3,397 results match your criteria OncoTargets and Therapy [Journal]


Combining data from TCGA and GEO databases and reverse transcription quantitative PCR validation to identify gene prognostic markers in lung cancer.

Onco Targets Ther 2019 21;12:709-720. Epub 2019 Jan 21.

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China,

Background: The aim of this study was to predict and explore the possible mechanism and clinical value of genetic markers in the development of lung cancer with a combined database to screen the prognostic genes of lung cancer.

Materials And Methods: Common differential genes in two gene expression chips (GSE3268 and GSE10072 datasets) were investigated by collecting and calculating from Gene Expression Omnibus and The Cancer Genome Atlas databases using R language. Five markers of gene composition (ribonucleotide reductase regulatory subunit M2 [RRM2], trophoblast glycoprotein [TPBG], transmembrane protease serine 4[TMPRFF4], chloride intracellular channel 3 [CLIC3], and WNT inhibitory factor-1 [WIF1]) were found by the stepwise Cox regression function when we further screened combinations of gene models, which were more meaningful for prognosis. Read More

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https://www.dovepress.com/combining-data-from-tcga-and-geo-d
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http://dx.doi.org/10.2147/OTT.S183944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345189PMC
January 2019
2 Reads

LncRNA SNHG16 drives proliferation and invasion of papillary thyroid cancer through modulation of miR-497.

Onco Targets Ther 2019 18;12:699-708. Epub 2019 Jan 18.

Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, ErDao District, Changchun 13033, China,

Background: Long noncoding small nucleolar RNA host gene 16 (SNHG16) has been shown to play an oncogenic role in multiple cancers. However, the biological roles and mechanism of SNHG16 action in the regulation of papillary thyroid cancer (PTC) remains unknown. The aims of this study were to investigate the roles and the possible mechanism of SNHG16 in PTC progression. Read More

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http://dx.doi.org/10.2147/OTT.S186923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343509PMC
January 2019
1 Read

Expression of NR1H3 in endometrial carcinoma and its effect on the proliferation of Ishikawa cells in vitro.

Onco Targets Ther 2019 18;12:685-697. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China,

Purpose: Our study aimed to investigate the expression of NR1H3 in endometrial carcinoma, its effect on the proliferation of endometrial carcinoma cells in vitro, and the underlying mechanism of this effect.

Materials And Methods: Immunohistochemistry of paraffin-embedded, sectioned specimens and of a tissue microarray was conducted to estimate the expression of NR1H3 (liver X receptors α: LXRα) and NR1H2 (liver X receptors β: LXRβ) in endometrial carcinoma tissues. The subcellular localization of NR1H3 in the endometrial carcinoma cell line Ishikawa was determined by immunofluorescence. Read More

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http://dx.doi.org/10.2147/OTT.S180534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343513PMC
January 2019
2 Reads

Role of radiotherapy in the treatment of metastatic head and neck cancer.

Onco Targets Ther 2019 18;12:677-683. Epub 2019 Jan 18.

Department of Radiation Oncology, Hospital Universitario Virgen de la Victoria, Málaga, Spain,

In metastatic or locally advanced head and neck tumors that present in frail patients or after chemotherapy progression, radiotherapy is normally used as a palliative treatment, with a high rate of symptom palliation and improvement in quality of life. However, there is controversy about what the optimal regimen is. Moreover, despite the poor prognosis of metastatic head and neck cancer, different retrospective studies have shown that a minority of patients with oligometastatic disease experience prolonged disease-free survival after adding curative radiotherapy treatment to the metastatic disease and/or primary tumor. Read More

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http://dx.doi.org/10.2147/OTT.S181697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343506PMC
January 2019

Comparing short-time outcomes of three-dimensional and two-dimensional totally laparoscopic surgery for colon cancer using overlapped delta-shaped anastomosis.

Onco Targets Ther 2019 18;12:669-675. Epub 2019 Jan 18.

Department of Colorectal Surgery, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing 100021, People's Republic of China,

Purpose: Overlapped delta-shaped anastomosis is a newly developed intracorporeal procedure in totally laparoscopic surgery for colon cancer. We explored the safety and efficacy of three-dimensional (3D) totally laparoscopic surgery for colon cancer using overlapped anastomosis and compared its short-term outcomes with those of two-dimensional (2D) surgery.

Materials And Methods: From January 2016 to March 2018, 97 colon cancer patients were grouped into the 3D group (43 patients) and the 2D group (54 patients); they underwent totally laparoscopic surgery for colon cancer using overlapped anastomosis by 3D and 2D laparoscopy, respectively. Read More

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http://dx.doi.org/10.2147/OTT.S187535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343507PMC
January 2019

The lncRNA ZEB2-AS1 is upregulated in gastric cancer and affects cell proliferation and invasion via miR-143-5p/HIF-1α axis.

