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Arch Gynecol Obstet 2019 Feb 8. Epub 2019 Feb 8.

Department of Nursing, Chang Gung University of Science and Technology, No. 261, Wenhua 1st Rd., Guishan Dist., Taoyuan City, 33303, Taiwan, ROC.

Purpose: To examine temporal trends in stillbirth and its associated risk factors in Taiwan.

Methods: This was a population-based cohort study. Data were extracted from the Birth Certificate Application database. Read More

Arch Gynecol Obstet 2019 Feb 7. Epub 2019 Feb 7.

Rabin Medical Center, Helen Schneider Hospital for Women, 39 Zabotinski St, 4941492, Petach Tikva, Israel.

Objective: To compare pregnancy outcomes following induction of labor with prostaglandins versus extra-amniotic balloon catheter indicated for term isolated oligohydramnios.

Study Design: Retrospective cohort study of all women who underwent induction of labor due to term isolated oligohydramnios at a university affiliated medical center (2007-2016). The cohort was divided into two subgroups, according to induction method: vaginal prostaglandins E2 versus extra-amniotic balloon catheter. Read More

Case Rep Pediatr 2018 30;2018:4549060. Epub 2018 Dec 30.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Complications due to spontaneous septostomy of the dividing membrane in monochorionic diamniotic pregnancies are rarely described. Herein, we report the case of a preterm female neonate from a monochorionic diamniotic twin pregnancy delivered by caesarean section at 32 weeks of gestation. She was born with a broad band of a transparent membrane-like material firmly attached to her lower abdomen. Read More

J Matern Fetal Neonatal Med 2019 Jan 28:1-6. Epub 2019 Jan 28.

b Department of Biochemistry, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.

Objective: To investigate cord blood ischemia-modified albumin (IMA) levels in pregnancies with intrauterine growth restriction (IUGR) and to determine its association with abnormal fetal Doppler findings.

Methods: Umbilical cord IMA levels were assessed in 34 pregnant women with IUGR and 32 pregnancies with normal fetal development. Associations of IMA with abnormal umbilical artery Doppler findings, preeclampsia, and oligohydramnios were investigated. Read More

Prenat Diagn 2019 Jan 16. Epub 2019 Jan 16.

The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Objectives: To delineate the etiology and outcome of prenatally diagnosed isolated bilateral hyperechogenic kidneys (IBHK).

Study Design: Pregnancies with IBHK on prenatal ultrasound identified and followed by us between January 1, 2000 and January 1, 2015, were evaluated regarding the etiology and outcome by evaluation of family history, targeted AR-PKD and AD-PKD DNA analysis and microarray analysis, according to renal size and amniotic fluid volume.

Results: Of the 52 identified cases, there were 34 cases with enlarged kidneys, 16 with normal size kidneys and 2 with small kidneys. Read More

Turk Patoloji Derg 2019 Jan 11. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, Istanbul University, School of Medicine Istanbul, ISTANBUL, TURKEY.

Prune belly syndrome (PBS) is characterized by a classical triad of congenitally absent abdominal muscles, bilateral cryptorchidism, and a malformed urinary tract. Urorectal septum malformation sequence (URSM) is identified with the absence of urogenital and anal openings. This case report describes a 15-week-old female fetus with megacystis, ascites and oligohydramnios in a 19-year-old nulliparous woman. Read More

J Matern Fetal Neonatal Med 2019 Feb 3:1-6. Epub 2019 Feb 3.

a Department of Obstetrics and Gynecology , Fetal Medicine Unit , Santiago , Chile.

Objective: To describe the use of a self-retaining thermoplastic polyurethane wound retractor for the management of hysterotomy during prenatal repair of myelomeningocele.

Methods: The preliminary experience with 16 consecutive cases of open surgery for prenatal repair of myelomeningocele using a new technique is presented. Under general anesthesia, the gravid uterus was partially exteriorized through a low transverse abdominal incision and a high 3-4-cm midline vertical mini-hysterotomy was performed. Read More

Ultrasound Q 2018 Dec 28. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology, Erciyes University Faculty of Medicine.

The aims of the study were to compare the different estimation methods for the diagnosis of oligohydramnios and to determine concordance between estimated amniotic fluid volume (AFV) measured by ultrasonography and actual AFV measured directly. Another purpose was to investigate the effect of oligohydramnios on neonatal outcome. This study was done at a tertiary care center. Read More

Matern Health Neonatol Perinatol 2018 20;4:27. Epub 2018 Dec 20.

