1,692 results match your criteria Oncology Research[Journal]


OLFM4 inhibits epithelial-mesenchymal transition and metastatic potential of cervical cancer cells.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Gynecology, Jinan Women and Children's Health Hospital, Jinan, Shandong, 250001, P.R. China.

OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Read More

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http://dx.doi.org/10.3727/096504018X15399955297355DOI Listing
February 2019

Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated By Notch1 Pathway In Murine Mammary Carcinoma.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.

Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Read More

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http://dx.doi.org/10.3727/096504018X15415906335771DOI Listing
February 2019

PHF8 plays an oncogene function in hepatocellular carcinoma formation.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Traditional Chinese Medicine, Jiaozhou People's Hospital, Jiaozhou, Shandong Province, China, 266300.

Hepatocellular carcinoma (HCC) has high morbidity and mortality rates, and the number of new cases and deaths from liver cancer are increasing. However, the details of the regulation in HCC remain largely unknown. Plant Homeodomain Finger protein 8 (PHF8) is a JmjC domain-containing protein. Read More

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http://dx.doi.org/10.3727/096504018X15410353669149DOI Listing
February 2019

Hsa_circ_0003998 promotes chemoresistance via modulation of miR-326 in lung adenocarcinoma cells.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Central Laboratory, Yinzhou People's Hospital, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, China.

Circular RNAs (circRNAs) represent a new class of non-coding RNAs that is involved in the development of cancer. However, little is known about their role in chemoresistance. In the present study, we found that hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines (A549/DTX and H1299/DTX) were upregulated. Read More

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http://dx.doi.org/10.3727/096504018X15420734828058DOI Listing
February 2019

High circ_100053 predicts a poor outcome for chronic myeloid leukemia and is involved in imatinib resistance.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Hematology, Hunan Provincial People's Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, China, 410002.

Chronic myeloid leukemia (CML) is a rare clonal myeloproliferative malignancy, which is caused by a reciprocal translocation between chromosomes 9 and 22 t(9;22) (q34;q11). Altered circle RNAs (circRNAs) could contribute to leukemogenesis. In this study, we aimed to investigate the expression profiling of circRNAs in CML. Read More

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http://dx.doi.org/10.3727/096504018X15412701483326DOI Listing
February 2019

The interaction between lncRNA SNHG1 and miR-140 in regulating growth and tumorigenesis via TLR4/NF-╬║B pathway in cholangiocarcinoma.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.

Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. Read More

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http://dx.doi.org/10.3727/096504018X15420741307616DOI Listing
February 2019

NOTCH3 overexpression and post-transcriptional regulation by miR-150 were associated with EGFR-TKI resistance in lung adenocarcinoma.

Oncol Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, Xuzhou 221009, China.

Acquired resistance remains a key challenge in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) therapy in lung adenocarcinoma (LUAD). Recent studies have shown that Notch signaling is associated with drug resistance. However, its role and possible mechanisms in EGFR-TKI resistance are not yet clear. Read More

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http://dx.doi.org/10.3727/096504018X15372657298381DOI Listing
February 2019
1 Read

ERRATUM.

Oncol Res 2019 Feb;27(2):281-282

Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.

MicroRNA-200a (miR-200a) is frequently downregulated in most cancer types and plays an important role in carcinogenesis and cancer progression. In this study, we determined that miR-200a was downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, consistent with the results of our previous study. Because a previous study suggested that downregulation of miR-200a is correlated with HCC metastasis, we aimed to elucidate the mechanism underlying the role of miR-200a in metastasis in HCC. Read More

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http://dx.doi.org/10.3727/096504019X15476499940873DOI Listing
February 2019
1 Read

1,25(OH)2D3 attenuates IL-1╬▓-induced epithelial to mesenchymal transition through inhibiting the expression of lncTCF7.

Oncol Res 2018 Sep 4. Epub 2018 Sep 4.

Department of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, PR China.

The activated form of vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), regulates numerous cellular processes, including inhibition of cancer progression. IL-1╬▓ has been reported to facilitate cancer development, especially by inducing an epithelial-to-mesenchymal transition (EMT) in several malignant tumors. However, the underlying mechanism of 1,25(OH)2D3 and IL-1╬▓ in colorectal cancer (CRC) still remains largely unknown. Read More

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http://dx.doi.org/10.3727/096504018X15360541345000DOI Listing
September 2018
1 Read

Exosomal miR-1228 from cancer-associated fibroblasts promotes cell migration and invasion of osteosarcoma by directly targeting SCAI.

