2,884 results match your criteria Ogilvie Syndrome


Pseudorapidity Dependence of Particle Production and Elliptic Flow in Asymmetric Nuclear Collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at sqrt[s_{NN}]=200  GeV.

Authors:
A Adare C Aidala N N Ajitanand Y Akiba M Alfred V Andrieux K Aoki N Apadula H Asano C Ayuso B Azmoun V Babintsev M Bai N S Bandara B Bannier K N Barish S Bathe A Bazilevsky M Beaumier S Beckman R Belmont A Berdnikov Y Berdnikov D S Blau M Boer J S Bok K Boyle M L Brooks J Bryslawskyj V Bumazhnov C Butler S Campbell V Canoa Roman R Cervantes C-H Chen C Y Chi M Chiu I J Choi J B Choi T Chujo Z Citron M Connors N Cronin M Csanád T Csörgő T W Danley A Datta M S Daugherity G David K DeBlasio K Dehmelt A Denisov A Deshpande E J Desmond A Dion P B Diss D Dixit J H Do A Drees K A Drees M Dumancic J M Durham A Durum T Elder A Enokizono H En'yo S Esumi B Fadem W Fan N Feege D E Fields M Finger M Finger S L Fokin J E Frantz A Franz A D Frawley Y Fukuda C Gal P Gallus P Garg H Ge F Giordano A Glenn Y Goto N Grau S V Greene M Grosse Perdekamp T Gunji H Guragain T Hachiya J S Haggerty K I Hahn H Hamagaki H F Hamilton S Y Han J Hanks S Hasegawa T O S Haseler K Hashimoto X He T K Hemmick J C Hill K Hill A Hodges R S Hollis K Homma B Hong T Hoshino N Hotvedt J Huang S Huang K Imai J Imrek M Inaba A Iordanova D Isenhower Y Ito D Ivanishchev B V Jacak M Jezghani Z Ji J Jia X Jiang B M Johnson V Jorjadze D Jouan D S Jumper S Kanda J H Kang D Kapukchyan S Karthas D Kawall A V Kazantsev J A Key V Khachatryan A Khanzadeev C Kim D J Kim E-J Kim G W Kim M Kim M H Kim B Kimelman D Kincses E Kistenev R Kitamura J Klatsky D Kleinjan P Kline T Koblesky B Komkov D Kotov S Kudo B Kurgyis K Kurita M Kurosawa Y Kwon R Lacey J G Lajoie E O Lallow A Lebedev S Lee S H Lee M J Leitch Y H Leung N A Lewis X Li X Li S H Lim L D Liu M X Liu V-R Loggins S Lökös K Lovasz D Lynch T Majoros Y I Makdisi M Makek M Malaev A Manion V I Manko E Mannel H Masuda M McCumber P L McGaughey D McGlinchey C McKinney A Meles M Mendoza W J Metzger A C Mignerey D E Mihalik A Milov D K Mishra J T Mitchell I Mitrankov G Mitsuka S Miyasaka S Mizuno A K Mohanty P Montuenga T Moon D P Morrison S I Morrow T V Moukhanova T Murakami J Murata A Mwai K Nagai K Nagashima T Nagashima J L Nagle M I Nagy I Nakagawa H Nakagomi K Nakano C Nattrass P K Netrakanti T Niida S Nishimura R Nishitani R Nouicer T Novák N Novitzky R Novotny A S Nyanin E O'Brien C A Ogilvie J D Orjuela Koop J D Osborn A Oskarsson G J Ottino K Ozawa R Pak V Pantuev V Papavassiliou J S Park S Park S F Pate M Patel J-C Peng W Peng D V Perepelitsa G D N Perera D Yu Peressounko C E PerezLara J Perry R Petti M Phipps C Pinkenburg R Pinson R P Pisani A Pun M L Purschke P V Radzevich J Rak B J Ramson I Ravinovich K F Read D Reynolds V Riabov Y Riabov D Richford T Rinn S D Rolnick M Rosati Z Rowan J G Rubin J Runchey A S Safonov B Sahlmueller N Saito T Sakaguchi H Sako V Samsonov M Sarsour K Sato S Sato B Schaefer B K Schmoll K Sedgwick R Seidl A Sen R Seto P Sett A Sexton D Sharma I Shein T-A Shibata K Shigaki M Shimomura T Shioya P Shukla A Sickles C L Silva D Silvermyr B K Singh C P Singh V Singh M J Skoby M Slunečka K L Smith M Snowball R A Soltz W E Sondheim S P Sorensen I V Sourikova P W Stankus M Stepanov S P Stoll T Sugitate A Sukhanov T Sumita J Sun Z Sun S Suzuki S Syed J Sziklai A Takeda A Taketani K Tanida M J Tannenbaum S Tarafdar A Taranenko G Tarnai R Tieulent A Timilsina T Todoroki M Tomášek C L Towell R Towell R S Towell I Tserruya Y Ueda B Ujvari H W van Hecke S Vazquez-Carson J Velkovska M Virius V Vrba N Vukman X R Wang Z Wang Y Watanabe Y S Watanabe F Wei A S White C P Wong C L Woody M Wysocki B Xia C Xu Q Xu L Xue S Yalcin Y L Yamaguchi H Yamamoto A Yanovich P Yin J H Yoo I Yoon H Yu I E Yushmanov W A Zajc A Zelenski S Zharko S Zhou L Zou

Phys Rev Lett 2018 Nov;121(22):222301

University of California-Riverside, Riverside, California 92521, USA.

