3,372,293 results match your criteria Oncology Times UK Edition [Journal]


Oxytocin in the tumor microenvironment is associated with lower inflammation and longer survival in advanced epithelial ovarian cancer patients.

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.007DOI Listing
April 2019
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An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma.

Eur J Cancer 2019 Apr 17;114:1-7. Epub 2019 Apr 17.

Department of Surgical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.010DOI Listing

Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study.

Ecotoxicol Environ Saf 2019 Apr 17;178:168-177. Epub 2019 Apr 17.

Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

Objectives: Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.

Methods: In this case-control study, 42 patients with CRC and 30 healthy subjects were selected. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.030DOI Listing

Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis.

J Surg Res 2019 Apr 17;241:31-39. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193015
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http://dx.doi.org/10.1016/j.jss.2019.03.036DOI Listing
April 2019
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Cost-Effectiveness of Sentinel Lymph Node Biopsy for Head and Neck Cutaneous Squamous Cell Carcinoma.

J Surg Res 2019 Apr 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.040DOI Listing

Atypical teratoid/rhabdoid sellar tumor in an adult with a familial history of a germline SMARCB1 mutation: case report and review of the literature.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: Adult sellar ATRT is a rare diagnosis that has recently been shown to be a clinicopathologically and genetically distinct variant of ATRT occurring almost exclusively in middle-aged females. While up to one third of pediatric ATRT is caused by a familial syndrome, no previous cases of a familial adult sellar ATRT have been reported. We present the first case report of a familial germline mutation causing adult sellar ATRT and a literature review of 29 previously published cases of sporadic adult sellar ATRT. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.083DOI Listing

Atypical Vertebral Hemangiomas Are Frequently Associated With Radiculomedullary Arteries.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery Johns Hopkins University School of Medicine 600 N. Wolfe Street Meyer Building 7-109 Baltimore MD 21287 Office: 410-955-4424.

Background: Preoperative endovascular embolization of atypical hemangiomas of the spine can reduce intraoperative blood loss. One frequent concern raised about embolizing these tumors is a possible association with arteries feeding the spinal cord, such as the artery of Adamkiewicz.

Objective: This study aimed to elucidate a relationship between spinal levels affected by atypical spinal hemangiomas and radiculomedullary arteries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193109
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http://dx.doi.org/10.1016/j.wneu.2019.04.101DOI Listing
April 2019
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What is the optimal timing and sequence of immunotherapy when used in combination with stereotactic radiation in the treatment of brain metastases?

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Weill Medical College of Cornell University, New York, NY; Department of Radiation Oncology, Weill Medical College of Cornell University, New York, NY. Electronic address:

Checkpoint immunotherapy (CIT) is an emerging and exciting treatment modality in the treatment of cancer. Much excitement exists in the potential of CIT to revolutionize the treatment and prognosis of brain metastases. The combination of stereotactic radiosurgery (SRS) and CIT has been further studied and showed promise over treatment with either modalities alone. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.093DOI Listing

Meningioma originating from the hypoglossal canal: Case report and review of literature.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Sapporo Medical University School of Medicine.

Primary extracranial meningiomas are uncommon neoplasms. In particular, meningioma involving the hypoglossal canal is extremely rare, with only four cases reported in the literature so far. As each of these meningiomas originated in the juxta-condyle region with involving the hypoglossal canal, to the best of our knowledge, a meningioma which exists only within hypoglossal canal has yet to be reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193107
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http://dx.doi.org/10.1016/j.wneu.2019.04.084DOI Listing
April 2019
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Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma.

Ageing Res Rev 2019 Apr 17. Epub 2019 Apr 17.

Cellular Oncology group, Biodonostia Health Research Institute, San Sebastian, Spain; CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), Madrid, Spain; IKERBASQUE, Basque Foundation, Bilbao, Spain. Electronic address:

Brain aging is characterized by a progressive loss of tissue integrity and function as a consequence of impaired homeostasis and regeneration capacities. The primary cilium is a highly conserved organelle that projects from the cell surface in a single copy in virtually all mammalian cell types including neural stem/progenitors cells and neurons. Increasing evidence in the last decade points out that primary cilium could be a relevant mediator of neural stem cell activity, neurogenesis, neuronal maturation and maintenance, and brain tumorigenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15681637183030
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http://dx.doi.org/10.1016/j.arr.2019.04.004DOI Listing
April 2019
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Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency.

Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Department for Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Some patients diagnosed with common variable immunodeficiency (CVID) actually suffer from combined immunodeficiency (CID) and therefore may require a different, CID-adapted treatment. Several CD4 T-cell-based criteria have been proposed in the past to identify patients with CID within the cohort of adult CVID patients. In this monocentric study, we used retrospective immunological and clinical data of 238 CVID patients to compare four different proposals of how to define CID among CVID patients. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.001DOI Listing

Left Ventricular Function After Non-Invasive Cardiac Ablation Using Proton Beam Therapy In A Porcine Model.

Heart Rhythm 2019 Apr 17. Epub 2019 Apr 17.

Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Non-invasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricle (LV) ablative radiation treatment on global LV function and volumes are unknown.

Objective: To investigate the effects of non-invasive ablation on LV function over time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15475271193035
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http://dx.doi.org/10.1016/j.hrthm.2019.04.030DOI Listing
April 2019
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Extent and Determinants of Terminally Ill Cancer Patients' Concordance between Preferred and Received Life-Sustaining Treatment States: An Advance Care Planning Randomized Trial in Taiwan.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taiwan; Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung, Taiwan. Electronic address:

Purpose: To examine the effectiveness of an advance care planning (ACP) intervention in facilitating concordance between cancer patients' preferred and received life-sustaining treatment (LST) states and to explore modifiable factors facilitating or impeding such concordance.

Methods: Terminal cancer patients (N=460) were randomly assigned 1:1 to the experimental and control arms of a randomized clinical trial, with 430 deceased participants comprising the final sample. States of preferred LSTs (cardiopulmonary resuscitation, intensive care unit care, chest compression, intubation with mechanical ventilation, intravenous nutrition, and nasogastric tube feeding) and LSTs received in the last month were examined by hidden Markov modeling. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.04.010DOI Listing
April 2019
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Fan Therapy for the Treatment of Dyspnea in Adults: a Systematic Review.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Context: The use of a handheld or electric fan has been proposed as one component of the complex clinical interventions used in the relief of dyspnea; however, there is a lack of consensus regarding its efficacy.

Objectives: We performed a systematic review to determine the effectiveness of fan therapy for the treatment of dyspnea.

Methods: We searched the Medline, EMBASE, Web of Science, Scopus, CINAHL, PsycInfo, and Cochrane Library databases to identify all fan therapy studies published from January 1, 1946 to September 31, 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08853924193017
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http://dx.doi.org/10.1016/j.jpainsymman.2019.04.011DOI Listing
April 2019
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Severe Herpes Zoster Requiring Intravenous Antiviral Treatment in Allogeneic Hematopoietic-cell Transplantation Recipients on Standard Acyclovir Prophylaxis.

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.015DOI Listing

Metabolic mechanisms of Fuzheng-Huayu formula against liver fibrosis in rats.

J Ethnopharmacol 2019 Apr 17:111888. Epub 2019 Apr 17.

Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Ethnopharmacological Relevance: Fuzheng-Huayu formula (FZHY) is traditionally used to treat liver fibrosis in clinic. The study was conducted to investigate the metabolic mechanisms of FZHY against liver fibrosis in rats.

Materials And Methods: Rats with CCl -induced liver fibrosis were treated with FZHY and its components, including amygdalin, cordyceps polysaccharide and gypenoside, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183400
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http://dx.doi.org/10.1016/j.jep.2019.111888DOI Listing
April 2019
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Targeted methods for molecular characterization of EGFR mutational profile in lung cancer Moroccan cohort.

Gene 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, Casablanca 20250, Morocco.

