4,638 results match your criteria Oligodendroglioma


Molecular profile of tumors with oligodendroglial morphology: Clinical relevance.

Neurol India 2018 Nov-Dec;66(6):1726-1731

Department of Radiotherapy, Christian Medical College, Vellore, Tamil Nadu, India.

Background: The plethora of biomarkers available for the diagnosis and prognostication of gliomas has refined the classification of gliomas. The new World Health Organization (WHO) 2016 classification integrates the phenotypic and genotyping features for a more robust diagnosis.

Materials And Methods: Fifty gliomas with oligodendroglial morphology according to the WHO 2007 classification were analyzed for isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations by polymerase chain reaction, 1p/19q status by fluorescent in situ hybridization (FISH), and IDH1 and X-linked alpha-thalassemia retardation (ATRX) expression by immunohistochemistry. Read More

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December 2018

Tumour-to-Tumour Metastasis Phenomenon: Metastatic Prostatic Adenocarcinoma within an Anaplastic Oligodendroglioma in the Brain of a Dog.

J Comp Pathol 2018 Nov 29;165:62-66. Epub 2018 Oct 29.

Department of Animal Medicine and Surgery, Veterinary Faculty, Cerdanyola del Vallès, Spain; Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

A 10-year-old entire male French bulldog was presented following clusters of generalized tonic-clonic epileptic seizures. Neurolocalization was consistent with a lesion in the left forebrain. Magnetic resonance imaging of the brain revealed a large, ill-defined, intra-axial, space-occupying lesion at the level of the left temporal and parietal lobes, causing marked compression of the adjacent parenchyma. Read More

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November 2018

Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.

J Neurooncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurological Surgery, University of California, San Francisco, CA, USA.

Purpose: WHO grade II gliomas are uncommon in patients over the age of 60, and there is a lack in consensus regarding their management. We present molecular tumor characteristics as well as clinical outcomes in patients over the age of 60 undergoing surgical resection of a WHO grade II glioma.

Methods: After receiving IRB approval, patients were identified through the UCSF Brain Tumor Center. Read More

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November 2018

Evidence for Improving Outcome Through Extent of Resection.

Neurosurg Clin N Am 2019 Jan 1;30(1):85-93. Epub 2018 Nov 1.

Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143-0112, USA.

Surgical resection plays a central role in the management of gliomas however many tumors are within areas resulting in sensorimotor and cognitive consequences. This article reviews the evidence in support of extent of resection to improve survival, symptom management, and time to malignant transformation in low-grade gliomas. The authors summarize the evolving literature regarding the role of maximal safe resection in light of WHO subclassification of low-grade gliomas. Read More

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January 2019
14 Reads

Alterations in the Brain Microenvironment in Diffusely Infiltrating Low-Grade Glioma.

Neurosurg Clin N Am 2019 Jan 1;30(1):27-34. Epub 2018 Nov 1.

Department of Pathology and Cell Biology, Columbia University, Columbia University Medical Center, Irving Cancer Research Center, Room 1002, 1130 St Nicholas Avenue, New York, NY 10032, USA. Electronic address:

Glioma cells diffusely infiltrate the surrounding brain tissue where they intermingle with nonneoplastic brain cells, including astrocytes, microglia, oligodendrocytes and neurons. The infiltrative margins of glioma represent the structural and functional interface between neoplastic and nonneoplastic brain tissue that underlies neurologic alterations associated with glioma, including epilepsy and neurologic deficits. Technological advancements in molecular analysis, including single cell sequencing, now allow us to assess alterations in specific cell types in the brain tumor microenvironment, which can enhance the development of novel therapies that target glioma growth and glioma-induced neurologic symptoms. Read More

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January 2019

Molecular Pathogenesis of Low-Grade Glioma.

Neurosurg Clin N Am 2019 Jan;30(1):17-25

Department of Neurosurgery, Kimmel Center for Stem Cell Biology, Laura and Isaac Perlmutter Cancer Center, Neuroscience Institute, Brain Tumor Center, NYU School of Medicine, 530 First Avenue, Skirball 8R, New York, NY 10016, USA. Electronic address:

Advances in genome sequencing have elucidated the genetics of low-grade glioma. Available evidence indicates a neomorphic mutation in isocitrate dehydrogenase (IDH) initiates gliomagenesis. Mutant IDH produces the oncometabolite 2-hydroxyglutarate, which inhibits enzymes that demethylate genomic DNA and histones. Read More

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January 2019
6 Reads

Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system.

