3,373,683 results match your criteria Oncology Williston Park N.Y.[Journal]


Eating behaviour and oxytocin in patients with childhood-onset craniopharyngioma and different grades of hypothalamic involvement.

Pediatr Obes 2019 Apr 23:e12527. Epub 2019 Apr 23.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Carl von Ossietzky University, Oldenburg, Germany.

Background: Patients with childhood-onset craniopharyngioma (CP) often suffer from tumour or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.

Objective: In CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC). Read More

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http://dx.doi.org/10.1111/ijpo.12527DOI Listing

Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.

Hematol Oncol 2019 Apr 23. Epub 2019 Apr 23.

University of California Irvine, Irvine, CA, USA.

The 60 American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13 Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on the 4 -5 December 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues which require clarity. Read More

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http://dx.doi.org/10.1002/hon.2622DOI Listing

[Surgical removal of a follicular carcinoma of the thyroid gland in a snakehead (Channa barca, HAMILTON, 1822)].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):125-132. Epub 2019 Apr 23.

Klinik für Vögel, Reptilien, Amphibien und Fische, Justus-Liebig-Universität Gießen.

Inflammatory processes, neoplastic growths or rare dysontogenetic malformations may cause mass formation in the gills of fish. In the present case, a follicular carcinoma of the thyroid gland in a Barca snakehead and its surgical removal are reported, and neoplasms in fish are discussed. Following clinical, radiological, cytological and sonographic examinations, the gill-associated partly cystic mass was incompletely removed surgically. Read More

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http://dx.doi.org/10.1055/a-0858-9573DOI Listing

The Controlling Nutritional Status Score and Postoperative Complication Risk in Gastrointestinal and Hepatopancreatobiliary Surgical Oncology: A Systematic Review and Meta-Analysis.

Ann Nutr Metab 2019 Apr 23;74(4):303-312. Epub 2019 Apr 23.

Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

The controlling nutritional status (CONUT) score is associated with prognosis in gastrointestinal (GI) cancer patients, but the clinical significance of the CONUT score for postoperative short-term outcome remains controversial. The aim of this study was to investigate the impact of the CONUT score on postoperative outcomes in patients with GI and hepatopancreatobiliary (HPB) cancers. We conducted a systematic literature search of Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. Read More

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http://dx.doi.org/10.1159/000500233DOI Listing

The Role of Ancillary Techniques in Pulmonary Cytopathology.

Acta Cytol 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pathology, New York University School of Medicine, New York, New York, USA,

Ancillary techniques play an essential role in pulmonary cytopathology. Immunoperoxidase and special stains are by far the most common ancillary techniques used in cytopathology; however, the role of molecular diagnosis is growing, especially in the fields of pulmonary oncology and infectious disease. In this article, we review the uses of ancillary techniques in lung tumor diagnosis, lung tumor classification, predictive marker determination, primary versus metastasis differential diagnosis, and infectious organism detection. Read More

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http://dx.doi.org/10.1159/000498889DOI Listing

Location of Death and End-of-Life Characteristics of Young Adults with Cancer Treated at a Pediatric Hospital.

J Adolesc Young Adult Oncol 2019 Apr 23. Epub 2019 Apr 23.

3 Division of Anesthesia, Department of Palliative Care, Cincinnati Children's Hospital, Cincinnati, Ohio.

Location of death (LOD) is an important aspect of end-of-life (EOL) care. Adolescents and young adults (YAs) with pediatric malignancies are increasingly treated in pediatric institutions. YAs, generally defined as 18-39 years old, deserve specific attention because adults have unique developmental and social considerations compared with younger patients. Read More

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http://dx.doi.org/10.1089/jayao.2018.0123DOI Listing

Exploratory analysis of prognostic factors for lenvatinib in radioiodine-refractory differentiated thyroid cancer.

Head Neck 2019 Apr 23. Epub 2019 Apr 23.

