153 results match your criteria Ocular Manifestations of Syphilis


Peripheral blood mononuclear cell microRNA profiles in syphilitic patients with serofast status.

Mol Biol Rep 2020 May 24;47(5):3407-3421. Epub 2020 Apr 24.

Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Syphilis is a chronic sexually transmitted disease caused by infection with Treponema pallidum, which can invade various system organs, leading to clinical manifestations such as neurosyphilis, ocular syphilis, and cardiovascular syphilis and seriously endangering human health. Serofast status is a common outcome after syphilis treatment that presents an important clinical problem. At present, the etiology of serofast status remains unknown. Read More

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http://dx.doi.org/10.1007/s11033-020-05421-7DOI Listing
May 2020
2.024 Impact Factor

Evaluation of the level of awareness of congenital toxoplasmosis and associated practices among pregnant women and health workers in Tanzania's Temeke district in Dar es Salaam.

Afr Health Sci 2019 Dec;19(4):3027-3037

University of Zambia School of Veterinary Medicine, clinical studies.

Background: Toxoplasmosis caused by the obligate intracellular coccidian protozoan T () infects all warm-blooded animals including humans. This parasite may develop in both immune-compromised and immunocompetent hosts but usually the disease manifestations strongly differ according to immune status. Immunocompromised hosts develop more severe disease than immunocompetent hosts. Read More

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http://dx.doi.org/10.4314/ahs.v19i4.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040330PMC
December 2019

Prevalence of Self-Reported Neurologic and Ocular Symptoms in Early Syphilis Cases.

Clin Infect Dis 2020 Feb 26. Epub 2020 Feb 26.

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Neurosyphilis, a complication of syphilis, can occur at any stage of infection. Measuring the prevalence of neurosyphilis is challenging and there are limited data on the prevalence of neurologic or ocular symptoms among patients with syphilis. We sought to describe the prevalence of neurologic and/or ocular symptoms among early syphilis (ES) cases and the clinical management of symptomatic cases enrolled in the STD Surveillance Network (SSuN) Neuro/Ocular Syphilis Surveillance project. Read More

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http://dx.doi.org/10.1093/cid/ciaa180DOI Listing
February 2020

Ocular syphilis in an immunocompetent host.

IDCases 2020 26;19:e00684. Epub 2019 Dec 26.

University Of Illinois College of Medicine, Department of Medicine, Peoria, IL, USA.

Syphilis is an old disease that experienced a resurgence with the emergence of HIV/AIDS. Syphilis is a reportable infection that is monitored by the Centers for disease Control (CDC) in the U.S. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030984PMC
December 2019

Ocular Syphilis: Clinical Manifestations and Treatment Course.

WMJ 2019 Dec;118(4):191-195

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin,

Introduction: We report 3 ocular syphilis cases that highlight the increasing incidence, variable presentation, diagnostic challenges, and treatment considerations of this potentially visionthreatening disease.

Case Series: A 39-year-old woman with diabetes and intravenous (IV) drug use presented with 3 weeks of decreased vision, left-eye photopsia, and rash. A 52-year-old man who has sex with men (MSM), presented with a 1-month history of upper respiratory infection-like symptoms, right-eye scotoma, redness, headache, and muffled hearing. Read More

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December 2019

Multimodal imaging patterns of posterior syphilitic uveitis: a review of the literature, laboratory evaluation and treatment.

Int Ophthalmol 2020 May 11;40(5):1319-1329. Epub 2020 Jan 11.

Eye Institute, Cleveland Clinic Abu Dhabi, Al Maryah Island, PO Box 112412, Abu Dhabi, UAE.

Purpose: To review the multimodal imaging patterns of posterior syphilitic uveitis.

Methods: A systematic review.

Results: The percentage of syphilis has started to increase again: The World Health Organization has reported 12 million new cases of syphilis each year. Read More

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http://dx.doi.org/10.1007/s10792-020-01285-9DOI Listing

Resurgence of ocular syphilis in British Columbia between 2013-2016: a retrospective chart review.

