20,888 results match your criteria Oncologic Emergencies


Risk of bleeding after ultrasound-guided jugular central venous catheter insertion in severely thrombocytopenic oncologic patients.

Am J Surg 2019 Jan 27;217(1):133-137. Epub 2018 Jun 27.

Department of Cardiovascular & Thoracic Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

Introduction: We sought to assess the incidence and risk factors of bleeding after ultrasound-guided internal jugular (USGIJ) catheter insertion in severely thrombocytopenic cancer patients, as safe platelet (PLT) count threshold remains controversial.

Methods: Retrospective study of 52 patients with hematologic malignancies and severe thrombocytopenia who underwent USGIJ catheter insertion between 2014 and 2016. Group A included patients with prophylactic PLT transfusion and Group B without. Read More

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January 2019

A Cadaveric Comparative Study on the Surgical Accuracy of Freehand, Computer Navigation, and Patient-Specific Instruments in Joint-Preserving Bone Tumor Resections.

Sarcoma 2018 13;2018:4065846. Epub 2018 Nov 13.

Department of Orthopedics, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, Netherlands.

Orthopedic oncologic surgery requires preservation of a functioning limb at the essence of achieving safe margins. With most bone sarcomas arising from the metaphyseal region, in close proximity to joints, joint-salvage surgery can be challenging. Intraoperative guidance techniques like computer-assisted surgery (CAS) and patient-specific instrumentation (PSI) could assist in achieving higher surgical accuracy. Read More

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November 2018

Comparison of Quality Oncology Practice Initiative Metrics in Solid Tumor Oncology Clinic With or Without Concomitant Supportive Oncology Consultation.

J Oncol Pract 2018 Dec;14(12):e786-e793

Icahn School of Medicine at Mount Sinai, New York, NY; and The Everett Clinic, Providence Regional Medical Center, Everett, WA.

Purpose:: The Quality Oncology Practice Initiative (QOPI) is a quality measurement and improvement program designed to assess practice performance for various consensus-based and evidence-based measures. In this study, we evaluated differences in QOPI metrics met among patients with advanced solid cancer receiving routine oncologic care alone (routine care) compared with patients receiving integrated oncology and specialty-level palliative care (supportive care).

Methods:: We conducted a retrospective chart review of 100 randomly selected patients treated between June 2013 and June 2015 from our supportive care group and matched these patients to 100 routine care group patients on the basis of tumor type and initial oncology visit date. Read More

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December 2018

A single institutional review of pediatric Bacillus spp. bloodstream infections demonstrates increased incidence among children with cancer.

Pediatr Blood Cancer 2018 Dec 11:e27568. Epub 2018 Dec 11.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.

Background: Bacillus species are known to cause severe infection in immunocompromised hosts. The incidence of Bacillus bloodstream infections and characteristics of infection among children with cancer or indication for hematopoietic cell transplant (HCT) is unknown.

Methods: We performed a retrospective medical record review of all cases of Bacillus bacteremia between January 1, 2005, and December 31, 2014, at Boston Children's Hospital. Read More

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December 2018

Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy.

Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread.

Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Read More

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December 2018
2 Reads

Superior detection of metastatic cystic lymphadenopathy in patients with papillary thyroid cancer by utilization of thyroglobulin washout.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More

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December 2018

Oncologic outcomes in patients with 1-cm to 4-cm differentiated thyroid carcinoma according to extent of thyroidectomy.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Recent guidelines advocate unilateral thyroidectomy for low-risk 1-cm to 4-cm differentiated thyroid cancer (DTC). This study was designed to examine the association between the extent of thyroidectomy and oncologic outcomes in patients with 1-cm to 4-cm DTC.

Materials And Methods: From April 1978 to December 2011, 16 057 patients with DTC underwent thyroidectomy at Yonsei University Hospital. Read More

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December 2018

Overall and Estrogen Receptor-Positive Breast Cancer Incidences Are Decreased Following Bariatric Surgery.

