137 results match your criteria Ocular Manifestations of Syphilis


[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0854-3421
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http://dx.doi.org/10.1055/a-0854-3421DOI Listing
April 2019
1 Read

[The ocular manifestations of human immunodeficiency virus and syphilis coinfection].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.008DOI Listing
April 2019
2 Reads

Presentation of Ocular Syphilis in a HIV-Positive Patient with False-Negative Serologic Screening.

Case Rep Infect Dis 2019 3;2019:8191724. Epub 2019 Feb 3.

Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ, USA.

Purpose: The ocular sequelae of syphilis are devastating and may cause blindness. The ambiguous nature of its ocular manifestations makes syphilis difficult to detect. Though uncommon, the rise of syphilis in the United States requires a renewed understanding of its ophthalmic presentation to prevent devastating outcomes. Read More

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http://dx.doi.org/10.1155/2019/8191724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377954PMC
February 2019
1 Read

Multimodal Imaging of Atypical Acute Syphilitic Posterior Placoid Chorioretinitis Mimicking a White Dot Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2019 02;50(2):e52-e55

As rates of infectious syphilis continue to rise in the U.S., it is important to be familiar with known manifestations of ocular syphilis as well as report presentations not previously described in the literature. Read More

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http://dx.doi.org/10.3928/23258160-20190129-20DOI Listing
February 2019

Author Correction: Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.

Sci Rep 2018 Oct 23;8(1):15902. Epub 2018 Oct 23.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More

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http://www.nature.com/articles/s41598-018-34170-8
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http://dx.doi.org/10.1038/s41598-018-34170-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198005PMC
October 2018
19 Reads

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis.

Acta Ophthalmol 2018 Oct 17. Epub 2018 Oct 17.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Ocular manifestations of syphilis have been reported in 2-10% of systemic infection. The purpose of this study was to report the incidence of ocular syphilis and various ocular manifestations, particularly optic nerve involvement, in newly diagnosed cases.

Methods: This was a retrospective study. Read More

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http://dx.doi.org/10.1111/aos.13963DOI Listing
October 2018
4 Reads

Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis.

Ocul Immunol Inflamm 2018 Sep 19:1-5. Epub 2018 Sep 19.

a Department of Ophthalmology , Groote Schuur Hospital , Cape Town , South Africa.

Purpose: To review the clinical manifestations, cerebrospinal fluid findings and outcomes of patients diagnosed with ocular syphilis.

Methods: Retrospective case review of all patients treated with ocular syphilis at Groote Schuur Hospital in Cape Town, South Africa between January 2008 and January 2013.

Results: A total of 77 eyes of 49 patients were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1521436DOI Listing
September 2018
24 Reads

Ocular Manifestations of Human Immunodeficiency Virus Infection at a Tertiary Referral Center in Taiwan.

Ocul Immunol Inflamm 2018 Sep 6:1-6. Epub 2018 Sep 6.

a Department of Ophthalmology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.

Purpose: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) Materials and Methods: A retrospective cohort study in Taiwan was performed between January 2006 and July 2016. Ocular examination and systemic information were recorded from the HIV-infected patients.

Results: 1242 patients with HIV/AIDS were identified. Read More

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http://dx.doi.org/10.1080/09273948.2018.1499939DOI Listing
September 2018
6 Reads

Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.

Sci Rep 2018 Aug 13;8(1):12071. Epub 2018 Aug 13.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

Recent reports from different world regions suggest ocular syphilis is re-emerging, in parallel with an increasing incidence of the systemic infection globally. We conducted a large observational study of 127 persons consecutively treated for ocular syphilis at public medical centers in Brazil over a 2.5-year period ending July 2015. Read More

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http://dx.doi.org/10.1038/s41598-018-30559-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089995PMC
August 2018
11 Reads

Specialty management differences of syphilis and toxoplasmosis surrounding pregnancy: a prospective cross-sectional study.

J Ophthalmic Inflamm Infect 2018 Jul 3;8(1):10. Epub 2018 Jul 3.

Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Court, Mail Stop F731, Aurora, CO, 80045, USA.

Background: Syphilis and toxoplasmosis are two infectious conditions that can occur during pregnancy. Both these diseases can have ocular manifestations and thus are treated by ophthalmologists and obstetricians. We hypothesized that specialty training would affect the way physicians selected therapy. Read More

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http://dx.doi.org/10.1186/s12348-018-0152-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029981PMC
July 2018
24 Reads

Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient.

Case Rep Infect Dis 2018 18;2018:2840241. Epub 2018 Feb 18.