Can J Ophthalmol 2020 Apr 27;55(2):179-184. Epub 2019 Dec 27.

British Columbia Centre for Disease Control, Vancouver, B.C.. Electronic address:

Objective: To characterize the trends and explore the demographics, ophthalmic manifestations, and outcomes of ocular syphilis cases in British Columbia.

Design: Retrospective chart review.

Participants: Ocular syphilis cases reported to the British Columbia Centre for Disease Control (BCCDC) between January 2013 and December 2016. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.11.002DOI Listing
April 2020
1.299 Impact Factor

Ocular and neurosyphilis: epidemiology and approach to management.

Authors:
Ameeta E Singh

Curr Opin Infect Dis 2020 Feb;33(1):66-72

Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Purpose Of Review: In the context of a resurgence of syphilis worldwide, it can be anticipated that a rise in cases of ocular, otic, and neurosyphilis will also be seen. This article reviews the current epidemiology, manifestations, and approach to management and treatment.

Recent Findings: Although studies continue investigating alternate approaches and new diagnostic tests for ocular and neurosyphilis, few data exist to change current diagnostic algorithms and approaches to diagnosis, management, or follow up. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000617DOI Listing
February 2020

Angiography and En Face Optical Coherence Tomography Findings in Acute Syphilitic Posterior Placoid Chorioretinopathy.

Case Rep Ophthalmol 2019 May-Aug;10(2):165-171. Epub 2019 May 23.

Uveitis Unit, Hospital Clinic de Barcelona, Instituto de Oftalmología, Facultad de Medicina, Universidad de Barcelona, Barcelona, Spain.

Acute syphilitic posterior placoid chorioretinopathy (ASPPC) is one of the rarest ocular manifestations of syphilis. The pathophysiology of this entity is still unknown. We report the outer retinal findings on en face optical coherence tomography (OCT) and the alteration of choriocapillaris flow findings on OCT angiography in a patient with ASPPC at the time of presentation, after penicillin treatment completion and during follow-up. Read More

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http://dx.doi.org/10.1159/000500239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760361PMC

Intermediate Uveitis as the Initial and Only Presentation of Syphilis

Turk J Ophthalmol 2019 Oct;49(5):297-299

University of Health Sciences, Beyoğlu Eye Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey

We report a patient with unilateral syphilitic intermediate uveitis without dermatological, neurological, or any systemic involvement. He presented to our clinic with complaints of eye floaters and worsening visual acuity in the left eye. He had intermediate uveitis and cystoid macular edema in that eye and both venereal disease research laboratory and microhemagglutination assay for serological tests were confirmatory for syphilis. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2019.72558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823590PMC
October 2019

Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis.

Ocul Immunol Inflamm 2019 Oct 24:1-7. Epub 2019 Oct 24.

Ophthalmology, CHU Saint-Pierre and Brugmann, Université Libre de Bruxelles , Brussels , Belgium.

: To evaluate neurosyphilis cerebrospinal fluid (CSF) findings and initial ophthalmic manifestations in patients with syphilitic uveitis. : We retrospectively reviewed the records of CSF analysis of 14 patients with syphilitic uveitis with treponemal analysis - chemiluminescent immunoassay and TPHA- and non-treponemal analysis - Rapid Plasma Reagin test - RPR. : 86% were males and 43% HIV+. Read More

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http://dx.doi.org/10.1080/09273948.2019.1672193DOI Listing
October 2019
1 Read

Intravitreal sustained-release dexamethasone implant for the treatment of persistent cystoid macular edema in ocular syphilis.

Indian J Ophthalmol 2019 09;67(9):1487-1490

Department of Uvea, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India.