Oncol Res 2018 Aug 8. Epub 2018 Aug 8.

Department of Orthopedic, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, 215300, P. R. China.

Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. Read More

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http://dx.doi.org/10.3727/096504018X15336368805108DOI Listing
August 2018
1 Read

Clinical characteristics and molecular patterns of RET-rearranged lung cancer in Chinese patients.

Oncol Res 2018 Aug 21. Epub 2018 Aug 21.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features and therapeutic options in RET-rearranged patients remain unclear, especially in Chinese lung cancers. We retrospectively collected 6125 Chinese lung cancer patients who have been profiled using next-generation sequencing (NGS). Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1534
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http://dx.doi.org/10.3727/096504018X15344979253618DOI Listing
August 2018
10 Reads

Astragaloside IV inhibits the progression of non-small cell lung cancer through Akt/GSK-3╬▓/╬▓-catenin pathway.

Oncol Res 2018 Aug 21. Epub 2018 Aug 21.

School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.

Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus, and involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. A cell counting kit (CCK)-8 assay and flow cytometry were performed to investigate cell survival and cell death, and Western blotting was performed to assess protein expression. Read More

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http://dx.doi.org/10.3727/096504018X15344989701565DOI Listing

MicroRNA-152 acts as a tumor suppressor microRNA by inhibiting Kr├╝ppel-like factor 5 in human cervical cancer.

Oncol Res 2018 Aug 21. Epub 2018 Aug 21.

Department of Gynecology, Affiliated Qilu Hospital of Shandong University, No. 127 West Cultural Road, Lixia District, Jinan, Shandong 250012, China.

Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in cervical cancer (CC) is poorly understood. Also, the association between miR-152 and Kr├╝ppel-like factor 5 (KLF5) expression in CC remains unclear. Read More

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http://dx.doi.org/10.3727/096504018X15252202178408DOI Listing
August 2018
1 Read

Anemia is a novel predictive factor for the onset of severe chemotherapy-induced peripheral neuropathy in lymphoma patients receiving rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy.

Oncol Res 2018 May 19. Epub 2018 May 19.

Department of Community Health Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan.

Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Read More

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http://dx.doi.org/10.3727/096504018X15267574931782DOI Listing
May 2018
2 Reads

Efficacy evaluation of imatinib for the treatment of melanoma: evidence from a retrospective study.

Oncol Res 2018 Aug 3. Epub 2018 Aug 3.

Department of Urology & Melanoma, Peking University Cancer Hospital & Institute, Haidian District, Beijing, China, 100142.

Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment is a promising approach in treating advanced melanoma patients harboring c-Kit mutations or amplifications. We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring c-Kit mutations or amplifications. Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1533
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http://dx.doi.org/10.3727/096504018X15331163433914DOI Listing
August 2018
18 Reads
0.920 Impact Factor

miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.

Oncol Res 2019 Feb 3;27(2):253-260. Epub 2018 Aug 3.

Department of Breast Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P.R. China.

miR-1284 has been reported to inhibit tumor growth in some human cancers, including lung cancer, ovarian cancer, and gastric cancer. Whether it regulates breast cancer progression remains elusive. In this study, we found that miR-1284 was downregulated in breast cancer tissues and cell lines compared to normal control cells. Read More

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http://dx.doi.org/10.3727/096504018X15242763477504DOI Listing
February 2019
13 Reads

Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.

Oncol Res 2018 Jul 23. Epub 2018 Jul 23.

Department of Tumor radiotherapy intervention, Xianyang City Central Hospital, Xianyang, Shaanxi, 712000, China.

Non-small cell lung cancer (NSCLC) is the most common lung cancer with 15.9% of predicted 5-year survival rate which represents extremely poor prognosis. In this study, we aimed to investigate the effects of Biochanin A (BIO-A) on NSCLC both in vitro and in vivo and to explore its underlying mechanism. Read More

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http://dx.doi.org/10.3727/096504018X15321979274728DOI Listing
July 2018
3 Reads
0.920 Impact Factor

GSK-3╬▓ promotes cell migration and inhibits autophagy by mediating the AMPK pathway in breast cancer.