University Children's Hospital Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany.

Background: Oligohydramnios sequence can be caused by renal tubular dysgenesis (RTD), a rare condition resulting in pulmonary and renal morbidity. Besides typical features of Potter-sequence, the infants present with severe arterial hypotension and anuria as main symptoms. Establishing an adequate arterial blood pressure and sufficient renal perfusion is crucial for the survival of these infants. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Feb 13;233:120-126. Epub 2018 Dec 13.

Department of Urology, Shengjing Hospital, China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning 110004, China. Electronic address:

Objective: To explore the outcomes and prognostic factors associated with fetal megacystis (enlarged bladder).

Study Design: The MEDLINE and EMBASE databases were searched for studies reporting on outcomes of fetal megacystis. The outcomes observed were chromosomal abnormalities, associated structural anomalies, spontaneous resolution, and survival rates. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13672

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu.

Rationale: Sirenomelia is a very rare congenital malformation and characterized by fused lower extremities, oligohydramnios, renal agenesis, absent urinary tract and external genitalia, single umbilical artery, and imperforate anus. Ultrasonography is an optimal method for prenatal screening and diagnosis of sirenomelia. The incidence of sirenomelia in the twin pregnancy is extremely low. Read More

Orphanet J Rare Dis 2018 Dec 17;13(1):226. Epub 2018 Dec 17.

Department of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Chung-Shan North Road, Taipei, Taiwan.

Background: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disease characterized by the combination of glomerulopathy with early-onset nephrotic syndrome and microcephaly with central nervous system anomalies. Given its clinical heterogeneity, GAMOS is believed to be a genetically heterogenous group of disorders. Recently, it has been reported that mutations in KEOPS-encoding genes, including the OSGEP gene, were responsible for GAMOS. Read More

Urol Int 2018 Dec 12:1-3. Epub 2018 Dec 12.

Norton Children's Urology, Norton Healthcare, Louisville, Kentucky,

Cloacal anomalies (persistent cloaca) represent the most severe form of anorectal malformations in girls where the rectum, urethra, and vagina remain fused together inside the pelvis and drain into a single common perineal orifice. Infants with cloacal anomalies often succumb to poor lung development due to oligohydramnios. Cloacal anomaly in discordant monozygotic twins has rarely been reported in the literature. Read More

Obstet Gynecol 2019 Jan;133(1):129-136

Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, the Departments of Obstetrics and Gynecology and Pediatrics, Grow, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Department of Obstetrics, Leiden University Medical Center, Leiden, the Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Department of Obstetrics and Gynecology, Maxima Medical Center, Veldhoven, the Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, the Department of Neonatology, Emma Children's Hospital Academic Medical Center, Amsterdam, the Department of Obstetrics and Gynecology, Martini Hospital, Groningen, the Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, and the Department of Obstetrics and Gynecology and the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; and Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, Australia.

Objective: To assess the effectiveness of amnioinfusion in women with second-trimester preterm prelabor rupture of membranes.

Methods: We performed a nationwide, multicenter, open-label, randomized controlled trial, the PPROM: Expectant Management versus Induction of Labor-III (PPROMEXIL-III) trial, in women with singleton pregnancies and preterm prelabor rupture of membranes at 16 0/7 to 24 0/7 weeks of gestation with oligohydramnios (single deepest pocket less than 20 mm). Participants were allocated to transabdominal amnioinfusion or no intervention in a one-to-one ratio by a web-based system. Read More

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

J Matern Fetal Neonatal Med 2018 Nov 28:1-181. Epub 2018 Nov 28.

b Department of Obstetrics and Gynecology , Brigham and Women's Hospital , Harvard Medical School , Boston , USA.

Objective: The purpose of this study is to assess the incidence of oligohydramnios at term and evaluate whether mode of delivery in patients with oligohydramnios influences perinatal outcomes in China.

Methods: A cross sectional survey of all deliveries in 39 hospitals in China from 1 January to 31 December, 2011 was evaluated for mode of delivery and perinatal outcomes in women with oligohydramnios compared to those without known oligohydramnios after excluding preterm births, polyhydramnios, and oligohydramnios secondary to premature rupture of membranes.

Results: Oligohydramnios complicated 3954 (4. Read More

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

J Gynecol Obstet Hum Reprod 2019 Jan 19;48(1):61-64. Epub 2018 Nov 19.