Onco Targets Ther 2019 18;12:657-667. Epub 2019 Jan 18.

Department of Emergency, The First Affiliated Hospital of Xi'an Medical University, Xi'an City, Shaanxi Province, China,

Background: Growing evidence has implicated the important role of the long non-coding RNAs (lncRNAs) in gastric cancer progression. In this study, we examined the expression of lncRNA zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) in gastric cancer tissues and elucidated the molecular mechanisms underlying ZEB2-AS1-mediated gastric cancer progression.

Methods: Quantitative real-time PCR measured the gene expression level; CCK-8, colony formation and cell invasion assays determined gastric cancer cell proliferation, growth and invasion, respectively; the xenograft nude mice model was used to determine in vivo tumor growth; Bioinformatics analysis and luciferase reporter assay determined the downstream targets of ZEB2-AS1 and miR-143-5p. Read More

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http://dx.doi.org/10.2147/OTT.S175521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343511PMC
January 2019

Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma.

Onco Targets Ther 2019 18;12:647-656. Epub 2019 Jan 18.

Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China,

Background: Although increasing evidence has demonstrated important roles for long non-coding RNAs (lncRNAs) in cancer development, their functions in oral squamous cell carcinoma (OSCC) growth remain largely unknown. Therefore, we aimed to investigate the role of LINC00662 in OSCC.

Methods: The expression of LINC00662 in 61 OSCC tissues and four OSCC cell lines were detected by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.2147/OTT.S188691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343512PMC
January 2019

Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies.

Onco Targets Ther 2019 18;12:635-645. Epub 2019 Jan 18.

Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia,

Human malignancies are often the result of overexpressed and constitutively active receptor and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor-driven pathways. Several tyrosine kinases (ie, EGFR, FGFR, PDGFR, VEGFR), are aberrantly activated in most common tumors, including leukemia, glioblastoma, gastrointestinal stromal tumors, non-small-cell lung cancer, and head and neck cancers. Iclusig™ (ponatinib, previously known as AP24534) is an orally active multi-tyrosine kinase inhibitor and is currently approved by the US Food and Drug Administration for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, specifically targeting the BCR-ABL gene mutation, T315I. Read More

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https://www.dovepress.com/ponatinib-a-novel-multi-tyrosine-k
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http://dx.doi.org/10.2147/OTT.S189391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343508PMC
January 2019
3 Reads

RAP80 expression in breast cancer and its relationship with apoptosis in breast cancer cells.

Onco Targets Ther 2019 18;12:625-634. Epub 2019 Jan 18.

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China,

Background: RAP80 is a member of BRCA1-A complex, which plays an important role in regulating the cell cycle checkpoint and DNA damage repair in the nucleus.

Method: We investigated RAP80 expression in breast cancer and its paired normal breast tissues to further analyze its role in the biological behavior of breast cancer cells.

Results: RAP80 expression in breast cancer (62. Read More

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https://www.dovepress.com/rap80-expression-in-breast-cancer-
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http://dx.doi.org/10.2147/OTT.S186981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343510PMC
January 2019
2 Reads

Ureteral metastasis of non-small-cell lung cancer: a case report.

Onco Targets Ther 2019 15;12:619-623. Epub 2019 Jan 15.

Department of Lung Cancer Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China,

Lung cancer is one of the most common causes of cancer-related death. Most of them already have distant metastasis at the time of diagnosis, but ureteral metastasis is extremely rare. Herein, we reported a lung cancer patient with a metastatic lesion from lung cancer at the distal end of the ureter. Read More

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http://dx.doi.org/10.2147/OTT.S189334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339466PMC
January 2019

Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy.

Onco Targets Ther 2019 15;12:609-617. Epub 2019 Jan 15.

Clinical Laboratory, Zhangjiagang First People's Hospital, Suzhou University, Suzhou, Jiangsu 215600, People's Republic of China,

Background: Effectiveness of clinical therapy such as chemotherapy for solid tumors is limited by acquired drug resistance and side effects. Available antitumor immunity methods showed promising prospect of cancer therapy. However, more drug targets for boosting antitumor immunity still need to be explored and selective and effective compounds are yet to be developed. Read More

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https://www.dovepress.com/pharmacological-inhibition-of-usp7
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http://dx.doi.org/10.2147/OTT.S182806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339463PMC
January 2019
3 Reads

miR-4262, low level of which predicts poor prognosis, targets proto-oncogene CD163 to suppress cell proliferation and invasion in gastric cancer.

Onco Targets Ther 2019 15;12:599-607. Epub 2019 Jan 15.

