1,721 results match your criteria Oncology Research[Journal]


Non-steroidal anti-inflammatory drugs sensitize CD44-overexpressing cancer cells to Hsp90 inhibitor through autophagy activation.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Biochemistry, Pusan National University School of Medicine, Yangsan 626-870, Korea.

Recently, novel therapeutic strategies have been designed with the aim of killing cancer stem-like cells (CSCs), and considerable interest has been generated in the development of specific therapies that target stemness-related marker of CSCs. In this study, non-steroidal anti-inflammatory drugs (NSAIDs) significantly potentiated Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)-mediated cytotoxicity through apoptotic and autophagic cell death induction, but COX-2-inhibitory function was not required for NSAID-induced autophagy in CD44-overexpressing human chronic myeloid leukemia K562 (CD44highK562) cells. Importantly, we found that treatment with NSAID resulted in a dose-dependent increase in LC3-II level and decrease in p62 level and simultaneous reduction of multiple stemness-related markers including CD44, Oct4, c-Myc and mutant p53 (mutp53) in CD44highK562 cells, suggesting that NSAIDs could induce autophagy, which might mediate degradation of stemnessrelated marker proteins. Read More

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http://dx.doi.org/10.3727/096504019X15517850319579DOI Listing

High blood miR-802 is associated with poor prognosis in HCC patients by regulating DNA damage response 1 (REDD1)-mediated function of T cells.

Oncol Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Hepatobiliary Pancreatic Surgery, First Hospital of Jilin University, Changchun 130021, China.

MiR-802 has been reported to be dysregulated in multiple tumors and contributed to tumor progression. However, its role in HCC was still largely unknown. The aim of this study is to investigate the function and mechanism of miR-802 in HCC progression. Read More

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http://dx.doi.org/10.3727/096504018X15456687424096DOI Listing

PD-L1 induces epithelial mesenchymal transition in nasopharyngeal carcinoma cells through activation PI3K/AKT pathway.

Oncol Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, P.R. China.

Nasopharyngeal cancer (NPC) is a malignant epithelial carcinoma of the head and neck. Cancer therapy targeting programmed cell death protein 1 (PD-1) or programmed death ligand-1 (PD-L1) is of revolutionary. However, the tumorigenic mechanism of PD-L1 was not yet clear in NPC. Read More

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http://dx.doi.org/10.3727/096504018X15446984186056DOI Listing

miR-205-5p contributes to paclitaxel resistance and progression of endometrial cancer by downregulating FOXO1.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmacy, the Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, 214002.

Endometrial cancer (EC) is one of the most frequent malignancies occurring in female genital system. miR-205-5p has been reported to involve in the progression of multiple malignancies, including EC. However, the detail function and mechanism of miR-205-5p in chemoresistance of EC have not been defined. Read More

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http://dx.doi.org/10.3727/096504018X15452187888839DOI Listing
April 2019
2 Reads

PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by regulating miR206.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Department of ENT, Central Hospital of Minhang District (Minhang Hospital Fudan University), Shanghai 200031, China.

In previous investigations, we reported that peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activation by GW501516 inhibits proliferation and promotes apoptosis in the undifferentiated C666-1 nasopharyngeal carcinoma (NPC) cells by modulating caspase dependent apoptotic pathway. In the present study, the mechanism by which GW501516 induces apoptosis was explored from the perspective of microRNA (miRNA) expression. Among the assayed miRNAs that were involved in regulating the expression of anti-apoptotic protein Bcl-2, miR-206 was increased significantly and specifically by GW501516 in C666-1 cells at both the in-vitro level and at the in-vivo xenograft samples. Read More

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http://dx.doi.org/10.3727/096504019X15518706875814DOI Listing

microRNA-152 inhibits cell proliferation, migration and invasion in breast cancer.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Department Breast & Thyroid Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, P.R. China.

The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly down-regulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Read More

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http://dx.doi.org/10.3727/096504019X15519249902838DOI Listing
April 2019
1 Read

MiR-148-3p inhibits growth of glioblastoma targeting DNA methyltransferase-1 (DNMT1).

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

School of Medicine, Shandong University, Jinan 250012, Shandong, P.R. China.

