Search Our Scientific Publications & Authors

Rev Med Inst Mex Seguro Soc 2022 Mar 1;60(2):116-128. Epub 2022 Mar 1.

Instituto Mexicano del Seguro Social, Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", División de Obstetricia. Ciudad de México, México.

Background: COVID-19 disease is the leading cause of maternal death in Mexico. The data published to date indicate that pregnancy favors severe forms of the disease.

Objective: To describe the clinical, obstetric and perinatal characteristics of pregnant women with COVID-19 disease treated at the UMAE "Luis Castelazo Ayala" of the Instituto Mexicano del Seguro Social. Read More

Sensors (Basel) 2022 Jun 17;22(12). Epub 2022 Jun 17.

Department of Computer Science, College of Computer Science and Information Technology, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

A fetal ultrasound (US) is a technique to examine a baby's maturity and development. US examinations have varying purposes throughout pregnancy. Consequently, in the second and third trimester, US tests are performed for the assessment of Amniotic Fluid Volume (AFV), a key indicator of fetal health. Read More

Clin Genet 2022 Jun 14. Epub 2022 Jun 14.

Department of Medical Genetics, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Crisponi / cold-induced sweating syndrome (CS/CISS) is a rare autosomal recessive disorder characterized by episodic hyperthermia, arthrogryposis, impaired feeding ability, and respiratory distress. The classic CS/CISS is mainly associated with CRLF1 and, rarely, CLCF1. PERCHING syndrome, previously known as CS/CISS type-3 associated with biallelic pathogenic variants in KLHL7, is notable for its few overlapping manifestations. Read More

Cell Tissue Res 2022 Jun 8. Epub 2022 Jun 8.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 325027, Wenzhou, China.

The mechanism of idiopathic oligohydramnios is still uncertain, and there is no effective and targeted treatment for it. Placental aquaporins (AQPs) were associated with idiopathic oligohydramnios. This study aimed to investigate the effect of tanshinone IIA on amniotic fluid volume (AFV) and its underlying molecular mechanisms related to placental AQPs (AQP1, AQP3, AQP8, AQP9). Read More

Eur J Obstet Gynecol Reprod Biol 2022 Jul 31;274:175-181. Epub 2022 May 31.

National Laboratory for Human Reproduction, University of Pécs, Pécs, Hungary; Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary; Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary; Hungarian Academy of Sciences - University of Pécs Human Reproduction Scientific Research Group, University of Pécs, Pécs, Hungary.

During normal pregnancy, blood volume increases by nearly two liters. Distinctively, the absence coupled with the extreme extent regarding the volume expansion, are likely accompanied with pathological conditions. Undoubtedly, preeclampsia, defined as the appearance of hypertension and organ deficiency, such as proteinuria during the second half of pregnancy, is not a homogenous disease. Read More

Ann Med Surg (Lond) 2022 May 13;77:103626. Epub 2022 Apr 13.

Cardiology Department, Mogadishu Somali Turkey, Recep Tayyip Erdogan Training and Research Hospital, Somalia.

Introduction: and importance: Sirenomelia is a life-threatening condition caused by a rare developmental abnormality. According to the research, the incidence of sirenomelia is estimated to be between 1.5 and 4. Read More

Urology 2022 May 24. Epub 2022 May 24.

Department of Pediatric Urology, Jackson Memorial Hospital, Miami, FL; Department of Pediatric Urology, Nicklaus Children's Hospital, Miami, FL; Department of Urology, University of Miami Medical School, Miami, FL. Electronic address:

Vesicoamniotic shunting (VAS) is one of the most common surgical options in selected cases of severe fetal obstructive uropathy. Abdominal evisceration secondary to VAS has been reported in only eight cases. A pregnant woman underwent VAS due to lower urinary tract obstruction with severe oligohydramnios. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2022 May;39(5):510-513

Ningbo University School of Medicine, Ningbo, Zhejiang 315211, China.

Objective: To explore the clinical features and genomic abnorm ality of a fetus enlarged multicystic dysplastic kidneys with oligohydramnios caused by NPHP3 gene mutation.