The study of EGFR gene mutational profile in NSCLC patients has a special clinical significance in the selection of patients for tyrosine-kinase inhibitors therapy. From 2017, the targeted therapy started to be accessible in public sector in Morocco, thus, the implementation of techniques for the molecular characterization of EGFR mutations in the laboratories became a necessity. The aim of this study was to present targeted methods "ADx-ARMS technology and the Idylla™ system" for the identification of EGFR mutational profile, methods that can be implemented in our clinical laboratories for routine analysis instead of outsourcing analysis to other countries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193039
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http://dx.doi.org/10.1016/j.gene.2019.04.044DOI Listing
April 2019
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Targeting the Deubiquitinase STAMBPL1 Triggers Apoptosis in Prostate Cancer Cells by Promoting XIAP Degradation.

Cancer Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

The zinc metalloprotease STAM-binding protein-like 1 (STAMBPL1) has been identified as a deubiquitinase by specifically cleaving Lys-63-linked polyubiquitin chains, but its cellular function remains unclear. Here we described the potential role of STAMBPL1 in suppression of the intrinsic apoptosis. We observed substantially high amounts of STAMBPL1 proteins in androgen-independent prostate cancer PC3 and DU145 cell lines. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.04.020DOI Listing

LYRM2 directly Regulates Complex I Activity to Support Tumor Growth in Colorectal Cancer by Oxidative Phosphorylation.

Cancer Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Hangzhou, 310009, China. Electronic address:

Oxidative phosphorylation (OXPHOS) in cancer has attracted a considerable attention in the past decades, and accumulated evidence has suggested that it plays an important role in tumor proliferation, metastasis and drug resistance. However, the mechanisms involved in these effects are still ambiguous to date. In this study, we found that LYR motif containing 2 (LYRM2), a novel molecule, is up-regulated in colorectal cancer and promotes tumor growth both in vivo and in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193025
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http://dx.doi.org/10.1016/j.canlet.2019.04.021DOI Listing
April 2019
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Liver-derived Cell-free Nucleic Acids in Plasma: Biology and Applications in Liquid Biopsies.

J Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China. Electronic address:

There is much global research interest into the use of cell-free DNA (cfDNA) for liquid biopsies. cfDNA-based noninvasive prenatal testing (NIPT) for fetal chromosomal aneuploidies was the first success in using cfDNA technology to profoundly transform clinical practice, and has been rapidly adopted in dozens of countries and used by millions of pregnant women every year. Prompted by such developments, efforts to use cfDNA for other fields, especially for cancer detection and monitoring have been actively pursued in recent years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193025
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http://dx.doi.org/10.1016/j.jhep.2019.04.003DOI Listing
April 2019
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MDM2 copy number increase: A poor prognostic, molecular event in esophageal squamous cell carcinoma.

Hum Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; Institute of Liver Studies, King's College Hospital, London, UK. Electronic address:

The present study aimed to elucidate the clinicopathological significance of molecular alterations in MDM2 in esophageal squamous cell carcinoma (ESCC). A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization (DISH) for MDM2 and immunohistochemistry for p53 using tissue microarrays. Clinicopathological features were correlated with the MDM2 status. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.04.002DOI Listing

Cowpea mosaic virus nanoparticles for cancer imaging and therapy.

Adv Drug Deliv Rev 2019 Apr 17. Epub 2019 Apr 17.

Department of Oncology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. Electronic address:

Nanoparticle platforms are particularly attractive for theranostic applications due to their capacity for multifunctionality and multivalency. Some of the most promising nano-scale scaffold systems have been co-opted from nature including plant viruses such as cowpea mosaic virus (CPMV). The use of plant viruses like CPMV as viral nanoparticles is advantageous for many reasons; they are non-infectious and nontoxic to humans and safe for use in intravital imaging and drug delivery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X193004
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http://dx.doi.org/10.1016/j.addr.2019.04.005DOI Listing
April 2019
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Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2.

Eur J Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, PR China. Electronic address:

Esophageal cancer, especially esophageal squamous cell carcinoma (ESCC) threatens so many lives in China every year. Traditional treatment of ESCC has usually been disappointing. The development of novel therapy is worth investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193024
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http://dx.doi.org/10.1016/j.ejphar.2019.04.018DOI Listing
April 2019
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Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.

