1,224 results match your criteria Ogilvie Syndrome


Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

Am J Hum Genet 2019 Apr 10. Epub 2019 Apr 10.

Molecular Neurosciences, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK. Electronic address:

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193010
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http://dx.doi.org/10.1016/j.ajhg.2019.03.005DOI Listing
April 2019
7 Reads

[Ogilvie syndrome - case report].

Wiad Lek 2019 ;72(2):302-304

Oddział Chirurgii Ogólnej, Szpital Miejski w Siemianowicach Śląskich, Siemianowice Śląskie, Polska.

Ogilvie syndrome is a clinical condition in which there is a colorectal distention in the absence of mechanical obstacles. Early diagnosis and appropriate therapy significantly reduce mortality. The incidence of this is not known. Read More

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January 2019
1 Read

Ogilvie syndrome in a 8 year old girl after laparoscopic appendectomy.

BMC Pediatr 2019 Mar 20;19(1):82. Epub 2019 Mar 20.

Pediatrics, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Ogilvie's syndrome is described in the adult population, but rarely seen in children.

Case Presentation: We present a case of a girl who suffered acute colonic pseudo-obstruction after laparoscopic appendectomy.

Conclusions: Ogilvie's syndrome, although rare in the pediatric population, should be considered as possible diagnosis after a surgical procedure in presence of persisting subocclusive symptoms and radiological signs of massive colonic dilatation without mechanical obstruction. Read More

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http://dx.doi.org/10.1186/s12887-019-1457-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425584PMC
March 2019
1 Read

Acute Colonic Pseudo-Obstruction Caused by Dexmedetomidine: A Case Report and Literature Review.

Am J Case Rep 2019 Mar 3;20:278-284. Epub 2019 Mar 3.

Department of Internal Medicine, BronxCare Health System, Bronx, NY, USA.

BACKGROUND Acute colonic pseudo-obstruction (ACPO) is an infrequent entity characterized by non-toxic, non-mechanical, abrupt, functional dilation of the colon. Clinically patients present with abdominal distention, anxiety, severe abdominal pain, nausea, and vomiting. This rare entity can lead to a fatal outcome if not recognized early. Read More

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http://dx.doi.org/10.12659/AJCR.913645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410604PMC
March 2019
3 Reads

Prucalopride for the treatment of constipation: a view from 2015 and beyond.

Expert Rev Gastroenterol Hepatol 2019 Mar 23;13(3):257-262. Epub 2019 Jan 23.

c Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery , University of Pisa , Pisa , Italy.

Introduction: Prucalopride is a prokinetic drug, that has been commercially available in recent years for the treatment of chronically constipated patients. In this update of a previous 2016 article, we reviewed the more recent data supporting its role in the treatment of constipation and constipation-associated conditions. Areas covered: We carried out an extensive literature review on the effects of prucalopride for the years 2012-2018 by means of scientific databases and manual research. Read More

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http://dx.doi.org/10.1080/17474124.2019.1568238DOI Listing
March 2019
2 Reads

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

Nat Commun 2019 02 15;10(1):883. Epub 2019 Feb 15.

CHU Sainte-Justine Research Center, Montreal, QC, H3T 1C5, Canada.

The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-019-08800-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377600PMC
February 2019
4 Reads
10.742 Impact Factor

[Acute colonic pseudo-obstruction after caesarean section; Ogilvie's syndrome].

Ned Tijdschr Geneeskd 2019 Feb 7;163. Epub 2019 Feb 7.

Ikazia Ziekenhuis, afd. Gynaecologie en Verloskunde, Rotterdam.

Background: Acute pseudo-obstruction of the colon - also known as Ogilvie's syndrome - is a rare clinical presentation in obstetrics. The syndrome is seen more often following caesarean section than vaginal delivery.

Case Description: We present a 38-year-old primigravida who developed Ogilvie's syndrome following secondary caesarean section. Read More

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February 2019
2 Reads

Idiopathic Dilatation of the Colon in a Nursing Home Resident, with a Suspected Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome).

J Coll Physicians Surg Pak 2019 Feb;29(2):178-180

Department of Surgery, Fourth Military Teaching Hospital, 5 Weigla Street, 50-981 Wroclaw, Poland.