Methods: The fetuse was found to have multicystic dysplastic kidneys with oligohydramnios upon ultrasonography during the second trimester. Following induced abortion, fetal tissue was collected for the extraction of DNA, chromosomal microarray analysis (CMA) and whole exome sequencing (WES). Read More

Taiwan J Obstet Gynecol 2022 May;61(3):521-524

Division of Genetics, Endocrinology and Metabolism, Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Objective: To demonstrate the picture of a woman who had three times of pregnancies but fetuses were complicated with Fraser syndrome, a rare genetic disorder with multiple congenital anomalies.

Case Report: Here are three complicated pregnancies with predominant features of severe oligohydramnios and other variable intrafamilial presentations. We made a definite diagnosis, Fraser syndrome, with the assistance of whole exome sequencing (WES) via umbilical blood of the second and third fetus. Read More

Int J Environ Res Public Health 2022 04 23;19(9). Epub 2022 Apr 23.

Center of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-813 Warsaw, Poland.

Placental abruption (PA) is a separation of the placenta from the uterine wall occurring with the fetus still present in the uterine cavity. It contributes to numerous neonatal and maternal complications, increasing morbidity and mortality. We conducted a retrospective study at a tertiary perinatal care center, which included 2210 cases of labor that took place in 2015 with a PA occurrence of 0. Read More

Andes Pediatr 2022 Feb 28;93(1):78-85. Epub 2022 Mar 28.

Facultad de Medicina, Universidad de Chile, Santiago, Chile.

The presence of fetal megacystis in a renal ultrasound may suggest a mechanical or functional bladder outlet obstruction, an uncommon condition with a poor outcome.

Objective: To determine prog nostic factors in fetuses with prenatal diagnosis of megacystis.

Patients And Method: Retrospective study carried out between 2003 and 2018 in the Orient Perinatal Reference Center (CERPO), Uni versity of Chile. Read More

Iran J Child Neurol 2022 14;16(2):85-92. Epub 2022 Mar 14.

Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Objectives: Deformation of the skull by external forces in the absence of synostosis has been defined as positional plagiocephaly (PP). The aim of this investigation was to determine the risk factors of PP in healthy Iranian infants.

Materials & Methods: This case-control study was performed on 300 healthy Iranian infants aged 8-12 weeks who were referred to the pediatric neurology clinic at Shahid Beheshti Hospital of Kashan. Read More

Ann Med Surg (Lond) 2022 Apr 29;76:103533. Epub 2022 Mar 29.

Department of Pediatric, Mogadishu Somalia Turkish Training and Research Hospital, Somalia.

Introduction: and Importance: Sirenomelia, which called sirenomelia sequences, is a very rare congenital malformation. It is characterized by complete or incomplete fused lower extremities, renal agenesis, oligohydramnios, absent urinary tract and external genitalia, single umbilical arteries, imperforate anus, etc.We are reporting a case of mermaid syndrome, a twin pregnancy in which one was healthy and the other was identified to have characteristic features of sirenomelia at the time of examination. Read More

Best Pract Res Clin Obstet Gynaecol 2022 Mar 31. Epub 2022 Mar 31.

Department of Maternal-Fetal Medicine, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Jalisco, Mexico.

Up to 20% of monochorionic diamniotic twin pregnancies can be complicated with twin-to-twin transfusion syndrome (TTTS). This complication is diagnosed by ultrasound demonstrating amniotic fluid discordance between both amniotic sacs, with polyhydramnios in the recipient's sac and oligohydramnios in the donor's, secondary to an imbalance in blood volume exchange between twins. Ultrasound evaluation of the amniotic fluid volume, bladder filling, and assessment of fetal Doppler parameters provide the basis for classification of TTTS, allowing severity assessment. Read More

Pediatr Nephrol 2022 Apr 25. Epub 2022 Apr 25.

Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

Background: The aim of the study was to determine the prevalence of congenital anomalies of the kidney and urinary tract (CAKUT) in the neonatal intensive care unit (NICU) and to evaluate risk factors associated with worse outcomes. We hypothesized that infants with CAKUT with extra-renal manifestations have higher mortality.

