Search our Database of Scientific Publications and Authors

I’m looking for a

    126 results match your criteria Ocular Manifestations of Syphilis

    1 OF 3

    Secondary pulmonary syphilis: Case report and review of literature.
    Ann Dermatol Venereol 2018 Feb 17. Epub 2018 Feb 17.
    Service de dermatologie, hôpital Emile-Muller, GHR Mulhouse-Sud Alsace, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.
    Introduction: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review.

    Patients And Methods: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. Read More

    Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.
    Medicine (Baltimore) 2017 Oct;96(43):e8376
    aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
    Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

    Increases in Ocular Syphilis-North Carolina, 2014-2015.
    Clin Infect Dis 2017 Oct;65(10):1676-1682
    North Carolina Division of Public Health, Raleigh.
    Background: Ocular syphilis is an inflammatory eye disease due to Treponema pallidum infection. In the United States, syphilis rates have increased since 2000; clusters of ocular syphilis were reported in 2015. We investigated ocular syphilis in North Carolina to describe the epidemiology and clinical course of disease. Read More

    Ocular syphilis masquerading as bilateral peripheral ulcerative keratitis.
    Taiwan J Ophthalmol 2016 Oct-Dec;6(4):204-205. Epub 2016 Jul 16.
    Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India.
    Ocular syphilis has varied manifestations in the eye. Peripheral ulcerative keratitis (PUK) is a crescent-shaped ulcer involving the peripheral cornea and associated with thinning. PUK is caused by both autoimmune and infectious diseases, such as rheumatoid arthritis, tuberculosis, and herpes. Read More

    [Neurosyphilis: A retrospective study of 13 cases at Strasbourg University Hospital].
    J Fr Ophtalmol 2017 Oct 1;40(8):654-660. Epub 2017 Sep 1.
    Laboratoire de bactériologie, CHU de Strasbourg, 67000 Strasbourg, France.
    Objective: After a decade of constant decline, the number of syphilis cases has been steadily increasing since the 2000s, particularly in HIV infected patients. Neurosyphilis is a rare manifestation of this sexually transmitted disease for which we performed a retrospective study and analyzed clinical manifestations.

    Patients And Methods: We reviewed retrospectively all the neurosyphilis cases admitted to Strasbourg University Hospital between 2004 and 2014. Read More

    Neurosyphilis in Africa: A systematic review.
    PLoS Negl Trop Dis 2017 Aug 31;11(8):e0005880. Epub 2017 Aug 31.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Introduction: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Read More

    Retin Cases Brief Rep 2017 Aug 14. Epub 2017 Aug 14.
    *Department of Neurology, Indiana University, Indianapolis, Indiana; †Indiana University School of Medicine, Indianapolis, Indiana; and Departments of ‡Neurosurgery, and §Ophthalmology, Indiana University, Indianapolis, Indiana.
    Purpose: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis.

    Methods: A case report of a 22-year-old man with progressive unilateral vision loss.

    Results: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. Read More

    Infectious uveitis: An enigma.
    Middle East Afr J Ophthalmol 2017 Jan-Mar;24(1):2-10
    Department of Uvea, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Infectious uveitis accounts for majority of the cases of uveitis in developing countries. It also encompasses an array of various microorganisms and their clinical presentations. Some of these infectious uveitic entities are familiar, while others are newly emerging in the global ophthalmic world. Read More

    Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela.
    JAMA Ophthalmol 2017 May;135(5):440-445
    Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland8Johns Hopkins Zika Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. Read More

    Uveitis as an initial manifestation of acquired immunodeficiency syndrome.
    Int J STD AIDS 2017 10 15;28(12):1224-1228. Epub 2017 Feb 15.
    1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a multisystem disease that can involve the human eyes. Using ophthalmic examination records from January 2006 to November 2015, we retrospectively reviewed all patients who were diagnosed with HIV/AIDS in our hospital. The study was performed at a tertiary referral center in southern Taiwan. Read More

