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Dermatol Ther 2019 Apr 9:e12914. Epub 2019 Apr 9.

Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.

Nail involvement can place a significant burden on patients as a result of functional damage and psychosocial problems, leading to major repercussions on the quality of life. There is strong evidence that nail psoriasis can often be difficult to treat. We report a a 69 year-old-man with severe onychodystrophy, onycholysis, and pain in the hands; he had been previously treated with topical and systemic traditional therapies without satisfactory response. Read More

Br J Dermatol 2019 Apr;180(4):e102

Department of Dermatology, South Infirmary Victoria University Hospital, Cork, Ireland.

J Cutan Med Surg 2019 Mar 27:1203475419839937. Epub 2019 Mar 27.

1 Cutaneous Lymphoma Program, Department of Dermatology, University of Pittsburgh Medical Center, PA, USA.

Background:: The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications.

Objectives:: The objectives of this study were to identify and describe the most frequent nail alterations in patients with SzS. Read More

J Eur Acad Dermatol Venereol 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology, Saint-Pierre, Brugmann and Queen Fabiola Children's University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

Background: Very few studies have been conducted to establish the nature and prevalence of nail disorders in children.

Objectives: To determine the frequency of various nail conditions in the paediatric setting and to report their management and follow-up.

Methods: This was a retrospective study between 2007 and 2017 of children under 18. Read More

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the Royal National Hospital for Rheumatic Diseases, Bath, UK; Department of Mathematics, University of Bath, Bath, UK; Department of Dermatology, Royal United Hospital, Bath, UK; Department of Mathematics, University of Exeter, Exeter, UK; Department of Radiology, Royal United Hospital, Bath, UK; Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK; Department of Rheumatology, Concord Repatriation General Hospital, Sydney, Australia; Department of Pharmacy and Pharmacology, University of Bath, UK8; Department of Medicine, University of Cambridge, Cambridge, UK. Address correspondence to Dr. William Tillett Email:

Objective: To assess if the association between psoriatic nail dystrophy and radiographic damage in the hands of patients with psoriatic arthritis (PsA) is specific to the distal interphalangeal joints.

Methods: A convenience sample of patients were collated from the Bath longitudinal PsA cohort. All patients had PsA according to the CASPAR criteria, scored radiographs of their hands, and documented nail scores as measured by the Psoriatic Nail Severity Score (PNSS). Read More

J Clin Rheumatol 2019 Feb 19. Epub 2019 Feb 19.

From the Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Clin Exp Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Dermatology Department, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.

Nail cosmetics are used by millions worldwide and the variety of products available is expanding. They are relatively safe, but complications can occur, and patients experiencing complications may present to dermatologists. The physical processes can cause nail thinning and onycholysis, poor technique can promote infection, and consumers may develop allergic contact dermatitis. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):118-119

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Clin Exp Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, China.

Background: Identification of onychomycosis is mainly based on clinical diagnosis with auxiliary diagnostic methods such as potassium hydroxide (KOH) microscopy, periodic acid-Schiff staining or fungal culture. However, each method is limited by its sensitivity and specificity.

Aim: To develop a new test method using the common fungal end product, ergosterol, and investigate if it can be used as a new diagnostic tool. Read More

J Eur Acad Dermatol Venereol 2019 Apr;33(4):648-660

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Dermoscopy is a non-invasive in-office method, which enables the diagnosis of many dermatoses and reduces the need for performing biopsies. To date, no systematic review about the diagnostic usability of dermoscopy in psoriasis has been available. The objective of this article was to summarize and critically analyse literature data on the dermoscopy of skin, scalp and nail changes in psoriasis. Read More

Skin Appendage Disord 2018 Oct 13;4(4):315-319. Epub 2018 Feb 13.

Department of Oncodermatology, Claudius Regaud Institute, Cancer University Institute, Toulouse Oncopole, Toulouse, France.