Asymmetric nuclear collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at sqrt[s_{NN}]=200  GeV provide an excellent laboratory for understanding particle production, as well as exploring interactions among these particles after their initial creation in the collision. We present measurements of charged hadron production dN_{ch}/dη in all such collision systems over a broad pseudorapidity range and as a function of collision multiplicity. A simple wounded quark model is remarkably successful at describing the full data set. Read More

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November 2018

Simulating Fluorescence Detected Two-Dimensional Electronic Spectroscopy of Multi-Chromophoric Systems.

J Phys Chem B 2018 Dec 13. Epub 2018 Dec 13.

We present a theory for modeling fluorescence detected two-dimensional electronic spectroscopy of multichromophoric systems. The theory is tested by comparison of the predicted spectra of the light-harvesting complex LH2 with experimental data. A qualitative explanation of the strong cross-peaks as compared to conventional two-dimensional electronic spectra is given. Read More

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December 2018

Identifying Barriers to Treatment for Women With Cervical Dysplasia in Rural Northern British Columbia.

J Obstet Gynaecol Can 2018 Nov 29;40(11):1401-1408. Epub 2018 Jun 29.

Northern Medical Program, University of British Columbia, Prince George, BC; Women's Health Research Institute, Vancouver, BC; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC. Electronic address:

Objective: This study seeks to identify barriers to colposcopy examination faced by patients living in Northern BC to improve outcomes for women at risk of developing cervical cancer.

Methods: A retrospective chart review (n = 309) was conducted in the four colposcopy clinics in Northern BC to collect information regarding patients who were referred for colposcopy after abnormal cytology. Demographic factors associated with non-attendance were identified as barriers to accessing care. Read More

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November 2018
6 Reads

Continuous negative-to-positive tuning of thermal expansion achieved by controlled gas sorption in porous coordination frameworks.

Nat Commun 2018 11 19;9(1):4873. Epub 2018 Nov 19.

School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.

Control of the thermomechanical properties of functional materials is of great fundamental and technological significance, with the achievement of zero or negative thermal expansion behavior being a key goal for various applications. A dynamic, reversible mode of control is demonstrated for the first time in two Prussian blue derivative frameworks whose coefficients of thermal expansion are tuned continuously from negative to positive values by varying the concentration of adsorbed CO. A simple empirical model that captures site-specific guest contributions to the framework expansion is derived, and displays excellent agreement with the observed lattice behaviour. Read More

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November 2018

Ogilvie Syndrome with Caecal Perforation After Caesarean Section.

J Obstet Gynaecol India 2018 Dec 27;68(6):498-501. Epub 2018 Jan 27.

Aayush Hospitals, Vijayawada, Andhrapradesh India.

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December 2018

Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial.

Int J Cancer 2018 Nov 9. Epub 2018 Nov 9.

Wolfson Institute of Preventive Medicine Centre for Cancer Prevention, Queen Mary University, London, UK.

Human papillomavirus (HPV)-based cervical cancer screening requires triage of HPV positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. We conducted a blinded case-control study within the HPV FOCAL randomized cervical cancer screening trial of women aged 25-65 to examine whether baseline methylation testing using the S5 classifier provided triage performance similar to an algorithm relying on cytology and HPV genotyping. Groups were randomly selected from 257 women with known HPV/cytology results and pathology outcomes. Read More

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November 2018
5 Reads

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

J Med Chem 2018 Nov 19. Epub 2018 Nov 19.

Cancer Research UK Manchester Institute , The University of Manchester , Alderley Park , Maccelsfield SK10 4TG , U.K.

DNA damage repair enzymes are promising targets in the development of new therapeutic agents for a wide range of cancers and potentially other diseases. The enzyme poly(ADP-ribose) glycohydrolase (PARG) plays a pivotal role in the regulation of DNA repair mechanisms; however, the lack of potent drug-like inhibitors for use in cellular and in vivo models has limited the investigation of its potential as a novel therapeutic target. Using the crystal structure of human PARG in complex with the weakly active and cytotoxic anthraquinone 8a, novel quinazolinedione sulfonamides PARG inhibitors have been identified by means of structure-based virtual screening and library design. Read More

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November 2018
5 Reads

Effects of the use of silver-coated urinary catheters on the incidence of catheter-associated bacteriuria and urinary tract infection in dogs.

J Am Vet Med Assoc 2018 Nov;253(10):1289-1293

OBJECTIVE To determine the effects of silver-coated versus standard silicone urinary catheters on the incidence of catheter-associated bacteriuria (CAB) and catheter-associated urinary tract infection (CAUTI) in dogs. DESIGN Randomized controlled clinical trial. ANIMALS 36 dogs requiring urinary bladder catheterization for ≥ 24 hours. Read More

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November 2018
6 Reads

Wilkie or Ogilvie?