University of Nebraska Medical Center, S. 42nd and Emile St., Omaha, NE, USA.

. is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Read More

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http://dx.doi.org/10.1155/2018/2840241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835303PMC
February 2018
7 Reads

Secondary pulmonary syphilis: Case report and review of literature.

Ann Dermatol Venereol 2018 Apr 17;145(4):278-287. Epub 2018 Feb 17.

Service de dermatologie, hôpital Emile-Muller, GHR Mulhouse-Sud Alsace, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.

Introduction: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review.

Patients And Methods: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. Read More

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http://dx.doi.org/10.1016/j.annder.2017.11.015DOI Listing
April 2018
4 Reads

Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.

Medicine (Baltimore) 2017 Oct;96(43):e8376

aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

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http://dx.doi.org/10.1097/MD.0000000000008376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671864PMC
October 2017
31 Reads

Increases in Ocular Syphilis-North Carolina, 2014-2015.

Clin Infect Dis 2017 Oct;65(10):1676-1682

North Carolina Division of Public Health, Raleigh.

Background: Ocular syphilis is an inflammatory eye disease due to Treponema pallidum infection. In the United States, syphilis rates have increased since 2000; clusters of ocular syphilis were reported in 2015. We investigated ocular syphilis in North Carolina to describe the epidemiology and clinical course of disease. Read More

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http://dx.doi.org/10.1093/cid/cix604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740484PMC
October 2017
18 Reads

Ocular syphilis masquerading as bilateral peripheral ulcerative keratitis.

Taiwan J Ophthalmol 2016 Oct-Dec;6(4):204-205. Epub 2016 Jul 16.

Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India.

Ocular syphilis has varied manifestations in the eye. Peripheral ulcerative keratitis (PUK) is a crescent-shaped ulcer involving the peripheral cornea and associated with thinning. PUK is caused by both autoimmune and infectious diseases, such as rheumatoid arthritis, tuberculosis, and herpes. Read More

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http://dx.doi.org/10.1016/j.tjo.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525632PMC
July 2016
17 Reads

[Neurosyphilis: A retrospective study of 13 cases at Strasbourg University Hospital].

J Fr Ophtalmol 2017 Oct 1;40(8):654-660. Epub 2017 Sep 1.

Laboratoire de bactériologie, CHU de Strasbourg, 67000 Strasbourg, France.

Objective: After a decade of constant decline, the number of syphilis cases has been steadily increasing since the 2000s, particularly in HIV infected patients. Neurosyphilis is a rare manifestation of this sexually transmitted disease for which we performed a retrospective study and analyzed clinical manifestations.

Patients And Methods: We reviewed retrospectively all the neurosyphilis cases admitted to Strasbourg University Hospital between 2004 and 2014. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.03.007DOI Listing
October 2017
9 Reads

Neurosyphilis in Africa: A systematic review.

PLoS Negl Trop Dis 2017 Aug 31;11(8):e0005880. Epub 2017 Aug 31.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Introduction: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597251PMC
August 2017
34 Reads

UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS.

Retin Cases Brief Rep 2017 Aug 14. Epub 2017 Aug 14.

*Department of Neurology, Indiana University, Indianapolis, Indiana; †Indiana University School of Medicine, Indianapolis, Indiana; and Departments of ‡Neurosurgery, and §Ophthalmology, Indiana University, Indianapolis, Indiana.

Purpose: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis.

Methods: A case report of a 22-year-old man with progressive unilateral vision loss.

Results: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. Read More

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http://Insights.ovid.com/crossref?an=01271216-900000000-9895
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http://dx.doi.org/10.1097/ICB.0000000000000614DOI Listing
August 2017
15 Reads

Infectious uveitis: An enigma.

Middle East Afr J Ophthalmol 2017 Jan-Mar;24(1):2-10

Department of Uvea, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Infectious uveitis accounts for majority of the cases of uveitis in developing countries. It also encompasses an array of various microorganisms and their clinical presentations. Some of these infectious uveitic entities are familiar, while others are newly emerging in the global ophthalmic world. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_252_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433124PMC
June 2017
44 Reads

Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela.

JAMA Ophthalmol 2017 05;135(5):440-445

Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland8Johns Hopkins Zika Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. Read More

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2017.0561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470423PMC
May 2017
12 Reads

Uveitis as an initial manifestation of acquired immunodeficiency syndrome.

Int J STD AIDS 2017 10 15;28(12):1224-1228. Epub 2017 Feb 15.