Obes Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.

Introduction: Bariatric surgery treats morbid obesity resulting in long-lasting weight loss. Elevated body mass index (BMI) increases breast cancer risk. We hypothesized that patients undergoing bariatric surgery would have decreased overall and estrogen receptor (ER)-positive breast cancer incidences compared to a propensity-matched non-surgical cohort. Read More

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December 2018

Elastography in prostate gland imaging and prostate cancer detection.

Med Ultrason 2018 Dec;20(4):515-523

Chair of Urology, Department of General and Oncologic Urology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland. Department of General and Oncologic Urology, Nicolaus Copernicus Hospital, Toruń, Poland.

Transrectal prostate biopsies under ultrasonography guidance remain the gold standard for the detection of prostate cancer (PCa). Transrectal ultrasonography (TRUS), however, has a limited sensitivity in PCa detection. Prostate elastography (TRES) increases the sensitivity of a TRUS examination. Read More

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December 2018

Endothelial Function in Children with Acute Lymphoblastic Leukemia (ALL) May Reflect the Clinical Outcome.

Biomed Res Int 2018 11;2018:7918091. Epub 2018 Nov 11.

Division of Angiology, Faculty of Health Science, Wroclaw Medical University, 5 Bartla St., Wroclaw, 51-618, Poland.

Endothelial dysfunction is a common feature of early complications of hemato-oncologic therapy. The aim of our study was to assess the profile of endothelial function at diagnosis time, then during initial treatment phase of acute lymphoblastic leukemia (ALL), and to verify the presence of its correlation with early clinical outcome (ECO). 28 ALL children and 18 healthy age-matched control ones were recruited. Read More

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November 2018

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies.

Front Oncol 2018 26;8:550. Epub 2018 Nov 26.

Italian Institute for Genomic Medicine, Turin, Italy.

The systematic application of next-generation sequencing to large cohorts of oncologic samples has opened a Pandora's box full of known and novel genetic lesions implicated in different steps of cancer development and progression. Narrowing down to B cell malignancies, many previously unrecognized genes emerged as recurrently mutated. The challenge now is to determine how the mutation in a given gene affects the biology of the disease, paving the way to functional genomics studies. Read More

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November 2018

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress and .

Oxid Med Cell Longev 2018 11;2018:6510159. Epub 2018 Nov 11.

Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.

Photobiomodulation (PBM) is emerging as an effective strategy for the management of multiple inflammatory conditions, including oral mucositis (OM) in cancer patients who receive chemotherapy or radiotherapy. Still, the poor understanding of the mechanisms by which the light interacts with biological tissues and the heterogeneity of light sources and protocols employed worldwide significantly limits its applicability. Reactive oxygen species (ROS) are massively generated during the early phases of OM and play a major role in the pathogenesis of inflammation in general. Read More

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November 2018
1 Read

LONG-NONCODING RNAs in gastroesophageal cancers.

Noncoding RNA Res 2018 Dec 1;3(4):195-212. Epub 2018 Nov 1.

Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, PD, Italy.

Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying 'targetable' molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. Read More

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December 2018

Task-Based Model Observer Assessment of A Partial Model-Based Iterative Reconstruction Algorithm in Thoracic Oncologic Multidetector CT.

Sci Rep 2018 Dec 7;8(1):17734. Epub 2018 Dec 7.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland.

To investigate the impact of a partial model-based iterative reconstruction (ASiR-V) on image quality in thoracic oncologic multidetector computed tomography (MDCT), using human and mathematical model observers. Twenty cancer patients examined with regular-dose thoracic-abdominal-pelvic MDCT were retrospectively included. Thoracic images reconstructed using a sharp kernel and filtered back-projection (reference) or ASiR-V (0-100%, 20% increments; follow-up) were analysed by three thoracic radiologists. Read More

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December 2018

Gamma knife radiosurgery for local recurrence of glioblastoma.