Department of Medical Oncology/Hematology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Multitarget kinase inhibitors (m-TKI), including lenvatinib, are now available as treatment options for radioiodine-refractory differentiated thyroid cancer (RR-DTC). However, the optimal timing of treatment initiation with m-TKI in these patients remains to be defined.

Methods: We retrospectively reviewed the clinical records of 30 consecutive patients with RR-DTC. Read More

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http://dx.doi.org/10.1002/hed.25784DOI Listing

Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

IRCCS Foundation, Evaluative Epidemiology Unit, Evaluative Epidemiology Unit, National Cancer Institute, Milan, Italy.

Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32121
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http://dx.doi.org/10.1002/cncr.32121DOI Listing

Oral health related quality of life, oral esthetics and oral function in head and neck cancer patients after oral rehabilitation.

J Oral Rehabil 2019 Apr 23. Epub 2019 Apr 23.

Section of Oral Rehabilitation, Department of Odontology, University of Copenhagen.

Background: Head and neck cancer (HNC) is diagnosed in more than 500.000 patients every year worldwide with increasing prevalence. Oral rehabilitation is often needed after HNC-treatment to regain oral function, esthetics and oral health related quality of life (OHRQoL). Read More

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http://dx.doi.org/10.1111/joor.12806DOI Listing

Targeting self and neo-epitopes with a modular self-adjuvanting cancer vaccine.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Induction of a potent CD4 and CD8 T-cell response against tumor-specific and tumor-associated antigen is critical for eliminating tumor cells. Recent vaccination strategies have been hampered by an inefficacious and low amplitude immune response. Here we describe a self-adjuvanted chimeric protein vaccine platform to address these challenges, characterized by a multidomain construction incorporating (i) a cell penetrating peptide (CPP) allowing internalization of several multiantigenic Major Histocompatibility Complex (MHC)-restricted peptides within (ii) the multiantigenic domain (Mad) and (iii) a TLR2/4 agonist domain (TLRag). Read More

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http://insight.jci.org/articles/view/127305
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http://dx.doi.org/10.1172/jci.insight.127305DOI Listing
April 2019
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Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Preneoplastic lesions carry many of the antigenic targets found in cancer cells but often exhibit prolonged dormancy. Understanding how the host response to premalignancy is maintained and altered during malignant transformation is needed to prevent cancer. In order to understand the immune microenvironment in precursor monoclonal gammopathy of undetermined significance (MGUS) and myeloma, we analyzed bone marrow immune cells from 12 healthy donors and 26 MGUS/myeloma patients by mass cytometry and concurrently profiled transcriptomes of 42,606 single immune cells from these bone marrows. Read More

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http://dx.doi.org/10.1172/jci.insight.127807DOI Listing

Primary Left Atrial Angiosarcoma Presenting as Acute Coronary Syndrome.

Heart Surg Forum 2019 Apr 12;22(2):E162-E164. Epub 2019 Apr 12.

Department of Cardiovascular Diseases, University Hospital Dubrava, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia.

Primary cardiac neoplasms are extremely rare and often overlooked as differential diagnosis. Angiosarcomas are the most common primary malignant neoplasms of the heart often with nonspecific symptoms. We present a 43-year-old woman admitted to our hospital with chest pain and inferoposterolateral myocardial infarction. Read More

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https://journal.hsforum.com/index.php/HSF/article/view/2381
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http://dx.doi.org/10.1532/hsf.2381DOI Listing
April 2019
1 Read

Elevated Swelling-Activated Chloride Current Densities in Hypertrophied Ventricular Myocytes in a Rabbit Heart Failure Model.

Heart Surg Forum 2019 Mar 7;22(2):E107-E111. Epub 2019 Mar 7.

Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: The status of the swelling-activated chloride channel (ICl, swell) during heart failure remains unclear. This study aimed to investigate whether the ICl, swell activity is altered during heart failure and to determine how the ICl, swell influences atrial arrhythmias of the failing heart.