J Neurooncol 2018 Nov 22. Epub 2018 Nov 22.

Department of Neurosurgery, Medical Center, Freiburg, Germany.

Purpose: According to the 2016 WHO classification lower-grade gliomas consist of three groups: IDH-mutated and 1p/19q co-deleted, IDH-mutated and IDH-wildtype tumors. The aim of this study was to evaluate the impact of surgical therapy for lower-grade gliomas with a particular focus on the molecular subgroups.

Methods: This is a bi-centric retrospective analysis including 299 patients, who underwent treatment for lower-grade glioma between 1990 and 2016. Read More

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November 2018
2 Reads

MRI based texture analysis to classify low grade gliomas into astrocytoma and 1p/19q codeleted oligodendroglioma.

Magn Reson Imaging 2018 Nov 19. Epub 2018 Nov 19.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Purpose: Texture analysis performed on MR images can detect quantitative features that are imperceptible to human visual assessment. The purpose of this study was to evaluate the feasibility of texture analysis on preoperative conventional MRI to discriminate between histological subtypes in low-grade gliomas (LGGs), and to determine the utility of texture analysis compared to histogram analysis alone.

Methods: A total of 41 patients with LGG, 21 astrocytoma and 20 1p/19q codeleted oligodendroglioma were included in this study. Read More

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November 2018
2 Reads

Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma.

J Clin Neurosci 2018 Nov 14. Epub 2018 Nov 14.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Sydney NeuroOncology Group, Sydney, Australia.

The role of maximal surgical debulking in isocitrate dehydrogenase (IDH) mutated anaplastic glioma prior to adjuvant radiation therapy remains uncertain. This study assessed the reduction in tumour volume following intensity modulated radiation therapy (IMRT) and temozolomide in this favourable and more responsive tumour pathology. 56 patients were managed from 2011 to 2014 and 53 had residual disease. Read More

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November 2018
1 Read

The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage.

Authors:
Ruurd Torensma

Cancers (Basel) 2018 Nov 12;10(11). Epub 2018 Nov 12.

Department of Tumorimmunology, Radboud Institute for Molecular Life Sciences, RadboudUMC, Geert Grooteplein 28, 6525GA Nijmegen, The Netherlands.

Current treatments for oligodendrogliomas are powerful but have a negative impact on the rest of the body. The bone marrow is damaged by the chemotherapeutics, but other parts of the body are also affected. In this paper, the current treatment method and its collateral damage is described. Read More

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November 2018
2 Reads

Multi-faceted computational assessment of risk and progression in oligodendroglioma implicates NOTCH and PI3K pathways.

NPJ Precis Oncol 2018 6;2:24. Epub 2018 Nov 6.

14Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.

Oligodendrogliomas are diffusely infiltrative gliomas defined by -mutation and co-deletion of 1p/19q. They have highly variable clinical courses, with survivals ranging from 6 months to over 20 years, but little is known regarding the pathways involved with their progression or optimal markers for stratifying risk. We utilized machine-learning approaches with genomic data from The Cancer Genome Atlas to objectively identify molecular factors associated with clinical outcomes of oligodendroglioma and extended these findings to study signaling pathways implicated in oncogenesis and clinical endpoints associated with glioma progression. Read More

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November 2018

[Intraoperative mapping of long association fibers in surgery of gliomas of the speech-dominant frontal lobe].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(5):5-20

Burdenko Neurosurgical Institute, Moscow, Russia.

Surgery of intracerebral tumors involving long association fibers is a challenge. In this study, we analyze the results of intraoperative mapping of the superior longitudinal, arcuate, and frontal aslant tracts in surgery of brain gliomas.

Purpose: The study purpose was to compare the results of intraoperative mapping and the postoperative speech function in patients with gliomas of the premotor area of the speech-dominant frontal lobe, which involved the superior longitudinal, arcuate, and frontal aslant tracts, who were operated on using awake craniotomy. Read More

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January 2018
11 Reads

High levels of glioma tumor suppressor candidate region gene 1 predicts a poor prognosis for prostate cancer.

Oncol Lett 2018 Nov 24;16(5):6749-6755. Epub 2018 Sep 24.

Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.

