J Clin Oncol 2012 Feb;30(5_suppl):67

CH Privé Saint Grégoire, Saint Gregoire, France; Oncologie Hematologie Radiotherapie, Saint Gregoire, France; CH Mignot, Le Chesnay, France; Université Rennes 1, GRETAC, Rennes, France.

67 Background: Polyamines (PA) are essential for cancer cell growth. Reducing exogenous PA (foods + gut flora) and blocking PA synthesis, reduces tumour growth and potentializes chemotherapy in rodent tumour models. We have developed a PA "free" ONS, which inhibits tumour growth by 40% in pre-clinical models and assessed its tolerance with docetaxel in CRPC pts. Read More

Turk Pediatri Ars 2017 Jun 1;52(2):98-100. Epub 2017 Jun 1.

Division of Pediatric Neurology, Bezmialem Vakif University School of Medicine, İstanbul, Turkey.

Valproic acid is an effective, frequently used anticonvulsant drug. Typical adverse effects include weight gain, hair loss, and nausea. Hyperpigmentation, onycholysis, and onychomadesis are nail changes that can be seen after valproic acid use. Read More

J Am Acad Dermatol 2017 Jun 27. Epub 2017 Jun 27.

Department of Dermatology, St. Luke's International University, Tokyo, Japan.

Background: Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations.

Objective: This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without arthritis.

Methods: We performed a retrospective analysis of 118 patients with PsA and 974 patients with psoriasis without arthritis who visited St. Read More

Indian J Dermatol Venereol Leprol 2017 Jun 28. Epub 2017 Jun 28.

Department of Microbiology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India.

Background: Nail involvement in psoriasis is common with a lifetime incidence of 80-90%. It may reflect severity of cutaneous involvement and predict joint disease. Yet it remains, poorly studied and evaluated especially in Indian psoriatic patients. Read More

Arch Bone Jt Surg 2017 May;5(3):193-195

Department of Orthopedics, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.

Koebner phenomenon is observed in a number of inflammatory skin diseases. Psoriasis is one of the most common skin diseases associated with Koebner phenomenon. Nail psoriasis may be developed independently from inflammatory arthritis and skin psoriasis. Read More

Turk J Med Sci 2017 Jun 12;47(3):764-770. Epub 2017 Jun 12.

Department of Dermatology, İstanbul Medeniyet University, Göztepe Research and Training Hospital, İstanbul, Turkey.

Background/aim: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.

Materials And Methods: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study. Read More

Skin Appendage Disord 2017 Mar 6;3(1):15-17. Epub 2017 Jan 6.

Private Practice Dermatology Clinic, Jackson, MS, USA.

Background: The nail bed may epithelialize and develop dermatoglyphics after long-standing onycholysis. We have called this phenomenon the disappearing nail bed (DNB). DNB may present as a shortened or narrow nail bed. Read More

Skin Res Technol 2017 Jun 5. Epub 2017 Jun 5.

Institute for Diagnostic Imaging Research, University of Windsor, Windsor, ON, Canada.

Background: Medical practitioners have long associated the physical appearance of human fingernails with certain underlying health conditions due to their direct connection to the vascular system. The objective of this study was to demonstrate how human fingernails can potentially be used as a biomarker to determine the severity of a patient's reaction to chemotherapy.

Methods: Quantitative investigation of fingernails in patients undergoing taxane-based chemotherapy was conducted using a high-frequency 50 MHz ultrasound device in B-mode in the form of a pilot study. Read More

Skin Appendage Disord 2017 May 8;3(2):70-82. Epub 2017 Mar 8.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while gel as an interface is necessary for assessment of nail pigmentation and onycholysis, as well as for the evaluation of the distal nail margin. Read More

JAMA Dermatol 2017 Jul;153(7):723-725

Departments of Oncodermatology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.

Breast Cancer Res Treat 2017 Aug 9;164(3):617-625. Epub 2017 May 9.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.

Purpose: Onycholysis and other nail toxicities occur in approximately 20-30% of breast cancer (BC) patients receiving docetaxel chemotherapy. Onycholysis is often associated with painful paronychia, decreasing patients' quality of life. In this study, we aimed to evaluate the efficacy of hydrating nail solution (HNS) (EVONAIL(®) solution, Evaux Laboratories, France) for the prevention and treatment of docetaxel-induced onycholysis and nail toxicities. Read More

Dermatology 2017 9;233(1):80-85. Epub 2017 May 9.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Introduction: Subungual exostosis (SE), the most common nail tumor of young adults, is a benign bony proliferation of the distal phalanx occurring beneath the nail. Misdiagnosis or late diagnosis frequently occurs and no dermoscopy features of this tumor were previously outlined.