Fetal Medicine unit, Université Claude Bernard, Lyon 1, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, 59 boulevard Pinel, 69500, Bron, Lyon, France. Electronic address:

We report prenatal imaging features of four cases of neonatal hemochromatosis due to an alloimmune disease. All cases exhibited intra uterine growth restriction (IUGR) without arguments for a vascular etiology, associated with oligohydramnios. Placental hydrops was present in 75% of cases. Read More

Cleft Palate Craniofac J 2018 Nov 19:1055665618811503. Epub 2018 Nov 19.

2 Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA, USA.

Objective:: The purpose of this study was to determine whether gestational amniotic fluid level abnormalities were associated with postnatal syndromic status in a series of patients with Robin sequence (RS).

Design:: Retrospective study of participants with RS at Boston Children's Hospital from 1967 to 2017. Participants were divided into syndromic and nonsyndromic groups. Read More

Obstet Gynecol 2018 Dec;132(6):1358-1367

Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, and the Center for Clinical Research and Evidence-Based Medicine, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas.

Objective: Among uncomplicated pregnancies, serial third-trimester ultrasound examinations identified significantly more cases with a composite of fetal growth or amniotic fluid abnormalities (27%) than did routine fundal height measurements (8%).

Methods: Women without complications between 24 0/7 and 30 6/7 weeks of gestation were randomized (NCT0270299) to either routine care (control arm) or ultrasound examination every 4 weeks (intervention arm). The primary outcome was a composite of abnormalities of fluid volume and growth: oligohydramnios or polyhydramnios; fetal growth restriction; or large for gestational age. Read More

Eur J Radiol 2018 Nov 24;108:128-132. Epub 2018 Sep 24.

Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. Electronic address:

We sought to evaluate the diagnostic value of foetal magnetic resonance imaging (MRI) for multicystic dysplastic kidney (MCDK) disease. We retrospectively identified 55 foetuses with MCDK diagnosed (51 unilateral; 4 bilateral) by foetal MRI. We analysed the anatomical findings by prenatal MRI and compared them with the prenatal ultrasound (US) and postnatal findings. Read More

J Matern Fetal Neonatal Med 2019 Jan 22:1-5. Epub 2019 Jan 22.

a Pondicherry Institute of Medical Sciences, Obstetrics & Gynaecology , Pondicherry , India.

Objective: To evaluate the maternal and perinatal outcomes of labor induction in women at term with oligohydramnios.

Methods: A retrospective cohort of women with a singleton pregnancy, who had oligohydramnios at or beyond term (37-42 weeks) and underwent induction of labor for oligohydramnios were studied. Antenatally diagnosed fetal anomalies and intrauterine fetal demise were excluded. Read More

JNMA J Nepal Med Assoc 2018 Mar-Apr;56(211):674-677

Department of Obstetrics and Gynaecology, KIST Medical College and Teaching Hospital, Lalitpur, Nepal.

Introduction: This study was done to find out the incidence of malpresentation among all deliveries with various types of Malpresentations, its mode of delivery , maternal and fetal predisposing factors with outcome.

Methods: This was a cross sectional descriptive study done at KIST Medical College and Teaching Hospital. Review cases of women admitted in labor after 22 weeks with malpresentation was done. Read More

Am J Perinatol 2018 Oct 29. Epub 2018 Oct 29.

Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri.

Objective:  To estimate the effect of oligohydramnios on fetal heart rate (FHR) patterns in patients undergoing induction of labor (IOL) at term.

Study Design:  Secondary analysis of a prospective cohort study of consecutive term, singleton deliveries from 2010 to 2015. We included all patients who underwent IOL. Read More

Nephron 2019 25;141(1):50-60. Epub 2018 Oct 25.

Early and severe forms of polycystic kidney disease (PKD) do already manifest during childhood or adolescence. They are characterized by enlarged kidneys and diminished renal function that prenatally may result in Potter's oligohydramnios sequence. Genetically, various defects can mimic this phenotype. Read More

J Craniofac Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, Duke University Medical Center, Durham, NC.

Background: Certain intrauterine risk factors are known to increase the risk of premature cranial suture fusion and may cause complications during birth. Some of these risk factors may be modifiable. Therefore, the authors sought to characterize the institutional patterns of prenatal risk factors and perinatal complications in nonsyndromic craniosynostosis patients compared to normal births from the surrounding area to identify areas for possible intervention or prevention. Read More

Arch Gynecol Obstet 2019 Jan 9;299(1):79-88. Epub 2018 Oct 9.

