3,311,841 results match your criteria Oncology Williston Park N.Y.[Journal]


miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity.

Cell Physiol Biochem 2018 Dec 6;51(5):2148-2159. Epub 2018 Dec 6.

Minimally Invasive Treatment Center, Fudan University Shanghai Cancer Center, Shanghai,

Background/aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug resistance during the course of treatment. Thus, there is an urgent need to explore novel strategies to improve the efficiency of cancer therapy. The aim of this study was to explore the effect of microRNA-122 (miR-122) on reversing oxaliplatin resistance in CRC. Read More

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December 2018
2 Reads

β-Elemene Inhibits Human Sperm Function by Affecting Sperm Vitality and Intracellular Calcium.

Cell Physiol Biochem 2018 Dec 6;51(5):2019-2029. Epub 2018 Dec 6.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou,

Background/aims: β-Elemene is a bioactive sesquiterpene compound that exhibits a potent anti-tumor effect and is used in various clinical applications. However, little is known about its effect on the male reproductive system. The objective of this study was to investigate the in vitro actions of β-elemene on human sperm function and elucidate the underlying mechanism. Read More

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December 2018
2 Reads

Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.

Cell Physiol Biochem 2018 Dec 6;51(5):2052-2064. Epub 2018 Dec 6.

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background/aims: Alpha-fetoprotein-producing colorectal cancer (AFPP-CRC) is quite rarely seen. This study aimed to elucidate the clinicopathologic characteristics and prognostic factors of AFPP-CRC.

Methods: Among 5,051 colorectal cancer patients receiving surgery in the Fudan University Shanghai Cancer Center from 2006 to 2016, we identified 78 patients with elevated serum level of AFP (> 10 µg/L) preoperatively. Read More

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December 2018

PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer.

Biomed Pharmacother 2018 Dec 3;110:312-318. Epub 2018 Dec 3.

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically been notable worldwide and many attempts have been made to raise the overall survival of CRC patients. Immune response has long been a question of great interest in a wide range of fields such as cancer therapies and anti-tumor immunity through checkpoint inhibitors, specifically anti PD-1/ PD-L1 interaction, is a new line of research for treatment of CRC patients. Following the successful development of anti-PD-1 for melanoma, renal cell carcinoma, and non-small cell lung cancer, several clinical trials have been conducted on monoclonal antibodies (MAbs) against PD-1 in CRC. Read More

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December 2018
6 Reads

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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November 2018
1 Read

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018

EGFR-mutant SCLC exhibits heterogeneous phenotypes and resistance to common antineoplastic drugs.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine, National Taiwan University Hospital, Taiwan. Electronic address:

Introduction: Approximately 5% of patients with EGFR-activating mutations acquire EGFR-TKIs resistance through SCLC transformation. However, the reason for the poor outcome and the molecular basis of EGFR-mutant SCLC that has transformed from adenocarcinoma remain unclear.

Methods: In this study, we established 2 EGFR-mutant SCLC cell lines from lung adenocarcinoma patients after failed EGFR-TKI treatment to investigate their molecular basis and potential therapeutic strategies in the hope of improving patient outcome. Read More

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December 2018
2 Reads

Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering stereotactic fractionated body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL.

Methods: 100 patients with pulmonary lesions were treated with SBRT from 02/2011 to 11/2014 within the prospective, monocenter, phase II STRIPE trial. Read More

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December 2018
1 Read

Targeting indoleamine-2,3-dioxygenase in cancer: Scientific rationale and clinical evidence.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address:

Immunotherapy through immune checkpoint blockers (ICBs) is quickly transforming cancer treatment by improving patients' outcomes. However, innate and acquired resistance to ICBs remain a major challenge in clinical settings. Indoleamine 2,3-dioxygenases (IDOs) are enzymes involved in tryptophan catabolism with a central immunosuppressive function within the tumor microenvironment. Read More

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December 2018
2 Reads

Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.

Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More

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December 2018
2 Reads

Extent of Lymphadenectomy and Postoperative Major Complications Among Women with Endometrial Cancer Treated with Minimally Invasive Surgery.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chicago, IL, USA; Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, IL.

Background: In patients with endometrial cancer sentinel lymphadenectomy is used to accurately prognosticate extent of disease and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensive lymphadenectomy. It is unknown if patients who undergo traditional lymphadenectomy experience major postoperative complications at the same rates as those who undergo sentinel lymphadenectomy or those who do not undergo lymphadenectomy.