Authors:
Avi Ohry

Spinal Cord Ser Cases 2018 27;4:95. Epub 2018 Oct 27.

Reuth Medical Center, Tel Aviv & Professor Emeritus of Rehabilitation Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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October 2018
1 Read

Age at last screening and remaining lifetime risk of cervical cancer in older, unvaccinated, HPV-negative women: a modelling study.

Lancet Oncol 2018 Dec 1;19(12):1569-1578. Epub 2018 Nov 1.

Division of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada.

Background: There is a paucity of empirical evidence to inform the age at which to stop cervical cancer screening. The recommended age to stop screening generally varies between age 50-70 years worldwide. However, cervical cancer incidence and mortality remain high in older women. Read More

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December 2018
1 Read

Care needed in interpretation of chromosome rearrangements.

Reprod Biomed Online 2018 Nov 6;37(5):651. Epub 2018 Oct 6.

Assisted Conception Unit, Guy's and St Thomas' NHS Trust, London, UK.

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November 2018

Characterization of Vibrational Coherence in Monomeric Bacteriochlorophyll a by Two-Dimensional Electronic Spectroscopy.

J Phys Chem Lett 2018 Nov 7;9(22):6631-6637. Epub 2018 Nov 7.

Department of Physics , University of Michigan , Ann Arbor , Michigan 48108 , United States.

Bacteriochlorophyll a (BChla) is the most abundant pigment found in the Bacterial Reaction Center (BRC) and light-harvesting proteins of photosynthetic purple and green bacteria. Recent two-dimensional electronic spectroscopy (2DES) studies of photosynthetic pigment-protein complexes including the BRC and the Fenna-Matthews-Olson (FMO) complex have shown oscillatory signals, or coherences, whose physical origin has been hotly debated. To better understand the observations of coherence in larger photosynthetic systems, it is important to carefully characterize the spectroscopic signatures of the monomeric pigments. Read More

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November 2018
10 Reads

Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction.

J Intensive Care Med 2018 Oct 29:885066618809010. Epub 2018 Oct 29.

1 Department of Pharmacotherapy and Pharmacy Services, University Health System, San Antonio, TX, USA.

Purpose:: To compare clinical response of intermittent bolus versus continuous infusion neostigmine for acute colonic pseudo-obstruction (ACPO). Acute colonic pseudo-obstruction occurs due to reduced colonic parasympathetic activity. Neostigmine is an acetylcholinesterase inhibitor that increases frequency of smooth muscle contraction by increasing acetylcholine at autonomic nervous system synapses. Read More

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October 2018
8 Reads

Characteristics of the environment and physical activity in midlife: Findings from UK Biobank.

Prev Med 2018 Oct 25;118:150-158. Epub 2018 Oct 25.

MRC Epidemiology Unit & UKCRC Centre for Diet and Activity Research (CEDAR), University of Cambridge, School of Clinical Medicine, Box 285, Cambridge Biomedical Campus, Cambridge, Cambridgeshire CB2 0QQ, UK. Electronic address:

Characteristics of the environment influence health and may promote physical activity. We explored the associations between neighborhood environmental characteristics grouped within five facets (spaces for physical activity, walkability, disturbance, natural environment, and the sociodemographic environment) and objective ('recorded') and self-reported ('reported') physical activity in adults from UK Biobank. Recorded activity was assessed using wrist-worn accelerometers (2013-2015, n = 65,967) and time spent in moderate-to-vigorous physical activity (MVPA), walking, and walking for pleasure was self-reported (2006-2010, n = 337,822). Read More

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October 2018
3 Reads

Acute Care Surgery Model and Outcomes in Emergency General Surgery.

J Am Coll Surg 2018 Oct 22. Epub 2018 Oct 22.

Department of Surgery, University of Michigan, Ann Arbor, MI.

Background: Annually, more than 2 million patients are admitted with emergency general surgery (EGS) conditions. Emergency general surgery cases comprise 11% of all general surgery operations, yet account for 47% of mortalities and 28% of complications. Using the statewide general surgery Michigan Surgical Quality Collaborative (MSQC) data, we previously confirmed that wide variations in EGS outcomes were unrelated to case volume/complexity. Read More

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October 2018
5 Reads

Differences in colorectal cancer screening rates across income strata by levels of urbanization: results from the Canadian Community Health Survey (2013/2014).

Can J Public Health 2018 Oct 23. Epub 2018 Oct 23.

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: Canadian colorectal cancer screening rates differ across income strata. In the United States, disparities across income strata worsen in rural areas. In Canada, differences in screening across income strata have not been explored by levels of urbanization. Read More

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October 2018

Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study.

Lancet HIV 2018 Nov 17;5(11):e629-e637. Epub 2018 Oct 17.

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Background: HIV pre-exposure prophylaxis (PrEP) is highly effective in men who have sex with men (MSM) at the individual level, but data on population-level impact are lacking. We examined whether rapid, targeted, and high-coverage roll-out of PrEP in an MSM epidemic would reduce HIV incidence in the cohort prescribed PrEP and state-wide in Australia's most populous state, New South Wales.