With a resurgence of syphilis with human immunodeficiency virus (HIV) infection in last few years, various ocular manifestations of syphilis have been described in literature. This case report described an HIV-positive patient on anti-retroviral therapy who was diagnosed and treated for posterior uveitis secondary to ocular syphilis in the recent past presented to our clinic with cystoid macular edema (CME). CME, which did not respond to periocular corticosteroid, resolved with intravitreal sustained release dexamethasone implant. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1795_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727693PMC
September 2019
2 Reads

Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient.

Open Access Maced J Med Sci 2019 Jun 25;7(12):1987-1990. Epub 2019 Jun 25.

Department of Ophthalmology, Faculty of Medicine, Udayana University, Bali, Indonesia.

Background: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients.

Case Presentation: A 53-years old, bisexual, male patient whose initial presentation was a blurry vision on the left eye. Read More

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http://dx.doi.org/10.3889/oamjms.2019.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684424PMC
June 2019
3 Reads

Coexistence of Papillitis and Posterior Placoid Chorioretinopathy as the Presenting Symptoms of Syphilis-Human Immunodeficiency Virus Coinfection.

Neuroophthalmology 2019 Jun 20;43(3):196-200. Epub 2018 Jul 20.

Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey.

A 27-year-old male was presented with a decrease in vision in the left eye. Best-corrected visual acuity was 10/10 in the right eye and counting fingers at 2 m in the left eye. On fundus examination, the left optic disc was oedematous and there was a wide yellowish, well-defined placoid lesion between the temporal vascular arcades with mild vitreous inflammation. Read More

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http://dx.doi.org/10.1080/01658107.2018.1493515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619981PMC
June 2019
6 Reads

In Response To: Lapere S., Mustak H. and Steffen J. "Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis".

Ocul Immunol Inflamm 2019 25;27(6):1010-1011. Epub 2019 Apr 25.

Department of Microbiology, University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/09273948.2019.1590604DOI Listing
December 2019
5 Reads

Clinical Profile and Visual Outcomes of Ocular Syphilis: A Five-year Review in Hospital Universiti Sains, Malaysia.

Cureus 2019 Feb 5;11(2):e4015. Epub 2019 Feb 5.

Ophthalmology, Universiti Sains Malaysia, Kota Bharu, MYS.

Introduction Ocular syphilis is a sight-threatening condition. It can occur at any stage of syphilis infection, which present either with acute inflammation during the primary, secondary, and early latent stages or with chronic inflammation during tertiary infection, affecting virtually every ocular structure. This study was to report on the clinical presentation of ocular syphilis that presented to eye clinic Hospital Universiti Sains Malaysia. Read More

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http://dx.doi.org/10.7759/cureus.4015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453624PMC
February 2019
15 Reads

[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0854-3421
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http://dx.doi.org/10.1055/a-0854-3421DOI Listing
April 2019
39 Reads

[The ocular manifestations of human immunodeficiency virus and syphilis coinfection].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.008DOI Listing
April 2019
34 Reads

Presentation of Ocular Syphilis in a HIV-Positive Patient with False-Negative Serologic Screening.

Case Rep Infect Dis 2019 3;2019:8191724. Epub 2019 Feb 3.

Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ, USA.

Purpose: The ocular sequelae of syphilis are devastating and may cause blindness. The ambiguous nature of its ocular manifestations makes syphilis difficult to detect. Though uncommon, the rise of syphilis in the United States requires a renewed understanding of its ophthalmic presentation to prevent devastating outcomes. Read More

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http://dx.doi.org/10.1155/2019/8191724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377954PMC
February 2019
9 Reads

Multimodal Imaging of Atypical Acute Syphilitic Posterior Placoid Chorioretinitis Mimicking a White Dot Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2019 02;50(2):e52-e55

As rates of infectious syphilis continue to rise in the U.S., it is important to be familiar with known manifestations of ocular syphilis as well as report presentations not previously described in the literature. Read More

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http://dx.doi.org/10.3928/23258160-20190129-20DOI Listing
February 2019
6 Reads

Author Correction: Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.