Objective: To compare the incidence of major postoperative complications among endometrial cancer patients undergoing total laparoscopic hysterectomy with traditional lymphadenectomy versus sentinel or no lymphadenectomy. Read More

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December 2018
2 Reads

Healthcare Providers' Advice on Lifestyle Modification in the US Population: Results from the National Health and Nutrition Examination Survey 2011-2016.

Am J Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090 Vienna, Austria; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Holy Cross Centre, 2210-2nd Street SW, Box ACB, Calgary, AB, T2S 3C3, Canada; Preventive Oncology & Community Health Sciences, Cumming School of Medicine, University of Calgary, Hospital Drive NW, Calgary, Alberta, Canada. Electronic address:

Objective: Healthcare providers are encouraged to prescribe lifestyle modifications for preventing and managing obesity and associated chronic conditions. However, the pattern of lifestyle advice provision is unknown. We investigate the prevalence of advised lifestyle modification according to weight status and chronic conditions in a US nationally representative sample. Read More

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December 2018

Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision-tree analysis.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Otolaryngology Department, Hospital Clínic, Barcelona, Spain.

Background: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.

Objective: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).

Methods: Local relapse and LC-TLM were evaluated in 1119 patients. Read More

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December 2018

Evaluating risk factors of radiation pneumonitis after stereotactic body radiation therapy in lung tumor: Meta-analysis of 9 observational studies.

PLoS One 2018 6;13(12):e0208637. Epub 2018 Dec 6.

Department of Oncology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Background: In this study, we assessed the association of SBRT (stereotactic body radiotherapy) dose and volume with radiation pneumonitis (RP) risk in lung tumor.

Methods: Relevant articles were identified up to April 2018, using following databases; Medline, EMBASE, Cochrane Library, and China National Knowledge Infrastructure (CNKI). The pooled OR (odds ratio) with 95% CI (confidence interval) data [mean ± SD (standard deviation)] obtained from different studies was analyzed by statistical analysis using a fixed-effects model or a random-effects model when appropriate. Read More

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December 2018
1 Read

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

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December 2018
1 Read

Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study.

PLoS One 2018 6;13(12):e0207707. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members. Read More

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December 2018
1 Read

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions.

PLoS One 2018 6;13(12):e0208273. Epub 2018 Dec 6.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such interactions directly in cells have been lacking. A stringent implementation of proteome-wide Cellular Thermal Shift Assay (CETSA) was developed and applied to key cellular nucleotides, where previously experimentally confirmed protein-nucleotide interactions were well recaptured. Read More

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December 2018
1 Read

Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer.

PLoS One 2018 6;13(12):e0208221. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics. A total of 204 patients with histological diagnosis of endometrial cancer treated from 2004 to 2013 were included. The evaluation of protein expression was assessed by immunohistochemistry. Read More

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December 2018
1 Read

Unexplained cytopenias in an adolescent? You GATA think about it.

J Assoc Genet Technol 2018 ;44(4):135-136

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Objectives: The GATA family of DNA binding proteins consists of six different transcription factors (GATA1-6), each with a diverse biologic function. The transcription factors GATA1-3 function primarily to orchestrate hematopoiesis; however, they have roles in non-hematopoietic cells as well. Much of our current knowledge of the GATA transcription factors has come through observation of disease states with known GATA mutations. Read More

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January 2018

Aggressive Angiomyxoma: A Rare Tumor of Male Pelvic Cavity.

Acta Med Port 2018 Nov 30;31(11):693-696. Epub 2018 Nov 30.

Department of General Surgery. Ankara University School of Medicine. Ankara. Turkey.

Aggressive angiomyxoma is an uncommon, benign, slow-growing, and locally infiltrative soft tissue neoplasm which is located primarily in the genital region and pelviperineal interstitial tissue of female patient in the fourth decade of life. Its occurrence in male patients is even more unusual and commonly appears at a later age. The mainstay of treatment typically involves surgical excision with tumor-free margins, and despite complete resection, local recurrences are common. Read More

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November 2018
1 Read

Molecular Staging of Patients with Colon Cancer. The C-Closer-II Study: A Multicentre Study in Portugal.

Acta Med Port 2018 Nov 30;31(11):661-669. Epub 2018 Nov 30.

Serviço de Cirurgia Geral. Hospital Garcia de Orta. Almada. Portugal.

