3,374,365 results match your criteria Oncology & Hematology Review [Journal]


Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, Amsterdam, The NetherlandsRadiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam.

Multimodality treatment has advanced the outcome of esophageal adenocarcinoma (EAC), but overall survival remains poor. Therapeutic pressure activates effective resistance mechanisms and we characterized these mechanisms in response to the currently used neoadjuvant treatment against EAC; carboplatin, paclitaxel and radiotherapy. We developed an in vitro approximation of this regimen and applied it to primary patient-derived cultures. Read More

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http://dx.doi.org/10.1002/ijc.32364DOI Listing

PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

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http://dx.doi.org/10.1002/ijc.32366DOI Listing

NK and T cell subsets in malignant mesothelioma patients: baseline pattern and changes in the context of anti-CTLA-4 therapy.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK cell subsets and their recognition of mesothelioma cells remains to be explored. We used RNA expression data of MM biopsies derived from the cancer genome atlas to evaluate the immune cell infiltrates. Read More

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http://dx.doi.org/10.1002/ijc.32363DOI Listing

Fisetin and 5-Fluorouracil: Effective Combination for PIK3CA-Mutant Colorectal Cancer.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

The normal colon epithelium is transformed into its neoplastic counterpart through a series of genetic alterations in driver genes including activating mutations in PIK3CA. Treatment often involves surgery followed by 5-fluorouracil (5-FU) based therapy, which has limited efficiency and serious side effects. We sought to determine whether fisetin, a dietary flavonoid, alone or in combination with 5-FU affected tumorigenesis in the mammalian intestine. Read More

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http://dx.doi.org/10.1002/ijc.32367DOI Listing

Successful use of an immune checkpoint inhibitor in a patient with myasthenia gravis in remission.

Muscle Nerve 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine IV, Hematology and Oncology, University of Halle.

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http://dx.doi.org/10.1002/mus.26495DOI Listing

Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

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http://dx.doi.org/10.1002/ijc.32365DOI Listing

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.

In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. Read More

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http://dx.doi.org/10.1002/ijc.32361DOI Listing

The Low-Cost, Long-Term Indwelling Pleural Catheter (LunGO): An Inexpensive and Effective Alternative for the Management of Dyspnea Associated with Malignant Pleural Effusions.

Respiration 2019 Apr 24:1-6. Epub 2019 Apr 24.

Thoracic Surgeon at Hospital Santa Marcelina de Itaquera, São Paulo, Brazil.

Background: A malignant pleural effusion (MPE) in patients with cancer is evidence of the underlying disease progression, resulting in many symptoms, and may lead to hospitalization. The treatment options include talc pleurodesis (TP) or the implantation of an indwelling pleural catheter. The costs of the latter approach are often seen to be inhibitive for the Brazilian and other emerging markets' public health system. Read More

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http://dx.doi.org/10.1159/000498971DOI Listing
April 2019
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Systemic Treatment Options for Carcinoid Syndrome: A Systematic Review.

Oncology 2019 Apr 24:1-17. Epub 2019 Apr 24.

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.

Background: Carcinoid syndrome symptoms significantly reduce quality of life in patients with neuroendocrine tumors. Evidence supporting the use of somatostatin analogues in carcinoid syndrome symptom control dates back 30 years. The introduction of new treatment options for carcinoid syndrome, such as telotristat ethyl in 2017, highlights the need for a review of high-level evidence of new and established systemic treatments. Read More

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http://dx.doi.org/10.1159/000499049DOI Listing

First clinical retrospective investigation of limited projection CBCT for lung tumor localization in patients receiving SBRT treatment.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Radiation Oncology, Duke University Medical Center, PO Box 3295, Durham, NC 27710-3295, USA, Durham, North Carolina, UNITED STATES.