To date, miR-148-3p and DNMT1-recombinant human runt-related transcription factor 3 (RUNX3) axis have been linked to cell proliferation, migration and invasion; however, their roles and relationships in human glioblastoma multiforme (GBM) are still not clear. Here, we found the expression of miR-148-3p in gliomas tissues was decreased compared with adjacent non-tumor tissues, and correlated with WHO grade, tumor size and prognosis as well as DNMT1 and RUNX3 expressions. Compared with NHA cells, the expression of miR-148-3p in U87 and U251 cells was also down-regulated, and accompanied with up-regulation of DNMT1 and hyper-methylation level of RUNX3 promoter region. Read More

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http://dx.doi.org/10.3727/096504019X15516966905337DOI Listing
April 2019
1 Read

The roles of plant-derived Triptolide on non-small cell lung cancer.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Over the past decade, natural compounds have been proved to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb T. wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. Read More

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http://dx.doi.org/10.3727/096504018X15447833065047DOI Listing
April 2019
1 Read

RAS responsive element binding protein 1 blocks the granulocytic differentiation of myeloid leukemia cells.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Central Laboratory of Yong Chuan Hospital, Chongqing Medical University, Chongqing, China.

RAS responsive element binding protein 1 (RREB1) is a transcription factor which implicated in RAS signaling and multiple tumors. However, the role of RREB1 in acute myeloid leukemia has not been studied. We found that RREB1 is overexpressed in AML patients and myeloid leukemia cell lines (NB4 and HL-60), and RREB1 expression was significantly decreased during granulocytic differentiation of myeloid leukemia cells induced by all-trans retinoic acid (ATRA). Read More

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http://dx.doi.org/10.3727/096504018X15451301487729DOI Listing
April 2019
0.916 Impact Factor

MicroRNA-204 potentiates the sensitivity of acute myeloid leukemia cells to arsenic trioxide.

Oncol Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Hematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shanxi Province, People's Republic of China.

Although arsenic trioxide (ATO) is a well-known anti-leukemic drug used for acute promyelocytic leukemia treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role in chemoresistance is poorly understood. In the present study, we showed that miR-204 was significantly increased in AML cells after ATO treatment. Read More

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http://dx.doi.org/10.3727/096504019X15528367532612DOI Listing
April 2019
1 Read

MicroRNA-510 pla ys oncogenic roles in non-small cell lung cancer by directly targeting SRC kinase signaling inhibitor 1.

Oncol Res 2019 Apr 14. Epub 2019 Apr 14.

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.

Increasing number of studies demonstrated that microRNAs (miRNAs) may play key roles in various cancer carcinogenesis and progression, including non-small cell lung cancer (NSCLC). However, the expressions, roles and mechanisms of miR-510 in NSCLC have, up to now, been largely undefined. In vivo assay showed that miR-510 was upregulated in NSCLC tissues compared with that in adjacent non-tumor lung tissues. Read More

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http://dx.doi.org/10.3727/096504018X15451308507747DOI Listing
April 2019
1 Read

The Role of Toll-like Receptors in Oncotherapy.

Oncol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Pain, Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.

Toll-like receptors (TLRs) are associated with tumor growth and immunosuppression, as well as apoptosis and immune system activation. TLRs can activate apoptosis and innate and adaptive immunity pathways, which can be pharmacologically targeted for the development of anti-cancer oncotherapies. Several studies and clinical trials indicate that TLR agonists are promising adjuvants or elements of novel therapies, particularly when used in conjunction with chemotherapy or radiotherapy. Read More

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http://dx.doi.org/10.3727/096504019X15498329881440DOI Listing
March 2019
1 Read

Different Types of ROS1 Fusion Partners Yield Comparable Efficacy to Crizotinib.

Oncol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Thoracic Surgery, Shenzhen People's Hospital, Second Affiliated Hospital, Medical College of Ji'nan University, Shenzhen, China.

rearrangements define a distinct molecular subset of non-small-cell lung cancer (NSCLC), which can be treated effectively with crizotinib, a tyrosine kinase inhibitor (TKI) targeting rearrangements. Diverse efficacy was observed in -rearranged NSCLC patients. Because of its rareness, very limited studies have investigated the correlation between different fusion partners and response to crizotinib. Read More

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http://dx.doi.org/10.3727/096504019X15509372008132DOI Listing
March 2019
1 Read

VASH2 promotes cell proliferation and resistance to doxorubicin in non-small cell lung cancer via AKT signaling.

