3,555 results match your criteria OncoTargets and Therapy [Journal]


Tumor necrosis factor α knockout impaired tumorigenesis in chronic myeloid leukemia cells partly by metabolism modification and miRNA regulation.

Onco Targets Ther 2019 29;12:2355-2364. Epub 2019 Mar 29.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,

Purpose: Half of the chronic myeloid leukemia (CML) patients with sustained deep molecular response suffer from relapse after discontinuation mainly because tyrosine kinase inhibitors (TKIs) cannot eradicate leukemia stem cells (LSCs). In addition, tumor necrosis factor α (TNF-α) is highly detected in CML patients. Our aim was to explore whether TNF-α is a potential target for LSC elimination. Read More

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http://dx.doi.org/10.2147/OTT.S197535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446984PMC

Molecular subtype classification of papillary renal cell cancer using miRNA expression.

Onco Targets Ther 2019 29;12:2311-2322. Epub 2019 Mar 29.

Department of Oncology, The People's Hospital of Hanchuan City, Hanchuan 431600, Hubei, People's Republic of China,

Background: Renal papillary cell carcinoma (KIRP) is a relatively rare renal malignancy. Although KIRP subtyping about clinical relevance has been defined, there have been scarce number of studies on the molecular characteristics of KIRP subtypes.

Method: In this study, a independent samples -test was used to identify differentially expressed (DE) miRNAs between tumor and normal samples of KIRP. Read More

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http://dx.doi.org/10.2147/OTT.S193808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446988PMC

SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism.

Onco Targets Ther 2019 28;12:2397-2408. Epub 2019 Mar 28.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China,

Background: SIRT4, a protein localized in the mitochondria, is one of the least characteristic members of the sirtuin family. It is known that SIRT4 has deacetylase activity and plays a role in energy metabolism, but little is known about its possible role in carcinogenesis. Recently, several studies have suggested that SIRT4 may function as either a tumor oncogene or a tumor suppressor gene. Read More

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http://dx.doi.org/10.2147/OTT.S189536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445187PMC

Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma.

Onco Targets Ther 2019 28;12:2383-2396. Epub 2019 Mar 28.

Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China,

Purpose: Glioma is a malignant tumor that originates in the brain and spine and is difficult to be completely removed. Though glioma patients receive active treatment, the survival rate is still poor. Therefore, it is urgent to discover a new medicine to treat glioma patients in order to improve the survival rate. Read More

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http://dx.doi.org/10.2147/OTT.S191158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445239PMC

Overexpression of miR-664 is associated with poor overall survival and accelerates cell proliferation, migration and invasion in hepatocellular carcinoma.

Onco Targets Ther 2019 28;12:2373-2381. Epub 2019 Mar 28.

Department of General Surgery, Qianfoshan Hospital Affiliated to Shandong University, Shandong 250014, China,

Introduction: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. This study aimed to investigate the expression patterns of microRNA-664 (miR-664) in HCC tissues and cells, and assess its clinical significance and functional role in HCC.

Patients And Methods: One hundred and thirty-four paired HCC and non-cancerous tissues were collected from patients who underwent surgery in Qianfoshan Hospital affiliated to Shandong University (Shandong, China) between 2009 and 2012. Read More

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http://dx.doi.org/10.2147/OTT.S188658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445241PMC

Postchemotherapy sarcoma as a somatic-type malignancy derived from the gonadal yolk sac tumor in a patient with 46, XY pure gonadal dysgenesis.

Onco Targets Ther 2019 28;12:2365-2372. Epub 2019 Mar 28.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

46, XY pure gonadal dysgenesis (PGD) is characterized as a female phenotype with strip-like gonads, which has a high tendency to develop into gonadal tumors. Somatic-type malignancies of germ cell tumors (SMs of GCTs) refer to the presence of malignant non-germ cell histologies admixed with GCTs, which are usually chemoresistant and indicate poor prognosis. This case report aimed to analyze the special histological type of GCTs and the importance of salvage surgery in the treatment of refractory GCTs. Read More

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http://dx.doi.org/10.2147/OTT.S192111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445222PMC

1,25-Dihydroxyvitamin D affects gastric cancer progression by repressing BMP3 promoter methylation.

Onco Targets Ther 2019 28;12:2343-2353. Epub 2019 Mar 28.