Purpose: To clinically investigate the limited-projection CBCT (LP-CBCT) technology for daily positioning of patients receiving breath-hold lung SBRT radiation treatment and to investigate the feasibility of reconstructing fast 4D-CBCT from 1 min 3D-CBCT scan.
 Method: Eleven patients who underwent breath-hold lung SBRT radiation treatment were scanned daily with on-board full-projection CBCT (CBCT) using half-fan scan. A subset of the CBCT projections and the prior planning CT were used to estimate the LP-CBCT images using the weighted free-form deformation method. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c0cDOI Listing

Dosimetric impact of esophagus motion in single fraction spine stereotactic body radiotherapy.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, UNITED STATES.

Nine patients with single fraction spinal stereotactic body radiation therapy (SBRT) treatment were identified to assess both the intra fraction and daily esophageal motion and associated dosimetric deviation in spinal SBRT. We performed a chained deformable registration of 4-D CT phase images to estimate the intra fraction motion magnitude of the esophagus in a breathing cycle. The intra fraction esophageal motion mostly exhibited in the superior-inferior direction with the total motion magnitude increased from the T1 (0. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c2bDOI Listing

Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis.

Cell Rep 2019 Apr;27(4):1277-1292.e7

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based approach, which leverages the transcriptome of xenografts and distinguishes tumor cell and stromal gene expression with improved sensitivity and accuracy. Our data reveal shifts in epithelial and neuronal-like lineage programs in malignant cells as they adapt to the brain TME and the reciprocal neuroinflammatory response of the stroma. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.085DOI Listing

In Situ Modification of Tissue Stem and Progenitor Cell Genomes.

Cell Rep 2019 Apr;27(4):1254-1264.e7

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address:

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, we use a sensitive Cre/lox fluorescent reporter system to test the efficiency of genome modification following in vivo transduction by adeno-associated viruses (AAVs) in tissue stem and progenitor cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.105DOI Listing

Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
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http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
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Companion diagnostic tests for treatment of lung cancer patients: what are the current and future challenges?

Expert Rev Mol Diagn 2019 Apr 24. Epub 2019 Apr 24.

b Aix Marseille University , CRCM, INSERM, CNRS, AP-HM, Multidisciplinary Oncology and Therapeutic Innovations Department , Chemin des Bourrely, 13015 , Marseille , France .

Introduction: Companion diagnostic tests (CDXs) are considered mandatory for decision making for treatment with targeted therapies in thoracic oncology. The emergence of immunotherapy has also given rise to the development of CDXs. Some CDXs, in particular PD-L1 immunohistochemistry tests, have been questioned and re-examined for use with new combination therapies that are being evaluated in clinical trials. Read More

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http://dx.doi.org/10.1080/14737159.2019.1611426DOI Listing

Scissor haemorrhoidectomy under perineal anaesthetic infiltration as a day case procedure - video vignette.

Colorectal Dis 2019 Apr 24. Epub 2019 Apr 24.

Departament of Surgical oncology, Institute of Oncology, Vilnius University, Clinic of Internal, Family Medicine and Oncology, Faculty of Medicine, Vilnius, Lithuania.

Hemorrhoids are common anorectal disease [1]. Patients with Grade III-IV prolapsed hemorrhoids or after failed conservative are considered for excisional hemorrhoidectomy. Surgical technique At our department all patients with Grade III or IV symptomatic hemorrhoids undergo closed (as described by Fergusson) scissor hemorrhoidectomy under perineal anesthetic infiltration [2], with removal of the two classical piles at 3 and 11. Read More

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http://dx.doi.org/10.1111/codi.14656DOI Listing

Heterozygosity mapping for human dominant trait variants.

Hum Mutat 2019 Apr 24. Epub 2019 Apr 24.

Laboratory of Statistical Genetics, Rockefeller University, New York, New York.

Homozygosity mapping is a well-known technique to identify runs of homozygous variants that are likely to harbor genes responsible for autosomal recessive disease, but a comparable method for autosomal dominant traits has been lacking. We developed an approach to map dominant disease genes based on heterozygosity frequencies of sequence variants in the immediate vicinity of a dominant trait. We demonstrate through theoretical analysis that DNA variants surrounding an inherited dominant disease variant tend to have increased heterozygosity compared with variants elsewhere in the genome. Read More

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http://dx.doi.org/10.1002/humu.23765DOI Listing

Infiltrating CD4+ T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling.