We have observed three patients on anticancer therapies presenting with asymmetric acral spared phenomenon and found six identical cases in the literature. All of them had common features, an alteration of the peripheral nerves affecting a limb unilaterally that was spared by a hand-foot syndrome or hand-foot skin reaction. A drug-induced neurotropic effect sounds logical for developing such alterations with specific chemotherapeutic agents (taxanes, cap-ecitabine), while we have not found good explanations concerning the multikinase inhibitor sorafenib nor the topo isomerase inhibitor adriamycin. Read More

Autoimmune Dis 2018 15;2018:4608490. Epub 2018 Oct 15.

Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Background: Psoriatic arthritis (PsA) results in an increased burden of psoriasis and impairs both quality of life and an individual's functional capacity. The relationship between nail involvement and PsA in psoriasis is not fully characterized.

Aim: To evaluate the frequency and characteristics of nail involvement in psoriatic patients and to assess the relationship with joint involvement. Read More

JAMA Dermatol 2018 Dec;154(12):1465-1472

The George Washington University School of Medicine and Health Sciences, Washington, DC.

Importance: Chemotherapy-induced alopecia as well as nail and cutaneous changes occur in up to 89% of patients receiving taxane-based chemotherapy and are associated with cosmetic concerns, psychosocial distress, and overall morbidity.

Objective: To review the efficacy and safety of interventions to prevent taxane-induced dermatologic adverse events.

Evidence Review: PubMed and Scopus databases were systematically reviewed for studies published in the English language from January 1, 1980, to August 13, 2018. Read More

Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39

Institut Universitaire du Cancer Toulouse - Oncopole, 1 avenue Irène Joliot-Curie, 31059, TOULOUSE Cedex 9, France.

Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. Read More

Biomed Res Int 2018 9;2018:8251097. Epub 2018 Sep 9.

Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.

Aim Of The Study: The aim of the study was to conduct an ultrasound (US) assessment of changes in fingernails in psoriatic patients with nail involvement.

Material: A total of 69 patients with psoriatic changes in nails participated in the study, including 38 patients with psoriasis (Ps) and 31 with psoriatic arthritis (PsA) and 30 people in the control group. A total of 988 nails were examined. Read More

Indian Dermatol Online J 2018 Sep-Oct;9(5):314-317

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Nail involvement in psoriasis is often complicated by concomitant fungal infections. The aim of this study was to investigate the prevalence of fungal infections in nail psoriasis and correlate it with the severity of nail psoriasis.

Materials And Methods: This retrospective study included patients with nail psoriasis aged ≥18 years with at least one fingernail and one toenail involvement who were treated at Siriraj Hospital from September 2012 to January 2014. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2018 Sep;27(3):149-151

Gauhati Medical College and Hospital, Guwahati, Assam, India.

Sparfloxacin is an antibiotic in the quinolone group of antibacterial agents, which often induce photosensitive skin reactions, more often phototoxic reactions than photoallergic ones, and sometimes associated photo-onycholysis. We present a case of phototoxic dermatitis with photo-onycholysis in a 38-year-old man probably induced by sparfloxacin, which was prescribed to him along with rifampicin and clofazimine because he was suffering from borderline lepromatous leprosy. He developed exaggerated sunburn-like eruptions mainly on sun-exposed sites along with painful onycholysis of the fingernails. Read More

Top Companion Anim Med 2018 Sep 12;33(3):73-76. Epub 2018 Jun 12.

School of Veterinary Medicine and Animal Science, Department of Veterinary Clinic, São Paulo State University-UNESP, Botucatu, SP, Brazil. Electronic address:

A 12-year-old Rottweiler dog was presented with a history of prostration, weight loss and hyporexia for six months. Based on complete blood tests (hematological and biochemical analyses), bone marrow examination and imaging analysis, a diagnosis of chronic myeloid leukemia was made. Treatment with hydroxyurea at a dosage of 18 mg/kg twice daily was not effective in controlling the high count of white blood cells. Read More

Int J Dermatol 2019 Apr 19;58(4):425-427. Epub 2018 Sep 19.