Glioma tumor suppressor candidate region gene 1 (GLTSCR1) is associated with the progression of oligodendroglioma. However, there has been little study of GLTSCR1 in prostate cancer. In the present study, the association between the expression of GLTSCR1, and the progression and prognosis of tumors in patients with prostate cancer was assessed. Read More

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November 2018
5 Reads
0.987 Impact Factor

Increased HSPG2 expression independently predicts poor survival in patients with oligoastrocytoma and oligodendroglioma.

Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6853-6863

Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China.

Objective: Perlecan, which is also called heparan sulfate proteoglycan 2 (HSPG2), is a protein encoded by the HSPG2 gene that maps to 1p36.12 in the human genome. In this study, we assessed the independent prognostic value of HSPG2 in terms of overall survival (OS) and recurrence-free survival (RFS) in patients with LGG. Read More

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October 2018
2 Reads

Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders.

Vet Med Sci 2018 Nov 5. Epub 2018 Nov 5.

Microspherix LLC, Bocan Raton, FL, USA.

Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. Read More

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November 2018
1 Read

Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.

Pathol Res Pract 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Weihui Health Road, Xinxiang 453000, Henan Province, People's Republic of China. Electronic address:

Background: Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, which is recently identified as a target gene of c-Myc and is frequently dysregulated in multiple cancers. This study aimed to explore the clinicpathological value and biological role of CDCA7L in glioma.

Methods: CDCA7L expression in glioma patients was determined using the Oncomine database, and the prognostic role of CDCA7L expression was assessed in a retrospective cohort study. Read More

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October 2018
1 Read

The effects of tumor size and postoperative radiotherapy for patients with adult low-grade (WHO grade II) infiltrative supratentorial astrocytoma/oligodendroglioma: A population-based and propensity score matched study.

Cancer Med 2018 Oct 30. Epub 2018 Oct 30.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Background: The update of 2018 NCCN guidelines (central nervous system cancers) recommended the risk classification of postoperative patients diagnosed as adult low-grade (WHO grade II) infiltrative supratentorial astrocytoma/oligodendroglioma (ALISA/O) should take tumor size into consideration. Moreover, the guidelines removed postoperative radiotherapy (PORT) for low risk patients. Our study aimed to explore the specific tumor size to divide postoperative patients into relatively low- or high risk subgroups and the effect of PORT for ALISA/O patients. Read More

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October 2018
5 Reads

Assessment of the impact of glioma diagnostic reclassification following the new 2016 WHO classification on a series of cases.

Neurocirugia (Astur) 2018 Oct 23. Epub 2018 Oct 23.

Servicio de Neurocirugía, Hospital General Universitario Gregorio Marañón, Madrid, España.

Background And Objectives: The aim of this project is to assess diagnostic reclassification based on molecular data over morphology in a series of glial tumours since the introduction of the 2016 WHO classification of brain tumours.

Materials And Methods: Retrospective review of glial tumours (oligodendrogliomas and astrocytomas) treated in our centre between January 2012 and June 2016 in which a review of diagnosis was performed when molecular studies were added. Statistical analysis included evaluation of variables of epidemiology, morphology and molecular data (mainly IDH mutation and 1p19q codeletion), diagnostic changes after new classification was considered, and clinical impact in cases of diagnostic reclassification. Read More

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October 2018
9 Reads

Anaplastic Glioma: Treatment Approaches in the Era of Molecular Diagnostics.

Curr Treat Options Oncol 2018 Oct 25;19(12):61. Epub 2018 Oct 25.

Division of Neuro-Oncology Mayo Clinic, Rochester, MN, USA.

Opinion Statement: The treatment paradigm for anaplastic glioma has shifted, owing to new diagnostic criteria and new phase III clinical trial evidence. In 2016, the WHO classification of brain tumors including diffuse gliomas was redefined to include molecular criteria, often supplanting the morphological appearance of the tumor cells. This was necessary as prognosis is more closely associated with molecular diagnosis than with morphology and grade. Read More

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October 2018
10 Reads

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

Int J Gynecol Cancer 2018 Nov;28(9):1650-1656

Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.

Objectives: Malignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC. Read More

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November 2018
3 Reads

Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis.

J Neurol Psychol 2017 Dec 23;5(1). Epub 2017 Dec 23.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, USA.