Introduction: Approximately 20% - 30% of histological lymph node-negative patients with colorectal cancer relapse at five years after surgical treatment. This recurrence is likely due to occult nodal disease undetected by standard histopathological practice which has implications in terms of the clinical management of patients.

Material And Methods: Lymph nodes were collected from colectomy specimens. Read More

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November 2018

Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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November 2018
3 Reads

Initial Diagnostic Workup of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement Summary of the CAP and ASH Guideline.

J Oncol Pract 2018 Dec 6:JOP1800613. Epub 2018 Dec 6.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; American Society of Clinical Oncology, Alexandria, VA; and Moffitt Cancer Center, Tampa, FL.

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December 2018

Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis.

Cell Cycle 2018 Dec 6. Epub 2018 Dec 6.

b Department of Thoracic Surgery , Shengjing Hospital of China Medical University , Shenyang 110004 , Liaoning , China.

Breast cancer threatened the health of millions of people around the world. Here we explored the influence of TCDD on the expression of circRNA_BARD1 (circ_0001098) in breast cancer and studied the potential molecular mechanism of circRNA_BARD1. The data from GSE76608 was applied to analyze differentially expressed circRNAs and mRNAs. Read More

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December 2018
1 Read

Prognosis of patients with prostate cancer and middle range prostate - specific antigen levels of 20 - 100 ng / mL.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Introduction: Prostate - specific antigen (PSA) is a useful biomarker for detection of prostate cancer (PCa) and for risk classification in addition to TNM classification and Gleason score (GS). We reported the role of PSA in patients with low (< 20 ng / mL) and extremely high (≥ 100 ng / mL) PSA levels. However, it is unclear whether a correlation exists between middle range PSA levels (20 - 100 ng / mL) at diagnosis and prognosis. Read More

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October 2018

The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro-oncology center.

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

Departamento de Anatomia Patológica da Universidade Estadual de Campinas - UNICAMP, Campinas, SP, Brasil.

Introduction: In view of the detailed histologic evaluation of prostate cancer (PC), it is usually advisable to provide a "second opinion" to confirm diagnosis. This study aimed to compare the Gleason score (GS) of initial diagnosis versus that of histopathologic review of patients with PC. The secondary objective was to compare initial GS versus histopathologic review versus post - surgical histopathology. Read More

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October 2018

Dramatic polarization in genitourinary expert opinions regarding the clinical utility of positron emission tomography (PET) imaging in prostate cancer.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Objectives: To ascertain the opinions of North American genitourinary (GU) experts regarding inclusion of technologies such as prostate - specific membrane antigen (PSMA) and C - 11 choline positron emission tomography (PET) into routine practice.

Materials And Methods: A survey was distributed to North American GU experts. Questions pertained to the role of PSMA and C - 11 PET in PCa management. Read More

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October 2018

Does the experience of the bedside assistant effect the results of robotic surgeons in the learning curve of robot assisted radical prostatectomy?

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

American Hospital, Istanbul, Turkey.

Introduction: The success of the robot assisted radical prostatectomy (RARP) procedures depend on a successful team, however the literature focuses on the performance of a console surgeon. The aim of this study was to evaluate surgical outcomes of the surgeons during the learning curve in relation to the bedside assistant's experience level during RARP.

Materials And Methods: We retrospectively reviewed two non - laparoscopic, beginner robotic surgeon's cases, and we divided the patients into two groups. Read More

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October 2018
1 Read

Small cell bladder cancer: should we consider prophylactic cranial irradiation?

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Urology, University of Pittsburgh, Pennsylvania, U.S.A.

Purpose: To describe the clinical characteristics, treatment patterns, and outcomes in patients with small cell bladder cancer at our institution, including those who received prophylactic cranial irradiation (PCI) for the prevention of intracranial recurrence.

Materials And Methods: Patients with small cell bladder cancer treated at a single institution between January 1990 and August 2015 were identified and analyzed retrospectively for demographics, tumor stage, treatment, and overall survival.

Results: Of 44 patients diagnosed with small cell bladder cancer, 11 (25%) had metastatic disease at the time of presentation. Read More

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October 2018
1 Read

Breast cancer in males, case presentation and literature review

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):424-428. Epub 2018 Nov 30.

Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico ISSEMyM Ecatepec, Servicio de Cirugía General. Ecatepec, Estado de México, México

Background: Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In all cases a genetic study must be performed, in order to find mutations in known genes, and after the resolution of the disease, based on the results, a contralateral prophylactic mastectomy should be considered. Read More

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November 2018
1 Read

Chinese Expert Consensus Workshop Report: Guideline for permanent iodine-125 seed implantation of primary and metastatic lung tumors.

