295 results match your criteria Ocular Manifestations of HIV


Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis.

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

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Ocular syphilis - a case series of four patients.

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

University Hospital and Clinic for Dermatology and Venereology, University Hospital Halle (Saale) of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Read More

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Ocular manifestations of people living with HIV in Tunisia.

South Afr J HIV Med 2021 19;22(1):1193. Epub 2021 Mar 19.

Department of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Background: Ocular involvement is a common complication of human immunodeficiency virus (HIV). Knowledge about this topic in Tunisia is limited.

Objective: To investigate ophthalmic manifestations in patients living with HIV in Tunisia. Read More

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Ocular Manifestations in Patients of HIV(Human Immunodeficiency Virus) Infection on Combined Anti-Retroviral Therapy (CART).

Ocul Immunol Inflamm 2021 Apr 1:1-9. Epub 2021 Apr 1.

Department of Medicine, Nodal Officer, ART Centre, Maulana Azad Medical College and Associated Lok Nayak Hospital, Delhi University, New Delhi, India.

: To determine the prevalence and spectrum of ocular manifestations in PLHIV (people living with Human Immunodeficiency Virus) on cART (combined Antiretroviral Therapy) and correlate them with WHO clinical staging, CD4 count, duration & type of cART.: Observational cross-sectional study. Ophthalmic evaluation of 350 PLHIV on cART (at least 6 months) was done. Read More

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Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis.

Trop Doct 2021 Mar 28:49475521998178. Epub 2021 Mar 28.

Department of Ophthalmology, 214250Army College of Medical Sciences & Base Hospital, Delhi, India.

Syphilis has a wide variety of ocular presentations such as anterior or posterior uveitis, chorioretinitis, retinal vasculitis, retinitis, perineuritis, papillitis, retrobulbar neuritis, optic atrophy and optic nerve gumma. Therefore, it is recommended to test every patient with ocular inflammation for syphilis. It is, however, a relatively rare cause of uveitis in HIV disease. Read More

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Bilateral preretinal hemorrhage associated with Kikuchi-Fujimoto disease.

Am J Ophthalmol Case Rep 2021 Jun 2;22:101041. Epub 2021 Mar 2.

Retina Institute of The Carolina and Macular Degeneration Center, Charlotte, NC, USA.

Purpose: To present a case of a patient with human immunodeficiency virus (HIV) disease and Kikuchi-Fujimoto disease (KFD) who presented with a unique pattern of retinopathy.

Observations: A 7-year-old Taiwanese girl with HIV disease who was recently diagnosed with KFD had a sudden onset of blurry vision in both eyes one month after her KFD systemic symptoms had relatively resolved. Ophthalmic examination showed decreased visual acuity in both eyes (OU). Read More

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Multimodal Imaging in AIDS-Related Ocular Cryptococcosis.

Case Rep Ophthalmol Med 2021 10;2021:8894075. Epub 2021 Feb 10.

Department of Ophthalmology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Purpose: To report multimodal imaging findings in two cases of AIDS-related cryptococcal chorioretinitis associated with uveitis and vasculitis.

Methods: Findings on clinical examination, color fundus photography, fluorescein and indocyanine green angiographies, and optical coherence tomography. . Read More

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February 2021

Sociodemographic predictors associated with the spectrum of non-opportunist neuroretinal disease of non-infectious etiology in patients with HIV/AIDS: a scoping review.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Feb 9. Epub 2021 Feb 9.

Fundación Oftalmológica de Santander - FOSCAL, Santander, Colombia; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: Non-infectious retinal disease, even in the HAART era, continues to be one of the most common diagnoses in patients with HIV, with prevalences of up to 27% of cases. This study aims to characterize the association between demographic variables and their role. as a risk factor for the development of non-opportunistic non-infectious retinal disease in patients with HIV/AIDS METHODS: An integrative review of the literature was carried out according to Arksey O'Malley's approach, based on the PICO methodology and following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) recommendations; An exhaustive search was carried out in databases of articles that were filtered using established criteria, with their extraction and analysis carried out qualitatively. Read More

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February 2021

Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis.

J Ophthalmic Vis Res 2021 Jan-Mar;16(1):103-112. Epub 2021 Jan 20.

Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Several studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19 patients. We searched Pubmed, Embase, Scopus, Web of Science, and medRxiv from December 1, 2019 to August 11, 2020. Read More

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January 2021

The value and implementation of routine ophthalmic examination in the era of HAART.