    [Clinical features of neurosyphilis with optic neuritis as an initial finding].
    Zhonghua Yan Ke Za Zhi 2016 Dec;52(12):898-904
    Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
    To study the characteristics of neurosyphilis with optic neuritis as an initial finding.Retrospective analysis of clinical data and laboratory testing results of 16 cases (27 eyes) with optic neuritis as an initial finding of neurosyphilis from October 2010 to March 2015 in General Hospital of People's Liberation Army was made.Six-teen patients (12 males, 4 females) were collected, the median age of patients was 47 (range 33 to 65) years ,the mean age was (49. Read More

    Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015.
    MMWR Morb Mortal Wkly Rep 2016 Nov 4;65(43):1185-1188. Epub 2016 Nov 4.
    Ocular syphilis, a manifestation of Treponema pallidum infection, can cause a variety of ocular signs and symptoms, including eye redness, blurry vision, and vision loss. Although syphilis is nationally notifiable, ocular manifestations are not reportable to CDC. Syphilis rates have increased in the United States since 2000. Read More

    Changes in neurosyphilis presentation: a survey on 286 patients.
    J Eur Acad Dermatol Venereol 2016 Nov 15;30(11):1886-1900. Epub 2016 Jun 15.
    Di.S.Sal. Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.
    Although neurosyphilis (NS) keeps plaguing worldwide, often with oligosymptomatic and atypical manifestations, the most recent reports fail to provide useful information, like details of the clinical history and even of the previous early therapy. We conducted a survey of the literature of the last 5 years on the clinical presentation of NS, recording the aforementioned inaccuracies. One hundred and thirty-seven articles were collected, reporting on 286 patients. Read More

    Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes.
    Korean J Ophthalmol 2016 Oct 29;30(5):360-368. Epub 2016 Sep 29.
    Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.
    Purpose: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection.

    Methods: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Read More

    Acute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis.
    Clin Exp Optom 2017 May 31;100(3):208-213. Epub 2016 Aug 31.
    Department of Veterans Affairs, Ocala, Florida, USA.
    Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Read More

    [Atypical acute syphilitic posterior placoid chorioretinitis].
    Ophthalmologe 2017 Jun;114(6):563-566
    Augenklinik, Semmelweis Universität, Mária Str. 39, 1085, Budapest, Ungarn.
    Syphilis is an infectious disease that can cause a wide variety of ocular signs. One of the rarest manifestations of ocular syphilis is acute syphilitic posterior placoid chorioretinitis (ASPPC). We report the case of an immunocompetent 38-year-old woman diagnosed with unilateral, atypical, acute syphilitic posterior placoid chorioretinitis. Read More

    Don't Forget What You Can't See: A Case of Ocular Syphilis.
    West J Emerg Med 2016 Jul 21;17(4):473-6. Epub 2016 Jun 21.
    University of Texas, Health Science Center, San Antonio, Department of Emergency Medicine, San Antonio, Texas.
    This case describes an emergency department (ED) presentation of ocular syphilis in a human immunodeficiency virus (HIV) infected patient. This is an unusual presentation of syphilis and one that emergency physicians should be aware of. The prevalence of syphilis has reached epidemic proportions since 2001 with occurrences primarily among men who have sex with men (MSM). Read More

    Molecular Typing of Treponema pallidum in Ocular Syphilis.
    Sex Transm Dis 2016 08;43(8):524-7
    From the *Centers for Disease Control and Prevention, Atlanta, GA; †Department of Neurology, and ‡Department of Medicine (Infectious Diseases), University of Washington School of Medicine, Seattle, WA.
    Background: Syphilis can have many clinical manifestations, including eye involvement, or "ocular syphilis." In 2015, an increase in reported cases of ocular syphilis and potential case clusters raised concern for an oculotropic strain of Treponema pallidum, the infectious agent of syphilis. Molecular typing was used to examine strains found in cases of ocular syphilis in the United States. Read More

    Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients.
    BMC Infect Dis 2016 06 6;16:245. Epub 2016 Jun 6.
    Department of Dermatology, Shanghai Xuhui Central Hospital, Shanghai, People's Republic of China.
    Background: Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients.