Oncol Res 2018 Jul 23. Epub 2018 Jul 23.

General Surgery, YouJiang Medical University for Nationalities, Guangxi, China.

GSK-3╬▓ is a versatile protein kinase participating in many reactions. Currently, there is insufficient understanding of its influence on breast cancer (BC). In order to explore its influence on migration and invasion in BC, we investigated its expression in BC cell lines using qRT-PCR and western blot (WB). Read More

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http://dx.doi.org/10.3727/096504018X15323394008784DOI Listing
July 2018
2 Reads

Efficacy and safety of CalliSpheres® drug-eluting beads transarterial chemoembolization in Barcelona Clinic Liver Cancer stage C patients.

Oncol Res 2018 Jul 13. Epub 2018 Jul 13.

Department of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.

This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients with BCLC stage C liver cancer, after the first cycle of DEB-TACE, 2 (5.1%) and 24 (61. Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1531
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http://dx.doi.org/10.3727/096504018X15313896322888DOI Listing
July 2018
8 Reads

Long Noncoding RNA NEAT1 Promotes Growth and Metastasis of Cholangiocarcinoma Cells.

Oncol Res 2018 Jul;26(6):879-888

Department of Biliary Minimally Invasive Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, P.R. China.

Long noncoding RNAs (lncRNAs) are known to play important roles in cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis. We investigated the role of nuclear paraspeckle assembly transcript 1 (NEAT1) lncRNA in promoting CCA. Read More

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http://dx.doi.org/10.3727/096504017X15024935181289DOI Listing
July 2018
3 Reads

Apatinib plus chemotherapy shows clinical activity in advanced NSCLC: a retrospective study.

Oncol Res 2018 Jun 21. Epub 2018 Jun 21.

Department of 1st Division of Thoracic Tumor in Hubei Cancer Hospital, Wuhan City, Hubei Province, China, PRC.

Apatinib is an oral TKI with anti-angiogenesis properties, and it is currently approved for the treatment of advanced gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell lung cancer (NSCLC). Since the combination of chemotherapy and an anti-angiogenesis agent has been shown to be feasible strategy in NSCLC, it is conceivable that a similar approach combining apatinib with chemotherapy may yield clinical activity. Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1528
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http://dx.doi.org/10.3727/096504018X15288447760357DOI Listing
June 2018
9 Reads

Regorafenib-Induced Hand-Foot Skin Reaction is More Severe on the Feet than on the Hands.

Oncol Res 2018 Jun 18. Epub 2018 Jun 18.

Department of Pharmacy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.

Regorafenib is a multikinase inhibitor for the treatment of metastatic colorectal cancer. Regorafenib-induced hand-footskin reaction (HFSR) is a common side effect during treatment. The reported frequency of HFSR was 80% (Grade 3: 28%) of the Japanese subpopulation in the CORRECT trial; however, more detailed data regarding HFSR in terms of onset and sites of susceptibility are unclear. Read More

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http://dx.doi.org/10.3727/096504018X15291727589740DOI Listing
June 2018
4 Reads

The biological function of Hepatitis B virus X protein in hepatocellular carcinoma.

Oncol Res 2018 Jun 1. Epub 2018 Jun 1.

Department of Biliary-Pancreatic Minimally Invasive Surgery, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515041, China.

Hepatocellular carcinoma (HCC) is one of the major malignant tumors leading to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by HBV X gene, is a significant factor that promotes HBV related HCC, although the exact molecular mechanism remains unclear. Read More

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http://dx.doi.org/10.3727/096504018X15278771272963DOI Listing
June 2018
6 Reads

Bufalin induces apoptosis and improves the sensitivity of human glioma stem-like cells to temozolamide.

Oncol Res 2018 May 24. Epub 2018 May 24.

Department of Neurosurgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning Province, P.R. China.

Glioma is the most common malignant tumor of the central nervous system and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) extracted from toad venom. Previous studies revealed that bufalin exerted inhibitory effects on a variety of tumor cells. Read More

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http://dx.doi.org/10.3727/096504018X15270916676926DOI Listing
May 2018
3 Reads

NLRP3 promotes glioma cell proliferation and invasion via the interleukin-1╬▓/NF-╬║B p65 signals.

