184 results match your criteria Ocular Manifestations of Syphilis

Secondary syphilis presenting with "crown of Venus" alopecia.

Proc (Bayl Univ Med Cent) 2022 27;35(4):548-549. Epub 2022 Apr 27.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Since the era of antibiotics, the frequency of secondary syphilis manifestations has declined. During the last decade, there has been a resurgence of syphilis cases. We describe a case of a 28-year-old man with various secondary syphilis symptoms including alopecia with the well-described characteristic "crown of Venus" pattern not commonly seen during this decade, as well as mucosal plaques, pustules, and palmoplantar macular rash. Read More

View Article and Full-Text PDF

Ocular Syphilis: A Case Report.

Cureus 2022 Mar 26;14(3):e23509. Epub 2022 Mar 26.

Internal Medicine, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, PRT.

Neurosyphilis refers to the involvement of the central nervous system by . Ocular syphilis can present with a range of manifestations, uveitis being the most common, and it can occur at any stage of acquired syphilis. There are multiple tests available for the diagnosis of syphilis. Read More

View Article and Full-Text PDF

Temporal trends in ocular manifestations of HIV/AIDS patients in the past 18 years in a tertiary hospital in China.

Graefes Arch Clin Exp Ophthalmol 2022 Apr 23. Epub 2022 Apr 23.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Purpose: To investigate the ocular manifestation changes in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patents in a tertiary eye clinic in China over the past 18 years.

Methods: In this retrospective cross-sectional study, 264 HIV/AIDS patients (528 eyes) were recruited at the Department of Ophthalmology, Peking Union Medical College Hospital, from 2001 to 2018. Patients underwent ophthalmic examinations, including best-corrected visual acuity (BCVA), slit-lamp microscopy, and indirect ophthalmoscopy, and completed a registration form including demographic characteristics, medical history, and immune status data. Read More

View Article and Full-Text PDF

Malignant Syphilis in a Female Patient: A Case Report and Mini-Review.

Trop Med Infect Dis 2022 Mar 8;7(3). Epub 2022 Mar 8.

Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.

Malignant syphilis (MS) is a rare form of secondary syphilis with grotesque skin lesions, systemic manifestation and life-threatening complications. This article presents a case of MS in an immunocompetent 41-year-old female, who initially manifested with a generalized nonpruritic erythematous rash and systemic symptoms. She was mistreated for generalized impetigo and hepatitis attributed to chronic alcoholism. Read More

View Article and Full-Text PDF

Ocular manifestations and full house membranous nephropathy as a rare presentation of secondary syphilis.

IDCases 2022 2;28:e01461. Epub 2022 Mar 2.

West Virginia University, Morgantown, WV, USA.

Syphilis is an often-overlooked diagnosis and without timely diagnosis and treatment, can have serious repercussions. Although its prevalence had decreased with the introduction of penicillin, it has had a resurgence over the years. Discerning the proper patient population to test for syphilis should be led by a patient's risk factors. Read More

View Article and Full-Text PDF

Acute syphilitic posterior placoid chorioretinitis: when the great mimicker cannot pretend any more; new insight of an old acquaintance.

J Ophthalmic Inflamm Infect 2022 Feb 22;12(1). Epub 2022 Feb 22.

The Eye Institute Cleveland Clinic Abu Dhabi, Al Maryah Island-Abu Dhabi, PO Box 112412, UAE.

Purpose: To review the multimodal imaging patterns of Acute Syphilitic Posterior Placoid Chorioretinitis (ASPPC).

Methods: A systematic review.

Results: Syphilis has started to attract the attention of researchers once again due to recent surges, with The World Health Organization (WHO) reporting around 12 million new cases per year. Read More

View Article and Full-Text PDF
February 2022

A Case of Neurosyphilis and Review of Manifestations, Diagnosis, and Treatment.

R I Med J (2013) 2022 Feb 1;105(1):9-11. Epub 2022 Feb 1.

Kent Hospital/Dept. of Infectious Diseases.