    Methods: The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed. Read More

    [Ocular Manifestations in Sarcoidosis].
    Klin Monbl Augenheilkd 2016 May 17;233(5):594-600. Epub 2016 May 17.
    Augenabteilung, St. Franziskus-Hospital Münster.
    Sarcoidosis is an inflammatory multi-organ disease of unknown pathogenesis, characterised by non-necrotising granulomata. Sarcoidosis predominantly manifests in the lung, but any other organ may be affected. Ocular involvement is present in about 25 to 50 % of patients. Read More

    Syphilitic placoid chorioretinitis. A case-report.
    Arch Soc Esp Oftalmol 2016 May 23;91(5):232-5. Epub 2016 Feb 23.
    Servicio de Oftalmología, Hospital Universitario de León, León, España; Instituto de Biomedicina (IBIOMED), Universidad de León, León, España.
    Clinical Case: We report the case of a 45-year-old woman, with unremarkable past medical history, who presented with acute visual loss in her left eye due to bilateral posterior uveitis. After the screening, she was diagnosed with acute syphilitic placoid chorioretinitis and was treated with intravenous penicillin.

    Discussion: Clinical manifestations of ocular syphilis are extremely heterogeneous and may mimic several aetiologies. Read More

    [Ocular manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus].
    Zhonghua Yan Ke Za Zhi 2015 Oct;51(10):739-45
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China; Email:
    Objective: To investigate the clinical manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus (HIV).

    Methods: Uveoretinitis patients presenting between January 2008 and December 2014 at Eye and ENT Hospital of Fudan University were collected. Patients were selected with positive serologic tests, including rapid plasma regain titer (RPR) > 1:8, treponema pallidum particle agglutination assay (TPPA) and human immunodeficiency virus (HIV). Read More

    [Ocular syphilis: A retrospective study of 27 cases in Nantes University Hospital (France) from 2000 to 2013].
    Rev Med Interne 2015 Nov 19;36(11):722-7. Epub 2015 Sep 19.
    Service d'ophtalmologie, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.
    Introduction: Syphilis may manifest as several distinct ophthalmological forms. The main objective of our study was to describe the diagnostic, therapeutic data and prognosis of ocular syphilis.

    Patients And Methods: We retrospectively analysed the cases of syphilitic uveitis diagnosed in the University Hospital of Nantes between 2000 and 2013. Read More

    Clinical and laboratory characteristics of ocular syphilis: a new face in the era of HIV co-infection.
    J Ophthalmic Inflamm Infect 2015 Dec 22;5(1):56. Epub 2015 Aug 22.
    Department of Ophthalmology, USC Eye Institute, Keck School of Medicine of the University of Southern California, 1450 San Pablo St., Suite 4000, Los Angeles, CA, 90033, USA,
    Background: Ocular syphilis is reemerging as an important cause of uveitis in the new era of common co-infection with HIV. This study will reveal the clinical and laboratory characteristics in the group of individuals co-infected with ocular syphilis and HIV compared with HIV-negative individuals. In this retrospective observational case series, medical records of patients diagnosed with ocular syphilis with serologic support from 2008 to 2014 were reviewed. Read More

    Ocular syphilis: an alarming infectious eye disease.
    Int J Clin Exp Med 2015 15;8(5):7770-7. Epub 2015 May 15.
    Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, P. R. China.
    Background: To describe the clinical manifestations and ancillary examination outcomes of ocular syphilis in Southeast China.

    Materials And Methods: This is a retrospective, nonrandom case study. Demographic information, serum and cerebrospinal fluid (CSF) test results, and findings of fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and spectral domain optical coherence tomography (SD-OCT) were analyzed. Read More

    Syphilitic uveitis and optic neuritis in Sydney, Australia.
    Br J Ophthalmol 2015 Sep 18;99(9):1215-9. Epub 2015 Mar 18.
    Save Sight Institute, Discipline of Ophthalmology, Sydney Eye Hospital Campus, The University of Sydney, Sydney, Australia.
    Aims: To describe ocular syphilis presentations to a tertiary referral eye hospital over a 5-year period and to document HIV coinfection frequency.

