310 results match your criteria Ocular Manifestations of HIV


Cytomegalovirus-Immune Recovery Retinitis After Initiation of Highly Active Antiretroviral Therapy: A Case Series.

Front Med (Lausanne) 2022 27;9:807013. Epub 2022 Apr 27.

Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China.

Purpose: To delineate the characteristics and treatment of cytomegalovirus-immune recovery retinitis (CMV-IRR) in human immunodeficiency virus (HIV) patients with immune recovery under effective highly active antiretroviral therapy (HAART) regimen.

Methods: We reported four patients with HIV who were diagnosed with CMV-IRR soon after effective HAART. Plasma levels of CD4 T cells, HAART regimen, and other clinical and laboratory characteristics of the four patients were described. Read More

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Sociodemographic predictors associated with the spectrum of non-opportunist neuroretinal disease of non-infectious etiology in patients with HIV/AIDS: A scoping review.

Arch Soc Esp Oftalmol (Engl Ed) 2022 May 8;97(5):251-263. Epub 2021 Dec 8.

Fundación Oftalmológica de Santander - FOSCAL, Santander, Colombia; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: Non-infectious retinal disease, even in the HAART era, continues to be one of the most common diagnoses in patients with HIV, with prevalences of up to 27% of cases. This study aims to characterize the association between demographic variables and their role. As a risk factor for the development of non-opportunistic non-infectious retinal disease in patients with HIV/AIDS. Read More

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Physical Examination in Human Immunodeficiency Virus Disease.

Med Clin North Am 2022 May 4;106(3):527-536. Epub 2022 Apr 4.

University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address:

Human immunodeficiency virus (HIV)-associated disease is known for its protean manifestations. However, many of the characteristic findings on physical examination are not associated with HIV infection per se but the numerous opportunistic infections (OIs) that are common in patients with advanced HIV disease. Common findings of acute HIV infection include fever, adenopathy, rash, and oral ulcers. Read More

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Temporal trends in ocular manifestations of HIV/AIDS patients in the past 18 years in a tertiary hospital in China.

Graefes Arch Clin Exp Ophthalmol 2022 Apr 23. Epub 2022 Apr 23.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Purpose: To investigate the ocular manifestation changes in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patents in a tertiary eye clinic in China over the past 18 years.

Methods: In this retrospective cross-sectional study, 264 HIV/AIDS patients (528 eyes) were recruited at the Department of Ophthalmology, Peking Union Medical College Hospital, from 2001 to 2018. Patients underwent ophthalmic examinations, including best-corrected visual acuity (BCVA), slit-lamp microscopy, and indirect ophthalmoscopy, and completed a registration form including demographic characteristics, medical history, and immune status data. Read More

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Human immune deficiency virus conundrum: An everlasting challenge!

Oman J Ophthalmol 2022 Jan-Apr;15(1):13-19. Epub 2022 Mar 2.

Department of Ophthalmology, SP Medical College, Bikaner, Rajasthan, India.

Background: Human immune deficiency virus (HIV) causes a wide spectrum of diseases worldwide and has the capability to affect every organ system in the body. Ocular manifestations have been reported in up to 70% of individuals infected with HIV and the ocular manifestations reflect systemic disease and maybe the first sign of disseminated infection.

Purpose: To study the pattern of ocular manifestations related to HIV in seropositive patients with the objective of identifying its spectrum in highly active antiretroviral therapy (HAART) era and to emphasize on the role of ophthalmologists in fighting the battle against HIV. Read More

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Ocular manifestations and full house membranous nephropathy as a rare presentation of secondary syphilis.

IDCases 2022 2;28:e01461. Epub 2022 Mar 2.

West Virginia University, Morgantown, WV, USA.

Syphilis is an often-overlooked diagnosis and without timely diagnosis and treatment, can have serious repercussions. Although its prevalence had decreased with the introduction of penicillin, it has had a resurgence over the years. Discerning the proper patient population to test for syphilis should be led by a patient's risk factors. Read More

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[Ocular manifestations associated to CD4+ in patients with human immunodeficiency virus].

Rev Med Inst Mex Seguro Soc 2021 Sep 1;59(5):417-422. Epub 2021 Sep 1.

Instituto Mexicano del Seguro Social, Centro Médico Nacional de Occidente, Hospital de Especialidades "Lic. Ignacio García Téllez", Servicio de Oftalmología. Guadalajara, Jalisco, México.

Background: Since the first cases of human immunodeficiency virus (HIV), ocular manifestations secondary to infection have been known and these have been related to the CD4+ lymphocyte count.

Objective: To describe the correlation between ocular manifestations in patients with HIV and the CD4+ lymphocyte count.