Oncol Res 2019 Apr 2. Epub 2019 Apr 2.

Department of Oncology, No. 175 Hospital of People's Liberation Army, Zhangzhou, Fujian 363000, China.

Vasohibin2 (VASH2), a pro-angiogenic factor, has been demonstrated to play an oncogenic role in some common human cancers. However, the detailed function of VASH2 in non-small cell lung cancer (NSCLC) has not previously been studied. In this study, we found that VASH2 was significantly upregulated in NSCLC tissues and cell lines, and its increased expression was associated with NSCLC progression and poor prognosis of patients. Read More

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http://dx.doi.org/10.3727/096504019X15509383469698DOI Listing

E2-induced activation of the NLRP3 inflammasome triggers pyroptosis and inhibits autophagy in HCC cells.

Oncol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, PR China.

Emerging evidence suggests that 17β-estradiol (E2) and estrogen receptor (ER) signaling are protective against hepatocellular carcinoma (HCC). In our previous study, we showed that E2 suppressed the carcinogenesis and progression of HCC by targeting NLRP3 inflammasome activation, whereas the molecular mechanism by which the NLRP3 inflammasome initiated cancer cell death was not elucidated. The present study aimed to investigate the effect of NLRP3 inflammasome activation on cell death pathways and autophagy of HCC cells. Read More

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http://dx.doi.org/10.3727/096504018X15462920753012DOI Listing
March 2019
1 Read

Inhibition of proliferation by knockdown of transmembrane (TMEM) 168 in glioblastoma cells via suppression of Wnt/beta-catenin pathway.

Oncol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, Huzhou Central Hospital, Hongqi Road 198, Huzhou, 313000, Zhejiang, China.

Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remained extremely poor. Read More

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http://dx.doi.org/10.3727/096504018X15478559215014DOI Listing
March 2019
1 Read

Anticancer effects of Gleditsia sinensis extract in rats transplanted with hepatocellular carcinoma cells.

Oncol Res 2019 Apr 2. Epub 2019 Apr 2.

Infectious disease of Wuhan Medical Treatment Center, Wuhan 430040, China.

The thorns of have been historically used in Chinese medicine, and considered one of the fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and still requires the development of new drugs with higher efficiency. Read More

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http://dx.doi.org/10.3727/096504018X15482423944678DOI Listing
April 2019
3 Reads

Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers.

Oncol Res 2019 Mar 8. Epub 2019 Mar 8.

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute to PDAC progression. Since the main cell constituents of the stroma are fibroblasts, there is cross-talking(s) between PDAC cells and surrounding fibroblasts in the stroma, which induces a fibroblast proliferation burst. We have reported that several malignant cancer cells including PDAC cells secrete a pronounced level of S100A11, which in turn stimulates proliferation of cancer cells via the receptor for advanced glycation end products (RAGE) in an autocrine manner. Read More

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http://dx.doi.org/10.3727/096504018X15433161908259DOI Listing
March 2019
2 Reads
0.916 Impact Factor

MiR-374a inhibitor enhances etoposide-induced cytotoxicity against glioma cells through upregulation of FOXO1.

Oncol Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China. 650118.

Glioma is a commonly diagnosed brain tumor that show high mortality rate. Despite the great advancement of cancer therapy in recent years, chemotherapy is still an important approach for treatment of glioma. However, long-term chemotherapy usually causes serious side-effects or complications. Read More

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http://dx.doi.org/10.3727/096504018X15426775024905DOI Listing

PAR2 inhibition enhanced the sensitivity of colorectal cancer cells to 5-FU and reduced EMT signaling.

Oncol Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

To investigate the underlying mechanisms that transforming growth factor (TGF)-β-mediated epithelial-to-mesenchymal transition (EMT) in tumor cells contributes to 5-Fu resistance. A series of experiments involving cell-viability and caspase-activity analyses, siRNA transfection, RNA isolation and quantitative-PCR (qPCR) assay, cell migration analysis, western blotting analysis of total protein and membrane protein were performed in this study. Mouse xenograft model was used to determine the effect of the PAR2 inhibitor in vivo. Read More

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http://dx.doi.org/10.3727/096504018X15442985680348DOI Listing

MiR-101 represses T-cell acute lymphoblastic leukemia by targeting CXCR7/STAT3 axis.

