10,100 results match your criteria Oncology letters[Journal]


Development of QSAR machine learning-based models to forecast the effect of substances on malignant melanoma cells.

Oncol Lett 2019 May 25;17(5):4188-4196. Epub 2019 Feb 25.

Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

SK-MEL-5 is a human melanoma cell line that has been used in various studies to explore new therapies against melanoma in different experiments. Based on this study we report on the development of quantitative structure-activity relationship (QSAR) models able to predict the cytotoxic effect of diverse chemical compounds on this cancer cell line. The dataset of cytotoxic and inactive compounds were downloaded from the PubChem database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466999PMC

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma.

Oncol Lett 2019 May 4;17(5):4717-4725. Epub 2019 Mar 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 and 2010 was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447886PMC
May 2019
1 Read

Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first-line therapy in patients with extensive-stage small cell lung cancer.

Oncol Lett 2019 May 8;17(5):4701-4709. Epub 2019 Mar 8.

Department of Biostatistics, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China.

The majority of previous studies of lobaplatin in small cell lung cancer (SCLC) are small phase I-II studies. The present study aimed to verify the non-inferiority (in terms of efficacy) of lobaplatin plus etoposide (EL) vs. cisplatin plus etoposide (EP) in patients with previously untreated extensive-stage SCLC (ES-SCLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447897PMC
May 2019
1 Read

Identification of key pathways and genes in nasopharyngeal carcinoma using bioinformatics analysis.

Oncol Lett 2019 May 8;17(5):4683-4694. Epub 2019 Mar 8.

Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, P.R. China.

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck. The aim of the current study was to identify the key pathways and genes involved in NPC through bioinformatics analysis and to identify potential molecular mechanisms underlying NPC proliferation and progression. Three gene expression profiles (GSE12452, GSE34573 and GSE64634) were downloaded from the Gene Expression Omnibus database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447945PMC
May 2019
1 Read

Comparison of diagnostic methods for the detection of a BRAF mutation in papillary thyroid cancer.

Oncol Lett 2019 May 8;17(5):4661-4666. Epub 2019 Mar 8.

Department of Thyroid and Neck Tumor, Key Laboratory of Cancer Immunology and Biotherapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China.

The most common genetic alteration identified in papillary thyroid cancer (PTC) encodes a valine to glutamic acid change at position 600 (V600E) in the BRAF proto-oncoprotein. The most accurate and reliable method for detecting this BRAF mutation has not yet been determined. In the present study, the sensitivity, specificity and feasibility of diagnostic methods for BRAF mutations were assessed. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10131
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447932PMC
May 2019
2 Reads

IL-32 expression indicates unfavorable prognosis in patients with colon cancer.

Oncol Lett 2019 May 12;17(5):4655-4660. Epub 2019 Mar 12.

Department of General Surgery, The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.

Recently, interleukin (IL)-32 has been demonstrated to represent a novel biomarker for evaluating the prognosis of patients with gastric and lung cancer; however, its clinical significance in colon cancer remains unknown. In the present study, the IL-32 expression in 60 patients with colon cancer was examined with an immunohistochemistry assay. IL-32 expression was determined in 37 (61. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447918PMC

The stem cell-specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer.

Oncol Lett 2019 May 4;17(5):4647-4654. Epub 2019 Mar 4.

Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan.

The intermediate filament nestin is upregulated in stem/progenitor cells and cancers, and regulates cell proliferation, migration, invasion and stemness. The present study comparatively analyzed serial autopsies of Japanese patients (n=2,206; males, 1,225; females, 981; median, 80.7 years old; range, 33-104 years old) with malignant tumors of whole organs, with respect to the clinical information, and 5 single nucleotide polymorphisms of the nestin gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447929PMC
May 2019
1 Read

Expression of CLDN6 in tissues of gastric cancer patients: Association with clinical pathology and prognosis.

Oncol Lett 2019 May 8;17(5):4621-4625. Epub 2019 Mar 8.

Department of Oncology (I), Central Hospital of Zibo, Zibo, Shandong 255036, P.R. China.

Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013. Cancer and normal adjacent tissues were obtained from the patients to detect the expression level of CLDN6 using reverse transcription-quantitative PCR (RT-qPCR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447906PMC
May 2019
2 Reads

Interleukin-8 promotes prostate cancer bone metastasis through upregulation of bone sialoprotein.

Oncol Lett 2019 May 12;17(5):4607-4613. Epub 2019 Mar 12.

Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China.

The aim of the present study was to investigate whether interleukin-8 (IL-8) enhances the ability of prostate cancer bone metastasis by influencing the coding level of bone sialoprotein (BSP). Cultured prostate cancer cell lines LNCaP (androgen dependent) and DU145 (androgen independent) were divided into three groups: IL-8 treatment group; IL-8 receptor inhibitor (SB225002) treatment group; and control group. Western blotting and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used to detect BSP protein and mRNA expression levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447917PMC

The potential role of miR-126, miR-21 and miR-10b as prognostic biomarkers in renal cell carcinoma.

Oncol Lett 2019 May 12;17(5):4566-4574. Epub 2019 Mar 12.

Department of Urology, Faculty of Medicine and Health, Örebro University, 701 85 Örebro, Sweden.

Renal cell carcinoma (RCC) is the most commonly diagnosed renal tumor, consisting of ~3% of all malignancies worldwide. The prognosis of RCC can vary widely, and detecting patients at risk of recurrence at an early stage of disease may improve patient outcome. The factors presently used in a clinical setting cannot reliably predict the natural history of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447904PMC
May 2019
1 Read

Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.

Oncol Lett 2019 May 12;17(5):4514-4520. Epub 2019 Mar 12.

Department of General Surgery, Taihe Hospital Affiliated with Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.

Metadherin (MTDH) is a protein that is also named astrocyte elevated gene-1, and is highly expressed in a number of different tumor tissues. Although the expression of MTDH is associated with tumor invasion and recurrence, the expression of this protein in perihilar cholangiocarcinoma (PCCA) and its clinical use have not yet been investigated. In the present study, the expression of MTDH in patients with PCCA was investigated in order to determine its clinicopathological use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447862PMC
May 2019
1 Read

Five-long non-coding RNA risk score system for the effective prediction of gastric cancer patient survival.

Oncol Lett 2019 May 8;17(5):4474-4486. Epub 2019 Mar 8.

Department of Gastrointestinal Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.

The prognosis for patients with gastric cancer (GC) is usually poor, as the majority of patients have reached the advanced stages of disease at the point of diagnosis. Therefore, revealing the mechanisms of GC is necessary for the identification of key biomarkers and the development of effective targeted therapies. The present study aimed to identify long non-coding RNAs (lncRNAs) prominently expressed in patients with GC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447923PMC
May 2019
1 Read

Exosomes from LNCaP cells promote osteoblast activity through miR-375 transfer.

Oncol Lett 2019 May 5;17(5):4463-4473. Epub 2019 Mar 5.

Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P.R. China.

Previous studies have revealed that exosomes influence tumour metastasis, diagnosis and treatment. In addition, exosomal microRNAs (miRNAs/miRs) are closely associated with the metastatic microenvironment; however, the regulatory role of exosomal miRNAs from prostate cancer cells on bone metastasis remains poorly understood. In the present study, a series of experiments were performed to determine whether exosomal miR-375 from LNCaP cells promote osteoblast activity. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10110
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447935PMC
May 2019
2 Reads
0.987 Impact Factor

Cyclin A is a reliable proliferation marker in endometrial cancer cell lines.

Oncol Lett 2019 May 8;17(5):4455-4462. Epub 2019 Mar 8.

Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.

Cyclin A, a cell cycle regulatory protein, promotes cell proliferation and has been observed to be highly expressed in cancer and to promote tumor growth; however, its value as a marker for endometrial carcinoma has not yet been established. Accordingly, the aim of the present study was to clarify whether cyclin A can be used as a cell proliferation marker using the endometrial carcinoma cell lines Ishikawa and HEC-50B, derived from patients with low-grade and high-grade cancer, respectively. The expression of cyclin A was determined by flow cytometry using double staining with FITC and 7-AAD, and immunocytochemical staining. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10135
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447861PMC
May 2019
1 Read

Expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer and their effects on the biological characteristics of bladder cancer cells.