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211800, People's Republic of China,

Background: Vitamin D has been known to have an anticancer effect, but the mechanisms underlying this is poorly explored. The present study aimed to investigate the antitumor role of vitamin D on gastric cancer and mechanisms.

Methods: The Roche Elecsys platform was applied in retrospective studies to detect the role of 25-hydroxylvitamin D in adenocarcinoma and colony formation assay was conducted to verify the effect of 1, 25-dihydroxyvitamin D on the proliferation of gastric cancer cells. Read More

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http://dx.doi.org/10.2147/OTT.S195642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445188PMC

Comparison of CHOP vs CHOPE for treatment of peripheral T-cell lymphoma: a meta-analysis.

Onco Targets Ther 2019 28;12:2335-2342. Epub 2019 Mar 28.

Department of Orthopedics, TongDe Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China,

Objective: To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL).

Methods: Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible trials comparing CHOP with CHOPE for treatment of PTCL. The following outcomes of PTCL patients were considered: complete response (CR), partial response (PR), overall response rate (ORR), and adverse events (AEs; grade >3). Read More

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https://www.dovepress.com/comparison-of-chop-vs-chope-for-tr
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http://dx.doi.org/10.2147/OTT.S189825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445243PMC
March 2019
6 Reads

MicroRNA-221 promotes papillary thyroid carcinoma cell migration and invasion via targeting RECK and regulating epithelial-mesenchymal transition.

Onco Targets Ther 2019 28;12:2323-2333. Epub 2019 Mar 28.

Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, People's Republic of China,

Aim: The aim of this study was to detect the effects and potential mechanisms of microRNA-221 on a series of biological behaviors of papillary thyroid carcinoma (PTC) cells in vitro and in vivo.

Methods: First, we analyzed the relationship between the expression of miR-221 and several clinicopathological features of PTC patients and then detected the expression of the miR-221 in tumor tissues and cell lines. The effects of miR-221 on proliferation and invasion of PTC cells were verified by cell counting kit-8 (CCK-8) assay, wound healing assay and transwell assay. Read More

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https://www.dovepress.com/microrna-221-promotes-papillary-th
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http://dx.doi.org/10.2147/OTT.S190364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445232PMC
March 2019
1 Read

Development and validation of prognostic nomograms for medullary thyroid cancer.

Onco Targets Ther 2019 27;12:2299-2309. Epub 2019 Mar 27.

Department of General Surgery, West Anhui Health Vocational College, Luan, Anhui 237000, China,

Background: This aim of study was to develop and validate clinical nomograms to predict the survival of patients with medullary thyroid cancer.

Patients And Methods: Patient data were collected from the Surveillance, Epidemiology, and End Results database between 2004 and 2013. All included patients were randomly assigned into the training and validation sets. Read More

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https://www.dovepress.com/development-and-validation-of-prog
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http://dx.doi.org/10.2147/OTT.S196205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441551PMC
March 2019
1 Read

TRIM31 promotes glioma proliferation and invasion through activating NF-κB pathway.

Onco Targets Ther 2019 27;12:2289-2297. Epub 2019 Mar 27.

Department of Rehabilitation, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China,

Background: Glioma is the most lethal primary brain tumor, the survival rate still isn't improved in the past decades. It's essential to study the regulatory mechanism of glioma progression, hoping to find new therapy targets or methods. The family of tripartite motif (TRIM) containing proteins are E3 ubiquitination ligases, which play critical role in various tumor progression. Read More

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http://dx.doi.org/10.2147/OTT.S183625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441556PMC
March 2019
2 Reads

Management of recurrent Ewing sarcoma: challenges and approaches.

Onco Targets Ther 2019 27;12:2279-2288. Epub 2019 Mar 27.

Department of Pediatrics, Division of Hematology/Oncology, Duke University, Durham, NC, USA,

Although many patients with newly diagnosed Ewing sarcoma can become long-term survivors, relapse remains an important clinical problem for which there is no standard approach. Several prognostic factors have been identified, and these may help guide patient counseling and therapy decisions. A variety of chemotherapy regimens have produced responses in patients with recurrent Ewing sarcoma, but no comparative studies have been completed to show superiority of any one particular approach. Read More

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https://www.dovepress.com/management-of-recurrent-ewing-sarc
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http://dx.doi.org/10.2147/OTT.S170585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441548PMC
March 2019
1 Read

Selecting treatment options in refractory metastatic colorectal cancer.

Onco Targets Ther 2019 27;12:2271-2278. Epub 2019 Mar 27.

Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra, Lake Success, NY, USA,

Survival of patients with metastatic colorectal cancer (mCRC) has significantly improved in the last decade. Survival gains are not driven by advances in first-line therapy but by incremental additional effects of subsequent treatment lines. To maximize outcomes, patients should receive all active agents. Read More

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http://dx.doi.org/10.2147/OTT.S194605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441549PMC
March 2019
1 Read

A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo-YAP signaling pathway.

Onco Targets Ther 2019 27;12:2259-2269. Epub 2019 Mar 27.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027, People's Republic of China,

Purpose: Gastric carcinoma is the second most frequently diagnosed cancer and leading cause of cancer death in China. As a new generation of cancer therapeutic drug, CL-6, a curcumin derivative, shows better bioavailability than curcumin, which has shown anticancer effects in gastric cancer (GC). However, whether CL-6 shows similar activities in GC has not been examined. Read More

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http://dx.doi.org/10.2147/OTT.S196914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441554PMC

MDM2 promotes epithelial-mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma.

Onco Targets Ther 2019 27;12:2247-2258. Epub 2019 Mar 27.

Southern Medical University, Guangzhou, China,

Background: Mouse double minute 2 (MDM2) contributes to cancer metastasis and epithelial-mesenchymal transition (EMT). This study aimed to investigate small mothers against decapentaplegic (Smad) signaling in MDM2-mediated EMT in lung adenocarcinoma (LAC).

Materials And Methods: Expression patterns of MDM2 in LAC tissues, adjacent tissues, and cell lines (BEAS-2B, PC9, H1975, and A549) were detected. Read More

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http://dx.doi.org/10.2147/OTT.S185076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441555PMC

TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway.

Onco Targets Ther 2019 27;12:2235-2245. Epub 2019 Mar 27.

Department of Gynaecology, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China,

Objective: The aim of this study was to examine the effect of on proliferation, apoptosis, and migration of endometrial cancer (EC) cells and explore the relationship between TRIB3 and AKT signaling pathway in EC progression.

Methods: Immunohistochemical analysis was performed to measure the expression level of TRIB3 in normal endometrium tissues and EC tissues. Overexpression and shRNA knockdown techniques were applied by transfecting EC cells (ISK and AN3CA), and the effect of TRIB3 on EC cell biological behaviors was evaluated. Read More

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http://dx.doi.org/10.2147/OTT.S189001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441550PMC

Effect of Th9/IL-9 on the growth of gastric cancer in nude mice.

Onco Targets Ther 2019 26;12:2225-2234. Epub 2019 Mar 26.

Department of Gastrointestinal Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, People's Republic of China,

Objective: By neutralizing IL-9 in a nude mouse model, the study aimed to investigate the role of Th9/IL-9 on the growth of gastric cancer in mice.

Materials And Methods: Male BALB/c nude mice were randomly divided into three groups: a normal control group (Control), an SGC-7901 xenografted nude mice model group (Model), and a rIL-9 treatment group (Treat). The weight of the tumors was recorded to calculate the tumor inhibition rate. Read More

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https://www.dovepress.com/effect-of-th9il-9-on-the-growth-of
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http://dx.doi.org/10.2147/OTT.S197816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441462PMC
March 2019
1 Read

The impact of adjuvant radiotherapy on molecular prognostic markers in gliomas.

Onco Targets Ther 2019 26;12:2215-2224. Epub 2019 Mar 26.

Department of Pathology, Laboratory of Clinical Genetics and Molecular Pathology, 10th Military Hospital, Bydgoszcz, Poland.

Purpose: Changes in promoter methylation, and mutation, and 1p/19q co-deletion status in gliomas between first and subsequent resections and their associated clinical factors are poorly described. In this study, we assayed these biomarkers in the clinical setting.

Patients And Methods: We used multiplex ligation-dependent probe amplification to measure promoter methylation, mutation status, and 1p/19q co-deletion in 45 paired tumor samples from patients undergoing resection and subsequent re-resections for gliomas. Read More

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http://dx.doi.org/10.2147/OTT.S200818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441459PMC
March 2019
1 Read

Efficacy of on-demand intrahepatic arterial therapy in combination with sorafenib for advanced hepatocellular carcinoma.

Onco Targets Ther 2019 26;12:2205-2214. Epub 2019 Mar 26.

