9,830 results match your criteria Oncology letters[Journal]


Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest.

Oncol Lett 2019 Feb 28;17(2):2171-2176. Epub 2018 Dec 28.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

The sirtuins (SIRTs) are a family of nicotinamide-adenine dinucleotide (NAD)-dependent protein deacetylases. SIRT4 is a mitochondrial NAD-dependent adenosine diphsophate-ribosyltransferase. Recent studies demonstrated that SIRT4 can regulate glutamine metabolism and thus act as a tumor suppressor. Read More

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http://dx.doi.org/10.3892/ol.2018.9877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350193PMC
February 2019
1 Read

Dendritic cell subpopulations in nasopharyngeal cancer.

Oncol Lett 2019 Feb 14;17(2):2557-2561. Epub 2018 Dec 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Skåne University Hospital, Lund SE-221 85, Sweden.

Nasopharyngeal cancer (NPC) is associated with Epstein-Barr virus (EBV) and EBV antigen may be utilized for therapeutic purposes, including targeting of dendritic cells (DCs). Although DCs may be present in NPC, the information is limited and not up-to-date with current knowledge on DC subsets. In the present study, biopsies from untreated NPC were obtained and subjected to multicolor flow-cytometry focusing on DC subtype markers: CD123 for plasmacytoid DCs (pDCs); and CD1c and CD141 for myeloid DCs (mDCs). Read More

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http://dx.doi.org/10.3892/ol.2018.9835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350184PMC
February 2019

Inflammatory biomarkers in prognostic analysis for patients with glioma and the establishment of a nomogram.

Oncol Lett 2019 Feb 24;17(2):2516-2522. Epub 2018 Dec 24.

Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Being biomarkers that reflect host nutritional and immune status, prognostic nutritional index (PNI) and neutrophil/lymphocyte ratio (NLR) have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of these parameters for the prognosis of patients with glioma. Hematological and clinicopathological data were retrospectively analyzed from 128 patients with glioma who underwent brain tumor resection between January 2008 and December 2012. Read More

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http://dx.doi.org/10.3892/ol.2018.9870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351731PMC
February 2019
1 Read

Effect on macrophage proliferation of a novel polysaccharide from (L. ex Fr.) Gray.

Oncol Lett 2019 Feb 28;17(2):2507-2515. Epub 2018 Dec 28.

Key Laboratory of Southwest China Wildlife Resources Conservation, College of Life Sciences, China West Normal University, Nanchong, Sichuan 637009, P.R. China.

The fundamental mechanisms underlying the preventional and therapeutic effects of polysaccharides from fungi, including the immunostimulatory, antiviral and antitumor effects, are considered to occur through the modulation and stimulation of the macrophage and complement system. LDG-A, a novel polysaccharide from (L. ex Fr. Read More

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http://dx.doi.org/10.3892/ol.2018.9879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350191PMC
February 2019

miR-16 regulates proliferation and apoptosis of pituitary adenoma cells by inhibiting HMGA2.

Oncol Lett 2019 Feb 28;17(2):2491-2497. Epub 2018 Dec 28.

Department of Neurology, Hongqi Hospital, MuDanJiang Medical University, Mudanjiang, Heilongjiang 157000, P.R. China.

Previous studies have revealed that elevated expression of high mobility group A2 (HMGA2) is closely associated with the occurrence of pituitary adenomas (PAs). The expression of microRNA (miR)-16 is deregulated in PA tissues. Bioinformatics analysis has demonstrated that there is a complementary region between seed region of miR-16 and 3'-untranslated region (3'-UTR) of HMGA2 gene. Read More

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http://dx.doi.org/10.3892/ol.2018.9872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350189PMC
February 2019

Expression of coxsackie and adenovirus receptor is correlated with inferior prognosis in liver cancer patients.

Oncol Lett 2019 Feb 24;17(2):2485-2490. Epub 2018 Dec 24.

Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.

The coxsackie and adenovirus receptor (CAR), a tumor suppressor, is vital for the effectiveness of therapies which utilize the adenovirus. However, studies on CAR expression in hepatocellular carcinoma (HCC) are conflicting and its clinical significance requires exploration. In this study, immunohistochemistry has been carried out on tissue microarrays consisting of 198 pairs of HCC and neighboring healthy tissue specimens from Chinese Han patients to evaluate CAR expression. Read More

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http://dx.doi.org/10.3892/ol.2018.9868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350183PMC
February 2019

Synchronous primary sigmoid colon cancer and primary thyroid cancer followed by a malignant tumor of the kidney: Case report of multiple primary cancer and review of the literature.