Sphingolipids are enriched in the Central Nervous System (CNS) and display multiple biological functions. They participate in tissue development, cell recognition and adhesion, and act as receptors for toxins. During myelination, a variety of interactive molecules such as myelin basic protein, myelin associated glycoprotein, phospholipids, cholesterol, sphingolipids, etc. Read More

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December 2017
1 Read

Prognostic significance of genetic biomarkers in isocitrate dehydrogenase-wild-type lower-grade glioma: the need to further stratify this tumor entity - a meta-analysis.

Eur J Neurol 2018 Oct 9. Epub 2018 Oct 9.

Department of Pathology, University of Yamanashi, Yamanashi, Japan.

The clinical outcomes of isocitrate dehydrogenase-wild-type (IDH-wt) lower-grade glioma (LGG) have been the subject of debate for some time. In this meta-analysis, we aimed to assess the prognostic values of several known genetic markers (e.g. Read More

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October 2018
3 Reads

Navigated Transcranial Magnetic Stimulation In A Patient With A Cranioplasty In Situ: A Safe And Accurate Procedure.

World Neurosurg 2018 Oct 5. Epub 2018 Oct 5.

Background: and importance: Navigated Transcranial Magnetic Stimulation (nTMS) is a non-surgical mapping technique used in mapping of motor and language eloquent areas within and / or surrounding brain tumours. Previous reports support this as a safe technique with minor side effects associated with minor headaches and discomfort around the stimulation area. Currently there are no published reports concerning the accuracy and safety of this procedure in patients with a titanium cranioplasty in situ. Read More

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October 2018
7 Reads

Diffuse low grade glioma after the 2016 WHO update, seizure characteristics, imaging correlates and outcomes.

Clin Neurol Neurosurg 2018 Dec 2;175:9-15. Epub 2018 Oct 2.

Department of Neurosurgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.

Objectives: The majority of patients with supratentorial diffuse grade II glioma present with seizures, which adversely affect quality of life. The exact mechanism of epileptogenesis is unknown and the influence of tumour characteristics, radiological and histological, are not well studied, particularly following the introduction of molecular genetics in the 2016 WHO reclassification of gliomas. We sought to define predictors of seizure development and outcome in low grade glioma. Read More

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December 2018
7 Reads

Radiotherapy plus temozolomide or PCV in patients with anaplastic oligodendroglioma 1p19q codeleted.

Rev Neurol 2018 Oct;67(8):293-297

Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico DF, Mexico.

Introduction: Radiotherapy with procarbazine, lomustine, and vincristine (PCV) improves overall survival in patients with anaplastic oligodendroglioma 1p19q codeleted.

Patients And Methods: This retrospective analysis investigated outcomes in patients with anaplastic oligodendroglioma 1p19q codeleted compared two different protocols (radiotherapy plus temozolomide or PCV). The primary end points were overall survival and progression-free survival. Read More

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October 2018
1 Read

Patterns of care and outcomes of postoperative radiation for low-grade gliomas in United States hospitals.

J Clin Neurosci 2018 Dec 2;58:124-129. Epub 2018 Oct 2.

Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY, USA; Department of Veterans Affairs, New York Harbor Healthcare System, Brooklyn, NY, USA; Summit Medical Group at MD Anderson Cancer Center, Berkeley Heights, NJ, USA.

It is unclear whether there is a survival benefit with postoperative radiation for low-grade gliomas deemed to be high-risk. We sought to analyze patterns of care and outcomes of radiation use. We accessed the National Cancer Database to identify patients with WHO grade II oligodendroglioma or astrocytoma between 2010 and 2012. Read More

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December 2018
2 Reads

Multiple Extraneural Metastases of Anaplastic Oligodendroglioma.

Asian J Neurosurg 2018 Jul-Sep;13(3):830-833

Department of Pathology, Faculty of Medicine, Adana Practice and Research Center, Baskent University, Adana, Turkey.

Oligodendrogliomas (ODGs) is a diffuse glial tumor that constitutes 4.2% of all brain tumors. Extraneural metastases, sometimes seen in glioblastoma multiforme, are extremely rare in ODG. Read More

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October 2018
6 Reads

Glioblastoma in the setting of prior lower grade gliomas - insights from SEER database.

Oncotarget 2018 Sep 7;9(70):33271-33277. Epub 2018 Sep 7.

National Skull Base Center, Thousand Oaks, CA, USA.

Introduction: Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after a lower grade glioma. Though knowledge regarding this subset has gained traction in recent years, its definition continues to evolve, complicating its clinical management. Investigation of epidemiology and survival patterns may help provide needed insights. Read More

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September 2018
9 Reads

Microvascular characteristics of lower-grade diffuse gliomas: investigating vessel size imaging for differentiating grades and subtypes.