Department of Gastroenterology, Toyama University Hospital, Toyama, Japan,

Purpose: The purpose of this study was to evaluate the effectiveness and tolerability of "on-demand" combination therapy with sorafenib and hepatic arterial treatments, such as transarterial chemoembolization and hepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma (HCC).

Patients And Methods: Eighty consecutive patients with advanced HCC, 58 administered sorafenib monotherapy and 22 administered on-demand combination therapy, were retrospectively evaluated.

Results: The disease control rate was significantly higher in the combination group than in the monotherapy group (86. Read More

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http://dx.doi.org/10.2147/OTT.S191741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441463PMC
March 2019
1 Read

LINC01296 promotes proliferation, migration, and invasion of HCC cells by targeting miR-122-5P and modulating EMT activity.

Onco Targets Ther 2019 26;12:2193-2203. Epub 2019 Mar 26.

National Key Clinical Department, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400000, People's Republic of China,

Introduction: Long noncoding RNAs (lncRNAs) play an important role in the origination and progression of hepatocellular carcinoma (HCC). However, the biological function of the long intergenic non-protein-coding RNA, LINC01296, in HCC remains unknown.

Methods: Here, we observed an increase in the expression levels of LINC01296 in HCC tissues and cell lines using reverse transcription quantitative PCR; these data were consistent with that obtained from The Cancer Genome Atlas database. Read More

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https://www.dovepress.com/linc01296-promotes-proliferation-m
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http://dx.doi.org/10.2147/OTT.S197338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441465PMC
March 2019
1 Read

Delayed remission following sequential infusion of humanized CD19- and CD22-modified CAR-T cells in a patient with relapsed/refractory acute lymphoblastic leukemia and prior exposure to murine-derived CD19-directed CAR-T cells.

Onco Targets Ther 2019 25;12:2187-2191. Epub 2019 Mar 25.

Department of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China,

Background: CD19-modified CAR-T cells greatly influence responses in patients with relapsed/refractory acute lymphoblastic leukemia (ALL). However, recurrence remains a challenge, and reinfusion of CAR-T cells is not always effective. Sequential infusion of humanized CD19-modified and CD22-modified CAR-T cells may overcome this issue and induce remission. Read More

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http://dx.doi.org/10.2147/OTT.S189103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438143PMC
March 2019
1 Read
1.342 Impact Factor

A case of small-cell lung cancer with adrenocorticotropic hormone deficiency induced by nivolumab.

Onco Targets Ther 2019 25;12:2181-2186. Epub 2019 Mar 25.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Anti-programmed death-1 (anti-PD-1) monoclonal antibodies, such as nivolumab, have been used for the treatment of various types of cancers, and excellent efficacy has been shown in some patients. The adverse effects of anti-PD-1 antibodies relating to autoimmunity are different from traditional chemotherapeutic drugs and may involve many organs including the endocrine system. We herein describe a case of adrenocorticotropic hormone deficiency during the treatment of advanced small-cell lung cancer, probably caused by nivolumab-induced hypophysitis. Read More

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http://dx.doi.org/10.2147/OTT.S194094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438139PMC

The role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy.

Onco Targets Ther 2019 25;12:2171-2180. Epub 2019 Mar 25.

Department of Breast Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China,

Background: IRAK1 has been shown to be abnormally expressed in a set of tumors leading to tumorigenesis and progression. IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel. However, the exact role of IRAK1 in neoadjuvant chemotherapy (NCT) for breast cancer remains unclear. Read More

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https://www.dovepress.com/the-role-of-irak1-in-breast-cancer
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http://dx.doi.org/10.2147/OTT.S185662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438138PMC
March 2019
1 Read

Weekly alternate intensive regimen FIrB/FOx in metastatic colorectal cancer patients: an update from clinical practice.

Onco Targets Ther 2019 25;12:2159-2170. Epub 2019 Mar 25.

Medical Oncology, St Salvatore Hospital, University of L'Aquila, L'Aquila, Italy,

Background: Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting interesting results in terms of received dose intensities (rDIs) and safety.

Methods: We reported a retrospective update of 85 patients treated with FIrB/FOx, an intensive regimen of 5-fluorouracil, bevacizumab, and weekly alternate irinotecan and oxaliplatin, to confirm its feasibility in "real life". Read More

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http://dx.doi.org/10.2147/OTT.S194745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438145PMC
March 2019
1 Read

miR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9.

Onco Targets Ther 2019 22;12:2149-2157. Epub 2019 Mar 22.