Methods: This is a cohort study of all inborn infants who were diagnosed with any form of CAKUT discharged from NICUs managed by the Pediatrix Medical Group from 1997 to 2018. Read More

Am J Obstet Gynecol 2022 Apr 20. Epub 2022 Apr 20.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME.

Second- and third-trimester obstetrical ultrasound examinations include an amniotic fluid volume assessment. Professional organizations' clinical guidance recommends using semiquantitative techniques, such as the single deepest vertical pocket or amniotic fluid index, for this purpose. The single deepest vertical pocket is described as the preferred method of assessing amniotic fluid volume based on fewer oligohydramnios diagnoses and labor inductions with no demonstrable difference in pregnancy outcomes compared with the amniotic fluid index. Read More

Eur J Obstet Gynecol Reprod Biol 2022 05 8;272:255-256. Epub 2022 Apr 8.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

BJOG 2022 Apr 12. Epub 2022 Apr 12.

The Fetal Medicine Centre, Birmingham Women's and Children's Foundation Trust, Edgbaston, Birmingham, UK.

Aim: To construct evidence-based algorithms for the assessment and management of common amniotic fluid abnormalities detected during labour.

Population: Low-risk singleton, term pregnant women in labour.

Setting: Birth facilities in low- and middle-income countries. Read More

J Matern Fetal Neonatal Med 2022 Apr 10:1-7. Epub 2022 Apr 10.

Fetal Medicine Research Center, BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Universitat de Barcelona, Barcelona, Catalonia, Spain.

Introduction: Obstructive ureterocele is an intravesical cystic dilation of the distal end of the ureter associated with anhidramnios and dilation of both renal pelvises.

Methods: This is a case-series of prenatally diagnosed ureterocele. Cases were selected at a third level reference hospital in Monterrey Mexico between 2010 and 2018. Read More

Cureus 2022 Mar 1;14(3):e22735. Epub 2022 Mar 1.

Rheumatology, Einstein Medical Center Philadelphia, Philadelphia, USA.

Corticosteroid therapy is a known risk factor for osteonecrosis, more commonly with chronic use and high cumulative dose. Osteonecrosis (avascular necrosis) has been described in pregnancy involving primarily the femoral head. To our knowledge, only rare cases of femoral meta diaphysis or knee osteonecrosis in pregnancy have been documented in the literature. Read More

J Perinat Med 2022 Apr 4. Epub 2022 Apr 4.

Subdirección de Servicios Auxiliares de Diagnóstico, Instituto Nacional de Perinatología, Ciudad de México, México.

Objectives: To analyze the role of viral infections as etiology of stillbirths in Mexico and their epidemiological impact in the context of the global Every Newborn Initiative.

Methods: A comprehensive literature search was performed in electronic databases related to stillbirth and viral infections published prior to January 19th 2021. Stillbirths records and causes from National Mexican databases, during 2008-2019 period were also computed. Read More

Cureus 2022 Feb 18;14(2):e22360. Epub 2022 Feb 18.

Obstetrics and Gynecology, Tata Main Hospital, Jamshedpur, IND.

Background The ongoing coronavirus 2019 (COVID-19) pandemic is the most devastating health care crisis of our times. Pregnant women with COVID-19 infection belong to a vulnerable group with concerns about the effect of the disease on maternal and neonatal health. As we are dealing with a new disease, we must study the changing trend of disease presentation, diagnosis, and treatment to successfully manage such pregnancies. Read More

Front Endocrinol (Lausanne) 2022 15;13:832665. Epub 2022 Mar 15.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: The purpose of this study was to clarify the influence of the vanishing twin (VT) on the perinatal outcomes in the surviving singleton and further identify the susceptible window.

Study Design: Retrospective cohort study.

Methods: A total of 636 survivors of a vanished co-twin and 11,148 singleton controls were enrolled. Read More

Taiwan J Obstet Gynecol 2022 Mar;61(2):277-281

Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507 Japan.