Oncol Lett 2019 Feb 24;17(2):2479-2484. Epub 2018 Dec 24.

Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.

Multiple primary cancer (MPC) is relatively rare. With the development of diagnostic and anti-cancer therapeutic techniques, the incidence of MPC is rising annually. However, the incidence of triple or quadruple cancers in a single patient remains low. Read More

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http://dx.doi.org/10.3892/ol.2018.9867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350185PMC
February 2019

The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells.

Oncol Lett 2019 Feb 28;17(2):2473-2478. Epub 2018 Dec 28.

Department of Hepatic-Biliary-Pancreatic Center, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China.

Fat mass and obesity-associated (FTO) protein has been identified as a critical demethylase in regulating cellular mRNA stability by removing N-methyladenosine (mA) residues in mRNA. Even though the role of FTO in body energy metabolism has been well established, its role in cancer cell homeostasis remains unclear. In the present study, by using RNA interference, it was indicated that FTO is required for pancreatic cancer cell proliferation. Read More

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http://dx.doi.org/10.3892/ol.2018.9873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350187PMC
February 2019
1 Read

Metformin attenuates hypoxia-induced resistance to cisplatin in the HepG2 cell line.

Oncol Lett 2019 Feb 24;17(2):2431-2440. Epub 2018 Dec 24.

Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.

Hepatoblastoma is the most commonly occurring liver tumor in children. Preoperative chemotherapy and surgery have improved treatment outcomes; however, further improvements are required in the treatment of advanced cases. Recently, the efficacy of transarterial chemoembolization (TACE) has garnered attention. Read More

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http://dx.doi.org/10.3892/ol.2018.9869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350205PMC
February 2019

MicroRNA-372 functions as a tumor suppressor in cell invasion, migration and epithelial-mesenchymal transition by targeting in renal cell carcinoma.

Oncol Lett 2019 Feb 28;17(2):2400-2408. Epub 2018 Dec 28.

Department of Urology, Beijing Ditan Hospital Capital Medical University, Capital Medical University, Beijing 100015, P.R. China.

In recent years, renal cell carcinoma (RCC) has exhibited an increasing incidence and mortality rate worldwide. Accumulating evidence has identified that microRNAs (miRNAs) function as negative or positive regulators of many malignant tumors; however, the roles of miR-372 in RCC remain unclear. The focus of the present study was the functions of miR-372 in RCC metastasis and EMT. Read More

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http://dx.doi.org/10.3892/ol.2018.9871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350190PMC
February 2019
2 Reads

Prognostic value of serum IL-8 and IL-10 in patients with ovarian cancer undergoing chemotherapy.

Oncol Lett 2019 Feb 18;17(2):2365-2369. Epub 2018 Dec 18.

Department of Gynaecology, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China.

Prognostic value of serum interleukin-8 (IL-8) and interleukin-10 (IL-10) in patients with ovarian cancer undergoing chemotherapy was evaluated. The clinical data of ovarian tumor patients in Yidu Central Hospital of Weifang treated from January 2012 to December 2014 was retrospectively analyzed, 92 cases of which were malignant group, 64 cases were benign group, and 58 healthy subjects were selected as control group. Serum expression levels of IL-8 and IL-10 of the three groups were detected by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.3892/ol.2018.9842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350276PMC
February 2019

Knockdown of SNHG12 suppresses tumor metastasis and epithelial-mesenchymal transition via the Slug/ZEB2 signaling pathway by targeting miR-218 in NSCLC.

Oncol Lett 2019 Feb 28;17(2):2356-2364. Epub 2018 Dec 28.

Clinical Laboratory of Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.

Non-small cell lung cancer (NSCLC) is a type of lung cancer which has a high mortality and low survival rate. Previous studies have revealed that long non-coding RNAs participate in tumorigenesis and metastasis in NSCLC. In the present study, the function of small nucleolar RNA host gene 12 (SNHG12) was investigated in NSCLC. Read More

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http://dx.doi.org/10.3892/ol.2018.9880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351734PMC
February 2019
1 Read

A potential novel therapy for FGFR1-amplified pancreatic cancer with bone metastasis, screened by next-generation sequencing and a patient-derived xenograft model.

Oncol Lett 2019 Feb 28;17(2):2303-2307. Epub 2018 Dec 28.

Department of Colorectal Surgery, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China.

Effective therapies are limited for pancreatic cancer, particularly for those with distant tumour metastases. Therefore, more individualised drug screening is urgently required. Next-generation sequencing (NGS) is a powerful tool to investigate the genomic landscape of patients and the mechanism of drug response, which may provide a broader vision for potential clinical drug screening. Read More

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http://dx.doi.org/10.3892/ol.2018.9876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350188PMC
February 2019
1 Read

Effects of compound Kushen injection on pathology and angiogenesis of tumor tissues.

