J Drugs Dermatol 2018 Apr;17(4):475-478

Proximal subungual onychomycosis (PSO), which predominantly involves the nail plate from the proximal nail fold, is the rarest form of onychomycosis. Classically associated with an immunocompromised state, PSO is an uncommon diagnosis in individuals without immunodeficiency. We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Read More

Clin Case Rep 2018 Mar 26;6(3):543-544. Epub 2018 Jan 26.

Department of Thoracic OncologyNational Hospital Organization Toneyama National HospitalToyonakaOsaka560-8552Japan.

The symptoms of infection can be minimal or absent in patients with febrile neutropenia at first. The focal site of infection, which may be the main cause of a fever or be a complication of neutropenia, can develop as neutrophils increase during the clinical course of febrile neutropenia. Read More

Clin Case Rep 2018 Feb 22;6(2):267-268. Epub 2017 Dec 22.

Department of DermatologyAddenbrookes HospitalCambridgeUK.

Melanin in the nail bed in patients with skin type VI has been suggested to afford some protection against photo-onycholysis. We report a case of a 16-year-old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid. Read More

Indian Dermatol Online J 2018 Jan-Feb;9(1):16-19

Department of Dermatology, Yenepoya Medical College, Yenepoya University, Mangaluru, Karnataka, India.

Background: Onychomycosis is a very common disease and accounts for upto 50% of the diseases affecting the nail apparatus. Diagnosis of onychomycosis is usually confirmed with the help of a potassium hydroxide (KOH) mount and fungal culture. Onychoscopy can be a handy and additional tool for the diagnosis. Read More

J Coll Physicians Surg Pak 2018 Feb;28(2):98-102

Statistician, Government MAO College, Lahore.

Objective: To determine skin changes in patients of End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) and factors affecting these changes.

Study Design: Cross-sectional observational study.

Place And Duration Of Study: Nephrology Department, Mayo Hospital, Lahore in collaboration with Dermatology Department, King Edward Medical University, Lahore, from October 2015 to January 2016. Read More

Psoriasis (Auckl) 2017 16;7:51-63. Epub 2017 Oct 16.

Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.

Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. Read More

Int J Dermatol 2018 Jan 10. Epub 2018 Jan 10.

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer-reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms "nail changes alopecia areata," "alopecia areata nails," and specific searches on "trachyonychia alopecia areata" and "pitting alopecia areata. Read More

Acta Oncol 2017 Dec 28:1-2. Epub 2017 Dec 28.

c Division of Dermatology, Department of Medicine , Albert Einstein College of Medicine , New York , NY , USA.

Transl Pediatr 2017 Oct;6(4):300-312

The Ohio State University College of Medicine, Columbus, OH, USA.

The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

J Am Podiatr Med Assoc 2017 Sep;107(5):413-418

Background: Onychomycosis is one of the most common diseases of the toenails. The costs of diagnosis and treatment are substantial, and as the population ages, the overall cost burden will continue to escalate. The purpose of this study was to correlate dermoscopic features with pathologic diagnosis to support the accuracy of point-of-care diagnosis by dermoscopic examination. Read More

J Clin Diagn Res 2017 Aug 1;11(8):WD01-WD03. Epub 2017 Aug 1.

Assistant Professor, Department of Pathology, Shaheed Hasan Khan Mewati, GMC, Nalhar, Rajasthan, India.

Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of older age group i. Read More

Drug Des Devel Ther 2017 14;11:2373-2376. Epub 2017 Aug 14.

Department of Dermatology, Qianfoshan Hospital, Shandong University, Jinan, People's Republic of China.

The side effects of chemotherapy drugs have increased in recent years, and some side effects can lead to onychomadesis. A 72-year-old woman who was diagnosed with an invasive ductal carcinoma of the right breast underwent a modified radical mastectomy in April 2015, followed by chemotherapy with capecitabine and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Subsequently, the patient experienced palmoplantar redness, pain, onycholysis, a transparent serous exudate, and onychomadesis. Read More

Skinmed 2017 1;15(4):315-317. Epub 2017 Aug 1.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.

