 50% of all nail disease. As the prevalence of onychomycosis is increasing, a critical review of diagnostic techniques and treatment options is required. Read More

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http://dx.doi.org/10.1080/14787210.2018.1544891DOI Listing
December 2018

The Impact of Onychomycosis on Quality of Life: A Systematic Review of the Available Literature.

Skin Appendage Disord 2018 Oct 13;4(4):208-216. Epub 2018 Feb 13.

Mediprobe Research Inc., London, Ontario, Canada.

Purpose: Onychomycosis is a nail disorder that is increasing in prevalence worldwide. The psychological and social limitations caused by onychomycosis can potentially undermine the work and social lives of those experiencing these negative effects. This review aimed to evaluate the randomized controlled trials (RCTs) available in the current literature on the impact onychomycosis has on quality of life (QoL). Read More

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http://dx.doi.org/10.1159/000485632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219228PMC
October 2018
5 Reads

In vitro photodynamic inactivation (PDI) of pathogenic germs inducing onychomycosis.

Photodiagnosis Photodyn Ther 2018 Dec 3;24:358-365. Epub 2018 Nov 3.

Department of Physics, Humboldt-Universität zu Berlin, Newtonstraße 15, 12489, Berlin, Germany. Electronic address:

Onychomycosis is a fungal nail infection caused primarily by the dermatophytes Trichophyton rubrum and Trichophyton interdigitale or, less frequently, by molds like Aspergillus spp. and Scopulariopsis brevicaulis. Photodynamic treatment of onychomycosis is considered a promising future therapy to overcome the frequent failure of currently used antifungals. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.11.002DOI Listing
December 2018

Epidemiological survey of onychomycosis pathogens in Japan by real-time PCR.

Med Mycol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, Teikyo University Mizonokuchi Hospital.

In Japan, an epidemiological survey of onychomycosis pathogens was performed using culture methods; however, the positive culture rate was 40% or less. As part of an epidemiological survey of dermatomycoses in Japan, we overcame this low positive rate by employing a real-time polymerase chain reaction (PCR) assay that allowed rapid and accurate detection and identification. In 2011, nail specimens were collected from patients at nine institutes in various prefectures in Japan and diagnosed as onychomycosis. Read More

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http://dx.doi.org/10.1093/mmy/myy096DOI Listing
October 2018

Topical urea in skincare: A review.

Authors:
Leonardo Celleno

Dermatol Ther 2018 Nov 30;31(6):e12690. Epub 2018 Oct 30.

Catholic University of Sacred Heart, Rome, Italy.

Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Read More

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http://doi.wiley.com/10.1111/dth.12690
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http://dx.doi.org/10.1111/dth.12690DOI Listing
November 2018
8 Reads

Treatment of onychomycosis using a 1064-nm diode laser with or without topical antifungal therapy: a single-center, retrospective analysis in 56 patients.

Eur J Med Res 2018 Oct 24;23(1):53. Epub 2018 Oct 24.

Department of Dermatology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.

Background: Currently available treatment options for onychomycosis such as topical and systemic antifungals are often of limited efficacy, difficult to administer or associated with relevant side effects. Non-ablative laser therapy is proposed to represent a safe alternative without the disadvantages of drugs. Yet, to date, the efficacy of laser therapy for onychomycosis is discussed controversially. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199788PMC
October 2018
4 Reads

Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan.

J Dermatol 2018 Oct 10. Epub 2018 Oct 10.

Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14677DOI Listing
October 2018
9 Reads

Nail clipping with onychomycosis and surprise clue to the diagnosis of nail unit melanoma.

J Cutan Pathol 2018 Nov;45(11):803-806

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1111/cup.13333
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http://dx.doi.org/10.1111/cup.13333DOI Listing
November 2018
6 Reads

Case Study of Onychomycosis Patients Treated with 1,064-nm Nd:YAG Laser.

Case Rep Dermatol 2018 May-Aug;10(2):216-225. Epub 2018 Aug 31.

Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.