Department of Radiotherapy, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China,

Background: miR-4262 was identified as a tumor promoter in several cancers, but its exact role in gastric carcinoma is still largely unknown.

Methods: The expression of miR-4262 was detected in gastric cancer tissues. Different concentrations of miR-4262 mimic and miR-4262 antagomir were respectively transfected into primary gastric carcinoma cells. Read More

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https://www.dovepress.com/mir-4262-low-level-of-which-predic
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http://dx.doi.org/10.2147/OTT.S187881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339465PMC
January 2019
3 Reads

Scutellarin inhibits the metastasis and cisplatin resistance in glioma cells.

Onco Targets Ther 2019 15;12:587-598. Epub 2019 Jan 15.

Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China,

Background: Scutellarin is a natural flavone compound that possesses anti-tumor and chemosensitization effects in several cancers. However, the effects of scutellarin on metastasis and chemoresistance in glioma have not been illustrated.

Methods: Glioma cells were treated with scutellarin in the presence or absence of LY294002. Read More

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https://www.dovepress.com/scutellarin-inhibits-the-metastasi
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http://dx.doi.org/10.2147/OTT.S187426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339467PMC
January 2019
1 Read

Effect of CD44st and HER2 expression on the postoperative prognosis of breast cancer patients.

Onco Targets Ther 2019 15;12:577-585. Epub 2019 Jan 15.

Department of Oncology, The Second People's Hospital of Lianyungang (Lianyungang Hospital affiliated to Bengbu Medical College), Lianyungang, Jiangsu 222000, China,

Objective: CD44st is a member of the CD44 family; abnormal expression of some CD44 isoforms are closely associated with axillary lymph node metastasis, cancer progression, and patients' prognosis. The objective of this study is to investigate the correlation between the expression of CD44st and HER2 in breast cancer and the effect on patients' prognosis.

Methods: Primers were designed to target the CD44st mRNA (Gene Bank No FJ216964) which has been newly identified in a drug-resistant breast cancer cell line. Read More

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https://www.dovepress.com/effect-of-cd44st-and-her2-expressi
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http://dx.doi.org/10.2147/OTT.S180972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339464PMC
January 2019
3 Reads

Comprehensive analysis of potential prognostic genes for the construction of a competing endogenous RNA regulatory network in hepatocellular carcinoma.

Onco Targets Ther 2019 14;12:561-576. Epub 2019 Jan 14.

Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China,

Background: Hepatocellular carcinoma (HCC) is an extremely common malignant tumor with worldwide prevalence. The aim of this study was to identify potential prognostic genes and construct a competing endogenous RNA (ceRNA) regulatory network to explore the mechanisms underlying the development of HCC.

Methods: Integrated analysis was used to identify potential prognostic genes in HCC with R software based on the GSE14520, GSE17548, GSE19665, GSE29721, GSE60502, and the Cancer Genome Atlas databases. Read More

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http://dx.doi.org/10.2147/OTT.S188913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338110PMC
January 2019

Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies.

Onco Targets Ther 2019 11;12:549-559. Epub 2019 Jan 11.

Department of Spine and Joint Surgery, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China,

Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypo-methylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study. Read More

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http://dx.doi.org/10.2147/OTT.S192234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334784PMC
January 2019
1.342 Impact Factor

Should we apply sorafenib in hepatocellular carcinoma patients with microvascular invasion after curative hepatectomy?

Onco Targets Ther 2019 11;12:541-548. Epub 2019 Jan 11.

Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China,

Objective: Microvascular invasion (MVI) has been proved to be an independent risk factor for the recurrence of HCC. If promptly treated, the recurrence rate can be reduced and the total survival time can be prolonged. The aim of this study is to analyze the effect of sorafenib on the clinical outcomes in HCC patients with MVI after curative hepatectomy. Read More

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http://dx.doi.org/10.2147/OTT.S187357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334782PMC
January 2019

Merkel cell carcinoma of the thigh: case report and review of the literature.

Onco Targets Ther 2019 11;12:535-540. Epub 2019 Jan 11.

Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China,

Background: Merkel cell carcinoma (MCC) is a kind of cutaneous neuroendocrine cancer with a poor prognosis. It is characterized by a high rate of recurrence and metastases, including distant metastases and regional nodal metastases. Clinically, MCC often manifests as obvious single painless hard nodules visible in sun irradiation of diameter <2 cm and not uncommonly >2 cm, with rapid growth and metastases, especially lymph node metastases. Read More

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https://www.dovepress.com/merkel-cell-carcinoma-of-the-thigh
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http://dx.doi.org/10.2147/OTT.S182169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334783PMC
January 2019
3 Reads

Clinical significance of miR-195 in hepatocellular carcinoma and its biological function in tumor progression.

