730 results match your criteria Onycholysis


Untargeted Metabolomics Profiling Identifies Onycholysis-Specific Signature in Psoriasis.

Joint Bone Spine 2022 May 13:105410. Epub 2022 May 13.

Service de Biochimie et Biologie moléculaire, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France; Laboratoire CarMeN, INSERM U1060, INRAE U1397, Université de Lyon, Université Claude Bernard Lyon1, 69600, Oullins, France.

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Docetaxel induced hemorrhagic onycholysis.

Dermatol Ther 2022 May 10:e15578. Epub 2022 May 10.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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Successful Treatment of Nail Lichen Planus with a Lacquer Containing Urea, Keratinase, and a Retinoid Molecule: Report of 10 Cases.

Case Rep Dermatol 2022 Jan-Apr;14(1):43-48. Epub 2022 Mar 21.

Outpatient Podiatry Medicine Clinic, Alcamo, Italy.

Lichen planus is chronic inflammatory mucocutaneous disease. Involvement of nails (nail lichen planus: NLP) could be the only manifestation or it could be associated with the other typical skin and mucous localizations. Typical NLP alterations are linear nail bed dyschromia, longitudinal ridging, splitting, onycholysis, and subungual hyperkeratosis. Read More

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The impact of psoriasis on the clinical characteristics, disease burden and treatment patterns of peripheral spondyloarthritis.

Rheumatology (Oxford) 2022 Apr 22. Epub 2022 Apr 22.

Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin.

Objectives: To evaluate the clinical characteristics, disease burden, and treatment patterns of peripheral spondyloarthritis (pSpA) patients with and without psoriasis using data from the ASAS-perSpA study.

Methods: We included 433 patients who had a diagnosis of pSpA according to the rheumatologist's diagnosis from the ASAS-PerSpA study. The presence of a personal history of psoriasis was defined as the presence of signs of psoriasis at physical examination or the presence of psoriatic nail dystrophy, including onycholysis, pitting, and hyperkeratosis, or a history of psoriasis diagnosed by a physician. Read More

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[Translated article] Nail Psoriasis.

Actas Dermosifiliogr 2022 Apr 15. Epub 2022 Apr 15.

Departamento de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Nail involvement in psoriasis is common. It is seen in up to 80% of patients with psoriatic lesions and may be the only manifestation in 6% of cases. Nail psoriasis is correlated with more severe disease, characterized by earlier onset and a higher risk of psoriatic arthritis. Read More

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Nails Involvement in Winiwarter-Buerger Disease.

Skin Appendage Disord 2022 Mar 21;8(2):142-145. Epub 2021 Sep 21.

Department of Specialized, Experimental and Diagnostic Medicine, Dermatology-IRCCS, Policlinico Sant'Orsola, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Introduction: Buerger disease, or thromboangiitis obliterans, is an inflammatory and occlusive process involving small and medium size arteries and veins, which generally affects the lower limbs of young adult male with the habit of smoking.

Case Presentation: This paper reports 2 patients who developed nail lesions as the first sign of Buerger disease.

Conclusion: Signs and symptoms of Buerger's disease are secondary to the inflammatory process and arterial occlusion which results in severe ischemia. Read More

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Onycholysis associated with Kawasaki disease: A comment on "Characteristic nail lesions in Kawasaki disease: Case series and literature review".

J Dermatol 2022 Mar 20. Epub 2022 Mar 20.

Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

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Onychomycosis: Recommendations for Diagnosis, Assessment of Treatment Efficacy, and Specialist Referral. The CONSONANCE Consensus Project.

Dermatol Ther (Heidelb) 2022 Apr 9;12(4):885-898. Epub 2022 Mar 9.

Department of Dermatology-Venereology, Faculty of Medicine, National and Kapodistrian University of Athens-Andreas Sygros Hospital, Athens, Greece.

Introduction: Onychomycosis is the most common nail disorder in adults, with high recurrence and relapse rates. Its diagnosis may be difficult by non-experts because the clinical signs may overlap with other dermatoses. The treatment may be challenging, as it should be patient-tailored. Read More

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Neoscytalidium dimidiatum as onychomycosis causative agent in an Iranian patient: a case report and literature review.

New Microbes New Infect 2022 Jan 10;45:100952. Epub 2022 Jan 10.

Islamic Azad University, Tehran Medical Branch, Iran.

A 38-year-old healthy male presented to our medical mycology center with whitish opaque discoloration of the right toenail. He reported a history of some sand scratches subsequent to walking barefoot on the beach two years ago and wearing hard safety shoes for a period of two years. On clinical examination, onycholysis, onychodystrophy, and apparent thickening of the ungual bed in the left big toe were found. Read More

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January 2022

Optimal diagnosis and management of common nail disorders.

Ann Med 2022 12;54(1):694-712

Department of Dermatology, Weill Cornell Medicine New York, NY, USA.

Nail conditions are not only aesthetic concerns, and nail changes may be a clue to an underlying systemic diseases or infection. Without timely treatment, nail diseases can continue to worsen and significantly impair performance of daily activities and reduce quality of life. Examination of the nails is essential at every medical visit, and may uncover important findings. Read More

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December 2022

Fungal Infections and Nail Psoriasis: An Update.

