2,330 results match your criteria Onkologie [Journal]


Successful treatment with nab-paclitaxel and gemcitabine after FOLFIRINOX failure in a patient with metastasized pancreatic adenocarcinoma.

Onkologie 2013 20;36(12):763-5. Epub 2013 Nov 20.

National Center for Tumor Diseases, University Medical Center Heidelberg, Heidelberg, Germany.

Background: Advanced pancreatic adenocarcinoma still remains associated with a desperate prognosis. Nevertheless, treatment options for patients with metastasized disease have improved considerably over the last few years. Recently, cytotoxic combination therapies such as the FOLFIRINOX regimen and combined nab-paclitaxel/gemcitabine have shown improved overall survival compared to gemcitabine alone. Read More

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http://dx.doi.org/10.1159/000356811DOI Listing
August 2014
12 Reads

Metastatic germ cell tumour following renal transplantation.

Onkologie 2013 20;36(12):760-2. Epub 2013 Nov 20.

Department of Medical Oncology, Cork University Hospital, Ireland.

Background: Treatment of germ cell tumours with cisplatin-based chemotherapy results in cure for the majority of patients. There is, however, a small but significant mortality rate, reported to be higher in patients with multiple co-morbidities.

Case Report: We report our management of a renal transplant patient with spina bifida, who was diagnosed with stage IIIC, poor-risk, non-seminomatous germ cell carcinoma. Read More

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http://dx.doi.org/10.1159/000356837DOI Listing
August 2014
6 Reads

miR-145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c-Myc.

Onkologie 2013 20;36(12):754-8. Epub 2013 Nov 20.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, P.R. China.

Background: Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal cancer and crucial to tumorigenesis. Herein, we identified the role of miR-145 in esophageal squamous cell carcinoma (ESCC) development in vitro and in vivo.

Material And Methods: miR-145 expression was investigated in 40 ESCC samples as well as 5 ESCC cell lines by real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1159/000356978DOI Listing
August 2014
3 Reads

A meta-analysis of internal mammary lymph node metastasis in breast cancer patients.

Onkologie 2013 20;36(12):747-52. Epub 2013 Nov 20.

Tangshan Gongren Hospital, Lunan District, Tangshan, China.

Background: Knowing the status of the internal mammary lymph (IML) nodes is important for accurate staging and appropriate selection of subsequent treatment in breast cancer. We conducted a meta-analysis to clarify the rate of IML node metastasis in breast cancer patients and discussed the importance of this finding.

Methods: We retrieved articles from the literature that reported positive rates of IML node metastasis in breast cancer patients. Read More

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http://dx.doi.org/10.1159/000356867DOI Listing
August 2014
31 Reads

Patient-related delay in presentation for cutaneous squamous cell carcinoma. A cross-sectional clinical study.

Onkologie 2013 20;36(12):738-44. Epub 2013 Nov 20.

First Department of Surgery, Democritus University of Thrace, Dragana, Alexandroupolis, Greece.

Background: Delayed diagnosis of squamous cell carcinoma (SCC) increases recurrence, metastatic potential, and management costs. This study aims to identify risk factors of patient-related delayed presentation in cutaneous SCC.

Patients And Methods: A total of 513 patients, who first sought care for cutaneous lesions that were subsequently removed and histologically confirmed as SCCs, were included. Read More

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http://dx.doi.org/10.1159/000356834DOI Listing
August 2014
7 Reads

Treatment of primary breast cancer at the surgical unit of the Charité 1984-1998.

Onkologie 2013 22;36(12):727-36. Epub 2013 Nov 22.

Brustzentrum Charité, Medizinische Klinik und Poliklinik, Universitätsmedizin Berlin, Germany.