Neuro Endocrinol Lett 2018 Oct 12;39(4):281-287. Epub 2018 Oct 12.

Department of Medical Physics, Na Homolce Hospital, Prague, Czech Republic.

Objective: Local recurrence of glioblastoma is observed in most patients after standard oncologic treatment (surgery, chemotherapy and radiotherapy). Stereotactic radiosurgery with the Leksell Gamma Knife (SRS with LGK) was used to treat recurrent tumors in selected cases, and retrospective analysis of treatment outcome was performed.

Methods: Altogether 126 patients were treated for glioblastoma at our center from 1992-2014. Read More

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October 2018

Is the Medial Sural Artery Perforator Flap A New Workhorse Flap? A Systematic Review and Meta-Analysis.

Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.

Background: The medial sural artery perforator (MSAP) flap offers thin, pliable tissue with a relatively long pedicle and low donor site morbidity. This study explores the characteristics and uses of the MSAP flap as well as postoperative outcomes and complications.

Methods: A systematic literature review was performed using PubMed, Embase, and Cochrane CENTRAL to identify all cases of MSAP flap reconstruction. Read More

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November 2018

Postural control skills, proprioception, and risk of fall in long-term survivor patients treated with knee rotationplasty.

Int J Rehabil Res 2018 Dec 10. Epub 2018 Dec 10.

3rd Orthopaedic and Traumatologic Clinic prevalently Oncologic, IRCCS - Istituto Ortopedico Rizzoli, Bologna, Italy.

Knee A1 rotationplasty is a particular type of limb salvage surgery alternative to hip disarticulation and high transfemoral amputation for skeletally immature children with bone cancers in the distal femur. Notwithstanding optimal functional outcomes, long-term survivor patients often report frequent falls, and a sense of instability during gait, particularly on uneven terrain. This study aimed to assess the postural control, the proprioception, and the risk of fall in these patients, which have not been explored before. Read More

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December 2018

Oncologic and Surgical Outcomes of Robotic Versus Open Radical Hysterectomy for Cervical Cancer.

J Obstet Gynaecol Can 2018 Dec 7. Epub 2018 Dec 7.

Division of Gynecologic Oncology, Segal Cancer Centre, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, QC. Electronic address:

Objective: In view of the recent controversy concerning the use of minimally invasive radical hysterectomy as primary treatment for early stage cervical cancer, this study compared the survival and perioperative outcomes in a cohort of patients who underwent radical hysterectomy either by laparotomy or by robotics.

Methods: This retrospective study compared all consecutive patients with early stage cervical cancer since the beginning of the Division of Gynecologic Oncology at the Jewish General Hospital in 2003, who underwent robotic radical hysterectomy (n = 74) with a cohort of all consecutive patients from the immediate past who underwent open radical hysterectomy (n = 24) for early stage cervical cancer. All patients were treated at the Jewish General Hospital in Montréal (Canadian Task Force Classification II-2). Read More

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December 2018
1 Read

Electrochemotherapy - Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration.

Eur J Surg Oncol 2018 Dec 1. Epub 2018 Dec 1.

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

The treatment of tumors with electrochemotherapy (ECT) has surged over the past decade. Thanks to the transient cell membrane permeabilization induced by the short electric pulses used by ECT, cancer cells are exposed to otherwise poorly permeant chemotherapy agents, with consequent increased cytotoxicity. The codification of the procedure in 2006 led to a broad diffusion of the procedure, mainly in Europe, and since then, the progressive clinical experience, together with the emerging technologies, have extended the range of its application. Read More

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December 2018

The impact of statins in combination with androgen deprivation therapyin patients with advanced prostate cancer: A large observational study.

Urol Oncol 2018 Dec 7. Epub 2018 Dec 7.