Oncol Res 2018 May 16. Epub 2018 May 16.

Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, PR China.

Due to the characteristics of high invasiveness, relapse and poor prognosis, the management of malignant gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is a crucial component of the NLRP3 inflammasome, a multiprotein complex that can triggercaspase-1/interleukin-1 (IL-1) mediated inflammatory response once activated and participates in the pathogeny of diverse inflammatory diseases as well as cancers. Herein, we examined the function of NLRP3 in the development of glioma. Read More

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http://dx.doi.org/10.3727/096504018X15264647024196DOI Listing
May 2018
2 Reads

Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells.

Authors:
Li Zhu Lijun Xue

Oncol Res 2018 Apr 3. Epub 2018 Apr 3.

Madonna University, Livonia, Michigan, USA.

Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus, we investigated how kaempferol suppresses the growth of BC cells. Read More

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http://dx.doi.org/10.3727/096504018X15228018559434DOI Listing
April 2018
1 Read

Safety and efficacy analysis of DEB-TACE treatment in elderly patients with hepatocellular carcinoma: a comparative cohort study.

Oncol Res 2018 May 8. Epub 2018 May 8.

Department of Interventional Radiology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, P.R. China.

The aim of this study was to explore the difference of liver function change, safety profiles and efficacy of drug-eluting bead transarterial chemoembolization (DEBTACE) therapy between elderly and middle-aged hepatocellular carcinoma (HCC) patients. 91 HCC patients were enrolled in this prospective cohort study. They were treated by DEB-TACE therapy and divided into elderly group (age >= 65 years, n=30) and middle-aged group (age < 65 years, n=61), liver function, safety profiles and treatment response were recorded. Read More

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http://dx.doi.org/10.3727/096504018X15223171140640DOI Listing
May 2018
6 Reads

MicroRNA-411 inhibits cervical cancer progression by directly targeting STAT3.

Oncol Res 2018 May 1. Epub 2018 May 1.

Department of Obstetrics and Gynecology, Tianjin Hospital, Tianjin 300211, China.

Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths inwomen around the world. Substantial evidence has proved that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Read More

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http://dx.doi.org/10.3727/096504018X15247361080118DOI Listing
May 2018
3 Reads

Overexpression of miR-1283 inhibits cell proliferation and invasion of glioma cells by targeting ATF4.

Oncol Res 2018 May 1. Epub 2018 May 1.

Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China.

It is well known that activating transcription factor 4 (ATF4) expression is closely associated with progression of many cancers. And we found that miR-1283 could directly target the ATF4. However, the precise mechanisms of miR-1283 in glioma have not been well clarified. Read More

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http://dx.doi.org/10.3727/096504018X15251282086836DOI Listing
May 2018
2 Reads

MiR-185 inhibits cell proliferation and invasion of non-small cell lung cancer by targeting KLF7.

Oncol Res 2018 May 1. Epub 2018 May 1.

Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City, China.

MicroRNAs are short endogenous non-coding RNAs, which can frequently emerge as regulators in many cancer types. It wasdemonstrated in the research that miR-185 expression levels were remarkably down-regulated in NSCLC tissues than in adjacent normal tissues. Lower miR-185 expression levels were definitely associated with lymph node metastasis. Read More

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http://dx.doi.org/10.3727/096504018X15247341491655DOI Listing
May 2018
4 Reads

MiR-150 suppresses tumor growth in melanoma through downregulation of MYB.

Oncol Res 2018 Apr 24. Epub 2018 Apr 24.

Department of Oncology, Shanxian Central Hospital, Heze 274300, Shandong Province, China.

MiR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Read More

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http://dx.doi.org/10.3727/096504018X15228863026239DOI Listing
April 2018
1 Read

LncRNA MNX1-AS1 promotes glioblastoma progression through inhibition of miR-4443.

Oncol Res 2018 Apr 20. Epub 2018 Apr 20.

Department of Neurology, Shengjing Hospital, Affiliated Hospital of China Medical University, Shenyang 110004, China.

Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. LncRNA MNX1-AS1has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1522
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http://dx.doi.org/10.3727/096504018X15228909735079DOI Listing
April 2018
32 Reads

Experimental and In Silico Analysis of Cordycepin and its Derivatives as Endometrial Cancer Treatment.