Methods: The Expanded PrEP Implementation in Communities-New South Wales (EPIC-NSW) study is an implementation cohort study of daily co-formulated tenofovir disoproxil fumarate and emtricitabine as HIV PrEP. Read More

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November 2018
7 Reads

Ogilvie syndrome presenting with septic shock.

Turk J Pediatr 2018 ;60(2):225-227

Division of Pediatric Intensive Care Unit, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Özsoylu S, Akyıldız BN, Dursun A. Ogilvie syndrome presenting with septic shock. Turk J Pediatr 2018; 60: 225-227. Read More

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January 2018
10 Reads

Embryonic Stem Cell Models of Human Brain Tumors.

Methods Mol Biol 2019 ;1869:127-142

Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.

Utilization of human embryonic stem cells (hESCs) as a model system to study highly malignant pediatric cancers has led to significant insight into the molecular mechanisms governing tumor progression and has revealed novel therapeutic targets for these devastating diseases. Here, we describe a method for generating heterogeneous populations of neural precursors from both normal and neoplastic hESCs and the subsequent injection of neoplastic human embryonic neural cells (hENs) into intracerebellar or intracranial xenograft models. Histopathologically, neural tumors derived from neoplastic hENs exhibit features similar to more aggressive medulloblastoma, the most common malignant primary pediatric brain tumor. Read More

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January 2019
5 Reads

Population-level sexual behaviours in adolescent girls before and after introduction of the human papillomavirus vaccine (2003-2013).

CMAJ 2018 Oct;190(41):E1221-E1226

School of Population and Public Health (Ogilvie, Phan, Pedersen), Faculty of Medicine; School of Nursing (Saewyc), The University of British Columbia; Women's Health Research Institute (Ogilvie, Phan, Pedersen), BC Women's Hospital; Vaccine Evaluation Center (Dobson), BC Children's Hospital Research Centre; BC Centre for Disease Control (Naus), Vancouver, BC.

Background: The human papillomavirus (HPV) vaccine is delivered widely through school-based immunization programs. Some groups have expressed concern that HPV vaccination programs will result in an increase in sexual risk-taking behaviours among adolescents. We aimed to evaluate population-level changes in sexual behaviours before and after implementation of the school-based HPV vaccination program in British Columbia. Read More

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October 2018
6 Reads

Effects of controlled ovarian stimulation on toxicity of TAC chemotherapy in early breast cancer patients.

Cancer Manag Res 2018 26;10:3931-3935. Epub 2018 Sep 26.

Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands,

Background: Oocyte and embryo cryopreservation, using controlled ovarian stimulation (COS), are common fertility preservation methodologies in breast cancer patients receiving gonadotoxic neo (adjuvant) chemotherapy (CT). The effects of COS and peak estradiol levels on CT-induced side effects are unknown.

Patients And Methods: Eighteen patients with stage II and III breast cancer underwent oocyte or embryo cryopreservation at Leiden University Medical Center before receiving docetaxel, adriamycin, and cyclophosphamide (TAC) CT (COS group). Read More

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September 2018
6 Reads

Spatially-resolved fluorescence-detected two-dimensional electronic spectroscopy probes varying excitonic structure in photosynthetic bacteria.

Nat Commun 2018 10 11;9(1):4219. Epub 2018 Oct 11.

Department of Physics, University of Michigan, Ann Arbor, Michigan, 48109, USA.

Conventional implementations of two-dimensional electronic spectroscopy typically spatially average over ~10 chromophores spread over ~10 micron square area, limiting their ability to characterize spatially heterogeneous samples. Here we present a variation of two-dimensional electronic spectroscopy that is capable of mapping spatially varying differences in excitonic structure, with sensitivity orders of magnitude better than conventional spatially-averaged electronic spectroscopies. The approach performs fluorescence-detection-based fully collinear two-dimensional electronic spectroscopy in a microscope, combining femtosecond time-resolution, sub-micron spatial resolution, and the sensitivity of fluorescence detection. Read More

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October 2018
1 Read
10.742 Impact Factor

Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill.

Nutr Clin Pract 2018 Oct 7. Epub 2018 Oct 7.

Department of Neuro-Gastroenterology, University College London, London, UK.

Gastrointestinal dysmotility causes delayed gastric emptying, enteral feed intolerance, and functional obstruction of the small and large intestine, the latter functional obstructions being frequently termed ileus and Ogilvie syndrome, respectively. In addition to meticulous supportive care, drug therapy may be appropriate in certain situations. There is, however, considerable variation among individuals regarding what gastric residual volume identifies gastric dysmotility and would encourage use of a promotility drug. Read More

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October 2018
5 Reads

Changes in workplace car parking and commute mode: a natural experimental study.

J Epidemiol Community Health 2019 Jan 3;73(1):42-49. Epub 2018 Oct 3.

MRC Epidemiology Unit, Centre for Diet and Activity Research (CEDAR), University of Cambridge School of Clinical Medicine, Cambridge, UK.