Oncol Res 2019 Mar 5. Epub 2019 Mar 5.

Life Science College, Luoyang Normal University, Luoyang, Henan 471003, P.R. China.

Although miR-101 is involved in the development and progression of T-cell acute lymphoblastic leukemia (T-ALL), the underlying molecular mechanisms remain unclear. In this paper, we reported that miR-101 expression was inversely correlated with CX chemokine receptor 7 (CXCR7) level in T-ALL. Introducing miR-101 inhibited T-ALL cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis in vivo. Read More

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http://dx.doi.org/10.3727/096504018X15439207752093DOI Listing
March 2019
1 Read

miR-203 inhibits the invasion and EMT of gastric cancer cells by directly targeting Annexin A4.

Oncol Res 2019 Mar 5. Epub 2019 Mar 5.

Department of First General Surgery, Cangzhou Central Hospital, Hebei 061000, People's Republic of China.

Many studies have shown that down-regulated miR-203 level is in a variety of cancers including gastric cancer (GC). However, the precise molecule mechanisms of miR-203 in GC have not been well clarified. In current study, we investigated the biological functions and molecular mechanisms of miR-203 in GC cell lines. Read More

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http://dx.doi.org/10.3727/096504018X15444387696532DOI Listing

Synergistic efficacy of the demethylation agent decitabine in combination with the protease inhibitor bortezomib for treating multiple myeloma through the Wnt/βcatenin pathway.

Oncol Res 2019 Mar 5. Epub 2019 Mar 5.

Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.

Multiple myeloma (MM) is a hematopoietic malignancy characterized by the clonal proliferation of antibody-secreting plasma cells. Bortezomib (BZM), the first FDAapproved proteasome inhibitor, has significant anti-myeloma activity and prolongs the median survival of MM patients. However, MM remains incurable predominantly due to acquired drug resistance and disease relapse. Read More

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http://dx.doi.org/10.3727/096504018X15443011011637DOI Listing
March 2019
1 Read

Knockdown of IARS2 inhibited proliferation of acute myeloid leukemia cells by regulating p53 /p21 /PCNA /eIF4E pathway.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China.

IARS2 encodes mitochondrial isoleucine-tRNA synthetase, which mutation may cause multiple diseases. But the biological function of IARS2 on acute myeloid leukemia (AML) has not yet been identified. In present study qRT-PCR was used to determine the expression of IARS2 in K562, THP1, HL-60 leukemia cells. Read More

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http://dx.doi.org/10.3727/096504018X15426261956343DOI Listing
March 2019
1 Read

Nutlin-3-induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis through Repression of Akt1/Wnt Signaling.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

Lr:17265019.

To investigate the potential biological activities of nutlin-3 (N-3) in the regulation of growth and proliferation of non-small cell lung cancer (NSCLC)stem cells (CSCs), which may help in sensitizing to axitinib-induced apoptosis. N-3 induction of p53 expression was used to test its role in controlling the cell division pattern and apoptosis of NSCLC cells. A549 cells and H460 cells were pretreated with N-3 and then treated with either an Akt1 activator or shRNA-GSK3β, to investigate the potential role of p53 sensitization in the biological effects of axitinib. Read More

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http://dx.doi.org/10.3727/096504018X15424918479652DOI Listing
March 2019
4 Reads
0.916 Impact Factor

Knockdown of LncRNA PVT1 inhibits glioma progression by regulating miR-424 expression.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Cardiothoracic Surgery, Huai-He Hospital, College of Medicine, Henan University, Kaifeng, Henan 475001, China.

Plasmacytoma variability translocation 1 (PVT1), an oncogene, has been reported to be highly expressed in many tumors, including human glioma, gastric cancer, and non-small cell lung cancer. Functionally, it could also regulate the development of tumor cells. However, its specific roles and pathogenesis in human gliomas are still not clear. Read More

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http://dx.doi.org/10.3727/096504018X15424939990246DOI Listing
March 2019
7 Reads

MicroRNA-101 targets CXCL12-mediated Akt and Snail signaling pathways to inhibit cellular proliferation and invasion in papillary thyroid carcinoma.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathophysiology, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450008, China.