Oncol Lett 2019 May 12;17(5):4437-4442. Epub 2019 Mar 12.

Department of Emergency, Hunan Provincial People's Hospital, Changsha, Hunan 410005, P.R. China.

Changes in the expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer tissues were studied. A total of 30 patients with bladder cancer who had surgical resection in the Hunan Provincial People's Hospital (Changsha, China) from April 2015 to August 2016 were selected. RT-qPCR was used to detect the expression levels of miR-490-5p, miR-148a-3p and miR-608. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447928PMC

Efficacy and association analysis of high-dose methotrexate in the treatment of children with acute lymphoblastic leukemia.

Oncol Lett 2019 May 8;17(5):4423-4428. Epub 2019 Mar 8.

Ward 6, Department of Pediatrics, The People's Hospital of Pingyi County, Linyi, Shandong 273300, P.R. China.

Effect of high-dose methotrexate (MTX) on children with acute lymphoblastic leukemia (ALL) with different subtypes and disease courses was investigated. A retrospective analysis of 207 children with ALL who were admitted to the People's Hospital of Pingyi County from March 2014 to June 2017 was carried out. According to the subtype of the disease, the children were divided into two groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447950PMC
May 2019
1 Read

RANBP9 suppresses tumor proliferation in colorectal cancer.

Oncol Lett 2019 May 8;17(5):4409-4416. Epub 2019 Mar 8.

Department of General Surgery, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China.

RAN binding protein 9 (RANBP9) is widely expressed in mammalian tissues, including osteosarcoma, lung, gastric and breast cancer tissues. However, currently, not much is known about the role of RANBP9 in colorectal cancer (CRC). In the present study, RANBP9 expression in CRC tissues and cell lines was measured by immunohistochemistry and western blotting, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447939PMC
May 2019
2 Reads

Clinical significance of BRCA1 and BRCA2 mRNA and protein expression in patients with sporadic gastric cancer.

Oncol Lett 2019 May 8;17(5):4383-4392. Epub 2019 Mar 8.

Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.

The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated () gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy. Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expression and mRNA expression were evaluated using immunohistochemistry (IHC) and hybridization (ISH) on tissue GC microarray tissues, in addition to reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The results were analyzed for clinicopathological associations. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10132
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447901PMC
May 2019
1 Read

Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.

Oncol Lett 2019 May 12;17(5):4361-4368. Epub 2019 Mar 12.

Department of 2016 Levels of Integrated Traditional Chinese and Western Medicine Clinical Oncology, Liaoning University of Traditional Chinese Medicine Graduate School, Shenyang, Liaoning 110847, P.R. China.

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) is frequently downregulated or lost in numerous types of cancer, including liver cancer. The aim of the present study was to examine whether demethylation of the HACE1 gene could inhibit tumour progression. The expression of HACE1 was detected in liver cancer cell lines. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10139
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447922PMC
May 2019
1 Read

AMP-activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer.

Oncol Lett 2019 May 8;17(5):4329-4334. Epub 2019 Mar 8.

Department of Respiratory Medicine, Subei People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.

AMP-activated protein kinase α1 (AMPK α1) is involved in the tumorigenesis of various cancer types. However, the role of AMPK α1 in non-small cell lung cancer (NSCLC) remains unclear. In the present study, 99 NSCLC tumor tissues and paired normal tissues were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447888PMC
May 2019
1 Read

Identification of key genes involved in the metastasis of clear cell renal cell carcinoma.

Oncol Lett 2019 May 8;17(5):4321-4328. Epub 2019 Mar 8.