Oncol Res 2019 Feb 19;27(2):237-251. Epub 2018 Apr 19.

School of Health Sciences, Macao Polytechnic Institute, Macao, P.R. China.

The aim of this study was to investigate the inhibition effects of cordycepin and its derivatives on endometrial cancer cell growth. Cytotoxicity MTT assays, clonogenic assays, and flow cytometry were used to observe the effects on apoptosis and regulation of the cell cycle of Ishikawa cells under various concentrations of cordycepin, cisplatin, and combinations of the two. Validated in silico docking simulations were performed on 31 cordycepin derivatives against adenosine deaminase (ADA) to predict their binding affinities and hence their potential tendency to be metabolized by ADA. Read More

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http://dx.doi.org/10.3727/096504018X15235274183790DOI Listing
February 2019
5 Reads

Pokemon/miR-137 auto-regulatory circuit promotes the progression of renal carcinoma.

Oncol Res 2018 Apr 19. Epub 2018 Apr 19.

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People's Republic of China.

Renal carcinoma greatly threatens human health, but the involved molecular mechanisms are far from complete understanding. As a master oncogene driving the initiation of many other cancers, Pokemon has not been established to be associated with renal cancer. Our data revealed that Pokemon is highly expressed in renal carcinoma specimen and cell lines, compared with normal cells. Read More

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http://dx.doi.org/10.3727/096504018X15231148037228DOI Listing
April 2018
3 Reads

Long noncoding RNA LINC01296 harbors miR-21a to regulate colon carcinoma proliferation and invasion.

Oncol Res 2018 Apr 19. Epub 2018 Apr 19.

Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical College, Jining, Shandong, 272000, China.

Increasing evidences have demonstrated that aberrant expressions of long non-coding RNAs (lncRNAs) are closely correlated to various malignancies, as well as colon carcinoma (CC). The aim of this study was to investigate the role of lncRNA long intergenic noncoding RNA 001296 (LINC01296) in tumorigenesis of CC. The result of the quantitative real-time polymerase chain reaction (qRT-PCR) demonstrated that LINC01296 was upregulated in CC cancerous tissues and cell lines compared to adjacent normal tissue and normal liver cell lines. Read More

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http://dx.doi.org/10.3727/096504018X15234931503876DOI Listing
April 2018
6 Reads
0.920 Impact Factor

LncRNA BCAR4 increases viability, invasion and migration non-small cell lung cancer cells by targeting glioma-associated oncogene 2().

Oncol Res 2018 Apr 3. Epub 2018 Apr 3.

Department of Clinical Laboratory, the Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang, China.

Objective: This study was aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-smallcell lung cancer (NSCLC) cells.

Methods: qRTPCR was used to determine the expression of lncRNA BCAR4 and downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and western blot were employed to measure the expression of downstream proteins. Read More

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http://dx.doi.org/10.3727/096504018X15220594629967DOI Listing
April 2018
5 Reads

MiR-455 functions as a tumor suppressor through targeting GATA6 in colorectal cancer.

Oncol Res 2018 Apr 3. Epub 2018 Apr 3.

Cancer Biotherapy Center and Oncology Department, Baotou Tumor Hospital, Clinical Oncology of Baotou Medical College, No.18 United street, Qingshan District, Baotou, Inner Mongolia 014030, P. R. China.

Emerging evidence indicates microRNAs (miRNAs) are often aberrantly expressed in human cancers. Meanwhile, the importance of miRNAs in regulating multiplies cellular biological processes has been appreciated. The aim of this study was to investigate the significance of miR-455 and identify its possible mechanism in regulating colorectal cancer (CRC) progression. Read More

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http://dx.doi.org/10.3727/096504018X15220579006875DOI Listing
April 2018
5 Reads

MicroRNA-495 inhibits proliferation, metastasis and promotes apoptosis by targeting Twist1 in gastric cancer cells.

Oncol Res 2018 Apr 3. Epub 2018 Apr 3.

Department of General Surgery, Qingdao Municipal Hospital, Qingdao 266071, China.

Recently, microRNAs (miRNAs) have reported to participate in multiple biological processes. However, the effects of miR-495 on gastric cancer (GC) remain unclear. The purpose of this study is to explore the functions of miR-495 in GC cells proliferation, metastasis and apoptosis. Read More

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http://dx.doi.org/10.3727/096504018X15223159811838DOI Listing
April 2018
49 Reads

miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8.