Onco Targets Ther 2019 10;12:527-534. Epub 2019 Jan 10.

Department of Laboratory Medicine, People's Hospital of Yutai County, Shandong 272300, People's Republic of China.

Background: Hepatocellular carcinoma (HCC) is one of the most lethal cancer types all over the world. Chronic viral hepatitis B and hepatitis C are risk factors that are associated with the development of HCC. The aim of this study is to identify the diagnostic role of serum miR-195 in HCC. Read More

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http://dx.doi.org/10.2147/OTT.S190108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330974PMC
January 2019

Correlation between high-resolution computed tomography lung nodule characteristics and EGFR mutation in lung adenocarcinomas.

Onco Targets Ther 2019 10;12:519-526. Epub 2019 Jan 10.

Department of Geriatrics, Linyi People's Hospital, Linyi 276000, China,

Background: The aim of this study was to investigate the correlation of EGFR mutation on the high-resolution computed tomography (HRCT) features in lung adenocarcinoma.

Patients And Methods: A total of 121 patients were diagnosed with lung adenocarcinoma from January 2014 to December 2016. The correlation of indexes (gender, age, tumor diameter, and EGFR mutation) was analyzed based on the HRCT characteristics of lung adenocarcinoma. Read More

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http://dx.doi.org/10.2147/OTT.S184217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330973PMC
January 2019

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling.

Onco Targets Ther 2019 9;12:509-518. Epub 2019 Jan 9.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China,

Background: There are few clinical challenges associated with the treatment of colorectal cancer (CRC). Studies have shown that TGF-β plays a crucial role in CRC. Importantly, celastrol, a major components of the root extract of the traditional Chinese herb , has been shown to inhibit the growth, adhesion, and metastasis of human CRC cells through the inhibition of TGF-β1/Smad signaling. Read More

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https://www.dovepress.com/celastrol-inhibits-colorectal-canc
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http://dx.doi.org/10.2147/OTT.S187817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331187PMC
January 2019
3 Reads

Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition.

Onco Targets Ther 2019 9;12:495-508. Epub 2019 Jan 9.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China,

Background: Rently, the incidence of bladder cancer has been on the rise. Accumulating researches have been conducted to clarify the molecular mechanisms and potential therapeutic targets of bladder cancer. The present study aims to explore the regulatory mechanism of the urothelial carcinoma-associated 1 (UCA1)-miR-582-5p-ATG7 axis in bladder cancer. Read More

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https://www.dovepress.com/long-noncoding-rna-uca1-targets-mi
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http://dx.doi.org/10.2147/OTT.S183940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331189PMC
January 2019
3 Reads
1.342 Impact Factor

Diagnostic significance of miR-210 as a potential tumor biomarker of human cancer detection: an updated pooled analysis of 30 articles.

Onco Targets Ther 2019 9;12:479-493. Epub 2019 Jan 9.

Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Peking University Shenzhen, Shenzhen 518038, Guangdong, China,

A large number of studies have explored the diagnostic value of miR-210 as a potential diagnostic cancer biomarker to detect various cancers in patients. However, the results of its diagnostic accuracy and reliability in individual studies are still inconsistent. Therefore, we conducted this updated pooled analysis to derive a more reliable conclusion of the overall accuracy of miR-210 in cancer detection and diagnosis. Read More

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http://dx.doi.org/10.2147/OTT.S184564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331190PMC
January 2019

The anthelmintic drug flubendazole induces cell apoptosis and inhibits NF-κB signaling in esophageal squamous cell carcinoma.

Onco Targets Ther 2019 9;12:471-478. Epub 2019 Jan 9.

Department of Emergency Surgery, The Affiliated Huaian No 1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu, China,

Background And Objectives: The nuclear factor kappa B (NF-κB) signaling is activated in esophageal squamous cell carcinoma (ESCC) and can be used as a potential target for anti-ESCC drug discovery. In this study, we aimed to investigate the function of flubendazole as a novel NF-κB inhibitor in ESCC cells.

Materials And Methods: Cell Counting Kit-8 assay was carried out to assess cell viability of ESCC cells. Read More

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http://dx.doi.org/10.2147/OTT.S193206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331185PMC
January 2019
1.342 Impact Factor

Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.

Onco Targets Ther 2019 9;12:457-469. Epub 2019 Jan 9.

Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China,

Background: Lung cancer is the leading cause of cancer-related deaths. Survival rate improves significantly with early detection of lung cancer. Effective methods of early detection can reduce lung cancer mortality to a large extent as well as benefit the whole public health. Read More

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http://dx.doi.org/10.2147/OTT.S187734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331188PMC
January 2019
1 Read

Nodal staging score and adequacy of nodal staging.

