3,343,087 results match your criteria Oncology Williston Park N.Y.[Journal]


Urine metabolic profiles in paediatric asthma.

Respirology 2019 Feb 14. Epub 2019 Feb 14.

Department of Paediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Background And Objective: Asthma is a global problem and complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma and provided insights into asthmatic pathophysiology.

Methods: Children (aged 6-11 years) meeting the criteria for healthy control (n = 29), uncontrolled asthma (n = 37) or controlled asthma (n = 43) were enrolled. Read More

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http://dx.doi.org/10.1111/resp.13479DOI Listing
February 2019

Digital PCR in bone marrow trephine biopsies is highly sensitive for MYD88 detection in lymphomas with plasmacytic/plasmacytoid differentiation.

Br J Haematol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Pathology, Neuropathology and Molecular Pathology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1111/bjh.15792DOI Listing
February 2019
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Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer.

Oncology 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Pharmacy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Purpose: Hand-foot skin reaction (HFSR) can deteriorate quality of life in patients receiving regorafenib. Cutaneous toxicity is a main adverse effect of multikinase inhibitors and has also been associated with clinical outcome. This study assessed the association between the antitumor efficacy of regorafenib and HFSR in patients with metastatic colorectal cancer (mCRC). Read More

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http://dx.doi.org/10.1159/000495989DOI Listing
February 2019

Tumor Cavity Recurrence after Stereotactic Radiosurgery of Surgically Resected Brain Metastases: Implication of Deviations from Contouring Guidelines.

Stereotact Funct Neurosurg 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia,

Background: Significant heterogeneity exists in target volumes for postoperative stereotactic radiosurgery (SRS) for brain metastases. A set of contouring guidelines was recently published, and we investigated the impact of deviations.

Methods: Patients (n = 41) undergoing single-fraction Gamma Knife SRS following surgical resection of brain metastases from 2011 to 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1159/000496156DOI Listing
February 2019

Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer.

Digestion 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background/aims: Runt-related transcription factor (RUNX) 3 is a tumor suppressor whose expression is reduced in non-neoplastic rectal mucosa of patients with ulcerative colitis (UC) with coexisting colitis-associated cancer (CAC). We aimed to evaluate RUNX3 utility as a predictive marker for CAC using immunohistochemistry (IHC) for non-neoplastic UC mucosa.

Methods: We retrospectively compared the RUNX3 expression detected by IHC between non-neoplastic rectal biopsy specimens from 20 cases with invasive cancer (CAC group) and 20 cases selected from 138 patients without CAC (non-CAC group) that were treated during the same period (2006-2017) and were matched for sex, duration, extension, and age. Read More

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http://dx.doi.org/10.1159/000497272DOI Listing
February 2019

Comprehensive Investigation of miRNome Identifies Novel Candidate miRNA-mRNA Interactions Implicated in T-Cell Acute Lymphoblastic Leukemia.

Neoplasia 2019 Feb 11;21(3):294-310. Epub 2019 Feb 11.

Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland. Electronic address:

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy originating from T-cell precursors. The genetic landscape of T-ALL has been largely characterized by next-generation sequencing. Yet, the transcriptome of miRNAs (miRNome) of T-ALL has been less extensively studied. Read More

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http://dx.doi.org/10.1016/j.neo.2019.01.004DOI Listing
February 2019

The hemostasis system in children with hereditary spherocytosis.

Thromb Res 2019 Feb 5;176:11-17. Epub 2019 Feb 5.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia.

Introduction: Patients with hereditary spherocytosis (HS) are characterized by having an increased risk for thrombosis. An early manifestation of thrombotic complications can occur even in childhood, especially after surgery. Hypercoagulability can be associated with hemolytic crises. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.004DOI Listing
February 2019

Osimertinib plus durvalumab versus osimertinib monotherapy in EGFR T790M-positive NSCLC following previous EGFR-TKI therapy: CAURAL brief report.