Background: We have analyzed the patient population of one clinic (Charité) over a period of 15 years. Besides the changes in the technical facilities and therapeutical guidelines during these years, this period also reflects the changes in the health system attributable to the reunification of East and West Germany. Until now only few analyses for breast cancer patients from the German speaking area have been reported. Read More

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http://dx.doi.org/10.1159/000356805DOI Listing
August 2014
15 Reads

RAS, BRAF, and TP53 gene mutations in Taiwanese colorectal cancer patients.

Onkologie 2013 20;36(12):719-24. Epub 2013 Nov 20.

Epigenome Research Center, China Medical University Hospital, Taichung, Taiwan.

Background: Colorectal cancer (CRC) plays an important role in cancer mortality and morbidity. This study examined colorectal tissues for RAS, BRAF, and TP53 gene mutations to assess their value as indicators of outcomes of CRC therapy.

Material And Methods: DNA was extracted from tissues taken from 165 patients with CRC. Read More

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http://dx.doi.org/10.1159/000356814DOI Listing
August 2014
5 Reads

Evaluation of cardiotoxicity via speckle-tracking echocardiography in patients treated with anthracyclines.

Onkologie 2013 20;36(12):712-6. Epub 2013 Nov 20.

Department of Medical Oncology, Medical Faculty, Kocaeli University, Turkey.

Background: The aim of this study was to examine the cardiac effects of anthracycline therapy based on speckle-tracking echocardiography (STE) and to identify patients at risk for cardiotoxicity.

Patients And Methods: The study included 35 breast cancer (BC) and 15 lymphoma patients who were treated with anthracycline-based chemotherapy. Conventional echocardiography and STE were performed 1 month prior to and 1 month after chemotherapy. Read More

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http://dx.doi.org/10.1159/000356850DOI Listing
August 2014
9 Reads

Vemurafenib-induced pulmonary injury.

Onkologie 2013 14;36(11):685-6. Epub 2013 Oct 14.

Department of Dermatology, Klinikum Ludwigshafen, Skin Cancer Center Rheinpfalz, Germany.

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http://dx.doi.org/10.1159/000355643DOI Listing
June 2014
13 Reads

Pre-operative peritumoral edema and survival rate in glioblastoma multiforme.

Onkologie 2013 14;36(11):679-84. Epub 2013 Oct 14.

Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

The aim of this systematic review was to examine the relationship between pre-operative peritumoral edema and survival in patients with glioblastoma multiforme (GBM). We searched for studies involving patients with GBM who underwent pre-operative imaging (magnetic resonance imaging and/or computed tomography) in which the peritumoral edema was assessed as a prognostic factor for survival. 7 retrospective studies met the eligibility criteria and were included in the study. Read More

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http://dx.doi.org/10.1159/000355651DOI Listing
June 2014
2 Reads

Radiation recall dermatitis induced by pazopanib.

Onkologie 2013 14;36(11):674-6. Epub 2013 Oct 14.

Joint Austin-Ludwig Oncology Unit, Austin Health, Melbourne, Australia.

Background: Pazopanib is a multi-targeted tyrosine kinase inhibitor that has recently been approved for treatment of advanced clear cell renal cell carcinoma (RCC). There are no previous reports of pazopanib triggering radiation recall dermatitis (RRD).

Case Report: A 60-year-old male patient was commenced on pazopanib for metastatic RCC 2 weeks prior to receiving radiotherapy (10×30 Gy) to bone metastases at the T9 and L4 vertebrae and right mid-shaft of humerus. Read More

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http://dx.doi.org/10.1159/000355649DOI Listing
June 2014
27 Reads

Major efficacy of trabectedin in 2 metastatic osteosarcoma patients with wild-type Asp1104 ERCC5 tumor status.

Onkologie 2013 14;36(11):670-3. Epub 2013 Oct 14.

Medical Oncology Department, Centre Antoine Lacassagne, Nice, France.

