172 results match your criteria Ocular Manifestations of Syphilis

Ocular Syphilis.

Surv Ophthalmol 2021 Jun 17. Epub 2021 Jun 17.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

Multiple studies around the world suggest that syphilis is re-emerging. Ocular syphilis - with a wide range of presentations, most of which are subtypes of uveitis - has become an increasingly common cause of ocular inflammation over the past 20 years. Its rising incidence, diagnostic complexity, and manifestations that have only recently been characterized make ocular syphilis relevant from the public health, clinical, and scientific perspectives. Read More

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Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis.

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

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The Clinical Spectrum and Outcome of Uveomeningitis: A Comprehensive Analysis of 110 Cases.

Ocul Immunol Inflamm 2021 May 11:1-6. Epub 2021 May 11.

Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, APHP-Centre Université de Paris (CUP), Paris, France.

Uveitis can be associated with meningitis (uveomeningitis) and the inflammation shared with the central nervous system. We aimed to describe the characteristics and outcome of uveomeningitis. We retrospectively analyzed 110 consecutive adult patients with uveomeningitis. Read More

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Ocular syphilis - a case series of four patients.

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

University Hospital and Clinic for Dermatology and Venereology, University Hospital Halle (Saale) of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Read More

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Diffuse Bilateral Subacute Placoid Chorioretinitis and Hot Optic Disc as Part of Ocular Manifestations of Neurosyphilis: A Case Report.

Klin Monbl Augenheilkd 2021 04 30;238(4):434-436. Epub 2021 Apr 30.

Department of Ophthalmology (Chairman Prof. Dr. med. Ch. Valmaggia), Kantonsspital St Gallen, Sankt Gallen, Switzerland.

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Ocular syphilis.

Clin Exp Optom 2021 Apr 8:1-4. Epub 2021 Apr 8.

Department of Optometry, Northwest Permanente-Kaiser Permanente, Portland, OR, USA.

Syphilis is a sexually transmitted, systemic, inflammatory disease caused by the spirochaete, . The natural history of untreated syphilis progresses through four distinct stages: primary, secondary, latent, and tertiary syphilis. Ocular involvement can occur at any stage of syphilis and any part of the eye can be affected. Read More

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Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis.

Trop Doct 2021 Mar 28:49475521998178. Epub 2021 Mar 28.

Department of Ophthalmology, 214250Army College of Medical Sciences & Base Hospital, Delhi, India.

Syphilis has a wide variety of ocular presentations such as anterior or posterior uveitis, chorioretinitis, retinal vasculitis, retinitis, perineuritis, papillitis, retrobulbar neuritis, optic atrophy and optic nerve gumma. Therefore, it is recommended to test every patient with ocular inflammation for syphilis. It is, however, a relatively rare cause of uveitis in HIV disease. Read More

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Ocular Findings in Infants with Congenital Toxoplasmosis after a Toxoplasmosis Outbreak.

Ophthalmology 2021 Mar 10. Epub 2021 Mar 10.

Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, SP, Brazil; Vision Institute, São Paulo, SP, Brazil.

Purpose: We investigated the prevalence of ocular abnormalities in infants vertically exposed to Toxoplasma gondii infection during an outbreak in Santa Maria City, Brazil.

Design: Consecutive case series.

Participants: A total of 187 infants were included. Read More

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Nodular syphilitic scleritis: a rare and forgotten entity.

Int J STD AIDS 2021 Jul 18;32(8):766-767. Epub 2021 Feb 18.

Department of Dermatology, Venerology, Leprosy, 29099Bangalore Medical College and Research Institute, India.

Ocular manifestations of syphilis are usually seen in the secondary or tertiary stages of the disease, which is a nonspecific inflammatory response. We report a case of unilateral nodular scleritis in a patient with late latent syphilis, which resolved with intravenous crystalline penicillin for 2 weeks, topical fluorometholone, and tobramycin eye drops for 3 weeks. Read More

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[Ocular manifestations of congenital syphilis. A case report].