J Thorac Oncol 2019 Feb 11. Epub 2019 Feb 11.

Thoracic Oncology Program, Vanderbilt University Medical Center, Nashville, TN, USA.

Introduction: Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Durvalumab is an anti-PD-L1 monoclonal antibody. The Phase III open-label CAURAL trial (NCT02454933) investigated osimertinib plus durvalumab versus osimertinib monotherapy in patients with EGFR-TKI sensitizing and T790M mutation-positive advanced non-small cell lung cancer (NSCLC) and disease progression following EGFR-TKI therapy. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.001DOI Listing
February 2019

2017-2018 Scientific Advances in Thoracic Oncology: Small Cell Lung Cancer.

J Thorac Oncol 2019 Feb 11. Epub 2019 Feb 11.

Centrum für Integrierte Onkologie Köln Bonn am Universitätsklinikum Köln, Köln, Germany.

Small cell lung cancer remains an aggressive, deadly cancer with only modest effect on survival from standard chemotherapy. However, with the advent of immunotherapy and comprehensive genomic and transcriptomic profiling, multiple new targets are showing promise in the clinical arena, and just recently PD-L1 inhibition has been shown to improve the efficacy of standard chemotherapy in extended disease SCLC. Our increasing understanding of the interactions between different pathways will enable more tailored immuno- as well as targeted therapies based on specific biomarkers and rational combinations. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.022DOI Listing
February 2019

Survivor and Clinician Assessment of Survivorship Care Plans for Hematopoietic Stem Cell Transplant Patients: An Engineering, Primary Care, and Oncology Collaborative for Survivorship Health.

Biol Blood Marrow Transplant 2019 Feb 11. Epub 2019 Feb 11.

University of Wisconsin, Madison; University of Wisconsin Carbone Cancer Center. Electronic address:

Background: The long-term care of hematopoietic stem cell transplant (HSCT) survivors poses special challenges due to a myriad of possible chronic and/or late complications. Survivorship care plans (SCPs) have been proposed as a tool to communicate information regarding the late effects of treatment and recommended follow-up care to clinicians and survivors. Our primary objective was to determine SCP content and format as well as to assess preferred timing of SCP provision following HSCT. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.003DOI Listing
February 2019

USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.

Cancer Lett 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory of Molecular Oncology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PR China. Electronic address:

Snail is an important transcription factor of epithelial-mesenchymal transition (EMT) and related to poor prognosis and distant metastasis of tumor patients. Snail is a liable protein and degraded by ubiquitin-proteasome system. There are various E3 ligases mediating its degradation, but the deubiquitinating enzyme reversed Snail degradation is not fully understood. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.007DOI Listing
February 2019

Neutrophil to Lymphocyte Ratio and Mortality in Spinal Epidural Abscess.

Spine J 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School. Electronic address:

Background Context: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have been previously identified as markers for overall survival in oncology but remain heretofore unexplored in spinal epidural abscess (SEA).

Purpose: The purpose of this study was to determine the impact of these routinely collected assessments on ninety-day mortality in SEA.

Study Design/setting: Retrospective, case-control study PATIENT SAMPLE: Patients 18 years or older diagnosed with SEA at two academic medical centers and three community hospitals OUTCOME MEASURES: Ninety-day post-discharge and in-hospital mortality METHODS: Complete blood count with differential obtained on the day immediately preceding or on the day of admission was used to calculate platelet to lymphocyte and neutrophil to lymphocyte ratios. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.02.005DOI Listing
February 2019

The optimal use of imaging in Radiation Therapy for lymphoma - Guidelines from the International Lymphoma Radiation Oncology Group (ILROG).