Background: Treatment of osteosarcoma of the extremities consists of surgical resection preceded and followed by chemotherapy, including high-dose methotrexate or adriamycin-based protocols. When distant relapse occurs, therapeutic options are scarce. Trabectedin, a DNA-binding agent, is indicated for the treatment of patients with advanced soft tissue sarcomas after failure of anthracyclines and ifosfamide. Read More

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http://dx.doi.org/10.1159/000355664DOI Listing
June 2014
38 Reads

Venous thromboembolic events in germ cell cancer patients undergoing platinum-based chemotherapy.

Onkologie 2013 14;36(11):663-8. Epub 2013 Oct 14.

Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Germ cell tumor (GCT) patients are at risk of venous thromboembolic events (VTEEs). A higher incidence of VTEEs has been reported in GCT patients undergoing cisplatin-based chemotherapy.

Patients And Methods: A retrospective analysis of the incidence of and risk factors for VTEEs in 193 GCT patients receiving platinum-based chemotherapy in Hamburg, Germany, between 2000 and 2009 was performed. Read More

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http://dx.doi.org/10.1159/000355652DOI Listing
June 2014
11 Reads

A phase I dose escalation and pharmacodynamic study of SU5416 (semaxanib) combined with weekly cisplatin and irinotecan in patients with advanced solid tumors.

Onkologie 2013 14;36(11):657-60. Epub 2013 Oct 14.

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Medical Center, The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.

Background: This phase I study evaluated the safety of SU5416, a potent and selective inhibitor of the vascular endothelial growth factor (VEGF) receptor tyrosine kinase Flk-1, in combination with weekly cisplatin and irinotecan in patients with advanced solid tumors.

Methods: The patients received cisplatin 30 mg/m² and irinotecan 50 mg/m² weekly from week 1 to week 4, with SU5416 at either 65 mg/m² (dose level (DL)1) or 85 mg/m² (DL2) twice weekly for 6 weeks (1 cycle). Serial ¹⁸fluorodeoxyglucose-positron emission tomography (¹⁸FDG-PET) and ¹⁵O-H₂O-PET scans were obtained. Read More

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http://dx.doi.org/10.1159/000355665DOI Listing
June 2014
6 Reads

Far upstream element-binding protein 1 (FUBP1) is overexpressed in human gastric cancer tissue compared to non-cancerous tissue.

Onkologie 2013 14;36(11):650-5. Epub 2013 Oct 14.

Department of Gastroenterology, The General Hospital of Jinan Military Command, Jinan, Shandong Province, China.

Background: The aim of this study was to investigate the role of far upstream element-binding protein 1 (FUBP1) in gastric cancer development.

Patients And Methods: Using immunohistochemistry, we detected FUBP1 expression in 18 chronic superficial gastritis patients, 33 chronic atrophic gastritis patients, 21 moderate and severe gastric dysplasia patients, and 31 gastric cancer patients. FUBP1 mRNA expression in gastric cancer tissue and paraneoplastic tissue was measured with fluorescent quantitative reverse transcription polymerase chain reaction. Read More

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http://dx.doi.org/10.1159/000355659DOI Listing
June 2014
28 Reads

Characteristics, treatment and prognostic factors of patients with gynaecological malignancies treated in a palliative care unit at a university hospital.

Onkologie 2013 18;36(11):642-8. Epub 2013 Oct 18.

III. Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Universität Heidelberg, Germany.

Background: Limited clinical data have been published on patients suffering from advanced gynaecological malignancies treated in palliative care units, and little is known about prognostic factors.

Methods: In a retrospective study, the data of 225 patients with breast, ovarian and cervical cancer treated in the palliative care unit of a university hospital between 1998 and 2009 were assembled. Clinical aspects and baseline symptoms, laboratory parameters, the clinical course, and outcome were evaluated. Read More

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http://dx.doi.org/10.1159/000355642DOI Listing
June 2014
4 Reads

Clinical significance of lymph node ratio in locally advanced breast cancer molecular subtypes.

Onkologie 2013 14;36(11):637-40. Epub 2013 Oct 14.