A 34-year-old man from Djibouti presented with a 14-year history of relapsing and remitting transverse white bands on the fingernails with sparing of the toenails. Examination revealed several transverse, white bands following the contour of the lunula on seven of his fingernails that did not fade upon compression of the digits (Figure). There was no onycholysis. Read More

Turk Pediatri Ars 2017 Jun 1;52(2):98-100. Epub 2017 Jun 1.

Division of Pediatric Neurology, Bezmialem Vakif University School of Medicine, İstanbul, Turkey.

Valproic acid is an effective, frequently used anticonvulsant drug. Typical adverse effects include weight gain, hair loss, and nausea. Hyperpigmentation, onycholysis, and onychomadesis are nail changes that can be seen after valproic acid use. Read More

J Am Acad Dermatol 2017 Nov 27;77(5):863-867. Epub 2017 Jun 27.

Department of Dermatology, St. Luke's International University, Tokyo, Japan.

Background: Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations.

Objective: This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without arthritis.

Methods: We performed a retrospective analysis of 118 patients with PsA and 974 patients with psoriasis without arthritis who visited St. Read More

Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):650-655

Department of Microbiology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India.

Background: Nail involvement in psoriasis is common with a lifetime incidence of 80-90%. It may reflect severity of cutaneous involvement and predict joint disease. Yet it remains, poorly studied and evaluated especially in Indian psoriatic patients. Read More

Arch Bone Jt Surg 2017 May;5(3):193-195

Department of Orthopedics, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.

Koebner phenomenon is observed in a number of inflammatory skin diseases. Psoriasis is one of the most common skin diseases associated with Koebner phenomenon. Nail psoriasis may be developed independently from inflammatory arthritis and skin psoriasis. Read More

Turk J Med Sci 2017 Jun 12;47(3):764-770. Epub 2017 Jun 12.

Department of Dermatology, İstanbul Medeniyet University, Göztepe Research and Training Hospital, İstanbul, Turkey.

Background/aim: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.

Materials And Methods: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study. Read More

Skin Appendage Disord 2017 Mar 6;3(1):15-17. Epub 2017 Jan 6.

Private Practice Dermatology Clinic, Jackson, MS, USA.

Background: The nail bed may epithelialize and develop dermatoglyphics after long-standing onycholysis. We have called this phenomenon the disappearing nail bed (DNB). DNB may present as a shortened or narrow nail bed. Read More

Skin Res Technol 2018 Feb 5;24(1):20-25. Epub 2017 Jun 5.

Institute for Diagnostic Imaging Research, University of Windsor, Windsor, ON, Canada.

Background: Medical practitioners have long associated the physical appearance of human fingernails with certain underlying health conditions due to their direct connection to the vascular system. The objective of this study was to demonstrate how human fingernails can potentially be used as a biomarker to determine the severity of a patient's reaction to chemotherapy.

Methods: Quantitative investigation of fingernails in patients undergoing taxane-based chemotherapy was conducted using a high-frequency 50 MHz ultrasound device in B-mode in the form of a pilot study. Read More

Skin Appendage Disord 2017 May 8;3(2):70-82. Epub 2017 Mar 8.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while gel as an interface is necessary for assessment of nail pigmentation and onycholysis, as well as for the evaluation of the distal nail margin. Read More

Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.

Department of Dermatology, Hôpital Nord, University of Amiens, Amiens, France.

Worn-down nail syndrome is a nail disorder characterized by thinning of the distal nail plate induced by repetitive mechanical trauma. A French variant, entitled "bidet nail syndrome" was first described by Baran. Read More

JAMA Dermatol 2017 Jul;153(7):723-725

Departments of Oncodermatology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.

Breast Cancer Res Treat 2017 Aug 9;164(3):617-625. Epub 2017 May 9.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.

Purpose: Onycholysis and other nail toxicities occur in approximately 20-30% of breast cancer (BC) patients receiving docetaxel chemotherapy. Onycholysis is often associated with painful paronychia, decreasing patients' quality of life. In this study, we aimed to evaluate the efficacy of hydrating nail solution (HNS) (EVONAIL solution, Evaux Laboratories, France) for the prevention and treatment of docetaxel-induced onycholysis and nail toxicities. Read More

Dermatology 2017 9;233(1):80-85. Epub 2017 May 9.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Introduction: Subungual exostosis (SE), the most common nail tumor of young adults, is a benign bony proliferation of the distal phalanx occurring beneath the nail. Misdiagnosis or late diagnosis frequently occurs and no dermoscopy features of this tumor were previously outlined.