Onychomycosis is the most frequent nail disease, with an estimated prevalence of 2-8%. Current treatment strategies include the use of oral and topical antifungals, despite low cure rates following these treatments. The objectives of this study were to assess the therapeutic response of patients with onychomycosis to 1,064-nm Nd:YAG laser treatment, the clinical evaluation method available for this therapy, and the possible side effects of this treatment. Read More

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http://dx.doi.org/10.1159/000492526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167730PMC
August 2018
8 Reads

Ultrasound Assessment of Psoriatic Onychopathy: A Cross-sectional Study Comparing Psoriatic Onychopathy with Onychomycosis.

Acta Derm Venereol 2018 Oct 3. Epub 2018 Oct 3.

Department of Rheumatology, Hospital Universitari Parc Tauli, Sabadell, Spain.

This cross-sectional study evaluated the usefulness of an ultrasound technique in assessment of nail changes in 35 patients with psoriatic onychopathy and 25 with nail dystrophy secondary to onychomycosis. All patients underwent 3 examinations: a complete clinical assessment; a nail ultrasound study; and fungal culture. Nails of patients with psoriatic onychopathy presented a thinner nail plate and nail bed, measured by ultrasound, than did those with onychomycosis. Read More

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http://dx.doi.org/10.2340/00015555-3060DOI Listing
October 2018
1 Read

[First report of a case of fungal keratitis due to Curvularia hominis in Spain].

Rev Iberoam Micol 2018 Jul - Sep;35(3):155-158. Epub 2018 Sep 28.

Servicio de Microbiología y Parasitología, Hospital Universitario de la Princesa, Madrid, España.

Background: Dematiaceous fungal genus Curvularia is a causal agent of keratitis, onychomycosis, and skin infections. In 2014, using DNA sequencing techniques, five new species, including Curvularia hominis, were described. In this article, a report is presented on the first clinical case of C. Read More

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http://dx.doi.org/10.1016/j.riam.2018.03.004DOI Listing
September 2018
1 Read

Coexistence of Fungal Infections in Psoriatic Nails and their Correlation with Severity of Nail Psoriasis.

Indian Dermatol Online J 2018 Sep-Oct;9(5):314-317

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Nail involvement in psoriasis is often complicated by concomitant fungal infections. The aim of this study was to investigate the prevalence of fungal infections in nail psoriasis and correlate it with the severity of nail psoriasis.

Materials And Methods: This retrospective study included patients with nail psoriasis aged ≥18 years with at least one fingernail and one toenail involvement who were treated at Siriraj Hospital from September 2012 to January 2014. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_192_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137661PMC
September 2018
9 Reads

Molecular identification and antifungal susceptibility of clinical fungal isolates from onychomycosis (uncommon and emerging species).

Mycoses 2018 Sep 25. Epub 2018 Sep 25.

Department of Medical Mycology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Onychomycosis is a common nail problem, accounting for up to 50% of all nail diseases. The aim of the present study was to determine the species distribution based on the restriction fragment length polymorphism and susceptibility patterns of the causative agents of onychomycosis. This cross-sectional study was conducted on nail samples collected from 257 patients suspected of onychomycosis during 14 months. Read More

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http://dx.doi.org/10.1111/myc.12854DOI Listing
September 2018
4 Reads
1.800 Impact Factor

Diagnostic values of KOH examination, histological examination, and culture for onychomycosis: a latent class analysis.

Int J Dermatol 2018 Sep 23. Epub 2018 Sep 23.

Department of Dermatology, Faculty of Medicine, Çukurova University, Adana, Turkey.

Background: In the absence of a real gold standard, comparative studies are still done on diagnostic methods for onychomycosis. There are only a few attempts using latent class analysis to determine the value of polymerase chain reaction in comparison to conventional methods. We aimed to determine the value of histological examination in such a way for the diagnosis of onychomycosis. Read More

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http://doi.wiley.com/10.1111/ijd.14255
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http://dx.doi.org/10.1111/ijd.14255DOI Listing
September 2018
3 Reads

Low Antifungal Activity of Tavaborole against Yeasts and Molds from Onychomycosis.