Escalating evidence suggests that microRNA-101 (miR-101) implicates in the development and progression of various cancers, including papillary thyroid carcinoma (PTC). However, the biological function and molecular mechanisms of miR-101 in PTC are still unclear. In this study, we demonstrated that miR-101 expression was significantly decreased in PTC tissues and cell lines. Read More

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http://dx.doi.org/10.3727/096504018X15426763753594DOI Listing
March 2019
1 Read

Silencing of lncRNA AFAP1-AS1 inhibits cell growth and metastasis in clear cell renal cell carcinoma.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, People's Republic of China.

LncRNA AFAP1-AS1, oriented from an antisense direction to the protein-coding gene AFAP1 in the opposite strand, was upregulated in a variety of tumors and associated with poor prognosis, including lung cancer, breast cancer, ovarian cancer, and so on. However, the biological role of AFAP1-AS1 in clear cell renal cell carcinoma (ccRCC) is still unknown. Herein, we observed that AFAP1-AS1 expression was significantly upregulated in ccRCC tissues and that patients with high-level expression of AFAP1-AS1 had a shorter overall survival. Read More

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http://dx.doi.org/10.3727/096504018X15420748671075DOI Listing
March 2019
6 Reads
0.916 Impact Factor

Secreted phosphoprotein-1(SPP1) contributes to second generation EGFR tyrosine kinase inhibitor resistance in non-small cell lung cancer.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Oncology, Shanxi Province Hospital of Traditional Chinese Medicine, Taiyuan, China.

Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), afatinib, has been approved for treating mutant lung cancer patients, but the mechanism of acquired resistance to afatinib has not been well studied. In this study, we established afatinib acquired resistant cell lines. Gene array technology was used to screen changes in gene expression between afatinib-resistant lung cancer cells and parental cells. Read More

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http://dx.doi.org/10.3727/096504018X15426271404407DOI Listing
March 2019
3 Reads

OLFM4 inhibits epithelial-mesenchymal transition and metastatic potential of cervical cancer cells.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Gynecology, Jinan Women and Children's Health Hospital, Jinan, Shandong, 250001, P.R. China.

OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Read More

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http://dx.doi.org/10.3727/096504018X15399955297355DOI Listing
February 2019
3 Reads

Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated By Notch1 Pathway In Murine Mammary Carcinoma.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.

Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Read More

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http://dx.doi.org/10.3727/096504018X15415906335771DOI Listing
February 2019
1 Read

PHF8 plays an oncogene function in hepatocellular carcinoma formation.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Traditional Chinese Medicine, Jiaozhou People's Hospital, Jiaozhou, Shandong Province, China, 266300.

Hepatocellular carcinoma (HCC) has high morbidity and mortality rates, and the number of new cases and deaths from liver cancer are increasing. However, the details of the regulation in HCC remain largely unknown. Plant Homeodomain Finger protein 8 (PHF8) is a JmjC domain-containing protein. Read More

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http://dx.doi.org/10.3727/096504018X15410353669149DOI Listing
February 2019
9 Reads

Hsa_circ_0003998 promotes chemoresistance via modulation of miR-326 in lung adenocarcinoma cells.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Central Laboratory, Yinzhou People's Hospital, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.

Circular RNAs (circRNAs) represent a new class of non-coding RNAs that is involved in the development of cancer. However, little is known about their role in chemoresistance. In the present study, we found that hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines (A549/DTX and H1299/DTX) were upregulated. Read More

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http://dx.doi.org/10.3727/096504018X15420734828058DOI Listing
February 2019

High circ_100053 predicts a poor outcome for chronic myeloid leukemia and is involved in imatinib resistance.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Hematology, Hunan Provincial People's Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, China, 410002.

Chronic myeloid leukemia (CML) is a rare clonal myeloproliferative malignancy, which is caused by a reciprocal translocation between chromosomes 9 and 22 t(9;22) (q34;q11). Altered circle RNAs (circRNAs) could contribute to leukemogenesis. In this study, we aimed to investigate the expression profiling of circRNAs in CML. Read More

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http://dx.doi.org/10.3727/096504018X15412701483326DOI Listing
February 2019
1 Read

The interaction between lncRNA SNHG1 and miR-140 in regulating growth and tumorigenesis via TLR4/NF-κB pathway in cholangiocarcinoma.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.

Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. Read More

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http://dx.doi.org/10.3727/096504018X15420741307616DOI Listing
February 2019
1 Read

NOTCH3 overexpression and post-transcriptional regulation by miR-150 were associated with EGFR-TKI resistance in lung adenocarcinoma.

Oncol Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, Xuzhou 221009, China.

Acquired resistance remains a key challenge in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) therapy in lung adenocarcinoma (LUAD). Recent studies have shown that Notch signaling is associated with drug resistance. However, its role and possible mechanisms in EGFR-TKI resistance are not yet clear. Read More

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http://dx.doi.org/10.3727/096504018X15372657298381DOI Listing
February 2019
2 Reads

ERRATUM.

Oncol Res 2019 Feb;27(2):281-282

Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.

MicroRNA-200a (miR-200a) is frequently downregulated in most cancer types and plays an important role in carcinogenesis and cancer progression. In this study, we determined that miR-200a was downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, consistent with the results of our previous study. Because a previous study suggested that downregulation of miR-200a is correlated with HCC metastasis, we aimed to elucidate the mechanism underlying the role of miR-200a in metastasis in HCC. Read More

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http://dx.doi.org/10.3727/096504019X15476499940873DOI Listing
February 2019
6 Reads

1,25(OH)2D3 attenuates IL-1β-induced epithelial to mesenchymal transition through inhibiting the expression of lncTCF7.

Oncol Res 2018 Sep 4. Epub 2018 Sep 4.

Department of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, PR China.

The activated form of vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), regulates numerous cellular processes, including inhibition of cancer progression. IL-1β has been reported to facilitate cancer development, especially by inducing an epithelial-to-mesenchymal transition (EMT) in several malignant tumors. However, the underlying mechanism of 1,25(OH)2D3 and IL-1β in colorectal cancer (CRC) still remains largely unknown. Read More

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http://dx.doi.org/10.3727/096504018X15360541345000DOI Listing
September 2018
3 Reads
0.916 Impact Factor

Exosomal miR-1228 from cancer-associated fibroblasts promotes cell migration and invasion of osteosarcoma by directly targeting SCAI.

Oncol Res 2018 Aug 8. Epub 2018 Aug 8.

Department of Orthopedic, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, 215300, P. R. China.

Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. Read More

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http://dx.doi.org/10.3727/096504018X15336368805108DOI Listing
August 2018
1 Read

Clinical characteristics and molecular patterns of RET-rearranged lung cancer in Chinese patients.

Oncol Res 2018 Aug 21. Epub 2018 Aug 21.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features and therapeutic options in RET-rearranged patients remain unclear, especially in Chinese lung cancers. We retrospectively collected 6125 Chinese lung cancer patients who have been profiled using next-generation sequencing (NGS). Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1534
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http://dx.doi.org/10.3727/096504018X15344979253618DOI Listing
August 2018
10 Reads

Astragaloside IV Inhibits the Progression of Non-Small Cell Lung Cancer Through the Akt/GSK-3β/β-Catenin Pathway.

Oncol Res 2019 Mar 21;27(4):503-508. Epub 2018 Aug 21.

School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, P.R. China.

Astragaloside IV (AS-IV) is an active ingredient in and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. Cell counting kit (CCK)-8 assay and flow cytometry were performed to investigate cell survival and cell death, and Western blotting was performed to assess protein expression. Read More

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http://dx.doi.org/10.3727/096504018X15344989701565DOI Listing
March 2019
1 Read

MicroRNA-152 Acts as a Tumor Suppressor MicroRNA by Inhibiting Krüppel-Like Factor 5 in Human Cervical Cancer.

Oncol Res 2019 Feb 21;27(3):335-340. Epub 2018 Aug 21.

Department of Gynecology, Affiliated Qilu Hospital of Shandong University, Lixia District, Jinan, Shandong, P.R. China.

Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in cervical cancer (CC) are poorly understood. Also, the association between miR-152 and Krüppel-like factor 5 (KLF5) expression in CC remains unclear. Read More

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http://dx.doi.org/10.3727/096504018X15252202178408DOI Listing
February 2019
1 Read

Anemia Is a Novel Predictive Factor for the Onset of Severe Chemotherapy-Induced Peripheral Neuropathy in Lymphoma Patients Receiving Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone Therapy.

Oncol Res 2019 Mar 19;27(4):469-474. Epub 2018 May 19.