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Radiation therapy (RT) for the management of lymphomas has evolved over the past decades. Large extended or involved fields have been replaced by smaller involved site or nodal volumes. Currently, customized plans are created for each individual patient that encompass only the areas involved by disease. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.001DOI Listing
February 2019

Mind the gap: an analysis of 'gap year' prevalence, productivity, and perspectives among radiation oncology residency applicants.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Purpose: Medical students may take a year off during medical school (a "gap year") to strengthen their applications for competitive specialties such as radiation oncology. This can incur significant financial and opportunity costs. We sought to understand the prevalence, nature, and funding of gap years undertaken by radiation oncology applicants. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.006DOI Listing
February 2019

Reduced-dose Radiation Therapy to the Primary Site is Effective for High-risk Neuroblastoma: Results from a Prospective Trial.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York New York. Electronic address:

Purpose: For patients with high-risk neuroblastoma (HR-NB), a dose of 21 Gy to the primary tumor site after gross total resection (GTR) provides excellent local control. However, no clinical trial has specifically evaluated the optimal dose of radiation therapy (RT), and RT-related long-term toxicities are of increasing concern. We sought to assess local control, survival outcomes, and toxicity after a reduction in dose to the primary site from 21 Gy to 18 Gy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193019
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http://dx.doi.org/10.1016/j.ijrobp.2019.02.004DOI Listing
February 2019
1 Read

Patterns of Failure and Survival Outcomes After Total Lymphoid Irradiation and High-Dose Chemotherapy With Autologous Stem Cell Transplantation for Relapsed or Refractory Classical Hodgkin Lymphoma.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:

Purpose: The patterns of failure and long-term outcomes of patients with relapsed or refractory classical Hodgkin lymphoma (cHL) treated with total lymphoid irradiation (TLI) and high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (aSCT) is reported.

Methods And Materials: Patients with biopsy-proven primary refractory/relapsed cHL who received salvage chemotherapy and accelerated hyperfractionated TLI prior to HDCT and aSCT were included. Patterns of failure were delineated after fusing pretransplant planning computed tomography (CT) scan to the scan reporting the first failure. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.007DOI Listing
February 2019

Cardiac Function After Radiotherapy for Breast Cancer.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30, 001, 9700 RB Groningen, The Netherlands. Electronic address:

Purpose: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT).

Methods And Materials: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.003DOI Listing
February 2019

Corneal Substructure Dosimetry Predicts Corneal Toxicity in Patients with Uveal Melanoma Treated with Proton Beam Therapy.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Purpose: The present study examines the relationship between dose to corneal substructures and incidence of corneal toxicity within six months of proton beam therapy (PBT) for uveal melanoma. We aim to develop clinically meaningful dose constraints that can be used to mitigate corneal toxicity.

Methods And Materials: Ninety-two patients were treated with PBT between 2015 and 2017 and evaluated for grade 2+ (GR2+), intervention-requiring corneal toxicity in our prospectively maintained database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193019
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http://dx.doi.org/10.1016/j.ijrobp.2019.02.005DOI Listing
February 2019
1 Read

Morphine, but not methadone, inhibits microsomal prostaglandin E synthase-1 and prostaglandin-endoperoxide synthase 2 in lipopolysaccharide-stimulated horse synoviocytes.

Biochimie 2019 Feb 11. Epub 2019 Feb 11.

Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil. Electronic address:

Osteoarthritis (OA) is one of the main locomotor disorders in horses. Although nonsteroidal anti-inflammatory drugs are the first-line treatment for OA, opioids could also be used. In previous studies, opioids showed promising anti-inflammatory and analgesic effects. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.02.004DOI Listing
February 2019

PEGylated peptide to TIP1 is a novel targeting agent that binds specifically to various cancers in vivo.

J Control Release 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

Targeted molecular imaging allows specific visualization and monitoring of tumors. Cancer-specific peptides have been developed for imaging and therapy. Peptides that specifically target cancer have several advantages including, ease of synthesis, low antigenicity, and enhanced diffusion into tissues. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.008DOI Listing
February 2019

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors.