Ogilvie syndrome (acute colonic pseudo-obstruction) represents a clinical condition with symptoms of colonic obstruction without a distinct mechanical factor. The damage to the neural ganglia in the intestinal wall is the most likely etiology. A 62-year man was admitted to the Emergency Department due to acute dyspnea and vomiting. Read More

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https://www.jcpsp.pk/archive/2019/Feb2019/19.pdf
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http://dx.doi.org/10.29271/jcpsp.2019.02.178DOI Listing
February 2019
14 Reads

Maternal short-term complications after planned cesarean delivery without medical indication: A registry-based study.

Acta Obstet Gynecol Scand 2019 Jan 30. Epub 2019 Jan 30.

Department of Gynecology and Obstetrics, Holbaek Hospital, Holbaek, Denmark.

Introduction: To compare short-term maternal outcomes in healthy primiparous women with uncomplicated pregnancies who delivered a singleton child at term by planned cesarean or planned vaginal delivery.

Material And Methods: Nationwide population-based cohort study of 145 821 low-risk primiparous women with healthy singletons in cephalic position in Denmark, 2008-2016. Data from the Medical Birth Register and the Danish National Patient Registry were linked and compared according to planned mode of delivery. Read More

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http://dx.doi.org/10.1111/aogs.13549DOI Listing
January 2019
5 Reads

A rare complication of cardiac surgery: Ogilvie syndrome.

J Postgrad Med 2019 Jan-Mar;65(1):56-57

Department of Faculty Surgery, South Ural State Medical University, Chelyabinsk, Russia.

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http://dx.doi.org/10.4103/jpgm.JPGM_405_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380123PMC
January 2019

Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility.

J Neurogastroenterol Motil 2019 Jan;25(1):137-147

Departments of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background/aims: Previous studies from Korea have described chronic intestinal pseudo-obstruction (CIPO) patients with transition zone (TZ) in the colon. In this study, we evaluated the pathological characteristics and their association with long-term outcomes in Korean colonic pseudo-obstruction (CPO) patients with TZ.

Methods: We enrolled 39 CPO patients who were refractory to medical treatment and underwent colectomy between November 1989 and April 2016 (median age at symptoms onset: 45 [interquartile range, 29-57] years, males 46. Read More

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http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm1
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http://dx.doi.org/10.5056/jnm18121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326194PMC
January 2019
17 Reads

Pneumatosis intestinalis and hepatic portal venous gas associated with gas-forming bacterial translocation due to postoperative paralytic ileus: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14079

Department of Diagnostic Pathology.

Rationale: Pneumatosis intestinalis (PI) and hepatic portal venous gas (HPVG) are rare but potentially lethal conditions in which gas pathologically accumulates in the portal vein and intestinal wall, respectively. Proposed mechanisms include flatus escaping through an injured intestinal mucosa into the submucosa and thence into the portal venous system, or bacterial translocation (BT) of gas-forming enteric microorganisms from the gut into and through the intestinal wall to other organs. However, there has been no clear histopathological evidence to support these hypotheses. Read More

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http://dx.doi.org/10.1097/MD.0000000000014079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336625PMC
January 2019
13 Reads

Laparoscopic subtotal colectomy for a patient with chronic idiopathic colonic pseudo-obstruction: Report of a case.

Asian J Endosc Surg 2019 Jan 7. Epub 2019 Jan 7.

Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.

A 47-year-old male patient without a documented past medical history was referred to Sanno Hospital because of constipation and abdominal pain, which he had had for more than 5 years. Abdominal X-ray and CT scan showed an enlarged ascending colon from the cecum to the transverse colon, without apparent mechanical obstruction. The patient was diagnosed with chronic idiopathic colonic pseudo-obstruction, and because his symptoms were resistant to medication, surgical treatment was required. Read More

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http://dx.doi.org/10.1111/ases.12682DOI Listing
January 2019
3 Reads

Histological characteristics of eosinophilic myenteric ganglionitis: an under-recognised cause of chronic intestinal pseudo-obstruction.

Virchows Arch 2019 Mar 4;474(3):395-400. Epub 2019 Jan 4.