Methods: We established a heart failure rabbit model and analyzed the hemodynamic indicators 8 weeks after myocardial infarction, which include left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVDEP). Read More

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http://dx.doi.org/10.1532/hsf.2255DOI Listing

End-of-Life Costs and Hospice Utilization in Patients with Head and Neck Cancer.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819846072. Epub 2019 Apr 23.

1 Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.

The Quality Oncology Practice Initiative has several metrics related to end-of life (EOL) care, including hospice enrollment ≤3 days, with lower scores signaling better performance. Of privately insured patients with head and neck cancer, 3.5% were enrolled in hospice prior to death and 21. Read More

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http://dx.doi.org/10.1177/0194599819846072DOI Listing

Dignity in life and care: the perspectives of Swedish patients in a palliative care context.

Int J Palliat Nurs 2019 Apr;25(4):193-201

Associate Professor, Research Supervisor, Centre for Research and Development, Uppsala University/Region Gävleborg, Gävle; (affiliated) Faculty of Medicine and Health, School of Health Sciences, Örebro University; and (affiliated) Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Background: How patients preserve their sense of dignity in life is an important area of palliative care that remains to be explored.

Aims: To describe patients' perspectives of what constitutes a dignified life within a palliative care context.

Methods: Twelve palliative care patients were interviewed about their views on living with dignity. Read More

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http://dx.doi.org/10.12968/ijpn.2019.25.4.193DOI Listing

Systematic Review of Validated Quality of Life and Swallow Outcomes after Transoral Robotic Surgery.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844755. Epub 2019 Apr 23.

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: To systematically review the available evidence on the effects of transoral robotic surgery (TORS) on the posttreatment quality of life (QOL) and swallow function of patients with head and neck cancer.

Data Sources: PubMed and Ovid electronic databases were searched from inception to July 6, 2016. Specific database functions were applied to maximize the search. Read More

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http://dx.doi.org/10.1177/0194599819844755DOI Listing

Rethinking Malignancy Risk in Indeterminate Thyroid Nodules with Positive Molecular Studies: Southern California Permanente Experience.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819842859. Epub 2019 Apr 23.

5 Department of Pathology, Southern California Permanente Medical Group, Woodland Hills, California, USA.

Objectives: To recognize that thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS; Bethesda III) have different risks of malignancy based on genetic mutation and to consider molecular testing of nodules with AUS/FLUS to help avoid unnecessary morbidity or cost.

Study Design: Retrospective cohort study.

Setting: Multiple locations within Southern California Permanente Medical Group. Read More

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http://dx.doi.org/10.1177/0194599819842859DOI Listing

Ocular Adverse Events following Use of Immune Checkpoint Inhibitors for Metastatic Malignancies.

Ocul Immunol Inflamm 2019 Apr 23:1-6. Epub 2019 Apr 23.

c Department of Ophthalmology , National Eye Institute , Bethesda , USA.

Purpose: To report the clinical features, severity, and management of ocular immune-related adverse events (irAEs) in the setting of immune checkpoint inhibitor therapy for metastatic malignancies.

Methods: Retrospective chart review at three tertiary ophthalmology clinics. Electronic medical records were reviewed between 2000 and 2017 for patients with new ocular symptoms while undergoing checkpoint inhibition therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2019.1
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http://dx.doi.org/10.1080/09273948.2019.1583347DOI Listing
April 2019
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Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.

J Clin Oncol 2019 Apr 23:JCO1802374. Epub 2019 Apr 23.

16 Monter Cancer Center, Northwell Health, Lake Success, NY, and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

Purpose: SARC024 is a phase II clinical trial of the multikinase inhibitor regorafenib in specific sarcoma subtypes, including advanced osteosarcoma. We hypothesized that regorafenib would improve progression-free survival (PFS) in patients with sarcoma and report the results of the osteosarcoma cohort.