Dermatology Division, Children's National Medical Center, Washington, DC, USA.

Dermatol Clin 2018 Oct;36(4):431-438

Department of Specialised Experimental and Diagnostic Medicine, Dermatology, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.

Onychoscopy is the examination of the nail unit using a dermoscope. The dermoscopic criteria for a valid diagnosis have been developed and assessed in numerous papers. However, in all nail alterations that are suspicious or potentially malignant, a surgical intervention with subsequent histopathological evaluation should be performed. Read More

An Bras Dermatol 2018 Sep-Oct;93(5):707-711

Dermatology Department, Hospital do Servidor Público Municipal de São Paulo, São Paulo (SP), Brazil.

Retronychia is a recently described disorder caused by ingrowth of the proximal nail plate into the proximal nail fold. It is suspected when there is persistent paronychia, particularly in the setting of trauma. This disease is probably underdiagnosed due to limited knowledge among dermatologists and the presence of incomplete clinical forms. Read More

Front Med (Lausanne) 2018 14;5:227. Epub 2018 Aug 14.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris. Sixty seven ethnic Poles suffering from pemphigus vulgaris on photographic files archiving initial presentation were retrospectively evaluated. Read More

Dermatol Pract Concept 2018 Jul 31;8(3):238-244. Epub 2018 Jul 31.

Department of Specialized, Diagnostic and Experimental Medicine, University of Bologna, Bologna, Italy.

Squamous cell carcinoma (SCC) of the nail apparatus is a rare malignant tumor that usually originates underneath the nail plate and grows slowly with possible bone invasion. The etiology remains unknown, although a strong association with different conditions, such as high-risk human papillomavirus (HPVs), trauma, or radiation exposure has been demonstrated. Nail SCC is called "the great mimicker nail tumor" because different clinical presentations may coexist, resembling benign or malignant nail lesions. Read More

Bull Cancer 2018 Dec 2;105(12):1173-1182. Epub 2018 Aug 2.

AP-HP, hôpital Cochin Port-Royal, service de cancérologie, 123, boulevard Port-Royal, 75014 Paris, France.

Background: Docetaxel is frequently used for the treatment of metastatic prostate cancer patients. Nail toxicity is a commonly described side effect, but no precise recommendation exists concerning its management. We experimented the integration of a podiatrist in routine cancer care. Read More

J Cutan Pathol 2018 Nov 30;45(11):824-830. Epub 2018 Aug 30.

Department of Dermatology & STD, University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi, India.

Background: Nail psoriasis can pose diagnostic difficulties as there are several close clinical mimickers, including onychomycosis, lichen planus, and even squamous cell carcinoma. In view of differing treatment and prognostic implications, it is important to make an accurate diagnosis, especially in cases with isolated nail involvement.

Methods: Sixty consecutive patients with nail changes suggestive of psoriasis were included. Read More

Intern Med 2018 Oct 18;57(20):3055-3056. Epub 2018 May 18.

Department of Internal Medicine, Jisenkai Aizawa Hospital, Japan.

Breast Cancer Res Treat 2018 Aug 7;171(1):103-110. Epub 2018 May 7.

Bedford and Addenbrooke's Cambridge University Hospital Trusts c/o The Primrose Unit, Kempston Rd, Bedford, MK42 9DJ, UK.

Purpose: Nail damage is common amongst patients receiving chemotherapy causing disfigurement and pain. This investigation evaluated whether a topical balm containing steam-extracted, bioactive polyphenolic-rich herbal oils blended with organic waxes could protect the nails via their reported anti-inflammatory, analgesic, anti-oxidant and anti-microbial properties.