A Hamma A Idder

J Fr Ophtalmol 2021 Mar 29;44(3):e149-e151. Epub 2020 Dec 29.

Université d'Oran, Oran, Algérie.

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Ocular Syphilis Presenting as Acute Necrotizing Retinitis in a Human Immunodeficiency Virus-Positive Patient.

J Glob Infect Dis 2020 Jul-Sep;12(3):149-151. Epub 2020 Aug 29.

Department of Ophthalmology, AIIMS, Bhubaneswar, Odisha, India.

The incidence of ocular syphilis is increasing in the developing world even in the era of effective human immunodeficiency virus (HIV) treatment, as there is a potential increase of high-risk sexual behavior. Ocular involvement in the form of uveitis is seen in all stages of syphilis. Diagnosis begins with ophthalmologic examination, but requires serologic testing for confirmation. Read More

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Utility of Treponemal Testing from Aqueous Fluid in the Diagnosis of Ocular Syphilis in Patients with HIV/AIDS.

Ocul Immunol Inflamm 2020 Oct 5:1-7. Epub 2020 Oct 5.

L & T Microbiology Research Centre, Sankara Nethralaya, Chennai, India.

: Ocular syphilis is re-emerging globally especially in patients with human immunodeficiency virus (HIV). Atypical manifestations of ocular syphilis and/or other associated opportunistic infections often lead to a diagnostic dilemma. We evaluated the utility of aqueous humor (AH) hemagglutination assay (TPHA) titers in the diagnosis of ocular syphilis. Read More

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October 2020

Acute syphilitic posterior placoid chorioretinopathy presenting as atypical multiple evanescent white dot syndrome.

Eur J Ophthalmol 2021 Mar 2;31(2):NP141-NP144. Epub 2020 Sep 2.

Fondation Ophtalmologique Adolphe de Rothschild, Service du Professeur Sahel, Paris, France.

Background: This paper reports the case of a young man who presented with syphilis masquerading as multiple evanescent white dots syndrome (MEWDS), which turned out to be an acute syphilitic posterior placoid chorioretinopathy (ASPPC) during follow-up.

Case Presentation: A 59-year-old healthy male consulted for a three days' history of visual impairment in both eyes. On multimodal imaging, he was diagnosed as MEWDS. Read More

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Ocular syphilis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy.

Indian J Ophthalmol 2020 Sep;68(9):1887-1893

Department of Uveitis, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: Re-emergent ocular syphilis in patients with Human immunodeficiency virus (HIV) co-infection has both diagnostic and management difficulties because of the overlapping risk factors. The clinical manifestations described in non-HIV may not be the same in patients with HIV coinfection. Immune recovery uveitis (IRU) may also alter the course of the disease causing recurrences. Read More

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September 2020

Clinical manifestations and outcomes of ocular syphilis in Asian Indian population: Analysis of cases presenting to a tertiary referral center.

Indian J Ophthalmol 2020 Sep;68(9):1881-1886

Smt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.

Purpose: To describe disease manifestations and outcomes of ocular syphilis in Asian Indian population.

Methods: Retrospective analysis of patients diagnosed with ocular syphilis at a tertiary referral center in India. Demographics, history, extraocular and ocular manifestations, ocular and systemic investigations, treatment and visual acuity outcomes were noted. Read More

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September 2020

Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.

Indian J Ophthalmol 2020 Sep;68(9):1787-1798

Department of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School; Schepens Eye Research Institute, Boston, Massachusetts, USA; MCM Eye Unit, MyungSung Christian Medical Center (MCM) General Hospital and MyungSung Medical College, Addis Ababa, Ethiopia.

Intraocular inflammation in patients with human immunodeficiency virus (HIV) infection is commonly due to infectious uveitis. Ocular lesions due to opportunistic infections (OI) are the most common and have been described extensively in the pre highly active antiretroviral therapy (HAART) era. Many eye lesions were classified as acquired immunodeficiency syndrome (AIDS) defining illnesses. Read More

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September 2020

Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals.