The University of Wisconsin-Madison, Department of Urology, Madison, WI; William S. Middleton Memorial Veterans Hospital, Department of Surgery, Section of Urology, Madison, WI. Electronic address:

Background: Statins are thought to possess antineoplastic properties related to their effect on cell proliferation and steroidogenesis. Progression to castrate resistant prostate cancer (CaP) includes de-regulation of androgen synthesis suggesting a role for statins in this setting. Our goal was to assess the role of statin use on oncologic outcomes in patients with advanced CaP being treated with androgen deprivation therapy (ADT). Read More

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December 2018

Clinical spectrum of PTEN mutation in pediatric patients. A bicenter experience.

Eur J Med Genet 2018 Dec 4. Epub 2018 Dec 4.

Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Objective Of The Study: To give a full overview of the clinical presentation of PTEN mutations in pediatric patients and to propose a pediatric follow-up protocol.

Methods: Recruitment of 16 PTEN mutated children (age 6 months-11 years) from two pediatric centers in Milan (Italy) between 2006 and 2017. All the patients underwent clinical and neurologic evaluations, cognitive and behavioral tests, and brain MRI; they are currently following an oncologic follow-up. Read More

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December 2018
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Does Surgical Treatment of Atypical Endometrial Hyperplasia Require Referral to a Gynecologic Oncologist?

Am J Obstet Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Wake Forest University School of Medicine; Winston-Salem, NC.

Patients with atypical endometrial hyperplasia (AEH) in the United States are commonly referred to a gynecologic oncologist given a moderate risk of concurrent carcinoma. However, selective referral of patients to non-oncologic gynecologic surgeons for surgical treatment of AEH may offer increased access to care without compromising clinical outcomes. Non-oncologic surgeons who consider providing surgical treatment for AEH must be able to offer minimally invasive surgery when appropriate and have sufficient surgical volume to deliver optimal clinical outcomes. Read More

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December 2018

An Integrated Review of Cannabis and Cannabinoids in Adult Oncologic Pain Management.

Pain Manag Nurs 2018 Dec 6. Epub 2018 Dec 6.

University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania.

Objective: The objective of this paper is to review the available literature regarding the use of cannabis and cannabinoids in adult oncologic pain management.

Design And Data Sources: A integrative review was conducted on March 1, 2018 using PubMed, MEDLINE, CINAHL, Embase, and Scopus. A snowball method was used to extract studies included in systematic reviews that were not included in the primary literature search. Read More

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December 2018
1 Read

Evolution of robotic systems for transoral head and neck surgery.

Oral Oncol 2018 Dec 25;87:82-88. Epub 2018 Oct 25.

Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Oropharyngeal tumor is traditionally resected from an open approach, often necessitating the need of a midline mandibulotomy in order to remove tumor safely with oncologic margins. The limitations imposed by a transoral route include poor visualization of the inferior extent of the oropharynx, rigid instrumentation, and inability to resect tumor that extends caudally into the supraglottis. While visualization with angled endoscopes, coupled with flexible laser development and microscopic magnification may overcome some of these limitations, this technique suffers from linear trajectory of the instruments which hampers expedient surgical resection in a 3-dimensional fashion. Read More

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December 2018
1 Read

Treatment of early-stage laryngeal cancer: A comparison of treatment options.

Oral Oncol 2018 Dec 16;87:8-16. Epub 2018 Oct 16.

Stanford University School of Medicine, Department of Otolaryngology Head and Neck Surgery, USA.

Over the course of the last several decades, the treatment options for early laryngeal cancers (T1 and T2) have evolved; however, simultaneously the mortality rate has increased. As larynx preservation approaches have become the standard of care, the selection of the proper treatment modality has become paramount. Radiation therapy or transoral laser microsurgery are the most common options for treatment of these early lesions. Read More

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December 2018

Validation of the immunohistochemical expression of programmed death ligand 1 (PD-L1) on cytological smears in advanced non small cell lung cancer.

Lung Cancer 2018 Dec 17;126:9-14. Epub 2018 Oct 17.

