Biomaterials 2019 09 28;214:119227. Epub 2019 May 28.
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Basic Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:
Though the cross-induction of either acute kidney (AKI) injury to ischemic stroke (IS) or IS to AKI might not be encountered in the early stages of cerebrorenal syndrome (CRS), both pathologies coexist in late stages. Therefore, we firstly established a late stage CRS rat model by simultaneous induction of both diseases, and further, cerebro and reno-protective activities of human platelet-rich plasma (hPRP), a blood-derived tissue engineering biomaterial, were tested in this pathology. hPRP was administrated via left common carotid artery and abdominal aorta 2 h post-sham procedure in Sprague-Dawley rats. Read More