Ocul Immunol Inflamm 2020 Oct 13;28(7):1040-1048. Epub 2020 Jul 13.

Department of Ophthalmology and Otolaryngology, Faculdade de Medicina da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.

Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphilis in HIV-infected and -uninfected patients remains with some controversy due to unspecific clinical manifestations and limited diagnostic tests. Read More

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October 2020

Peripheral blood mononuclear cell microRNA profiles in syphilitic patients with serofast status.

Mol Biol Rep 2020 May 24;47(5):3407-3421. Epub 2020 Apr 24.

Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Syphilis is a chronic sexually transmitted disease caused by infection with Treponema pallidum, which can invade various system organs, leading to clinical manifestations such as neurosyphilis, ocular syphilis, and cardiovascular syphilis and seriously endangering human health. Serofast status is a common outcome after syphilis treatment that presents an important clinical problem. At present, the etiology of serofast status remains unknown. Read More

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Evaluation of the level of awareness of congenital toxoplasmosis and associated practices among pregnant women and health workers in Tanzania's Temeke district in Dar es Salaam.

Afr Health Sci 2019 Dec;19(4):3027-3037

University of Zambia School of Veterinary Medicine, clinical studies.

Background: Toxoplasmosis caused by the obligate intracellular coccidian protozoan T () infects all warm-blooded animals including humans. This parasite may develop in both immune-compromised and immunocompetent hosts but usually the disease manifestations strongly differ according to immune status. Immunocompromised hosts develop more severe disease than immunocompetent hosts. Read More

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December 2019

Prevalence of Self-reported Neurologic and Ocular Symptoms in Early Syphilis Cases.

Clin Infect Dis 2021 03;72(6):961-967

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Neurosyphilis, a complication of syphilis, can occur at any stage of infection. Measuring the prevalence of neurosyphilis is challenging, and there are limited data on the prevalence of neurologic or ocular symptoms among patients with syphilis. We sought to describe the prevalence of neurologic and/or ocular symptoms among early syphilis (ES) cases and the clinical management of symptomatic cases enrolled in the STD Surveillance Network (SSuN) Neuro/Ocular Syphilis Surveillance project. Read More

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Ocular syphilis in an immunocompetent host.

IDCases 2020 26;19:e00684. Epub 2019 Dec 26.

University Of Illinois College of Medicine, Department of Medicine, Peoria, IL, USA.

Syphilis is an old disease that experienced a resurgence with the emergence of HIV/AIDS. Syphilis is a reportable infection that is monitored by the Centers for disease Control (CDC) in the U.S. Read More

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December 2019

Ocular Syphilis: Clinical Manifestations and Treatment Course.

WMJ 2019 Dec;118(4):191-195

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin,

Introduction: We report 3 ocular syphilis cases that highlight the increasing incidence, variable presentation, diagnostic challenges, and treatment considerations of this potentially visionthreatening disease.

Case Series: A 39-year-old woman with diabetes and intravenous (IV) drug use presented with 3 weeks of decreased vision, left-eye photopsia, and rash. A 52-year-old man who has sex with men (MSM), presented with a 1-month history of upper respiratory infection-like symptoms, right-eye scotoma, redness, headache, and muffled hearing. Read More

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December 2019

Multimodal imaging patterns of posterior syphilitic uveitis: a review of the literature, laboratory evaluation and treatment.

Int Ophthalmol 2020 May 11;40(5):1319-1329. Epub 2020 Jan 11.

Eye Institute, Cleveland Clinic Abu Dhabi, Al Maryah Island, PO Box 112412, Abu Dhabi, UAE.

Purpose: To review the multimodal imaging patterns of posterior syphilitic uveitis.

Methods: A systematic review.