1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a multisystem disease that can involve the human eyes. Using ophthalmic examination records from January 2006 to November 2015, we retrospectively reviewed all patients who were diagnosed with HIV/AIDS in our hospital. The study was performed at a tertiary referral center in southern Taiwan. Read More

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http://dx.doi.org/10.1177/0956462417694569DOI Listing
October 2017
19 Reads

[Clinical features of neurosyphilis with optic neuritis as an initial finding].

Zhonghua Yan Ke Za Zhi 2016 Dec;52(12):898-904

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.

To study the characteristics of neurosyphilis with optic neuritis as an initial finding. Retrospective analysis of clinical data and laboratory testing results of 16 cases (27 eyes) with optic neuritis as an initial finding of neurosyphilis from October 2010 to March 2015 in General Hospital of People's Liberation Army was made. Six-teen patients (12 males, 4 females) were collected, the median age of patients was 47 (range 33 to 65) years ,the mean age was (49. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2016.12.006DOI Listing
December 2016
6 Reads

Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015.

MMWR Morb Mortal Wkly Rep 2016 Nov 4;65(43):1185-1188. Epub 2016 Nov 4.

Ocular syphilis, a manifestation of Treponema pallidum infection, can cause a variety of ocular signs and symptoms, including eye redness, blurry vision, and vision loss. Although syphilis is nationally notifiable, ocular manifestations are not reportable to CDC. Syphilis rates have increased in the United States since 2000. Read More

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http://dx.doi.org/10.15585/mmwr.mm6543a2DOI Listing
November 2016
16 Reads

Changes in neurosyphilis presentation: a survey on 286 patients.

J Eur Acad Dermatol Venereol 2016 Nov 15;30(11):1886-1900. Epub 2016 Jun 15.

Di.S.Sal. Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.

Although neurosyphilis (NS) keeps plaguing worldwide, often with oligosymptomatic and atypical manifestations, the most recent reports fail to provide useful information, like details of the clinical history and even of the previous early therapy. We conducted a survey of the literature of the last 5 years on the clinical presentation of NS, recording the aforementioned inaccuracies. One hundred and thirty-seven articles were collected, reporting on 286 patients. Read More

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http://dx.doi.org/10.1111/jdv.13753DOI Listing
November 2016
11 Reads

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes.

Korean J Ophthalmol 2016 Oct 29;30(5):360-368. Epub 2016 Sep 29.

Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.

Purpose: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection.

Methods: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Read More

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http://dx.doi.org/10.3341/kjo.2016.30.5.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057012PMC
October 2016
9 Reads

Necrotizing retinitis due to syphilis in a patient with AIDS.

IDCases 2016 21;6:17-9. Epub 2016 Aug 21.

Indiana University Department of Medicine, United States.

The ocular manifestations of syphilis are varied. Ocular syphilis can occur during any stage of infection and involve virtually any part of the eye. In immunocompetent individuals, the most common etiologies include syphilitic uveitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021766PMC
September 2016
10 Reads

Acute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis.

Authors:
Sanjeet K Shahi

Clin Exp Optom 2017 May 31;100(3):208-213. Epub 2016 Aug 31.

Department of Veterans Affairs, Ocala, Florida, USA.

Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Read More

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http://dx.doi.org/10.1111/cxo.12449DOI Listing
May 2017
7 Reads

[Atypical acute syphilitic posterior placoid chorioretinitis].

Ophthalmologe 2017 Jun;114(6):563-566

Augenklinik, Semmelweis Universität, Mária Str. 39, 1085, Budapest, Ungarn.

Syphilis is an infectious disease that can cause a wide variety of ocular signs. One of the rarest manifestations of ocular syphilis is acute syphilitic posterior placoid chorioretinitis (ASPPC). We report the case of an immunocompetent 38-year-old woman diagnosed with unilateral, atypical, acute syphilitic posterior placoid chorioretinitis. Read More

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http://dx.doi.org/10.1007/s00347-016-0327-4DOI Listing
June 2017
6 Reads

Don't Forget What You Can't See: A Case of Ocular Syphilis.

West J Emerg Med 2016 Jul 21;17(4):473-6. Epub 2016 Jun 21.

University of Texas, Health Science Center, San Antonio, Department of Emergency Medicine, San Antonio, Texas.