Rize Recep Tayyip Erdogan University Hospital, Department of Radiation Oncology, Rize, Turkey.

Background: The ratio of metastatic to dissected lymph nodes (lymph node ratio; LNR) is a sensitive and superior prognostic factor for lymph node evaluation, but its relationship to cancer subtypes is unclear.

Patients And Methods: Data from 469 patients with axillary lymph node metastasis out of 640 early breast cancer cases were retrospectively analyzed. They were classified into 4 molecular subtypes; luminal A, luminal B HER2(+), HER2 overexpression, basal-like. Read More

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http://dx.doi.org/10.1159/000355663DOI Listing
June 2014
16 Reads

Clinical significance of joint detection of CD44v6 and CD62P in nasopharyngeal carcinoma.

Onkologie 2013 14;36(11):629-34. Epub 2013 Oct 14.

Aim: The aim of this study was to investigate the expression and clinical prognostic significance of adhesion molecules in nasopharyngeal carcinoma (NPC) tissues and peripheral blood.

Materials And Methods: Flow cytometry assays for the expression levels of CD44v6 and CD62P protein in peripheral blood and tissues from controls and NPC patients were performed. Clinical and pathological features were reported and analyzed, and a survival study was carried out. Read More

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http://dx.doi.org/10.1159/000356041DOI Listing
June 2014
5 Reads

Abstracts of the German, Austrian, and Swiss Society for Hematology and Oncology. October 18-22, 2013. Vienna, Austria.

Authors:

Onkologie 2013 17;36 Suppl 7:1-306. Epub 2013 Oct 17.

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http://dx.doi.org/10.1159/000356365DOI Listing
November 2013
2 Reads

[Tumor conference II].

Onkologie 2013 12;36 Suppl 6:14-6. Epub 2013 Aug 12.

Sektion Thorakale Onkologie und Pneumologie, Medizinische Klinik V, Campus Innenstadt, Klinikum der Universität München, Lungentumorzentrum München, Deutschland.

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http://dx.doi.org/10.1159/000353715DOI Listing
April 2014
4 Reads

[Tumor Conference I].

Onkologie 2013 12;36 Suppl 6:2-4. Epub 2013 Aug 12.

Abteilung Hämatologie und Onkologie, Universitätsmedizin Göttingen, Deutschland.

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http://dx.doi.org/10.1159/000353714DOI Listing
April 2014
3 Reads

PPARγ against tumors by different signaling pathways.

Onkologie 2013 17;36(10):598-601. Epub 2013 Sep 17.

Institute of Life Sciences, Jiangsu University, Zhenjiang, PR China.

The peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the nuclear hormone receptor superfamily, and is expressed in adipose tissue, skeletal muscle, spleen, heart, liver, placenta, lung, and ovary. PPARγ is a critical regulator of inflammation, adipocyte differentiation, glucose homeostasis, and tumorigenesis. The mechanism of PPARγ on tumor suppression is still unclear, but plenty of evidence shows that PPARγ provides new therapeutic targets for cancer. Read More

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http://dx.doi.org/10.1159/000355328DOI Listing
June 2014
2 Reads

Ubiquitin-proteasome pathway and prostate cancer.

Onkologie 2013 16;36(10):592-6. Epub 2013 Sep 16.

Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Prostate cancer is one of the most common cancers in men. Various signaling pathways and proteins are involved in prostate carcinogenesis. Ubiquitination and deubiquitination of the related proteins contribute to the development of prostate cancer in various ways. Read More

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http://dx.doi.org/10.1159/000355166DOI Listing
June 2014
2 Reads

Concomitant chemoradiotherapy and antiretroviral therapy for HIV-infected patients with locoregionally advanced non-small cell lung cancer: benefit and tolerability of treatment in 2 cases.

Onkologie 2013 17;36(10):586-90. Epub 2013 Sep 17.

Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious diseases Center, Komagome Hospital, Tokyo, Japan.