EClinicalMedicine 2021 Jan 22;31:100646. Epub 2020 Dec 22.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510000, China.

Background: The high prevalence of ocular manifestations (OMs) in patients with human immunodeficiency virus (HIV) infection and chronic diseases such as diabetes has become a global health issue. However, there is still a lack of an appropriate ophthalmic diagnostic procedure for the early detection of OMs in this population, leading to the risk of an irreversible visual impairment that substantially affects the quality of life of these patients.

Methods: The Guangzhou HIV Infection Study was a retrospective study that enrolled hospitalised HIV-infected patients in Guangzhou between January 2005 and December 2016, period corresponding to the highly active antiretroviral therapy (HAART) era in China. Read More

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January 2021

Ocular Syphilis Presenting as Acute Necrotizing Retinitis in a Human Immunodeficiency Virus-Positive Patient.

J Glob Infect Dis 2020 Jul-Sep;12(3):149-151. Epub 2020 Aug 29.

Department of Ophthalmology, AIIMS, Bhubaneswar, Odisha, India.

The incidence of ocular syphilis is increasing in the developing world even in the era of effective human immunodeficiency virus (HIV) treatment, as there is a potential increase of high-risk sexual behavior. Ocular involvement in the form of uveitis is seen in all stages of syphilis. Diagnosis begins with ophthalmologic examination, but requires serologic testing for confirmation. Read More

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AIDS Presenting in an Adolescent Male With Persistent Conjunctivitis and Eye Pain.

J Adolesc Health 2021 Apr 4;68(4):827-829. Epub 2020 Dec 4.

Children's National Health System, Department of Ophthalmology, Washington, District of Columbia.

An adolescent male with persistent conjunctivitis and an episcleral nodule presented with new-onset focal seizures and headaches. The patient was found to have cotton wool spots and papilledema on retinal examination. He was ultimately diagnosed with HIV retinopathy and AIDS. Read More

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Utility of Treponemal Testing from Aqueous Fluid in the Diagnosis of Ocular Syphilis in Patients with HIV/AIDS.

Ocul Immunol Inflamm 2020 Oct 5:1-7. Epub 2020 Oct 5.

L & T Microbiology Research Centre, Sankara Nethralaya, Chennai, India.

: Ocular syphilis is re-emerging globally especially in patients with human immunodeficiency virus (HIV). Atypical manifestations of ocular syphilis and/or other associated opportunistic infections often lead to a diagnostic dilemma. We evaluated the utility of aqueous humor (AH) hemagglutination assay (TPHA) titers in the diagnosis of ocular syphilis. Read More

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October 2020

Efavirenz-Associated Retinal Toxicity Presenting with Night Vision Defects in Patients with Human Immunodeficiency Virus.

Ocul Immunol Inflamm 2020 Oct 1;28(7):1076-1084. Epub 2020 Sep 1.

VHS Infectious Diseases Medical Center, Chennai Antiviral Research and Treatment (CART) Clinical Research Site, Voluntary Health Services , Chennai, India.

Ocular lesions in patients with human immunodeficiency virus (HIV) are commonly due to underlying opportunistic infections. With highly active antiretroviral therapy (HAART), infectious lesions have reduced and noninfectious ocular manifestations including drug-related side effects have been noted. While retinal toxicity has been noted with few other HAART drugs, there are not many on the same with Efavirenz usage. Read More

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October 2020

Study of ocular manifestations in tuberculosis and its association with HIV AIDS in a tertiary care hospital.

Indian J Tuberc 2020 Jul 18;67(3):320-326. Epub 2019 Oct 18.

Department of Ophthalmology, BJ Government Medical College, Pune, Maharashtra, India.

Objective: To assess and understand the prevalence and clinical presentation of ocular morbidity in patients suffering from tuberculosis and compare it with ocular involvement in patients coinfected with tuberculosis and HIV AIDS.

Materials And Methods: This was a non-comparative, observational, cross sectional study done on 580 patients, who were diagnosed cases of tuberculosis, pulmonary or extrapulmonary, on or off treatment, visiting the Ophthalmology OPD, Tuberculosis OPD and ART Centre of the institute in the period from March 2015 to March 2018, screened for ocular morbidity.