Oncol Res 2019 Feb 3;27(2):261-268. Epub 2018 Apr 3.

Department of Respiratory Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.

miR-223-5p has been demonstrated to regulate the development and progression of various cancers, such as hepatocellular carcinoma, breast cancer, and gastric carcinoma. However, the role of miR-223-5p in non-small cell lung cancer (NSCLC) requires further investigation. In this study, we found that the expression of miR-223-5p was significantly downregulated in NSCLC tissues and cell lines. Read More

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http://www.ingentaconnect.com/content/10.3727/096504018X1521
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http://dx.doi.org/10.3727/096504018X15219188894056DOI Listing
February 2019
7 Reads

Curcumin suppress the growth of hepatocellular carcinoma via down-regulating .

Oncol Res 2018 Apr 3. Epub 2018 Apr 3.

Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

The aim of this study is to investigate the pharmacological effect of curcumin on hepatocellular carcinoma (HCC) Huh7 and PLC cells and to explore its mechanism in the pathological process by screening possible target genes. MTT assay was used to detect the effect of curcumin on the growth of Huh7 and PLC cells. The inhibitory effect was found to be in a time- and dose- dependent manner, and the cytoplasm was shrunk with round or elliptic morphology. Read More

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http://dx.doi.org/10.3727/096504018X15219173841078DOI Listing
April 2018
7 Reads

Kinesin Motor Protein KIFC1 Is a Target Protein of miR-338-3p and Is Associated With Poor Prognosis and Progression of Renal Cell Carcinoma.

Oncol Res 2018 Dec 21;27(1):125-137. Epub 2018 Mar 21.

Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China.

KIFC1 (kinesin family member C1) plays a critical role in clustering of extra centrosomes in various cancer cells and thus could be considered as a promising therapeutic target. However, whether KIFC1 is involved in the procession of renal cell carcinoma (RCC) still remains unclear. In this study, we found that KIFC1 was upregulated in RCC tissues and is responsible for RCC tumorigenesis (ÔÇë<ÔÇë0. Read More

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http://dx.doi.org/10.3727/096504018X15213115046567DOI Listing
December 2018
20 Reads
1 Citation
0.920 Impact Factor

MiR-632 promotes laryngeal carcinoma cell proliferation, migration and invasion through negative regulation of GSK3╬▓.

Oncol Res 2018 Mar 21. Epub 2018 Mar 21.

Department of Oncology, Liaocheng Tumor Hospital, Liaocheng, Shandong 250000, China.

Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence hasdemonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. MiR-632, a tumor-related miRNA, has been reported to be dysregulated and implicated in human malignancies; however, its biological role in laryngeal carcinoma remains to be elucidated. Read More

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http://dx.doi.org/10.3727/096504018X15213142076069DOI Listing
March 2018
5 Reads

MicroRNA 615-3p Inhibits the Tumor Growth and Metastasis of NSCLC via Inhibiting IGF2.

Oncol Res 2019 Feb 21;27(2):269-279. Epub 2018 Mar 21.

Department of Cardiothoracic Surgery, Binzhou Central Hospital, Binzhou, Shandong, P.R. China.

MicroRNAs are essential regulators of cancer-associated genes at the posttranscriptional level, and their expression is altered in cancer tissues. Herein we sought to identify the regulation of miR-615-3p in NSCLC progression and its mechanism. miR-615-3p expression was significantly downregulated in NSCLC tissue compared to control normal tissue. Read More

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http://dx.doi.org/10.3727/096504018X15215019227688DOI Listing
February 2019
6 Reads

MicroRNA-1277 inhibits proliferation and migration of hepatocellular carcinoma HepG2 cells by targeting and suppressing BMP4 expression and reflects the significant indicative role in hepatocellular carcinoma pathology and diagnosis after magnetic resonance imaging assessment.

Oncol Res 2018 Mar 21. Epub 2018 Mar 21.

Department of Radiology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, China.