Eur Radiol 2018 Oct 1. Epub 2018 Oct 1.

Department of Radiology, Institute of Surgery Research, Daping Hospital, Army Medical University, 10# Changjiang Branch Road, Chongqing, People's Republic of China, 400024.

Objectives: Vessel size imaging (VSI) could reveal average microvessel diameter. The aim was to investigate microvascular characteristics and the efficacy of VSI in lower-grade glioma (LGG) grading and subtype differentiation based on 2016 classification of central nervous system tumours.

Methods: Fifty-seven LGG (grade II/III, 36/21) patients who received VSI examination before surgery were retrospectively analysed. Read More

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October 2018
1 Read

Comparison of Radiation Therapy Alone and Chemotherapy Alone for Low-Grade Gliomas without Surgical Resection.

World Neurosurg 2018 Sep 24. Epub 2018 Sep 24.

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Background: The combined use of chemotherapy (CT) and radiotherapy (RT) is becoming increasingly common in the treatment of surgically resected low-grade gliomas. However, whether RT or CT is associated with improved overall survival (OS) for low-grade gliomas without surgical resection is less clear.

Methods: The U. Read More

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September 2018
2 Reads
2.420 Impact Factor

Gliosarcoma arising from oligodendroglioma (Oligosarcoma): A case report with genetic analyses.

Pathol Int 2018 Oct 23;68(10):567-573. Epub 2018 Sep 23.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Gliosarcomas are a type of bimorphic tumor composed of glial and sarcomatous elements, and are considered to be a variant of glioblastoma, WHO grade IV. To date, only rare cases of gliosarcoma with oligodendroglial components (oligosarcoma) have been reported. We report a case of oligosarcoma consisting of gliosarcoma arising from recurrent oligodendroglioma. Read More

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October 2018
3 Reads

Probable pathogenesis, diagnosis, and management of untreated arteriovenous malformation with cyst formation: case report and literature review.

Acta Neurol Belg 2018 Dec 21;118(4):603-605. Epub 2018 Sep 21.

Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5 Fu-Shin Street, Gui-Shan Dist., Taoyuan, 33305, Taiwan, Republic of China.

Arteriovenous malformations (AVMs) usually manifest as headaches, seizures, focal neurological signs, and spontaneous intracerebral or subarachnoid hemorrhages. An untreated AVM with associated cyst formation is extremely rare, and the probable pathogenesis is unclear. We propose and discuss the possible pathogenesis of this condition and its diagnosis and management. Read More

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December 2018
6 Reads

A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma.

J Neuropathol Exp Neurol 2018 Nov;77(11):1039-1054

National Cancer Institute, National Institutes of Health, Comparative Oncology Program, Center for Cancer Research, Bethesda, Maryland.

The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology board, comprising both veterinarian and physician neuropathologists, and conducted a comprehensive review of 193 cases of canine glioma. The immediate goal was to improve existing glioma classification methods through creation of a histologic atlas of features, thus yielding greater harmonization of phenotypic characterization. The long-term goal was to support future incorporation of clinical outcomes and genomic data into proposed simplified diagnostic schema, so as to further bridge the worlds of veterinary and physician neuropathology and strengthen validity of the dog as a naturally occurring, translationally relevant animal model of human glioma. Read More

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November 2018
9 Reads

[Prognostic significance of combined TERT and IDH gene mutation analysis in diffusely infiltrating gliomas].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):658-663

Department of Pathology, West China Hospital, Chengdu 610041, China.

To investigate the status and prognostic significance of TERT and IDH1/2 genes mutations in diffusely infiltrating gliomas. Hot spot mutations of TERT and IDH1/2 genes were detected by DNA sequencing in 236 cases of gliomas at West China Hospital from 2012 to 2016, including pilocytic astrocytoma (WHO grade Ⅰ, 16 cases), diffuse astrocytoma and oligodendroglioma (WHO grade Ⅱ, 89 cases), anaplastic astrocytoma and oligodendroglioma (WHO grade Ⅲ, 72 cases) and glioblastoma (WHO grade Ⅳ, 59 cases). The prognostic significance of TERT and IDH1/2 hot spot mutations was evaluated. Read More

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September 2018
7 Reads

Fluorescein-Guided Surgery for Pediatric Brainstem Gliomas: Preliminary Study and Technical Notes.