Thorac Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, China.

Surgery remains the first choice of cure for early stage lung cancer. However, many patients are diagnosed at advanced stage, and thus miss the opportunity to undergo surgery. As such patients derive limited benefits from chemotherapy or radiotherapy, alternatives focusing on local control have emerged, including iodine-125 seed implantation. Read More

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December 2018

The role of post-mastectomy radiotherapy in elderly patients with 1-3 positive lymph nodes breast cancer: An International Retrospective Double-Center Study.

Breast J 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Institut Curie, Paris, France.

This study evaluated the role of post-mastectomy radiotherapy (PMRT) in 111 patients with 1-3 positive nodes, aged 65 years or above between 2007 and 2013. In total, 64 received PMRT. The PMRT group had more aggressive tumor. Read More

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December 2018

A randomized, double-blind, placebo-controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Institute of Translational Medicine, Nanchang University, Nanchang, People's Republic of China.

Background: The objective of this study was to evaluate the effect of a probiotic combination on the severity of oral mucositis (OM), which is a common, unpreventable complication induced by radiochemotherapy in patients with nasopharyngeal carcinoma who undergo concurrent radiochemotherapy (CCRT).

Methods: Eligible patients (n = 99) with locally advanced nasopharyngeal carcinoma who were undergoing CCRT were randomly assigned (2:1) to receive a probiotic combination or placebo during radiochemotherapy, and the incidence of severe OM (grade 3 or higher) was the primary endpoint.

Results: Patients taking the probiotic combination showed a significant reduction in the severity of OM. Read More

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December 2018

Second infield re-irradiation with a resulting cumulative equivalent dose (EQD2 ) of >180 Gy for patients with recurrent head and neck cancer.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.

Background: For locally recurrent head and neck cancer, re-irradiation with modern techniques like stereotactic body radiotherapy is a promising, possibly curative alternative to palliative systemic therapy.

Methods: We report on 1 patient with nasopharyngeal carcinoma (NPC) and 1 patient with cutaneous squamous cell carcinoma (SCC). Both patients received full dose primary treatment (>66 Gy, EQD2), full dose re-irradiation (>50 Gy, EQD2), and a second course of re-irradiation via robotic radiosurgery (CyberKnife) for a second local recurrence. Read More

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December 2018
1 Read

A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a )/CD207 histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive immune systems. Patients with LCH, particularly those with multisystem (MS) involvement, can develop severe hyperinflammation mimicking that observed in HLH. Read More

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December 2018

Citrus fruit intake and gastric cancer: the Stomach cancer Pooling (StoP) project consortium.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20133 Milan, Italy.

Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. This study aimed at evaluating and quantifying the association between citrus fruit consumption and gastric cancer risk. We conducted a one-stage pooled analysis including 6340 cases and 14,490 controls from 15 case-control studies from the Stomach cancer Pooling (StoP) Project consortium. Read More

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December 2018
1 Read
5.085 Impact Factor

The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC.

Method: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Read More

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December 2018

Antibiotic allergy labels in hospitalised and critically ill adults: a review of current impacts of inaccurate labelling.

Br J Clin Pharmacol 2018 Dec 6. Epub 2018 Dec 6.

Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.

Antibiotic Allergy Labels (AAL) are reported by approximately 20% of hospitalised patients, yet over 85% will be negative on formal allergy testing. Hospitalised patients with an AAL have inferior patient outcomes, increased colonization with multidrug resistant organisms and frequently receive inappropriate antimicrobials. Hospitalised populations have been well studied, yet to date the impact of AALs on patients with critical illness remain less well defined. Read More

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December 2018
2 Reads

Self-management intervention for head and neck cancer couples: Results of a randomized pilot trial.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas.

Background: Patients with head and neck cancer (HNC) experience significant physical and psychological morbidity during radiotherapy (RT) that contributes to treatment interruptions and a poor quality of life. Although spouses/partners can help by encouraging patient self-management (eg, self-care) during RT, they often experience high psychological distress rates, lack basic health care knowledge and skills, and report increased marital conflict regarding patient self-management. The current pilot study examined the feasibility and acceptability of a 6-session telephone-based intervention called Spouses coping with the Head And neck Radiation Experience (SHARE), which teaches self-management, communication, and coping skills to patients with HNC and their spouses. Read More

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December 2018

A novel method for the determination of field output factors and output correction factors for small static fields for six diodes and a microdiamond detector in megavoltage photon beams.

