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J Cutan Pathol 2021 May 2. Epub 2021 May 2.

Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, IL.

Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia (PPE), is a localized cutaneous adverse event (CAE) associated with a variety of chemotherapeutic agents, such as doxorubicin, fluorouracil, cytarabine, and docetaxel. HFS is characterized by painful erythema, edema, and desquamation of the skin, most prominently involving the hands and soles of the feet. However, HFS primarily affecting the dorsal hands and feet (also called periarticular thenar erythema and onycholysis or PATEO) is known to occur as a class-based effect with the taxane chemotherapeutic drug class. Read More

Ann Dermatol 2020 Apr 11;32(2):146-150. Epub 2020 Mar 11.

Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.

Solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm that usually arises in the pleura, but also has been reported in numerous extrapleural locations, including cutaneous site. The skin lesion presents as a circumscribed nodule or tumor, mainly on the head and neck. A 41-year-old male presented with 6 months history of nail lesion without symptom on the left third finger. Read More

J Dermatol 2021 Apr 24. Epub 2021 Apr 24.

Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Dermoscopy is an efficient and non-invasive technique which has been widely used in the diagnosis of nail disorders including nail psoriasis (NP). Many nail dermoscopic features are considered as clues to NP. The aim of this study was to investigate specific dermoscopic features of fingernail psoriasis and the correlation between the severity of nail lesions or systemic inflammation, and psoriasis severity of skin and nail. Read More

J Am Podiatr Med Assoc 2021 Mar;111(2)

Background: It is well established and accepted that fungi are a major contributing factor in nail dystrophy. It has also been recognized that bacteria play a crucial role in onycholysis. However, the bacteria and fungi that can be grown on culture media in the laboratory are only a small fraction of the total diversity that exists in nature. Read More

Dermatol Clin 2021 Apr 10;39(2):293-304. Epub 2021 Feb 10.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 1, Bologna 40138, Italy.

Nail dermoscopy (onychoscopy) is being used for a more accurate diagnosis of all nail disorders and has become a routine diagnostic instrument. In daily practice, nail signs can be magnified, and dermoscopy may confirm the clinical diagnosis and guides in management of nail diseases and treatments, permitting a better visualization of symptoms. Onychoscopy is used by the experts in almost all nail diseases. Read More

Dermatol Clin 2021 Apr 11;39(2):183-193. Epub 2021 Feb 11.

Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, New York, NY 10021, USA. Electronic address:

Nail involvement is common in patients with cutaneous psoriasis, which is prevalent among older adults. Nail psoriasis greatly impacts patients' quality of life and self-esteem. Concomitant psoriatic arthritis is common. Read More

J Clin Aesthet Dermatol 2020 Dec 1;13(12):18-20. Epub 2020 Dec 1.

Dr. Adigun is with the Dermatology & Laser Center of Chapel Hill in Chapel Hill, North Carolina.

Multiple cases have reported onychodystrophy secondary to acrylic nails. We present a case of onychodystrophy with psoriasiform nail changes, including onycholysis, splinter hemorrhages, hyperkeratosis, and nail plate thinning, caused by gel manicures. Histopathological analysis of the nail plate and subungual debris revealed neutrophils in the absence of fungal elements. Read More

Am J Ophthalmol Case Rep 2021 Mar 31;21:101007. Epub 2020 Dec 31.

University of Puerto Rico, Medical Sciences Campus, School of Medicine, Department of Ophthalmology, San Juan, PR, USA.

Purpose: To report an atypical bilateral hypopyon presentation of syphilitic uveitis.

Observations: A 38-year-old male presented with a 2-day history of bilateral progressive visual loss, conjunctival hyperemia, and photophobia. Initial ophthalmologic examination revealed bilateral hypopyon and vitritis that limited the examination of the posterior segment. Read More

Cureus 2020 Nov 20;12(11):e11597. Epub 2020 Nov 20.

Dermatology, San Diego Family Dermatology, National City, USA.

Methyl ethyl ketone is an organic solvent commonly used in adhesives and paints. Overexposure to methyl ethyl ketone can irritate the central nervous system, eyes, and respiratory system. When in direct contact with skin, methyl ethyl ketone can lead to dryness and cracking of the skin. Read More

Indian Dermatol Online J 2020 Nov-Dec;11(6):970-974. Epub 2020 Sep 19.

