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    3859 results match your criteria Onychomycosis

    1 OF 78

    Antimicrobial effects of photodynamic therapy: an overview.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    IIS Aragón, Zaragoza, Spain -
    The microorganisms that cause infections are increasing their resistance to antibiotics. In this context, alternative treatments are necessary. The antimicrobial photodynamic therapy (aPDT) is a therapeutic modality based on photosensitizing molecules that end up generating reactive oxygen species that induce the destruction of the target cells when are irradiated with light of a suitable wavelength and at a proper dose. Read More

    The role of biofilms in onychomycosis.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Mediprobe Research Inc., London, Canada.
    Onychomycosis is a difficult to treat fungal infection of the nails. The chronic nature of onychomycosis contributes to high recurrence rates and the difficulty in treating both dermatophyte and non- dermatophyte infections. It has been hypothesized that the formation of biofilms, sessile, multicellular communities of fungi surrounded by a protective extracellular matrix, allow for fungi to evade current antifungal therapies and contribute to observed antifungal resistance. Read More

    Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis.
    Indian J Pharmacol 2017 Nov-Dec;49(6):470-471
    Department of Dermatology, Nicolina Medical Centre, Apollonia University, "P.Poni" Research Institute of Macromolecular Chemistry, Lasi, Romania.
    We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment. Read More

    Microstructural alterations in the onychomycotic and psoriatic nail: relevance in drug delivery.
    Eur J Pharm Biopharm 2018 Apr 16. Epub 2018 Apr 16.
    Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Spain; Industrial Pharmacy Institute, University of Santiago de Compostela, Spain.
    Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered structure. This work aimed to characterize the microstructure of the healthy, onychomycotic and psoriatic human nail using Raman spectroscopy, scanning electron microscopy, optical microscope profilometry and mercury intrusion porosimetry followed by analysis of the structure with PoreCor® software. The results showed that onychomycotic nails have higher porosity and lower amounts of disulfide bonds compared to healthy nails. Read More

    [Effect of 0.9-ms 1064-nm Nd:YAG laser combined with itraconazole for treatment of toenail onychomycosis].
    Nan Fang Yi Ke Da Xue Xue Bao 2018 Mar;38(3):358-362
    1Department of Dermatology and Venerology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China; 2Southern Medical University, Guangzhou 510515, China. E-mail:
    Objective: To evaluate the efficacy and safety of 0.9-ms 1064-nm Nd:YAG laser alone or combined with itraconazole for treatment of toenail onychomycosis.

    Methods: A total of 37 patients with onychomycosis (178 toenails) were randomly assigned to groups A and B, and each group was further divided into different subgroups according to the Scoring Clinical Index of Onychomycosis (SCIO) and Onychomycosis Severity Index (OSI) scoring. Read More

    An amelanotic nail bed melanoma presenting as persistent onychodystrophy.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Medical College of Georgia at Augusta University, Augusta, Georgia.
    Nail apparatus melanomas are rare and may present with a wide variety of clinical presentations. In particular, the amelanotic subtype can pose a diagnostic challenge, often leading to a poor prognosis related to a delayed diagnosis. We report a 69-year-old man with an unusual subungual amelanotic melanoma presenting as a persistent single nail dystrophy that was repeatedly treated as onychomycosis. Read More

    The repurposing of ivermectin for malaria: a prospective pharmacokinetics-based virtual clinical trials assessment of dosing regimen options.
    J Pharm Sci 2018 Apr 4. Epub 2018 Apr 4.
    Aston Pharmacy School, Aston University, Birmingham, B4 7ET, United Kingdom.
    Ivermectin has demonstrated many successes in the treatment of a range of nematode infections. Considering the increase in malaria resistance attention has turned towards ivermectin as a candidate for repurposing for malaria. This study developed and validated an ivermectin physiologically-based pharmacokinetic model in healthy adults (20-50 years) and paediatric (3-5 years/15-25 kg) subjects and in a representative adult malaria population group (Thailand). Read More

    Proximal Subungual Onychomycosis in the Immunocompetent: A Case Report and Review of the Literature.
    J Drugs Dermatol 2018 Apr;17(4):475-478
    Proximal subungual onychomycosis (PSO), which predominantly involves the nail plate from the proximal nail fold, is the rarest form of onychomycosis. Classically associated with an immunocompromised state, PSO is an uncommon diagnosis in individuals without immunodeficiency. We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Read More

    Fungal diseases in children and adolescents in a referral centre in Bogota, Colombia.
    Mycoses 2018 Mar 30. Epub 2018 Mar 30.
    Dermatology Resident, Fundación Universitaria Sanitas, Centro Dermatológico Federico Lleras Acosta, E.S.E, Bogotá, D.C, Colombia.
    A cross-sectional descriptive study was conducted at a dermatology referral centre in Bogotá to estimate the frequencies and aetiologies of mycoses in the population under 18 years of age attending the medical mycology laboratory over a 13-year period (2000-2012). A total of 1337 samples from 1221 patients were evaluated, involving direct examination and culture for 1279 samples, direct examination alone for 50 and culture alone for 8. During the study period, dermatophytosis was diagnosed via culture in 537 cases (40. Read More

    [Tinea capitis and onychomycosis due to Trichophyton soudanense : Successful treatment with fluconazole-literature review].
    Hautarzt 2018 Mar 27. Epub 2018 Mar 27.
    Labor für medizinische Mikrobiologie, Partnerschaft Prof. Dr. med. Pietro Nenoff & Dr. med. Constanze Krüger, 04571, Rötha/OT Mölbis, Deutschland.
    Two African girls who moved to Germany only 4 weeks ago presented to the dermatological office with itchy and scaling skin lesions of the scalp and the thighs. The entire scalp of both girls was affected by a white, dry dandruff and a squamous crust. Dry centrifugal spreading erythematosquamous lesions were found on the thighs. Read More

    Perspective on Broad-Acting Clinical Physiological Effects of Photobiomodulation.
    Adv Exp Med Biol 2018 Mar 24. Epub 2018 Mar 24.
    Faculty of Health Sciences, University of Haifa, Haifa, Israel.
    Research into photobiomodulation reveals beneficial effects of light therapy for a rapidly expanding list of medical conditions and illnesses. Although it has become more widely accepted by the mainstream medicine, the effects and mechanisms of action appear to be poorly understood. The therapeutic benefits of photobiomodulation using low-energy red lasers extend far beyond superficial applications, with a well-described physics allowing an understanding of how red lasers of certain optimum intensities may cross the cranium. Read More

    Urinary tract infection due to Fusarium oxysporum in an immunocompetent patient with chronic kidney disease.
    J Biomed Res 2017 Nov 1. Epub 2017 Nov 1.
    Department of Microbiology, Government Medical College, Hanuman Nagar, Nagpur 440009, India.
    Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been described as a cause of urinary tract infection. Here, we present the first case of fusariosis with urinary tract involvement in a 67 year old male, with chronic kidney disease and type 2 diabetes mellitus. Read More

    Hair and nail diseases in the mature patient.
    Clin Dermatol 2018 Mar - Apr;36(2):159-166. Epub 2017 Oct 3.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
    The elderly population is growing, lifespans are increasing, and a greater emphasis on geriatric care is being implemented in hospital systems. With a higher percentage of the population living longer, hair and nail diseases associated with the advanced stages of life are becoming more prevalent. Common hair diseases in the elderly include androgenetic alopecia, senile alopecia, frontal fibrosing alopecia, and erosive pustular dermatosis of the scalp. Read More