This case describes an emergency department (ED) presentation of ocular syphilis in a human immunodeficiency virus (HIV) infected patient. This is an unusual presentation of syphilis and one that emergency physicians should be aware of. The prevalence of syphilis has reached epidemic proportions since 2001 with occurrences primarily among men who have sex with men (MSM). Read More

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http://dx.doi.org/10.5811/westjem.2016.5.28933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944808PMC
July 2016
15 Reads

Molecular Typing of Treponema pallidum in Ocular Syphilis.

Sex Transm Dis 2016 08;43(8):524-7

From the *Centers for Disease Control and Prevention, Atlanta, GA; †Department of Neurology, and ‡Department of Medicine (Infectious Diseases), University of Washington School of Medicine, Seattle, WA.

Background: Syphilis can have many clinical manifestations, including eye involvement, or "ocular syphilis." In 2015, an increase in reported cases of ocular syphilis and potential case clusters raised concern for an oculotropic strain of Treponema pallidum, the infectious agent of syphilis. Molecular typing was used to examine strains found in cases of ocular syphilis in the United States. Read More

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http://pdfs.journals.lww.com/stdjournal/2016/08000/Molecular
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http://dx.doi.org/10.1097/OLQ.0000000000000478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253705PMC
August 2016
23 Reads

Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients.

BMC Infect Dis 2016 06 6;16:245. Epub 2016 Jun 6.

Department of Dermatology, Shanghai Xuhui Central Hospital, Shanghai, People's Republic of China.

Background: Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients.

Methods: The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1186/s12879-016-1586-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895961PMC
June 2016
10 Reads

[Ocular Manifestations in Sarcoidosis].

Klin Monbl Augenheilkd 2016 May 17;233(5):594-600. Epub 2016 May 17.

Augenabteilung, St. Franziskus-Hospital Münster.

Sarcoidosis is an inflammatory multi-organ disease of unknown pathogenesis, characterised by non-necrotising granulomata. Sarcoidosis predominantly manifests in the lung, but any other organ may be affected. Ocular involvement is present in about 25 to 50 % of patients. Read More

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http://dx.doi.org/10.1055/s-0042-104063DOI Listing
May 2016
9 Reads

Syphilitic placoid chorioretinitis. A case-report.

Arch Soc Esp Oftalmol 2016 May 23;91(5):232-5. Epub 2016 Feb 23.

Servicio de Oftalmología, Hospital Universitario de León, León, España; Instituto de Biomedicina (IBIOMED), Universidad de León, León, España.

Clinical Case: We report the case of a 45-year-old woman, with unremarkable past medical history, who presented with acute visual loss in her left eye due to bilateral posterior uveitis. After the screening, she was diagnosed with acute syphilitic placoid chorioretinitis and was treated with intravenous penicillin.

Discussion: Clinical manifestations of ocular syphilis are extremely heterogeneous and may mimic several aetiologies. Read More

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http://dx.doi.org/10.1016/j.oftal.2016.01.005DOI Listing
May 2016
5 Reads

[Ocular manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus].

Zhonghua Yan Ke Za Zhi 2015 Oct;51(10):739-45

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China; Email:

Objective: To investigate the clinical manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus (HIV).

Methods: Uveoretinitis patients presenting between January 2008 and December 2014 at Eye and ENT Hospital of Fudan University were collected. Patients were selected with positive serologic tests, including rapid plasma regain titer (RPR) > 1:8, treponema pallidum particle agglutination assay (TPPA) and human immunodeficiency virus (HIV). Read More

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October 2015
13 Reads

[Ocular syphilis: A retrospective study of 27 cases in Nantes University Hospital (France) from 2000 to 2013].

Rev Med Interne 2015 Nov 19;36(11):722-7. Epub 2015 Sep 19.

Service d'ophtalmologie, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

Introduction: Syphilis may manifest as several distinct ophthalmological forms. The main objective of our study was to describe the diagnostic, therapeutic data and prognosis of ocular syphilis.

Patients And Methods: We retrospectively analysed the cases of syphilitic uveitis diagnosed in the University Hospital of Nantes between 2000 and 2013. Read More

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http://dx.doi.org/10.1016/j.revmed.2015.07.008DOI Listing
November 2015
6 Reads

Clinical and laboratory characteristics of ocular syphilis: a new face in the era of HIV co-infection.

J Ophthalmic Inflamm Infect 2015 Dec 22;5(1):56. Epub 2015 Aug 22.