Prostate 2019 Apr 24. Epub 2019 Apr 24.

Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing, China.

Background: Chemotherapy with Docetaxel (Doc) is efficient in a subset of prostate cancer (PCa) cases; however, most patients ultimately develop resistance to Docetaxel. The tumor immune microenvironment and secreted cytokines play a substantial role in development of resistance to chemotherapy. Our previous study has demonstrated that CD4+ T cells in prostate tumor microenvironment contribute to PCa progression; meanwhile, we found increased CD4+ T-cell infiltration in tumor area after Doc treatment; however, their effects on PCa chemosensitivity remain unclear. Read More

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http://dx.doi.org/10.1002/pros.23810DOI Listing

Mentoring stages: A study of undergraduate mentoring in palliative medicine in Singapore.

PLoS One 2019 24;14(4):e0214643. Epub 2019 Apr 24.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

Background: Mentoring nurtures a mentee's personal and professional development. Yet conflation of mentoring approaches and a failure to contend with mentoring's nature makes it difficult to study mentoring processes and relationships. This study aims to understand of mentee experiences in the Palliative Medicine Initiative (PMI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214643PLOS

Mutational landscape of canine B-cell lymphoma profiled at single nucleotide resolution by RNA-seq.

PLoS One 2019 24;14(4):e0215154. Epub 2019 Apr 24.

Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Padua, Italy.

The genomic landscape in human B-cell lymphoma has revealed several somatic mutations and potentially relevant germline alterations affecting therapy and prognosis. Also, mutations originally described as somatic aberrations have been shown to confer cancer predisposition when occurring in the germline. The relevance of mutations in canine B-cell lymphoma is scarcely known and gene expression profiling has shown similar molecular signatures among different B-cell histotypes, suggesting other biological mechanisms underlining differences. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215154PLOS

Long intervals between two doses of HPV vaccines and magnitude of the immune response: A post-hoc analysis of two clinical trials.

Hum Vaccin Immunother 2019 Apr 24. Epub 2019 Apr 24.

c Division of High-Consequence Pathogens and Pathology , Centers for Disease Control and Prevention , Atlanta , USA.

The objective of this analysis was to compare the anti-HPV GMTs and their distribution after a 6- month or a 3-8 year interval between two HPV vaccine doses. The results from two clinical trials, conducted by the same team in the same region, with serological assays performed at the same laboratory using the same ELISA methodology were compared. In the first study, 173 9-10 year-old girls and boys received two doses of 9vHPV vaccine at a 6-month interval; in the second study, 31 girls vaccinated with one dose of 4vHPV at the age of 9-14 years received a dose of 9vHPV 3-8 years later (mean 5. Read More

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http://dx.doi.org/10.1080/21645515.2019.1605278DOI Listing

Upregulated MicroRNA-141 Suppresses Epithelial-Mesenchymal Transition and Lymph Node Metastasis via HOXC6-Dependent TGF-β Signaling Pathway in Laryngeal Cancer.

Am J Physiol Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine Oncology, Linyi People's Hospital, Linyi 276003, P.R. China.

Laryngeal cancer ranks as the foremost head and neck malignant tumor. The abnormal expression of microRNAs (miRNAs) has been reported due to its role in cancer development with ability to regulate proliferation and apoptosis of cancer cells. This study investigated the roles of microRNA-141 (miR-141), Homeobox C6 (HOXC6), and the transforming growth factor-β (TGF-β) signaling pathway in epithelial-mesenchymal transition (EMT) and lymph node metastasis in laryngeal cancer. Read More

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http://dx.doi.org/10.1152/ajpcell.00291.2018DOI Listing

Applying the Paris system for reporting urine cytology to challenging cytology cases.