Oncol Lett 2019 Feb 21;17(2):2278-2282. Epub 2018 Dec 21.

Institute of Pharmacology, Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China.

Effects of compound Kushen injection on pathology and angiogenesis of tumor tissues were investigated. Forty nude mice were used to establish the liver cancer model of nude mice, and were divided into model group (n=10), low-dose compound Kushen injection group (n=10), medium-dose compound Kushen injection group (n=10) and high-dose compound Kushen injection group (n=10). When the tumor volume reached 0. Read More

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http://dx.doi.org/10.3892/ol.2018.9861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351733PMC
February 2019
1 Read

Emerging role of long non-coding RNA MALAT1 in predicting clinical outcomes of patients with digestive system malignancies: A meta-analysis.

Oncol Lett 2019 Feb 28;17(2):2159-2170. Epub 2018 Dec 28.

Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China.

Digestive system malignancies are the most common cancer types worldwide and exhibit an extremely low overall 5-year survival rate. Therefore, clinically applicable biomarkers for predicting clinical outcome are urgently required. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is abnormally expressed in several cancer types. Read More

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http://dx.doi.org/10.3892/ol.2018.9875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350192PMC
February 2019
2 Reads

Distribution of cancer stem cells in two human brain gliomas.

Oncol Lett 2019 Feb 12;17(2):2123-2130. Epub 2018 Dec 12.

Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

There is compelling evidence that brain tumors, particularly glioblastoma multiforme (GBM), harbor a small population of cancer stem cells (CSCs). These CSCs have the ability to undergo self-renewal, initiate tumors , and are resistant to chemotherapy and radiation therapy. The present study determined the spatial distribution of CSCs within the donated brains of two deceased patients affected by glioblastoma multiforme. Read More

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http://dx.doi.org/10.3892/ol.2018.9824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351732PMC
February 2019

DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.

Oncol Lett 2019 Feb 28;17(2):2107-2116. Epub 2018 Dec 28.

Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.

Deleted in liver cancer 2 (DLC2) is a tumor suppressor, associated with various types of cancer. The aim of the present study was to analyze the expression of DLC2 in breast cancer, its clinical significance and its effect on breast cancer cell behavior. The expression of DLC2 was evaluated by immunohistochemistry in 131 cases of breast cancer. Read More

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http://dx.doi.org/10.3892/ol.2018.9874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350186PMC
February 2019
1 Read

Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report.

Oncol Lett 2019 Feb 28;17(2):2069-2074. Epub 2018 Dec 28.

Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China.

Hilar cholangiocarcinoma is a highly malignant tumor and is currently treated by surgical resection or liver transplantation; however, these treatments result in poor patient prognosis accompanied with high recurrence and low patient mortality rates. Neoadjuvant therapy with liver transplantation is a novel treatment that exhibits promising clinical application, with a reported 5-year survival rate of 82%. However, transplantation centers conducting research into this treatment are limited due to its length and complexity. Read More

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http://dx.doi.org/10.3892/ol.2018.9878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350202PMC
February 2019
2 Reads

Lost expression of cell adhesion molecule 1 is associated with bladder cancer progression and recurrence and its overexpression inhibited tumor cell malignant behaviors.

Oncol Lett 2019 Feb 18;17(2):2047-2056. Epub 2018 Dec 18.

Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China.

Cell adhesion molecule 1 (CADM1) regulates cell-cell adhesion and an altered expression level is associated with tumorigenesis and progression. The present study assessed CADM1 expression level in 84 bladder tissues to investigate the association with clinicopathological parameters from bladder cancer patients and then investigated the effects of CADM1 overexpression on T24 bladder cancer cells . The results demonstrated that expression level of CADM1 protein was significantly reduced in bladder cancer tissues (0. Read More

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http://dx.doi.org/10.3892/ol.2018.9845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350208PMC
February 2019
2 Reads

Changes in renal function following nedaplatin-containing chemotherapy in patients with urothelial carcinoma unfit for cisplatin.

Oncol Lett 2019 Feb 20;17(2):2551-2556. Epub 2018 Dec 20.

Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.