Eur J Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, China. Electronic address:

Nasopharyngeal Carcinoma is limited by the various severe side-effects and surgery is rarely performed. Iosliquiritigenin has a series of biological activities, such as antiviral, anti-free radical and antitumor. However, the role and underlying mechanism of isoliquiritigenin in nasopharyngeal carcinoma have not been understood yet. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.033DOI Listing

Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer.

Exp Mol Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA; Center for Clinical and Translational Science (CCTS), University of Mississippi School of Pharmacy & University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor immunoevasion. Due to a lack of reports of race-specific expression of MICA in PCa, we evaluated MICA expression in patients' tumors and in cell lines from a racially diverse origin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144800193014
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http://dx.doi.org/10.1016/j.yexmp.2019.04.010DOI Listing
April 2019
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Evaluation of a Lectin-Based Imaging System for the Chairside Detection of Oral Dysplasia and Malignancy.

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Chief of Surgery, Chief and Fellowship Director, Oral and Maxillofacial Surgery, North Memorial Medical Center, Robbinsdale, MN. Electronic address:

Purpose: Currently available oral cancer screening adjuncts do not have enhanced clinical screening methods because of high false positives and negatives, highlighting the need for a molecularly specific technique for accurate screening of suspicious oral lesions. The purpose of this study was to evaluate the in vivo screening accuracy of an oral lesion identification system that evaluates aberrant glycosylation patterns using a fluorescently labeled lectin (wheat germ agglutinin and fluorescein isothiocyanate [WGA-FITC]).

Materials And Methods: The authors designed and implemented a prospective cohort study at 3 institutions composed of patients with and without suspicious oral lesions. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.012DOI Listing

Disparities in Compliance with National Guidelines for the Treatment of Malignant Pleural Mesothelioma.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Division of Thoracic Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address:

Background: Current guidelines support cancer-directed surgery, chemotherapy or active surveillance for clinical stages 1 to 3 of epithelial Malignant Pleural Mesothelioma (MPM). Definitive chemotherapy is recommended for sarcomatoid/biphasic histologies. Our objective is to assess compliance with recommendations, measuring their impact on overall survival (OS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193055
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.052DOI Listing
April 2019
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Haploidentical allogeneic hematopoietic stem cell transplantation increases the risk of cytomegalovirus infection in adult patients with acute leukemia.

Transpl Infect Dis 2019 Apr 20:e13096. Epub 2019 Apr 20.

Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taiwan.

Background: Owing to the shortage of hematopoietic stem cells from matched sibling donors (MSD) and matched unrelated donors (MUD), the number of patients undergoing haploidentical allogeneic hematopoietic stem cell transplantation (allo-HSCT) has rapidly increased. Despite a comparable overall survival (OS) and leukemia-free survival using this approach, some evidence suggests that haploidentical allo-HSCT recipients have a higher incidence of cytomegalovirus (CMV) infection, though this has not been clearly established.

Methods: This study retrospectively compared the cumulative incidence of CMV DNAemia, 2-year OS, and leukemia-free survival rates in acute leukemia patients with with MSD (n=41), MUD (n=18), and haploidentical donor allografts (n=21). Read More

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http://dx.doi.org/10.1111/tid.13096DOI Listing

Determine safety of outpatient chemotherapy and autotransplants using refrigerated, non-frozen grafts in persons with multiple sclerosis.

Clin Transplant 2019 Apr 20:e13567. Epub 2019 Apr 20.

Centro de Hematología y Medicina Interna de Puebla, Puebla, México.

Persons with multiple sclerosis (MS) are sometimes treated with intermediate- or high-dose chemotherapy and an autotransplant (1, 2). More than 1000 autotransplants are reported with MS (2-6) but use of autotransplants may be substantially more common as many cases are not reported. Recent data from a small randomized trial of less-intensive chemotherapy reported better outcomes with this approach compared with disease-modifying therapy in persons with advanced relapsing-remitting MS (7). Read More

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http://dx.doi.org/10.1111/ctr.13567DOI Listing

Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with DSD (differences in sex development).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Elizabeth Garrett Anderson UCL Institute of Women's Health, University College London Hospitals, 250 Euston Road, London, NW12PG.