Department of General Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, People's Republic of China,

Background: Liver cancer was the fourth leading cause of cancer-related death in 2015. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. miR-1-3p plays important roles in cancer, including prostate, bladder, lung cancer, and colorectal carcinoma. Read More

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https://www.dovepress.com/mir-1-3p-suppresses-proliferation-
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http://dx.doi.org/10.2147/OTT.S197326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434909PMC
March 2019
6 Reads

CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer.

Onco Targets Ther 2019 22;12:2137-2147. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China,

Background: The disordered cell cycle and dysregulated expression of numerous oncogenes involved in tumor-relevant processes are highly related to the tumorigenesis of cervical cancer. Cyclin-dependent kinase 7 (CDK7) constitutes the indispensable catalytic subunit of CDK-activating kinase (CAK), which is required for both cell cycle transition and transcriptional regulation. However, research regarding the antitumor effects of CDK7 inhibition in cervical cancer remains unclear. Read More

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http://dx.doi.org/10.2147/OTT.S195655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434917PMC
March 2019
1.342 Impact Factor

Research status and progress of the RNA or protein biomarkers for prostate cancer.

Onco Targets Ther 2019 22;12:2123-2136. Epub 2019 Mar 22.

Department of Anesthesia, The Second Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Prostate cancer is a kind of male malignancy. Recently, a large number of studies have reported many potential biomarkers for the diagnosis and prognosis of prostate cancer. In this literature review, we have collected a number of potential biomarkers for prostate cancer reported in the last 5 years. Read More

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http://dx.doi.org/10.2147/OTT.S194138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434918PMC

SUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer.

Onco Targets Ther 2019 21;12:2115-2121. Epub 2019 Mar 21.

Department of Neurosurgery, Shandong Province Qianfoshan Hospital of Shandong University, Jinan 250014, Shandong, People's Republic of China,

Purpose: The objective of this study was to explore the association between KRAS mutation status and PET/CT metabolic parameters in colorectal cancer (CRC) patients.

Materials And Methods: One hundred and sixty-four CRC patients were enrolled in this study and received PET/CT examination before operation, then KRAS mutation status was analyzed through pathologically confirmed CRC samples. The association between tumor clinical characteristics and PET/CT metabolic parameters, including maximum standardized uptake value (SUVmax), SUVmean, and metabolic tumor volume (MTV), and KRAS mutation status was analyzed using chi-squared tests, Mann-Whitney tests, and logistic regression analysis. Read More

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http://dx.doi.org/10.2147/OTT.S196725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433102PMC
March 2019
2 Reads

Elevated nuclear auto-antigenic sperm protein promotes melanoma progression by inducing cell proliferation.

Onco Targets Ther 2019 21;12:2105-2113. Epub 2019 Mar 21.

Department of Neurology, Hefei Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, People's Republic of China,

Background: Nuclear auto-antigenic sperm protein (NASP) has been implicated in tumorigenesis. However, its role in melanoma is still unclear.

Materials And Methods: In the present study, we detected the mRNA and protein level of NASP in melanoma cell lines and tissues. Read More

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http://dx.doi.org/10.2147/OTT.S197813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433116PMC

Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway.

Onco Targets Ther 2019 19;12:2079-2088. Epub 2019 Mar 19.

Oncology Department, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou, Henan Province, China,

Purpose: NK/T-cell neoplasms are rare, highly aggressive, and insensitive to chemotherapy. These lymphomas have a poor prognosis, with patients being vulnerable to relapse. Hence, there is a need for alternative treatments. Read More

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http://dx.doi.org/10.2147/OTT.S187280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433108PMC

Effect of 21-gene recurrence score in decision-making for surgery in early stage breast cancer.

Onco Targets Ther 2019 19;12:2071-2078. Epub 2019 Mar 19.

Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, People's Republic of China,

Aim: We aimed to assess the role of 21-gene recurrence score (RS) in the decision-making for surgical treatment in early stage breast cancer and compared the outcomes between breast-conserving surgery (BCS) and mastectomy (MAST) among various 21-gene RS groups.

Methods: We included patients with stage T1-2M0M0 and estrogen receptor-positive breast invasive ductal carcinoma who underwent BCS + radiotherapy or MAST between 2004 and 2012 as part of the Surveillance, Epidemiology, and End Results program. Data were analyzed using binomial logistic regression, multivariate Cox proportional hazards models, and propensity score matching (PSM). Read More

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http://dx.doi.org/10.2147/OTT.S199625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433114PMC
March 2019
1 Read

Nonhomologous end joining key factor XLF enhances both 5-florouracil and oxaliplatin resistance in colorectal cancer.