Department of Social and Preventive Medicine, Government Medical College, Kozhikode, Kerala, India.

Context: Repeated trauma involving extremities (in the setting of peripheral neuropathy) and poor vascularity that impairs wound healing are important causes of disability and deformity in leprosy patients. Nail changes can serve as indicators of trophic changes due to leprosy.

Aims: To describe the onychoscopy findings in leprosy cases and to identify any specific findings in leprosy patients in comparison to controls. Read More

J Cutan Med Surg 2020 Dec 18:1203475420982554. Epub 2020 Dec 18.

49726 Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Rzeszów, Poland.

Background: Lichen planus (LP) is an inflammatory condition that can affect skin, mucous membranes, hair follicles, and/or nails. Nail abnormalities are estimated to occur in around 10% of LP cases. Clinical characteristics of nail involvement have been the subject of very few studies, which have mainly focused on isolated nail LP. Read More

Int J Dermatol 2021 Jun 17;60(6):693-702. Epub 2020 Dec 17.

Faculty of Dermatology, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia.

Background: Subungual glomus tumor is a relatively uncommon entity with varied clinical presentations which may lead to diagnostic delays. Onychoscopy can be used as an evaluation tool in routine evaluation of glomus tumors.

Objectives And Methods: With an aim to characterize the onychoscopic features of subungual glomus tumors, we analyzed 15 cases presenting over 3 years, in this observational study. Read More

J Dermatol 2021 Mar 11;48(3):360-365. Epub 2020 Dec 11.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Pathogenesis of palmoplantar pustulosis (PPP) is not fully understood and whether PPP is a variant of plaque psoriasis (PsO) is still controversial. Psoriatic nail changes are among the clinical features common to both diseases, and understanding them could lead to the understanding of the correlation between both diseases. However, only limited numbers of studies have reported nail involvement pattern in PPP. Read More

Contact Dermatitis 2021 Jun 8;84(6):449-450. Epub 2020 Dec 8.

Department of Dermatology, University Hospital Antwerp (UZA), Antwerp, Belgium.

Indian Dermatol Online J 2020 Sep-Oct;11(5):777-783. Epub 2020 Sep 19.

Layers Skin and Hair Clinic, Hyderabad, Telangana, India.

Background: Clinical differentiation of onycholysis due to various etiologies is difficult task that compels to do invasive investigations to arrive at accurate diagnosis. Wrong diagnosis often leads to treatment failure and physicians and patient's anxiety. Dermoscopic patterns in nail psoriasis, onychomycosis are well established. Read More

J Cosmet Dermatol 2020 Nov 11. Epub 2020 Nov 11.

Department of Dermatology, Koru Hospital, Ankara, Turkey.

Background: Toenail dystrophies are among the most common diseases in adulthood. Onychomycosis is one of the most frequently observed infectious diseases of the nail.

Aim: The aim of this study was to determine the prevalence of fungal agents in the etiology of nail dystrophies such as discoloration, thickening, subungual hyperkeratosis, and onycholysis in toenails and to emphasize the importance of diagnosis by other laboratory confirmation tests since various nail diseases may mimic onychomycosis. Read More

Oncologist 2021 02 28;26(2):e316-e326. Epub 2020 Oct 28.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Fibroblast growth factor receptor (FGFR) tyrosine kinases, which are expressed on the cell membrane, are involved in a wide range of biological functions such as cell proliferation, survival, migration, and differentiation. The identification of FGFR fusions and other alterations in a wide range of solid tumors, including cholangiocarcinoma and bladder cancer, has resulted in the development of several selective FGFR inhibitors for use in these indications, for example, infigratinib, erdafitinib, derazantinib, pemigatinib, and futibatinib. In addition to the typical adverse events associated with tyrosine kinases, the FGFR inhibitors appear to give rise to a number of adverse events affecting the skin. Read More

Skin Appendage Disord 2020 Jul 11;6(4):207-215. Epub 2020 Jun 11.

Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.

Introduction: Nail involvement in psoriasis occurs in up to 30-50% of patients, and 5-10% may have isolated nail disease. Onychoscopy, a noninvasive tool, might obviate the need for nail biopsy, which is a diagnostic gold standard.