Material And Methods: Analytical cross-sectional study of patients with HIV whose CD4+ count was correlated with the presence of ophthalmological manifestations. Read More

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September 2021

Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV.

Case Rep Infect Dis 2021 15;2021:1124033. Epub 2021 Nov 15.

Robert Wood Johnson Medical School, 125 Paterson St, New Brunswick, NJ 08901, USA.

Background: An estimated 25% of primary and secondary syphilis, a sexually transmitted infection caused by the spirochete bacterium , occurs in patients coinfected with human immunodeficiency virus (HIV) (Chesson et al., 2005). This association is especially evident in men who have sex with men (MSM). Read More

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November 2021

[Research progress of ocular manifestations and treatments of human immunodeficiency virus and syphilis co-infection].

Authors:
H Y Zhou J J Ye

Zhonghua Yan Ke Za Zhi 2021 Nov;57(11):865-870

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China.

Acquired immune deficiency syndrome caused by human immunodeficiency virus (HIV) infection is a fatal disease involving multiple systems. Syphilis is a systemic chronic infection disease caused by treponema pallidum infection. In recent years, the incidence of the two infectious diseases in China has been on the rise. Read More

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November 2021

[Ocular syphilis, the rise of a forgotten disease: Retrospective study of 18 cases diagnosed at Amiens University Hospital].

J Fr Ophtalmol 2021 Dec 1;44(10):1566-1575. Epub 2021 Nov 1.

Service d'ophtalmologie, CHU Amiens-Picardie, 1, rond-point du Professeur-Christian-Cabrol, 80054 Amiens, France. Electronic address:

Objectives: A disturbing resurgence of syphilis has been observed in the past few years. Ocular involvement of syphilis is infrequent. The goal of our study was to analyze the demographic data and clinical features and to analyze visual outcomes in cases of ocular syphilis at Amiens UH between January 1, 2015 and December 31, 2019. Read More

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December 2021

Unusual Presentation of Relapsing Polychondritis in a Patient with Human Immunodeficiency Virus and Reactive Arthritis.

Am J Case Rep 2021 Sep 28;22:e933327. Epub 2021 Sep 28.

Department of Rheumatology, Jersey Shore University Medical Center, Neptune, NJ, USA.

BACKGROUND Relapsing polychondritis (RP) is an uncommon autoimmune condition that impacts cartilaginous structures involving the ears, nose, respiratory tract, and joints. Its etiology is unknown; however, it may be associated with other systemic autoimmune diseases, malignancy, and rarely with human immunodeficiency virus (HIV) infection. RP has a variable pattern at presentation and may be associated with constitutional symptoms such as fever and arthralgia, in addition to various auricular, ocular, respiratory, and cardiovascular manifestations. Read More

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September 2021

Spectrum of ocular manifestations and visual outcomes of neurosyphilis among 53 patients.

Arq Neuropsiquiatr 2021 07;79(7):584-589

Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Belo Horizonte MG, Brazil.

Background: In the era of the re-emergence of syphilis, ocular syphilis has gained attention because its prevalence has increased and it can cause blindness and disability.

Objectives: To investigate the clinical presentation and prognosis of ocular syphilis.

Methods: Prospective study on 53 patients (90 eyes) with ocular syphilis diagnosed at the Santa Casa of Belo Horizonte, Brazil. Read More

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New Insights into Ocular Complications of Human Immunodeficiency Virus Infection.

Curr HIV Res 2021 ;19(6):476-487

Department of Ophthalmology, Huashan Hospital, Fudan University, 12, Middle Urumqi Road, Shanghai, 200040, China.

HIV/AIDS continues to be a major global public health issue, affecting multiple organs, such as the eyes. With the advent of Highly Active Antiretroviral Therapy (HAART), the incidence has dropped but HIV ocular complications still remain a major cause of vision impairment in HIVpositive individuals. Since modern medical interventions nowadays can change this previously fatal infection into a chronic disease and enable people living with HIV for relatively long and healthy lives, recent studies update the incidence of HIV-related ocular manifestations, which has reached 70% among HIV patients. Read More

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Ocular manifestations and refractive errors among people living with HIV in Pune, India: a cross-sectional study.

J Int Med Res 2021 Jul;49(7):3000605211026814

ICMR-National AIDS Research Institute, Pune, India.

Objective: We aimed to determine the ocular manifestation and refractive error prevalences among people living with HIV (PLHIV) in Pune, India.

Methods: This cross-sectional study included HIV-infected adults attending a National AIDS Research Institute clinic. Ophthalmologic examination included visual acuity estimation, refraction, orthoptic evaluation, slit lamp and fundus examination, and photography. Read More

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Presumed cytomegalovirus retinitis in a non-immune compromised patient with breast carcinoma during treatment: A case report.