Sci Rep 2018 Oct 23;8(1):15902. Epub 2018 Oct 23.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More

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http://www.nature.com/articles/s41598-018-34170-8
Publisher Site
http://dx.doi.org/10.1038/s41598-018-34170-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198005PMC
October 2018
40 Reads

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis.

Acta Ophthalmol 2019 Jun 17;97(4):e641-e647. Epub 2018 Oct 17.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Ocular manifestations of syphilis have been reported in 2-10% of systemic infection. The purpose of this study was to report the incidence of ocular syphilis and various ocular manifestations, particularly optic nerve involvement, in newly diagnosed cases.

Methods: This was a retrospective study. Read More

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http://dx.doi.org/10.1111/aos.13963DOI Listing
June 2019
13 Reads

Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis.

Ocul Immunol Inflamm 2019 19;27(1):126-130. Epub 2018 Sep 19.

a Department of Ophthalmology , Groote Schuur Hospital , Cape Town , South Africa.

Purpose: To review the clinical manifestations, cerebrospinal fluid findings and outcomes of patients diagnosed with ocular syphilis.

Methods: Retrospective case review of all patients treated with ocular syphilis at Groote Schuur Hospital in Cape Town, South Africa between January 2008 and January 2013.

Results: A total of 77 eyes of 49 patients were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
Publisher Site
http://dx.doi.org/10.1080/09273948.2018.1521436DOI Listing
January 2020
45 Reads

Ocular Manifestations of Human Immunodeficiency Virus Infection at a Tertiary Referral Center in Taiwan.

Ocul Immunol Inflamm 2019 6;27(7):1071-1076. Epub 2018 Sep 6.

Department of Ophthalmology, Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.

: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) : A retrospective cohort study in Taiwan was performed between January 2006 and July 2016. Ocular examination and systemic information were recorded from the HIV-infected patients. : 1242 patients with HIV/AIDS were identified. Read More

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http://dx.doi.org/10.1080/09273948.2018.1499939DOI Listing
April 2020
15 Reads

Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.

Sci Rep 2018 08 13;8(1):12071. Epub 2018 Aug 13.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

Recent reports from different world regions suggest ocular syphilis is re-emerging, in parallel with an increasing incidence of the systemic infection globally. We conducted a large observational study of 127 persons consecutively treated for ocular syphilis at public medical centers in Brazil over a 2.5-year period ending July 2015. Read More

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http://dx.doi.org/10.1038/s41598-018-30559-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089995PMC
August 2018
25 Reads

Specialty management differences of syphilis and toxoplasmosis surrounding pregnancy: a prospective cross-sectional study.

J Ophthalmic Inflamm Infect 2018 Jul 3;8(1):10. Epub 2018 Jul 3.

Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Court, Mail Stop F731, Aurora, CO, 80045, USA.

Background: Syphilis and toxoplasmosis are two infectious conditions that can occur during pregnancy. Both these diseases can have ocular manifestations and thus are treated by ophthalmologists and obstetricians. We hypothesized that specialty training would affect the way physicians selected therapy. Read More

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http://dx.doi.org/10.1186/s12348-018-0152-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029981PMC
July 2018
53 Reads

Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient.

Case Rep Infect Dis 2018 18;2018:2840241. Epub 2018 Feb 18.

University of Nebraska Medical Center, S. 42nd and Emile St., Omaha, NE, USA.

. is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Read More

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http://dx.doi.org/10.1155/2018/2840241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835303PMC
February 2018
20 Reads

Secondary pulmonary syphilis: Case report and review of literature.

Ann Dermatol Venereol 2018 Apr 17;145(4):278-287. Epub 2018 Feb 17.

Service de dermatologie, hôpital Emile-Muller, GHR Mulhouse-Sud Alsace, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.

Introduction: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review.