Division of Perinatology, Department of Obstetrics and Gynecology, Medical Faculty, Hacettepe University, Sıhhiye, Ankara, Turkey.

Purpose: To evaluate the clinical characteristics, obstetric/neonatal outcomes, and pregnancy complications of pregnant women with Takayasu arteritis (TA).

Methods: We retrospectively evaluated the data of 22 pregnancies of 11 patients with TA between January 1 2000, and December 31 2017. Patient characteristics, severity of disease, obstetric outcomes, pregnancy complications, mode of delivery, and neonatal outcomes were evaluated. Read More

Fetal Diagn Ther 2018 Oct 9:1-6. Epub 2018 Oct 9.

Center for Fetal Therapy, Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Introduction: To evaluate if the volume-corrected renal artery pulsatility index (vcRA-PI) is more closely related to the amniotic fluid level than the uncorrected or the gestational age (GA)-adjusted RA-PI.

Methods: RA-PI and kidney volume were measured in low- and high-risk pregnancies at 17-38 weeks. Fetal anomalies associated with nonrenal causes of abnormal amniotic fluid volume were excluded. Read More

JBI Database System Rev Implement Rep 2019 Feb;17(2):170-208

Department of Midwifery and Therapeutic Sciences, University College Copenhagen, Copenhagen, Denmark.

Objective: The objective of this review was to identify, assess and synthesize the best available evidence on the effects of induction prior to post-term on the mother and fetus. Maternal and fetal outcomes after routine labor induction in low-risk pregnancies at 41+0 to 41+6 gestational weeks (prior to post-term) were compared to routine labor induction at 42+0 to 42+6 gestational weeks (post-term).

Introduction: Induction of labor when a pregnancy exceeds 14 days past the estimated due date has long been used as an intervention to prevent adverse fetal and maternal outcomes. Read More

Case Rep Womens Health 2018 Oct 26;20:e00081. Epub 2018 Sep 26.

Department of Endocrinology and Diabetes, "Alexandra" Hospital, Athens, Greece.

A 33-year-old Caucasian woman was referred at 24 + 3 weeks of gestation due to fetal tachycardia and hydrops. She had an uncomplicated pregnancy 16 years previously and was on levothyroxine after total thyroidectomy for Graves' disease 6 years previously, when she developed moderate exophthalmos. Laboratory evaluation revealed appropriate thyroid function for this time of gestation: thyroid stimulating hormone (TSH) 1. Read More

J Family Reprod Health 2017 Dec;11(4):225-227

Department of Obstetrics and Gynecology, PGIMS, Rohtak, India.

To report a case of Successful Pregnancy Outcome in Recurrent Ovarian Cancer in a 26 year Old. A 26 years old primigravida presented in antenatal clinic at 23 weeks of pregnancy with recurrence of ovarian cancer of mucinous type. Following refusal of surgical management, two courses of single dose carboplatin was administered. Read More

J Clin Med 2018 Oct 4;7(10). Epub 2018 Oct 4.

Department of Medicine, Division of Nephrology, Sunnybrook Science Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada.

We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolution of fetal renal echogenicity. The newborn was noted to have transient renal dysfunction and proteinuria, resolving by 6 weeks postpartum. Read More

J Genet 2018 Sep;97(4):925-930

Pediatric Orthopedic Surgery Department, King Abdullah Specialized Children Hospital (KASCH), P.O. Box 22490, Riyadh 11426, Saudi Arabia.

Developmental dysplasia of the hip (DDH) is a congenital condition characterized by abnormality in acetabulum size and/or shape. The incidence rate of DDH differs between different populations with risk factors including positive family history, breech presentation, sex, firstborn status, side of the hip, mode of delivery and oligohydramnios. It is recognized that DDH has a genetic component that exhibit autosomal dominant patterns. Read More

Ultrasound Obstet Gynecol 2018 Sep 25. Epub 2018 Sep 25.

Maternal Fetal Medicine, Sunshine Hospital, Western Health, Melbourne, Australia.