The present study evaluated the impact of nedaplatin-containing chemotherapy on renal function in 35 patients with urothelial carcinoma (UC) between 2001 and 2014 who were unfit for cisplatin treatment. As comparative controls, the present study also examined 35 patients with the same disease who underwent cisplatin-containing chemotherapy during the same period. The changes in the estimated glomerular filtration rate (eGFR) prior to and following the administration of nedaplatin during each cycle of chemotherapy was investigated. Read More

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http://dx.doi.org/10.3892/ol.2018.9859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341835PMC
February 2019

Epigenetic treatment-mediated modulation of PD-L1 predicts potential therapy resistance over response markers in myeloid malignancies: A molecular mechanism involving effectors of PD-L1 reverse signaling.

Oncol Lett 2019 Feb 17;17(2):2543-2550. Epub 2018 Dec 17.

Department of Medicine, Eastern Health Clinical School, Monash University, Melbourne, Victoria 3128, Australia.

Recent evidence suggests an association exists between resistance to epigenetic therapy (EGT) and the expression of programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) in myeloid malignancies. Biomarkers are required to predict resistance to EGT in myeloid malignancies, which together with the delineation of associated molecular mechanisms, may provide additional understanding for novel treatment strategies when investigating resistance to EGT. The present study aimed to investigate the effects of EGT on the expression of PD-1, PD-L1 and orphan nuclear receptor NUR77 with clinical responses in patients with myeloid malignancies. Read More

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http://dx.doi.org/10.3892/ol.2018.9841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341830PMC
February 2019
1 Read

Differences in colorectal cancer surveillance epidemiology and screening in the WHO European Region.

Oncol Lett 2019 Feb 19;17(2):2531-2542. Epub 2018 Dec 19.

Local Health Unit 4, Teramo I-64100, Italy.

The aim of this study was to describe the Colorectal Cancer (CRC) burden and prevention actions in 53 countries of the World Health Organization (WHO) European Region (ER). Multiple correspondence analysis was applied to examine the association among the following variables: Measures of occurrence; type of screening programme; existence of cancer registries; data quality and; and gross national income (GNI) level. The study demonstrated clear differences according to GNI: low-middle income (LMI) countries show low mortality rates and unorganized screening programme; upper-middle income (UMI) countries show no test offered, incomplete or absent data mortality, and low quality of the method used to estimate incidence and mortality rates; high income (HI) countries show high mortality rates, test offered (FOBT and colonoscopy), the existence of a national registry, screening population-based, insurance of payment policy, and high quality of the method used to estimate incidence and mortality rates. Read More

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http://dx.doi.org/10.3892/ol.2018.9851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341797PMC
February 2019
1 Read

Metformin selectively targets 4T1 tumorspheres and enhances the antitumor effects of doxorubicin by downregulating the AKT and STAT3 signaling pathways.

Oncol Lett 2019 Feb 12;17(2):2523-2530. Epub 2018 Dec 12.

Department of Pharmacology and Intractable Disease Research Center, School of Medicine, Dongguk University, Gyeongju, Gyeongsangbuk-do 380660, Republic of Korea.

Recent studies have reported that metformin (Met), the first-line medication for the treatment of type 2 diabetes, exhibited anticancer and chemoprotective effects in diverse cancer cells. In this study, we investigated the effects of Met on the drug-resistance of 4T1 murine breast cancer tumorspheres (TS) and the mechanism responsible for its drug-resistance. 4T1 TS exhibited accumulations of cells at the G/G phase compared with cells in monolayer culture, which suggested the majority of cells in TS were quiescent. Read More

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http://dx.doi.org/10.3892/ol.2018.9827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341857PMC
February 2019

Nonylphenol promotes the proliferation of colorectal cancer COLO205 cells by upregulating the expression of protein kinase C ζ.

Oncol Lett 2019 Feb 18;17(2):2498-2506. Epub 2018 Dec 18.

School of Public Health, Zunyi Medical College, Zunyi, Guizhou 563003, P.R. China.

Previous studies have indicated the potential role of estrogen in the development and prognosis of colorectal cancer (CRC). Nonylpheno (NP) is an endocrine-disrupting chemical, which may influence the development of estrogen-dependent types of cancer. However, the molecular mechanism of NP in the development of CRCs remains unclear. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9846
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http://dx.doi.org/10.3892/ol.2018.9846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341561PMC
February 2019
3 Reads

WZY-321, a novel evodiamine analog, inhibits glioma cell growth in an autophagy-associated manner.

Oncol Lett 2019 Feb 18;17(2):2465-2472. Epub 2018 Dec 18.

Department of Ear-Nose-Throat, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, P.R. China.