Discordance between gonadal type and gender identity has often led to an assumption of infertility in patients with differences in sex development (DSD). However, there is now greater recognition of fertility being an important issue for this group of patients. Currently, gonadal tissue that may have fertility potential is not being stored for individuals with DSD and, where gonadectomy forms part of management, is often discarded. Read More

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http://dx.doi.org/10.1111/cen.13994DOI Listing

The EntOptLayout Cytoscape plug-in for the efficient visualization of major protein complexes in protein-protein interaction and signalling networks.

Bioinformatics 2019 Apr 20. Epub 2019 Apr 20.

Network Science Institute, Northeastern University, Boston MA, USA.

Motivation: Network visualizations of complex biological datasets usually result in 'hairball' images, which do not discriminate network modules.

Results: We present the EntOptLayout Cytoscape plug-in based on a recently developed network representation theory. The plug-in provides an efficient visualization of network modules, which represent major protein complexes in protein-protein interaction and signalling networks. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz257DOI Listing

The contribution of KSHV to mortality in hospitalized HIV-infected patients being investigated for tuberculosis in South Africa.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Division of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, University of Cape Town, South Africa.

Background: Despite increasing numbers of human immunodeficiency virus (HIV)-infected South Africans receiving antiretroviral therapy (ART), tuberculosis remains the leading cause of mortality. Approximately 25% of patients treated for tuberculosis have microbiologically unconfirmed diagnoses. We assessed whether elevated Kaposi's sarcoma-associated Herpes Virus (KSHV) viral load (VL) contributes to mortality in hospitalized HIV-infected patients investigated for tuberculosis. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz180DOI Listing
April 2019
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Colorectal cancer-associated ~6 kDa hyaluronan serves as a novel biomarker for cancer progression and metastasis.

FEBS J 2019 Apr 19. Epub 2019 Apr 19.

Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Low molecular weight hyaluronan (LMW-HA) is believed to accumulate in tumors and to exert pro-tumor effects. This study aimed to identify colorectal cancer (CRC)-associated LMW-HA, precisely determine its molecular weight and elucidate its role in predicting tumor progression. The molecular weight distribution of hyaluronan extracted from CRC and paired non-cancerous tissues was evaluated. Read More

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http://dx.doi.org/10.1111/febs.14859DOI Listing

Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation.

J Appl Clin Med Phys 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Purpose: Transrectal ultrasound images are routinely acquired for low dose rate (LDR) prostate brachytherapy dosimetric preplanning (pTRUS), although diagnostic multiparametric magnetic resonance imaging (mpMRI) may serve this purpose as well. We compared the predictive abilities of TRUS vs MRI relative to intraoperative TRUS (iTRUS) to assess the role of mpMRI in brachytherapy preplanning.

Materials And Methods: Retrospective analysis was performed on 32 patients who underwent iTRUS-guided prostate LDR brachytherapy as either mono- or combination therapy. Read More

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http://dx.doi.org/10.1002/acm2.12592DOI Listing

Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non-Small Cell Lung Cancer.

CPT Pharmacometrics Syst Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Iowa State University College of Veterinary Medicine, Ames, IA, U.S.A.

Bevacizumab-pemetrexed/cisplatin (BEV-PEM/CIS) is a first line therapeutic for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization. BEV-PEM/CIS has a narrow therapeutic window. Read More

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http://dx.doi.org/10.1002/psp4.12415DOI Listing
April 2019
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A novel online prognostic tool to predict long-term survival after liver resection for intrahepatic cholangiocarcinoma: The "metro-ticket" paradigm.

J Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio.

Background: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm.

Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Read More

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http://dx.doi.org/10.1002/jso.25480DOI Listing

Prostate Specific Antigen Nadir After Radical Cystoprostatectomy in Patients With Benign Prostatic Tissue: A Benchmark To Define Biochemical Recurrence after Radical Prostatectomy.