Diagnosis of neurosyphilis remains a challenge due to no existing standardized testing, but it is often made based on a combination of clinical and cerebrospinal fluid (CSF) analysis findings. Neurosyphilis is uncommon now compared to the era before the introduction of penicillin. Syphilis if left untreated may lead to debilitating complications including paresis, progressive dementia, and even death. Read More

View Article and Full-Text PDF
February 2022

Appraisal of vitreous syphilis antibody as a novel biomarker for the diagnosis of syphilitic uveitis: a prospective case-control study.

Eye (Lond) 2022 Jan 16. Epub 2022 Jan 16.

Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA.

Purpose: To determine the sensitivity and specificity of syphilis antibody tests in vitreous samples and to propose an algorithm using vitreous syphilis antibody as a supplementary test to confirm syphilitic uveitis (SU).

Methods: A prospective case-control study was conducted at the Retina and Uveitis Clinic from May 2017 to January 2020. Initially, patients were classified based on syphilis serology into group 1 (positive testing) and group 2 (negative testing). Read More

View Article and Full-Text PDF
January 2022

Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV.

Case Rep Infect Dis 2021 15;2021:1124033. Epub 2021 Nov 15.

Robert Wood Johnson Medical School, 125 Paterson St, New Brunswick, NJ 08901, USA.

Background: An estimated 25% of primary and secondary syphilis, a sexually transmitted infection caused by the spirochete bacterium , occurs in patients coinfected with human immunodeficiency virus (HIV) (Chesson et al., 2005). This association is especially evident in men who have sex with men (MSM). Read More

View Article and Full-Text PDF
November 2021

[Research progress of ocular manifestations and treatments of human immunodeficiency virus and syphilis co-infection].

H Y Zhou J J Ye

Zhonghua Yan Ke Za Zhi 2021 Nov;57(11):865-870

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China.

Acquired immune deficiency syndrome caused by human immunodeficiency virus (HIV) infection is a fatal disease involving multiple systems. Syphilis is a systemic chronic infection disease caused by treponema pallidum infection. In recent years, the incidence of the two infectious diseases in China has been on the rise. Read More

View Article and Full-Text PDF
November 2021

[Ocular syphilis, the rise of a forgotten disease: Retrospective study of 18 cases diagnosed at Amiens University Hospital].

J Fr Ophtalmol 2021 Dec 1;44(10):1566-1575. Epub 2021 Nov 1.

Service d'ophtalmologie, CHU Amiens-Picardie, 1, rond-point du Professeur-Christian-Cabrol, 80054 Amiens, France. Electronic address:

Objectives: A disturbing resurgence of syphilis has been observed in the past few years. Ocular involvement of syphilis is infrequent. The goal of our study was to analyze the demographic data and clinical features and to analyze visual outcomes in cases of ocular syphilis at Amiens UH between January 1, 2015 and December 31, 2019. Read More

View Article and Full-Text PDF
December 2021

Spectrum of ocular manifestations and visual outcomes of neurosyphilis among 53 patients.

Arq Neuropsiquiatr 2021 07;79(7):584-589

Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Belo Horizonte MG, Brazil.

Background: In the era of the re-emergence of syphilis, ocular syphilis has gained attention because its prevalence has increased and it can cause blindness and disability.

Objectives: To investigate the clinical presentation and prognosis of ocular syphilis.

Methods: Prospective study on 53 patients (90 eyes) with ocular syphilis diagnosed at the Santa Casa of Belo Horizonte, Brazil. Read More

View Article and Full-Text PDF

Ocular syphilis.

Surv Ophthalmol 2022 Mar-Apr;67(2):440-462. Epub 2021 Jun 18.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

Multiple studies around the world suggest that syphilis is re-emerging. Ocular syphilis - with a wide range of presentations, most of which are subtypes of uveitis - has become an increasingly common cause of ocular inflammation over the past 20 years. Its rising incidence, diagnostic complexity, and manifestations that have only recently been characterized make ocular syphilis relevant from the public health, clinical, and scientific perspectives. Read More

View Article and Full-Text PDF

Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis.

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

View Article and Full-Text PDF

The Clinical Spectrum and Outcome of Uveomeningitis: A Comprehensive Analysis of 110 Cases.