Patients And Methods: This trial enrolled patients with progressive metastatic osteosarcoma with measurable disease by RECIST who had received at least one prior line of therapy. Read More

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http://dx.doi.org/10.1200/JCO.18.02374DOI Listing

BASELINE TSH LEVEL IS ASSOCIATED WITH RISK OF ANTI PD-1 INDUCED THYROID DYSFUNCTION.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Department of Endocrinology and Metabolism, Division of Medicine, Hadassah-Hebrew University Hospital, Jerusalem Israel.

To characterize anti-programmed cell death 1 (PD-1) induced thyroid immune related adverse events (irAEs) in metastatic melanoma patients treated at our institution and to identify risk factors associated with their development. We reviewed the files of 154 patients with metastatic melanoma treated with PD-1 inhibitors at a single institution from November 1, 2011 to February 28, 2017. The association of thyroid irAEs within 120 days post-treatment initiation with age, gender, melanoma characteristics, treatment protocol, and baseline TSH was examined. Read More

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http://dx.doi.org/10.4158/EP-2018-0472DOI Listing

Cytology and the cell block method in diagnostic characterization of canine lymphadenopathy and in the immunophenotyping of nodal lymphoma.

Vet Comp Oncol 2019 Apr 23. Epub 2019 Apr 23.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, 55108, USA.

Minimally invasive techniques used to evaluate canine peripheral lymphadenopathy (PLN), including fine needle aspiration biopsy with cytologic evaluation (FNAB-C) and flow cytometry (FC), have benefits and limitations. The cell block (CB) method is an alternate processing technique in which fine needle aspirate biopsy samples are concentrated, fixed, and embedded in paraffin for routine histologic processing/staining. Utilizing three observers, we determined the diagnostic value of the CB in evaluating canine PLN across six categories (non-diagnostic, reactive, inflammatory/infectious, probable lymphoma, lymphoma, metastatic neoplasia) and correlated findings to immunophenotypic and clonal antigen receptor rearrangement results in canine nodal lymphoma . Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vco.12484
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http://dx.doi.org/10.1111/vco.12484DOI Listing
April 2019
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Extended-spectrum β-lactamase in the rectal flora of patients undergoing transrectal prostate biopsy: a study of the prevalence in a major metropolitan hospital.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Urology, Royal Melbourne Hospital, Parkville, Vic., Australia.

Objectives: To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic antibiotic guidelines in the context of local ESBL prevalence.

Methods: Patients undergoing transrectal ultrasonography (TRUS)-guided biopsy at the Royal Melbourne Hospital between January 2012 and July 2016 had rectal swabs taken immediately prior to TRUS with specific cultures to identify the presence of ESBL. Patients were given a prophylactic antibiotic, 500 mg oral ciprofloxacin, 1 h before the TRUS procedure. Read More

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http://dx.doi.org/10.1111/bju.14745DOI Listing

A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: The ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions) to increase moderate to vigorous physical activity (MVPA) and reduce sedentary behavior in breast cancer survivors.

Methods: This randomized controlled trial recruited 83 inactive, postmenopausal women diagnosed with stage I-III breast cancer who had completed primary treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32143
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http://dx.doi.org/10.1002/cncr.32143DOI Listing
April 2019
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Maintenance of physical activity and sedentary behavior change, and physical activity and sedentary behavior change after an abridged intervention: Secondary outcomes from the ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: This brief report examines the maintenance of moderate to vigorous physical activity (MVPA) and sedentary behavior changes approximately 12 weeks after the delivery of the ACTIVATE Trial primary intervention (use of the Garmin Vivofit 2 activity tracker coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions). We also examine the efficacy of an abridged intervention (use of the Garmin Vivofit 2 only) in the waitlist control group.

Methods: A pre-post design was employed to examine the secondary aims of the ACTIVATE Trial (n = 80; mean age = 62 years). Read More

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http://dx.doi.org/10.1002/cncr.32142DOI Listing

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Background: Over 96% of high-grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. Therapeutic strategies to restore and/or reactivate the p53 pathway have been challenging. By contrast, p63, which shares many of the downstream targets and functions of p53, is rarely mutated in cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32053
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http://dx.doi.org/10.1002/cncr.32053DOI Listing
April 2019
1 Read

Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 ( Lu-J591) for metastatic castration-resistant prostate cancer.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.