Am J Ophthalmol Case Rep 2021 Sep 7;23:101161. Epub 2021 Jul 7.

Department of Ophthalmology, Kaohsiung Medical University Hospital, Taiwan.

Purpose: Cytomegalovirus (CMV) retinitis is one of the most common opportunistic infections in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). CMV retinitis in non-human immunodeficiency virus (HIV)-infected patients has been reported with variable presentations. Significant intraocular inflammation is common, and visual prognosis is poor if not properly managed. Read More

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September 2021

Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis.

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

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Ocular syphilis - a case series of four patients.

J Dtsch Dermatol Ges 2021 Jul 5;19(7):987-991. Epub 2021 May 5.

University Hospital and Clinic for Dermatology and Venereology, University Hospital Halle (Saale) of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Read More

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Ocular manifestations of people living with HIV in Tunisia.

South Afr J HIV Med 2021 19;22(1):1193. Epub 2021 Mar 19.

Department of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Background: Ocular involvement is a common complication of human immunodeficiency virus (HIV). Knowledge about this topic in Tunisia is limited.

Objective: To investigate ophthalmic manifestations in patients living with HIV in Tunisia. Read More

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Ocular Manifestations in Patients of HIV(Human Immunodeficiency Virus) Infection on Combined Anti-Retroviral Therapy (CART).

Ocul Immunol Inflamm 2021 Apr 1:1-9. Epub 2021 Apr 1.

Department of Medicine, Nodal Officer, ART Centre, Maulana Azad Medical College and Associated Lok Nayak Hospital, Delhi University, New Delhi, India.

: To determine the prevalence and spectrum of ocular manifestations in PLHIV (people living with Human Immunodeficiency Virus) on cART (combined Antiretroviral Therapy) and correlate them with WHO clinical staging, CD4 count, duration & type of cART.: Observational cross-sectional study. Ophthalmic evaluation of 350 PLHIV on cART (at least 6 months) was done. Read More

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Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis.

Trop Doct 2021 Jul 28;51(3):444-446. Epub 2021 Mar 28.

Department of Ophthalmology, 214250Army College of Medical Sciences & Base Hospital, Delhi, India.

Syphilis has a wide variety of ocular presentations such as anterior or posterior uveitis, chorioretinitis, retinal vasculitis, retinitis, perineuritis, papillitis, retrobulbar neuritis, optic atrophy and optic nerve gumma. Therefore, it is recommended to test every patient with ocular inflammation for syphilis. It is, however, a relatively rare cause of uveitis in HIV disease. Read More

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Bilateral preretinal hemorrhage associated with Kikuchi-Fujimoto disease.

Am J Ophthalmol Case Rep 2021 Jun 2;22:101041. Epub 2021 Mar 2.

Retina Institute of The Carolina and Macular Degeneration Center, Charlotte, NC, USA.

Purpose: To present a case of a patient with human immunodeficiency virus (HIV) disease and Kikuchi-Fujimoto disease (KFD) who presented with a unique pattern of retinopathy.

Observations: A 7-year-old Taiwanese girl with HIV disease who was recently diagnosed with KFD had a sudden onset of blurry vision in both eyes one month after her KFD systemic symptoms had relatively resolved. Ophthalmic examination showed decreased visual acuity in both eyes (OU). Read More

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Multimodal Imaging in AIDS-Related Ocular Cryptococcosis.

Case Rep Ophthalmol Med 2021 10;2021:8894075. Epub 2021 Feb 10.

Department of Ophthalmology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Purpose: To report multimodal imaging findings in two cases of AIDS-related cryptococcal chorioretinitis associated with uveitis and vasculitis.

Methods: Findings on clinical examination, color fundus photography, fluorescein and indocyanine green angiographies, and optical coherence tomography. . Read More

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February 2021

Sociodemographic predictors associated with the spectrum of non-opportunist neuroretinal disease of non-infectious etiology in patients with HIV/AIDS: a scoping review.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Feb 9. Epub 2021 Feb 9.

Fundación Oftalmológica de Santander - FOSCAL, Santander, Colombia; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: Non-infectious retinal disease, even in the HAART era, continues to be one of the most common diagnoses in patients with HIV, with prevalences of up to 27% of cases. This study aims to characterize the association between demographic variables and their role. as a risk factor for the development of non-opportunistic non-infectious retinal disease in patients with HIV/AIDS METHODS: An integrative review of the literature was carried out according to Arksey O'Malley's approach, based on the PICO methodology and following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) recommendations; An exhaustive search was carried out in databases of articles that were filtered using established criteria, with their extraction and analysis carried out qualitatively. Read More

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February 2021

Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis.