Background: Human immunodeficiency virus (HIV)-infected patients are surviving longer since the advent of antiretroviral therapy. Therefore, more patients are developing non-AIDS-defining cancers which increasingly determine mortality.

Case Reports: Here we present 2 cases of locally advanced non-small cell lung cancer treated initially with concomitant chemoradiotherapy and antiretroviral therapy. Read More

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http://dx.doi.org/10.1159/000355162DOI Listing
June 2014
8 Reads

Coinfection of Pneumocystis jirovecii and invasive pulmonary aspergillosis in an immunocompromised patient: a diagnostic challenge.

Onkologie 2013 16;36(10):582-4. Epub 2013 Sep 16.

Department of Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany.

Background: Invasive infections caused by Aspergillus fumigatus as well as Pneumocystis pneumonia are serious and often lethal diseases in severely immunocompromised patients.

Case Report: We report on a rare case of a pulmonary coinfection of Pneumocystis jirovecii and Aspergillus fumigatus in a 59-year-old female patient with a history of astrocytoma treated with high doses of corticosteroids and a subsequent CD4 lymphocyte count of 30/µl.

Conclusion: A heightened clinical awareness and a stringent and accurate diagnostic work-up encompassing diagnostic tools to detect even coincident fungal infections is crucial for sufficient and early antifungal treatment in immunocompromised patients with lung infiltrates. Read More

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http://dx.doi.org/10.1159/000355168DOI Listing
June 2014
6 Reads

Serum S100B levels correlate with clinical benefit in a metastatic melanoma patient treated by CTLA-4 blockade: a case report.

Onkologie 2013 17;36(10):578-81. Epub 2013 Sep 17.

Department of Dermatology, University of Mainz, Germany.

Background: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells. In patients with metastatic melanoma, anti-CTLA-4 antibody therapy with ipilimumab achieves durable cancer regression in approximately 10-15% of patients. In the face of complex and sometimes delayed tumor response patterns, prognostic and predictive biomarkers are needed to monitor therapy outcomes and to identify early potential long-term survivors who might also benefit from therapy re-induction. Read More

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http://dx.doi.org/10.1159/000355159DOI Listing
June 2014
2 Reads

Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.

Onkologie 2013 17;36(10):573-6. Epub 2013 Sep 17.

Department of Radiation Oncology, The First People's Hospital of Xuzhou, China.

Background: Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA hsa-mir-499 with the risk of gastric cancer (GC) in the Chinese population.

Patients And Methods: The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Read More

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http://dx.doi.org/10.1159/000355518DOI Listing
June 2014
47 Reads

Overexpression of CD40 in sacral chordomas and its correlation with low tumor recurrence.

Onkologie 2013 17;36(10):567-71. Epub 2013 Sep 17.

Department of Anesthesiology, China-Japan Union Hospital, Jilin University, China.

Aim: To determine the degree of CD40 overexpression in sacral chordomas and its correlation with tumor recurrence.

Methods: CD40 or CD31 overexpression was determined by immunohistochemical staining; the microvessel density (MVD) was calculated according to the CD31 expression. The correlation of CD40 over-expression with tumor recurrence was analyzed. Read More

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https://www.karger.com/Article/FullText/355334
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http://dx.doi.org/10.1159/000355334DOI Listing
June 2014
8 Reads

Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer.

Onkologie 2013 16;36(10):560-5. Epub 2013 Sep 16.

Department of Infection and Liver Diseases, Institution of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, China.

Background/aims: To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis.

Methods: An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis. Read More

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http://dx.doi.org/10.1159/000355158DOI Listing
June 2014
11 Reads

Prognostic factors for recurrence-free survival in patients with HER2-positive early-stage breast cancer treated with adjuvant trastuzumab.

Onkologie 2013 16;36(10):554-8. Epub 2013 Sep 16.

Division of Medical Oncology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: The objective of this study was to identify prognostic factors affecting the recurrence-free survival (RFS) in patients who received a 52-week trastuzumab therapy for HER2-positive early stage breast cancer (EBC).