    Methods: A retrospective chart review was conducted of consecutive ocular syphilis presentations to Sydney Eye Hospital from 2007 to 2012. Inclusion criteria were positive syphilis serology, ocular inflammation on clinical examination and appropriate syphilis treatment. Read More

    [Clinical and paraclinical features of syphilitic uveitis].
    J Fr Ophtalmol 2015 Mar 28;38(3):220-8. Epub 2015 Jan 28.
    Service d'ophtalmologie, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003, Lyon, France.
    Introduction: Syphilis, caused by Treponema pallidum agent, results in polymorphic and non-specific ocular manifestations. Early diagnosis and institution of individualized treatment play a large role in the prognosis. The increase in syphilis over the past several years requires the ophthalmologist to consider this diagnosis in the setting of any intraocular inflammatory involvement. Read More

    Ocular syphilis.
    Curr Opin Ophthalmol 2014 Nov;25(6):513-8
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
    Purpose Of Review: Review current literature relevant to syphilitic uveitis utilizing Medline search and online governmental resources relevant to the diagnosis and management of syphilis presenting with ocular manifestations.

    Recent Findings: There is a trend for increasing frequency of primary and secondary syphilis in developed countries, especially in young men. Ocular manifestations of syphilis are rare, occurring in less than one in 1 million persons in the United Kingdom. Read More

    Granulomatous disease in the head and neck: developing a differential diagnosis.
    Radiographics 2014 Sep-Oct;34(5):1240-56
    From the Departments of Radiology (O.K.N., R.N., A.F., O.S.) and Otolaryngology-Head and Neck Surgery (O.S.), Boston Medical Center, Boston University School of Medicine, 820 Harrison Ave, Boston, MA 02118.
    Granulomatous diseases have a varied etiology that includes autoimmune, infectious, idiopathic, and hereditary causes. The unifying factor in these diseases is the formation of granulomas, which histologically are mononuclear inflammatory cells or macrophages surrounded by lymphocytes. Granulomatous diseases often have systemic manifestations that affect organs throughout the body. Read More

    [Ocular syphilis].
    J Fr Ophtalmol 2014 Apr 18;37(4):329-36. Epub 2014 Mar 18.
    Clinique universitaire d'ophtalmologie, CHU de Grenoble, université J.-Fourier, BP 217, 38043 Grenoble cedex 09, France.
    Syphilis is a sexually transmitted disease caused by Treponema pallidum. Previously known as the "great imitator", this disease can have numerous and complex manifestations. The ophthalmologist should suspect the diagnosis in patients with uveitis or optic neuropathy and high-risk sexual behavior and/or another sexually transmitted disease (such as HIV) or those presenting with posterior placoid chorioretinitis or necrotising retinitis. Read More

    Neurological Findings in Early Syphilis: a Comparison Between HIV Positive and Negative Patients.
    Neurol Int 2013 11;5(4):e19. Epub 2013 Nov 11.
    Central Military Hospital , Mexico City, Mexico.
    After a decade of steady decline, syphilis has reemerged within the past few years and it is seeping back into the HIV negative population. We describe herein 16 consecutive cases of neurosyphilis and compare its clinical characteristics. Of the 16 patients, 14 (87%) were men. Read More

    Syphilitic uveitis in a Singaporean population.
    Ocul Immunol Inflamm 2014 Feb 24;22(1):9-14. Epub 2013 Sep 24.
    Yong Loo Lin School of Medicine, National University of Singapore , Singapore .
    Purpose: To report the presentations of syphilitic uveitides in Singapore.

    Methods: Retrospective noncomparative observational case series of 18 eyes from 12 patients with ocular syphilis between 2004 and 2009.