Cell Host Microbe 2019 Feb;25(2):324-335.e4

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada. Electronic address:

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3-4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Read More

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http://dx.doi.org/10.1016/j.chom.2019.01.011DOI Listing
February 2019

Titanium Lag Screw Versus Miniplate Fixation in the Treatment of Anterior Mandibular Fractures.

J Oral Maxillofac Surg 2019 Jan 15. Epub 2019 Jan 15.

Resident and Postdoctoral Researcher, Departments of Periodontics and Endodontics and Oral Biology, School of Dental Medicine, SUNY Buffalo, Buffalo, NY.

Purpose: The use of plates for open reduction and internal fixation of mandibular fractures has become a widely accepted method in the past 3 decades. However, the anterior mandible is well suited to lag screw fixation owing to the thickness of its bony cortices. Hence, the purpose of the present study was to comparatively evaluate clinical outcomes of fixation using lag screws and miniplates in anterior mandibular fractures. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.001DOI Listing
January 2019

Taxane-based chemohormonal therapy for metastatic hormone-sensitive prostate cancer: A Cochrane Review.

BJU Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Minnesota, Minneapolis, USA.

Objectives: Androgen deprivation therapy (ADT) has historically been the main management option for men with metastatic, hormone-sensitive prostate cancer. Over the last two decades, a number of agents have demonstrated a benefit in castration-resistant disease[1] and there has been interest to employ these drugs earlier in the disease course when the cancer is hormone-sensitive. Taxane-based chemotherapy has been utilized in such a manner and we aimed to assess the effects of early taxane-based chemohormonal therapy for newly diagnosed, metastatic, hormone-sensitive prostate cancer. Read More

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http://dx.doi.org/10.1111/bju.14711DOI Listing
February 2019

Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice.

Mol Nutr Food Res 2019 Feb 14:e1800636. Epub 2019 Feb 14.

J. Gu, J. M. Thomas-Ahner, K. M. Riedl, M. T. Bailey, Y. Vodovotz, S. J. Schwartz, S. K. Clinton, Comprehensive Cancer Center, The Ohio State University, Columbus, OH.

Scope: Black raspberries (BRB) are a rich source of bioactive phytochemicals, including anthocyanins and ellagitannins. These phytochemicals are poorly absorbed and we hypothesize that upon reaching the colon they may be transformed by gut microbiota into various metabolites that may impact the colonic mucosa or upon absorption have systemic bioactivity. The objective of this study was to define the impact of a BRB-containing diet on the colon microbiome in mice and quantify the phytochemical metabolites in the colon contents and the circulation. Read More

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http://dx.doi.org/10.1002/mnfr.201800636DOI Listing
February 2019
1 Read

Trends and Risk Factors in Orthopedic Lawsuits: Analysis of a National Legal Database.

Orthopedics 2019 Feb 14:1-8. Epub 2019 Feb 14.

Orthopedic surgeons frequently encounter medical malpractice claims. The purpose of this study was to assess trends and risk factors in lawsuits brought against orthopedic surgeons using a national legal database. A legal research service was used to search publicly available settlement and verdict reports between 1988 and 2013 by terms "orthopaedic or orthopedic" and "malpractice. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01477447-2019
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http://dx.doi.org/10.3928/01477447-20190211-01DOI Listing
February 2019
1 Read

Evaluating Risks and Benefits of Evolving Systemic Treatments of Neuroendocrine Tumors.

JAMA Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2018.6694DOI Listing
February 2019

Therapeutic Options for Neuroendocrine Tumors: A Systematic Review and Network Meta-analysis.

JAMA Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Nuclear Medicine, University Hospital, University of Geneva, Geneva, Switzerland.

Importance: Multiple therapies are currently available for patients with neuroendocrine tumors (NETs), yet many therapies have not been compared head-to-head within randomized clinical trials (RCTs).

Objective: To assess the relative safety and efficacy of therapies for NETs.