    Validation of the Healthy Foot Screen: A Novel Assessment Tool for Common Clinical Abnormalities.
    Adv Skin Wound Care 2018 Apr;31(4):154-162
    Reneeka Persaud, MD, MScCH • Dalla Lana School of Public Health • University of Toronto • Research Coordinator • Toronto Regional Wound Healing Clinic • Adjunct Faculty • International Interprofessional Wound Care Course • Toronto, Ontario, Canada Patricia M. Coutts, RN • Wound Care & Clinical Trials Coordinator • Toronto Regional Wound Healing Clinic • Faculty • International Interprofessional Wound Care Course • Toronto, Ontario, Canada Alisa Brandon, BSc • Medical Student • Faculty of Medicine • University of Toronto • Toronto, Ontario, Canada Luvneet Verma, BSc • Medical Student • Faculty of Medicine • University of Ottawa • Ottawa, Ontario, Canada James A. Elliott, MSc • Faculty • International Interprofessional Wound Care Course • Member • Wounds Canada Research Committee • Toronto, Ontario, Canada R. Gary Sibbald, MD, MEd, BSc, FRCPC (Med Derm), MACP, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Previous President • World Union of Wound Healing Societies • Clinical Editor • Advances in Skin & Wound Care • Philadelphia, Pennsylvania.
    General Purpose: The purpose of this learning activity is to provide information about the Healthy Foot Screen, a new tool for assessment of common foot abnormalities.

    Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

    Learning Objectives/outcomes: After completing this continuing education activity, you should be able to:1. Read More

    Effectiveness of healthcare worker screening in hospital outbreaks with gram-negative pathogens: a systematic review.
    Antimicrob Resist Infect Control 2018 9;7:36. Epub 2018 Mar 9.
    2Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
    Background: Identifying the source of an outbreak is the most crucial aspect of any outbreak investigation. In this review, we address the frequently discussed question of whether (rectal) screening of health care workers (HCWs) should be carried out when dealing with outbreaks caused by gram negative bacteria (GNB).A systematic search of the medical literature was performed, including the Worldwide Outbreak Database and PubMed. Read More

    Tinea unguium onychomycosis caused by dermatophytes: a ten-year retrospective study (2005-2014) in a tertiary hospital in Singapore.
    Singapore Med J 2018 Mar 19. Epub 2018 Mar 19.
    Department of Microbiology, Singapore General Hospital, Singapore.
    Introduction: Tinea unguium is a common nail infection. We conducted a retrospective ten-year study of the patient demographics and species distribution of dermatophytes causing tinea unguium in a tertiary hospital from Singapore.

    Methods: Results of fungal nail cultures were retrieved from our hospital's microbiology department. Read More

    Examining the Benefits of the Boron-Based Mechanism of Action and Physicochemical Properties of Tavaborole in the Treatment of Onychomycosis.
    J Am Podiatr Med Assoc 2018 Jan;108(1):12-19
    Onychomycosis is a fungal infection of the nail primarily caused by the dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes. The topical-based treatment of onychomycosis remains a challenge because of the difficulty associated with penetrating the dense, protective structure of the keratinized nail plate. Tavaborole is a novel small-molecule antifungal agent recently approved in the United States for the topical treatment of toenail onychomycosis. Read More

    The Role of Scanning Electron Microscopy in the Direct Diagnosis of Onychomycosis.
    Scanning 2018 9;2018:1581495. Epub 2018 Jan 9.
    Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China.
    Purpose: The purpose of this study was to evaluate the role of scanning electron microscopy (SEM) in the direct diagnosis of suspected onychomycosis with negative mycological test results.

    Methods: Outpatients diagnosed with suspected onychomycosis with negative mycological test results, including direct microscopic examination with 10% potassium hydroxide (KOH) and fungal culture, on 3 separate occasions were recruited. A small piece of infected nail was obtained for SEM examination. Read More

    Topical Tavaborole in the Treatment of Onychomycosis Complicated by Dermatophytoma: A Post-hoc Assessment of Phase II Subjects.
    J Drugs Dermatol 2018 Mar;17(3):347-354
    Dermatophytoma is a little-known, difficult to treat fungal infection that complicates onychomycosis. First described by Roberts and Evans in the late 1990's, dermatophytoma presents as a dense concentration of fungal hyphae within or under the nail plate and is generally white or yellow/brown in color, and linear (streaks) or round (patches) in shape; primary etiologic organisms are dermatophytes. Oral antifungals have limited success in treating dermatophytoma owing to difficulties accessing and penetrating what is hypothesized to be a fungal biofilm. Read More

    Clinical Insights About Onychomycosis and Its Treatment: A Consensus.
    J Drugs Dermatol 2018 Mar;17(3):253-262
    Background: Recently, experience and knowledge have been gained using effective topical treatment for onychomycosis, a difficult-to-treat infection.