Glioblastoma is one of the most aggressive types of brain tumor. The median survival rate of patients with glioblastoma (World Health Organization grade IV) is <15 months. Therefore, there is an urgent requirement for the development of novel and efficient therapeutic agents against glioma. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9847
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http://dx.doi.org/10.3892/ol.2018.9847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341813PMC
February 2019
5 Reads

Long non-coding RNA LOC541471: A novel prognostic biomarker for head and neck squamous cell carcinoma.

Oncol Lett 2019 Feb 14;17(2):2457-2464. Epub 2018 Dec 14.

Department of Radiation Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210000, P.R. China.

Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer. Early detection and management of HNSCC may prevent progression of the disease. Long non-coding RNAs (lncRNAs) may serve as prognostic biomarkers for various cancer types. Read More

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http://dx.doi.org/10.3892/ol.2018.9831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341588PMC
February 2019

MicroRNA-543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway.

Oncol Lett 2019 Feb 17;17(2):2451-2456. Epub 2018 Dec 17.

Department of Interventional Therapy, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

The aim of the present study was to investigate the function of microRNA-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA-543. When compared with paracarcinoma tissue, microRNA-543 expression in tissue samples from patients with liver cancer was identified to be decreased. Furthermore, overall survival of patients with high microRNA-543 expression was increased compared with patients with low microRNA-543 expression. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9838
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http://dx.doi.org/10.3892/ol.2018.9838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341803PMC
February 2019
3 Reads

Effects of Beclin 1 overexpression on aggressive phenotypes of colon cancer cells.

Oncol Lett 2019 Feb 10;17(2):2441-2450. Epub 2018 Dec 10.

Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning 110001, P.R. China.

Beclin 1 is involved in autophagy, differentiation, apoptosis and cancer progression, and functions as a haploinsufficient tumor suppressor gene. The aim of the present study was to elucidate the function of Beclin 1 in colon cancer. A Beclin 1-expressing plasmid was transfected into HCT-15 and HCT-116 cells, and the phenotypes and associated molecules were determined. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9817
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http://dx.doi.org/10.3892/ol.2018.9817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341844PMC
February 2019
2 Reads

Efficacy of cytokine-induced killer cells targeting CD40 and GITR.

Oncol Lett 2019 Feb 18;17(2):2425-2430. Epub 2018 Dec 18.

Department of Integrated Oncology, CIO Bonn, University Hospital Bonn, D-53105 Bonn, Germany.

Since the publication of a novel protocol in 1991, cytokine-induced killer (CIK) cells have shown promising results in the treatment against neoplastic diseases. Despite ongoing preclinical and clinical studies, CIK cell treatment in the context of human monoclonal antibodies targeting tumor-necrosis factor receptors remains overlooked. The present study investigated whether a combination of CIK cells with human monoclonal antibody anti-CD40 and anti-Glucocorticoid-induced TNF-related protein (GITR) would lead to further cytotoxicity against tumor cells expressing CD40 and GITR ligand (L). Read More

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http://dx.doi.org/10.3892/ol.2018.9849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341903PMC
February 2019
1 Read

Clinical significance of melanoma cell adhesion molecule CD146 and VEGFA expression in epithelial ovarian cancer.

Oncol Lett 2019 Feb 17;17(2):2418-2424. Epub 2018 Dec 17.

Department of Gynecology and Obstetrics, Cancer Hospital Affiliated to Xinjiang Medical University, Wulumuqi, Xinjiang 830011, P.R. China.

Ovarian cancer is the fifth most common type of cancer in females; however, its asymptomatic progression and the lack of an efficient screening strategy leads to late diagnosis. The present study aimed to investigate the expression levels of cluster of differentiation (CD)146 and vascular endothelial growth factor A (VEGFA) in epithelial ovarian cancer, and their clinical significance. A total of 52 ovarian samples were tested, of which 22 were from patients with epithelial ovarian cancer and 30 were from non-cancer patients. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9840
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http://dx.doi.org/10.3892/ol.2018.9840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341705PMC
February 2019
4 Reads

Effect of fibroblast co-culture on the proliferation, viability and drug response of colon cancer cells.

Oncol Lett 2019 Feb 14;17(2):2409-2417. Epub 2018 Dec 14.

Innovative Target Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.

Interactions between cancer cells and the surrounding fibroblasts serve an important role in cancer proliferation. Colon cancer co-culture model with colon fibroblasts and two metastatic models with lung and skin fibroblasts were established, and the co-culture effects on colon cancer cell proliferation, apoptosis and drug response were evaluated. Co-culture with CCD-18Co and BJ reduces SW480 cell proliferation by 4. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9836
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http://dx.doi.org/10.3892/ol.2018.9836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341796PMC
February 2019
6 Reads

Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer.