Data Sources: PubMed, Embase, the Cochrane Central Register of Controlled Trials, trial registries, meeting abstracts, and reference lists from January 1, 1947, to March 2, 2018, were searched. Read More

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http://dx.doi.org/10.1001/jamaoncol.2018.6720DOI Listing
February 2019

Trends in Smoking and e-Cigarette Use Among US Patients With Cancer, 2014-2017.

JAMA Oncol 2019 Feb 14. Epub 2019 Feb 14.

Dana-Farber Cancer Institute, McGraw/Patterson Center for Population Sciences, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2018.6858DOI Listing
February 2019

JAMA Oncology.

Authors:

JAMA Oncol 2019 Feb;5(2):138

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http://dx.doi.org/10.1001/jamaoncol.2018.4738DOI Listing
February 2019

Quality of Life in Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase 3 Randomized Clinical Trial.

JAMA Oncol 2019 Feb 14. Epub 2019 Feb 14.

Henry Ford Hospital, Detroit, Michigan.

Importance: Hypofractionated radiotherapy (HRT) would be more convenient for men with low-risk prostate cancer and cost less than conventional radiotherapy (CRT) as long as HRT is noninferior to CRT in terms of survival and quality of life (QOL) is not found to be worse.

Objective: To assess differences in QOL between men with low-risk prostate cancer who are treated with HRT vs CRT.

Design, Setting, And Participants: In this phase 3 randomized clinical trial, men with low-risk prostate cancer were enrolled from sites within the National Cancer Institute's National Clinical Trials Network in the United States, Canada, and Switzerland. Read More

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http://dx.doi.org/10.1001/jamaoncol.2018.6752DOI Listing
February 2019

Highly efficient and sensitive patient-specific quality assurance for spot-scanned proton therapy.

PLoS One 2019 14;14(2):e0212412. Epub 2019 Feb 14.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, United States of America.

The purpose of this work was to develop an end-to-end patient-specific quality assurance (QA) technique for spot-scanned proton therapy that is more sensitive and efficient than traditional approaches. The patient-specific methodology relies on independently verifying the accuracy of the delivered proton fluence and the dose calculation in the heterogeneous patient volume. A Monte Carlo dose calculation engine, which was developed in-house, recalculates a planned dose distribution on the patient CT data set to verify the dose distribution represented by the treatment planning system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212412PLOS
February 2019

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.

PLoS One 2019 14;14(2):e0211916. Epub 2019 Feb 14.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Objectives: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211916PLOS
February 2019

A comparison of the Muenster, SIOP Boston, Brock, Chang and CTCAEv4.03 ototoxicity grading scales applied to 3,799 audiograms of childhood cancer patients treated with platinum-based chemotherapy.

PLoS One 2019 14;14(2):e0210646. Epub 2019 Feb 14.

BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

Childhood cancer patients treated with platinums often develop hearing loss and the degree is classified according to different scales globally. Our objective was to compare concordance between five well-known ototoxicity scales used for childhood cancer patients. Audiometric test results (n = 654) were evaluated longitudinally and graded according Brock, Chang, International Society of Pediatric Oncology (SIOP) Boston, Muenster scales and the U. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210646PLOS
February 2019

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

A Maia, INTERNAL MEDICINE, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL, Porto Alegre, 90035-003, Brazil.

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumours. Several reports have demonstrated that the RET mutation profile may vary according to geographical area. In this study we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. Read More

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http://dx.doi.org/10.1530/EC-18-0506DOI Listing
February 2019

Dynamic Load Balancing Strategy for Parallel Tumor Growth Simulations.

J Integr Bioinform 2019 Feb 14. Epub 2019 Feb 14.

University of Granada, Granada, Spain.

In this paper, we propose a parallel cellular automaton tumor growth model that includes load balancing of cells distribution among computational threads with the introduction of adjusting parameters. The obtained results show a fair reduction in execution time and improved speedup compared with the sequential tumor growth simulation program currently referenced in tumoral biology. The dynamic data structures of the model can be extended to address additional tumor growth characteristics such as angiogenesis and nutrient intake dependencies. Read More

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http://dx.doi.org/10.1515/jib-2018-0066DOI Listing
February 2019

Are there differences between de novo and secondary upper tract urothelial carcinoma tumours?