Our study aimed to investigate the roles and possible regulatory mechanism of miR-1277 in the development of hepatocellular carcinoma (HCC). HCC patients were identified from patients who were diagnosed with focal liver lesions using magnetic resonance imaging (MRI). The expression levels of miR-1277 in the serum of HCC patients and HepG2 cells were measured. Read More

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http://dx.doi.org/10.3727/096504018X15213058045841DOI Listing
March 2018
23 Reads

miR-449a Suppresses Tumor Growth, Migration, and Invasion in Non-Small Cell Lung Cancer by Targeting a HMGB1-Mediated NF-╬║B Signaling Pathway.

Oncol Res 2019 Feb 21;27(2):227-235. Epub 2018 Mar 21.

Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China.

MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The dysregulation of miR-449a is found in many types of malignancies and is associated with tumor growth, migration, and invasion. However, its expression and function in non-small cell lung cancer (NSCLC) still remains unclear. Read More

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http://dx.doi.org/10.3727/096504018X15213089759999DOI Listing
February 2019
14 Reads

TRIM14 promotes breast cancer cell proliferation by inhibiting apoptosis.

Oncol Res 2018 Mar 21. Epub 2018 Mar 21.

Department of General Surgery, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, 201203, PR China.

Tripartite motif-containing 14 (TRIM14) abnormally expressed in several human cancers. However, the function and expression of TRIM14 in human breast cancer were still largely unknown. To understand biological function of TRIM14 in breast cancer, we measured expression level of TRIM14. Read More

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http://dx.doi.org/10.3727/096504018X15214994641786DOI Listing
March 2018
4 Reads

MicroRNA-338-3p Inhibits Proliferation and Promotes Apoptosis of Multiple Myeloma Cells Through Targeting Cyclin-Dependent Kinase 4.

Oncol Res 2018 Dec 21;27(1):117-124. Epub 2018 Mar 21.

Clinical Laboratory, the First Affiliated Hospital, Jilin University, Chaoyang District, Changchun, P.R. China.

MicroRNA-338-3p (miR-338-3p) has been reported to be a tumor suppressor in multiple cancer types. However, the biological role of miR-338-3p and its underlying mechanism in multiple myeloma (MM) remain unclear. In the present study, we investigated the biological role and potential of miR-338-3p in MM. Read More

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http://dx.doi.org/10.3727/096504018X15213031799835DOI Listing
December 2018
4 Reads
0.920 Impact Factor

Long Noncoding RNA FOXC2-AS1 Predicts Poor Survival in Breast Cancer Patients and Promotes Cell Proliferation.

Oncol Res 2019 Feb 21;27(2):219-226. Epub 2018 Mar 21.

Department of Breast Surgery, the Affiliated Hospital of Guizhou Medical University, Guizhou, P.R. China.

Breast cancer (BC) is the most common malignant tumor in women. Recently, long noncoding RNAs (lncRNAs) have been proposed as critical regulators in biological processes, including tumorigenesis. FOXC2-AS1, a single antisense oligonucleotide RNA transcribed from the negative strand of forkhead box protein C2 (FOXC2), has been identified as an oncogene in osteosarcoma. Read More

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http://dx.doi.org/10.3727/096504018X15213126075068DOI Listing
February 2019
5 Reads

Thrombospondin 1 Triggers Osteosarcoma Cell Metastasis and Tumor Angiogenesis.

Oncol Res 2019 Feb 14;27(2):211-218. Epub 2018 Mar 14.

Affiliated People's Hospital of Guizhou Medical University, Guiyang, P.R. China.

Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumor effects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here we demonstrated that thrombospondin 1 (TSP-1) is a potent inhibitor of the growth and metastasis of the osteosarcoma cell line MG-63. Read More

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http://dx.doi.org/10.3727/096504018X15208993118389DOI Listing
February 2019
4 Reads

Luteolin suppresses teratoma cells growth and induces cell apoptosis via inhibiting Bcl-2.

Oncol Res 2018 Mar 14. Epub 2018 Mar 14.

Department of Pediatric Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2 Road Binzhou City, Shandong Province, China.

Luteolin, which was discovered in plant foods, has out range of therapeutic actions. In order to examine the potentialeffects of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was used as in vitro and in vivo model. It was confirmed that the luteolin could inhibit the proliferation and colony formation of PA-1 cells in vitro. Read More

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http://dx.doi.org/10.3727/096504018X15208986577685DOI Listing
March 2018
6 Reads