Department of Community Health Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan.

Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Read More

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http://dx.doi.org/10.3727/096504018X15267574931782DOI Listing
March 2019
2 Reads

Efficacy Evaluation of Imatinib for the Treatment of Melanoma: Evidence From a Retrospective Study.

Oncol Res 2019 Mar 3;27(4):495-501. Epub 2018 Aug 3.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, P.R. China.

Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment is a promising approach in treating advanced melanoma patients harboring mutations or amplifications. We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring mutations or amplifications. Read More

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http://dx.doi.org/10.3727/096504018X15331163433914DOI Listing
March 2019
23 Reads
0.920 Impact Factor

miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.

Oncol Res 2019 Feb 3;27(2):253-260. Epub 2018 Aug 3.

Department of Breast Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R. China.

miR-1284 has been reported to inhibit tumor growth in some human cancers, including lung cancer, ovarian cancer, and gastric cancer. Whether it regulates breast cancer progression remains elusive. In this study, we found that miR-1284 was downregulated in breast cancer tissues and cell lines compared to normal control cells. Read More

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http://dx.doi.org/10.3727/096504018X15242763477504DOI Listing
February 2019
17 Reads

Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.

Oncol Res 2018 Jul 23. Epub 2018 Jul 23.

Department of Tumor radiotherapy intervention, Xianyang City Central Hospital, Xianyang, Shaanxi, 712000, China.

Non-small cell lung cancer (NSCLC) is the most common lung cancer with 15.9% of predicted 5-year survival rate which represents extremely poor prognosis. In this study, we aimed to investigate the effects of Biochanin A (BIO-A) on NSCLC both in vitro and in vivo and to explore its underlying mechanism. Read More

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http://dx.doi.org/10.3727/096504018X15321979274728DOI Listing
July 2018
7 Reads
0.920 Impact Factor

GSK-3β Promotes Cell Migration and Inhibits Autophagy by Mediating the AMPK Pathway in Breast Cancer.

Oncol Res 2019 Mar 23;27(4):487-494. Epub 2018 Jul 23.

General Surgery, YouJiang Medical University for Nationalities, Guangxi, P.R. China.

GSK-3β is a versatile protein kinase participating in many reactions. Currently, there is insufficient understanding of its influence on breast cancer (BC). In order to explore its influence on migration and invasion in BC, we investigated its expression in BC cell lines using qRT-PCR and Western blot (WB). Read More

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http://dx.doi.org/10.3727/096504018X15323394008784DOI Listing
March 2019
2 Reads

Efficacy and safety of CalliSpheres® drug-eluting beads transarterial chemoembolization in Barcelona Clinic Liver Cancer stage C patients.

Oncol Res 2018 Jul 13. Epub 2018 Jul 13.

Department of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.

This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients with BCLC stage C liver cancer, after the first cycle of DEB-TACE, 2 (5.1%) and 24 (61. Read More

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http://dx.doi.org/10.3727/096504018X15313896322888DOI Listing
July 2018
17 Reads

Long Noncoding RNA NEAT1 Promotes Growth and Metastasis of Cholangiocarcinoma Cells.

Oncol Res 2018 Jul;26(6):879-888

Department of Biliary Minimally Invasive Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, P.R. China.

Long noncoding RNAs (lncRNAs) are known to play important roles in cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis. We investigated the role of nuclear paraspeckle assembly transcript 1 (NEAT1) lncRNA in promoting CCA. Read More

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http://dx.doi.org/10.3727/096504017X15024935181289DOI Listing
July 2018
3 Reads

Apatinib plus chemotherapy shows clinical activity in advanced NSCLC: a retrospective study.

Oncol Res 2018 Jun 21. Epub 2018 Jun 21.

Department of 1st Division of Thoracic Tumor in Hubei Cancer Hospital, Wuhan City, Hubei Province, China, PRC.

Apatinib is an oral TKI with anti-angiogenesis properties, and it is currently approved for the treatment of advanced gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell lung cancer (NSCLC). Since the combination of chemotherapy and an anti-angiogenesis agent has been shown to be feasible strategy in NSCLC, it is conceivable that a similar approach combining apatinib with chemotherapy may yield clinical activity. Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1528
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http://dx.doi.org/10.3727/096504018X15288447760357DOI Listing
June 2018
9 Reads