Patients And Methods: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. Read More

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http://dx.doi.org/10.1016/j.annder.2017.11.015DOI Listing
April 2018
19 Reads

Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.

Medicine (Baltimore) 2017 Oct;96(43):e8376

aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

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http://dx.doi.org/10.1097/MD.0000000000008376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671864PMC
October 2017
52 Reads

Increases in Ocular Syphilis-North Carolina, 2014-2015.

Clin Infect Dis 2017 Oct;65(10):1676-1682

North Carolina Division of Public Health, Raleigh.

Background: Ocular syphilis is an inflammatory eye disease due to Treponema pallidum infection. In the United States, syphilis rates have increased since 2000; clusters of ocular syphilis were reported in 2015. We investigated ocular syphilis in North Carolina to describe the epidemiology and clinical course of disease. Read More

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http://dx.doi.org/10.1093/cid/cix604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740484PMC
October 2017
28 Reads

Ocular syphilis masquerading as bilateral peripheral ulcerative keratitis.

Taiwan J Ophthalmol 2016 Oct-Dec;6(4):204-205. Epub 2016 Jul 16.

Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India.

Ocular syphilis has varied manifestations in the eye. Peripheral ulcerative keratitis (PUK) is a crescent-shaped ulcer involving the peripheral cornea and associated with thinning. PUK is caused by both autoimmune and infectious diseases, such as rheumatoid arthritis, tuberculosis, and herpes. Read More

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http://dx.doi.org/10.1016/j.tjo.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525632PMC
July 2016
21 Reads

[Neurosyphilis: A retrospective study of 13 cases at Strasbourg University Hospital].

J Fr Ophtalmol 2017 Oct 1;40(8):654-660. Epub 2017 Sep 1.

Laboratoire de bactériologie, CHU de Strasbourg, 67000 Strasbourg, France.

Objective: After a decade of constant decline, the number of syphilis cases has been steadily increasing since the 2000s, particularly in HIV infected patients. Neurosyphilis is a rare manifestation of this sexually transmitted disease for which we performed a retrospective study and analyzed clinical manifestations.

Patients And Methods: We reviewed retrospectively all the neurosyphilis cases admitted to Strasbourg University Hospital between 2004 and 2014. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.03.007DOI Listing
October 2017
22 Reads

Neurosyphilis in Africa: A systematic review.

PLoS Negl Trop Dis 2017 Aug 31;11(8):e0005880. Epub 2017 Aug 31.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Introduction: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597251PMC
August 2017
74 Reads

UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS.

Retin Cases Brief Rep 2020 ;14(1):35-38

Department of Neurology, Indiana University, Indianapolis, Indiana.

Purpose: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis.

Methods: A case report of a 22-year-old man with progressive unilateral vision loss.

Results: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. Read More

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http://Insights.ovid.com/crossref?an=01271216-900000000-9895
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http://dx.doi.org/10.1097/ICB.0000000000000614DOI Listing
January 2020
21 Reads

Infectious uveitis: An enigma.

Middle East Afr J Ophthalmol 2017 Jan-Mar;24(1):2-10

Department of Uvea, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Infectious uveitis accounts for majority of the cases of uveitis in developing countries. It also encompasses an array of various microorganisms and their clinical presentations. Some of these infectious uveitic entities are familiar, while others are newly emerging in the global ophthalmic world. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_252_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433124PMC
June 2017
75 Reads

Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela.

JAMA Ophthalmol 2017 05;135(5):440-445

Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland8Johns Hopkins Zika Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. Read More

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaophthalmol.2017.0561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470423PMC
May 2017
28 Reads

Uveitis as an initial manifestation of acquired immunodeficiency syndrome.

Int J STD AIDS 2017 10 15;28(12):1224-1228. Epub 2017 Feb 15.