Material And Methods: To describe the dermoscopic appearance of SE, 10 patients with radiologically and histologically confirmed SE were retrospectively retrieved from our tertiary referral centers. Read More

J Fam Pract 2017 May;66(5):E7-E9

The Reading Hospital and Medical Center, PA, USA.

The patient hadn't injured her thumb and it didn't hurt. So why had her nail turned green? Read More

Reumatologia 2017 22;55(1):44-47. Epub 2017 Mar 22.

Chair and Department of Hygiene, Medical University of Lublin, Poland.

Psoriasis is a chronic recurrent inflammatory skin disease with prevalence of 1-3%. Nail psoriasis affects 10-90% of patients with plaque psoriasis. The aim of the article is to review the literature for the correlation between nail psoriasis and psoriatic arthritis (PsA) to provide rheumatologists a short review on features of nail psoriasis, methods of their assessment and possible clinical repercussions. Read More

Case Rep Dermatol Med 2017 23;2017:3613109. Epub 2017 Feb 23.

Department of Pathology, Hospital Universitario Severo Ochoa, Avenida de Orellana, Leganés, 28911 Madrid, Spain.

Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. The histopathology shows a pattern of acantholytic dyskeratosis. We report a 32-year-old man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first toe 2 years ago. Read More

Skin Pharmacol Physiol 2017 15;30(2):76-80. Epub 2017 Mar 15.

Department of Dermatology, University Hospital Jena, Jena, Germany.

Background: One of the most important dermatologic side effects of doxycycline is photosensitivity. As doxycycline is important for malaria prophylaxis and malaria is mainly spread in countries with high sun radiation, special attention should be paid to this adverse effect. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist focusing on doxycycline. Read More

Postepy Dermatol Alergol 2017 Feb 7;34(1):28-35. Epub 2017 Feb 7.

Department of Dermatology, Ankara Numune Research and Education Hospital, Ankara, Turkey.

Introduction: Dermoscopy is a non-invasive imaging method that enables the evaluation of pigmented and non-pigmented skin lesions. More recently, dermoscopy has been recognized as an effective tool in the diagnosis of nail diseases.

Aim: To evaluate the dermoscopic features of nail psoriasis and to assess the relationship between these features and disease severity. Read More

Skin Appendage Disord 2017 Jan 11;2(3-4):137-142. Epub 2016 Oct 11.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, Institute of Macromolecular Chemistry Petru Poni, Iasi, Romania.

Background: Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) techniques have been used in various fields of medical research, including different pathologies of the nails; however, no studies have focused on obtaining high-resolution microscopic images and elemental analysis of disorders caused by synthetic nails and acrylic adhesives.

Methods: Damaged/injured fingernails caused by the use of acrylate glue and synthetic nails were investigated using SEM and EDX methods.

Results: SEM and EDX proved that synthetic nails, acrylic glue, and nails damaged by contact with acrylate glue have a different morphology and different composition compared to healthy human nails. Read More

Cutis 2017 Jan;99(1):E8-E11

Icahn School of Medicine at Mount Sinai, New York, New York, and the University of Southern California, Los Angeles, USA.

Actas Dermosifiliogr 2017 Jul - Aug;108(6):595-597. Epub 2017 Jan 20.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Case Rep Dermatol Med 2016 22;2016:7137691. Epub 2016 Dec 22.

Karmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USA.

. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. Read More

Int J Dermatol 2017 Mar 13;56(3):e61-e62. Epub 2017 Jan 13.

Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.

Photomed Laser Surg 2017 Apr 30;35(4):213-216. Epub 2016 Dec 30.

5 Department of Health Sciences, University of Catanzaro , Catanzaro, Italy .

Objective: The aim of this study is to evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser in penetrating tissue and targeting the fungal overgrowth in the nail plate.