Can Urol Assoc J 2019 Jan 21. Epub 2019 Jan 21.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada.

Introduction: Upper tract urothelial carcinoma (UTUC) accounts for <5% of all urothelial cancers. We aimed to ascertain the clinical differences between UTUC tumours presenting de novo (DnUTUC) and those presenting secondary (SUTUC) following a bladder cancer diagnosis.

Methods: Our institutional database was queried for all UTUC patients who were surgically treated with radical nephroureterectomy or ureterectomy between 2003 and 2017. Read More

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http://dx.doi.org/10.5489/cuaj.5595DOI Listing
January 2019

Looking Through the Lens of a Family Planner to Prioritize Reproductive Health Among Women With Cancer.

J Oncol Pract 2019 Feb 17;15(2):e141-e152. Epub 2018 Dec 17.

1 John H. Stroger, Jr Hospital of Cook County, Chicago, IL.

Purpose:: Prioritization of cancer treatment initiation in women of reproductive age may underscore potential implications on reproductive health. This study describes a family planning quotient (FPQ) and reproductive life index (RepLI) tool designed to help providers to discuss effectively reproductive health with women with cancer.

Methods:: We tailored the FPQ/RepLI tool for patients with cancer after development in the family planning setting and piloted it with 36 oncology patients referred to our family planning clinic. Read More

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http://dx.doi.org/10.1200/JOP.18.00429DOI Listing
February 2019

Residual Disease after Neoadjuvant Therapy - Developing Drugs for High-Risk Early Breast Cancer.

N Engl J Med 2019 Feb;380(7):612-615

From the Office of Hematology and Oncology Products, Center for Drug Evaluation and Research (T.M.P., J.A.B.), and the Oncology Center of Excellence (R.P.), Food and Drug Administration, Silver Spring, and the Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore (T.M.P., J.A.B.) - both in Maryland.

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http://dx.doi.org/10.1056/NEJMp1900079DOI Listing
February 2019

More on Blastic Plasmacytoid Dendritic-Cell Neoplasms.

Authors:

N Engl J Med 2019 Feb;380(7):695-697

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http://dx.doi.org/10.1056/NEJMc1814963DOI Listing
February 2019

Price competition and reimbursement of biosimilar granulocyte-colony stimulating factor in Hungary.

Expert Rev Pharmacoecon Outcomes Res 2019 Feb 14. Epub 2019 Feb 14.

a University of Pécs, Faculty of Health Sciences , Institute for Health Insurance , Pécs , 7621 Pécs, Mária utca 5-7, Hungary .

Objectives: After patent expiration of original biological drugs, they can be marketed as biosimilars. In this study, we analyzed the bid approach of the Hungarian National Health Insurance Fund Administration (NHIFA) based on the results of two consecutive bids on colony stimulating factor (CSF).

Methods: The Hungarian NHIFA database was used to analyze the changes in the number of patients treated with CSF and reimbursement paid by NHIFA, 12 months preceding and following the bids. Read More

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http://dx.doi.org/10.1080/14737167.2019.1582334DOI Listing
February 2019

Biological therapies in lung cancer treatment: using our immune system as an ally to defeat the malignancy.

Expert Opin Biol Ther 2019 Feb 14. Epub 2019 Feb 14.

a Institute for Health Science Research Germans Trias i Pujol (IGTP) , Badalona , Spain.