Methods: 60 patients (23M, 37F) were randomised to apply (2-3/day) either the plant balm (PB) or a petroleum control (PC) to their nail beds. Read More

J Drugs Dermatol 2018 Apr;17(4):475-478

Proximal subungual onychomycosis (PSO), which predominantly involves the nail plate from the proximal nail fold, is the rarest form of onychomycosis. Classically associated with an immunocompromised state, PSO is an uncommon diagnosis in individuals without immunodeficiency. We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Read More

Clin Case Rep 2018 03 26;6(3):543-544. Epub 2018 Jan 26.

Department of Thoracic Oncology National Hospital Organization Toneyama National Hospital Toyonaka Osaka 560-8552 Japan.

The symptoms of infection can be minimal or absent in patients with febrile neutropenia at first. The focal site of infection, which may be the main cause of a fever or be a complication of neutropenia, can develop as neutrophils increase during the clinical course of febrile neutropenia. Read More

Clin Case Rep 2018 02 22;6(2):267-268. Epub 2017 Dec 22.

Department of Dermatology Addenbrookes Hospital Cambridge UK.

Melanin in the nail bed in patients with skin type VI has been suggested to afford some protection against photo-onycholysis. We report a case of a 16-year-old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid. Read More

Indian Dermatol Online J 2018 Jan-Feb;9(1):16-19

Department of Dermatology, Yenepoya Medical College, Yenepoya University, Mangaluru, Karnataka, India.

Background: Onychomycosis is a very common disease and accounts for upto 50% of the diseases affecting the nail apparatus. Diagnosis of onychomycosis is usually confirmed with the help of a potassium hydroxide (KOH) mount and fungal culture. Onychoscopy can be a handy and additional tool for the diagnosis. Read More

J Coll Physicians Surg Pak 2018 Feb;28(2):98-102

Statistician, Government MAO College, Lahore.

Objective: To determine skin changes in patients of End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) and factors affecting these changes.

Study Design: Cross-sectional observational study.

Place And Duration Of Study: Nephrology Department, Mayo Hospital, Lahore in collaboration with Dermatology Department, King Edward Medical University, Lahore, from October 2015 to January 2016. Read More

Psoriasis (Auckl) 2017 16;7:51-63. Epub 2017 Oct 16.

Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.

Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. Read More

Int J Dermatol 2018 Jul 10;57(7):776-783. Epub 2018 Jan 10.

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer-reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms "nail changes alopecia areata," "alopecia areata nails," and specific searches on "trachyonychia alopecia areata" and "pitting alopecia areata. Read More

Acta Oncol 2018 07 28;57(7):991-992. Epub 2017 Dec 28.

c Division of Dermatology, Department of Medicine , Albert Einstein College of Medicine , New York , NY , USA.

Transl Pediatr 2017 Oct;6(4):300-312

The Ohio State University College of Medicine, Columbus, OH, USA.

The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

J Am Podiatr Med Assoc 2017 Sep;107(5):413-418

Background: Onychomycosis is one of the most common diseases of the toenails. The costs of diagnosis and treatment are substantial, and as the population ages, the overall cost burden will continue to escalate. The purpose of this study was to correlate dermoscopic features with pathologic diagnosis to support the accuracy of point-of-care diagnosis by dermoscopic examination. Read More

J Clin Diagn Res 2017 Aug 1;11(8):WD01-WD03. Epub 2017 Aug 1.

Assistant Professor, Department of Pathology, Shaheed Hasan Khan Mewati, GMC, Nalhar, Rajasthan, India.

Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of older age group i. Read More

Drug Des Devel Ther 2017 14;11:2373-2376. Epub 2017 Aug 14.

Department of Dermatology, Qianfoshan Hospital, Shandong University, Jinan, People's Republic of China.