Onco Targets Ther 2019 20;12:2095-2104. Epub 2019 Mar 20.

Department of Anesthesiology, Jilin Cancer Hospital, Changchun, Jilin 130021, China,

Background: Colorectal cancer (CRC) is the third commonly diagnosed cancer with a high risk of death. After curative surgery, 40% of patients will have metastases or develop recurrence. Therefore, chemotherapy is significantly responsible as the major therapy method. Read More

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http://dx.doi.org/10.2147/OTT.S192923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430989PMC
March 2019
1 Read

Two cases of lymphangitic carcinomatosis as the primary symptom of colorectal carcinoma that achieved complete remission using combination anti-EGFR antibody therapy.

Onco Targets Ther 2019 20;12:2089-2093. Epub 2019 Mar 20.

Medical Oncology, Showa University Koto Toyosu Hospital, Tokyo, Japan,

Clinicians often encounter cases of pulmonary lymphangitic carcinomatosis when treating patients with cancer. When such a condition develops before the diagnosis of cancer, its diagnosis is often challenging. Herein, we report about two patients with colorectal carcinoma diagnosed after the identification of lymphangitic carcinomatosis, which achieved complete remission with combination anti-epidermal growth factor receptor (anti-EGFR) antibody therapy. Read More

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http://dx.doi.org/10.2147/OTT.S194224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430998PMC
March 2019
1 Read

Elevated expression of microRNA-328-3p suppresses aggressive malignant behaviors via targeting matrix metalloprotease 16 in osteosarcoma.

Onco Targets Ther 2019 18;12:2063-2070. Epub 2019 Mar 18.

Department of Orthopaedics, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second Hospital, Huai'an, Jiangsu, People's Republic of China,

Background: A previous study indicated that microRNA(miR)-328-3p upregulation might be critical for resveratrol-mediated suppression of metastatic ability in human osteosarcoma, implying its potential role in this malignancy. However, the clinical significance and the biological functions of miR-328-3p in osteosarcoma remain unclear.

Methods: miR-328-3p expression in 88 pairs of osteosarcoma and matched non-cancerous bone tissues were detected by quantitative real-time PCR. Read More

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https://www.dovepress.com/elevated-expression-of-microrna-32
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http://dx.doi.org/10.2147/OTT.S195022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430066PMC
March 2019
2 Reads

Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date.

Authors:
Lee D Cranmer

Onco Targets Ther 2019 18;12:2047-2062. Epub 2019 Mar 18.

Division of Medical Oncology, University of Washington, Seattle, WA, USA,

Anthracyclines, and doxorubicin in particular, remain a mainstay of sarcoma therapy. Despite modest activity and significant toxicities, no cytotoxic monotherapy has yet yielded superior overall survival over doxorubicin for therapy of advanced soft tissue sarcomas in a randomized trial. Similarly, combination regimens have also been unable to overcome doxorubicin in terms of overall survival. Read More

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https://www.dovepress.com/spotlight-on-aldoxorubicin-inno-20
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http://dx.doi.org/10.2147/OTT.S145539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430065PMC
March 2019
10 Reads

Paradoxical effects of cellular senescence-inhibited gene involved in hepatocellular carcinoma migration and proliferation by ERK pathway and mesenchymal-like markers.

Onco Targets Ther 2019 15;12:2035-2046. Epub 2019 Mar 15.

Peking University Institute of Organ Transplantation, Peking University Center of Liver Cancer Diagnosis and Treatment, Beijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, 100044, China,

Background: Cellular senescence-inhibited gene (CSIG) strongly prolongs the progression of replicative senescence. However, roles and mechanisms of CSIG in tumor progression have not been studied widely.

Methods: Roles of CSIG in migration and proliferation of SMMC7721 and Huh7 cells were analyzed by transwell or cell viability assays, respectively. Read More

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https://www.dovepress.com/paradoxical-effects-of-cellular-se
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http://dx.doi.org/10.2147/OTT.S188449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421901PMC
March 2019
6 Reads

Microcalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes.

Onco Targets Ther 2019 15;12:2023-2033. Epub 2019 Mar 15.

Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China,

Background: Microcalcification is a very important diagnostic information in breast cancer. The purpose of this study was to determine the relationship of clinicopathological features and prognosis of breast cancer with microcalcification and to detect biomarkers related to the possible mechanisms of microcalcifications.

Patients And Methods: All 529 subjects with microcalcifications were selected from patients who had been examined using breast mammography. Read More

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http://dx.doi.org/10.2147/OTT.S187835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421899PMC

Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway.

Onco Targets Ther 2019 15;12:2011-2021. Epub 2019 Mar 15.

Department of Medical Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 200233 Shanghai, People's Republic of China,

Purpose: The aims of this study were to determine the effect of curcumin on osteosarcoma (OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic value of this pathway in OS.

Materials And Methods: We exposed a human OS cell line (MG-63) to different concentrations of curcumin. Then, we characterized the effects on MG-63 cells using assays (cell viability, colony formation, cell cycle, wound healing, invasion), flow cytometry, Western blot, immunohistochemical analyses, and tumor xenograft. Read More

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http://dx.doi.org/10.2147/OTT.S172909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421868PMC
March 2019
1 Read

Construction of prognostic microRNA signature for human invasive breast cancer by integrated analysis.

Onco Targets Ther 2019 15;12:1979-2010. Epub 2019 Mar 15.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,

Background: Despite the advances in early detection and treatment methods, breast cancer still has a high mortality rate, even in those patients predicted to have a good prognosis. The purpose of this study is to identify a microRNA signature that could better predict prognosis in breast cancer and add new insights to the current classification criteria.

Materials And Methods: We downloaded microRNA sequencing data along with corresponding clinicopathological data from The Cancer Genome Atlas (TCGA). Read More

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http://dx.doi.org/10.2147/OTT.S189265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430069PMC

Downregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling.

Onco Targets Ther 2019 14;12:1965-1977. Epub 2019 Mar 14.

GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou 511436, China,

Background: Recently, the biggest challenge in the treatment of breast cancer is the metastasis of breast cancer cells. Multiple myeloma SET protein (MMSET), a histone lysine methyltransferase, overexpressed in various human cancers, was reported to be associated with carcinogenesis of human cancers.

Methods: Expression of MMSET in breast cancer cell lines and tissues was quantified by real-time PCR and Western blotting. Read More

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http://dx.doi.org/10.2147/OTT.S196430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421877PMC
March 2019
2 Reads

Elevated apolipoprotein B predicts poor postsurgery prognosis in patients with hepatocellular carcinoma.

Onco Targets Ther 2019 12;12:1957-1964. Epub 2019 Mar 12.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China,

Aims: To date, curative resection remains to be the most optimal therapeutic choice of hepatocellular carcinoma (HCC), though the overall survival (OS) remains extremely unsatisfactory. To better manage the HCC patients, we evaluated the prognosis predicting values of apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) on the long-time survival of patients who underwent surgical treatment in this study.

Methods: A subgroup of 164 patients from our previously described follow-up cohort were enrolled in this study, of whom the pre-surgery ApoB and LDL-C measurements were available. Read More

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http://dx.doi.org/10.2147/OTT.S192631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420103PMC
March 2019
1.342 Impact Factor

Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.

Onco Targets Ther 2019 12;12:1947-1956. Epub 2019 Mar 12.

Department of Cardiothoracic Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, People's Republic of China,

Purpose: To explore the effects of hypoxic non-small-cell lung cancer (NSCLC)-derived exosomes on NSCLC resistance to cisplatin.

Materials And Methods: Exosomes were isolated by differential centrifugation and characterized by transmission electron microscope and Western blotting. Quantitative real-time PCR was used to measure miR-21 levels. Read More

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https://www.dovepress.com/hypoxic-non-small-cell-lung-cancer
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http://dx.doi.org/10.2147/OTT.S186922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420102PMC
March 2019
5 Reads
1.342 Impact Factor

Mechanisms of drug resistance in acute myeloid leukemia.

Onco Targets Ther 2019 11;12:1937-1945. Epub 2019 Mar 11.

Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, People's Republic of China,

Acute myeloid leukemia (AML) is a kind of malignant hematopoietic system disease characterized by abnormal proliferation, poor cell differentiation, and infiltration of bone marrow, peripheral blood, or other tissues. To date, the first-line treatment of AML is still based on daunorubicin and cytosine arabinoside or idarubicin and cytosine arabinoside regimen. However, the complete remission rate of AML is still not optimistic, especially in elderly patients, and the recurrence rate after complete remission is still high. Read More

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http://dx.doi.org/10.2147/OTT.S191621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417008PMC
March 2019
2 Reads

Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells.