Oncol Lett 2019 Feb 11;17(2):2393-2399. Epub 2018 Dec 11.

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874-0838, Japan.

The () gene, which encodes an actin bundling protein known to inhibit cofilin-mediated depolymerization of actin fiber, has been previously reported to serve an important role in the epithelial-mesenchymal transition (EMT) in cancer. The aim of the present study was to determine the clinical significance of and its role in regulating EMT, as well as in promoting cell invasion and migration in gastric cancer. The expression of plastin3 mRNA was measured in 163 resected gastric cancer specimens, in order to determine the clinicopathological significance. Read More

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http://dx.doi.org/10.3892/ol.2018.9819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341793PMC
February 2019

Effects of respiratory motion on volumetric and positional difference of GTV in lung cancer based on 3DCT and 4DCT scanning.

Oncol Lett 2019 Feb 18;17(2):2388-2392. Epub 2018 Dec 18.

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong 250117, P.R. China.

Differences in gross target volume (GTV) and central point positions among moving lung cancer models constructed by CT scanning at different frequencies were compared, in order to explore the effect of different respiratory frequencies on the GTV constructions in moving lung tumors. Eight models in different shapes and sizes were established to stimulate lung tumors. The three-dimensional computed tomography (3DCT) and four-dimensional computed tomography (4DCT) scanning were performed at 10, 15 and 20 times/min in different models. Read More

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http://dx.doi.org/10.3892/ol.2018.9844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341872PMC
February 2019

Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma.

Oncol Lett 2019 Feb 21;17(2):2377-2387. Epub 2018 Dec 21.

Translational Medicine Center, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.

Oral tongue squamous cell carcinoma (OTSCC) is the most common type of oral cancer. Despite advances in knowledge regarding the genome-scale gene expression pattern of oral cancer, the molecular portrait of OTSCC biology has remained unclear over the last few decades. Furthermore, studies concerning OTSCC gene-expression profiles are limited or inconsistent owing to tissue heterogeneity in single-cohort studies. Read More

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http://dx.doi.org/10.3892/ol.2018.9866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341834PMC
February 2019

ALK-G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report.

Oncol Lett 2019 Feb 21;17(2):2370-2376. Epub 2018 Dec 21.

Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.

Epithelioid inflammatory myofibroblastic sarcoma (EIMS), a specific subtype of inflammatory myofibroblastic tumors (IMT), is a relatively rare malignant mesenchymal tumor with clinical features of positive anaplastic lymphoma kinase (ALK), high invasiveness, treatment resistance and poor prognosis. Therefore, ALK inhibitors represent specific effective drugs for patients with this type of tumor. However, acquired resistance remains inevitable without a clear mechanism of action and therapeutic strategy to counteract this. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9865
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http://dx.doi.org/10.3892/ol.2018.9865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341694PMC
February 2019
6 Reads

Systematic tracking of altered modules identifies the key biomarkers involved in chronic lymphocytic leukemia.

Oncol Lett 2019 Feb 7;17(2):2351-2355. Epub 2018 Dec 7.

Department of Laboratory Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.

Key genes in chronic lymphocytic leukemia (CLL) were investigated through systematically tracking the dysregulated modules from protein-protein interaction (PPI) networks. Microarray data of normal subjects and CLL patients recruited from ArrayExpress database were applied to extract differentially expressed genes (DEGs). Additionally, we re-weighted the PPI network of normal and CLL conditions by means of Pearsons correlation coefficient (PCC). Read More

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http://dx.doi.org/10.3892/ol.2018.9812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341787PMC
February 2019

Comparison of laryngeal mask airway and endotracheal intubation in gynecological cancer operation.

Oncol Lett 2019 Feb 7;17(2):2344-2350. Epub 2018 Dec 7.

Department of Anesthesia, Jiangsu Cancer Hospital, Nanjing, Jiangsu 210009, P.R. China.

Endotracheal intubation (ETI) and laryngeal mask airway (LMA) in terms of hemodynamics and reaction were compared. A total of 54 general anesthesia patients were randomized into two groups with 27 cases in each group. Acceleration index (ACI), cardiac index (CI), cardiac output (CO), left cardiac work (LCW), systemic circulation resistance (SVR), mean arterial pressure (MAP), heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded at 12 time-points: before surgery (T0), start effect (T1), lost consciousness (T2), before ETI or LMA (T3), 1 min (T4), 3 min (T5), 5 min (T6) after ETI or LMA, the beginning of surgery (T7), 30 min (T8), 1 hour (T9) after surgery, the end of surgery (T10) and extubation (T11). Read More

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http://dx.doi.org/10.3892/ol.2018.9813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341801PMC
February 2019

Tumor microenvironment classification based on T-cell infiltration and PD-L1 in patients with mismatch repair-proficient and -deficient colorectal cancer.