Onco Targets Ther 2019 8;12:449-455. Epub 2019 Jan 8.

Nanjing Jiangbei People's Hospital, Nanjing 220000, People's Republic of China,

Aims: The number of lymph nodes (LNs) excised in patients with pathologic N0 is limited, and it is very likely that there will be recessive node disease after surgery, so they are at risk of understaging. The purpose of the present study is to develop a nodal staging score (NSS) in a mathematical way to assess the likelihood that a pathologic N0 gastric cancer (GCa) patient has, indeed, no occult nodal disease after surgery.

Patients And Methods: A total of 14,033 stage I-III GCa patients were identified from Surveillance, Epidemiology and End Results database for analysis. Read More

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http://dx.doi.org/10.2147/OTT.S186642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329479PMC
January 2019

Complete response with fluorouracil and irinotecan with a BRAF and EGFR inhibitor in BRAF-mutated metastatic colorectal cancer: a case report.

Onco Targets Ther 2019 8;12:443-447. Epub 2019 Jan 8.

Department of Medical Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China,

Background: Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epidermal growth factor receptor (EGFR) and BRAF in patients with BRAF-mutated mCRC. Although the combination achieved higher progression-free survival (PFS) and disease control rates (DCRs), there was no complete response (CR) for the drug combination. Read More

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https://www.dovepress.com/complete-response-with-fluorouraci
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http://dx.doi.org/10.2147/OTT.S180845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329477PMC
January 2019
7 Reads

miR-302 cluster inhibits angiogenesis and growth of K562 leukemia cells by targeting VEGFA.

Onco Targets Ther 2019 8;12:433-441. Epub 2019 Jan 8.

Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China,

Background: miR-302 cluster has been reported as a tumor suppressor in many human cancers; yet, its function in chronic myeloid leukemia (CML) tumorigenesis remains largely unclear. The study was aimed to explore the functional roles of miR-302 cluster in CML progression.

Materials And Methods: Quantitative reverse transcriptase PCR and Western blot were performed to evaluate miR-302 cluster and vascular endothelial growth factor A (VEGFA) expression levels. Read More

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http://dx.doi.org/10.2147/OTT.S190146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329480PMC
January 2019
1 Read
1.342 Impact Factor

lncRNA CASC9 regulates cell migration and invasion in hemangioma endothelial cells by targeting miR-125a-3p/Nrg1.

Onco Targets Ther 2019 7;12:423-432. Epub 2019 Jan 7.

Department of Vascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, People's Republic of China,

Background: Despite being one of the most common benign tumors, the prevalence and pathogenesis of hemangiomas (HAs) are poorly understood. We aimed to identify the biological role of the long non-coding RNA (lncRNA) CASC9 in the HA-derived endothelial cell (HDECs) phenotype as well as elucidate the mechanism involved.

Methods: The expression of CASC9 was identified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Read More

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http://dx.doi.org/10.2147/OTT.S181914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327889PMC
January 2019

Long noncoding RNA SNHG16 induces sorafenib resistance in hepatocellular carcinoma cells through sponging miR-140-5p.

Onco Targets Ther 2019 4;12:415-422. Epub 2019 Jan 4.

Department of Hepatology, The First Hospital of Jilin University, Changchun City, Jilin Province, PR China,

Background: Sorafenib is widely used for treatment of hepatocellular carcinoma (HCC), but the acquired resistance remains a major obstacle for its application. Thus it is of critical importance to elucidate the molecular mechanisms underlying sorafenib resistance in HCC. This study aimed to determine the roles of long noncoding RNA SNHG16 in sorafenib-resistant HCC cells. Read More

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https://www.dovepress.com/long-noncoding-rna-snhg16-induces-
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http://dx.doi.org/10.2147/OTT.S175176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324603PMC
January 2019
3 Reads

Erratum: PLK1 as a potential prognostic marker of gastric cancer through MEK-ER K pathway on PDTX models [Corrigendum].

Authors:

Onco Targets Ther 2019 3;12:413. Epub 2019 Jan 3.

[This corrects the article on p. 6239 in vol. 11, PMID: 30288059. Read More

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http://dx.doi.org/10.2147/OTT.S199653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322700PMC
January 2019

rs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3'UTR in CHD5.

Onco Targets Ther 2019 3;12:405-412. Epub 2019 Jan 3.

Department of Clinical Laboratory, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China,

Background: Previous research indicated that overexpression of miRNA-211 could promote colorectal cancer cell growth by targeting tumor suppressive gene Chromodomain-helicase-DNA-binding protein 5 (CHD5) in human colon cancer (CC). Moreover, the function of the single-nucleotide polymorphism (SNP) located in the mature region of miR-211 has not been investigated. In this study, we found that SNP of rs187960998 in miR-211 was involved in the occurrence of CC by acting as a tumor suppressor by mal-regulation of its target gene . Read More

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http://dx.doi.org/10.2147/OTT.S180935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322703PMC
January 2019
1 Read

TRIM28 activates autophagy and promotes cell proliferation in glioblastoma.