We present the case of a 20-year-old primiparous woman with an ultrasound at 30 weeks demonstrating a male fetus with symmetrical intrauterine growth restriction (IUGR) (head circumference <1%, abdominal circumference 6%, femur <1%) and oligohydramnios (AFI 8.6cm, <5 centile). This article is protected by copyright. Read More

AJP Rep 2018 Jul 14;8(3):e180-e183. Epub 2018 Sep 14.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.

Prelabor rupture of the membranes (PROM) near the limit of viability is associated with significant risks for both mother and fetus. Preterm labor, intra-amniotic infection, and placental abruption are the immediate risks to the pregnancy; however, the fetus incurs additional risks related to the sequela of persistent oligohydramnios. Transabdominal intra-amniotic infusions have been studied. Read More

J Obstet Gynaecol 2019 Jan 22;39(1):49-53. Epub 2018 Sep 22.

a Department of Fetal-Maternal Medicine , Nagara Medical Center , Gifu , Japan.

We report prophylactic amnioinfusion (AI) for variable decelerations in umbilical cord compression without oligohydramnios as an early sign of deterioration. We performed a transabdominal AI in cases without oligohydramnios using the ultrasonography findings of umbilical cord compression (i.e. Read More

J Pediatr Urol 2018 Aug 8;14(4):332.e1-332.e6. Epub 2018 Aug 8.

Department of Urology, Division of Pediatric Urology, UW School of Medicine and Public Health, 3rd Floor MFCB, 1685 Highland Ave, Madison, WI 53705, USA. Electronic address:

Introduction: Management of severe antenatally detected oligohydramnios with and without obstruction is improving with the result that more fetuses are surviving with early renal failure. Significant advances have occurred in all specialties involved in the management of these patients. All these specialties working together have resulted in the survival of more patients born with renal failure. Read More

Acta Med Litu 2018 ;25(2):95-100

Clinic of Obstetrics and Gynaecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Background: A congenital cystic adenomatoid malformation (CCAM) is a foetal pulmonary development abnormality caused by airway dysgenesis that is characterized by cystic or adenomatous lesions in the terminal bronchioles. The size of the mass, the degree of the mediastinal shift, and the presence of hydrops and polyhydramnios can all affect the severity of a case. Treatment can be initiated at early stages by applying prenatal and postnatal methods. Read More

Early Hum Dev 2018 12 8;127:1-5. Epub 2018 Sep 8.

Imperial College Healthcare NHS Trust, Neonatal Unit, London, UK.

Background: Although inhaled nitric oxide (iNO) therapy in term infants with pulmonary hypertension (PHT) has demonstrated definite benefit, the use of iNO in preterm infants remains inconclusive.

Aims: To evaluate the impact of iNO treatment in premature infants with acute PHT.

Study Design: Retrospective cohort. Read More

Fetal Pediatr Pathol 2018 Aug 6;37(4):254-262. Epub 2018 Sep 6.

a Department of Obstetrics & Gynaecology , PGIMER Chandigarh , Chandigarh , India.

Objective: To evaluate the fetal anomalies in all the patients who underwent elective termination of pregnancy for fetal anomalies (ETOPFA) before 20 weeks of gestation and to compare prenatal diagnosis with final diagnosis made after autopsy.

Methodology: Prospective study done in a tertiary care hospital in India over a period of two years which include 252 women who underwent ETOPFA. The prenatal diagnosis was compared with final diagnosis made after autopsy. Read More

Cureus 2018 Jul 1;10(7):e2904. Epub 2018 Jul 1.

MS4/Ross University School of Medicine, California Hospital Medical Center, Los Angeles, USA.

The differential diagnosis of third trimester bleeding can range from placenta abruptia to placenta previa to uterine rupture and the placenta accreta spectrum (PAS). However, patients with risk factors such as multiple cesarean sections (c-sections), advanced maternal age (AMA), grand multiparity, and single-layer uterine closure are at greater risk of developing these complications earlier than we would traditionally expect. This case recounts a 38-year-old gravida 6 preterm 3 term 1 abortus 1 live 4 (G6P3114) at 23 weeks and five days gestational age (GA) with a past medical history of preterm pregnancy, pre-eclampsia, chronic abruptia, three previous c-sections, and low-lying placenta who presented to the emergency department (ED) with vaginal bleeding. Read More

Malays J Pathol 2018 Aug;40(2):149-152

Ampang Hospital, Department of Haematology, Malaysia.