Background: Onychomycosis is the most frequent nail disorder. Current treatments include oral and topical antifungal agents, photodynamic therapy, and surgical approaches such as mechanical, chemical, or surgical nail avulsion. Read More

Mediators Inflamm 2016 7;2016:7617954. Epub 2016 Dec 7.

Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.

In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. Read More

J Mycol Med 2017 Mar 29;27(1):119-123. Epub 2016 Dec 29.

Laboratoire de parasitologie-mycologie, hôpital militaire Moulay Ismaïl, boulevard Mohamed, El Hansali, Meknès 50000, Maroc.

Introduction: Trichophyton tonsurans is an anthropophilic dermatophyte, frequent in the USA and in Asia where it is responsible for causing tinea capitis. At present, we attend an emergence of this species in certain regions where it was not or little met. Here, we report a case of onychomycosis of the hand due to T. Read More

Pediatr Dermatol 2017 Jan 22;34(1):58-63. Epub 2016 Nov 22.

Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.

Background/objectives: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis.

Methods: We performed a multicenter, cross-sectional study in 23 French dermatology centers. Read More

Occup Med (Lond) 2016 Dec 7;66(9):751-753. Epub 2016 Nov 7.

Dermatology Department, University Hospital of Guadalajara, Guadalajara 19002, Spain.

Acrylates are molecules that are well known for their strong sensitizing properties. Historically, many beauticians and individuals using store-bought artificial nail products have developed allergic contact dermatitis from acrylates. More recently, the use of acrylic nails among flamenco guitarists to strengthen their nails has become very popular. Read More

G Ital Dermatol Venereol 2016 Dec;151(6):706-709

Department of Medical and Surgical Physiopathology, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy -

The authors describe a case of onychomycosis by Paecilomyces lilacinus in an 81-year-old Caucasian woman. The infection was characterized clinically by yellow-brown discoloration of the nail plate, distal-lateral onycholysis and subungual hyperkeratosis of the first left toenail. Microscopic examination showed irregular hyphae. Read More

Foot Ankle Surg 2016 Dec 27;22(4):229-232. Epub 2015 Oct 27.

Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India. Electronic address:

Background: The study aimed at finding whether there are any nail changes specific to treatment in clubfoot.

Methods: Sixty new, 26 undergoing serial corrective casting, and 247 clubfoot patients using foot abduction braces were prospectively studied. The casted and braced group formed the basis of the study to observe nail changes, if any. Read More

Int J Dermatol 2017 Feb 3;56(2):e28-e29. Epub 2016 Nov 3.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

J Eur Acad Dermatol Venereol 2017 Feb 20;31(2):371-375. Epub 2016 Oct 20.

University François Rabelais Tours, Tours, France.

Introduction: The anatomy and embryology of the nail are well known, and nail abnormalities are a feature of many genodermatoses. However, the physiological aspect is not well described. We aimed to analyse the physiological features of nails in healthy newborns. Read More

Cutis 2016 Aug;98(2):E10-1

Central Dermatology Center, Chapel Hill, North Carolina, USA.

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

Dermatology department of Federal University of Pará, Brasil.

Nail involvement in Langerhans cell histiocytosis is uncommon and is said to indicate a poor prognosis. We describe a 2-year-old boy with onycholysis, subungual hyperkeratosis, and hemorrhages on his fingernails. He also had hepatosplenomegaly and pulmonary involvement. Read More

An Bras Dermatol 2016 Jul-Aug;91(4):442-5

Department of Biochemistry, Adana Public Health Laboratory-Adana, Turkey.

Background: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. Read More

Neth J Med 2016 07;74(6):273

Neth J Med 2016 Jul;74(6):272

Department of Internal Medicine, Division of Tropical Diseases, Academic Medical Centre, Amsterdam, the Netherlands.

J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):21-8

Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.

Psoriasis is a common chronic inflammatory dermatosis that causes significant distress and morbidity. Approximately 50% of patients with cutaneous psoriasis and 90% of patients with psoriatic arthritis demonstrate nail involvement of their psoriasis. Left untreated, nail psoriasis may progress to debilitating nail disease that leads to not only impairment of function but also on quality of life. Read More