Proof-of-Concept Rapid Diagnostic Test for Onchocerciasis: Exploring Peptide Biomarkers and the Use of Gold Nanoshells as Reporter Nanoparticles.
- Maria J Gonzalez-Moa,
- Bieke Van Dorst,
- Ole Lagatie,
- Ann Verheyen,
- Lieven Stuyver,
- Marco A Biamonte
ACS Infect Dis 2018 Mar 21. Epub 2018 Mar 21.
Drugs & Diagnostics for Tropical Diseases , 4898 Ronson Ct., Suite C , San Diego , California 92111 , United States.
Three O. volvulus immunogenic peptide sequences recently discovered by peptide microarray were adapted to a lateral flow assay (LFA). The LFA employs gold nanoshells as novel high-contrast reporter nanoparticles and detects a serological response against the 3 peptides, found in OvOC9384, OvOC198, and OvOC5528, respectively. Read More