Background: Prostate cancer is radiosensitive. Prostate-specific membrane antigen (PSMA) is selectively overexpressed on advanced, castration-resistant tumors. Lutetium-177-labeled anti-PSMA monoclonal antibody J591 ( Lu-J591) targets prostate cancer with efficacy and dose-response/toxicity data when delivered as a single dose. Read More

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http://dx.doi.org/10.1002/cncr.32072DOI Listing

A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Epigenetic abnormalities are manifold in all solid tumors and include changes in chromatin configuration and DNA methylation. The authors designed a phase 1 study to evaluate the oral DNA methyltransferase inhibitor CC-486 combined with the histone deacetylase inhibitor romidepsin in advanced solid tumors with dose expansion to further evaluate pharmacodynamics and possible clinical benefit of the recommended phase 2 dose (RP2D).

Methods: This was a phase 1 study with a 3 + 3 dose-escalation design and an expansion phase for patients with virally mediated cancers. Read More

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http://dx.doi.org/10.1002/cncr.32138DOI Listing

The Burden of Breast Cancer Predisposition Variants Across The Age Spectrum Among 10 000 Patients.

J Am Geriatr Soc 2019 Apr 23. Epub 2019 Apr 23.

Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center, Duarte, California.

Background/objectives: Women diagnosed with breast cancer (BC) at an older age are less likely to undergo genetic cancer risk assessment and genetic testing since the guidelines and referrals are biased toward earlier age at diagnosis. Thus, we determined the prevalence and type of pathogenic cancer predisposition variants among women with a history of BC diagnosed at the age of 65 years or older vs younger than 65 years.

Design: Prospective registration cohort. Read More

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http://dx.doi.org/10.1111/jgs.15937DOI Listing

Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Background: The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and neck is controversial. In the current study, the authors evaluated the impact of high-risk HPV status on overall survival (OS) in patients with non-OPX SCC using a large database approach.

Methods: The National Cancer Data Base was queried to identify patients diagnosed from 2004 through 2014 with SCC of the OPX, hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32115
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http://dx.doi.org/10.1002/cncr.32115DOI Listing

The American Joint Committee on Cancer turns 60.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

American Joint Committee on Cancer, Chicago, Illinois.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32159
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http://dx.doi.org/10.1002/cncr.32159DOI Listing
April 2019
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Trends in Sedentary Behavior Among the US Population, 2001-2016.

JAMA 2019 Apr;321(16):1587-1597

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.

Importance: Prolonged sitting, particularly watching television or videos, has been associated with increased risk of multiple diseases and mortality. However, changes in sedentary behaviors over time have not been well described in the United States.

Objective: To evaluate patterns and temporal trends in sedentary behaviors and sociodemographic and lifestyle correlates in the US population. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.3636DOI Listing
April 2019
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Wearable-Based Mobile Health App in Gastric Cancer Patients for Postoperative Physical Activity Monitoring: Focus Group Study.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e11989. Epub 2019 Apr 23.

Department of Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.

Background: Surgical cancer patients often have deteriorated physical activity (PA), which in turn, contributes to poor outcomes and early recurrence of cancer. Mobile health (mHealth) platforms are progressively used for monitoring clinical conditions in medical subjects. Despite prevalent enthusiasm for the use of mHealth, limited studies have applied these platforms to surgical patients who are in much need of care because of acutely significant loss of physical function during the postoperative period. Read More

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http://dx.doi.org/10.2196/11989DOI Listing

Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.

Radiology 2019 Apr 23:182326. Epub 2019 Apr 23.