Med Phys 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.

Purpose: The goal of this work is to provide a large and consistent set of data for detector specific output correction factors, , for small static fields for seven solid state detectors and to determine field output factors, , using EBT3 radiochromic films and W1 plastic scintillator as reference detectors on two different linear accelerators and four megavoltage photon beams. Consistent measurement conditions and recommendations given in the International Code of PracticeTRS-483 for small field dosimetry were followed throughout the study.

Methods: were determined on two linacs, Elekta Versa HD and Varian TrueBeam, for 6 and 10 MV beams with and without flattening filter and for nine fields ranging from 0. Read More

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December 2018
2 Reads

Oligometastatic prostate cancer: Reality or figment of imagination.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, Illinois.

The term "oligometastatic prostate cancer" refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Read More

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December 2018
1 Read

Mediation of Associations Between Adiposity and Colorectal Cancer Risk by Inflammatory and Metabolic Biomarkers.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Inflammation and hyperinsulinemia may drive associations between adiposity and colorectal cancer (CRC) risk, but few studies have examined this hypothesis using mediation analysis. We used inverse odds ratio weighting and logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for estimated total effects (OR ) of body mass index, waist circumference, and adult weight gain on CRC risk, and estimated effects operating through seven inflammatory and metabolic biomarkers (natural indirect effect; OR ) or through paths independent of these biomarkers (natural direct effect; OR ) among 209 CRC cases and 382 matched controls nested within the Health Professionals Follow-up Study, a prospective cohort of male health professionals. A one-interquartile range (IQR) increase in body mass index (3. Read More

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December 2018
1 Read

Universal screening for Lynch Syndrome in a large consecutive cohort of Chinese colorectal cancer patients: high prevalence and unique molecular features.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

The prevalence of Lynch syndrome (LS) varies significantly in different populations, suggesting that ethnic features might play an important role. We enrolled 3330 consecutive Chinese patients who had surgical resection for newly diagnosed colorectal cancer. Universal screening for LS was implemented, including immunohistochemistry for mismatch repair (MMR) proteins, BRAF mutation test and germline sequencing. Read More

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December 2018
1 Read

Analysis of a lectin microarray identifies altered sialylation of mouse serum glycoproteins induced by whole-body radiation exposure.

J Radiat Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, Japan.

Microarrays containing 45 different lectins were analyzed to identify global changes in the glycosylation of serum glycoproteins from mice exposed to whole-body γ-radiation. The results showed that radiation exposure increased and decreased the relative amounts of α-2,3- and α-2,6-sialic acids, respectively. The expression of α-2,3- and α-2,6-sialyltransferase genes in the liver was analyzed to determine whether changes in their expression were responsible for the sialic acid changes. Read More

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December 2018
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Differences in peripheral and tissue immune cell populations following hematopoietic stem cell transplantation in Crohn's disease patients.

J Crohns Colitis 2018 Dec 6. Epub 2018 Dec 6.

Department of Gastroenterology, IDIBAPS, Hospital Clínic, Barcelona, Spain.

Background And Aims: Recent studies show the efficacy of autologous hematopoietic stem cell transplantation (HSCT) in severely refractory Crohn's disease (CD) patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available.

Methods: We followed a group of CD patients (n=18) receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. Read More

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December 2018
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Normal Weight Adiposity and Postmenopausal Breast Cancer Risk.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Division of Medical Oncology and Hematology, Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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December 2018

Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Weill Cornell Medical College, New York, New York.

Importance: Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women. Whether excess adiposity is associated with increased risk in women with a normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is unknown.

Objective: To investigate the association between body fat and breast cancer risk in women with normal BMI. Read More

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December 2018
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Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study.

J Natl Cancer Inst 2018 Dec 6. Epub 2018 Dec 6.

Nanchang Center for Disease Control and Prevention, Nanchang, China.

Background: There is international consensus that benzene exposure is causally related to acute myeloid leukemia (AML), and more recent evidence of association with myelodysplastic syndromes (MDS). However, there are uncertainties about the exposure response, particularly risks by time since exposure and age at exposure.

Methods: In a case-cohort study in 110 631 Chinese workers followed up during 1972-1999 we evaluated combined MDS/AML (n = 44) and chronic myeloid leukemia (n = 18). Read More

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December 2018
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Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor 2-Positive Breast Cancer-Reply.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

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December 2018
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