Patients And Methods: The medical records of all patients with EBC from 10 centers were analyzed. Pathologic and clinical tumor characteristics were evaluated in 424 female patients who received 52 weeks of adjuvant trastuzumab for HER2-positive EBC. Read More

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http://dx.doi.org/10.1159/000355156DOI Listing
June 2014
90 Reads

Evaluation of selected speech parameters after prosthesis supply in patients with maxillary or mandibular defects.

Onkologie 2013 17;36(10):547-52. Epub 2013 Sep 17.

Department of ENT, University Hospital 'Carl Gustav Carus', Technische Universität Dresden, Germany.

Background: Ablative surgery of oropharyngeal tumors frequently leads to defects in the speech organs, resulting in impairment of speech up to the point of unintelligibility. The aim of the present study was the assessment of selected parameters of speech with and without resection prostheses.

Patients And Methods: The speech sounds of 22 patients suffering from maxillary and mandibular defects were recorded using a digital audio tape (DAT) recorder with and without resection prostheses. Read More

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http://dx.doi.org/10.1159/000355154DOI Listing
June 2014
4 Reads

Anxiety, posttraumatic stress, and fear of cancer progression in patients with melanoma in cancer aftercare.

Onkologie 2013 17;36(10):540-4. Epub 2013 Sep 17.

Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Essen, Germany.

Unlabelled: Several studies have described mental distress and anxiety in patients with melanoma. The findings of these studies varied from patients with a quality of life similar to the general population and those with increased mental distress. In the present study, we investigated anxiety, posttraumatic stress, and fear of cancer progression to gain a detailed picture of the burdens of these patients. Read More

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http://dx.doi.org/10.1159/000355137DOI Listing
June 2014
13 Reads

Afatinib, erlotinib and gefitinib in the first-line therapy of EGFR mutation-positive lung adenocarcinoma: a review.

Onkologie 2013 19;36(9):510-8. Epub 2013 Aug 19.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Germany.

Non-small cell lung cancer (NSCLC) consists of several histomorphologically defined phenotypes that display an enormous genetic variability. In recent years, epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma has emerged as a unique subset of NSCLC in terms of etiopathogenesis and tumor biology. Since the introduction of the reversible EGFR tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib, patients with metastatic EGFR mutation-positive lung cancer can be offered a therapeutic alternative that has proven its superiority over standard platinum-based chemotherapy. Read More

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http://dx.doi.org/10.1159/000354627DOI Listing
May 2014
6 Reads

A case of positive mixed epithelial/mesenchymal metaplastic breast carcinoma (carcinosarcoma). Towards novel therapeutic targets: case report.

Onkologie 2013 19;36(9):506-9. Epub 2013 Aug 19.

2nd Department of Propaedeutic Surgery, Athens University Medical School, Laiko General Hospital, Athens, Greece.

Background: Metaplastic breast cancer (MeBC) is a rare malignancy, representing less than 1% of all breast cancers. We present a case of triple-negative MeBC with a biphasic growth pattern, including malignant mesenchymal and epithelial components.

Case Report: A 45-year-old female patient presented to our hospital with a 1-month history of a lump in her right breast. Read More

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http://dx.doi.org/10.1159/000354638DOI Listing
May 2014
13 Reads

Antitumor effect of everolimus in a patient with type 3 gastric neuroendocrine tumor.

Onkologie 2013 16;36(9):502-4. Epub 2013 Aug 16.

Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.

Background: Gastric neuroendocrine tumors (NET) are rare and are classified into 3 types: type 1 and 2 (characterized by hypergastrinemia), and type 3 (characterized by normal gastrin). Surgery is the standard procedure, and systemic treatment is reserved for unresectable disease. Currently, targeted therapies are being evaluated in NET. Read More

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http://dx.doi.org/10.1159/000354637DOI Listing
May 2014
8 Reads

Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report.