    Methods: This project aims to help understand and improve patient-focused quality of care for fungal nail infections. A panel of dermatologists who treat onychomycosis convened on several occasions to review and discuss recent learnings in the treatment of onychomycosis. Read More

    Polymerase Chain Reaction-Restriction Fragment Length Polymorphism as a Confirmatory Test for Onychomycosis.
    Open Access Maced J Med Sci 2018 Feb 14;6(2):280-283. Epub 2018 Feb 14.
    Universitas Sumatera Utara, Dermatology and Venereology, Medan, North Sumatera, Indonesia.
    Background: Onychomycosis is a fungal infection of one or more units of the nail caused by dermatophytes, or mould and nondermatophytes yeast. Investigations are needed to establish the diagnosis of onychomycosis before starting treatment. Several investigations methods for diagnosing onychomycosis are microscopic examination with 20% KOH, fungal culture, histopathology examination with PAS staining (Periodic acid Schiff) and PCR (Polymerase Chain Reaction). Read More

    A systematic approach to the formulation of anti-onychomycotic nail patches.
    Eur J Pharm Biopharm 2018 Mar 9. Epub 2018 Mar 9.
    Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:
    Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. Our aim was therefore to develop a systematic and novel approach to the formulation of a simple drug-in-adhesive ungual patch. Twelve pressure-sensitive adhesives (PSAs), four backing membranes, two release liners and three drugs were screened for pharmaceutical and mechanical properties. Read More

    Evaluation of the promoting effect of soluble cyclodextrins in drug nail penetration.
    Eur J Pharm Sci 2018 May 6;117:270-278. Epub 2018 Mar 6.
    Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Spain; Industrial Pharmacy Institute, University of Santiago de Compostela, Spain. Electronic address:
    Soluble derivatives of β-cyclodextrin (CD) have a high capacity to solubilise hydrophobic molecules and to interact with proteins and membrane component. As consequence CD derivatives shows a significant activity as drug absorption enhancers through different delivery routes, such as the oral, nasal, ocular or topical route. In this paper, the effect of two CD derivatives -methyl-β-cyclodextrin (MBCD) and hydroxypropyl-β-cyclodextrin (HPB)- on the structure and permeability of the nail plate has been studied using the drug model ciclopirox olamine. Read More

    Detection of some new Trichosporon species from the dystrophied nails of three female members of a family from North Indian State of Jammu and Kashmir.
    Mycoses 2018 Mar 3. Epub 2018 Mar 3.
    School of Biotechnology, University of Jammu, Jammu, India.
    Dermatophytes are considered as the main pathogens responsible for onychomycosis, but recently successive isolations of yeast-like fungi from the infected nails has led to consider these also as primary agents of nail infections. Trichosporon species which are non-candidal, basidiomycetous, yeast-like, anamorphic fungi are commonly isolated from soil but they are also emerging as important etiological agents of onychomycosis. Three species of Trichosporon viz. Read More

    Cutaneous manifestations of diabetic peripheral neuropathy.
    Dermatoendocrinol 2017 6;9(1):e1395537. Epub 2017 Dec 6.
    Department of Dermatology, Venereology and Leprosy, Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamilnadu, India.
    There is a rise in number of people diagnosed with Diabetes Mellitus. The incidence is rising in modern Indian society because of Industrial development and drastically changing lifestyles. Diabetic neuropathies are microvascular disorders that are usually associated with the duration of Diabetes. Read More