Department of Human Pathology, School of Medicine, Juntendo University, 1-1-19 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.

Eosinophilic myenteric ganglionitis (EMG) is characterised by eosinophilic infiltration of the myenteric plexus. EMG has been rarely reported as a cause of chronic intestinal pseudo-obstruction (CIPO), and its histopathological features are not fully elucidated. We analysed seven patients with CIPO. Read More

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http://dx.doi.org/10.1007/s00428-018-02513-5DOI Listing
March 2019
3 Reads

Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study.

Turk J Gastroenterol 2019 Mar;30(3):228-233

Department of Anaesthesiology, Selçuk University School of Medicine, Konya, Turkey.

Background/aims: When conservative methods fail, neostigmine is recommended in the pharmacological treatment of acute colonic pseudo-obstruction (ACPO). The objective of this study was to analyze the response of patients to different neostigmine protocols.

Materials And Methods: Patients diagnosed with ACPO in the intensive care unit between January 2015 and September 2017 were retrospectively studied. Read More

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http://dx.doi.org/10.5152/tjg.2018.18193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428512PMC

Ogilvie's Syndrome or Colonic Pseudo-Obstruction.

Am Surg 2018 Jan;84(1):e38-e39

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January 2018
1 Read

Ogilvie Syndrome with Caecal Perforation After Caesarean Section.

J Obstet Gynaecol India 2018 Dec 27;68(6):498-501. Epub 2018 Jan 27.

Aayush Hospitals, Vijayawada, Andhrapradesh India.

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http://dx.doi.org/10.1007/s13224-017-1081-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207549PMC
December 2018

Deletion of IPR1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality.

J Gastroenterol 2019 May 31;54(5):407-418. Epub 2018 Oct 31.

Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.

Background: Inositol 1,4,5-trisphosphate receptors (IPRs) are a family of intracellular Ca release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological functions. However, their function in regulating gastrointestinal (GI) tract motility in vivo remains unknown. Here, we investigated the physiological function of IPR1 in the GI tract using genetically engineered mouse models. Read More

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http://link.springer.com/10.1007/s00535-018-1522-7
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http://dx.doi.org/10.1007/s00535-018-1522-7DOI Listing
May 2019
5 Reads

Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction.

J Intensive Care Med 2018 Oct 29:885066618809010. Epub 2018 Oct 29.

1 Department of Pharmacotherapy and Pharmacy Services, University Health System, San Antonio, TX, USA.

Purpose:: To compare clinical response of intermittent bolus versus continuous infusion neostigmine for acute colonic pseudo-obstruction (ACPO). Acute colonic pseudo-obstruction occurs due to reduced colonic parasympathetic activity. Neostigmine is an acetylcholinesterase inhibitor that increases frequency of smooth muscle contraction by increasing acetylcholine at autonomic nervous system synapses. Read More

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http://journals.sagepub.com/doi/10.1177/0885066618809010
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http://dx.doi.org/10.1177/0885066618809010DOI Listing
October 2018
25 Reads

Ogilvie syndrome presenting with septic shock.

Turk J Pediatr 2018 ;60(2):225-227

Division of Pediatric Intensive Care Unit, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Özsoylu S, Akyıldız BN, Dursun A. Ogilvie syndrome presenting with septic shock. Turk J Pediatr 2018; 60: 225-227. Read More

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http://www.turkishjournalpediatrics.org/doi.php?doi=10.24953
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http://dx.doi.org/10.24953/turkjped.2018.02.020DOI Listing
January 2018
16 Reads

Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill.

Nutr Clin Pract 2019 Feb 7;34(1):23-36. Epub 2018 Oct 7.

Department of Neuro-Gastroenterology, University College London, London, UK.

Gastrointestinal dysmotility causes delayed gastric emptying, enteral feed intolerance, and functional obstruction of the small and large intestine, the latter functional obstructions being frequently termed ileus and Ogilvie syndrome, respectively. In addition to meticulous supportive care, drug therapy may be appropriate in certain situations. There is, however, considerable variation among individuals regarding what gastric residual volume identifies gastric dysmotility and would encourage use of a promotility drug. Read More

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http://doi.wiley.com/10.1002/ncp.10199
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http://dx.doi.org/10.1002/ncp.10199DOI Listing
February 2019
7 Reads

Ogilvie syndrome following pediatric scoliosis surgery.