Antimicrob Agents Chemother 2018 Dec 26;62(12). Epub 2018 Nov 26.

Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

The activity of tavaborole, an FDA-approved antifungal drug, was compared to that of four antifungal agents against 170 clinical fungal isolates originating from patients with onychomycosis. Tavaborole had low activity against all isolates compared to itraconazole, terbinafine, and fluconazole, the principal choices for treatment of onychomycosis. Thus, it appears that tavaborole is not a candidate for the treatment of onychomycosis due to species, species, and dermatophytes. Read More

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http://dx.doi.org/10.1128/AAC.01632-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256807PMC
December 2018
1 Read
4.480 Impact Factor

Infrared spectroscopy as a novel tool to diagnose onychomycosis.

Br J Dermatol 2018 Sep 14. Epub 2018 Sep 14.

Department of Laboratory Medicine, Ghent University, Ghent, Belgium.

Background: The determination of causative organisms of onychomycosis is still not optimal. There remains a need for a cheap, fast and easy-to-perform diagnostic tool with a high capacity to distinguish between organisms.

Objectives: To determine whether attenuated total-reflectance Fourier transform infrared (ATR-FTIR) spectroscopy can detect and differentiate causative agents in culture-based, ex vivo nail and in vivo nail models. Read More

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http://dx.doi.org/10.1111/bjd.17199DOI Listing
September 2018

Common Foot Problems: Over-the-Counter Treatments and Home Care.

Am Fam Physician 2018 Sep;98(5):298-303

Virginia Commonwealth University Fairfax Family Practice, Fairfax, VA, USA.

Most foot disorders do not require podiatry referral or complex interventions. After the clinical diagnosis is made, these conditions can typically be managed with over-the-counter (OTC) and home remedies, with guidance from the primary care physician. Stretching and strengthening exercises, along with the use of heel cups, resolve most plantar fasciitis cases and are at least as effective as nonsteroidal anti-inflammatory drugs or steroid injections. Read More

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September 2018
2 Reads

NNTs Misleading for Onychomycosis Treatments.

Authors:
Chris Fallert

Am Fam Physician 2018 Jun;97(11):Online

St. Paul, MN, USA.

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June 2018
3 Reads

Terbinafine for Onychomycosis.

Am Fam Physician 2018 Aug;98(3):Online

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Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer.

Pharmaceutics 2018 Sep 11;10(3). Epub 2018 Sep 11.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.

Aqueous-based nail lacquers have shown potential in promoting the diffusion of drugs into the nail. In our laboratory, we have recently developed a transungual delivery system based on an aqueous dispersion of cyclodextrin-poloxamer soluble polypseudorotaxanes, supramolecular host-guest assemblies that improves the drug permeation into the nail. However, the high-water content and the rheological and adhesive properties of this lacquer negatively affect properties that play a fundamental role in the patients' acceptance such as stickiness, nail film formation or drying rate, properties. Read More

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http://dx.doi.org/10.3390/pharmaceutics10030156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160925PMC
September 2018
5 Reads

Onychomatricoma: A Rare Nail Tumor with an Unusual Clinical Presentation.

Skin Appendage Disord 2018 Aug 23;4(3):171-173. Epub 2017 Nov 23.

Fredric Brandt Endowed Professor of Dermatology, University of Miami, Miami, FL, USA.

First described in 1992, onychomatricoma is a rare, benign, fibroepithelial tumor of the nail matrix with few reported cases in the literature. The tumor predominately affects the fingers of Caucasian women during the 5th decade of life and is typically slow growing and painless. The authors present a unique clinical presentation of a giant onychomatricoma in a darker-skinned 60-year-old South Asian individual who presented with a large dome-shaped nail that was smooth, shiny, and green. Read More

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http://dx.doi.org/10.1159/000484577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120386PMC

A Retrospective Study Comparing K101 Nail Solution as a Monotherapy and in Combination with Oral Terbinafine or Itraconazole for the Treatment of Toenail Onychomycosis.