Department of Thoracic Endoscopy, S.Orsola-Malpighi Teaching Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

Introduction The assessment of PD-L1 expression by immunohistochemistry is mandatory for the administration as first-line therapy of the anti PD-1 check-point inhibitor Pembrolizumab in patients with advanced non-small-cell lung cancer (NSCLC). Currently, only formalin-fixed paraffin-embedded samples are acceptable for PD-L1 immunostaining with the anti-PD-L1 antibodies 22-C3 and SP263. We investigated retrospectively the accuracy of the anti PD-L1 antibodies 22-C3, 28-28, SP263 in 50 paired histological samples and cytological smears of NSCLC patients. Read More

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December 2018

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2018 Dec 11:3489418806914. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

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December 2018
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[Analysis of three methods of nutritional screening in oncologic patients].

Nutr Hosp 2018 Dec 3;35(6):1324-1330. Epub 2018 Dec 3.

Hospital Punta Europa (Algeciras).

Background: malnutrition is one of the complications that appears most frequently in oncological patients and causes serious consequences such as loss of lean mass.

Objective: to know which nutritional screening method is most useful in predicting the loss of lean mass in cancer patients.

Methods: a descriptive study was carried out evaluating three methods of nutritional screening, Malnutrition Screening Tool (MST), Malnutrition Universal Screening (MUST) and Nutritional Risk Screening (NRS-2002), in oncological patients undergoing radiotherapy treatment. Read More

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December 2018

Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

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December 2018

Laparoscopic Multiple Parenchyma-sparing Concomitant Liver Resections for Colorectal Liver Metastases.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Intervention Centre.

Background: Parenchyma-sparing concept in liver surgery has received a new incitement with the introduction of laparoscopic techniques. Multiple concomitant liver resections are a major component in the parenchyma-sparing concept.

Materials And Methods: In total, 689 patients underwent laparoscopic liver resection for colorectal liver metastases from August 1998 to 2017, and 171 patients were eligible for this study. Read More

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December 2018

Promising Long-Term Outcomes After Pelvic Exenteration.

Ann Surg Oncol 2018 Dec 5. Epub 2018 Dec 5.

Chirurgische Klinik I, Lukaskrankenhaus Neuss, Neuss, Germany.

Background: Pelvic exenteration (PE) is a complex and challenging surgical procedure. The reported results of this procedure for primary and recurrent disease are limited and conflicting.

Methods: This study analyzed patient outcomes after all PEs performed in the authors' department between October 2001 and December 2016. Read More

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December 2018

Factors influencing intraoperative conversion from planned orthotopic to non-orthotopic urinary diversion during radical cystectomy.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

USC Institute of Urology, Keck Medicine of USC, University of Southern California, Los Angeles, CA, USA.

Objectives: To determine and investigate the intraoperative factors that contribute to a change in plan from continent orthotopic neobladder to ileal conduit or continent cutaneous diversion at the time of radical cystectomy.

Subjects And Methods: A retrospective review of our prospectively maintained bladder cancer database was performed. Of the 711 patients who underwent radical cystectomy from 2012 to 2016, 387 (54. Read More

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December 2018
3 Reads

Microsurgical reconstruction with vascularized fibula and massive bone allograft for bone tumors.

Eur J Orthop Surg Traumatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Rizzoli, via Pupilli n1, 40136, Bologna, Italy.

Introduction: Combining massive bone allograft and vascularized fibula in intercalary reconstruction following resection of bone tumors represents a complex reconstructive procedure that requires specialists in microvascular surgery as well as orthopedic surgery. The purpose of our study was to examine the outcomes using this surgical technique in patients with bone tumors in terms of oncologic results, complications related to surgery, Musculoskeletal Tumor Society (MSTS) scores and duration of surgery.

Materials And Methods: We analyzed 81 patients with femoral or tibial sarcomas who underwent intercalary resection and microsurgical reconstruction with massive bone allograft and vascularized fibula. Read More

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December 2018

Impact of the anterior commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy: a retrospective study.