J Musculoskelet Neuronal Interact 2018 Sep;18(3):399-401

University of Calgary Cumming School of Medicine, Calgary, AB, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146187PMC
September 2018
2 Reads

Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report.

A A Pract 2019 Jan;12(2):44-46

Vanderbilt University School of Medicine/Vanderbilt University Medical Center, Nashville, Tennessee.

Pain management with opioids is often limited by medication side effects. One of the most common and distressing side effects is opioid-induced constipation (OIC), a syndrome that is now getting significant national attention. We report the case of an opioid-dependent 56-year-old man who underwent lumbar decompression for spinal stenosis. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000840DOI Listing
January 2019
13 Reads

Intestinal pseudo-obstruction caused by herpes zoster: Case report and pathophysiology.

World J Clin Cases 2018 Jun;6(6):132-138

Division of Research at Autonomous University of Guadalajara, Guadalajara, JAL 45200, México.

Herpes zoster (HZ) infection occurs in approximately 10% to 30% of individuals. Visceral neuropathies secondary to HZ can cause cystitis and urinary retention. But colonic pseudo-obstruction can also occur. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i6.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033747PMC
June 2018
6 Reads

Ogilvie's syndrome: management and outcomes.

Medicine (Baltimore) 2018 Jul;97(27):e11187

Department of Internal Medicine and the Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC.

Ogilvie's syndrome, also known as acute colonic pseudo-obstruction, refers to pathologic dilation of the colon without underlying mechanical obstruction, occurring primarily in patients with serious comorbidities. Diagnosis of Ogilvie's syndrome is based on clinical and radiologic grounds, and can be treated conservatively or with interventions such as acetylcholinesterase inhibitors (such as neostigmine), decompressive procedures including colonoscopy, and even surgery. Based on our clinical experience we hypothesized that conservative management yields similar, if not superior, results to interventional management. Read More

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http://dx.doi.org/10.1097/MD.0000000000011187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076157PMC
July 2018
37 Reads

The B-ADENOMA Study: Bowelscope - Accuracy of Detection using Endocuff Optimisation of Mucosal Abnormalities: Study Protocol for randomised controlled trial.

Endosc Int Open 2018 Jul 4;6(7):E872-E877. Epub 2018 Jul 4.

South Tyneside NHS Foundation Trust - Gastroenterology, South Shields, Tyne and Wear, United Kingdom of Great Britain and Northern Ireland.

Background And Study Aims:  UK Bowel Cancer Screening flexible sigmoidoscopy (BowelScope) currently offers patients aged 55 a one-off flexible sigmoidoscopy for adenoma clearance to decrease colorectal cancer incidence by interrupting the adenoma-carcinoma sequence. Recent evidence has shown maximum benefit in increasing adenoma detection rate (ADR) using the Endocuff Vision device in the left side of the colon and in screening patients. Currently, ADR is low and shows unacceptable variation in BowelScope. Read More

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http://dx.doi.org/10.1055/a-0591-9308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032634PMC
July 2018
5 Reads

Post-Pneumonectomy ARDS and Ogilvie Syndrome - A Case Report.

J Crit Care Med (Targu Mures) 2018 Jan 9;4(1):34-37. Epub 2018 Feb 9.

"Marius Nasta" Pneumophtisiology Institute, Bucharest, Romania.

Introduction: The Acute Respiratory Distress Syndrome (ARDS) is a severe hypoxemic acute lung injury that may complicate lung resections. Reported mortality is very high, up to 50%. This report covers an ARDS case occurring post left pneumonectomy, with a favorable outcome, despite association with an acute colonic pseudo-obstruction syndrome (Ogilvie syndrome) that required abdominal surgery for decompression. Read More

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http://dx.doi.org/10.1515/jccm-2018-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953262PMC
January 2018
4 Reads

Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis.

Sleep 2018 08;41(8)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.

Study Objectives: To investigate the prevalence of concurrent periodic limb movements during sleep (PLMS) and restless leg syndrome (RLS), as well as the prevalence of PLMS and RLS separately. Additionally, we document these prevalences by age, race/ethnicity, sex, and obesity status.