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Purpose: Biochemical failure after radical prostatectomy has been defined based on retrospective studies in men who underwent RP for localized prostate cancer. Nevertheless, retrospective strategy and possibility of extra-prostatic extension overshadowed the accurateness of the aforementioned cut-off value. To define a more precise PSA nadir value, we estimated serum PSA after cystoprostatectomy in cases with bladder urothelial cancer and no evidence of prostate cancer. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4551DOI Listing
April 2019
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Detection rate of unknown primary tumour by using somatostatin receptor PET/CT in patients with metastatic neuroendocrine tumours: a meta-analysis.

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland.

Purpose: The high diagnostic performance of somatostatin receptor positron emission tomography with computed tomography (PET/CT) in neuroendocrine tumours (NETs) was demonstrated by several articles. However, only some studies evaluated the detection rate (DR) of this imaging method in patients with metastatic NETs and unknown primary tumours (CUP-NETs). Therefore, we aimed to perform a meta-analysis to add evidence-based data in this setting. Read More

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http://dx.doi.org/10.1007/s12020-019-01934-9DOI Listing

Local-regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial).

Breast Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Purpose: Women with HER2-positive breast cancer treated prior to effective anti-HER2 therapy have higher rates of local-regional recurrence (LRR) than those with HER2-negative disease. Effective systemic therapy, however, has been shown to decrease LRR. This study examines LRR in women with HER2-positive breast cancer treated on a single-arm prospective multicenter trial of adjuvant trastuzumab (H) and paclitaxel (T). Read More

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http://dx.doi.org/10.1007/s10549-019-05238-4DOI Listing

The relation between stressful life events and breast cancer: a systematic review and meta-analysis of cohort studies.

Breast Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Social Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Purpose: Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer.

Methods: We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. Read More

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http://dx.doi.org/10.1007/s10549-019-05231-xDOI Listing
April 2019
2 Reads

Defining the Role of Lymphadenectomy for Pancreatic Neuroendocrine Tumors: An Eight-Institution Study of 695 Patients from the US Neuroendocrine Tumor Study Group.

Ann Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Background: Preoperative factors that reliably predict lymph node (LN) metastases in pancreatic neuroendocrine tumors (PanNETs) are unclear. The number of LNs needed to accurately stage PanNETs has not been defined.

Methods: Patients who underwent curative-intent resection of non-functional PanNETs at eight institutions from 2000 to 2016 were analyzed. Read More

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http://link.springer.com/10.1245/s10434-019-07367-y
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http://dx.doi.org/10.1245/s10434-019-07367-yDOI Listing
April 2019
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Unveiling the mechanisms of immune evasion in pancreatic cancer: may it be a systemic inflammation responsible for dismal survival?

Authors:
K Holub C Conill

Clin Transl Oncol 2019 Apr 19. Epub 2019 Apr 19.

Radiation Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.

Purpose: Pancreatic cancer (PC) is one of the most aggressive malignancies with no effective treatment if diagnosed in advanced stage. Systemic inflammation is a recognized characteristic of cancer progression, and we believe that the understanding of the influence of inflammatory parameters may contribute to therapeutic improvement in PC. Here, we validated the Eosinophil/Lymphocyte Ratio (ELR) together with the Neutrophil/Lymphocyte Ratio (NLR) and their components, as prognostic factors in PC patients treated with chemoradiation. Read More

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http://link.springer.com/10.1007/s12094-019-02113-y
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http://dx.doi.org/10.1007/s12094-019-02113-yDOI Listing
April 2019
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Expression of tetraspanins NET-6 and CD151 in breast cancer as a potential tumor biomarker.

Clin Exp Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Laboratory Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.

Tetraspanins have been implicated in multiple biological functions including protein networking and cell signaling. NET-6 (TSPAN 13) has been demonstrated to be a tumor suppressor gene in breast cancer, while CD151 is more likely to act as an oncogene. However, the biological function of both proteins is still inconclusive. Read More

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http://dx.doi.org/10.1007/s10238-019-00554-xDOI Listing

The Clinical Implications of Peripancreatic Fluid Collection After Distal Pancreatectomy.