J Fungi (Basel) 2022 Feb 3;8(2). Epub 2022 Feb 3.

2nd Department of Dermatology and Venereology, Medical School, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece.

The relationship between psoriasis and onychomycosis is controversial, and the exact nature of this association remains to be clearly elucidated. In healthy nails, the compact nail plate acts as a barrier, preventing any infection. In psoriatic nails, the nail plate involvement, together with abnormalities in the blood capillaries, may lead to decreased natural defenses against microorganisms. Read More

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February 2022

Unequal relevance between different subtypes of fingernail psoriasis and psoriatic arthritis.

Clin Rheumatol 2022 Feb 19. Epub 2022 Feb 19.

Department of Rheumatology and Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Nail disease in psoriasis has been found to be associated with psoriatic arthritis (PsA); however, which subtype of nail disease holds greater relevance to PsA remains unclear. This study was performed to explore the associations between three subtypes of fingernail disease (pitting, onycholysis, and hyperkeratosis) and PsA among patients with psoriasis. Patients with psoriasis attending five dermatology clinics in Shanghai between January 2020 and May 2021 were examined for skin, joint, and fingernail changes. Read More

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February 2022

Severe Acute Systemic Reaction After the First Injections of Ixekizumab.

Cutis 2022 Jan;109(1):E33-E35

Dr. Pappas is from the Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania. Dr. Liaqat is from Kaiser Permanente Medical Group, Santa Clara, California. Dr. Halpern is from the University of Pennsylvania, Philadelphia.

We report the case of a 39-year-old woman who presented with generalized malaise; lymphadenopathy; arthritis; dactylitis; ecchymosis; acute onycholysis; and a red, nonpruritic, nonscaly, mottled rash on the right breast 24 hours after the first injections of ixekizumab for psoriasis and psoriatic arthritis. Ixekizumab is a humanized IgG4 monoclonal antibody that binds to IL-17A. Adverse events of ixeki-zumab include infection, inflammatory bowel disease, candidiasis and tinea infections, severe injection-site reactions, arthralgia, headache, infections, neutropenia, and thrombocytopenia. Read More

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January 2022

The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials.

BMC Cancer 2022 Jan 25;22(1):104. Epub 2022 Jan 25.

Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Background: Administration of single-agent docetaxel in a weekly schedule may offer similar efficacy, with a more favorable toxicity profile, compared to a three-weekly schedule in patients with metastatic breast cancer.

Methods: The original search of Medline, Embase, and Scopus was performed in September 2018 and references were updated with additional searches up to January 2021. Two reviewers independently screened the identified literature based on a predefined set of criteria. Read More

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January 2022

The role of dermoscopy in the diagnosis of subungual glomus tumors.

Int J Dermatol 2022 Jan 24. Epub 2022 Jan 24.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background And Objectives: The dermoscopic features of glomus tumors have only been described in a few case reports. The aim of this research was to define the clinical and dermoscopic features of subungual glomus tumors.

Methods: Thirty-two patients with subungual glomus tumors were evaluated retrospectively. Read More

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January 2022

Modeling Occupational Fingernail Onycholysis Disorders in the Population of US Astronauts Who Have Engaged in Extravehicular Activity.

Hum Factors 2021 Dec 27:187208211062299. Epub 2021 Dec 27.

43834NASA Johnson Space Center, Houston, TX, USA.

Objectives: Spacesuits are designed to be reliable personal spacecraft that preserve the life and well-being of the astronaut from the extremes of space. However, materials, operating pressures, and suit design requirements often result in a risk of musculoskeletal discomfort and injury to various areas of the body. In particular, this investigation looked at fingernails and their risk of developing onycholysis. Read More

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December 2021

Overall Prevalence and Prevalence Compared among Psoriasis Treatments of Onychomycosis in Patients with Nail Psoriasis and Fungal Involvement.

Biomed Res Int 2021 13;2021:9113418. Epub 2021 Dec 13.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Whether nail psoriasis can increase the risk of onychomycosis is still being debated, and data relating to the prevalence of onychomycosis among psoriasis patients receiving different treatments is limited.

Objectives: To investigate the overall prevalence and prevalence compared among psoriasis treatments of onychomycosis in patients with nail psoriasis and fungal involvement.

Methods: A prospective study of three groups of nail psoriasis being treated with only topical medication, methotrexate, or biologics (25 patients per group, 150 nails) was conducted at Siriraj Hospital (Bangkok, Thailand) during November 2018 to September 2020. Read More

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January 2022

Efinaconazole in Onychomycosis.

Am J Clin Dermatol 2022 Mar 13;23(2):207-218. Epub 2021 Dec 13.

Mediprobe Research Inc., 645 Windermere Road, London, ON, N5X 2P1, Canada.