Material And Methods: To describe the dermoscopic appearance of SE, 10 patients with radiologically and histologically confirmed SE were retrospectively retrieved from our tertiary referral centers. Read More

J Fam Pract 2017 May;66(5):E7-E9

The Reading Hospital and Medical Center, PA, USA.

The patient hadn't injured her thumb and it didn't hurt. So why had her nail turned green? Read More

Reumatologia 2017 22;55(1):44-47. Epub 2017 Mar 22.

Chair and Department of Hygiene, Medical University of Lublin, Poland.

Psoriasis is a chronic recurrent inflammatory skin disease with prevalence of 1-3%. Nail psoriasis affects 10-90% of patients with plaque psoriasis. The aim of the article is to review the literature for the correlation between nail psoriasis and psoriatic arthritis (PsA) to provide rheumatologists a short review on features of nail psoriasis, methods of their assessment and possible clinical repercussions. Read More

Case Rep Dermatol Med 2017 23;2017:3613109. Epub 2017 Feb 23.

Department of Pathology, Hospital Universitario Severo Ochoa, Avenida de Orellana, Leganés, 28911 Madrid, Spain.

Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. The histopathology shows a pattern of acantholytic dyskeratosis. We report a 32-year-old man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first toe 2 years ago. Read More

Skin Pharmacol Physiol 2017 15;30(2):76-80. Epub 2017 Mar 15.

Department of Dermatology, University Hospital Jena, Jena, Germany.

Background: One of the most important dermatologic side effects of doxycycline is photosensitivity. As doxycycline is important for malaria prophylaxis and malaria is mainly spread in countries with high sun radiation, special attention should be paid to this adverse effect. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist focusing on doxycycline. Read More

Postepy Dermatol Alergol 2017 Feb 7;34(1):28-35. Epub 2017 Feb 7.

Department of Dermatology, Ankara Numune Research and Education Hospital, Ankara, Turkey.

Introduction: Dermoscopy is a non-invasive imaging method that enables the evaluation of pigmented and non-pigmented skin lesions. More recently, dermoscopy has been recognized as an effective tool in the diagnosis of nail diseases.

Aim: To evaluate the dermoscopic features of nail psoriasis and to assess the relationship between these features and disease severity. Read More

Skin Appendage Disord 2017 Jan 11;2(3-4):137-142. Epub 2016 Oct 11.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, Institute of Macromolecular Chemistry Petru Poni, Iasi, Romania.

Background: Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) techniques have been used in various fields of medical research, including different pathologies of the nails; however, no studies have focused on obtaining high-resolution microscopic images and elemental analysis of disorders caused by synthetic nails and acrylic adhesives.

Methods: Damaged/injured fingernails caused by the use of acrylate glue and synthetic nails were investigated using SEM and EDX methods.

Results: SEM and EDX proved that synthetic nails, acrylic glue, and nails damaged by contact with acrylate glue have a different morphology and different composition compared to healthy human nails. Read More

Cutis 2017 Jan;99(1):E8-E11

Icahn School of Medicine at Mount Sinai, New York, New York, and the University of Southern California, Los Angeles, USA.

Actas Dermosifiliogr 2017 Jul - Aug;108(6):595-597. Epub 2017 Jan 20.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Case Rep Dermatol Med 2016 22;2016:7137691. Epub 2016 Dec 22.

Karmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USA.

Background. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. Read More

Int J Dermatol 2017 Mar 13;56(3):e61-e62. Epub 2017 Jan 13.

Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.

Photomed Laser Surg 2017 Apr 30;35(4):213-216. Epub 2016 Dec 30.

5 Department of Health Sciences, University of Catanzaro , Catanzaro, Italy .

Objective: The aim of this study is to evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser in penetrating tissue and targeting the fungal overgrowth in the nail plate.

Background: Onychomycosis is the most frequent nail disorder. Current treatments include oral and topical antifungal agents, photodynamic therapy, and surgical approaches such as mechanical, chemical, or surgical nail avulsion. Read More

Mediators Inflamm 2016 7;2016:7617954. Epub 2016 Dec 7.

Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.

Objectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). Patients and Methods. Read More

J Mycol Med 2017 Mar 29;27(1):119-123. Epub 2016 Dec 29.

Laboratoire de parasitologie-mycologie, hôpital militaire Moulay Ismaïl, boulevard Mohamed, El Hansali, Meknès 50000, Maroc.

Introduction: Trichophyton tonsurans is an anthropophilic dermatophyte, frequent in the USA and in Asia where it is responsible for causing tinea capitis. At present, we attend an emergence of this species in certain regions where it was not or little met. Here, we report a case of onychomycosis of the hand due to T. Read More

Pediatr Dermatol 2017 Jan 22;34(1):58-63. Epub 2016 Nov 22.

Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.

Background/objectives: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis.

Methods: We performed a multicenter, cross-sectional study in 23 French dermatology centers. Read More

Occup Med (Lond) 2016 Dec 7;66(9):751-753. Epub 2016 Nov 7.

Dermatology Department, University Hospital of Guadalajara, Guadalajara 19002, Spain.

Acrylates are molecules that are well known for their strong sensitizing properties. Historically, many beauticians and individuals using store-bought artificial nail products have developed allergic contact dermatitis from acrylates. More recently, the use of acrylic nails among flamenco guitarists to strengthen their nails has become very popular. Read More

G Ital Dermatol Venereol 2016 Dec;151(6):706-709

Department of Medical and Surgical Physiopathology, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy -

The authors describe a case of onychomycosis by Paecilomyces lilacinus in an 81-year-old Caucasian woman. The infection was characterized clinically by yellow-brown discoloration of the nail plate, distal-lateral onycholysis and subungual hyperkeratosis of the first left toenail. Microscopic examination showed irregular hyphae. Read More

Foot Ankle Surg 2016 Dec 27;22(4):229-232. Epub 2015 Oct 27.

Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India. Electronic address:

Background: The study aimed at finding whether there are any nail changes specific to treatment in clubfoot.

Methods: Sixty new, 26 undergoing serial corrective casting, and 247 clubfoot patients using foot abduction braces were prospectively studied. The casted and braced group formed the basis of the study to observe nail changes, if any. Read More

Int J Dermatol 2017 Feb 3;56(2):e28-e29. Epub 2016 Nov 3.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

J Eur Acad Dermatol Venereol 2017 Feb 20;31(2):371-375. Epub 2016 Oct 20.

University François Rabelais Tours, Tours, France.

Introduction: The anatomy and embryology of the nail are well known, and nail abnormalities are a feature of many genodermatoses. However, the physiological aspect is not well described. We aimed to analyse the physiological features of nails in healthy newborns. Read More

Cutis 2016 Aug;98(2):E10-1

Central Dermatology Center, Chapel Hill, North Carolina, USA.

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

Dermatology department of Federal University of Pará, Brasil.

Nail involvement in Langerhans cell histiocytosis is uncommon and is said to indicate a poor prognosis. We describe a 2-year-old boy with onycholysis, subungual hyperkeratosis, and hemorrhages on his fingernails. He also had hepatosplenomegaly and pulmonary involvement. Read More

An Bras Dermatol 2016 Jul-Aug;91(4):442-5

Department of Biochemistry, Adana Public Health Laboratory-Adana, Turkey.

Background: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. Read More

Neth J Med 2016 Jul;74(6):273

Neth J Med 2016 Jul;74(6):272

Department of Internal Medicine, Division of Tropical Diseases, Academic Medical Centre, Amsterdam, the Netherlands.

J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):21-8

Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.

Psoriasis is a common chronic inflammatory dermatosis that causes significant distress and morbidity. Approximately 50% of patients with cutaneous psoriasis and 90% of patients with psoriatic arthritis demonstrate nail involvement of their psoriasis. Left untreated, nail psoriasis may progress to debilitating nail disease that leads to not only impairment of function but also on quality of life. Read More

An Bras Dermatol 2016 May-Jun;91(3):300-5

Hospital Naval Marcilio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.

Background: Psoriasis is a chronic inflammatory skin disease that often progresses with nail alterations. It is suspected that there is a correlation between nail psoriasis and enthesitis of the distal interphalangeal joint, seeming to serve as a predictor.