Onco Targets Ther 2019 3;12:397-404. Epub 2019 Jan 3.

Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China,

Background: Tripartite motif-containing protein 28 (TRIM28) is a transcriptional corepressor involved in the regulation of several cancers, including glioma. It has been reported that TRIM28 takes part in the process of autophagy. However, its effect on the autophagy and cell proliferation in gliomas has not been elucidated. Read More

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http://dx.doi.org/10.2147/OTT.S188101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322701PMC
January 2019

CART cell therapy for prostate cancer: status and promise.

Onco Targets Ther 2019 3;12:391-395. Epub 2019 Jan 3.

Department of Urinary Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China,

In recent years, the, chimeric antigen receptor T (CAR-T) cell therapy as an adoptive immunotherapy has received great attention and made great breakthroughs. CAR-T cells show great specificity, targeting, and less major histocompatibility complex restriction in tumor immunotherapy, significantly different from traditional T cells. In spite of the progress of CART-T technology in the treatment of lymphoma, leukemia, and other blood system tumor, there are still many difficulties in the treatment of solid tumors by CAR-T technology. Read More

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http://dx.doi.org/10.2147/OTT.S185556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322708PMC
January 2019

Targeted neoadjuvant therapy in the HER-2-positive breast cancer patients: a systematic review and meta-analysis.

Onco Targets Ther 2019 3;12:379-390. Epub 2019 Jan 3.

Department of Nuclear Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China,

Aim: To evaluate efficacy and safety of lapatinib or trastuzumab alone or both plus chemotherapy for the treatment of breast cancer patients with positive HER-2 expression.

Methods: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, OVID, Embase, Chinese Biomedical Literature Database, and China Academic Journals Database were searched from 1994 through December 2017 using the keywords "breast cancer", "preoperative", "neo-adjuvant", "lapatinib", "pertuzumab", "Herceptin", and "trastuzumab".

Results: Meta-analysis found that pathological complete response (PCR; risk ratio [RR]=0. Read More

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http://dx.doi.org/10.2147/OTT.S183304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322707PMC
January 2019
1 Read

The progression of HMGB1-induced autophagy in cancer biology.

Onco Targets Ther 2019 31;12:365-377. Epub 2018 Dec 31.

Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China,

Autophagy is an important process of cellular degradation and has been proven to contribute to tumorigenesis. High-mobility group box 1 (HMGB1) is an abundant nonhistone protein that has been widely reported to play a central role in the induction of autophagy. In nucleus, HMGB1 upregulates the expression of HSP27 to induce autophagy. Read More

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http://dx.doi.org/10.2147/OTT.S185876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317470PMC
December 2018

Serum cytoskeleton-associated protein 4 as a biomarker for the diagnosis of hepatocellular carcinoma.

Onco Targets Ther 2019 31;12:359-364. Epub 2018 Dec 31.

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China,

Background: Alpha-fetoprotein (AFP) is the most commonly applied biomarker for diagnosis of hepatocellular carcinoma (HCC), but the low sensitivity and specificity limit its clinical application. Cytoskeleton-associated protein 4 (CKAP4) is a novel oncogenic protein involved in the development and progression of HCC. This study aimed to evaluate whether measurement of circulating CKAP4 could improve diagnostic accuracy for HCC. Read More

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https://www.dovepress.com/serum-cytoskeleton-associated-prot
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http://dx.doi.org/10.2147/OTT.S189425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317466PMC
December 2018
4 Reads

Comparison of the diagnostic performance of fluorescence in situ hybridization (FISH), nuclear matrix protein 22 (NMP22), and their combination model in bladder carcinoma detection: a systematic review and meta-analysis.

Onco Targets Ther 2019 31;12:349-358. Epub 2018 Dec 31.

Department of Clinical Laboratory, Affiliated Hospital & Clinical Medical College of Chengdu University, Chengdu, Sichuan, China,

Background: Emerging studies reported that combination of fluorescence in situ hybridization (FISH) and nuclear matrix protein 22 (NMP22) could increase the sensitivity and specificity of bladder carcinoma (BC) management. Nevertheless, the reports remain inconsistent. This meta-analysis was undertaken to evaluate the diagnostic performance of FISH, NMP22, and their combination model in BC. Read More

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http://dx.doi.org/10.2147/OTT.S186065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317485PMC
December 2018
1 Read

Combination of TPF regimen and cinobufotalin inhibits proliferation and induces apoptosis in human hypopharyngeal and laryngeal squamous cell carcinoma cells.