Background: The use of private motor vehicles places a considerable burden on public health. Changes in workplace car parking policies may be effective in shifting behaviour. We use a natural experimental design to assess whether changes in policy were associated with differences in commute mode. Read More

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January 2019

Surgical management of benign phyllodes tumours of the breast: Is wide local excision really necessary?

Can J Surg 2018 12;61(6):17617

From the Department of Surgery, Foothills Medical Centre, the University of Calgary, Calgary, Alta. (Qian, Quan, Bouchard-Fortier); and the Department of Anatomic Pathology, Foothills Medical Centre, University of Calgary, Calgary, Alta. (Ogilvie).

Summary: Current guidelines recommending wide local excision (≥ 1 cm margin) for all breast phyllodes tumours regardless of classification are based on retrospective data. Benign phyllodes tumours of the breast are not aggressive. They are often indistinguishable from fibroadenomas on core biopsy and are diagnosed only after excisions without attention to margins. Read More

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December 2018

Understanding Men's Perceptions of Human Papillomavirus and Cervical Cancer Screening in Kampala, Uganda.

J Glob Oncol 2018 Sep(4):1-9

Erin Moses, Emily C. Wagner, Deborah M. Money, and Gina S. Ogilvie, Women's Health Research Institute, BC Women's Hospital + Health Centre; Heather N. Pedersen, University of British Columbia, Vancouver, British Columbia, Canada; and Musa Sekikubo, Deborah M. Money, Gina S. Ogilvie, and Sheona M. Mitchell-Foster, Makerere University, Kampala, Uganda.

Purpose: This preliminary study explores Ugandan men's knowledge and attitudes about human papillomavirus (HPV), cervical cancer, and screening.

Methods: A local physician led an education session about cervical cancer for 62 men in Kisenyi, Kampala in Uganda. Trained nurse midwives administered surveys to assess knowledge and attitudes before and after the education session. Read More

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September 2018
1 Read

Comparative performance of human papillomavirus messenger RNA versus DNA screening tests at baseline and 48 months in the HPV FOCAL trial.

J Clin Virol 2018 Nov 10;108:32-37. Epub 2018 Sep 10.

BC Centre for Disease Control, Vancouver, BC, Canada; Lower Mainland Pathology & Laboratory Medicine, Provincial Health Services Authority, Vancouver, BC, Canada; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Background: HPV FOCAL is a randomized trial comparing high-risk HPV [Hybrid Capture 2 (HC2)] vs. liquid-based cytology (LBC) for primary cervical screening.

Objective: The present study objective was to compare Aptima HPV (AHPV) and HC2 assay performance at the intervention arm baseline and 48 mo. Read More

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November 2018
15 Reads

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.

N Engl J Med 2018 10 16;379(16):1509-1518. Epub 2018 Sep 16.

From the Department of Epidemiology and Preventive Medicine, Monash University (J.J.M., R.W., R.L.W., A.M.T., M.R.N., C.M.R., J.E.L., E.S., S.M.F., S.G.O., R.E.T., C.I.J., J.R., E.M.W., S.E.M.), Baker Heart and Diabetes Institute (C.I.J.), the Department of Cardiology, St. Vincent's Hospital (M.J.), and the Department of Clinical Neurosciences, Central Clinical School, Monash University and Alfred Hospital (G.C.), Melbourne, and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville (G.A.D.), VIC, Menzies Institute for Medical Research, University of Tasmania, Hobart (M.R.N.), the School of Public Health, Curtin University (C.M.R.), and the School of Medicine, Royal Perth Hospital, University of Western Australia (L.J.B.), Perth, the College of Medicine, Biology and Environment, Australian National University, Canberra, ACT (W.P.A.), and the Discipline of General Practice, University of Adelaide, Adelaide, SA (N.S.) - all in Australia; the Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare (B.K., R.G., A.M.M.), HealthPartners Institute (K.L.M.), and the Division of Geriatrics, Department of Medicine, Hennepin Healthcare and the University of Minnesota (A.M.M.), Minneapolis, and the School of Nursing, Minnesota State University, Mankato (D.B.) - all in Minnesota; the Department of Family Medicine and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago (R.C.S.); Sticht Center on Aging and Alzheimer's Prevention, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (J.D.W.); the Department of Pharmacy Practice and Science, College of Pharmacy and Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City (M.E.E.); the Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, MD (B.R.); the Department of Cardiovascular Medicine, Vascular Medicine Section, Cleveland Clinic, Cleveland (M.M.); the Center for Primary Care and Prevention, Brown University, Providence, RI (C.B.E.); and the University of Tennessee Health Science Center, Memphis (S.S.).

Background: Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.

Methods: From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or disability. Read More

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October 2018
16 Reads
1 Citation
55.870 Impact Factor

Effect of Aspirin on Disability-free Survival in the Healthy Elderly.

N Engl J Med 2018 10 16;379(16):1499-1508. Epub 2018 Sep 16.

From the Department of Epidemiology and Preventive Medicine, Monash University (J.J.M., R.L.W., M.R.N., C.M.R., R.W., E.S., J.E.L., A.M.T., S.M.F., S.G.O., R.E.T., C.I.J., J.R.), the Walter and Eliza Hall Institute of Medical Research (P.G.), and the Baker Heart and Diabetes Institute (C.I.J.), Melbourne, and the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville (G.A.D.), VIC, Menzies Institute for Medical Research, University of Tasmania, Hobart (M.R.N.), the School of Public Health, Curtin University (C.M.R.), and the School of Medicine, Royal Perth Hospital, University of Western Australia (L.J.B.), Perth, the College of Medicine, Biology, and Environment, Australian National University, Canberra, ACT (W.P.A.), and Discipline of General Practice, University of Adelaide, Adelaide, SA (N.S.) - all in Australia; Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare (B.K., R.G., A.M.M.), HealthPartners Institute (K.L.M.), and the Division of Geriatrics, Department of Medicine, University of Minnesota (A.M.M.) - all in Minneapolis; the Department of Family Medicine and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago (R.C.S.); the Center for Aging and Population Health, University of Pittsburgh, Pittsburgh (A.B.N.); Sticht Center on Aging and Alzheimer's Prevention, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (J.D.W.); the Department of Pharmacy Practice and Science, College of Pharmacy, and the Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City (M.E.E.); and the Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, MD (B.R.).

Background: Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear.

Methods: From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or physical disability. Read More

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October 2018
10 Reads
55.870 Impact Factor

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.

N Engl J Med 2018 10 16;379(16):1519-1528. Epub 2018 Sep 16.

From the Department of Epidemiology and Preventive Medicine, Monash University (J.J.M., M.R.N., R.L.W., J.E.L., R.W., C.M.R., E.S., J.R., A.M.T., S.M.F., S.G.O., R.E.T., C.I.J.), Walter and Eliza Hall Institute of Medical Research (P.G.), and Baker Heart and Diabetes Institute (C.I.J.), Melbourne, and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville (G.A.D.), VIC, Menzies Institute for Medical Research, University of Tasmania, Hobart (M.R.N.), the School of Public Health, Curtin University (C.M.R.), and the School of Medicine, Royal Perth Hospital, University of Western Australia (L.J.B.), Perth, College of Medicine, Biology, and Environment, Australian National University, Canberra, ACT (W.P.A.), and Discipline of General Practice, University of Adelaide, Adelaide, SA (N.S.) - all in Australia; Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute (B.K., R.G., A.M.M.), and the Division of Geriatrics, Department of Medicine (A.M.M.), Hennepin Healthcare, HealthPartners Institute (K.L.M.), and the University of Minnesota (A.M.M.) - all in Minneapolis; the Department of Family Medicine and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago (R.C.S.); the Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh (D.G.I., A.B.N.); Sticht Center on Aging and Alzheimer's Prevention, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (J.D.W.); the Department of Pharmacy Practice and Science, College of Pharmacy and Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City (M.E.E.); and the Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, MD (B.R.).

Background: In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo.

Methods: From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or disability. Read More

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October 2018
8 Reads
55.870 Impact Factor

Effect of opioid-substitution therapy and mental health counseling on HIV risk among hepatitis C-infected individuals.

Clin Epidemiol 2018 31;10:1127-1145. Epub 2018 Aug 31.

School of Population and Public Health, University of British Columbia, Vancouver, BC,

Background: Understanding differences in HIV incidence among people living with hepatitis C virus (HCV) can help inform strategies to prevent HIV infection. We estimated the time to HIV diagnosis among HCV-positive individuals and evaluated factors that could affect HIV-infection risk in this population.

Patients And Methods: The British Columbia Hepatitis Testers Cohort includes all BC residents (~1. Read More

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August 2018
15 Reads

The Effect of Cervico-lumbar Coupling on Spinal Reflexes during Cycling after Incomplete Spinal Cord Injury.

J Neurophysiol 2018 Sep 12. Epub 2018 Sep 12.

Division of Physical Medicine & Rehabilitation, Department of Medicine, University of Alberta, Canada.

Spinal networks in the cervical and lumbar cord are actively coupled during locomotion to coordinate arm and leg activity. The goals of this project were to investigate the intersegmental cervico-lumbar connectivity during cycling after incomplete spinal cord injury (iSCI), and assess the effect of rehabilitation training on improving reflex modulation mediated by cervico-lumbar pathways. Two studies were conducted. Read More

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September 2018
1 Read

A foreign body in inguinal canal: A case report.

Int J Surg Case Rep 2018 19;51:221-223. Epub 2018 Aug 19.

College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Introduction: Inguinal bladder hernias are rare incidents accounting for 1-3% of all inguinal hernia. Most of those cases are discovered intraoperatively accounting for the high incidence of bladder injuries during the repair. Symptoms can be variable depending on the size of the herniated bladder. Read More

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August 2018
2 Reads

Minimal Access Surgery for Spinal Metastases: Prospective Evaluation of a Treatment Algorithm Using Patient-Reported Outcomes.

World Neurosurg 2018 Dec 4;120:e889-e901. Epub 2018 Sep 4.

Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA. Electronic address:

Background: Minimal access surgery (MAS) allows for an early return to systemic and radiation therapy in patients with cancer, leading to its increasing usage in the treatment of spinal metastases. Systematic examination of surgical indications resulted in the development of an algorithm for implementation of MAS in the treatment of spinal metastases. The objective of the present study was to evaluate a spine tumor MAS treatment algorithm using patient-reported outcomes for patients with cancer undergoing treatment of spinal metastases. Read More

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December 2018
3 Reads

Associations between polysomnography and actigraphy-based sleep indices and glycemic control among those with and without type 2 diabetes: the Multi-Ethnic Study of Atherosclerosis.

Sleep 2018 Nov;41(11)

Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Study Objectives: To examine the associations of sleep measures with hemoglobin A1c (HbA1c) among individuals with and without type 2 diabetes.

Methods: Data were from 2049 Multi-Ethnic Study of Atherosclerosis participants taking part in a sleep ancillary study. Cross-sectional linear regression models examined associations of actigraphy estimates of sleep (sleep duration, variability, and maintenance efficiency) and polysomnography measures (obstructive sleep apnea [OSA] and hypoxemia) with HbA1c, stratified by diabetes status. Read More

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November 2018

Ogilvie syndrome following pediatric scoliosis surgery.

J Musculoskelet Neuronal Interact 2018 Sep;18(3):399-401

University of Calgary Cumming School of Medicine, Calgary, AB, Canada.

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September 2018
1 Read

Electronic Interactions in the Bacterial Reaction Center Revealed by Two-Color 2D Electronic Spectroscopy.

J Phys Chem Lett 2018 Sep 30;9(18):5219-5225. Epub 2018 Aug 30.

Department of Physics , University of Michigan , Ann Arbor , Michigan 49109-1040 , United States.

The bacterial reaction center (BRC) serves as an important model system for understanding the charge separation processes in photosynthesis. Knowledge of the electronic structure of the BRC is critical for understanding its charge separation mechanism. While it is well-accepted that the "special pair" pigments are strongly coupled, the degree of coupling among other BRC pigments has been thought to be relatively weak. Read More

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September 2018
2 Reads

Strongly coupled bacteriochlorin dyad studied using phase-modulated fluorescence-detected two-dimensional electronic spectroscopy.

Opt Express 2018 Aug;26(17):22327-22341

Fluorescence-detected two-dimensional electronic spectroscopy (F-2DES) projects the third-order non-linear polarization in a system as an excited electronic state population which is incoherently detected as fluorescence. Multiple variants of F-2DES have been developed. Here, we report phase-modulated F-2DES measurements on a strongly coupled symmetric bacteriochlorin dyad, a relevant 'toy' model for photosynthetic energy and charge transfer. Read More

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August 2018
3.490 Impact Factor

The Epidemiology of Sleep and Diabetes.

Curr Diab Rep 2018 Aug 17;18(10):82. Epub 2018 Aug 17.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 3471 Fifth Avenue, Suite 1216, Kaufmann Medical Building, Pittsburgh, PA, 15213, USA.

Purpose Of Review: To provide an overview of the mechanistic and epidemiologic evidence linking sleep-related exposures, such as short sleep duration, obstructive sleep apnea, shift work, and insomnia, with type 2 diabetes risk in adults.

Recent Findings: Both poor sleep habits and sleep disorders are highly prevalent among adults with type 2 diabetes. In observational studies, short sleep duration, obstructive sleep apnea, shift work, and insomnia are all associated with higher risk of incident type 2 diabetes and may predict worse outcomes in those with existing diabetes. Read More

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August 2018
1 Read

Experimental demonstration of ray-rotation sheets.

J Opt Soc Am A Opt Image Sci Vis 2018 Jul;35(7):1160-1164

We have built microstructured sheets that rotate, on transmission, the direction of light rays by an arbitrary, but fixed, angle around the sheet normal. These ray-rotation sheets comprise two pairs of confocal lenticular arrays. In addition to rotating the direction of transmitted light rays, our sheets also offset ray position sideways on the scale of the diameter of the lenticules. Read More

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July 2018
7 Reads

Phase 3 Study of OnabotulinumtoxinA Distributed Between Frontalis, Glabellar Complex, and Lateral Canthal Areas for Treatment of Upper Facial Lines.

Dermatol Surg 2018 Nov;44(11):1437-1448

Allergan plc, Irvine, California.

Background: Although commonly practiced, simultaneous onabotulinumtoxinA injections to multiple facial areas have not been investigated in prospective studies.

Objective: Evaluate safety and efficacy of onabotulinumtoxinA for treatment of forehead lines (FHL) distributed between the frontalis (20 U) and glabellar complex (20 U), with or without simultaneous lateral canthal areas (crow's feet lines [CFL], 24 U) treatment.

Methods: Subjects with moderate to severe FHL were randomized (2:2:1) to onabotulinumtoxinA 40 U, onabotulinumtoxinA 64 U, or placebo. Read More

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November 2018
2 Reads

Exploring the mechanisms of the racial disparity in drowsy driving.

Sleep Health 2018 Aug 24;4(4):331-338. Epub 2018 Apr 24.

Vascular Medicine Institute, University of Pittsburgh School of Medicine; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine.

Objective: Drowsy driving is a significant cause of traffic accidents and fatalities. Although previous reports have shown an association between race and drowsy driving, the reasons for this disparity remain unclear.

Study Design: A cross-sectional analysis of responses from 193,776 White, Black, and Hispanic adults participating in the US Behavioral Risk Factor Surveillance System from 2009 to 2012 who answered a question about drowsy driving. Read More

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August 2018
10 Reads

Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report.

A A Pract 2018 Jul 16. Epub 2018 Jul 16.

Vanderbilt University School of Medicine/Vanderbilt University Medical Center, Nashville, Tennessee.

Pain management with opioids is often limited by medication side effects. One of the most common and distressing side effects is opioid-induced constipation (OIC), a syndrome that is now getting significant national attention. We report the case of an opioid-dependent 56-year-old man who underwent lumbar decompression for spinal stenosis. Read More

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July 2018
4 Reads

Effect of human papillomavirus vaccination on sexual behaviour among young females.

Can Fam Physician 2018 Jul;64(7):509-513

At the time of implementation of human papillomavirus (HPV) vaccine immunization programs, concerns were raised by parents, clinicians, and public health professionals about HPV vaccination possibly leading to riskier sexual health choices among young females. If HPV vaccination influences sexual behaviour among vaccinated females, this might influence the effect of HPV vaccination programs. What is known about the effects of the HPV vaccination program on sexual behaviour among young females? Human papillomavirus vaccination has not been associated with increased sexual risk behaviour among young females. Read More

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July 2018
6 Reads

The impact of booster seat use on child injury and mortality: Systematic review and meta-analysis of observational studies of booster seat effectiveness.

Accid Anal Prev 2018 Oct 5;119:50-57. Epub 2018 Jul 5.

Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To determine through systematic review and meta-analysis of observational studies if booster seats, compared to seatbelts alone, reduce injury and mortality from motor vehicle collisions among child passengers four to eight years of age.

Methods: A comprehensive search of several data sources (including Medline, Embase, and PsycINFO) was conducted from inception to December 2016, to retrieve relevant publications in any language and from any geographic region. Data extraction was completed by two independent reviewers, capturing: study details, population characteristics, exposure (booster seat compared to seat belt use), outcomes (injury and fatality), and all associations reported between the exposure and outcomes. Read More

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October 2018

Captive individuals of endangered Philippine raptors maintain native feather mites (Acariformes: Pterolichoidea) species.

Int J Parasitol Parasites Wildl 2018 Aug 17;7(2):116-133. Epub 2018 Mar 17.

Johann Wolfgang Goethe-University Frankfurt, Buchmann Institute for Molecular Life Sciences and Institute of Biophysical Chemistry, Max-von-Laue-Str. 15, D-60438 Frankfurt, Germany.

Endangered species of hosts are coupled with endangered species of parasites, which share the risk of co-extinction. Conservation efforts sometimes include breeding of rare species in captivity. Data on parasites of captive populations of endangered species is scarce and the ability of small numbers of captive host individuals to support the biodiversity of native parasites is limited. Read More

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August 2018
7 Reads

Relating Bryophyte Assemblages to a Remotely Sensed Depth-to-Water Index in Boreal Forests.

Front Plant Sci 2018 25;9:858. Epub 2018 Jun 25.

Department of Renewable Resources, University of Alberta, Edmonton, AB, Canada.

Given the habitat moisture (air humidity or soil moisture) preferences of many forest bryophytes, we explored whether the depth-to-water (DTW) index, derived from remotely sensed Light Detection and Ranging (LiDAR) data, was related to fine-scale patterns of spatial variation in bryophyte abundance, diversity, and composition. The goal was to assess the utility of the topographic DTW index as a tool to decipher trends in bryophyte assemblages along a site wetness gradient in the boreal mixedwood forest. Discrete Airborne Laser Scanning (ALS) data were acquired over the entire Ecosystem Management Emulating Natural Disturbance (EMEND) experimental site located in northwestern Alberta, Canada (56° 46' 13″ N, 118° 22' 28″ W), based on which we calculated a mathematical index of approximate depth to water at or below the soil surface at 1 m resolution using the Wet-Areas Mapping model. Read More

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Can Preoperative Magnetic Resonance Imaging Predict Intraoperative Autograft Size for Anterior Cruciate Ligament Reconstruction? A Systematic Review.

J Knee Surg 2018 Jul 6. Epub 2018 Jul 6.

Department of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada.

This systematic review explored the utility of preoperative magnetic resonance imaging (MRI) as a tool for predicting intraoperative graft size for anterior cruciate ligament (ACL) reconstruction. Three databases (EMBASE, PubMed, and MEDLINE) were searched in November 2017 for English-language studies of all levels of evidence that aimed to correlate preoperative MRI measurements of common primary ACL autograft sources to intraoperative measurements of the harvested graft. Two reviewers applied predetermined inclusion/exclusion criteria to independently complete title, abstract, and full-text review of eligible studies. Read More

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