Skin Appendage Disord 2018 Aug 16;4(3):166-170. Epub 2017 Nov 16.

Department of Dermatology, University of Mississippi School of Medicine, Jackson, MS.

Background: Onychomycosis is a difficult-to-treat fungal infection of the nails. The efficacy of monotherapy is not ideal, and combination therapies provide an alternative that may increase treatment efficacy.

Method: A retrospective analysis of data from 91 patients was undertaken. Read More

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http://dx.doi.org/10.1159/000484211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120394PMC
August 2018
1 Read

Variability in Systemic Treatment Efficacy for Onychomycosis: Information That Clinical Studies Do Not Impart to the Office Dermatologist.

Skin Appendage Disord 2018 Aug 26;4(3):141-144. Epub 2017 Oct 26.

Division of Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Wide differences in the cure rates of onychomycosis in various clinical studies can be avoided if we bear in mind some insights that will help us make study results more consistent. We suggest less rigid criteria in defining the cure rate, the inclusion of all toenails in studies, and the exclusion of nails with a history of trauma. Rather than address patients as a homogenous group, regardless of age, we suggest dividing them into age groups. Read More

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http://dx.doi.org/10.1159/000481693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120383PMC
August 2018
1 Read

Antibiofilm Treatment for Onychomycosis and Chronic Fungal Infections.

Skin Appendage Disord 2018 Aug 11;4(3):136-140. Epub 2017 Oct 11.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Onychomycosis is a difficult-to-treat chronic fungal infection of the nail. The chronic nature of onychomycosis, with relevance to current treatment practices, could be attributed to host anergy, development of increased virulence in causal agents (multidrug resistance efflux pump), and biofilms. Biofilms must be disrupted prior to antifungal treatment suggesting the necessity of combination treatment. Read More

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http://dx.doi.org/10.1159/000480023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120382PMC
August 2018
2 Reads

Erratum for Mirhendi et al., the first case of onychomycosis in a koala due to atypical isolates of , a diagnostic challenge.

Curr Med Mycol 2018 Mar;4(1):35

General Medical Education and Research Center, Teikyo University, Tokyo, Japan.

[This corrects the article DOI: 10.18869/acadpub.cmm. Read More

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http://dx.doi.org/10.18502/cmm.4.1.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101153PMC
March 2018
1 Read

The Current Status and Perspectives of Delivery Strategy for Boron-based Drugs.

Curr Med Chem 2018 Sep 3. Epub 2018 Sep 3.

New Drug Research Institute, HEC Pharma Group, Dongguan 523871. China.

Boron-containing compounds are essential micronutrients for animals and plants despite their low-level natural occurrence. They can strengthen the cell walls of the plants and they play important role in supporting bone health. However, surprisingly, boron-containing compounds are seldom found in pharmaceutical drugs. Read More

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http://dx.doi.org/10.2174/0929867325666180904105212DOI Listing
September 2018
6 Reads
3.853 Impact Factor

[Laser Therapies for Onychomycosis in Japan].

Med Mycol J 2018 ;59(3):J45-J49

Department of Dermatology, Juntendo University Urayasu Hospital.

Various treatment methods other than oral and topical antifungal medications have been employed to treat onychomycosis. Treatment methods include mechanical removal of the affected part of the nail plate by using a toenail cutter or grinder and chemical removal by using occlusive dressing therapy with salicylic acid plaster or urea cream. In recent years, laser therapies have received attention as modalities for treatment of onychomycosis. Read More

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http://dx.doi.org/10.3314/mmj.18.007DOI Listing
October 2018
3 Reads

Use of in vitro performance models in the assessment of drug delivery across the human nail for nail disorders.

Expert Opin Drug Deliv 2018 Oct 7;15(10):983-989. Epub 2018 Sep 7.

a MedPharm Ltd , Guildford , UK.