Methods: Cross-sectional data from 2041 Multi-Ethnic Study of Atherosclerosis (MESA) Sleep ancillary study participants were used. Read More

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http://dx.doi.org/10.1093/sleep/zsy106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093310PMC
August 2018
22 Reads

Chilaiditi's Sign Associated with Acute Colonic Pseudo-obstruction: A Radiological Diagnosis.

Cureus 2018 Mar 20;10(3):e2351. Epub 2018 Mar 20.

Associate Professor of Medicine Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center.

Chilaiditi's sign is a rare radiological anomaly of hepato-diaphragmatic interposition of the bowel. We report a case of Chilaiditi's sign associated with acute colonic pseudo-obstruction. A 90-year-old male was admitted for hypertensive emergency. Read More

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http://dx.doi.org/10.7759/cureus.2351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959307PMC
March 2018
4 Reads

Abdominal Wall Pseudohernia and Colonic Pseudo-obstruction as Complications of Herpes Zoster.

Clin Gastroenterol Hepatol 2019 Mar 30;17(4):A26. Epub 2018 Apr 30.

Department of Neurology, Tenri Hospital, Tenri, Nara, Japan.

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http://dx.doi.org/10.1016/j.cgh.2018.04.051DOI Listing
March 2019
3 Reads

Colonic perforation associated with sodium polystyrene sulfonate (Kayexalate) use.

Diagn Interv Imaging 2018 Jul - Aug;99(7-8):507-509. Epub 2018 Apr 4.

Department of Medical Imaging, Lapeyronie Hospital, University Hospital of Montpellier, 191, avenue du Doyen-Gaston-Giraud, 34090 Montpellier, France.

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https://linkinghub.elsevier.com/retrieve/pii/S22115684183006
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http://dx.doi.org/10.1016/j.diii.2018.02.003DOI Listing
April 2018
13 Reads

Methylnaltrexone for Neostigmine-Resistant Ogilvie Syndrome.

Am J Ther 2018 Nov/Dec;25(6):e727-e728

Department of Internal Medicine, Northwell long Island Jewish Foresh Hills Hospital, Forest hills, NY.

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http://Insights.ovid.com/crossref?an=00045391-900000000-9865
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http://dx.doi.org/10.1097/MJT.0000000000000743DOI Listing
March 2019
8 Reads

Fluoroscopy-guided trans-anal decompression tube placement in the treatment of acute colonic pseudo-obstruction: a single center experience.

Abdom Radiol (NY) 2018 Oct;43(10):2643-2650

Department of General Surgery, Jinling Hospital, Medicine School of Nanjing University, No. 305 East Zhongshan Road, Nanjing, 210002, China.

Purpose: Acute colonic pseudo-obstruction (ACPO or Ogilvie's syndrome) is a rare but often fatal disease; timely colonic decompression may be essential for successful treatment. This study describes a technique of placing a trans-anal tube via fluoroscopy-guiding and investigates the effect of colon decompression on ACPO.

Methods: Patients undergoing colonic decompression via fluoroscopy-guided trans-anal tube placement from April 2015 to May 2017 were included. Read More

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http://dx.doi.org/10.1007/s00261-018-1509-0DOI Listing
October 2018
16 Reads

Respiratory symptoms of an abdominal origin.

BMJ Case Rep 2018 Feb 12;2018. Epub 2018 Feb 12.

Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

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http://dx.doi.org/10.1136/bcr-2017-224098DOI Listing
February 2018
2 Reads

A rare case report of multiple myeloma presenting with paralytic ileus and type II respiratory failure due to hypercalcemic crisis.

Medicine (Baltimore) 2017 Dec;96(52):e9215

Department of Gastrointestinal Surgery, First Hospital of Jilin University.

Rationale: Paralytic ileus is characterized by the signs and symptoms of intestinal obstruction but without any mechanical lesions in the intestinal lumen. Several medical and surgical conditions can lead to this ailment, such as electrolyte disturbances that impair intestinal motility. However, hypercalcemia secondary to multiple myeloma as a major cause of paralytic ileus has rarely been reported. Read More

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http://Insights.ovid.com/crossref?an=00005792-201712290-0001
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http://dx.doi.org/10.1097/MD.0000000000009215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393021PMC
December 2017
15 Reads

Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation.