    Results: Patients were mainly male (91. Read More

    Uveitis and desquamating rash of the palms and soles.
    Am J Dermatopathol 2013 Jun;35(4):494-5
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9190, USA.
    Syphilis, a sexually transmitted disease caused by the spirochete Treponema pallidum, can affect nearly every organ system in the body. In particular, skin manifestations of secondary syphilis are common but nonspecific and can be a true masquerader of other skin disorders. Concomitant infection with HIV has been increasing and may cause even more unusual skin presentations. Read More

    [Cogan syndrome].
    Presse Med 2013 Jun 13;42(6 Pt 1):951-60. Epub 2013 Mar 13.
    Centre hospitalier de Valence, département de médecine interne, France.
    Cogan's syndrome is a rare disorder of unknown origin characterized by inflammatory ocular disease (mainly interstitial keratitis) and audiovestibular symptoms (mainly acute-onset sensorineural hearing loss) in the setting of a negative work-up for syphilis. The diversity of the ocular and audiovestibular manifestations reported in the literature in atypical Cogan's syndrome should make one cautious before accepting the diagnosis as the disease may mimic various other systemic disorders. Systemic corticosteroids are always the most widely used and successful therapy. Read More

    Ocular syphilis, a case of acute posterior placoid chorioretinitis.
    Bull Soc Belge Ophtalmol 2013 (322):21-5
    Purpose: To report a case of acute posterior placoid chorioretinitis, a rare manifestation of ocular syphilis.

    Methods: The patient was examined at age 59 with symptoms of subacute severe unilateral vision loss of the right eye. He underwent fundus examination, automated perimetry, optical coherence tomography imaging and fluorescein angiography. Read More

    Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature.
    Retina 2012 Oct;32(9):1915-41
    The LuEsther T. Mertz Retina Research Center of Manhattan Eye, Ear and Throat Hospital, New York, New York, USA.
    Purpose: To describe the clinical and angiographic features of a series of patients with acute syphilitic posterior placoid chorioretinitis (ASPPC) in the context of previously published cases.

    Methods: A retrospective, noncomparative, multicenter chart review was performed on 16 patients with active ASPPC. Positive serologic tests supported the diagnosis in all patients. Read More

    [Nonspecific altitudinal scotoma].
    Ophthalmologe 2012 Jun;109(6):600-2
    Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes, Kirrbergerstraße, 66424, Homburg, Deutschland.
    Syphilis is a sexually transmitted, chronic, systemic infection caused by the spirochete Treponema pallidum. If left untreated the disease progresses through 3 stages. The ocular manifestations are highly variable, including interstitial keratitis, anterior, intermediate and posterior uveitis, chorioretinitis, retinitis, retinal vasculitis and optic neuropathy which can occur at all stages. Read More

    Shared care approach to managing ophthalmological disease in patients with positive treponemal serology: a case series.
    Int J STD AIDS 2012 Apr;23(4):291-6
    Bristol Sexual Health Centre, University of Bristol, Bristol, UK.
    Ocular syphilis presenting initially as various manifestations of intraocular inflammation is a rare but an important manifestation of syphilis. Ocular phenotypes are varied and mimic other infectious and non-infectious ocular diseases. Uncertainties exist in optimal management of ocular manifestations of syphilis due to a lack of evidence from randomized controlled trials. Read More

    Ocular manifestations of syphilitic uveitis in Chinese patients.
    Retina 2012 Oct;32(9):1906-14
    Department of Ophthalmology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, PR China.
    Purpose: To present the manifestations of syphilitic uveitis in Chinese patients.

    Methods: This is a retrospective case series of 35 eyes of 19 patients with syphilitic uveitis. The data of these patients including complaints, ocular and systemic manifestations, human immunodeficiency virus status, results of auxiliary examinations, treatment, and follow-up were reviewed. Read More

    Fluorescein and indocyanine-green angiography in ocular syphilis: an exploratory study.
    Graefes Arch Clin Exp Ophthalmol 2012 May 25;250(5):721-30. Epub 2011 Dec 25.
    Jules-Gonin Eye Hospital, University of Lausanne, Av. de France 15, CH-1004, Lausanne, Switzerland.
    Background: Fluorescein (FA) and indocyanine-green angiography (ICGA) may offer valuable information concerning disease severity and prognosis in ocular syphilis. The aim of the present study is to describe angiographic patterns encountered in the context of ocular syphilis, and to explore the associations between specific angiographic manifestations and severity of disease presentation, as well as disease evolution after treatment.