Objective: Although cyclooxygenase inhibitors effectively suppress uterine contraction, constriction of the fetal ductus arteriosus (DA) and oligohydramnios are major concerns. Celecoxib, a selective cyclooxygenase 2 inhibitor, is a potential potent tocolytic agent, but there are no studies that have evaluated the beneficial or adverse effects of celecoxib use on fetuses for more than 48 hours in pregnant women. We therefore aimed to evaluate the effect of middle-long-term celecoxib administration on the fetus during the second trimester of pregnancy, particularly in terms of fetal DA and amniotic fluid volume. Read More

Taiwan J Obstet Gynecol 2022 Mar;61(2):243-248

Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Shogoinkawahara-cho, 54, Sakyo-ku, Kyoto City, Kyoto, 606-8507, Japan.

Objective: To investigate the factors that stratify high-risk cases among subchorionic hematomas (SCHs) patients with persistent vaginal bleeding in early pregnancy.

Materials And Methods: A total of 56 patients who required hospitalization for SCH with vaginal bleeding in early pregnancy were classified into two groups: 1) no hematoma by ultrasonography when vaginal bleeding occurred, and then hematoma was observed by ultrasonography "bleeding to hematoma (BH group, n = 15)" and 2) no vaginal bleeding when hematoma was observed by routine ultrasonography, and then vaginal bleeding occurred later "hematoma to bleeding (HB group, n = 41)". Retrospective cohort study was performed and maternal and neonatal outcomes were evaluated. Read More

Cureus 2022 Feb 15;14(2):e22223. Epub 2022 Feb 15.

Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, IND.

Tropical diseases such as malaria, dengue, intestinal helminths, schistosomiasis, leishmaniasis, and filariasis have an essential influence on the reproductive health of patients. Various cases of pregnancy loss in unexplained circumstances are a result of underdiagnosed tropical diseases. Term pregnancy complicated by tropical diseases is a challenge for the treating clinicians as these infections tend to mimic HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelets) syndrome and increase the chances of perinatal complications and maternal mortality. Read More

Clin Case Rep 2022 Mar 16;10(3):e05605. Epub 2022 Mar 16.

Obstetrics and Gynecology Department Baharloo Hospital Tehran University of Medical Sciences Tehran Iran.

We present a case of giant chorioangioma at 18 weeks of gestation leading to fetal hypertrophic cardiomyopathy without other evidences of fetal volume overload and late-onset isolated proteinuria. Oligohydramnios developed at term and placental insufficiency was confirmed on histopathological examination and a nonanemic nonthrombocytopenic normal weight healthy baby was delivered. Read More

J Family Med Prim Care 2022 Jan 31;11(1):350-352. Epub 2022 Jan 31.

Department of Obstetrics and Gynaecology, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Women with schizophrenia have a high risk for symptom exacerbation or relapse during pregnancy and thereafter. Relapses are more frequent when antipsychotics are discontinued. Continuation of antipsychotic during pregnancy has become common and olanzapine is commonly prescribed antipsychotic. Read More

Exp Physiol 2022 05 3;107(5):508-514. Epub 2022 Apr 3.

Department of Obstetrics and Gynaecology, Shiga University of Medical Science Hospital, Otsu, Japan.

New Findings: What is the central question of this study? The physiological response to sacral neuromodulation by pregnant women and foetuses has not been previously explored. What is the main finding and its importance? Sacral surface electrical stimulation had no adverse effect on pregnant women and foetuses at least 36 weeks of gestation. It may cause uterine relaxation resulting from decreased uterine artery pulsatility index and increased umbilical venous flow volume and thereby improve utero-placental perfusion and improve lower back pain. Read More

Mol Genet Genomic Med 2022 05 14;10(5):e1920. Epub 2022 Mar 14.

Department of Medical Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Background: Autosomal-recessive renal tubular dysgenesis (AR-RTD) is a rare genetic disorder caused by defects in the renin-angiotensin system that manifests as fetal anuria leading to oligohydramnios and Potter sequence. Although the most common outcome is neonatal death from renal failure, pulmonary hypoplasia, and/or refractory arterial hypotension; several cases have been reported that describe survival past the neonatal period.

Methods: Herein, we report the first family with biallelic ACE variants and more than one affected child surviving past the neonatal period, as well as provide a review of the previously reported 18 cases with better outcomes. Read More