1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a multisystem disease that can involve the human eyes. Using ophthalmic examination records from January 2006 to November 2015, we retrospectively reviewed all patients who were diagnosed with HIV/AIDS in our hospital. The study was performed at a tertiary referral center in southern Taiwan. Read More

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http://dx.doi.org/10.1177/0956462417694569DOI Listing
October 2017
46 Reads

[Clinical features of neurosyphilis with optic neuritis as an initial finding].

Zhonghua Yan Ke Za Zhi 2016 Dec;52(12):898-904

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.

To study the characteristics of neurosyphilis with optic neuritis as an initial finding. Retrospective analysis of clinical data and laboratory testing results of 16 cases (27 eyes) with optic neuritis as an initial finding of neurosyphilis from October 2010 to March 2015 in General Hospital of People's Liberation Army was made. Six-teen patients (12 males, 4 females) were collected, the median age of patients was 47 (range 33 to 65) years ,the mean age was (49. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2016.12.006DOI Listing
December 2016
11 Reads

Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015.

MMWR Morb Mortal Wkly Rep 2016 Nov 4;65(43):1185-1188. Epub 2016 Nov 4.

Ocular syphilis, a manifestation of Treponema pallidum infection, can cause a variety of ocular signs and symptoms, including eye redness, blurry vision, and vision loss. Although syphilis is nationally notifiable, ocular manifestations are not reportable to CDC. Syphilis rates have increased in the United States since 2000. Read More

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http://dx.doi.org/10.15585/mmwr.mm6543a2DOI Listing
November 2016
44 Reads

Changes in neurosyphilis presentation: a survey on 286 patients.

J Eur Acad Dermatol Venereol 2016 Nov 15;30(11):1886-1900. Epub 2016 Jun 15.

Di.S.Sal. Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa, Italy.

Although neurosyphilis (NS) keeps plaguing worldwide, often with oligosymptomatic and atypical manifestations, the most recent reports fail to provide useful information, like details of the clinical history and even of the previous early therapy. We conducted a survey of the literature of the last 5 years on the clinical presentation of NS, recording the aforementioned inaccuracies. One hundred and thirty-seven articles were collected, reporting on 286 patients. Read More

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http://dx.doi.org/10.1111/jdv.13753DOI Listing
November 2016
27 Reads

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes.

Korean J Ophthalmol 2016 Oct 29;30(5):360-368. Epub 2016 Sep 29.

Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.

Purpose: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection.

Methods: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Read More

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http://dx.doi.org/10.3341/kjo.2016.30.5.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057012PMC
October 2016
20 Reads

Necrotizing retinitis due to syphilis in a patient with AIDS.

IDCases 2016 21;6:17-9. Epub 2016 Aug 21.

Indiana University Department of Medicine, United States.

The ocular manifestations of syphilis are varied. Ocular syphilis can occur during any stage of infection and involve virtually any part of the eye. In immunocompetent individuals, the most common etiologies include syphilitic uveitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021766PMC
September 2016
21 Reads

Acute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis.

Authors:
Sanjeet K Shahi

Clin Exp Optom 2017 May 31;100(3):208-213. Epub 2016 Aug 31.

Department of Veterans Affairs, Ocala, Florida, USA.

Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Read More

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http://dx.doi.org/10.1111/cxo.12449DOI Listing
May 2017
11 Reads

[Atypical acute syphilitic posterior placoid chorioretinitis].

Ophthalmologe 2017 Jun;114(6):563-566

Augenklinik, Semmelweis Universität, Mária Str. 39, 1085, Budapest, Ungarn.

Syphilis is an infectious disease that can cause a wide variety of ocular signs. One of the rarest manifestations of ocular syphilis is acute syphilitic posterior placoid chorioretinitis (ASPPC). We report the case of an immunocompetent 38-year-old woman diagnosed with unilateral, atypical, acute syphilitic posterior placoid chorioretinitis. Read More

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http://dx.doi.org/10.1007/s00347-016-0327-4DOI Listing
June 2017
10 Reads

Don't Forget What You Can't See: A Case of Ocular Syphilis.