From the Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, H-118, New York, NY 10065 (J.P.E.); Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, Utah (G.C.F.); Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands (G.J.A., M.d.B.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (M.A.); Division of Vascular and Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.); Department of Radiodiagnostic and Interventional Radiology, University of Lausanne, Lausanne, Switzerland (R.D.); Penn Image-Guided Interventions Laboratory and Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (S.J.H.); Department of Radiology, University of Colorado, Denver, Colo (D.T.J.); Department of Radiology, Ludwig-Maximilian University, Munich, Germany (J.R.); Division of Vascular and Interventional Radiology, Stanford University, Stanford, Calif (D.Y.S.); Division of Interventional Radiology, Mayo Clinic Florida, Jacksonville, Fla (B.B.T.); Center for Interventional Oncology, National Cancer Institute, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (B.J.W.); Department of Radiology, Mayo Clinic, Rochester Minn (D.W.); and Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (S.N.G.).

Interventional oncology is a subspecialty field of interventional radiology that addresses the diagnosis and treatment of cancer and cancer-related problems by using targeted minimally invasive procedures performed with image guidance. Immuno-oncology is an innovative area of cancer research and practice that seeks to help the patient's own immune system fight cancer. Both interventional oncology and immuno-oncology can potentially play a pivotal role in cancer management plans when used alongside medical, surgical, and radiation oncology in the care of cancer patients. Read More

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http://dx.doi.org/10.1148/radiol.2019182326DOI Listing

Equal palliative care for patients with COPD? A nationwide register study.

Ups J Med Sci 2019 Apr 23:1-8. Epub 2019 Apr 23.

g Department of Research and Development , Region Halland , Sweden.

Background: Although chronic obstructive pulmonary disease (COPD) is a life-limiting disease with a significant symptom burden, the patients are more often referred to nursing homes (NH), than to specialist palliative care (SPC) at the end of life (EOL). This study aimed to compare patients with COPD in SPC with those in NH and to compare the care provided.

Methods: A national register study was carried out where the Swedish National Airway Register and the Swedish Register of Palliative Care were merged. Read More

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http://dx.doi.org/10.1080/03009734.2019.1586803DOI Listing

Management of BK-virus infection - Swedish recommendations.

Infect Dis (Lond) 2019 Apr 23:1-6. Epub 2019 Apr 23.

k Department of Infectious Diseases , Karolinska University Hospital , Stockholm , Sweden.

BK-virus (BKV) associated nephropathy (BKVAN) and BKV associated haemorrhagic cystitis (HC) are complications of BKV infection/reactivation in renal and allogeneic haematopoietic stem cell transplantation (HSCT) patients, respectively. The task of how to manage these diseases was given to the chair by the Swedish Reference Group for Antiviral Therapy (RAV). After individual contributions by members of the working group, consensus discussions were held in a meeting on 23 January 2018 arranged by RAV. Read More

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http://dx.doi.org/10.1080/23744235.2019.1595130DOI Listing

Iodine Dose of Administered Contrast Media Affects the Level of Radiation-Induced DNA Damage During Cardiac CT Scans.

AJR Am J Roentgenol 2019 Apr 23:1-6. Epub 2019 Apr 23.

1 Department of Radiology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, Brussels 1090, Belgium.

The purpose of this study is to investigate the contributing effect of contrast media (CM) iodine dose on radiation-induced DNA damage in blood lymphocytes during a cardiac CT scan. The minipigs were exposed 12 times in total to a fixed cardiac CT scan protocol. An unenhanced and two CM injection protocols were considered, the latter with 50% saline diluted (160 mg I/mL) and standard iodixanol. Read More

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http://dx.doi.org/10.2214/AJR.18.20950DOI Listing

Preclinical activity of the antibody-drug conjugate denintuzumab mafodotin (SGN-CD19A) against pediatric acute lymphoblastic leukemia xenografts.

Pediatr Blood Cancer 2019 Apr 23:e27765. Epub 2019 Apr 23.

Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.