J Neurol Surg B Skull Base 2018 Oct 25;79(Suppl 4):S340-S346. Epub 2018 Jun 25.

Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China.

 Brainstem gliomas (BsG) account for 10 to 15% of pediatric brain tumors. Surgery is the preferred treatment for focal and exophytic lesions. Sodium fluorescein has been proven safe and effective in resection of malignant brain tumors. Read More

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October 2018
10 Reads

Primary Leptomeningeal Oligodendroglioma, IDH-Mutant, 1p/19q-Codeleted.

Front Neurol 2018 27;9:700. Epub 2018 Aug 27.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.

We present a case of a 43-year-old woman with a history of headaches and blurry vision. Ophthalmologic examination identified papilledema. MR imaging demonstrated a right parietal region mass with patchy areas of contrast enhancement and focal calcifications. Read More

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August 2018
6 Reads

The prognostic value of maximal surgical resection is attenuated in oligodendroglioma subgroups of adult diffuse glioma: a multicenter retrospective study.

J Neurooncol 2018 Dec 11;140(3):591-603. Epub 2018 Sep 11.

Department of Neurosurgery, Huashan Hospital, Fudan University, 12# Mid Wulumuqi Road, Shanghai, China.

Purpose: Maximal surgical resection is associated with survival benefit in the majority of studies in adult diffuse glioma. This study aims to characterize the prognostic value of surgical resection in molecular subgroups of diffuse glioma.

Methods: 1178 patients with diffuse glioma from our centers and 422 from TCGA dataset were collected. Read More

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December 2018
4 Reads
3.070 Impact Factor

Erratum: Author Correction: Identification and targeting of an FGFR fusion in a pediatric thalamic "central oligodendroglioma".

NPJ Precis Oncol 2018 25;2:12. Epub 2018 Apr 25.

1Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 USA.

[This corrects the article DOI: 10.1038/s41698-017-0036-8.]. Read More

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Somatostatin receptor 2A protein expression characterizes anaplastic oligodendrogliomas with favorable outcome.

Acta Neuropathol Commun 2018 Sep 7;6(1):89. Epub 2018 Sep 7.

APHM, Hôpital de la Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France.

Diffuse gliomas are classified according to the 2016 WHO Classification of Tumors of the Central Nervous System, which now defines entities by both histology and molecular features. Somatostatin receptor subtype 2A (SSTR2A) expression has been reported in various solid tumors as associated with favorable outcomes. Its expression has been reported in gliomas with uncertain results regarding its prognostic value. Read More

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September 2018
14 Reads

Anaplastic oligodendroglioma with leptomeningeal dissemination in a french bulldog.

J Vet Med Sci 2018 Nov 6;80(10):1590-1595. Epub 2018 Sep 6.

Kyoto Animal Referral Medical Center, 208-4, Shinarami, Tai, Kumiyama-cho, Kuze-gun, Kyoto 613-0036, Japan.

A 2.5-year-old male French Bulldog was evaluated for seizures. Cranial magnetic resonance imaging (MRI) suggested a glioma in the left piriform area. Read More

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November 2018

Elucidating the molecular pathogenesis of glioma: integrated germline and somatic profiling of a familial glioma case series.

Neuro Oncol 2018 Nov;20(12):1625-1633

Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Background: The genomic characterization of sporadically arising gliomas has delineated molecularly and clinically distinct subclasses of disease. However, less is known about the molecular nature of gliomas that are familial in origin. We performed molecular subtyping of 163 tumor specimens from individuals with a family history of glioma and integrated germline and somatic genomic data to characterize the pathogenesis of 20 tumors in additional detail. Read More

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November 2018
1 Read

[Li-Fraumeni syndrome in a patient with multiple anaplastic oligodendrogliomas of the brain (a case report and literature review)].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(4):87-96

Neurological Center of Latium, Rome, Italy; Department of Biomedicine, University of Rome Tor Vergata and NCL-Institute of Neurological Sciences, Rome, Italy.

Li-Fraumeni syndrome (LFS) is a clinically and genetically heterogeneous hereditary syndrome with predominantly oncological manifestations, which is associated with mutations in the TP53, MDM2, and CHEK2 genes. The most common variant is a TP53 mutation.