J Ophthalmic Vis Res 2021 Jan-Mar;16(1):103-112. Epub 2021 Jan 20.

Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Several studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19 patients. We searched Pubmed, Embase, Scopus, Web of Science, and medRxiv from December 1, 2019 to August 11, 2020. Read More

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January 2021

The value and implementation of routine ophthalmic examination in the era of HAART.

EClinicalMedicine 2021 Jan 22;31:100646. Epub 2020 Dec 22.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510000, China.

Background: The high prevalence of ocular manifestations (OMs) in patients with human immunodeficiency virus (HIV) infection and chronic diseases such as diabetes has become a global health issue. However, there is still a lack of an appropriate ophthalmic diagnostic procedure for the early detection of OMs in this population, leading to the risk of an irreversible visual impairment that substantially affects the quality of life of these patients.

Methods: The Guangzhou HIV Infection Study was a retrospective study that enrolled hospitalised HIV-infected patients in Guangzhou between January 2005 and December 2016, period corresponding to the highly active antiretroviral therapy (HAART) era in China. Read More

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January 2021

Ocular Syphilis Presenting as Acute Necrotizing Retinitis in a Human Immunodeficiency Virus-Positive Patient.

J Glob Infect Dis 2020 Jul-Sep;12(3):149-151. Epub 2020 Aug 29.

Department of Ophthalmology, AIIMS, Bhubaneswar, Odisha, India.

The incidence of ocular syphilis is increasing in the developing world even in the era of effective human immunodeficiency virus (HIV) treatment, as there is a potential increase of high-risk sexual behavior. Ocular involvement in the form of uveitis is seen in all stages of syphilis. Diagnosis begins with ophthalmologic examination, but requires serologic testing for confirmation. Read More

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AIDS Presenting in an Adolescent Male With Persistent Conjunctivitis and Eye Pain.

J Adolesc Health 2021 04 4;68(4):827-829. Epub 2020 Dec 4.

Children's National Health System, Department of Ophthalmology, Washington, District of Columbia.

An adolescent male with persistent conjunctivitis and an episcleral nodule presented with new-onset focal seizures and headaches. The patient was found to have cotton wool spots and papilledema on retinal examination. He was ultimately diagnosed with HIV retinopathy and AIDS. Read More

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Utility of Treponemal Testing from Aqueous Fluid in the Diagnosis of Ocular Syphilis in Patients with HIV/AIDS.

Ocul Immunol Inflamm 2022 Feb 5;30(2):444-450. Epub 2020 Oct 5.

L & T Microbiology Research Centre, Sankara Nethralaya, Chennai, India.

Purpose: Ocular syphilis is re-emerging globally especially in patients with human immunodeficiency virus (HIV). Atypical manifestations of ocular syphilis and/or other associated opportunistic infections often lead to a diagnostic dilemma. We evaluated the utility of aqueous humor (AH) hemagglutination assay (TPHA) titers in the diagnosis of ocular syphilis. Read More

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February 2022

Efavirenz-Associated Retinal Toxicity Presenting with Night Vision Defects in Patients with Human Immunodeficiency Virus.

Ocul Immunol Inflamm 2020 Oct 1;28(7):1076-1084. Epub 2020 Sep 1.

VHS Infectious Diseases Medical Center, Chennai Antiviral Research and Treatment (CART) Clinical Research Site, Voluntary Health Services , Chennai, India.

Ocular lesions in patients with human immunodeficiency virus (HIV) are commonly due to underlying opportunistic infections. With highly active antiretroviral therapy (HAART), infectious lesions have reduced and noninfectious ocular manifestations including drug-related side effects have been noted. While retinal toxicity has been noted with few other HAART drugs, there are not many on the same with Efavirenz usage. Read More

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October 2020

Study of ocular manifestations in tuberculosis and its association with HIV AIDS in a tertiary care hospital.

Indian J Tuberc 2020 Jul 18;67(3):320-326. Epub 2019 Oct 18.

Department of Ophthalmology, BJ Government Medical College, Pune, Maharashtra, India.

Objective: To assess and understand the prevalence and clinical presentation of ocular morbidity in patients suffering from tuberculosis and compare it with ocular involvement in patients coinfected with tuberculosis and HIV AIDS.

Materials And Methods: This was a non-comparative, observational, cross sectional study done on 580 patients, who were diagnosed cases of tuberculosis, pulmonary or extrapulmonary, on or off treatment, visiting the Ophthalmology OPD, Tuberculosis OPD and ART Centre of the institute in the period from March 2015 to March 2018, screened for ocular morbidity.

Results: Out of 580, 408 patients had only tuberculosis and 172 had tuberculosis with HIV AIDS. Read More

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