    Is Severity of Disease a Prognostic Factor for Cure Following Treatment of Onychomycosis?
    J Drugs Dermatol 2018 Feb;17(2):175-178
    Background: Onychomycosis is a common disease that remains a difficult disorder to treat despite the introduction of new topical agents; and not all patients are cured. Clinical experience leads us to suggest a number of host-related factors can affect the chance of cure, but studies supporting these observations are currently lacking. Although many studies, particularly on topical agents, rely on severity classification when selecting patients for inclusion, a pilot study was unable to demonstrate any prognostic value of the extension of nail involvement. Read More

    Planimetric Post-hoc Analysis of Women With Onychomycosis from Tavaborole 5% Phase III Studies: Evidence of Greater Improvements in Patients With >50% Baseline Infection.
    J Drugs Dermatol 2018 Feb;17(2):168-172
    Women with onychomycosis may suffer more effects on their quality of life than men. There is limited female-specific data on the treatment of onychomycosis. Tavaborole is a topical treatment option for onychomycosis. Read More

    Onychomycosis due to dermatophytes species in Iran: Prevalence rates, causative agents, predisposing factors and diagnosis based on microscopic morphometric findings.
    J Mycol Med 2018 Mar 12;28(1):45-50. Epub 2018 Feb 12.
    Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
    Objective: Onychomycosis (OM) or fungal nail infection is one of the most common fungal infections, which is increasingly prevalent. OM is caused by dermatophytes spp, yeasts and non-dermatophyte moulds (NDMs). The purpose of this study was to identify and determine the prevalence rates, predisposing factors and causative agents of OM using clinical symptoms and microscopic morphometric findings. Read More

    Phylogenetic Diversity and In Vitro Susceptibility Profiles of Human Pathogenic Members of the Fusarium fujikuroi Species Complex Isolated from South India.
    Mycopathologia 2018 Feb 14. Epub 2018 Feb 14.
    Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamilnadu, 600116, India.
    Availability of molecular methods, gene sequencing, and phylogenetic species recognition have led to rare fungi being recognized as opportunistic pathogens. Fungal keratitis and onychomycosis are fairly common mycoses in the tropics, especially among outdoor workers and enthusiasts. The frequently isolated etiological agents belong to genera Candida, Aspergillus, and Fusarium. Read More

    Dermoscopic Features of Distal Lateral Subungual Onychomycosis.
    Indian Dermatol Online J 2018 Jan-Feb;9(1):16-19
    Department of Dermatology, Yenepoya Medical College, Yenepoya University, Mangaluru, Karnataka, India.
    Background: Onychomycosis is a very common disease and accounts for upto 50% of the diseases affecting the nail apparatus. Diagnosis of onychomycosis is usually confirmed with the help of a potassium hydroxide (KOH) mount and fungal culture. Onychoscopy can be a handy and additional tool for the diagnosis. Read More

    [Dermatophytosis due to Trichophyton violaceum at the parasitology-mycology laboratory of the military hospital of Meknes (about twelve cases)].
    J Mycol Med 2018 Mar 9;28(1):1-7. Epub 2018 Feb 9.
    Laboratoire de parasitologie-mycologie, hôpital militaire d'instruction Moulay-Ismaïl, boulevard El Hansali, 50000 Meknès, Maroc. Electronic address:
    Introduction: Trichophyton violaceum is an anthropophilic dermatophyte, common in Mediterranean and African countries, which causes particularly trichophytic tinea in school-aged children. The objective of this work is to study the clinical and epidemiological profile of T. violaceum infections. Read More

    Nail Raman spectroscopy: A promising method for the diagnosis of onychomycosis. An ex vivo pilot study.
    Med Mycol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Skin and Venereal Diseases, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
    Trichophyton rubrum and Candida species comprise the majority of onychomycosis pathogens. The aim of this study was to evaluate Raman spectroscopy for the differentiation between healthy and either T. rubrum or Candida infected nails. Read More

    Onychoscopy of trachyonychia: An analysis of 30 patients and comparison with onychomycosis.
    Br J Dermatol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
    The diagnosis of trachyonychia is often challenging, and misdiagnoses, particularly as onychomycosis, are common. The correct diagnosis of trachyonychia is crucial because treatment options for trachyonychia include observation/active non-intervention, topical and systemic steroids, or immunomodulating agents, while onychomycosis should be treated with antifungal agents . Onychoscopy (nail dermoscopy) is a useful tool for various nail disorders. Read More