World J Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Objectives: Pancreatic fistula after distal pancreatectomy (DP) remains an unsolved problem, and postoperative CT imaging often demonstrates fluid collection (FC) around the pancreatic remnant. This study sought to clarify the clinical implications of FC.

Methods: This study enrolled 146 patients who underwent DP. Read More

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http://dx.doi.org/10.1007/s00268-019-05009-8DOI Listing
April 2019
2 Reads

Locally advanced rectal cancer: qualitative and quantitative evaluation of diffusion-weighted magnetic resonance imaging in restaging after neoadjuvant chemo-radiotherapy.

Abdom Radiol (NY) 2019 Apr 19. Epub 2019 Apr 19.

Division of Radiology 2, Department of Surgical and Biomedical Sciences, Santa Maria della Misericordia Hospital, Perugia, Italy.

Purpose: To determine the added value of qualitative and quantitative evaluation of diffusion-weighted magnetic resonance imaging (DWI) in locally advanced rectal cancer (LARC) restaging after neoadjuvant chemo-radiotherapy (CRT).

Materials And Methods: A retrospective study was performed of 21 patients with LARC treated with CRT. All patients were evaluated with 1. Read More

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http://link.springer.com/10.1007/s00261-019-02012-4
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http://dx.doi.org/10.1007/s00261-019-02012-4DOI Listing
April 2019
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Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort.

Eur J Public Health 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.

Background: In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.

Methods: Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. Read More

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http://dx.doi.org/10.1093/eurpub/ckz052DOI Listing

Long-Term Change in both Dietary Insulinemic and Inflammatory Potential Is Associated with Weight Gain in Adult Women and Men.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Background: The influence of long-term dietary patterns on weight gain and the underlying potential biological mechanisms are not fully understood.

Objective: We prospectively examined the association of changes in 2 empirical hypothesis-oriented dietary patterns (insulinemic and inflammatory) and weight gain over 24 y at 4-y intervals.

Methods: We followed 54,397 women in the Nurses' Health Study and 33,043 men in the Health Professionals Follow-Up Study (1986-2010), and computed the empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores from food frequency questionnaires administered every 4 y. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy319DOI Listing
April 2019
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Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts.

Sci Rep 2019 Apr 19;9(1):6314. Epub 2019 Apr 19.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.

As patient derived xenograft (PDX) models are increasingly used for preclinical drug development, strategies to account for the nonhuman component of PDX RNA expression data are critical to its interpretation. A bioinformatics pipeline to separate donor tumor and mouse stroma transcriptome profiles was devised and tested. To examine the molecular fidelity of PDX versus donor tumors, we compared mRNA differences between paired PDX-donor tumors from nine ovarian cancer patients. Read More

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http://dx.doi.org/10.1038/s41598-019-42680-2DOI Listing

Systematic assessment of the clinicopathological prognostic significance of tissue cytokine expression for lung adenocarcinoma based on integrative analysis of TCGA data.

Sci Rep 2019 Apr 19;9(1):6301. Epub 2019 Apr 19.

Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.

Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coordinate with tumor cells to determine tumor progression and aggressiveness. In lung adenocarcinoma (LUAD), the role of intratumoral cytokine gene expression for stratifying prognosis has not been systematically investigated. Using high-dimensional datasets of cancer specimens from clinical patients in The Cancer Genome Atlas (TCGA), we explored the transcript abundance and prognostic impact of 27 clinically evaluable cytokines in 500 LUAD tumor samples according to clinicopathological features and two common driver mutations (EGFR and KRAS). Read More

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http://dx.doi.org/10.1038/s41598-019-42345-0DOI Listing

Power of observation: Sister Mary Joseph nodule.

Postgrad Med J 2019 Apr 19. Epub 2019 Apr 19.

Department of Medicine, Laniado Hospital, Netanya, Israel.

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http://dx.doi.org/10.1136/postgradmedj-2019-136516DOI Listing
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