West J Emerg Med 2016 Jul 21;17(4):473-6. Epub 2016 Jun 21.

University of Texas, Health Science Center, San Antonio, Department of Emergency Medicine, San Antonio, Texas.

This case describes an emergency department (ED) presentation of ocular syphilis in a human immunodeficiency virus (HIV) infected patient. This is an unusual presentation of syphilis and one that emergency physicians should be aware of. The prevalence of syphilis has reached epidemic proportions since 2001 with occurrences primarily among men who have sex with men (MSM). Read More

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http://dx.doi.org/10.5811/westjem.2016.5.28933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944808PMC
July 2016
37 Reads

Molecular Typing of Treponema pallidum in Ocular Syphilis.

Sex Transm Dis 2016 08;43(8):524-7

From the *Centers for Disease Control and Prevention, Atlanta, GA; †Department of Neurology, and ‡Department of Medicine (Infectious Diseases), University of Washington School of Medicine, Seattle, WA.

Background: Syphilis can have many clinical manifestations, including eye involvement, or "ocular syphilis." In 2015, an increase in reported cases of ocular syphilis and potential case clusters raised concern for an oculotropic strain of Treponema pallidum, the infectious agent of syphilis. Molecular typing was used to examine strains found in cases of ocular syphilis in the United States. Read More

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http://pdfs.journals.lww.com/stdjournal/2016/08000/Molecular
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http://dx.doi.org/10.1097/OLQ.0000000000000478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253705PMC
August 2016
54 Reads

Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients.

BMC Infect Dis 2016 06 6;16:245. Epub 2016 Jun 6.

Department of Dermatology, Shanghai Xuhui Central Hospital, Shanghai, People's Republic of China.

Background: Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients.

Methods: The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1186/s12879-016-1586-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895961PMC
June 2016
19 Reads

[Ocular Manifestations in Sarcoidosis].

Klin Monbl Augenheilkd 2016 May 17;233(5):594-600. Epub 2016 May 17.

Augenabteilung, St. Franziskus-Hospital Münster.

Sarcoidosis is an inflammatory multi-organ disease of unknown pathogenesis, characterised by non-necrotising granulomata. Sarcoidosis predominantly manifests in the lung, but any other organ may be affected. Ocular involvement is present in about 25 to 50 % of patients. Read More

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http://dx.doi.org/10.1055/s-0042-104063DOI Listing
May 2016
15 Reads

Syphilitic placoid chorioretinitis. A case-report.

Arch Soc Esp Oftalmol 2016 May 23;91(5):232-5. Epub 2016 Feb 23.

Servicio de Oftalmología, Hospital Universitario de León, León, España; Instituto de Biomedicina (IBIOMED), Universidad de León, León, España.

Clinical Case: We report the case of a 45-year-old woman, with unremarkable past medical history, who presented with acute visual loss in her left eye due to bilateral posterior uveitis. After the screening, she was diagnosed with acute syphilitic placoid chorioretinitis and was treated with intravenous penicillin.

Discussion: Clinical manifestations of ocular syphilis are extremely heterogeneous and may mimic several aetiologies. Read More

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http://dx.doi.org/10.1016/j.oftal.2016.01.005DOI Listing
May 2016
7 Reads

[Ocular manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus].

Zhonghua Yan Ke Za Zhi 2015 Oct;51(10):739-45

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China; Email:

Objective: To investigate the clinical manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus (HIV).

Methods: Uveoretinitis patients presenting between January 2008 and December 2014 at Eye and ENT Hospital of Fudan University were collected. Patients were selected with positive serologic tests, including rapid plasma regain titer (RPR) > 1:8, treponema pallidum particle agglutination assay (TPPA) and human immunodeficiency virus (HIV). Read More

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October 2015
22 Reads