    [Prevalence of dermatomycoses in professional football players : A study based on data of German Bundesliga fitness check-ups (2013-2015) compared to data of the general population].
    Hautarzt 2018 Feb 7. Epub 2018 Feb 7.
    Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen (IVDP), Universitätsklinikum Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Deutschland.
    Background: The prevention, early diagnosis and treatment of onychomycosis is of great importance for professional athletes to avoid physical limitations by complications. So far, there is only little data on the prevalence of dermatomycosis in professional athletes.

    Objectives: The aim of the study was to detect the prevalence of dermatomycosis in professional football players compared to the general population. Read More

    Hábitos podológicos en personas con alteraciones ungueales.
    Gac Med Mex 2017 ;153(7):810-817
    Grupo de Investigación de Epidemiología Clínica, Departamento de Ciencias de la Salud, Facultad de Enfermería y Podología, UDC; Ferrol, A Coruña, España.
    Objective: To determine the prevalence of onychocryptosis and onychomycosis confirmed by culture in subjects attending a Podiatric University Hospital and to describe their podiatric habits.

    Method: Cross-sectional study of prevalence. The study was carried out at the Clinic University of Podology of A Coruna University (Ferrol, Spain). Read More

    Comparison of fungal fluorescent staining and ITS rDNA PCR-based sequencing with conventional methods for the diagnosis of onychomycosis.
    J Eur Acad Dermatol Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.
    Background: The current gold standard for diagnosing onychomycosis is direct microscopic examination and culturing. Fungal culture is a time-consuming procedure, while direct microscopy of potassium hydroxide (KOH) mounts suffers from low sensitivity. More rapid and sensitive methods for the diagnosis of onychomycosis are in high demand. Read More

    Factors Affecting Dermatological Manifestations in Patients with End Stage Renal Disease.
    J Coll Physicians Surg Pak 2018 Feb;28(2):98-102
    Statistician, Government MAO College, Lahore.
    Objective: To determine skin changes in patients of End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) and factors affecting these changes.

    Study Design: Cross-sectional observational study.

    Place And Duration Of Study: Nephrology Department, Mayo Hospital, Lahore in collaboration with Dermatology Department, King Edward Medical University, Lahore, from October 2015 to January 2016. Read More

    The frequency, antifungal susceptibility and enzymatic profiles of Candida species in cases of onychomycosis infection.
    Microb Pathog 2018 Mar 20;116:257-262. Epub 2018 Feb 20.
    Istanbul University, Cerrahpasa Medical Faculty, Department of Microbiology, Istanbul, Turkey.
    Although the frequency of candidal onychomycosis is increasing daily, there is little information in literature about the epidemiology, pathogenesis, and antifungal susceptibility of this dermatological disease. This study aimed to provide information about the epidemiology, pathogenesis, and azole susceptibility of Candida species isolated from patients living in a region with continental climate. After identification of the isolated strains using conventional methods, proteinase and phospholipase activities were determined by a plate method and biofilm-forming ability was determined using the microplate method. Read More

    Fungicidal Activity in the Presence of Keratin as an Important Factor Contributing to In Vivo Efficacy: A Comparison of Efinaconazole, Tavaborole, and Ciclopirox.
    J Fungi (Basel) 2017 Oct 19;3(4). Epub 2017 Oct 19.
    Pharmacology Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd. 14, Shinomiya, Minamigawara-cho, Yamashina-ku, Kyoto 607-8042, Japan.
    Use of oral antifungals in the treatment of onychomycosis is commonplace; but their use can be limited by safety and patient concerns. Due to their broader safety margins, topical antifungals (efinaconazole, tavaborole, and ciclopirox) are a useful option in the treatment of mild-to-moderate onychomycosis in the USA, but their antifungal activity has yet to be directly compared. This study aims to identify important factors contributing to in vivo efficacies of the three topical antifungals. Read More