Introduction: Onychomycosis is the most prevalent nail condition, affecting between 5% and 20% of the population in western countries. Oral therapies are not the treatment of choice due to poor patient compliance, high relapse rates, severe side effects, and contraindication. However, the difficultly in curing the condition using topical delivery is partly due to both the nail structure presenting a complex barrier and the lack of understanding of how best to achieve delivery of drug to the nail bed. Read More

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http://dx.doi.org/10.1080/17425247.2018.1518425DOI Listing
October 2018

Efficiency of methylene blue-mediated photodynamic therapy vs intense pulsed light in the treatment of onychomycosis in the toenails.

Photodermatol Photoimmunol Photomed 2018 Aug 31. Epub 2018 Aug 31.

Instituto de Química Física Rocasolano, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

Background: Photodynamic therapy (PDT) or intense pulsed light (IPL) are efficient therapeutic methods in the treatment of superficial skin infections, and thus, they could be good options for onychomycosis treatment, the most common nail disorder.

Methods: Forty patients, affected with different diagnosed types of onychomycosis in nails of the first toe, were randomly divided into two groups of 20 patients to be treated by PDT or IPL. Nail plates were softened with urea 40% by occlusive dressing for 12 hours during 3-7 days before treatments. Read More

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http://dx.doi.org/10.1111/phpp.12420DOI Listing
August 2018
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Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.

J Dermatol 2018 Oct 29;45(10):1151-1159. Epub 2018 Aug 29.

Sato Pharmaceutical Co., Ltd, Tokyo, Japan.

Fosravuconazole L-lysine ethanolate (F-RVCZ) is a prodrug of ravuconazole, a novel triazole antifungal agent, exerting broad and potent antifungal activity. The efficacy and safety of F-RVCZ, compared with a placebo, were investigated in a multicenter, double-blind, randomized study of Japanese onychomycosis patients with 25% or more clinical involvement of the target toenail. Subjects (n = 153) were randomly assigned to receive F-RVCZ (100 mg RVCZ, n = 101) or placebo (n = 52) p. Read More

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http://doi.wiley.com/10.1111/1346-8138.14607
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http://dx.doi.org/10.1111/1346-8138.14607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220848PMC
October 2018
19 Reads

Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent.

Front Med (Lausanne) 2018 14;5:227. Epub 2018 Aug 14.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris. Sixty seven ethnic Poles suffering from pemphigus vulgaris on photographic files archiving initial presentation were retrospectively evaluated. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2018.00227/
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http://dx.doi.org/10.3389/fmed.2018.00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102408PMC
August 2018
5 Reads

Detection of Trichophyton rubrum and Trichophyton interdigitale in onychomycosis using monoclonal antibodies against Sub6 (Tri r 2).

Mycoses 2018 Aug 28. Epub 2018 Aug 28.

Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Background: Onychomycosis is the most prevalent nail disease and is mainly caused by two dermatophyte species Trichophyton rubrum and Trichophyton interdigitale with a frequency in the range of 80% and 20%, respectively. The secreted protease Sub6 of the subtilisin family, which was never detected in vitro growth conditions, was found to be a robust marker of onychomycosis.

Objective: The aim of this work was to detect tinea unguium using anti-Sub6 monoclonal antibodies in proteins extracted from clinical nail samples. Read More

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http://doi.wiley.com/10.1111/myc.12843
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http://dx.doi.org/10.1111/myc.12843DOI Listing
August 2018
14 Reads

Onychomycosis caused by Aspergillus subramanianii.

J Dermatol 2018 Nov 25;45(11):1362-1366. Epub 2018 Aug 25.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

We describe a case of a 23-year-old female patient with no apparent underlying diseases. She showed a discoloration of the proximal portion of the left big toenail with paronychia. Direct microscopy revealed septate hyphae with conidiophores, and a periodic acid-Schiff-stained nail specimen revealed septate hyphae branching at angles of approximately 45°. Read More

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http://dx.doi.org/10.1111/1346-8138.14616DOI Listing
November 2018
7 Reads