Cancer Manag Res 2018 8;10:5553-5558. Epub 2018 Nov 8.

Otolaryngology, Department of Health Sciences, University of Catanzaro, Catanzaro, Italy,

Background: Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the anterior commissure remains controversial. The studies about the role of anterior commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. Read More

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November 2018

Involving "authentic" cancer patients, their caregivers, and multidisciplinary professionals in a quality improvement trajectory in a hospital cancer pathway: a study protocol.

J Multidiscip Healthc 2018 9;11:661-671. Epub 2018 Nov 9.

Department of Internal Medicine, Zuyderland Medical Centre, Sittard, The Netherlands,

Introduction: The implementation of oncology care pathways that standardize organizational procedures has improved cancer care in recent years. However, the involvement of "authentic" patients and caregivers in quality improvement of these predetermined pathways is in its infancy, especially the scholarly reflection on this process. We, therefore, aim to explore the multidisciplinary challenges both in practice, when cancer patients, their caregivers, and a multidisciplinary team of professionals work together on quality improvement, as well as in our research team, in which a social scientist, health care professionals, health care researchers, and experience experts design a research project together. Read More

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November 2018

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways.

J Exp Clin Cancer Res 2018 Dec 5;37(1):304. Epub 2018 Dec 5.

Department of Pathology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, China.

Background: Inosine 5'-monophosphate dehydrogenase type II (IMPDH2) was originally identified as an oncogene in several human cancers. However, the clinical significance and biological role of IMPDH2 remain poorly understood in colorectal cancer (CRC).

Methods: Quantitative real-time polymerase chain reaction (qPCR), western blotting analysis, the Cancer Genome Atlas (TCGA) data mining and immunohistochemistry were employed to examine IMPDH2 expression in CRC cell lines and tissues. Read More

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December 2018

Oncologic management of sinonasal undifferentiated carcinoma.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 16. Epub 2018 Nov 16.

Department of Otolaryngology-Head and Neck Surgery.

Purpose Of Review: This article reviews the latest treatment paradigms in sinonasal undifferentiated carcinoma (SNUC).

Recent Findings: The aggressive biology and associated advanced presentation of SNUC make successful treatment a challenge shared across medical specialties. Still, studies reporting outcomes in SNUC indicate that an aggressive treatment strategy consisting of surgery, radiation and chemotherapy offers the best chance of prolonged survival. Read More

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November 2018
2 Reads

Negative interactions among nurses. An explorative study on lateral violence and bullying in nursing work settings.

J Nurs Manag 2018 Dec 1. Epub 2018 Dec 1.

Department of Health Sciences, University of Florence, Florence, Italy.

Background: Lateral violence and bullying affect nurses' professional and health status. Worldwide prevalence ranges from 1 to 87%.

Aim: To investigate prevalence and risk factors of lateral violence and bullying among Italian nurse peers in different work settings, inside and outside hospitals. Read More

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December 2018

[Role of oncologic radiotherapy in multidisciplinary team treatment of malignant acute abdomen].

Authors:
Yuhong Dai Hong Qiu

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1212-1217

Tongji Hospital Cancer Center, Tongji Medical College Affiliated, Huazhong University of Science and Technology,Wuhan 430030, China. Email:

Malignant acute abdomen is a emergency with abrupt onset, rapid progress and often a complex etiology, presenting difficulties for treatment and high mortality. Therefore, multidisciplinary team (MDT) treatment modality is required. Compared with single-discipline diagnosis and treatment modality, diagnosis made from MDT discussion is more accurate, where specialists can improve efficiency and quality of the treatment through better communication. Read More

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November 2018
1 Read

[Role of surgical oncologists in multidisciplinary team treatment of malignant acute abdomen].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1206-1211

Department of Oncology, The Fourth Affiliated Hospital of Harbin Medical University, Haerbin 154000, China.Email:

Malignant acute abdomen is an acute abdominal disease caused by abdominal and extra-abdominal malignant tumors or secondary to various treatments for tumors, and belongs to the category of oncologic emergencies. Malignant acute abdomen includes perforation, bowel obstruction, infection and bleeding, etc. Most of the malignant acute abdomen is urgent and critical. Read More

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November 2018

Incisions and reconstruction approaches for large sarcomas.