Diagn Cytopathol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology, Northwell Health, Lake Success, New York.

Background: Implementing the Paris system for reporting urine cytology (TPS) can substantiate atypical diagnosis while improving standardization and risk stratification. This study evaluates its performance and reproducibility in challenging cases and examines whether focused education of morphological features can improve outcomes.

Methods: In our prior study, urine cytology cases diagnosed as "atypical" with surgical follow-up were used. Read More

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http://dx.doi.org/10.1002/dc.24166DOI Listing

Obstruction is associated with perineural invasion in T3/T4 colon cancer.

Colorectal Dis 2019 Apr 24. Epub 2019 Apr 24.

Department of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Aim: Perineural invasion (PNI) is a risk factor for recurrence and metastasis, and consequently leads to decreased survival in patients with various malignancy. Recent studies showed that stent placement in obstructive colon cancer increases the frequency of PNI. We hypothesized that mechanical stress including obstruction itself may be associated with PNI. Read More

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http://dx.doi.org/10.1111/codi.14655DOI Listing

Lactate dehydrogenase and baseline markers associated with clinical outcomes of advanced esophageal squamous cell carcinoma patients treated with camrelizumab (SHR-1210), a novel anti-PD-1 antibody.

Thorac Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: A small proportion of patients with advanced esophageal squamous cell carcinoma (ESCC) could benefit from immune checkpoint inhibitors; however, reliable peripheral blood biomarkers for outcomes of anti-PD-1 immunotherapy in ESCC have not been identified.

Methods: The data of 43 patients in the ESCC cohort of a phase I trial at our center were retrospectively reviewed. All patients were administered intravenous camrelizumab (SHR-1210), a novel anti-PD-1 antibody, at doses of 60 mg, 200 mg, or 400 mg (4-week interval after first dose followed by a 2-week schedule) until disease progression or intolerable toxicity. Read More

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http://dx.doi.org/10.1111/1759-7714.13083DOI Listing

Localized RNA interference therapy to eliminate residual lung cancer after incomplete microwave ablation.

Thorac Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Minimally Invasive Interventional Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Background: This study evaluated the safety and efficacy of localized injection of polyethylene glycol (PEG)-hyperbranched polyethyleneimine (PEI)-EGFR-small interfering RNA (siRNA) nanocomposites as a treatment for residual lung cancer after incomplete microwave ablation (MWA).

Methods: Human lung cancer cell lines with high and low EGFR expression were selected for the study. The effects of PEG-PEI-EGFR-siRNA nanocomposite transfection on the proliferation, migration, and apoptosis of lung cancer cells were verified. Read More

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http://dx.doi.org/10.1111/1759-7714.13079DOI Listing

miR-144 reverses cisplatin resistance in cervical cancer via targeting LHX2.

J Cell Biochem 2019 Apr 24. Epub 2019 Apr 24.

Department of Radiation Oncology, First Hospital of Xi'an Jiaotong Univesity, Xi'an, Shaanxi, China.

Mounting evidence showed that microRNAs involve in development and chemoresistance of various human cancers. We explored the roles and mechanisms of miR-144 in resistance to cisplatin (CDDP) of cervical cancer cells. miR-144 and LIM homeobox 2 (LHX2) expression in CDDP-resistant and the parental cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis, respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28763
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http://dx.doi.org/10.1002/jcb.28763DOI Listing
April 2019
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microRNA-messenger RNA regulatory network of esophageal squamous cell carcinoma and the identification of miR-1 as a biomarker of patient survival.

J Cell Biochem 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Emerging evidence indicates that microRNAs (miRNAs) play an important role in tumor carcinogenesis and progression by targeting gene expression. The goal of this study was to comprehensively analyze the vital functional miRNAs and their target genes in esophageal squamous cell carcinoma (ESCC) and to explore the clinical significance and mechanisms of miR-1 in ESCC. First, the miRNA and messenger RNA (mRNA) expression profiles of ESCC were determined with microarray technology. Read More

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http://dx.doi.org/10.1002/jcb.28166DOI Listing

A bypass mechanism of abiraterone-resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling.