    Methods: We performed a retrospective institutional study with the inclusion of 23 patients with ocular syphilis presenting to the uveitis clinic of the Jules-Gonin Eye Hospital in a 10-year period. Read More

    Review for disease of the year: differential diagnosis of ocular toxoplasmosis.
    Ocul Immunol Inflamm 2011 Jun;19(3):171-9
    Uveitis Division, Centro Brasileiro de Ciências Visuais, Belo Horizonte, Brazil.
    The diagnosis of ocular toxoplasmosis is mainly clinical, based in the presence of focal necrotizing retinochoroiditis often associated with a preexistent chorioretinal scar, and variable involvement of the vitreous, retinal blood vessels, optic nerve, and anterior segment of the eye. Recognition of this clinical spectrum of toxoplasmic retinochoroiditis is crucial, but other infectious, noninfectious, and neoplastic entities should also be considered in the differential diagnosis. Investigations such as serological tests, polymerase chain reaction of ocular fluids, and assessment of intraocular antibody synthesis are helpful in uncertain cases. Read More

    Malignant syphilis with ocular involvement in an HIV-infected patient.
    Int J STD AIDS 2011 May;22(5):298-300
    Department of Infectious Diseases, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
    Malignant syphilis is now considered a rare disease, more commonly affecting individuals with poor health, malnutrition or HIV infection. We present a 34-year-old man with HIV infection who developed multiple atypical cutaneous ulcerations, leonine facies, a scleral nodule and keratitis with visual loss. The diagnosis of malignant syphilis was delayed due to the insidious presentation, but was confirmed via immunohistochemical (IHC) staining with anti-Treponema antibodies of a skin biopsy. Read More

    Spectral-domain optical coherence tomography features of acute syphilitic posterior placoid chorioretinitis: the role of autoimmune response in pathogenesis.
    Case Rep Ophthalmol 2011 Jan 25;2(1):39-44. Epub 2011 Jan 25.
    Department of Ophthalmology, Hospital S. João, University of Porto, Porto, Portugal.
    Purpose: Syphilis is an infectious disease that can cause a wide variety of ocular signs. One of the rarest manifestations of ocular syphilis is acute syphilitic posterior placoid chorioretinitis (ASPPC). We report on the spectral-domain optical coherence tomography (SD-OCT) features of a case diagnosed with unilateral ASPPC. Read More

    [Ocular syphilis: ten new cases and review of the literature].
    Rev Chilena Infectol 2010 Dec 7;27(6):525-32. Epub 2011 Jan 7.
    Servicio de Oftalmología, Hospital Clínico, Universidad de Chile, Santiago, Chile.
    Introduction: Ocular manifestations in patients with syphilis may involve almost any of the structures of the eye.

    Objectives: To describe ten new cases of syphilis with eye involvement and to briefly discuss the management and therapy of such condition.

    Material And Methods: Ten cases were retrospectively studied over 13 years. Read More

    Retinal vascular tortuosity in a patient with weill-marchesani syndrome.
    Case Rep Ophthalmol Med 2011 20;2011:952543. Epub 2011 Dec 20.
    Department of Ophthalmology, Whipps Cross University Hospital NHS Trust, Whipps Cross Road, Leytonstone, London E11 1NR, UK.
    Weill-Marchesani syndrome (WMS) is a rare connective tissue disorder with characteristic phenotypic skeletal and ocular manifestations. A 28-year-old myopic female presented with an 8-month history of bilateral blurred vision. On examination, she was noted to be of short stature with brachydactyly. Read More

    Syphilis consequences and implications in delayed diagnosis: five cases of secondary syphilis presenting with ocular symptoms.
    Sex Transm Infect 2010 Dec 8;86(7):512-3. Epub 2010 Nov 8.
    Department of Genitourinary Medicine and Infectious Diseases, St James's Hospital, Dublin 8, Ireland.
    Ocular manifestations of syphilis are uncommon. Five cases of ocular syphilis are presented, in four of which there was a delay in diagnosis. Four of the patients were men who have sex with men (MSM), and four patients were HIV negative. Read More

    1 OF 3