Onychomycosis is a fungal nail infection that causes nail discoloration, nail plate thickening, and onycholysis. Efinaconazole 10% topical solution is an FDA-approved treatment for onychomycosis patients aged 6 years and above. The drug functions as an antifungal by disrupting ergosterol synthesis in the fungal cell membrane. Read More

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A Subungual Exostosis Mimicking a Periungual Granuloma in a 9-Year-Old Boy: An Unexpected Dermoscopic Pattern.

Skin Appendage Disord 2021 Nov 9;7(6):483-485. Epub 2021 Jul 9.

Section of Dermatology, Department of Clinical Medicine and Surgery, University Hospital Federico II of Naples, Napoli, Italy.

Subungual exostosis (SE) is an uncommon osteocartilaginous tumor. Classic dermoscopic features of SE include vascular ectasia, hyperkeratosis, onycholysis, and ulceration. In this case, a 9-year-old boy presented SE showing a dermoscopic mesh dilated blood vessel pattern surrounded by a scar-like peripheral ring, which represents a novel finding in the medical literature. Read More

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November 2021

First Subungual Cryptococcosis Described in an HIV Patient with Disseminated Cryptococcosis.

Skin Appendage Disord 2021 Nov 23;7(6):480-482. Epub 2021 Jun 23.

Department of Dermatology and Venerology, Ibn Rochd University Hospital, Casablanca, Morocco.

Background: Cutaneous cryptococcosis occurs in 10-15% of patients with disseminated cryptococcosis. It typically presents as papulonodular molluscum-like lesions, but it can also produce a wide variety of lesions. Cryptococcal infection of the nail unit has never been reported. Read More

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November 2021

Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy.

Case Rep Oncol 2021 Sep-Dec;14(3):1530-1535. Epub 2021 Oct 22.

Departement of Oncology, Centre Anti Cancer, Sidi Bel Abbès, Algeria.

Onychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. Read More

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October 2021

Pseudogynecomastia: A chance occurrence with acitretin.

Indian J Pharmacol 2021 Sep-Oct;53(5):388-390

Department of Dermatology, Dr. RMLH, ABVIMS, New Delhi, India.

Psoriatic involvement of nails manifests in the form of irregular, deep and large pits, splinter hemorrhages, subungual hyperkeratosis, oil drop spot, and onycholysis of the nail bed. Retinoids are one of the treatment modalities for nail psoriasis. Pseudogynecomastia is an uncommonly reported side effect of retinoids. Read More

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February 2022

Hereditary Distal Onycholysis: A New Affected Family.

Indian J Dermatol 2021 Jul-Aug;66(4):424-425

Deparment of Dermatology, Valme University Hospital, Seville, Spain E-mail:

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November 2021

Taxane-induced scleroderma. Report of two cases.

Rev Med Chil 2021 May;149(5):807-809

Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.

Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents. Read More

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Nails with bloodstained discoloration.

BMJ 2021 10 13;375:n1951. Epub 2021 Oct 13.

National and Kapodistrian University of Athens; Andreas Sygros Hospital, 16121 Athens, Greece.

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October 2021

Case of de novo nail psoriasis triggered by the second dose of Pfizer-BioNTech BNT162b2 COVID-19 messenger RNA vaccine.

JAAD Case Rep 2021 Nov 22;17:18-20. Epub 2021 Sep 22.

Department of Dermatology, Weill Cornell Medicine, New York, New York.

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November 2021

Application of Topical Lidocaine for Pain Relief in the Setting of Targeted Therapy-Induced Onycholysis: A Case Report.

J Palliat Med 2022 02 22;25(2):335-336. Epub 2021 Sep 22.

Department of Pharmacy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Selective pan fibroblast growth factor receptor (FGFR) inhibitors have been linked to severe onycholysis, the uncomfortable separation of the nail plate from the nail bed. Recommendations to assist with FGFR inhibitor onycholysis vary based on the severity. We hypothesized that the application of topical lidocaine to mimic a digital nerve block would be beneficial in addition to traditional supportive care interventions and subsequently report its immediate and continued efficacy for targeted therapy-induced onycholysis. Read More

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February 2022

Disappearing Nail Bed: Review of Etiology, Grading System, and Treatment Options.

Clin Podiatr Med Surg 2021 Oct;38(4):521-527

Temple University School of Podiatric Medicine, 148 North 8th Street, Philadelphia, PA 19107, USA. Electronic address:

Disappearing nail bed (DNB) is a condition characterized by irreversible epithelialization of the nail bed following long-standing onycholysis. This phenomenon can occur in fingernails and toenails. Factors implicated in the development of DNB include trauma, manicuring, and onychotillomania and dermatologic conditions like psoriasis and dermatitis. Read More

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October 2021

Dermoscopic Evaluation of Inflammatory Nail Disorders and Their Mimics.

Acta Derm Venereol 2021 Sep 15;101(9):adv00548. Epub 2021 Sep 15.

Alfred Health, Melbourne, Australia.

Nail dermoscopy (onychoscopy) is a valuable diagnostic tool for evaluating diseases in the nail apparatus. It is non-invasive, allowing clinicians to prioritize particular nails for biopsy. Thus, it can improve diagnostic accuracy and expedite treatment. Read More

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September 2021