Background: Denintuzumab mafodotin (SGN-CD19A) is a CD19-targeting antibody-drug conjugate, comprising a monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin F. Since denintuzumab mafodotin has previously shown activity against B-cell malignancies in early-stage clinical trials, it was of interest to test it against the Pediatric Preclinical Testing Program preclinical models of CD19 pediatric acute lymphoblastic leukemia (ALL).

Procedures: Denintuzumab mafodotin was evaluated against eight B-cell lineage ALL patient-derived xenografts (PDXs), representing B-cell precursor ALL, Ph-like ALL, and mixed-lineage leukemia rearranged infant ALL . Read More

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http://dx.doi.org/10.1002/pbc.27765DOI Listing

Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors.

Diagn Cytopathol 2018 Aug;46(8):663-669

Department of Pathology and Laboratory Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.

Background: Spindle cell neoplasms of the gastrointestinal (GI) tract constitute a wide group of lesions that may raise diagnostic difficulties on hematoxylin-eosin-stained slides. Appropriate endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) technique with sufficient cell block material for immunohistochemistry (IHC) can lead to accurate diagnosis.

Methods: This is a retrospective study of 29 cases obtained from our institution's records over a five-year period (2011-2015). Read More

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http://dx.doi.org/10.1002/dc.23976DOI Listing

Treatment of advanced pediatric renal cell carcinoma.

Pediatr Blood Cancer 2019 Apr 23:e27766. Epub 2019 Apr 23.

Division of Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

Background: Pediatric renal cell carcinoma (pRCC) is the second most common renal malignancy of childhood; however, treatment data for advanced disease is lacking.

Methods: A retrospective analysis of pRCC patients (age < 21 years at diagnosis) treated between 2000 and 2015 at Cincinnati Children's Hospital Medical Center was undertaken, with specific focus on medical therapies, accompanied by a detailed literature review.

Results: Twenty-four patients (median age = 15 years) were identified; 11 were female. Read More

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http://dx.doi.org/10.1002/pbc.27766DOI Listing

Reply to Letter to the Editor "Staging of acute leukemia based on central nervous system involvement alone: Is it appropriate?"

Pediatr Blood Cancer 2019 Apr 23:e27756. Epub 2019 Apr 23.

Cancer Council Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1002/pbc.27756DOI Listing

Spitzoid cutaneous melanoma is associated with favorable clinicopathological factors and outcome.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

Background: Spitzoid melanoma is one of the rare subtypes of melanoma, whose clinical and pathological characteristics have yet to be understood.

Objective: Understanding the histopathologic features and behavior characteristics of Spitzoid cutaneous melanoma.

Methods: A total number of 11 Turkish Caucasian patients with pathologically diagnosed Spitzoid melanoma were analyzed retrospectively. Read More

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http://dx.doi.org/10.1111/jocd.12958DOI Listing

Dark ascites, an ovarian mass and a black dotted peritoneum.

Neth J Med 2019 Apr;77(3):124

Departments of Medical Oncology, University Medical Center Utrecht, the Netherlands.

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Voice and Quality-of-Life Outcomes of Diode Laser for Tis-T1a Glottic Cancer.

Ear Nose Throat J 2019 Apr 23:145561319839868. Epub 2019 Apr 23.

2 Ankara Oncology Education and Research Hospital, Clinic of Otolaryngology, Ankara, Turkey.

The aim of this prospective study was to analyze the voice and quality-of-life outcomes of microscopic diode laser surgery (MDLS). The study was conducted on a series of 46 patients with Tis-T1a glottic carcinoma treated with microscopic endolaryngeal diode laser surgery. Patients were asked to complete the Voice Handicap Index and quality-of-life questionnaires of the European Organization for Research and Treatment of Cancer. Read More

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http://dx.doi.org/10.1177/0145561319839868DOI Listing

Atypical Carcinoid of the Larynx.

Ear Nose Throat J 2019 Apr 23:145561319840157. Epub 2019 Apr 23.