Prostate 2019 Apr 24. Epub 2019 Apr 24.

Department of Urology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Intratumoral steroidogenesis and its potential relevance in castration-resistant prostate cancer (CRPC) and in cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)-inhibitor treated hormone-naïve and patients with CRPC are not well established. In this study, we tested if substrates for de novo steroidogenesis accumulating during CYP17A1 inhibition may drive cell growth in relevant preclinical models.

Methods: PCa cell lines and their respective CRPC sublines were used to model CRPC in vitro. Read More

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http://dx.doi.org/10.1002/pros.23799DOI Listing

Hepatitis B core antigen can regulate NLRP3 inflammasome pathway in HepG2 cells.

J Med Virol 2019 Apr 24. Epub 2019 Apr 24.

Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatitis B virus(HBV) has four open reading frames (ORFs) of which ORF C is consists of the pre Core and Core genes encodes the Hepatitis B core antigen (HBcAg) and Hepatitis B e antigen (HBeAg). Studies have shown that HBeAg significantly inhibits the NLRP3 inflammasome activation and IL-1β production. However, the role of HBcAg and ORF C proteins (in this paper, ORF C proteins = HBcAg + HBeAg) were remain unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25490
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http://dx.doi.org/10.1002/jmv.25490DOI Listing
April 2019
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Stage I-III colon cancer patients with tumor deposits behave similarly to stage IV patients. Cross-section analysis of 392 patients.

J Surg Oncol 2019 Apr 24. Epub 2019 Apr 24.

Surgical Oncology, Instituto Nacional de Cancerología, Mexico, Mexico.

Background And Objectives: Tumor deposits (TDs) are associated with adverse prognostic factors and decreased survival in colorectal cancer. However, controversy exists regarding their definition, evaluation, and staging categories. This study aimed to determine the survival and recurrence impact of the TD in colon adenocarcinomas; and to determine if TD patients behave similarly to stage IV patients. Read More

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http://dx.doi.org/10.1002/jso.25482DOI Listing
April 2019
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National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer.

Cancer 2019 Apr 24. Epub 2019 Apr 24.

Clinical Radiation Oncology Branch, Radiation Research Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Colorectal cancer (CRC) represents a major public health problem as the second leading cause of cancer-related mortality in the United States. Of an estimated 140,000 newly diagnosed CRC cases in 2018, roughly one-third of these patients will have a primary tumor located in the distal large bowel or rectum. The current standard-of-care approach includes curative-intent surgery, often after preoperative (neoadjuvant) radiotherapy (RT), to increase rates of tumor down-staging, clinical and pathologic response, as well as improving surgical resection quality. Read More

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http://dx.doi.org/10.1002/cncr.32150DOI Listing

Association of PDGFRB Mutations With Pediatric Myofibroma and Myofibromatosis.

JAMA Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

Importance: Myofibroma is the most frequent fibrous tumor in children. Multicentric myofibroma (referred to as infantile myofibromatosis) is a life-threatening disease.

Objective: To determine the frequency, spectrum, and clinical implications of mutations in the PDGFRB receptor tyrosine kinase found in sporadic myofibroma and myofibromatosis. Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.0114DOI Listing

Lymphoblastic leukemia following myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms.

Leuk Lymphoma 2019 Apr 24:1-9. Epub 2019 Apr 24.

a Department of Hematopathology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Lymphoblastic leukemia (ALL) following myelodysplastic syndrome (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN) is very rare. We report five cases: four had ALL diagnosed after MDS or MDS/MPN and one had ALL and MDS diagnosed simultaneously. At the onset of ALL, all patients showed co-existing MDS or MDS/MPN. Read More

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http://dx.doi.org/10.1080/10428194.2019.1605509DOI Listing

Giant Primary Retroperitoneal Serous Cystadenoma: A Rare Entity Mimicking Multiple Neoplastic and Nonneoplastic Processes.