Onco Targets Ther 2019 31;12:341-348. Epub 2018 Dec 31.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China,

Background: Hypopharyngeal squamous cell carcinoma and laryngeal squamous cell carcinoma have a potential risk of metastasis and local recurrence. It is urgent to determine novel effective therapy.

Methods: UMSCC5 and FADU cells were treated with TPF regimen (a mixture comprising paclitaxel, cisplatin, and 5-fluorouracil), cinobufotalin, and combination. Read More

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http://dx.doi.org/10.2147/OTT.S185428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317469PMC
December 2018
1 Read

Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology.

Onco Targets Ther 2019 31;12:319-339. Epub 2018 Dec 31.

Department of Urology, Agios Savvas Cancer Hospital, Athens 11522, Greece,

Pleiotropy in biological systems and their targeting allows many pharmaceuticals to be used for multiple therapeutic purposes. Fully exploiting the therapeutic properties of drugs that are already marketed would be highly advantageous. This is especially the case in the field of oncology, where the ineffectiveness of typical anticancer agents is a common issue, while the development of novel anticancer agents is a costly and particularly time-consuming process. Read More

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http://dx.doi.org/10.2147/OTT.S182685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317484PMC
December 2018
2 Reads
1.342 Impact Factor

MiR-6991-3p is identified as a novel suppressor in the expansion and activation of myeloid-derived suppressor cells in hepatoma-bearing mice.

Onco Targets Ther 2019 28;12:309-317. Epub 2018 Dec 28.

Department of Gastroenterology, Huaihe Hospital of Henan University, Kaifeng 475000, China,

Objective: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells derived from bone marrow, which has a significant ability in inhibition of immune cell response. In this study, the role of miR-6991-3p in regulating function of MDSCs was investigated.

Methods: MDSCs were isolated from different tissues of the control and hepatoma-bearing mice, and then expression of miR-6991-3p was detected with qPCR. Read More

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http://dx.doi.org/10.2147/OTT.S185422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314317PMC
December 2018

Evaluating ivosidenib for the treatment of relapsed/refractory AML: design, development, and place in therapy.

Onco Targets Ther 2019 28;12:303-308. Epub 2018 Dec 28.

Department of Internal Medicine, The George Washington University School of Medicine, Washington, DC, USA,

Improvements in the last decade in understanding the molecular mechanisms underlying acute myeloid leukemia (AML) have emphasized that treatment regimens should be personalized with agents that can selectively target genetic abnormalities if present. Neomorphic mutations in isoform 1 of isocitrate dehydrogenase () result in the formation of the onco-metabolite -2-hydroxyglutarate, which drives leukemic transformation by affecting processes such as chromatin remodeling, the cellular defense against oxidative stress and cell survival. Preclinical studies with small molecule inhibitors have validated mutant IDH1 as a molecular target, and a recent Phase 1 clinical trial with the first mutant IDH1 inhibitor ivosidenib has prompted approval by the US Food and Drug Association for the treatment of patients with -mutated AML in the relapsed and refractory setting due to impressive results. Read More

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https://www.dovepress.com/evaluating-ivosidenib-for-the-trea
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http://dx.doi.org/10.2147/OTT.S182443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314316PMC
December 2018
6 Reads

Contribution of FPR and TLR9 to hypoxia-induced chemoresistance of ovarian cancer cells.

Onco Targets Ther 2019 28;12:291-301. Epub 2018 Dec 28.

Department of Pharmacy, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing 400042, China,

Background/purpose: The aim of this study was to investigate the role and mechanisms of the formyl peptide receptor (FPR) and the toll-like receptor 9 (TLR9) in hypoxia-induced chemoresistance of human ovarian cancer cells.

Materials And Methods: SKOV3 cells were exposed to hypoxia for 24 hours, the supernatant was collected to stimulate normoxia-cultured SKOV3, and the inhibition rate of cell growth was detected with CCK8 test. The agonist of TLR9 CpG ODN and the agonist of FPR fMLF were applied to investigate the chemosensitivity of SKOV3 cells to cisplatin. Read More

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http://dx.doi.org/10.2147/OTT.S190118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314315PMC
December 2018

CD4 CD25 regulatory T cells promote hepatocellular carcinoma invasion via TGF-β1-induced epithelial-mesenchymal transition.

Onco Targets Ther 2019 28;12:279-289. Epub 2018 Dec 28.

Department of Pathology, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, Harbin 150001, China,

Background: CD4 CD25 regulatory T cells (Tregs), a crucial component of the infiltration of immune cells in tumor microenvironment, are associated with progression and metastasis of hepatocellular carcinoma (HCC).