Objective: To analyze the literature and present a clinical case of a patient with Li-Fraumeni syndrome and multiple anaplastic oligodendrogliomas of the brain. Read More

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January 2018
2 Reads

[A Case of Bone Marrow Metastasis of Oligodendroglioma with IDH Mutation and 1p/19q Codeletion].

No Shinkei Geka 2018 Aug;46(8):699-706

Department of Neurosurgery, Asahi General Hospital.

A 71-year-old woman was transferred to our hospital, complaining of a seizure for the first time. A tumor was detected in the right frontal lobe, and a craniotomy was performed with a partial tumor resection. The pathological diagnosis was oligodendroglioma with IDH mutation and 1p/19q codeletion, and irradiation therapy was performed. Read More

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August 2018
5 Reads

Primary central nervous system neoplasms in African hedgehogs.

J Vet Diagn Invest 2018 Sep 22;30(5):715-720. Epub 2018 Aug 22.

Diagnostic Medicine Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Muñoz-Gutiérrez).

In this retrospective study, we describe the clinicopathologic and immunohistochemical findings in a series of primary central nervous system (CNS) neoplasms in African hedgehogs ( Atelerix albiventris). Twelve CNS neoplasms were found among 762 African hedgehog submissions (1.6%) to a private diagnostic laboratory in an 18-y period. Read More

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September 2018
5 Reads

Impact of adjuvant treatments on survival in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study.

J Neurooncol 2018 Nov 10;140(2):445-455. Epub 2018 Aug 10.

Department of Radiation Oncology, Konkuk University Medical Center, School of Medicine, Konkuk University, Seoul, South Korea.

Introduction: Optimal treatment strategies for low-grade glioma (LGG) remain controversial. We analyzed treatment outcomes and evaluated prognostic factors of adult LGG patients in Korea.

Methods: We reviewed the medical records of 555 patients diagnosed with WHO grade II LGG (astrocytoma 37. Read More

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November 2018
5 Reads
3.070 Impact Factor

Freiburg Neuropathology Case Conference : Tumor of the Mesiotemporal Lobe in a Child.

Clin Neuroradiol 2018 09;28(3):461-466

Department of Neuropathology, Medical Centre, University of Freiburg, Freiburg, Germany.

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September 2018

Long-term clinical and seizure outcomes of insular gliomas via trans-opercular approach.

Clin Neurol Neurosurg 2018 Oct 2;173:52-57. Epub 2018 Aug 2.

Departments of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Objective: To report long-term clinical and seizure outcomes of patients who were operated upon insular gliomas via trans-opercular approach.

Patients And Methods: Since 2010, surgical resection of insular gliomas was performed via trans-opercular approach by our group. Clinical, surgical and follow-up results were analyzed retrospectively. Read More

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October 2018
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Central Nervous System-type Neuroepithelial Tumors and Tumor-like Proliferations Developing in the Gynecologic Tract and Pelvis: Clinicopathologic Analysis of 23 Cases.

Am J Surg Pathol 2018 Nov;42(11):1429-1444

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD.

Central nervous system (CNS)-type tumors and tumor-like proliferations arising in the gynecologic tract and pelvis are rare. Clinicopathologic features of 23 cases are reported using the current WHO classification system for CNS tumors, with selected relevant immunohistochemical and molecular genetic analyses when possible. There were 12 embryonal tumors, including 7 medulloepitheliomas, 2 embryonal tumors (not otherwise specified), 1 embryonal tumor with multilayered rosettes, 1 embryonal tumor with features of nodular desmoplastic medulloblastoma, and 1 medulloblastoma with extensive nodularity, with primary sites including ovary (7), uterus/endometrium (3), and pelvis (2). Read More

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November 2018
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Grade II and III Oligodendroglioma and Astrocytoma.

Neurol Clin 2018 Aug 15;36(3):467-484. Epub 2018 Jun 15.

Department of Neurosurgery, University of California, San Francisco, Box 0112, 505 Parnassus Avenue M779, San Francisco, CA 94143, USA.

In the 2016 WHO classification of diffuse glioma, the diagnosis of an (anaplastic) oligodendroglioma requires the presence of both an IDH mutation (mt) and 1p/19q codeletion, whereas (anaplastic) astrocytoma are divided in IDH wild-type and IDHmt tumors. Standard of care for grade II and III glioma consists of resection. For patients with tumors that require postoperative treatment, radiotherapy and chemotherapy are recommended. Read More

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August 2018
6 Reads