Department of Medical Oncology, Affiliated Langdong Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

Clear cell renal cell carcinoma (ccRCC) is the most common and lethal renal malignant tumor in adults. The aim of the present study was to identify the key genes involved in ccRCC metastasis. Expression profiling data for ccRCC patients with metastasis and without metastasis were obtained from The Cancer Genome Atlas database. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10130
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447949PMC
May 2019
2 Reads

Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF-β1.

Oncol Lett 2019 May 12;17(5):4285-4292. Epub 2019 Mar 12.

Department of Respiration, The First Affiliated Hospital of Henan University of CM, Zhengzhou, Henan 450000, P.R. China.

Asiatic acid (AA) is a pentacyclic triterpenoid isolated from (L.) Urban that possesses significant antitumor activities. In the present study, the mechanism of AA on transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) was investigated in the lung cancer cell line A549. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447948PMC

A four-gene signature for prognosis in breast cancer patients with hypermethylated IL15RA.

Oncol Lett 2019 May 12;17(5):4245-4254. Epub 2019 Mar 12.

Department of Medical Oncology, Nanjing Medical University Suzhou Hospital, Suzhou Cancer Center, Suzhou, Jiangsu 215001, P.R. China.

Previous studies have revealed that upregulation of interleukin 15 receptor α (IL15RA) contributes to improved prognosis of breast cancer. The present study aimed to elucidate the molecular mechanisms underlying the antitumor effect induced by IL15RA upregulation, and to identify a gene signature capable of predicting the survival of patients with breast cancer. Using paired gene expression and methylation data of breast cancer samples from The Cancer Genome Atlas data portal, differentially expressed genes (DEGs) were identified in hypermethylated and hypomethylated IL15RA breast cancer samples. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10137
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447940PMC
May 2019
3 Reads

Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma.

Oncol Lett 2019 May 8;17(5):4222-4228. Epub 2019 Mar 8.

Experimental Center, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.

Hepatocellular carcinoma (HCC) is more frequently observed and aggressive in men compared with women. Increasing evidence demonstrates that the sex disparity appears to be mediated by the stimulatory effects of androgens and the protective effects of estrogen in the development and progression of HCC. In the past few decades, studies on the sex difference of HCC mainly focused on the effect of sex hormones on the transactivation of hepatitis B virus X protein and the release of inflammatory cytokines, and these studies have further intensified in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447942PMC
May 2019
1 Read

Discovery of LDD-1075 as a potent FLT3 inhibitor.

Oncol Lett 2019 May 1;17(5):4735-4741. Epub 2019 Mar 1.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do 52828, Republic of Korea.

Fms-like tyrosine kinase 3 (FLT3) is a valuable pharmacological target in the treatment of acute myeloid leukemia (AML). LDD-1075 and LDD-1076 are indirubin derivatives, and LDD-1075 is the ester form of LDD-1076. LDD-1076 exhibited a potent FLT3 kinase activity inhibition with an IC of 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444428PMC
May 2019
3 Reads
0.987 Impact Factor

Association between TP53 genetic polymorphisms and the methylation and expression of miR-34a, 34b/c in colorectal cancer tissues.

Oncol Lett 2019 May 1;17(5):4726-4734. Epub 2019 Mar 1.

Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.

Colorectal cancer (CRC) is one of the most common types of cancers, as evidenced by the >1.2 million patient diagnoses and 600,000 mortalities globally each year. Recently, the microRNA (miR/miRNA)-34 miRNA precursor family was revealed to participate in the tumor protein (TP)-53 pathway, which is frequently involved in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444414PMC
May 2019
1 Read

L-Lactate dehydrogenase B may be a predictive marker for sensitivity to anti-EGFR monoclonal antibodies in colorectal cancer cell lines.

Oncol Lett 2019 May 26;17(5):4710-4716. Epub 2019 Feb 26.

Department of Clinical Pharmacology and Therapeutics, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

Recently, proteins derived from cancer cells have been widely investigated as biomarkers for predicting the efficacy of chemotherapy. In this study, to identify a sensitive biomarker for the efficacy of anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs), proteins derived from 6 colorectal cancer (CRC) cell lines with different sensitivities to cetuximab, an anti-EGFR mAb, were analyzed. Cytoplasmic and membrane proteins extracted from each CRC cell line were digested using trypsin and analyzed comprehensively using mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444471PMC

Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X-chromosome inactivation pattern.