Onkologie 2013 19;36(9):498-500. Epub 2013 Aug 19.

Saint Joseph Hospital, Raymond and Aida Najjar Medical Center, Beirut, Lebanon.

Background: Granulosa cell tumors (GCT) are malignant tumors of the sex cord stroma representing 5% of all malignant ovarian tumors. Their treatment is surgery, and rarely chemotherapy and radiotherapy. Recently, salvage treatment with aromatase inhibitors was suggested based on few reported clinical cases. Read More

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http://dx.doi.org/10.1159/000354635DOI Listing
May 2014
13 Reads

Prognostic significance of the number of removed lymph nodes at lobectomy in patients with positron emission tomography-computed tomography-negative N2 non-small cell lung cancer.

Onkologie 2013 19;36(9):492-6. Epub 2013 Aug 19.

Division of Thoracic Surgery, Department of Surgery, National Defence Medical Centre, Taiwan, ROC.

Background: We assessed the relation between the extent of lymph node (LN) dissection and the prognosis for positron emission tomography-computed tomography (PET-CT)-negative patients with clinical early-stage non-small cell lung cancer (NSCLC), undergoing lobectomy and mediastinal LN dissection.

Methods: 277 patients with clinical stage I/II NSCLC who had undergone a preoperative PET-CT scan followed by lobectomy were analysed retrospectively. The prognostic value of age, maximum standardized uptake value (SUVmax) of the tumour, tumour size, carcinoembryonic antigen and number of dissected LNs was assessed to determine any association with overall survival and disease-free survival. Read More

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http://dx.doi.org/10.1159/000354631DOI Listing
May 2014
8 Reads

Comparison of computed tomography- and positron emission tomography-based radiotherapy planning in cholangiocarcinoma.

Onkologie 2013 19;36(9):484-90. Epub 2013 Aug 19.

Department of Radiation Oncology, Baskent University Medical Faculty, Adana, Turkey.

Introduction: The aim of this study was to compare computed tomography (CT)- and positron emission tomography (PET)/CT-based gross tumor volume (GTV) delineation and its subsequent expansion to the planning target volume (PTV), and to analyze the resultant doses of 3-dimensional conformal radiotherapy (3D-CRT) to critical organs.

Methods: 15 patients with unresectable extrahepatic cholangiocarcinoma (EHCC) were enrolled into this study. PTVCT-based plans were initially made, and then PTVPET-CT-based plans were created using the same beam angles and isocenter. Read More

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http://dx.doi.org/10.1159/000354630DOI Listing
May 2014
6 Reads
3 Citations
0.840 Impact Factor

Outcome of early breast cancer treated in an urban and a rural breast cancer unit in Germany.

Onkologie 2013 19;36(9):477-82. Epub 2013 Aug 19.

Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssen-Stiftung/Knappschafts GmbH, Essen, Germany.

Background: Conflicting evidence has been published concerning survival disadvantages in the outcome of breast cancer patients in relationship to their residency in urban or rural communities.

Methods: The primary aim of this study was to evaluate differences in patients and treatment characteristics between an urban and a rural breast cancer unit. Therefore, all early breast cancer patients treated consecutively between 1999 and 2007 in a rural and an urban breast cancer unit were included. Read More

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http://dx.doi.org/10.1159/000354624DOI Listing
May 2014
16 Reads

Meta-analysis of the association between the IL-12B +1188 A/C polymorphism and cancer risk.

Onkologie 2013 19;36(9):470-5. Epub 2013 Aug 19.

Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: Because of inconsistent results from previous studies on the association of IL-12B +1188 A/C polymorphism with cancer risk, a meta-analysis was performed to assess the association.

Materials And Methods: A literature search was performed to identify all relevant studies to May 31, 2012, with a restriction to English and Chinese publications. Pooled data were estimated using a random-effects model. Read More

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http://dx.doi.org/10.1159/000354671DOI Listing
May 2014
13 Reads

[Management of tumors with neuroendocrine differentiation].