Ocul Immunol Inflamm 2021 May 11:1-6. Epub 2021 May 11.

Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, APHP-Centre Université de Paris (CUP), Paris, France.

Uveitis can be associated with meningitis (uveomeningitis) and the inflammation shared with the central nervous system. We aimed to describe the characteristics and outcome of uveomeningitis. We retrospectively analyzed 110 consecutive adult patients with uveomeningitis. Read More

View Article and Full-Text PDF

Ocular syphilis - a case series of four patients.

J Dtsch Dermatol Ges 2021 Jul 5;19(7):987-991. Epub 2021 May 5.

University Hospital and Clinic for Dermatology and Venereology, University Hospital Halle (Saale) of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Read More

View Article and Full-Text PDF

Diffuse Bilateral Subacute Placoid Chorioretinitis and Hot Optic Disc as Part of Ocular Manifestations of Neurosyphilis: A Case Report.

Klin Monbl Augenheilkd 2021 04 30;238(4):434-436. Epub 2021 Apr 30.

Department of Ophthalmology (Chairman Prof. Dr. med. Ch. Valmaggia), Kantonsspital St Gallen, Sankt Gallen, Switzerland.

View Article and Full-Text PDF

Ocular syphilis.

Clin Exp Optom 2021 09 8;104(7):756-759. Epub 2021 Apr 8.

Department of Optometry, Northwest Permanente-Kaiser Permanente, Portland, OR, USA.

Syphilis is a sexually transmitted, systemic, inflammatory disease caused by the spirochaete, . The natural history of untreated syphilis progresses through four distinct stages: primary, secondary, latent, and tertiary syphilis. Ocular involvement can occur at any stage of syphilis and any part of the eye can be affected. Read More

View Article and Full-Text PDF
September 2021

Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis.

Trop Doct 2021 Jul 28;51(3):444-446. Epub 2021 Mar 28.

Department of Ophthalmology, 214250Army College of Medical Sciences & Base Hospital, Delhi, India.

Syphilis has a wide variety of ocular presentations such as anterior or posterior uveitis, chorioretinitis, retinal vasculitis, retinitis, perineuritis, papillitis, retrobulbar neuritis, optic atrophy and optic nerve gumma. Therefore, it is recommended to test every patient with ocular inflammation for syphilis. It is, however, a relatively rare cause of uveitis in HIV disease. Read More

View Article and Full-Text PDF

Ocular Findings in Infants with Congenital Toxoplasmosis after a Toxoplasmosis Outbreak.

Ophthalmology 2021 09 10;128(9):1346-1355. Epub 2021 Mar 10.

Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, SP, Brazil; Vision Institute, São Paulo, SP, Brazil.

Purpose: We investigated the prevalence of ocular abnormalities in infants vertically exposed to Toxoplasma gondii infection during an outbreak in Santa Maria City, Brazil.

Design: Consecutive case series.

Participants: A total of 187 infants were included. Read More

View Article and Full-Text PDF
September 2021

Nodular syphilitic scleritis: a rare and forgotten entity.

Int J STD AIDS 2021 07 18;32(8):766-767. Epub 2021 Feb 18.

Department of Dermatology, Venerology, Leprosy, 29099Bangalore Medical College and Research Institute, India.

Ocular manifestations of syphilis are usually seen in the secondary or tertiary stages of the disease, which is a nonspecific inflammatory response. We report a case of unilateral nodular scleritis in a patient with late latent syphilis, which resolved with intravenous crystalline penicillin for 2 weeks, topical fluorometholone, and tobramycin eye drops for 3 weeks. Read More

View Article and Full-Text PDF

[Ocular manifestations of congenital syphilis. A case report].

A Hamma A Idder

J Fr Ophtalmol 2021 Mar 29;44(3):e149-e151. Epub 2020 Dec 29.

Université d'Oran, Oran, Algérie.

View Article and Full-Text PDF

Ocular Syphilis Presenting as Acute Necrotizing Retinitis in a Human Immunodeficiency Virus-Positive Patient.

J Glob Infect Dis 2020 Jul-Sep;12(3):149-151. Epub 2020 Aug 29.