Introduction: Non-transfusion dependent thalassaemia (NTDT) is a term used for thalassaemia patients who do not require lifelong regular transfusions for survival. Pregnancy in these women, whether spontaneous or through assisted reproductive technology, represents a challenge for the physician.

Materials And Methods: The maternal and foetal outcomes of patients with NTDT followed up in a tertiary haematology centre over 6 months period were studied. Read More

Women Birth 2018 Aug 24. Epub 2018 Aug 24.

Department of Epidemiology, University of Washington, Seattle, WA, United States.

Background: Breech presentation affects approximately 3% of women with singleton pregnancies. External cephalic version is a manual procedure that reorients a foetus to cephalic position in preparation for birth, reducing indications for caesarean birth. However, unsuccessful attempts are associated with some adverse health outcomes. Read More

J Nippon Med Sch 2018 ;85(3):191-193

Department of Internal Medicine, Chonnam National University Medical School.

We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3. Read More

APMIS 2018 Jul;126(7):626-637

Department of Pathology, Cork University Hospital, Cork, Ireland.

Twin placentas are frequently received in pathology laboratories for evaluation of chorionicity and because twin pregnancies have higher rates of pregnancy complications. In addition to pathologies common in singleton pregnancies, twin pregnancies have increased frequencies of complications such as preterm birth and velamentous cord insertions and also are affected by complications unique to multiple pregnancies that are mediated by vascular connections between the placental territories of certain types of twins. This article aims to provide an approach to examination of the twin placenta for practicing pathologists or those interested in placental pathology while outlining the key characteristics of twin complications as seen in the placenta. Read More

Anticancer Drugs 2018 Sep;29(8):810-813

Department of Medical Oncology, Dr Ersin Arslan Training and Research Hospital, Gaziantep, Turkey.

Trastuzumab and pertuzumab are monoclonal antibodies used for the treatment of breast cancer. Until now, there have been no reports on the use of pertuzumab during pregnancy and on its potential effects on the fetus. Herein, we present a breast cancer patient who received trastuzumab and pertuzumab treatment during the first 20 weeks of pregnancy. Read More

J Pediatr Urol 2018 Aug 24;14(4):320.e1-320.e6. Epub 2018 Jul 24.

Division of Pediatric Urology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL, USA.

Background: Vesicoamniotic shunting (VAS) and other bladder drainage techniques for fetal lower urinary tract obstruction (LUTO) have been proven to ameliorate pulmonary hypoplasia and increase survival in patients with an initial poor prognosis. Currently there are limited prognostic tools available during gestation to evaluate and predict postnatal renal function.

Objective: The aim was to describe the prenatal growth of the renal parenchymal area (RPA) in patients with LUTO and determine its application as a predictor of renal function at one year of life. Read More

J Matern Fetal Neonatal Med 2018 Aug 5:1-11. Epub 2018 Aug 5.

a University of Nevada School of Medicine - Las Vegas Campus , Las Vegas , Nevada , United States of America.

Objective: Daily opioid dependence for maternal pain management, methadone maintenance, or buprenorphine/naloxone therapy is an increasing trend in modern obstetrics. Opioids may produce depressive effects on fetal neurobehavioral status and thus on fetal heart rate patterns. Our primary objective was to describe the current methods utilized in antenatal monitoring of the daily opioid exposed fetus; and to describe interventions based upon monitoring which precipitated a recommendation for delivery. Read More

Eur J Med Genet 2018 Jul 31. Epub 2018 Jul 31.

Division of Nephrology, Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

Renal tubular dysgenesis (RTD) is a developmental abnormality of the nephron characterized by fetal anuria, oligohydramnios, and severe postnatal hypotension. Genetic forms have an autosomal recessive inheritance and are caused by mutations in genes encoding key components of the renin-angiotensin pathway. We report three patients from two unrelated families with RTD due to pathogenic variants of the angiotensin-converting enzyme (ACE) gene, in whom RTD was associated with microcolon. Read More

J Paediatr Child Health 2019 Feb 1;55(2):168-174. Epub 2018 Aug 1.

Department of Orthopaedics and Traumatology, Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey.

Aim: The aim of the present study was to examine if there were gender differences in risk factors in 4415 infants who were evaluated through a physical examination and hip ultrasonography (USG).

Methods: Physical examination of the hip and hip USG were performed on 4415 infants by the same paediatric orthopaedics specialist. Barlow and Ortolani tests were performed together with the evaluation for the limitation of abduction. Read More