    An Assessment of In Vitro Antifungal Activities of Efinaconazole and Itraconazole against Common Non-Dermatophyte Fungi Causing Onychomycosis.
    J Fungi (Basel) 2017 May 5;3(2). Epub 2017 May 5.
    Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai Tamilnadu 600116, India.
    Onychomycosis is a fungal nail infection which is relatively common and difficult to treat. Treatment modalities include nail avulsion, surgical debridement and combination therapy with oral and topical antifungal drugs. In spite of a host of available drugs, clinical cure rates remain discouraging. Read More

    Oral Medications to Treat Toenail Fungal Infection.
    JAMA 2018 Jan;319(4):397-398
    Primary Care Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Australia.
    Clinical Question: Which oral antifungal medication is associated with the highest clinical (ie, normal appearance of the toenail) and mycological (negative culture, microscopy, or both) cure rates vs placebo or other antifungals when used to treat fungal infections?

    Bottom Line: Both terbinafine and azole-based medications were associated with higher clinical and mycological cure rates compared with placebo (high-quality evidence). Azoles were associated with lower cure rates than terbinafine when compared directly. Read More

    Deep neural networks show an equivalent and often superior performance to dermatologists in onychomycosis diagnosis: Automatic construction of onychomycosis datasets by region-based convolutional deep neural network.
    PLoS One 2018 19;13(1):e0191493. Epub 2018 Jan 19.
    Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
    Although there have been reports of the successful diagnosis of skin disorders using deep learning, unrealistically large clinical image datasets are required for artificial intelligence (AI) training. We created datasets of standardized nail images using a region-based convolutional neural network (R-CNN) trained to distinguish the nail from the background. We used R-CNN to generate training datasets of 49,567 images, which we then used to fine-tune the ResNet-152 and VGG-19 models. Read More

    Onychomycosis Caused by spp. in Dakar, Senegal: Epidemiological, Clinical, and Mycological Study.
    Dermatol Res Pract 2017 4;2017:1268130. Epub 2017 Dec 4.
    Laboratoire de Parasitologie-Mycology, CHU Le Dantec, BP 5005, Dakar, Senegal.
    spp. represent 9 to 44% of onychomycoses caused by other than dermatophytes. This retrospective study describes 17 cases of onychomycosis diagnosed at the Laboratory of Parasitology and Mycology of Le Dantec University Hospital in Dakar, Senegal, from 2014 to 2016. Read More

    Risk Factors and Frequency of Ingrown Nails in Adult Diabetic Patients.
    J Foot Ankle Surg 2018 Mar - Apr;57(2):289-295. Epub 2018 Jan 10.
    Professor, Department of Neurology, Faculty of Medicine, Ankara University, Ankara, Turkey.
    The present study evaluated the properties of nails, frequency of ingrown nails in patients with type 2 diabetes mellitus (DM), risk factors for developing ingrown nails, and effect of diabetic polyneuropathy and vasculopathy on the development and outcome of ingrown nails. Our 6-month epidemiologic prospective study included 300 patients with type 2 DM attending a DM outpatient clinic for routine examinations. The general characteristics and foot changes of the study population were investigated. Read More

    Terbinafine hydrochloride nail lacquer for the management of onychomycosis: formulation, characterization and in vitro evaluation.
    Ther Deliv 2018 Feb;9(2):99-119
    Department of Pharmaceutical Sciences, Pharmaceutics Division, Punjabi University, Patiala, 147002, India.
    Aim: The present investigation's intention was to develop an optimized nail lacquer (NL) for the management of onychomycosis.

    Materials & Methods: The NL was optimized statistically adopting 3 full factorial design having different polymer ratios and solvent ratios. The formulations were assessed for drug permeation drying time and peak adhesive strength of the film. Read More

    Nail changes in alopecia areata: an update and review.
    Int J Dermatol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
    Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer-reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms "nail changes alopecia areata," "alopecia areata nails," and specific searches on "trachyonychia alopecia areata" and "pitting alopecia areata. Read More

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