Onkologie 2013 12;36 Suppl 6:9-13. Epub 2013 Aug 12.

Klinik und Poliklinik für Nuklearmedizin, Ludwig-Maximilians-Universität München, München, Deutschland.

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http://dx.doi.org/10.1159/000353717DOI Listing
April 2014
5 Reads
0.840 Impact Factor

[Oncological therapies - what are the patient relative outcomes?].

Onkologie 2013 12;36 Suppl 6:5-8. Epub 2013 Aug 12.

Selbsthilfe für Lungenkrebs, Landesverband Baden-Württemberg, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

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http://dx.doi.org/10.1159/000353716DOI Listing
April 2014
2 Reads

[(Mis) management in healthcare].

Onkologie 2013 1;36 Suppl 5:20-7. Epub 2013 Jul 1.

Praxis für Internistische Onkologie und Hämatologie, Recklinghausen, Deutschland.

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http://dx.doi.org/10.1159/000352001DOI Listing
March 2014
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[New drugs in oncology: benefits, risks and challenges].

Onkologie 2013 1;36 Suppl 5:12-9. Epub 2013 Jul 1.

Department of Medical Social Sciences, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1159/000352000DOI Listing
March 2014
4 Reads

[Targeted therapy: old and new possibilities].

Onkologie 2013 1;36 Suppl 5:2-11. Epub 2013 Jul 1.

Abteilung Hämatologie/Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena, Deutschland.

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http://dx.doi.org/10.1159/000351997DOI Listing
March 2014
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microRNA-21 and its emerging role in tumor progression in systemic malignancies.

Onkologie 2013 28;36(7-8):451. Epub 2013 Jun 28.

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http://dx.doi.org/10.1159/000353693DOI Listing
March 2014
2 Reads

Temozolomide-related hematologic toxicity.

Onkologie 2013 8;36(7-8):444-9. Epub 2013 Jul 8.

Department of Radiation Oncology, St Andrea Hospital, University Sapienza, Rome, Italy.

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of recurrent or newly diagnosed malignant gliomas with significant survival benefit. TMZ is generally well tolerated and safe. The most common side effects are mild to moderate, and are represented by fatigue, nausea, vomiting, thrombocytopenia, and neutropenia. Read More

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http://dx.doi.org/10.1159/000353752DOI Listing
March 2014
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Fertility-sparing surgery in ovarian cancer: a systematic review.

Onkologie 2013 8;36(7-8):436-43. Epub 2013 Jul 8.

Dept. of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Germany.

Background: Ovarian cancer is rarely diagnosed in women of reproductive age; however, this coincidence seems to increase due to changes in lifestyle. Available evidence on the prognostic impact of fertility-sparing surgery (FSS) is sparse, and there is an emerging need to consolidate such evidence.

Materials And Methods: Systematic review of the literature, including testing for heterogeneity and meta-analytical odds ratio (OR) calculations. Read More

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http://dx.doi.org/10.1159/000353598DOI Listing
March 2014
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Exploration of the role of radiotherapy in the management of early glottic cancer with complete carotid artery occlusion.

Onkologie 2013 8;36(7-8):433-5. Epub 2013 Jul 8.

Department of Radiation Oncology, Beth Israel Medical Center, New York, NY, USA.

Background: The aim of this study was to compare intensity-modulated radiation therapy (IMRT) vs. 2D and 3D radiotherapy (RT) in the treatment of T1 glottic squamous cell carcinoma in an effort to highlight the advantages of IMRT in this particular clinical situation.

Case Report: We present the case of an 82-year-old female patient with T1 left true vocal cord squamous cell carcinoma and complete occlusion of the left carotid artery resulting in multiple strokes. Read More

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http://dx.doi.org/10.1159/000353750DOI Listing
March 2014
3 Reads