Department of Ophthalmology, AIIMS, Bhubaneswar, Odisha, India.

The incidence of ocular syphilis is increasing in the developing world even in the era of effective human immunodeficiency virus (HIV) treatment, as there is a potential increase of high-risk sexual behavior. Ocular involvement in the form of uveitis is seen in all stages of syphilis. Diagnosis begins with ophthalmologic examination, but requires serologic testing for confirmation. Read More

View Article and Full-Text PDF

Utility of Treponemal Testing from Aqueous Fluid in the Diagnosis of Ocular Syphilis in Patients with HIV/AIDS.

Ocul Immunol Inflamm 2022 Feb 5;30(2):444-450. Epub 2020 Oct 5.

L & T Microbiology Research Centre, Sankara Nethralaya, Chennai, India.

Purpose: Ocular syphilis is re-emerging globally especially in patients with human immunodeficiency virus (HIV). Atypical manifestations of ocular syphilis and/or other associated opportunistic infections often lead to a diagnostic dilemma. We evaluated the utility of aqueous humor (AH) hemagglutination assay (TPHA) titers in the diagnosis of ocular syphilis. Read More

View Article and Full-Text PDF
February 2022

Acute syphilitic posterior placoid chorioretinopathy presenting as atypical multiple evanescent white dot syndrome.

Eur J Ophthalmol 2021 Mar 2;31(2):NP141-NP144. Epub 2020 Sep 2.

Fondation Ophtalmologique Adolphe de Rothschild, Service du Professeur Sahel, Paris, France.

Background: This paper reports the case of a young man who presented with syphilis masquerading as multiple evanescent white dots syndrome (MEWDS), which turned out to be an acute syphilitic posterior placoid chorioretinopathy (ASPPC) during follow-up.

Case Presentation: A 59-year-old healthy male consulted for a three days' history of visual impairment in both eyes. On multimodal imaging, he was diagnosed as MEWDS. Read More

View Article and Full-Text PDF

Ocular syphilis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy.

Indian J Ophthalmol 2020 Sep;68(9):1887-1893

Department of Uveitis, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: Re-emergent ocular syphilis in patients with Human immunodeficiency virus (HIV) co-infection has both diagnostic and management difficulties because of the overlapping risk factors. The clinical manifestations described in non-HIV may not be the same in patients with HIV coinfection. Immune recovery uveitis (IRU) may also alter the course of the disease causing recurrences. Read More

View Article and Full-Text PDF
September 2020

Clinical manifestations and outcomes of ocular syphilis in Asian Indian population: Analysis of cases presenting to a tertiary referral center.

Indian J Ophthalmol 2020 Sep;68(9):1881-1886

Smt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.

Purpose: To describe disease manifestations and outcomes of ocular syphilis in Asian Indian population.

Methods: Retrospective analysis of patients diagnosed with ocular syphilis at a tertiary referral center in India. Demographics, history, extraocular and ocular manifestations, ocular and systemic investigations, treatment and visual acuity outcomes were noted. Read More

View Article and Full-Text PDF
September 2020

Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.

Indian J Ophthalmol 2020 Sep;68(9):1787-1798

Department of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School; Schepens Eye Research Institute, Boston, Massachusetts, USA; MCM Eye Unit, MyungSung Christian Medical Center (MCM) General Hospital and MyungSung Medical College, Addis Ababa, Ethiopia.

Intraocular inflammation in patients with human immunodeficiency virus (HIV) infection is commonly due to infectious uveitis. Ocular lesions due to opportunistic infections (OI) are the most common and have been described extensively in the pre highly active antiretroviral therapy (HAART) era. Many eye lesions were classified as acquired immunodeficiency syndrome (AIDS) defining illnesses. Read More

View Article and Full-Text PDF
September 2020

Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals.

Ocul Immunol Inflamm 2020 Oct 13;28(7):1040-1048. Epub 2020 Jul 13.

Department of Ophthalmology and Otolaryngology, Faculdade de Medicina da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.

Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphilis in HIV-infected and -uninfected patients remains with some controversy due to unspecific clinical manifestations and limited diagnostic tests. Read More

View Article and Full-Text PDF
October 2020