The side effects of chemotherapy drugs have increased in recent years, and some side effects can lead to onychomadesis. A 72-year-old woman who was diagnosed with an invasive ductal carcinoma of the right breast underwent a modified radical mastectomy in April 2015, followed by chemotherapy with capecitabine and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Subsequently, the patient experienced palmoplantar redness, pain, onycholysis, a transparent serous exudate, and onychomadesis. Read More

Skinmed 2017 1;15(4):315-317. Epub 2017 Aug 1.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.

A 34-year-old man from Djibouti presented with a 14-year history of relapsing and remitting transverse white bands on the fingernails with sparing of the toenails. Examination revealed several transverse, white bands following the contour of the lunula on seven of his fingernails that did not fade upon compression of the digits (Figure). There was no onycholysis. Read More

Indian J Dermatol Venereol Leprol 2018;84(2):244-246

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Turk Pediatri Ars 2017 Jun 1;52(2):98-100. Epub 2017 Jun 1.

Division of Pediatric Neurology, Bezmialem Vakif University School of Medicine, İstanbul, Turkey.

Valproic acid is an effective, frequently used anticonvulsant drug. Typical adverse effects include weight gain, hair loss, and nausea. Hyperpigmentation, onycholysis, and onychomadesis are nail changes that can be seen after valproic acid use. Read More

J Am Acad Dermatol 2017 Nov 27;77(5):863-867. Epub 2017 Jun 27.

Department of Dermatology, St. Luke's International University, Tokyo, Japan.

Background: Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations.

Objective: This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without arthritis.

Methods: We performed a retrospective analysis of 118 patients with PsA and 974 patients with psoriasis without arthritis who visited St. Read More

Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):650-655

Department of Microbiology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India.

Background: Nail involvement in psoriasis is common with a lifetime incidence of 80-90%. It may reflect severity of cutaneous involvement and predict joint disease. Yet it remains, poorly studied and evaluated especially in Indian psoriatic patients. Read More

Arch Bone Jt Surg 2017 May;5(3):193-195

Department of Orthopedics, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.

Koebner phenomenon is observed in a number of inflammatory skin diseases. Psoriasis is one of the most common skin diseases associated with Koebner phenomenon. Nail psoriasis may be developed independently from inflammatory arthritis and skin psoriasis. Read More

Turk J Med Sci 2017 Jun 12;47(3):764-770. Epub 2017 Jun 12.

Department of Dermatology, İstanbul Medeniyet University, Göztepe Research and Training Hospital, İstanbul, Turkey.

Background/aim: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.

Materials And Methods: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study. Read More

Skin Appendage Disord 2017 Mar 6;3(1):15-17. Epub 2017 Jan 6.

Private Practice Dermatology Clinic, Jackson, MS, USA.

Background: The nail bed may epithelialize and develop dermatoglyphics after long-standing onycholysis. We have called this phenomenon the disappearing nail bed (DNB). DNB may present as a shortened or narrow nail bed. Read More

Skin Res Technol 2018 Feb 5;24(1):20-25. Epub 2017 Jun 5.

Institute for Diagnostic Imaging Research, University of Windsor, Windsor, ON, Canada.

Background: Medical practitioners have long associated the physical appearance of human fingernails with certain underlying health conditions due to their direct connection to the vascular system. The objective of this study was to demonstrate how human fingernails can potentially be used as a biomarker to determine the severity of a patient's reaction to chemotherapy.

Methods: Quantitative investigation of fingernails in patients undergoing taxane-based chemotherapy was conducted using a high-frequency 50 MHz ultrasound device in B-mode in the form of a pilot study. Read More

Skin Appendage Disord 2017 May 8;3(2):70-82. Epub 2017 Mar 8.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while gel as an interface is necessary for assessment of nail pigmentation and onycholysis, as well as for the evaluation of the distal nail margin. Read More

Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.

Department of Dermatology, Hôpital Nord, University of Amiens, Amiens, France.

Worn-down nail syndrome is a nail disorder characterized by thinning of the distal nail plate induced by repetitive mechanical trauma. A French variant, entitled "bidet nail syndrome" was first described by Baran. Read More