Transl Gastroenterol Hepatol 2018 31;3:86. Epub 2018 Oct 31.

Division of Plastic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Large intraabdominal, retroperitoneal, and abdominal wall sarcomas provide unique challenges in treatment due to their variable histology, potential considerable size at the time of diagnosis, and the ability to invade into critical structures. Historically, some of these tumors were considered inoperable if surgical access was limited or the consequential defect was unable to be closed primarily as reconstructive options were limited. Over time, there has been a greater understanding of the abdominal wall anatomy and mechanics, which has resulted in the development of new techniques to allow for sound oncologic resections and viable, durable options for abdominal wall reconstruction. Read More

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October 2018
1 Read

Clinical fate of T0N1 esophageal cancer: results from the National Cancer Database.

J Gastrointest Oncol 2018 Oct;9(5):880-886

Sarasota Memorial Hospital, Florida State University College of Medicine, Sarasota, FL, USA.

The long-term survival for patients with locally advanced esophageal cancer (EC) remains poor despite improvements in multi-modality care. Neoadjuvant chemoradiation (NCR) followed by surgical resection remains pivotal in the management of patients with EC. However, the outcome of patients whose primary tumor exhibits a complete response with residual regional nodal disease (T0N1) remains unclear as well as the role for adjuvant therapy. Read More

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October 2018
2 Reads

Morbidity and mortality of synchronous hepatectomy with cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).

J Gastrointest Oncol 2018 Oct;9(5):828-832

Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Liver resection in conjunction with partial colectomy for colon cancer is considered acceptable treatment for isolated metastasis to the liver. This method is unstudied in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for carcinomatosis due to colon cancer and high grade appendiceal cancer.

Methods: A retrospective chart review included patients from 2005 to 2016 undergoing CRS/HIPEC. Read More

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October 2018
1 Read

Quantitative accuracy of positron emission tomography/magnetic resonance and positron emission tomography/computed tomography for cervical cancer.

World J Nucl Med 2018 Oct-Dec;17(4):213-218

Biomedical Research Imaging Center, Chapel Hill, NC, USA.

With the spread of positron emission tomography/magnetic resonance (PET/MR), the question of comparability of studies becomes important. We aim to determine whether PET/MR and PET/computed tomography (PET/CT) are comparable for the case of cervical cancer. Fifteen cervical cancer patients identified by either a radiation oncologist or an oncologic surgeon had both PET/MR and PET/CT performed for initial staging within 3 weeks. Read More

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December 2018
1 Read

Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?

Neurology 2018 Nov 30. Epub 2018 Nov 30.

From the Departments of Neurosurgery (A.R., M.Z., E.D., G.Z.-B., J.P.), Neuroradiology (M.E., S. Porelli, C.O), and Neuropathology (A.T.-E., P.V.), Sainte-Anne Hospital; Paris Descartes University (A.R., M.E., S. Porelli, A.T.-E., M.Z., E.D., G.Z.-B., S. Puget, P.V., C.O., J.P.), Sorbonne Paris Cité; Inserm (A.R., M.E., M.Z., E.D., P.V., C.O., J.P.), U894, IMA-Brain, Centre Psychiatrie et Neurosciences; Departments of Neuro-oncology (M.S.) and Neurosurgery (L.C.), Pitié-Salpêtrière Hospital; and Department of Pediatric Neurosurgery (S. Puget), Necker Hospital, Paris, France.

Objective: To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma.

Methods: We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié-Salpêtrière Hospital (external validation set). We included 219 patients with diffuse glioma (experimental set), 252 patients with brain metastasis (control set), and 200 patients with diffuse glioma (validation set). Read More

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November 2018
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Time trend prevalence of artificial nutrition counselling in a university hospital.