Ann Pharmacother 2018 Jun 23;52(6):505-512. Epub 2018 Jan 23.

1 Duke University Hospital, Durham, NC, USA.

Background: Neostigmine is traditionally administered intravenously for treatment of acute colonic pseudo-obstruction (ACPO), though use is associated with administration constraints and adverse effects.

Objective: To evaluate whether an alternative route of administration for neostigmine via subcutaneous (SQ) delivery is safe and effective in a broad cohort of medical and surgical patients.

Methods: This multicenter, retrospective observational study included adult patients administered SQ neostigmine for ileus, ACPO, or refractory constipation. Read More

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http://dx.doi.org/10.1177/1060028018754302DOI Listing
June 2018
10 Reads

[Ankle arthroscopy for ankle impingement syndrome through anterior and posterior passage].

Zhongguo Gu Shang 2016 Dec;29(12):1078-1083

Department of Joint Trauma, the Third Hospital Affiliated to Sun Yat-Sen university, Guangzhou 510000, Guangdong, China;

Objective: To analyze clinical efficiency and intraoperative considerations of ankle arthroscopy for ankle impingement syndrome through anterior and posterior passage.

Methods: From April 2011 to April 2015, the clinical data of 17 patients diagnosed as ankle impingement syndrome were performed arthroscopy, including 12 males and 5 females, with an average age of 32.4 years (ranging from 22 to 47). Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2016.12.003DOI Listing
December 2016
8 Reads

Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.

Am J Hum Genet 2018 01 21;102(1):175-187. Epub 2017 Dec 21.

Manchester Centre for Genomic Medicine, Division of Evolution & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9WL, UK; Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester M13 9WL, UK. Electronic address:

Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene regulation. Here we demonstrate that variants causing haploinsufficiency of KMTs and KDMs are frequently encountered in individuals with developmental disorders. Using a combination of human variation databases and existing animal models, we determine 22 KMTs and KDMs as additional candidates for dominantly inherited developmental disorders. Read More

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http://dx.doi.org/10.1016/j.ajhg.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778085PMC
January 2018
36 Reads

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities.

Neurogastroenterol Motil 2018 Jan;30(1)

Department of Radiology and Nuclear Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.

Dynamic magnetic resonance imaging (MRI) of gastrointestinal motility has developed rapidly over the past few years. The non-invasive and non-ionizing character of MRI is an important advantage together with the fact that it is fast and can visualize the entire gastrointestinal tract. Advances in imaging and quantification techniques have facilitated assessment of gastric, small intestinal, and colonic motility in a clinical setting. Read More

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http://dx.doi.org/10.1111/nmo.13257DOI Listing
January 2018
9 Reads

Acute colonic distension in a patient with severe muscular dystrophy receiving non-invasive positive pressure ventilation.

Neuromuscul Disord 2018 Jan 29;28(1):60-61. Epub 2017 Sep 29.

Institute of Otorlaryngology, Department of Neurosciences, University-City Hospital of Padova, Via Giustiniani 2, Padova, Italy.

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http://dx.doi.org/10.1016/j.nmd.2017.09.012DOI Listing
January 2018
8 Reads

Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15.

Br J Pharmacol 2018 02 11;175(4):656-677. Epub 2018 Jan 11.

College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia.

Background And Purpose: Gastrointestinal side effects of chemotherapy are an under-recognized clinical problem, leading to dose reduction, delays and cessation of treatment, presenting a constant challenge for efficient and tolerated anti-cancer treatment. We have found that oxaliplatin treatment results in intestinal dysfunction, oxidative stress and loss of enteric neurons. BGP-15 is a novel cytoprotective compound with potential HSP72 co-inducing and PARP inhibiting properties. Read More

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http://dx.doi.org/10.1111/bph.14114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786462PMC
February 2018
15 Reads

Effect of Daikenchuto (TJ-100) on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: study protocol for a randomized controlled trial.

Trials 2017 Nov 21;18(1):553. Epub 2017 Nov 21.

Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin- Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Postoperative paralytic ileus can be a difficult complication for both surgeons and patients. Causes and treatments have been discussed for more than two centuries, but have not yet been fully resolved. Daikenchuto (TJ-100, DKT) is a traditional Japanese herbal medicine. Read More

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http://dx.doi.org/10.1186/s13063-017-2307-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697346PMC
November 2017
10 Reads

Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2).

Lancet 2018 01 8;391(10116):133-143. Epub 2017 Nov 8.

Inserm CIC 1415, Tours, France; Université de Tours, Tours, France; CHU Tours, Tours, France.

Background: Whether the route of early feeding affects outcomes of patients with severe critical illnesses is controversial. We hypothesised that outcomes were better with early first-line enteral nutrition than with early first-line parenteral nutrition.

Methods: In this randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2 trial) done at 44 French intensive-care units (ICUs), adults (18 years or older) receiving invasive mechanical ventilation and vasopressor support for shock were randomly assigned (1:1) to either parenteral nutrition or enteral nutrition, both targeting normocaloric goals (20-25 kcal/kg per day), within 24 h after intubation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01406736173214
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http://dx.doi.org/10.1016/S0140-6736(17)32146-3DOI Listing
January 2018
113 Reads

Broad Ligament Haematoma Following Normal Vaginal Delivery.

J Ayub Med Coll Abbottabad 2017 Jul-Sep;29(3):506-508

Department of Obstetrics & Gynaecology, Foundation University Medical College, Fauji Foundation Hospital, Rawalpindi, Pakistan.

A 37-year-old, patient presented in emergency with history of normal vaginal delivery followed by development of abdominal distention, vomiting, constipation for last 3 days. She was para 4 and had normal vaginal delivery by traditional birth attendant at peripheral hospital 3 days back. Imaging study revealed a heterogeneous complex mass, ascites, pleural effusion, air fluid levels with dilatation gut loops. Read More

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April 2019
2 Reads

Liquorice-Induced Severe Hypokalaemic Rhabdomyolysis with Acute Kidney Injury.

Ann Acad Med Singapore 2017 09;46(9):354-355

Department of Renal Medicine, Singapore General Hospital, Singapore.

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September 2017
4 Reads

Ogilvie's syndrome treated with an emergency laparotomy, right hemicolectomy and end ileostomy.

BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.

The Royal Stoke University Hospital, Stoke-on-Trent, UK.

Acute colonic pseudo-obstruction (ACPO), or Ogilvie's syndrome, is a rare clinical entity in which there is massive non-toxic colonic dilatation in the absence of a mechanically obstructing lesion. It is an important yet poorly recognised cause of surgical morbidity and mortality occurring typically in elderly patients with multiple comorbidities. ACPO can often be reversed conservatively with colonoscopic or nasogastric decompression. Read More

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http://dx.doi.org/10.1136/bcr-2017-220916DOI Listing
October 2017
24 Reads

A Rare Cause of Acute Colonic Pseudo-obstruction: Ogilvie's Syndrome Caused by Herpes Zoster.

J Neurogastroenterol Motil 2017 Oct;23(4):616-617

Department of Internal Medicine and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, Gyeonggi-do, Korea.

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http://dx.doi.org/10.5056/jnm17078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628995PMC
October 2017
9 Reads

Chronic intestinal pseudo-obstruction in a child with Treacher Collins syndrome.

Arch Pediatr 2017 Oct 15;24(10):1000-1004. Epub 2017 Sep 15.

Nutrition et gastroentérologie pédiatriques, hôpital Trousseau, AP-HP, 26, avenue du Dr-Netter, 75012 Paris, France. Electronic address:

Background: Treacher Collins syndrome (TCS) mainly presents with severe craniofacial developmental abnormalities characterized by a combination of bilateral downward-slanting palpebral fissures, colobomas of the lower eyelids, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. It is due to mutations in Treacher Collins syndrome 1 (TCOF1) (5q32-q33.1) and Polymerase RNA 1 polypeptides D and C (POLR1D [13q12. Read More

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http://dx.doi.org/10.1016/j.arcped.2017.07.004DOI Listing
October 2017
7 Reads