Results: The percentage of syphilis has started to increase again: The World Health Organization has reported 12 million new cases of syphilis each year. Read More

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Resurgence of ocular syphilis in British Columbia between 2013-2016: a retrospective chart review.

Can J Ophthalmol 2020 04 27;55(2):179-184. Epub 2019 Dec 27.

British Columbia Centre for Disease Control, Vancouver, B.C.. Electronic address:

Objective: To characterize the trends and explore the demographics, ophthalmic manifestations, and outcomes of ocular syphilis cases in British Columbia.

Design: Retrospective chart review.

Participants: Ocular syphilis cases reported to the British Columbia Centre for Disease Control (BCCDC) between January 2013 and December 2016. Read More

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Ocular and neurosyphilis: epidemiology and approach to management.

Ameeta E Singh

Curr Opin Infect Dis 2020 02;33(1):66-72

Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Purpose Of Review: In the context of a resurgence of syphilis worldwide, it can be anticipated that a rise in cases of ocular, otic, and neurosyphilis will also be seen. This article reviews the current epidemiology, manifestations, and approach to management and treatment.

Recent Findings: Although studies continue investigating alternate approaches and new diagnostic tests for ocular and neurosyphilis, few data exist to change current diagnostic algorithms and approaches to diagnosis, management, or follow up. Read More

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February 2020

Angiography and En Face Optical Coherence Tomography Findings in Acute Syphilitic Posterior Placoid Chorioretinopathy.

Case Rep Ophthalmol 2019 May-Aug;10(2):165-171. Epub 2019 May 23.

Uveitis Unit, Hospital Clinic de Barcelona, Instituto de Oftalmología, Facultad de Medicina, Universidad de Barcelona, Barcelona, Spain.

Acute syphilitic posterior placoid chorioretinopathy (ASPPC) is one of the rarest ocular manifestations of syphilis. The pathophysiology of this entity is still unknown. We report the outer retinal findings on en face optical coherence tomography (OCT) and the alteration of choriocapillaris flow findings on OCT angiography in a patient with ASPPC at the time of presentation, after penicillin treatment completion and during follow-up. Read More

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Intermediate Uveitis as the Initial and Only Presentation of Syphilis

Turk J Ophthalmol 2019 Oct;49(5):297-299

University of Health Sciences, Beyoğlu Eye Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey

We report a patient with unilateral syphilitic intermediate uveitis without dermatological, neurological, or any systemic involvement. He presented to our clinic with complaints of eye floaters and worsening visual acuity in the left eye. He had intermediate uveitis and cystoid macular edema in that eye and both venereal disease research laboratory and microhemagglutination assay for serological tests were confirmatory for syphilis. Read More

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October 2019

Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis.

Ocul Immunol Inflamm 2021 Jan 24;29(1):95-101. Epub 2019 Oct 24.

Ophthalmology, CHU Saint-Pierre and Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

: To evaluate neurosyphilis cerebrospinal fluid (CSF) findings and initial ophthalmic manifestations in patients with syphilitic uveitis.: We retrospectively reviewed the records of CSF analysis of 14 patients with syphilitic uveitis with treponemal analysis - chemiluminescent immunoassay and TPHA- and non-treponemal analysis - Rapid Plasma Reagin test - RPR.: 86% were males and 43% HIV+. Read More

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January 2021

Intravitreal sustained-release dexamethasone implant for the treatment of persistent cystoid macular edema in ocular syphilis.

Indian J Ophthalmol 2019 09;67(9):1487-1490

Department of Uvea, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India.

With a resurgence of syphilis with human immunodeficiency virus (HIV) infection in last few years, various ocular manifestations of syphilis have been described in literature. This case report described an HIV-positive patient on anti-retroviral therapy who was diagnosed and treated for posterior uveitis secondary to ocular syphilis in the recent past presented to our clinic with cystoid macular edema (CME). CME, which did not respond to periocular corticosteroid, resolved with intravitreal sustained release dexamethasone implant. Read More

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September 2019