Methods: The mechanism of Tregs in the invasion and metastasis of HCC was investigated in vivo and in vitro using immunohistochemical analysis, western blot, and quantitative reverse transcription-PCR (qRT-PCR).

Results: Analysis of 78 clinical HCC samples indicated that high expression of Tregs was strongly associated with poor cancer-free survival and overall survival of patients. Read More

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https://www.dovepress.com/cd4-cd25-regulatory-t-cells-promot
Publisher Site
http://dx.doi.org/10.2147/OTT.S172417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314313PMC
December 2018
3 Reads

Should S-1 be better than capecitabine for patients with advanced gastric cancer in Asia? A systematic review and meta-analysis.

Onco Targets Ther 2019 27;12:269-277. Epub 2018 Dec 27.

Department of Pharmacy, Traditional Chinese Medical Hospital of Zhuji, Zhuji, China,

Background: S-1 or capecitabine (Cap) containing treatment is an increasingly used strategy in patients with advanced gastric cancer in Asia. It is unclear whether there is sufficient evidence to support which regimen is better.

Methods: A systematic review of retrospective studies and randomized controlled trials (RCTs) comparing S-1 with Cap containing treatment in advanced gastric cancer patients was performed. Read More

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http://dx.doi.org/10.2147/OTT.S187815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312060PMC
December 2018
1 Read

Evodiamine inactivates NF-κB and potentiates the antitumor effects of gemcitabine on tongue cancer both in vitro and in vivo.

Onco Targets Ther 2019 27;12:257-267. Epub 2018 Dec 27.

Department of Periodontology, School of Stomatology, Lanzhou University, Lanzhou, Gansu, China,

Objective: The aim of this study was to investigate whether evodiamine (EVO) could potentiate the antitumor activity of gemcitabine (GEM) in tongue cancer cells and determine its potential underlying mechanisms.

Materials And Methods: Human Tca8113 and CAL-27 tongue squamous carcinoma cell lines were treated with EVO and GEM in different sequences and doses, after which cell proliferation was measured. Drug interactions were analyzed using the Chou-Talalay method with CompuSyn software. Read More

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https://www.dovepress.com/evodiamine-inactivates-nf-kappab-a
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http://dx.doi.org/10.2147/OTT.S181062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312051PMC
December 2018
6 Reads

Erratum: Circ-DLG 1 promotes the proliferation of esophageal squamous cell carcinoma [Erratum].

Authors:

Onco Targets Ther 2019 27;12:255. Epub 2018 Dec 27.

[This corrects the article on p. 6723 in vol. 11, PMID: 30349305. Read More

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http://dx.doi.org/10.2147/OTT.S197970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312048PMC
December 2018

Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma.

Onco Targets Ther 2019 27;12:243-253. Epub 2018 Dec 27.

Institute of Orbital Disease, General Hospital of Chinese People's Armed Police Forces, Beijing, China,

Objective: This study aimed to investigate the relationship between VCP expression and the prognosis of orbital B-cell lymphoma patients and the influence of downregulation of VCP on the apoptosis and invasion abilities of lymphoma cells.

Methods: We recruited 66 orbital B-cell lymphoma patients. VCP expression in 66 samples of orbital B-cell lymphoma was determined by immunohistochemistry using monoclonal VCP antibodies. Read More

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http://dx.doi.org/10.2147/OTT.S182118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312057PMC
December 2018
1 Read

DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.

Onco Targets Ther 2019 28;12:233-241. Epub 2018 Dec 28.

Department of Central laboratory, The Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China.

Background: Cancer stem cells (CSCs) are responsible for all important characteristics of tumors. DEAD-box helicase 27 (DDX27) is a member of the DEAD-box RNA helicase family, and there have been only a few studies on DDX27 function in cancer cells. This study is aimed at exploring whether DDX27 has any relation to tumorigenesis of colorectal cancer (CRC) and elucidating the potential mechanism. Read More

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https://www.dovepress.com/dead-box-helicase-27-plays-a-tumor
Publisher Site
http://dx.doi.org/10.2147/OTT.S190814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314319PMC
December 2018
4 Reads
1.342 Impact Factor

The use of regorafenib for patients with refractory metastatic colorectal cancer in clinical practice.

Onco Targets Ther 2019 24;12:225-231. Epub 2018 Dec 24.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea,

Aim: Patients in clinical practice are relatively vulnerable compared to those enrolled in clinical trials. We focused on analyzing the pattern of regorafenib use in routine clinical practice, which included initial starting dose and follow-up schedule. We also evaluated the efficacy and safety according to clinical regimen. Read More

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http://dx.doi.org/10.2147/OTT.S187621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309775PMC
December 2018