Crit Rev Oncol Hematol 2022 May 14:103708. Epub 2022 May 14.
Grupo Oncoclínicas (GOC), São Paulo, Brazil, Centro Paulista de Oncologia (CPO) - Unidade Faria Lima, Adress: Av. Brigadeiro Faria Lima, 4300, São Paulo - SP, 04538-132.
Breast cancer (BC) is a highly heterogeneous disease, characterized by a variety of subtypes with distinct biological, molecular, and clinical behavior. Standard clinicopathological and tumor biology information (as assessed by gene expression signatures-GES), have provided enhanced prognostic and predictive information in both node-negative(N0) and positive(N+), hormonal receptor positive/human epidermal growth factor 2 negative (HR+/HER2-) early breast cancer (EBC). Herein, we comprehensively review the clinical data of 5 commonly used GES, namely, Oncotype DX(ODX)®; MammaPrint (MP)®; Prosigna®; Breast Cancer Index (BCI)® and Endopredict® - with sections specifically addressing the role of GES in special histologic subtypes, premenopausal women, late recurrence and adjuvant treatment de-escalation. Read More