Department of Ophthalmology, USC Eye Institute, Keck School of Medicine of the University of Southern California, 1450 San Pablo St., Suite 4000, Los Angeles, CA, 90033, USA,

Background: Ocular syphilis is reemerging as an important cause of uveitis in the new era of common co-infection with HIV. This study will reveal the clinical and laboratory characteristics in the group of individuals co-infected with ocular syphilis and HIV compared with HIV-negative individuals. In this retrospective observational case series, medical records of patients diagnosed with ocular syphilis with serologic support from 2008 to 2014 were reviewed. Read More

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http://dx.doi.org/10.1186/s12348-015-0056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546070PMC
December 2015
6 Reads

Ocular syphilis: an alarming infectious eye disease.

Int J Clin Exp Med 2015 15;8(5):7770-7. Epub 2015 May 15.

Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, P. R. China.

Background: To describe the clinical manifestations and ancillary examination outcomes of ocular syphilis in Southeast China.

Materials And Methods: This is a retrospective, nonrandom case study. Demographic information, serum and cerebrospinal fluid (CSF) test results, and findings of fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and spectral domain optical coherence tomography (SD-OCT) were analyzed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509273PMC
July 2015
60 Reads

Syphilitic uveitis and optic neuritis in Sydney, Australia.

Br J Ophthalmol 2015 Sep 18;99(9):1215-9. Epub 2015 Mar 18.

Save Sight Institute, Discipline of Ophthalmology, Sydney Eye Hospital Campus, The University of Sydney, Sydney, Australia.

Aims: To describe ocular syphilis presentations to a tertiary referral eye hospital over a 5-year period and to document HIV coinfection frequency.

Methods: A retrospective chart review was conducted of consecutive ocular syphilis presentations to Sydney Eye Hospital from 2007 to 2012. Inclusion criteria were positive syphilis serology, ocular inflammation on clinical examination and appropriate syphilis treatment. Read More

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http://bjo.bmj.com/content/99/9/1215.full.pdf
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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2014-3061
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http://dx.doi.org/10.1136/bjophthalmol-2014-306168DOI Listing
September 2015
7 Reads

[Clinical and paraclinical features of syphilitic uveitis].

J Fr Ophtalmol 2015 Mar 28;38(3):220-8. Epub 2015 Jan 28.

Service d'ophtalmologie, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003, Lyon, France.

Introduction: Syphilis, caused by Treponema pallidum agent, results in polymorphic and non-specific ocular manifestations. Early diagnosis and institution of individualized treatment play a large role in the prognosis. The increase in syphilis over the past several years requires the ophthalmologist to consider this diagnosis in the setting of any intraocular inflammatory involvement. Read More

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http://dx.doi.org/10.1016/j.jfo.2014.09.011DOI Listing
March 2015
21 Reads

Ocular syphilis.

Authors:
Janet L Davis

Curr Opin Ophthalmol 2014 Nov;25(6):513-8

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Purpose Of Review: Review current literature relevant to syphilitic uveitis utilizing Medline search and online governmental resources relevant to the diagnosis and management of syphilis presenting with ocular manifestations.

Recent Findings: There is a trend for increasing frequency of primary and secondary syphilis in developed countries, especially in young men. Ocular manifestations of syphilis are rare, occurring in less than one in 1 million persons in the United Kingdom. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000099DOI Listing
November 2014
13 Reads

Granulomatous disease in the head and neck: developing a differential diagnosis.

Radiographics 2014 Sep-Oct;34(5):1240-56

From the Departments of Radiology (O.K.N., R.N., A.F., O.S.) and Otolaryngology-Head and Neck Surgery (O.S.), Boston Medical Center, Boston University School of Medicine, 820 Harrison Ave, Boston, MA 02118.

Granulomatous diseases have a varied etiology that includes autoimmune, infectious, idiopathic, and hereditary causes. The unifying factor in these diseases is the formation of granulomas, which histologically are mononuclear inflammatory cells or macrophages surrounded by lymphocytes. Granulomatous diseases often have systemic manifestations that affect organs throughout the body. Read More

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http://dx.doi.org/10.1148/rg.345130068DOI Listing
November 2015
21 Reads

[Ocular syphilis].

J Fr Ophtalmol 2014 Apr 18;37(4):329-36. Epub 2014 Mar 18.

Clinique universitaire d'ophtalmologie, CHU de Grenoble, université J.-Fourier, BP 217, 38043 Grenoble cedex 09, France.

Syphilis is a sexually transmitted disease caused by Treponema pallidum. Previously known as the "great imitator", this disease can have numerous and complex manifestations. The ophthalmologist should suspect the diagnosis in patients with uveitis or optic neuropathy and high-risk sexual behavior and/or another sexually transmitted disease (such as HIV) or those presenting with posterior placoid chorioretinitis or necrotising retinitis. Read More

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http://dx.doi.org/10.1016/j.jfo.2013.12.006DOI Listing
April 2014
3 Reads

Neurological Findings in Early Syphilis: a Comparison Between HIV Positive and Negative Patients.