Introduction: Biological therapies, with immunotherapy leading the field, have arisen as one of the quickest expanding areas of research for cancer treatment in the last few years. The clear benefits for patients are undeniable, satisfying the long-awaited necessity of a target-specific therapy. However, its full potential remains still unexploited due to a lack of response in a majority of patients and pending reliable biomarkers. Read More

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http://dx.doi.org/10.1080/14712598.2019.1582635DOI Listing
February 2019

Two case reports of synchronous unilateral pleomorphic adenoma and cystadenolymphoma of the parotid gland with literature review.

J Ultrason 2018 ;18(75):369-373

Department of Otorhinolaryngology, Head and Neck Surgery , Klinikum Augsburg, Augsburg , Germany.

Synchronous unilateral tumors in the parotid glands account for less than 5-10% of all salivary gland neoplasms. Mostly these are cystadenolymphomas, but tumors of different histological types can be found as well. In these cases it is often pleomorphic adenoma in combination with cystadenolymphoma. Read More

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http://dx.doi.org/10.15557/JoU.2018.0055DOI Listing
January 2018

S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up.

J Dtsch Dermatol Ges 2019 Feb;17(2):214-230

Department of Dermatology, Mainz University Medical Center, Mainz, Germany.

Basal cell carcinoma (BCC) is the most common malignant tumor among fair-skinned individuals, and its incidence had been steadily rising in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 2 addresses issues such as proper risk stratification, the various therapeutic approaches, and prevention as well as follow-up of patients with basal cell carcinoma. Read More

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http://dx.doi.org/10.1111/ddg.13755DOI Listing
February 2019

Reconstruction of defects of the proximal nasal sidewall using the procerus perforator flap.

J Dtsch Dermatol Ges 2019 Feb;17(2):210-213

Department of Dermatology, Venereology and Allergology, Mannheim University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/ddg.13752DOI Listing
February 2019

Spironolactone-induced XPB degradation depends on CDK7 kinase and SCF E3 ligase.

Genes Cells 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Human Molecular Genetics, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.

The multi-subunit complex transcription factor IIH (TFIIH) has dual functions in transcriptional initiation and nucleotide excision repair (NER). TFIIH is comprised of two subcomplexes, the core subcomplex (7 subunits) including XPB and XPD helicases and the cyclin-dependent kinase (CDK)-activating kinase (CAK) subcomplex (3 subunits) containing CDK7 kinase. Recently, it has been reported that spironolactone, an anti-aldosterone drug, inhibits cellular NER by inducing proteasomal degradation of XPB and potentiates the cytotoxicity of platinum-based drugs in cancer cells, suggesting possible drug repositioning. Read More

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http://dx.doi.org/10.1111/gtc.12674DOI Listing
February 2019

Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement.

Head Neck 2019 Feb 14. Epub 2019 Feb 14.

Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Background: Parotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien.

Methods: In total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed.

Results: Lymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Read More

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http://dx.doi.org/10.1002/hed.25670DOI Listing
February 2019

Gut microbiota signatures and lipids metabolism profiles by exposure to polyene phosphatidylcholine.

Biofactors 2019 Feb 14. Epub 2019 Feb 14.

Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China.

The aim of the study was to address the causality links and identify specific features of the gut microbiota signatures contributing to host lipids metabolism in the presence or absence of polyene phosphatidylcholine (PPC) administration, and evaluate potential risk of PPC consumption. About 20 C57BL/6J mice were randomly allocated into two groups, normal diet group (CK) and PPC administration group (205.2 mg/kg). Read More

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http://dx.doi.org/10.1002/biof.1495DOI Listing
February 2019

Algorithms for ascertaining keratinocyte carcinomas using health insurance claims and prescription records.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Skin Science, University of British Columbia.

Skin cancer is the most common human malignancy with an ongoing continual increase in global incidence. Despite their high prevalence, keratinocyte carcinomas (KCs), namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are often excluded from population-based cancer registries. As there are over 3000 defined skin disease varieties that can be diagnosed, robust ascertainment methods are needed to capture KC cases for epidemiologic purposes. Read More

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http://dx.doi.org/10.1111/jdv.15490DOI Listing
February 2019
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