Arch Pathol Lab Med 2019 Apr 24. Epub 2019 Apr 24.

From the Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania (Dr Chen); the Department of Pathology, Moffitt Cancer Center, Tampa, Florida (Dr Jiang); and the Department of Oncologic Sciences, University of South Florida College of Medicine, Tampa (Dr Jiang).

Serous cystadenoma, often known as ovarian serous cystadenoma, is one of the common benign ovarian neoplasms. On the other hand, primary retroperitoneal serous cystadenoma is an extremely rare benign entity whose pathogenesis has not been well understood. Clinical presentation and symptomatology vary greatly and are highly dependent on the size and location of the lesion. Read More

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http://dx.doi.org/10.5858/arpa.2018-0245-RSDOI Listing

Dose-painted volumetric modulated arc therapy of high-grade glioma using 3,4-dihydroxy-6-[F]fluoro-l-phenylalanine positron emission tomography.

Br J Radiol 2019 Apr 24:20180901. Epub 2019 Apr 24.

3 Department of Radiation Oncology, BC Cancer - Vancouver , Vancouver , British Columbia, Canada.

Objectives: To determine whether dose painting with volumetric modulated arc therapy (VMAT) for high-grade gliomas using 3,4-dihydroxy-6-[F]fluoro- l -phenylalanine (F-FDOPA) positron emission tomography (PET) could achieve dose-escalated coverage of biological target volumes (BTVs) without increasing the dose to cranial organs at risk.

Methods: Ten patients with high-grade gliomas underwent CT, MRI, and F-FDOPA PET/CT images for postoperative radiation therapy planning. Two VMAT plans were retrospectively generated for each patient: a conventional plan with 60 Gy in 30 fractions to the planning target volume (PTV) delineated on MRI and a dose-escalated plan with a maximum dose of 80 Gy in 30 fractions to BTVs. Read More

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http://dx.doi.org/10.1259/bjr.20180901DOI Listing

First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.

ACS Chem Neurosci 2019 Apr 24. Epub 2019 Apr 24.

The tropomyosin receptor kinase TrkA/B/C family is responsible for human neuronal growth, survival and differentiation from early nervous system development stages onward. Downregulation of TrkA/B/C receptors characterizes numerous neurological disorders including Alzheimer disease (AD). Abnormally expressed Trk receptors or chimeric Trk fusion proteins are also well-characterized oncogenic drivers in a variety of neurogenic and non-neurogenic human neoplasms and are currently the focus of intensive clinical research. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00144DOI Listing

A novel auto-positioning method in Iodine-125 seed brachytherapy driven by preoperative planning.

J Appl Clin Med Phys 2019 Apr 24. Epub 2019 Apr 24.

Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Iodine-125 seed brachytherapy has great potential in the treatment of malignant tumors. However, the success of this treatment is highly dependent on the ability to accurately position the coplanar template. The aim of this study was to develop an auto-positioning system for the template with a design focus on efficiency and accuracy. Read More

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http://dx.doi.org/10.1002/acm2.12591DOI Listing

Dual-phase CT angiography for presurgical planning in patients with vessel-depleted neck.

Head Neck 2019 Apr 24. Epub 2019 Apr 24.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

Background: Microvascular reconstruction in vessel-depleted necks is challenging due to limited availability of recipient vessels. We examine the utility of dual-phase CT angiography (CTA), which delineates both arteries and veins, for preoperative planning in such difficult cases.

Methods: Retrospective chart review of a single surgeon from July 2013 to July 2017 in a tertiary referral center was performed. Read More

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http://dx.doi.org/10.1002/hed.25775DOI Listing

Cytological diagnosis of Langerhans Cell histiocytosis: a series of 47 cases.

Cytopathology 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology, All India Institute of medical sciences (AIIMS), New Delhi, India.