Onco Targets Ther 2019 8;12:1929-1936. Epub 2019 Mar 8.

Department of Nuclear Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, P.R. China,

Introduction: Poor prognosis of gastric cancer (GC) has partly been a result of late diagnosis due to nonspecific symptoms in the early stages. The overall survival rate of patients with GC is quite low. Here, we presented the functional role and potential mechanism of long noncoding RNA STXBP5-AS1 in GC. Read More

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http://dx.doi.org/10.2147/OTT.S194463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415728PMC
March 2019
1 Read

Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma.

Onco Targets Ther 2019 8;12:1917-1927. Epub 2019 Mar 8.

Department of Pathology, School of Basic Medical Sciences, Zhengzhou University and First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, China,

Background: The gene, a highly conserved member of the Myb transcription-factor family, has been implicated in the genesis and progression of many types of tumors.

Methods: We analyzed the expression of MYBL2 and Ki67 in tissue samples of esophageal squamous-cell carcinoma (ESCC) patients by immunohistochemistry. We further analyzed the effect of MYBL2 on cell proliferation and DNA replication using a CCK8 assay, 5-ethynyl-2'-deoxyuridine-retention assay, flow-cytometry analysis, real-time quantitative PCR, Western blot, and a xenograft model of ESCC cells in nude mice. Read More

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http://dx.doi.org/10.2147/OTT.S190145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415733PMC
March 2019
1.342 Impact Factor

lncRNAs as potential molecular biomarkers in the clinicopathology and prognosis of cholangiocarcinoma: a systematic review and meta-analysis.

Onco Targets Ther 2019 8;12:1905-1915. Epub 2019 Mar 8.

Clinical College, Peking University Shenzhen Hospital, Anhui Medical University, Hefei, Anhui, 230032, P.R. China,

Background: Cholangiocarcinoma (CCA) is the second most common fatal primary hepatobiliary malignant carcinoma, characterized by early invasion and extremely poor outcomes. It is therefore necessary to identify a novel biomarker to better diagnose CAA and predict its prognosis. Recently, emerging evidence has revealed that some lncRNAs play an important role in the tumorigenesis and progression of CAA. Read More

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http://dx.doi.org/10.2147/OTT.S188134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415731PMC
March 2019
1 Read

MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA.

Onco Targets Ther 2019 8;12:1893-1903. Epub 2019 Mar 8.

Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China,

Purpose: Angiogenesis actively contributes to tumor growth and metastasis. MACC1 was reported to be associated with tumor progression. In the present study, we aimed to investigate the expression and role of MACC1 in cholangiocarcinoma (CCA) and its correlation with angiogenesis. Read More

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http://dx.doi.org/10.2147/OTT.S197319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415730PMC
March 2019
1 Read

Neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer: a systematic review and meta-analysis.

Onco Targets Ther 2019 7;12:1881-1891. Epub 2019 Mar 7.

Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China,

Aim: This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer.

Methods: A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant chemotherapy plus radical surgery vs radical surgery alone. Read More

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http://dx.doi.org/10.2147/OTT.S186451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413756PMC
March 2019
1 Read

ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway.

Onco Targets Ther 2019 7;12:1867-1880. Epub 2019 Mar 7.

Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China,

Purpose: Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration in the brain. This study aims to investigate the specific anticancer activities and mechanisms of DMAMCL in glioma cells. Read More

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https://www.dovepress.com/ros-generation-and-autophagosome-a
Publisher Site
http://dx.doi.org/10.2147/OTT.S195329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413739PMC
March 2019
13 Reads

Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment.

Onco Targets Ther 2019 7;12:1857-1865. Epub 2019 Mar 7.

Experimental Teaching Center, School of Nursing, Jilin University, Changchun, Jilin, China,

Glioblastoma multiforme (GBM) is the most common and aggressive adult primary central nervous system tumor. Unfortunately, GBM is resistant to the classic chemotherapy drug, temozolomide (TMZ). As well as its classic DNA-targeting effects, the off-target effects of TMZ can have pro-survival or pro-death roles and regulate GBM chemoradiation sensitivity. Read More

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http://dx.doi.org/10.2147/OTT.S194770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413742PMC