Neurol Int 2013 11;5(4):e19. Epub 2013 Nov 11.

Central Military Hospital , Mexico City, Mexico.

After a decade of steady decline, syphilis has reemerged within the past few years and it is seeping back into the HIV negative population. We describe herein 16 consecutive cases of neurosyphilis and compare its clinical characteristics. Of the 16 patients, 14 (87%) were men. Read More

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http://www.pagepress.org/journals/index.php/ni/article/view/
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http://dx.doi.org/10.4081/ni.2013.e19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883064PMC
January 2014
16 Reads

Syphilitic uveitis in a Singaporean population.

Ocul Immunol Inflamm 2014 Feb 24;22(1):9-14. Epub 2013 Sep 24.

Yong Loo Lin School of Medicine, National University of Singapore , Singapore .

Purpose: To report the presentations of syphilitic uveitides in Singapore.

Methods: Retrospective noncomparative observational case series of 18 eyes from 12 patients with ocular syphilis between 2004 and 2009.

Results: Patients were mainly male (91. Read More

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http://dx.doi.org/10.3109/09273948.2013.829106DOI Listing
February 2014
11 Reads
8 Citations
1.440 Impact Factor

Uveitis and desquamating rash of the palms and soles.

Am J Dermatopathol 2013 Jun;35(4):494-5

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9190, USA.

Syphilis, a sexually transmitted disease caused by the spirochete Treponema pallidum, can affect nearly every organ system in the body. In particular, skin manifestations of secondary syphilis are common but nonspecific and can be a true masquerader of other skin disorders. Concomitant infection with HIV has been increasing and may cause even more unusual skin presentations. Read More

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http://dx.doi.org/10.1097/DAD.0b013e31827654aeDOI Listing
June 2013
2 Reads

Myriad ocular manifestations of one of the oldest human scourges in the eye.

Graefes Arch Clin Exp Ophthalmol 2013 Sep 4;251(9):2291-3. Epub 2013 Apr 4.

Wake Forest University Eye Center, Wake Forest University, Winston Salem, NC, 27106, USA.

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http://dx.doi.org/10.1007/s00417-013-2320-9DOI Listing
September 2013
4 Reads

[Cogan syndrome].

Authors:
Thierry Zenone

Presse Med 2013 Jun 13;42(6 Pt 1):951-60. Epub 2013 Mar 13.

Centre hospitalier de Valence, département de médecine interne, France.

Cogan's syndrome is a rare disorder of unknown origin characterized by inflammatory ocular disease (mainly interstitial keratitis) and audiovestibular symptoms (mainly acute-onset sensorineural hearing loss) in the setting of a negative work-up for syphilis. The diversity of the ocular and audiovestibular manifestations reported in the literature in atypical Cogan's syndrome should make one cautious before accepting the diagnosis as the disease may mimic various other systemic disorders. Systemic corticosteroids are always the most widely used and successful therapy. Read More

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http://dx.doi.org/10.1016/j.lpm.2012.09.035DOI Listing
June 2013
3 Reads

Ocular syphilis, a case of acute posterior placoid chorioretinitis.

Authors:
M C Veys B Lafaut

Bull Soc Belge Ophtalmol 2013 (322):21-5

Purpose: To report a case of acute posterior placoid chorioretinitis, a rare manifestation of ocular syphilis.

Methods: The patient was examined at age 59 with symptoms of subacute severe unilateral vision loss of the right eye. He underwent fundus examination, automated perimetry, optical coherence tomography imaging and fluorescein angiography. Read More

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July 2014
13 Reads

Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature.

Retina 2012 Oct;32(9):1915-41

The LuEsther T. Mertz Retina Research Center of Manhattan Eye, Ear and Throat Hospital, New York, New York, USA.

Purpose: To describe the clinical and angiographic features of a series of patients with acute syphilitic posterior placoid chorioretinitis (ASPPC) in the context of previously published cases.

Methods: A retrospective, noncomparative, multicenter chart review was performed on 16 patients with active ASPPC. Positive serologic tests supported the diagnosis in all patients. Read More

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http://dx.doi.org/10.1097/IAE.0b013e31825f3851DOI Listing
October 2012
17 Reads
21 Citations
3.243 Impact Factor