Langerhans cell histiocytosis (LCH) is a rare disease affecting predominantly children and young adults but can be found in any age group. Diagnosis of LCH is often difficult and can be delayed because of its rarity. The present study highlights the cytomorphological features in a large cohort of cases. Read More

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http://dx.doi.org/10.1111/cyt.12709DOI Listing

Analytical validation of a standardized scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicenter collaboration.

Histopathology 2019 Apr 24. Epub 2019 Apr 24.

The Institute of Cancer Research, London, United Kingdom.

Aims: The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of inter-laboratory variability has hampered its clinical utility. The International Ki67 in Breast Cancer Working Group has undertaken a systematic program to determine whether Ki67 measurement can be analytically validated and standardized across laboratories. This study addresses whether acceptable scoring reproducibility can be achieved on excision whole sections. Read More

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http://dx.doi.org/10.1111/his.13880DOI Listing

Hydrogen sulfide abrogates heart valve calcification: Implications for calcific aortic valve disease.

Br J Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.

Background And Purpose: Calcification of heart valves is a frequent pathological finding in CKD patients and in elderly. Hydrogen sulfide (H S) has been suggested to possess various anti-calcific actions. We aimed to investigate H S as a potential therapeutic in valvular calcification and to identify its targets in the pathogenesis. Read More

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http://dx.doi.org/10.1111/bph.14691DOI Listing

[Use of steroids in neuro-oncology].

Rev Neurol 2019 May;68(9):389-397

Hospital Universitario Quiron Salud Madrid, Pozuelo de Alarcon, Espana.

Corticosteroids are widely used in routine clinical practice in neuro-oncology. However, despite their widespread use, there is no established consensus on their indications, dosages and dosage schedule. This article reviews the mechanism of action of corticosteroids, their indications for use, side effects and the appropriate management, dosage and duration of therapy, as well as the role of new treatments currently being use to treat cerebral oedema. Read More

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http://dx.doi.org/10.33588/rn.6809.2019083DOI Listing

Nursing interventions in palliative care in Pediatric Oncology: an integrative review.

Rev Bras Enferm 2019 Mar-Apr;72(2):531-540. Epub 2019 Apr 18.

Universidade Federal Fluminense, Faculdade de Enfermagem. Niterói-RJ, Brasil.

Objective: to identify, in scientific productions, nursing interventions in palliative care in children and adolescents with cancer.

Method: integrative review of the literature through the databases: CINAHL, MEDLINE, IBECS, LILACS and SCIELO, carried out in October and November 2017.

Results: we analyzed 18 articles that met the inclusion criteria. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0121DOI Listing

Operation of a hospital palliative care service: a fourth-generation evaluation.

Rev Bras Enferm 2019 Mar-Apr;72(2):383-390. Epub 2019 Apr 18.

Universidade Estadual de Maringá. Maringá-PR, Brasil.

Objective: Qualitatively evaluate the operation of a palliative care service in oncology.

Methodology: Qualitative study conducted in a service in southern Brazil based on a fourth generation evaluation. Between September 2014 and June 2015, 460 hours of operation were observed, and 45 semi-structured interviews and five negotiation meetings were conducted; data were analyzed using the constant comparative method. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0034-7167-2017-0848DOI Listing
April 2019
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PD-L1 Expression in Men with Penile Cancer and its Association with Clinical Outcomes.

Eur Urol Oncol 2019 Mar 23;2(2):214-221. Epub 2018 Aug 23.

Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: It has been hypothesized that PD-L1 expression in tumor cells and tumor-infiltrating immune (TII) cells may contribute to tumor progression by inhibiting antitumor immunity.

Objective: To investigate the association between PD-L1 expression in tumor cells and TII cells and clinical outcomes in penile cancer.

Design, Setting, And Participants: A cohort of 222 men treated for penile squamous cell carcinoma (SqCC) at Örebro University Hospital between 1984 and 2008 with long-term follow-up (median 34 mo) was evaluated for PD-L1 expression in tumor cells and TII cells via immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.euo.2018.07.010DOI Listing
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