Objective: The aim of this study was to evaluate onychoscopic features of nail unit in patients with nail psoriasis. Read More

Rheumatology (Oxford) 2021 Mar;60(3):1176-1184

Université Claude Bernard Lyon I, Lyon, France.

Objectives: PsA prevalence among skin psoriasis is ∼30%. Nail psoriasis, especially onycholysis, is present in >70% of PsA and the risk of developing PsA is more than doubled in patients with nail involvement. We hypothesized that onycholysis may be associated with early bone erosions of the DIP joint without harbouring PsA symptoms. Read More

Postepy Dermatol Alergol 2020 Jun 16;37(3):396-400. Epub 2020 Jul 16.

Department of Dermatology and Venereology, Faculty of Medicine, Ahi Evran University, Kırşehir, Turkey.

Introduction: There are very few studies investigating the dermoscopic aspect of nail involvement in lichen planus and these studies described dermoscopic features of only clinically visible nail involvement in lichen planus.

Aim: To reveal subtle dermoscopic nail findings in patients with lichen planus.

Material And Methods: The study included 40 patients with lichen planus and 40 healthy volunteers. Read More

J Cosmet Dermatol 2021 May 11;20(5):1418-1420. Epub 2020 Aug 11.

Dr. Hakan Erbil Private Clinic, Ankara, Turkey.

Nail psoriasis is challenging; as topical agents generally fail and systemic therapies are doubted especially when the involvement of the skin is rather localized. The response of chronic plaque-type psoriasis to botulinum toxin injections is reported in case series that is essentially explained through the modulation of neurogenic inflammation. Herein, we report the successful treatment results of two cases demonstrating different features of nail psoriasis treated by abobotulinum toxin. Read More

Ann Dermatol Venereol 2020 Dec 3;147(12):823-832. Epub 2020 Aug 3.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:

Introduction: There are few studies focusing on ungual lesions in patients with lupus erythematosus (LE). The aim of this study is to describe our experience with ungual lesions in LE patients.

Materials And Methods: A multicentric retrospective descriptive study was performed at the dermatology departments of the university hospitals in Strasbourg and at the Tenon hospital in Paris and involved reviewing the medical records and photographs of patients with ungual lesions. Read More

Curr Opin Pediatr 2020 08;32(4):506-515

Department of Dermatology, Hospital of the University of Pennsylvania.

Purpose Of Review: Nail disorders represent an uncommon subset of complaints seen in pediatric dermatology. There is a wide array of disorders that can affect the nail unit in children, including infectious, inflammatory, neoplastic, congenital, and traumatic processes. In order to enhance familiarity with pediatric nail conditions, we review the background and treatment of the more common entities seen in pediatric onychology, including onychomycosis, onychomadesis, nail psoriasis, trachyonychia, longitudinal melanonychia, onychophagia, and onychocryptosis. Read More

Actas Dermosifiliogr 2020 Nov 11;111(9):783. Epub 2020 Jul 11.

Servicio de Dermatología, Hospital de la Sant Creu i Sant Pau, Barcelona, España.

Indian J Dermatol 2020 May-Jun;65(3):193-198

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Introduction: Nail toxicity is a relatively uncommon cutaneous adverse effect of chemotherapeutic agents. Rapidly dividing cells of the nail matrix are perturbed by the antimitotic activity of these agents. Although most of these changes are cosmetic and regress once the therapy is completed, a few of these adverse effects are challenging to manage and require temporary or permanent suspension of chemotherapeutic agents. Read More

Mycoses 2020 Sep 4;63(9):964-969. Epub 2020 Jul 4.

Department of Dermatology, Sheba Medical Center, Ramat-Gan, Israel.

Background: Candida onychomycosis mostly involves fingernails. Yet, in contrast to dermatophytes, Candida isolation from dystrophic fingernails does not prove casualty, as sample contamination and non-pathogenic Candida growth occur. Characterising treatment outcome of Candida-positive dystrophic nails is crucial to avoid unnecessary treatment. Read More

JAAD Case Rep 2020 Jun 25;6(6):569-571. Epub 2020 Apr 25.

Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Dtsch Arztebl Int 2020 Mar;117(12):196

J Dermatol 2020 Jun 27;47(6):e230-e232. Epub 2020 Mar 27.

Division of Dermatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand.