1,355 results match your criteria Ogilvie Syndrome

Recurrent abdominal distention, colonic ulcer is a cause or a consequence?

Gastroenterology 2022 Jun 15. Epub 2022 Jun 15.

Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. Electronic address:

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[Ogilvie´s syndrome as a rare complication of lumbar stenosis surgery: report of two cases and literature review].

Pan Afr Med J 2022 4;42. Epub 2022 May 4.

Service de Neurochirurgie, Centre Hospitalier Universitaire, Guadeloupe, France.

Ogilvie´s syndrome is an acute colonic pseudo-obstruction, characterized by massive colonic distension in the absence of mechanical cause. It is a very rare pathology after spinal surgery. We report two cases in the neurosurgery department of the University Hospital of Guadeloupe. Read More

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[A case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) complicated by chronic intestinal pseudo-obstruction].

Rinsho Shinkeigaku 2022 Jun 28;62(6):464-468. Epub 2022 May 28.

Department of Neurology, School of Medicine, Sapporo Medical University.

A 42-year-old woman presented at our hospital with acute paraphasia and word finding difficulty. She was not paralyzed or ataxic. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) was diagnosed based on brain MRI finding of edematous lesions in bilateral temporal lobe cortexes that did not match the vascular territory, elevated lactate and pyruvate levels in blood and cerebrospinal fluid, and the presence of a mtDNA 3243A>G mutation. Read More

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Ogilvie's syndrome after an emergency caesarean section: A case report.

Case Rep Womens Health 2022 Apr 3;34:e00392. Epub 2022 Feb 3.

Obstetrics and Gynaecology, Liverpool Hospital, 75 Elizabeth Street Liverpool, NSW, 2170, Australia.

Ogilvie's syndrome, or acute colonic pseudo-obstruction, is a rare presentation occasionally observed postpartum, particularly following caesarean sections. Challenges in diagnosis often lead to delays in initiation of treatment, which significantly increases complications, including caecal ischaemia, perforation, sepsis and death. This case report describes the development of Ogilvie's syndrome within 24 h of an emergency caesarean section which was promptly recognised and confirmed by computed tomography, which demonstrated caecal dilatation of 9. Read More

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In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions.

Pharmacol Res Perspect 2022 06;10(3):e00959

Zogenix, Inc, Emeryville, California, USA.

Studies support the safety and efficacy of fenfluramine (FFA) as an antiseizure medication (ASM) in Dravet syndrome, Lennox-Gastaut syndrome, or CDKL5 deficiency disorder, all pharmacoresistant developmental and epileptic encephalopathies. However, drug-drug interactions with FFA in multi-ASM regimens have not been fully investigated. We characterized the perpetrator potential of FFA and its active metabolite, norfenfluramine (nFFA), in vitro by assessing cytochrome P450 (CYP450) inhibition in human liver microsomes, CYP450 induction in cultured human hepatocytes, and drug transporter inhibition potential in permeability or cellular uptake assays. Read More

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In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions.

Pharmacol Res Perspect 2022 06;10(3):e00958

Zogenix, Inc, Emeryville, California, USA.

Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood-onset developmental and epileptic encephalopathies (e.g., Dravet syndrome). Read More

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CD3 T-Lymphocytic Coeliac-Mesenteric Ganglioneuritis Associated with Colonic Torsion and Inflammatory Bowel Disease in an Arabian Broodmare.

J Comp Pathol 2022 Jun 9;194:1-6. Epub 2022 Apr 9.

Equine Veterinary Medical Center, Qatar Foundation, Doha, Qatar. Electronic address:

A 5-year-old Arabian broodmare with acute colic was diagnosed with lymphocytic ganglioneuritis of the coeliac-mesenteric ganglia and lymphocytic‒plasmacytic enterocolitis resembling inflammatory bowel disease. No significant pathogens were identified by aerobic culture or histopathological examination. The ganglia were multifocally infiltrated with small lymphocytes that were immunopositive for CD3 and negative for CD20 and CD79a antigens, indicating CD3 T-lymphocyte-mediated coeliac-mesenteric ganglioneuritis. Read More

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A Rare Case of a Failed AngioVac Procedure Used to Debride Tricuspid Vegetation Complicated by Ogilvie Syndrome.

Cureus 2022 Mar 28;14(3):e23584. Epub 2022 Mar 28.

Cardiology, Virtua, Camden, USA.

Ogilvie syndrome is a rare disorder characterized by dilatation of part or all of the colon and rectum without intrinsic or extrinsic mechanical obstruction. Its etiology is likely multifactorial with high mortality if left untreated. Here, we report for the first time a case of Ogilvie syndrome secondary to the AngioVac procedure. Read More

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Acute Pancreatitis with Colonic Pseudo-obstruction in a Patient with COVID-19.

Case Rep Gastroenterol 2022 Jan-Apr;16(1):97-102. Epub 2022 Mar 1.

Department of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.

Angiotensin-converting enzyme 2 receptor, the receptor used by severe acute respiratory syndrome coronavirus-2 (COVID-19) to infect cells, is found not only on respiratory epithelium but also in the small bowel, large bowel, and pancreas. There have been rare reports of acute pancreatitis (AP) in COVID-19 patients without an obvious etiology other than the underlying viral syndrome. We present a patient who was admitted with COVID-19 and developed AP and colonic pseudo-obstruction. Read More

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Abdominal Compartment Syndrome with Extrinsic Compression of the Abdominal Aorta in Acute Colonic Pseudo-Obstruction.

J Gastrointest Surg 2022 Mar 23. Epub 2022 Mar 23.

Department of Vascular and Endovascular Surgery, Hospices Civils de Lyon, Hôpital Louis Pradel, F-69677, Bron Cedex, France.

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Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response.

Microbiol Spectr 2022 04 10;10(2):e0140521. Epub 2022 Mar 10.

British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.

We investigate the diagnostic accuracy and predictive value of finger prick capillary dried blood spot (DBS) samples tested by a quantitative multiplex anti-immunoglobulin G (IgG) assay to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies after infection or vaccination. This cross-sectional study involved participants ( = 6,841) from several serological surveys conducted in nonhospitalized children and adults throughout 2020 and 2021 in British Columbia (BC), Canada. Analysis used paired DBS and serum samples from a subset of participants ( = 642) prior to vaccination to establish signal thresholds and calculate diagnostic accuracy by logistic regression. Read More

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Fatal Ogilvie's syndrome after hip surgery and review of the literature.

Forensic Sci Med Pathol 2022 06 8;18(2):170-175. Epub 2022 Mar 8.

University Center of Legal Medicine (CURML), Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Ogilvie's syndrome refers to a massive dilation of the colon without mechanical obstruction. Although this syndrome is well-known in the clinical literature and may sometimes be encountered as a complication of abdominal, pelvic, or hip surgery, it has only been reported sporadically in the forensic literature. We present the case of a forensic autopsy carried out on a patient whose death was related to cecal necrosis with acute peritonitis due to Ogilvie's syndrome following hip surgery. Read More

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Iatrogenic constipation in gastrointestinal surgery.

J Visc Surg 2022 03 13;159(1S):S51-S57. Epub 2022 Feb 13.

AP-HP, Hepato-Gastroenterology and Nutrition, Antoine-Béclère Hospital, Clamart, France; Paris-Saclay University, Inserm U996, Inflammation, Microbiome and Immunosurveillance, 92140 Clamart, France. Electronic address:

Postoperative constipation occurs relatively frequently, and can involve drug-related, surgical and lifestyle and dietary factors. Gastrointestinal motility can be altered by inflammation, surgery, opioid medications, hypnotics, anti-secretory or anesthetic drugs or by functional modifications for which the physiopathology is not well defined. There are a number of laxatives available. Read More

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Therapeutic utility of percutaneous cecostomy in adults: an updated systematic review.

Ther Adv Gastrointest Endosc 2022 Jan-Dec;15:26317745211073411. Epub 2022 Feb 4.

Department of Medicine, Faculty of Medicine, Umm Al-Qura University, Makkah, Al-Awali District, 24381 - 8156, Saudi Arabia.

Objective: Percutaneous cecostomy is a minimally invasive procedure that provides access to the colon for therapeutic interventions. This review aimed to update and summarize the existing information on the use and application of percutaneous endoscopic cecostomy in the field of therapeutic gastroenterology.

Data Sources: A systematic review of the literature was performed without any restrictions on the year of publication from the date of inception in 1986 to January 2021. Read More

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February 2022

Main Bronchus Stenosis Due to Tuberculosis and Ogilvie's Syndrome: A Case Report of Two Unusual Diseases in the Same Patient.

Cureus 2021 Dec 14;13(12):e20420. Epub 2021 Dec 14.

Thorax Surgery, Hospital Regional de Alta Especialidad del Bajío, León, MEX.

Main bronchus stenosis as a sequel of pulmonary tuberculosis is infrequent and should raise suspicion of other presentations of the infection. Given its non-specific symptomatology and the absence of a specific diagnostic method, tracheobronchial tuberculosis is usually not suspected and diagnosed despite its great impact on quality of life due to the high incidence of stenosis as a consequence. Ogilvie's syndrome, an uncommon condition, requires careful management and surveillance given the risk of ischemia and colonic perforation intrinsic to the disease. Read More

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December 2021

Ogilvie's syndrome-is there a cutoff diameter to proceed with upfront surgery?

Langenbecks Arch Surg 2022 May 12;407(3):1173-1182. Epub 2022 Jan 12.

Department of General and Visceral Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.

Purpose: Although Ogilvie's syndrome was first described about 70 years ago, its etiology and pathogenesis are still not fully understood. But more importantly, it is also not clear when to approach which therapeutic strategy.

Methods: Patients who were diagnosed with Ogilvie's syndrome at our institution in a 17-year time period (2002-2019) were included and retrospectively evaluated regarding different therapeutical strategies: conservative, endoscopic, or surgical. Read More

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Acute Colonic Pseudo-Obstruction in Severe Falciparum Malaria: A Case Report.

J Med Cases 2021 Dec 2;12(12):481-484. Epub 2021 Dec 2.

The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou 730050, China.

Severe falciparum malaria is associated with multiple organ dysfunctions. The most manifestations of severe falciparum malaria are cerebral malaria, acute lung injury, and acute kidney injury. Acute colonic pseudo-obstruction is extremely rare. Read More

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December 2021

The impact of acetylcholinesterase inhibitors on ileus and gut motility following abdominal surgery: a clinical review.

ANZ J Surg 2022 01 19;92(1-2):69-76. Epub 2021 Dec 19.

Colorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Postoperative ileus is a common complication in the days following colorectal surgery occurring in up to 50% of patients. When prolonged, this complication results in significant morbidity and mortality, doubling the total costs of hospital stay. Postoperative ileus (POI) results from the prolonged inflammatory phase that is mediated in part by the cholinergic anti-inflammatory pathway. Read More

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January 2022

[Etiological analysis and surgical method selection of adult megacolon].

J K Sui W Zhang

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Dec;24(12):1054-1057

Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Adult megacolon is a rare disease with heterogeneneous etiology. The treatment schemes of megacolon caused by different causes are also different, but surgery is the final and the most effective method. Due to the lack of early understanding of the disease, many patients have not been clearly diagnosed as adult megacolon and have not been properly treated. Read More

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December 2021

Acute Colonic Pseudo-Obstruction Following the Use of Dexmedetomidine.

Cureus 2021 Nov 11;13(11):e19465. Epub 2021 Nov 11.

Pulmonology and Critical Care, Veterans Affairs New York Harbor Health Care (VA NYHHS), Brooklyn, USA.

Dexmedetomidine is a preferred agent for light sedation with minimal adverse effects. We report a case of acute colonic pseudo-obstruction following dexmedetomidine use in a patient with alcohol withdrawal. He was treated with benzodiazepines first to control the withdrawal symptoms, then escalated to dexmedetomidine once delirium tremens ensued. Read More

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November 2021

Colonic Volvulus in Children: Surgical Management of a Challenging Condition.

Children (Basel) 2021 Oct 30;8(11). Epub 2021 Oct 30.

Pediatric Surgery Department, "Vittore Buzzi" Children's Hospital, 20154 Milano, Italy.

Colonic volvulus (CV) is a rare but potentially life-threatening condition with unclear etiopathogenesis. To date, less than 80 pediatric cases have been described. Hirschsprung's disease (HD) is associated with CV in 17% of cases, representing a significant risk factor. Read More

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October 2021

Hand-Assisted Laparoscopic Subtotal Colectomy for Ogilvie Syndrome Associated With Idiopathic Fibrosis of Colon After Simultaneous Pancreas Kidney Transplant.

Exp Clin Transplant 2021 12 10;19(12):1348-1351. Epub 2021 Nov 10.

From the Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Ogilvie syndrome (acute colonic pseudo-obstruction) is a rare, acquired, life-threatening disorder for which treatment plans vary from simple observation to surgical intervention. Ogilvie syndrome has been reported in patients after renal or liver transplant, but its occurrence after simultaneous pancreas-kidney transplant is rare. Herein, we present the case of a 45-year-old female recipient of a deceased donor simultaneous pancreas-kidney transplant who developed Ogilvie syndrome 10 days after a previous fecal ileus that had resolved at posttransplant week 3. Read More

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December 2021

Lower Gastrointestinal Functional and Motility Disorders in Children.

Pediatr Clin North Am 2021 12;68(6):1255-1271

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Gastroenterology and Hepatology, Neurogastroenterology and Motility Center, Yale School of Medicine, Yale University School of Medicine, Yale New Haven Children's Hospital, 333 Cedar Street, LMP 4093, PO Box 208064, New Haven, CT 06520, USA. Electronic address:

Functional and motility gastrointestinal disorders are the most common complaints to the pediatric gastroenterologist. Disorders affecting the small intestine carry a significant morbidity and mortality due to the severe limitation of therapeutic interventions available and the complications associated with such interventions. Congenital colorectal disorders are rare but also carry significant morbidity and poor quality of life plus the social stigma associated with its complications. Read More

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December 2021

An oral SARS-CoV-2 M inhibitor clinical candidate for the treatment of COVID-19.

Science 2021 Dec 2;374(6575):1586-1593. Epub 2021 Nov 2.

Pfizer Worldwide Research, Development & Medical, Cambridge, MA 02139, USA.

The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongoing threat presented by COVID-19. Here, we report the discovery and characterization of PF-07321332, an orally bioavailable SARS-CoV-2 main protease inhibitor with in vitro pan-human coronavirus antiviral activity and excellent off-target selectivity and in vivo safety profiles. Read More

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December 2021

A case of acute-colonic pseudo-obstruction (Ogilvie Syndrome) post robot-assisted radical prostatectomy.

Urol Case Rep 2022 Jan 5;40:101878. Epub 2021 Oct 5.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Acute Colonic Pseudo-obstruction (ACPO), or Ogilvie Syndrome, is a rare phenomenon where acute colonic distension occurs, in the absence of mechanical obstruction. Several post-operative cases of Ogilvie Syndrome are noted within the literature, pertaining to patients post hepatectomy, trauma or spinal surgery; but rarely following urological procedures. This case describes a 68-year-old gentleman who developed Ogilvie Syndrome post an uncomplicated robot-assisted radical prostatectomy (RARP). Read More

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January 2022

COVID-19 Case Fatality and Alzheimer's Disease.

J Alzheimers Dis 2021 ;84(4):1447-1452

Department of Neurology, University of Iowa, Iowa City, IA, USA.

Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. Read More

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December 2021

The Efficacy and Safety of Methylnaltrexone for the Treatment of Postoperative Ileus.

Am Surg 2022 Mar 13;88(3):409-413. Epub 2021 Oct 13.

12328Vanderbilt University Medical Center, Department of Surgery, Division of Trauma and Critical Care, Nashville, TN, USA.

Background: Postoperative ileus (POI) is a surgical complication resulting in increased morbidity and length of stay (LOS). Usual care for POI includes bowel rest and gastric decompression. It has been questioned if methylnaltrexone (MNTX), a peripheral opioid antagonist, could be used as treatment for POI. Read More

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Delayed avoidant restrictive food intake disorder diagnosis leading to Ogilvie's syndrome in an adolescent.

Eat Weight Disord 2022 Jun 8;27(5):1913-1918. Epub 2021 Oct 8.

Autism Reference Center, Department of Psychiatry, Rouen University Hospital, Rouen, France.

Purpose: Avoidant restrictive food intake disorder (ARFID) was recently characterized, according to the DSM-5 classification, as a feeding and eating disorder (FED). However, ARFID remains poorly known by most pediatricians, but also by psychiatrists and primary care professionals. Despite the fact that patients with ARFID generally have a higher BMI than patients with anorexia nervosa, our purpose was to highlight the fact that they may present severe nutritional deficiencies and major somatic complications when the diagnosis is delayed. Read More

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Interstitial cells of Cajal and human colon motility in health and disease.

Am J Physiol Gastrointest Liver Physiol 2021 11 6;321(5):G552-G575. Epub 2021 Oct 6.

Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

Our understanding of human colonic motility, and autonomic reflexes that generate motor patterns, has increased markedly through high-resolution manometry. Details of the motor patterns are emerging related to frequency and propagation characteristics that allow linkage to interstitial cells of Cajal (ICC) networks. In studies on colonic motor dysfunction requiring surgery, ICC are almost always abnormal or significantly reduced. Read More

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November 2021