Oncol Lett 2019 Feb 12;17(2):2335-2343. Epub 2018 Dec 12.

State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.

The classification of tumor microenvironments according to the presence or absence of tumor infiltrating lymphocytes (TILs) and programmed death ligand-1 (PD-L1) expression has been used to predict the efficacy of immune checkpoint inhibitor antibodies in several cancer types, not including colorectal cancer (CRC). The current study investigated the TIL/PD-L1 status of patients with CRC, particularly patients who presented as mismatch repair-proficient (pMMR) and mismatch repair-deficient (dMMR). A total of 243 patients with CRC were enrolled and defined as pMMR (121 patients) or dMMR (122 patients). Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9826
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http://dx.doi.org/10.3892/ol.2018.9826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341814PMC
February 2019
3 Reads
0.987 Impact Factor

The tumor suppressor OVCA1 is a short half-life protein degraded by the ubiquitin-proteasome pathway.

Oncol Lett 2019 Feb 19;17(2):2328-2334. Epub 2018 Dec 19.

College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.

Ovarian cancer gene 1 () is a tumor suppressor associated with ovarian cancer, which is involved in cell proliferation regulation, embryonic development and tumorigenesis. Loss of heterozygosity in the gene occurs in 50-86% of cases of ovarian cancer; however, the physiological and biochemical functions of OVCA1 are not yet clear. In the present study, the stability and degradation of OVCA1 were investigated in A2780, Hela and 293 cells. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9852
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http://dx.doi.org/10.3892/ol.2018.9852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341780PMC
February 2019
7 Reads
0.987 Impact Factor

MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma.

Oncol Lett 2019 Feb 18;17(2):2317-2327. Epub 2018 Dec 18.

Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.

MicroRNAs (miRNAs) serve an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR-197-3p has been reported in various human malignancies. However, the role of miR-197-3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9848
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http://dx.doi.org/10.3892/ol.2018.9848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341871PMC
February 2019
2 Reads

Immunohistochemical analysis of matrix metalloproteinase-9 predicts papillary thyroid carcinoma prognosis.

Oncol Lett 2019 Feb 19;17(2):2308-2316. Epub 2018 Dec 19.

Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

The present study aimed to explore the association between immunohistochemical matrix metalloproteinase-9 (MMP-9) expression and the clinicopathological characteristics of patients with papillary thyroid carcinoma (PTC), and to determine whether it may be used as a diagnostic or prognostic tool for PTC. Immunohistochemical staining of MMP-9 was performed in thyroid tissues obtained from 112 patients with PTC and 42 subjects with benign thyroid nodules (BTNs). The receiver operating characteristic curve was used to evaluate the legitimacy of MMP-9 as a diagnostic tool for PTC, and a predictor for structurally persistent/recurrent disease (SPRD) and disease status. Read More

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http://dx.doi.org/10.3892/ol.2018.9850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341782PMC
February 2019
2 Reads
0.987 Impact Factor

Correlation of SOX9 and NM23 genes with the incidence and prognosis of prostate cancer.

Oncol Lett 2019 Feb 12;17(2):2296-2302. Epub 2018 Dec 12.

Department of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China.

Correlation of sex determining region Y-box (SOX)9 and NM23 genes with the incidence and prognosis of prostate cancer (PC) was investigated. SOX9-small interfering ribonucleic acid (siRNA) and NM23-siRNA were constructed and transfected into PC-3 cells. The expression levels of SOX9 and NM23 messenger RNAs (mRNAs) and proteins in PC-3 cells were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9828
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http://dx.doi.org/10.3892/ol.2018.9828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341668PMC
February 2019
4 Reads

Identification of imatinib-resistant long non-coding RNAs in gastrointestinal stromal tumors.

Oncol Lett 2019 Feb 11;17(2):2283-2295. Epub 2018 Dec 11.

Department of Radiotherapy and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Long non-coding RNAs (lncRNAs) are an abundant RNA species that belong to the competing endogenous RNA network, which serves a critical role in the development, diagnosis and progression of diseases. Using chip technology, the current study analyzed the expression of lncRNAs in paired normal gastric tissues, primary gastrointestinal stromal tumor (GIST) tissues and GIST tissues resistant to imatinib mesylate. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to predict potential tumorigenesis and drug resistance mechanisms. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9821
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http://dx.doi.org/10.3892/ol.2018.9821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341907PMC
February 2019
2 Reads

Expression of miR-21 and miR-138 in colon cancer and its effect on cell proliferation and prognosis.