Oncol Lett 2019 May 4;17(5):4695-4700. Epub 2019 Mar 4.

Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.

Patients with papillary thyroid carcinoma (PTC) usually have multiple tumors, or foci. It remains unclear if these foci originate from independent tumors or a single tumor mass. The present study included 89 female patients with bilateral PTC who had been treated with a total thyroidectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444472PMC
May 2019
2 Reads

Aspirin inhibits colon cancer cell line migration through regulating epithelial-mesenchymal transition via Wnt signaling.

Oncol Lett 2019 May 28;17(5):4675-4682. Epub 2019 Feb 28.

Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

The mechanism responsible for the initiation of tumor metastasis and epithelial-mesenchymal transition (EMT) is not well understood. During EMT, epithelial cells lose their polarity and adhesion to surrounding cells and migrate, resulting in transition into mesenchymal cells. Canonical Wnt signaling has been implicated in controlling gene transcription and body axis pattern formation during development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444426PMC

TNFAIP8 promotes cisplatin resistance in cervical carcinoma cells by inhibiting cellular apoptosis.

Oncol Lett 2019 May 26;17(5):4667-4674. Epub 2019 Feb 26.

Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, Henan 475004, P.R. China.

Cervical cancer is the second most prevalent malignant tumor in women worldwide. Failure of successful treatment is most prevalent in patients with the metastatic disease and the chemotherapy refractory disease. Tumor necrosis factor α-induced protein 8 (TNFAIP8) serves as an anti-apoptotic and pro-oncogenic protein, and is associated with cancer progression and poor prognosis in a number of different cancer types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444441PMC
May 2019
5 Reads
0.987 Impact Factor

Overexpression of malignant brain tumor domain containing protein 1 predicts a poor prognosis of prostate cancer.

Oncol Lett 2019 May 5;17(5):4640-4646. Epub 2019 Mar 5.

Department of Urology, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.

Malignant brain tumor domain containing protein 1 (MBTD1) is a member of the polycomb group protein family that is associated with tumorigenesis. The present study investigated the role of MBTD1 within defined clinicopathological parameters and the prognosis of patients with prostate cancer (PCa). A human tissue microarray containing samples from 71 patients with PCa and seven healthy donors was employed for immunohistochemistry (IHC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444442PMC
May 2019
2 Reads
0.987 Impact Factor

Linc-pint inhibits early stage pancreatic ductal adenocarcinoma growth through TGF-β pathway activation.

Oncol Lett 2019 May 5;17(5):4633-4639. Epub 2019 Mar 5.

Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Long intergenic non-protein coding RNA, p53 induced transcript (Linc-pint) is a newly identified long non-coding RNA, which has demonstrated antitumor activities in various types of cancer. The present study aimed to investigate the role of Linc-pint in pancreatic ductal adenocarcinoma (PDAC). Plasma samples from patients with PDAC, and PDAC and normal cell lines were used in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444384PMC
May 2019
0.987 Impact Factor

Expression and clinical significance of SLP-2 in ovarian tumors.

Oncol Lett 2019 May 5;17(5):4626-4632. Epub 2019 Mar 5.

Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

The expression and clinical significance of stomatin-like protein 2 (SLP-2) in ovarian tumors were investigated. A total of 280 cases of ovarian tissue specimens preserved from inpatients after surgical treatments in the Department of Oncology of Yidu Central Hospital of Weifang from April 2013 to May 2016 were collected, including 130 cases of malignant ovarian tumor tissue specimens (malignant tumor group), 75 cases of benign ovarian tumor tissue specimens (benign tumor group) and 75 cases of normal ovarian tissue specimens from bilateral ovariectomy for unilateral ovarian lesions (control group). Immunohistochemistry was used to detect the expression of SLP-2 protein in the three groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444406PMC
May 2019
4 Reads

Evaluation of the prognostic significances of γ-secretase genes in pancreatic cancer.