Objectives: To analyze the profile of patients with nail psoriasis and correlate the presence of nail alterations with psoriatic arthritis, quality of life, extent of psoriasis and the histopathology of the nail. Read More

J Nepal Health Res Counc 2016 Jan;14(32):66-8

Department of Dermatology, Dhulikhel Hospital Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.

Photo-onycholysis is a form of phototoxic reaction characterized by spontaneous separation of the nail plate from the nail bed. It usually follows drug intake and tetracycline is a well-known culprit. We present a case of 19 years gentleman who developed this rare side effect following two weeks of ingestion of doxycycline. Read More

Rev Peru Med Exp Salud Publica 2016 Mar;33(1):162-7

A 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Read More

Clin Rheumatol 2016 Aug 1;35(8):2031-2037. Epub 2016 Jun 1.

Rheumatology Unit, Department of Medicine and Geriatrics, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong.

Psoriatic nail disease and distal interphalangeal (DIP) arthritis both are common manifestations of psoriatic arthritis (PsA). Several clinical characteristics are allegedly associated with DIP joint damage, particularly nail psoriasis. However, there is little evidence to substantiate this phenomenon. Read More

J Eur Acad Dermatol Venereol 2016 Aug 26;30(8):1278-84. Epub 2016 May 26.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Psoriatic involvement of the nail is notoriously refractory to conventional therapy. Nail psoriasis has a high incidence amongst patients with psoriasis. It remains a significant cosmetic problem and thus, has a significant impact on quality of life. Read More

Skin Appendage Disord 2016 Feb 24;1(3):144-6. Epub 2015 Nov 24.

Mycology Section, Department of Dermatology, 'Dr. Manuel Gea Gonzalez' General Hospital, Mexico City, Mexico.

Yeasts cause only 5-10% of onychomycosis; the most common yeast is Candida albicans, and rarely Trichosporon spp. is found. Recently, it has become an important cause of fungemia with a high mortality rate in immunocompromised patients. Read More

Skin Appendage Disord 2015 Sep 18;1(2):91-4. Epub 2015 Jul 18.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Fla., USA.

Acrylic nails, including sculptured nails and the new ultraviolet-curable gel polish lacquers, have been associated with allergic contact dermatitis (ACD). We report 2 cases of ACD to acrylic nails with severe onychodystrophy and psoriasiform changes including onycholysis and subungual hyperkeratosis. In both cases, the patients did not realize the association between the use of acrylate-based manicures and nail changes. Read More

Skin Appendage Disord 2015 Sep 3;1(2):82-6. Epub 2015 Jul 3.

Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, USA.

Background: Cutaneous T-cell lymphoma (CTCL) encompasses a broad range of lymphoproliferative diseases affecting the skin and can be clinically misleading due to its variable presentation. Nail alterations commonly appear in advanced-stage mycosis fungoides and true Sézary syndrome; however, they may be present in any stage of the disease. Although proper recognition of nail involvement in CTCL has both clinical and therapeutic value, specific nail findings have been infrequently described in the current literature. Read More

Chest 2016 May;149(5):e147-50

Division of Pulmonary/Critical Care Medicine, Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York, NY.

An 80-year-old man presented because of superficial head trauma sustained after falling from bed. On review of systems, he reported worsening dyspnea on exertion, nonproductive cough, and weight loss over the preceding 2 to 3 months. There was no report of chest pain or leg swelling. Read More

Acta Dermatovenerol Croat 2016 Apr;24(1):70-2

Daška Štulhofer Buzina, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Read More

Eur J Dermatol 2016 Aug;26(4):377-81

Saint-André Hospital, University Hospital of Bordeaux, 1 rue Jean Burguet, 33000 Bordeaux, France.

Retronychia is a form of post-traumatic ingrowing nail disease that involves proximal nail plate embedding into the proximal nail fold, with multiple generations of nail plate beneath the proximal nail. This disease is probably underdiagnosed because of incomplete clinical forms. The aim of this study was to report clinical and aetiological variants of retronychia and to evaluate their therapeutic outcome. Read More

Int J Dermatol 2016 Oct 20;55(10):1172-5. Epub 2016 Apr 20.

Department of Obstetrics and Gynecology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.

During pregnancy, cutaneous and appendageal alterations manifest and may cause concern in the subject. The nails may be affected by pregnancy. This study investigated the frequency and nature of nail changes occurring during pregnancy in 312 healthy, 18-40-year-old pregnant women in gestation weeks 16-40. Read More

Aust Fam Physician 2016 Mar;45(3):120-1