Nutrition 2018 Aug 24;58:181-186. Epub 2018 Aug 24.

Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.

Objectives: The negative effects of malnutrition on the prognosis of hospitalized patients are well documented; however, less known is the awareness and knowledge of health care professionals about this complication. The aim of this study was to evaluate the trend of the requests for nutritional consultation in years and the prescription of artificial nutrition (AN), for adult patients at a university hospital in southern Italy in the years 2004, 2008, 2012, and 2016 to assess the progress of medical teams concerning awareness of hospital malnutrition.

Methods: This was a retrospective study that evaluated the time trend of nutritional consultation requests and related prescription of AN, for adult patients at a university hospital in southern Italy in the years 2004, 2008, 2012, and 2016. Read More

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August 2018
2.926 Impact Factor

Comparison of transperitoneal laparoscopic versus open adrenalectomy for large pheochromocytoma: A retrospective propensity score-matched cohort study.

Int J Surg 2018 Nov 29;61:26-32. Epub 2018 Nov 29.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:

Background: Surgical resection is the main treatment strategy for pheochromocytoma. Whether laparoscopic techniques are feasible for large pheochromocytoma treatments is controversial. The aim of this study was to evaluate the feasibility and safety of transperitoneal laparoscopic adrenalectomy (LA) compared with open adrenalectomy (OA). Read More

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November 2018
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Compartimental harvesting of dual lymph node flap from the right supraclavicular area for the treatment of lower extremity lymphedema: A case series.

J Plast Reconstr Aesthet Surg 2018 Nov 19. Epub 2018 Nov 19.

Department of Plastic and Reconstructive Surgery, Centre for Surgical Treatment of Lymphedema, Università Cattolica del "Sacro Cuore" - Fondazione Policlinico "A. Gemelli" IRCSS - Largo A. Gemelli 8, 00169 Rome, Italy.

Background: We report our clinical experience of a supraclavicular lymph node flap (LNF) using a novel method of harvesting based on the compartimental lymphatic and vascular anatomy of the right posterior neck triangle, which allows to harvest two independent LNFs from the same donor site.

Patients And Methods: We report a case series of 10 consecutive patients affected by cancer-related lower extremity lymphedema, who underwent compartimental dual LNF transfer from the right supraclavicular area to the affected lower limb, from August 2015 to March 2017. The superficial compartment flap (venous flap along the external jugular vein) was anastomosed in a flow-through fashion along the course of the great saphenous vein in the knee region, whereas the deep compartment flap (transverse cervical artery/vein flap) was anastomosed in an end-to-end fashion to the medial sural artery and comitantes vein. Read More

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November 2018
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Outpatient desensitization of patients with moderate (high-risk) to severe platinum hypersensitivity reactions.

Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.

Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, The Ohio State University College of Medicine, Columbus, OH 43220, USA. Electronic address:

Objectives: Platinum hypersensitivity reactions (HSR) affect approximately 5% of the general oncologic population. Here we report the efficacy and safety of outpatient platinum desensitization protocol (PD) in gynecologic oncology patients with moderate (high-risk) to severe platinum HSR.

Methods: This is a retrospective report of patients with gynecologic malignancies undergoing an outpatient PD for moderate (high-risk) to severe platinum HSR from 2011 to 2017. Read More

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November 2018
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Minimally Invasive Surgical Site Infection in Procedure-Targeted ACS NSQIP Pancreaticoduodenectomies.

J Surg Res 2019 Jan 29;233:183-191. Epub 2018 Aug 29.

Division of Advanced Oncologic and Gastrointestinal Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina. Electronic address:

Background: Pancreaticoduodenectomy (PD) incurs a surgical site infection rate of up to 18%. Published rates after minimally invasive PD are comparable or superior to open, but data are limited to high-volume, single-institution series. This study aimed to determine national outcomes. Read More

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January 2019
3 Reads