Oncol Lett 2019 May 5;17(5):4614-4620. Epub 2019 Mar 5.

Department of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes, including presenilin (), nicastrin (), presenilin enhancer protein 2 (), and anterior pharynx-defective 1 (-), could serve as prognostic factors for pancreatic cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444455PMC
May 2019
2 Reads

Distinctive clinicopathological features of Von Hippel-Lindau-associated hereditary renal cell carcinoma: A single-institution study.

Oncol Lett 2019 May 1;17(5):4600-4606. Epub 2019 Mar 1.

Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China.

Von Hippel-Lindau (VHL) disease is a genetic syndrome that involves the development of tumors in numerous organs. The kidney is one of the most frequently affected organs, and patients with VHL and renal tumors require repeated nephrectomy. The present study aimed to further determine the clinicopathological characteristics of patients with VHL-associated renal cell carcinoma (RCC), which may allow more rational clinical treatment decisions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444392PMC
May 2019
2 Reads

Correlation of miR-425-5p and IL-23 with pancreatic cancer.

Oncol Lett 2019 May 4;17(5):4595-4599. Epub 2019 Mar 4.

Department of Radiotherapy, Weifang Medical University Hospital, Weifang, Shandong 261031, P.R. China.

The aim of this study was to detect the levels of miR-425-5p and IL-23 in tissues of pancreatic cancer patients and to explore their effects on pancreatic cancer. A retrospective analysis of 76 cases of pancreatic cancer tissue specimens and normal fresh tissue specimens at 50 mm adjacent to the corresponding cancer surgically resected in the first diagnosis was performed, in the Department of Radiotherapy of Traditional Chinese Medical Hospital of Huangdao District and Weifang Medical University Hospital from October 2015 to October 2016. RT-qPCR was used to detect miR-425-5p levels in pancreatic cancer and adjacent tissues, and ELISA to detect IL-23 levels in the tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444423PMC

Influence of obesity on surgical complications of patients with ovarian tumors.

Authors:
Huimin Lv Suhui Wu

Oncol Lett 2019 May 4;17(5):4590-4594. Epub 2019 Mar 4.

Department of Gynaecology and Obstetrics, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi 030000, P.R. China.

Influence of obesity on surgical complications and survival of patients with ovarian tumors were investigated. In total, 362 patients who were diagnosed with ovarian cancer by biopsy in the Department of Pathology of Shanxi Dayi Hospital Affiliated to Shanxi Medical University from April 2012 to July 2017 were selected as research subjects for retrospective analysis. The patients were divided into the obesity group [body mass index (BMI) ≥28] (n=64), the overweight group (≥24 BMI <28) (n=124), the normal body weight group (≥18. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444483PMC
May 2019
2 Reads

Expression of p53 and PTEN in human primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis and study of their concomitant expression.

Oncol Lett 2019 May 1;17(5):4575-4589. Epub 2019 Mar 1.

First Pathology Department, Medical School, National Kapodistrian University, Athens 11527, Greece.

Endometrial carcinoma is a common malignancy of the female genital tract. Alterations in the expression levels of various oncogenes and tumor suppressor genes serve important roles in the carcinogenesis and biological behavior of endometrial carcinoma. The aim of the present study was to evaluate the combination and individual expression of p53 and phosphatase and tensin homolog (PTEN) protein in human endometrial carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444490PMC
May 2019
3 Reads

Stromal tumor-infiltrating lymphocytes evaluated on H&E-stained slides are an independent prognostic factor in epithelial ovarian cancer and ovarian serous carcinoma.

Oncol Lett 2019 May 1;17(5):4557-4565. Epub 2019 Mar 1.

Department of Pathology, Pusan National University Hospital, Seo-Gu, Busan 602-739, Republic of Korea.