1 Head Neck Oncology Unit, Candiolo Cancer Institute, FPO IRCCS, Candiolo, Turin, Italy.

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http://dx.doi.org/10.1177/0145561319840157DOI Listing

A physicians survey assessing management of pulmonary airway involvement in sickle cell disease.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Division of Respiratory and Sleep Medicine, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

Background: Airway involvement in patients with sickle cell disease (SCD) involves recurrent episodes of acute chest syndrome (ACS), co-existent asthma, lower airway obstruction (LAO), or airway hyper-responsiveness/ bronchodilator response (AHR/BDR). With increased recognition that sickle cell (SC) airway inflammation may be distinct from asthma, our aim was to study regional and individual practices among pediatric pulmonologists and elucidate the patient characteristics that determine the diagnosis of asthma or SC airway inflammation.

Methods: A cross-sectional web-based survey including 6 case scenarios on diagnosis and management of pulmonary manifestations of pediatric SC airway disease was conducted. Read More

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http://dx.doi.org/10.1002/ppul.24289DOI Listing

Preparative isolation and purification of steroidal glycoalkaloid from the ripe berries of Solanum nigrum L. by preparative HPLC-MS and ultra high performance liquid chromatography time-of-flight-MS/MS and its anti-non-small cell lung tumours effects in vitro and in vivo.

J Sep Sci 2019 Apr 23. Epub 2019 Apr 23.

School of Pharmaceutical Sciences, Capital Medical University, Beijing, P. R. China.

Overcoming epidermal growth factor receptor resistance is a critical problem that needs to be solved in clinical practice. Drugs that downregulate the fatty acid synthase-epidermal growth factor receptor will become novel treatments for non-small cell lung cancer. Solanum nigrum, extracted with water at 4°C, shows strong cytotoxic activity and inhibits tumour growth in Lewis tumour bearing-mice in a dose-dependent manner. Read More

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http://dx.doi.org/10.1002/jssc.201801165DOI Listing

Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience.

Pediatr Blood Cancer 2019 Apr 22:e27763. Epub 2019 Apr 22.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Radiation therapy (RT) confers local tumor control and survival advantages in some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) population studies are limited.

Methods: Twenty-eight patients treated with curative-intent RT (median dose, 59.4 Gy; range, 40-76 Gy) at our institution from 1990 to 2017 were retrospectively identified. Read More

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http://dx.doi.org/10.1002/pbc.27763DOI Listing

Utilization of palliative care consultations in pediatric oncology phase I clinical trials.

Pediatr Blood Cancer 2019 Apr 22:e27771. Epub 2019 Apr 22.

Center for Cancer Research, National Cancer Institute, Pediatric Oncology Branch, Bethesda, Maryland.

Pediatric phase I clinical oncology trials represent a unique cohort of patients who have not responded to standard therapies and remain highly vulnerable to treatment toxicity and/or disease burden. Incorporating a palliative care consultation into the care plan for those with relapsed/refractory cancer where chance of cure is limited is generally recommended. A retrospective chart review of pediatric phase I trials revealed that palliative care was consulted in <20% of patients, most often for symptom management. Read More

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http://dx.doi.org/10.1002/pbc.27771DOI Listing

Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole-body computed tomography at diagnosis.

Vet Comp Oncol 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.

This retrospective study aimed to evaluate factors associated with survival and to compare characteristics between tumour localizations in dogs with urinary transitional cell carcinoma (TCC) that underwent whole-body computed tomography (CT) at diagnosis. Dogs with histologically confirmed TCC that received medical therapy between 2010 and 2017 were included; dogs that underwent surgery or radiotherapy for the primary tumour were excluded. According to the CT findings, primary tumour localization (classified into the Bladder, Urethra, and Bladder & Urethra groups), prostate involvement, iliosacral lymphadenomegaly, sternal lymphadenomegaly, and metastasis to the bone and lung were evaluated for survival analysis. Read More

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http://dx.doi.org/10.1111/vco.12483DOI Listing
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