Oncol Lett 2019 Feb 21;17(2):2271-2277. Epub 2018 Dec 21.

Department of Oncology Center, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China.

Effect of miR-21 and miR-138 on the proliferation of colon cancer cells and their association with prognosis were investigated. Expression levels of miR-21 and miR-138 in colorectal cancer and normal adjacent tissues were compared. Differential expression of miR-21 and miR-138 in colon cancer tissues with different clinicopathological features were analyzed. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9864
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http://dx.doi.org/10.3892/ol.2018.9864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341732PMC
February 2019
6 Reads

Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells.

Oncol Lett 2019 Feb 20;17(2):2266-2270. Epub 2018 Dec 20.

Department of Medical Oncology, The Second Medical Centre, Chinese PLA General Hospital, Beijing 100853, P.R. China.

The role of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway in the proliferation and apoptosis of human colon cancer cells was studied. The transduction process of ERK/MAPK signaling pathway was inhibited using methyl ethyl ketone (MEK) inhibitor U0126. Promoting effect of hepatocyte growth factor (HGF) on proliferation of human colon cancer cells was detected via Cell Counting Kit 8 (CCK8), the cycle and apoptosis of human colon cancer cells were detected via flow cytometry, and the migration of human colon cancer cells was detected via wound healing assay. Read More

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http://dx.doi.org/10.3892/ol.2018.9857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341783PMC
February 2019

Oncogenic miR-744 promotes prostate cancer growth through direct targeting of LKB1.

Oncol Lett 2019 Feb 11;17(2):2257-2265. Epub 2018 Dec 11.

Department of Urology, China and Japan Union Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.

Prostate cancer (PCa) is one of the most common malignancies worldwide, and with a limited number of treatments for this type of cancer, its incidence is rapidly increasing. Patients presenting with PCa are likely to experience disease recurrence, which represents a considerable clinical challenge. MicroRNAs (miRNAs) have been widely characterized as a critical regulator in a number of types of cancer, including PCa. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9822
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http://dx.doi.org/10.3892/ol.2018.9822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341651PMC
February 2019
3 Reads

Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters.

Oncol Lett 2019 Feb 20;17(2):2244-2256. Epub 2018 Dec 20.

Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Lung cancer is one of the leading causes of cancer-associated mortality. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Furthermore, these parameters are also associated with tumor development and metastasis. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9858
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http://dx.doi.org/10.3892/ol.2018.9858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341870PMC
February 2019
4 Reads
0.987 Impact Factor

MicroRNA-155 affects oxidative damage through regulating autophagy in endothelial cells.

Oncol Lett 2019 Feb 21;17(2):2237-2243. Epub 2018 Dec 21.

Department of Geriatrics, Kunming General Hospital, Kunming, Yunnan 650032, P.R. China.

MicroRNA-155 (miRNA-155) is a typical multifunctional miRNA, which serves a crucial role in the regulation of numerous vessel cells. However, its effects on dysfunctional endothelial cells have not been completely elucidated. In order to investigate the signaling pathway of miRNA-155-induced cell injury, HO was used to establish an oxidative stress cell model, and miR-155 was transfected into HO-treated cells. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9860
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http://dx.doi.org/10.3892/ol.2018.9860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341854PMC
February 2019
8 Reads

Identification of potential biomarkers of lung adenocarcinoma brain metastases via microarray analysis of cDNA expression profiles.

Oncol Lett 2019 Feb 14;17(2):2228-2236. Epub 2018 Dec 14.

Department of Neurosurgery, Peking University Ninth School of Clinical Medicine, Beijing 100038, P.R. China.

Brain metastases originating from lung adenocarcinoma (LAD) occur frequently. The aim of the current study was to assess potential biomarkers for the prognosis of lung adenocarcinoma brain metastasis (LAD-BM) through the analysis of gene expression microarrays. The current study downloaded two gene expression datasets, GSE14108 and GSE10245, from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.3892/ol.2018.9829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341808PMC
February 2019

miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5.

Oncol Lett 2019 Feb 18;17(2):2221-2227. Epub 2018 Dec 18.

Department of Obstetrics, People's Hospital of Chengyang, Qingdao, Shandong 266001, P.R. China.

Previous studies have reported that microRNAs regulate gene expression and transcription. miR-21 have been identified to play a role in many types of cancer. KLF5 functions as a tumor inhibitor in certain cancers. Read More

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http://dx.doi.org/10.3892/ol.2018.9843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341730PMC
February 2019