Studies on tumor-infiltrating lymphocytes (TILs) in epithelial ovarian cancer (EOC) have focused on the clinical significance of inflammatory cells of specific subtypes that are identifiable using immunohistochemistry. However, the subtypes of inflammatory cells that reportedly affect patient survival and prognosis have differed from study to study, and few studies have examined TILs using hematoxylin and eosin (H&E) staining. Therefore, the present study aimed to identify the clinical importance of general stromal TILs in EOC by using H&E staining to apply breast cancer recommendations from the International TILs Working Group 2014 on breast cancer using H&E staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444488PMC
May 2019
1 Read

Expression of LDH and CEA in serum in the process of targeted therapy of lung adenocarcinoma and the association between them and prognosis.

Oncol Lett 2019 May 5;17(5):4550-4556. Epub 2019 Mar 5.

The Second Department of Oncology, The First People's Hospital of Chuzhou, Chuzhou, Anhui 239000, P.R. China.

Expression of lactate dehydrogenase (LDH) and carcinoembryonic antigen (CEA) in serum was investigated in the process of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) targeting for treating lung adenocarcinoma and the association between LDH, CEA and prognosis of patients was evaluated. A retrospective analysis of 89 patients with lung adenocarcinoma admitted to The First People's Hospital of Chuzhou from January 2014 to February 2015 was performed. Fifty-one patients who received resection were considered the operation group, while the other 38 patients received EGFR-TKI targeted therapy and were considered the targeted group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444382PMC
May 2019
1 Read
0.987 Impact Factor

Value of differential diagnosis of contrast-enhanced ultrasound in benign and malignant thyroid nodules with microcalcification.

Oncol Lett 2019 May 4;17(5):4545-4549. Epub 2019 Mar 4.

Department of Ultrasound, People's Hospital of Shanxi Province, Taiyuan, Shanxi 030012, P.R. China.

Value of differential diagnosis of contrast-enhanced ultrasound in benign and malignant thyroid nodules with microcalcification was explored. A total of 184 patients with thyroid nodules with microcalcification, treated in People's Hospital of Shanxi Province from April 2015 to March 2017, were selected as research subjects. Contrast-enhanced ultrasound was used for imaging examination of the thyroid nodules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444473PMC

Label-free microfluidic chip for the identification of mesothelial cell clusters in pleural effusion.

Oncol Lett 2019 May 6;17(5):4532-4544. Epub 2019 Mar 6.

Department of Laboratory Science, School of Laboratory Medicine, Tianjin Medical University, Tianjin 300203, P.R. China.

The detection of tumor cells and clusters in pleural effusion assists in the diagnosis of lung cancer. The proportion of tumor cells and clusters to the total number of cells in each patient varies substantially due to individual differences and the severity of the disease. The identification of one tumor cell or cluster from a large number of pleural effusions is the main challenge for hydrothorax tumor cell detection techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444474PMC
May 2019
1 Read

Cytokines secreted by human Wharton's jelly stem cells inhibit the proliferation of ovarian cancer (OVCAR3) cells .

Oncol Lett 2019 May 1;17(5):4521-4531. Epub 2019 Mar 1.

Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.

Cytokines enhance tumour cell recognition via cytotoxic effector cells and are therefore effectively used in cancer immunotherapy. Mesenchymal stem cells have efficient homing potential and have been used to target and inhibit various types of cancer mediated by the release of soluble/bioactive factors. Initial evaluation of the human Wharton's jelly stem cell conditioned medium (hWJSC-CM) and cell lysate (hWJSC-CL) against an ovarian cancer cell line (OVCAR3) demonstrated their inhibitory effect . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444458PMC
May 2019
3 Reads

Polydatin inhibits hepatocellular carcinoma via the AKT/STAT3-FOXO1 signaling pathway.

Oncol Lett 2019 May 7;17(5):4505-4513. Epub 2019 Mar 7.

Department of Abdominal Ultrasonography, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Polydatin, extracted from , is known for its anti-platelet aggregation and anti-inflammatory effects. However, studies on the association of polydatin with cancer are limited, particularly with regards to epithelial-mesenchymal transition (EMT)-associated migration and invasion of cancer cells. The purpose of the present study was to reveal the potential anticancer effects of polydatin on hepatocellular carcinoma (HCC) cells, particularly its effects on EMT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444395PMC
May 2019
2 Reads

Candidate genes and potential mechanisms for chemoradiotherapy sensitivity in locally advanced rectal cancer.

Oncol Lett 2019 May 28;17(5):4494-4504. Epub 2019 Feb 28.

Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

The aim of the present study was to investigate candidate genes for chemoradiotherapy (CRT) sensitivity in patients with locally advanced rectal cancer (LARC), and the potential mechanisms of their action. A microarray dataset (GSE98959) was obtained from the Gene Expression Omnibus database that included microRNA (miRNA, miR) expression profiling of 22 samples from patients with LARC who had received preoperative radiotherapy and chemotherapy. Of these patients, 10 responded to the treatment and 12 did not. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10087
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444485PMC
May 2019
4 Reads

c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells.

Oncol Lett 2019 May 28;17(5):4487-4493. Epub 2019 Feb 28.

Department of Oncology, Lihuili Hospital of Ningbo Medical Center, Ningbo, Zhejiang 315000, P.R. China.

Cancer stem cells (CSCs) are responsible for cancer formation, recurrence and drug resistance. c-Myc, one of the core markers for stem cells, has recently been considered to serve as a link between malignancy and 'stemness'. However, the precise function of c-Myc in colon CSCs is still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444394PMC

Effect of submucosal injection of normal saline and glycerol fructose on endoscopic polypectomy in patients with colorectal polyps.

Oncol Lett 2019 May 6;17(5):4449-4454. Epub 2019 Mar 6.

Department of Gastroenterology, Qingdao Chengyang People's Hospital, Qingdao, Shandong 266109, P.R. China.

Effect of submucosal injection of normal saline and glycerol fructose on endoscopic polypectomy in patients with colorectal polyps was investigated. A total of 275 patients with colorectal polyps were enrolled in this study and underwent endoscopic gastrointestinal polypectomy in Qingdao Chengyang People's Hospital from March 2013 to December 2016. Among them, 150 patients who underwent submucosal injection of glycerol fructose were set as the experimental group, and 125 patients who underwent submucosal injection of normal saline were set as the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444498PMC
May 2019
1 Read

Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function.

Oncol Lett 2019 May 26;17(5):4443-4448. Epub 2019 Feb 26.

Department of Anesthesia, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China.

Effect of sevoflurane inhalation combined with epidural anesthesia on postoperative perceptual function in patients with colorectal cancer (CRC) was investigated. The clinical data of 78 patients undergoing laparoscopic CRC radical surgery in The Second Cancer Hospital of Heilongjiang Province from June 2016 to June 2017 were retrospectively analyzed and divided into 2 groups: Sevoflurane inhalation combined with epidural anesthesia (observation group, n=40); propofol intravenous general anesthesia (control group, n=38). The mean arterial pressure and heart rate before anesthesia (T0), immediate intubation (T1), 30 min after surgery started (T2), end of surgery (T3), 10 min after extubation (T4) were compared between the two groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444396PMC
May 2019
0.987 Impact Factor

5-Fluorouracil-based adjuvant chemotherapy improves the clinical outcomes of patients with lymphovascular invasion of upper urinary tract cancer and low expression of dihydropyrimidine dehydrogenase.

Oncol Lett 2019 May 28;17(5):4429-4436. Epub 2019 Feb 28.

Department of Urology, Dokkyo Medical University, Tochigi 321-0293, Japan.

Lymphovascular invasion (LVI) by urothelial carcinoma of the upper urinary tract (UC-UUT) is associated with an unfavorable prognosis. However, a high proportion of patients with UC-UUT are unable to receive the recommended doses of cisplatin-based adjuvant chemotherapy due to advanced age or renal dysfunction resulting from nephroureterectomy. Tegafur-uracil is an oral form of 5-fluorouracil whose efficacy is influenced by the activities of enzymes associated with its metabolism, such as dihydropyrimidine dehydrogenase (DPD), orotatephosphoribosyltransferase (OPRT) and thymidylate synthase (TS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2019.10086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444440PMC
May 2019
2 Reads