Results: Out of 580, 408 patients had only tuberculosis and 172 had tuberculosis with HIV AIDS. Read More

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Ocular syphilis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy.

Indian J Ophthalmol 2020 Sep;68(9):1887-1893

Department of Uveitis, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: Re-emergent ocular syphilis in patients with Human immunodeficiency virus (HIV) co-infection has both diagnostic and management difficulties because of the overlapping risk factors. The clinical manifestations described in non-HIV may not be the same in patients with HIV coinfection. Immune recovery uveitis (IRU) may also alter the course of the disease causing recurrences. Read More

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September 2020

Clinical manifestations and outcomes of ocular syphilis in Asian Indian population: Analysis of cases presenting to a tertiary referral center.

Indian J Ophthalmol 2020 Sep;68(9):1881-1886

Smt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.

Purpose: To describe disease manifestations and outcomes of ocular syphilis in Asian Indian population.

Methods: Retrospective analysis of patients diagnosed with ocular syphilis at a tertiary referral center in India. Demographics, history, extraocular and ocular manifestations, ocular and systemic investigations, treatment and visual acuity outcomes were noted. Read More

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September 2020

Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.

Indian J Ophthalmol 2020 Sep;68(9):1787-1798

Department of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School; Schepens Eye Research Institute, Boston, Massachusetts, USA; MCM Eye Unit, MyungSung Christian Medical Center (MCM) General Hospital and MyungSung Medical College, Addis Ababa, Ethiopia.

Intraocular inflammation in patients with human immunodeficiency virus (HIV) infection is commonly due to infectious uveitis. Ocular lesions due to opportunistic infections (OI) are the most common and have been described extensively in the pre highly active antiretroviral therapy (HAART) era. Many eye lesions were classified as acquired immunodeficiency syndrome (AIDS) defining illnesses. Read More

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September 2020

Ocular Tuberculosis in HIV-infected Individuals.

Ocul Immunol Inflamm 2020 Nov 18;28(8):1251-1258. Epub 2020 Aug 18.

Advanced Eye Center, Post Graduate Institute , Chandigarh, India.

To review the current literature and publications to assess the clinical features, recommended investigations and treatment for ocular tuberculosis in HIV infected patients. Literature review. The human immunodeficiency virus (HIV) epidemic affects as many as 37. Read More

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November 2020

Ocular manifestations in tuberculosis cases with HIV in Nepal.

Nepal J Ophthalmol 2019 Jul;11(22):130-137

Geta Eye Hospital.

Introduction: TB has seen resurgence associated with HIV. Tuberculosis can affect any ocular tissue. The association of HIV with TB is supposed to increase the incidence and plethora of ocular manifestations in tuberculosis. Read More

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Ocular tuberculosis epidemiology, clinic features and diagnosis: A brief review.

Tuberculosis (Edinb) 2020 09 21;124:101963. Epub 2020 Jul 21.

Team of Environmental Biotechnology, AGH University of Science and Technology, 300-059, Krakow, Poland; Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, 100000, Tashkent, Uzbekistan; Shanghai Jiao Tong University, 200240, Shanghai, China. Electronic address:

The spread of tuberculosis is directly related to the processes of globalization and migration. Tuberculosis has also been the main cause of fatality associated with antimicrobial resistance and also the main cause of death in people who have HIV infection. Additionally, tuberculosis smites the lungs in 80% of patients, and in the remaining 20% of patients the tuberculosis may smites other organs, such as the vision/eye. Read More

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September 2020

The role of human immunodeficiency virus in the pathogenesis of vernal keratoconjunctivitis-like disease in adults: A demographic and epidemiological study.

Indian J Ophthalmol 2020 08;68(8):1551-1554

Department of Ophthalmology, University of KwaZulu-Natal, Durban, South Africa.

Purpose: The purpose was to identify and describe patients with new-onset vernal keratoconjunctivitis-like (VKC-like) disease after puberty.

Methods: The study consisted of two parts: a prospective observational descriptive study of patients with new-onset VKC-like disease, and a case-control study to determine the relationship of a CD4 count with VKC-like disease in adults, in the setting of human immunodeficiency virus (HIV). Patients were recruited between January 2016 and November 2017 from a Provincial Eye hospital, one of two large referral hospitals in KwaZulu-Natal, South Africa. Read More

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Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals.

Ocul Immunol Inflamm 2020 Oct 13;28(7):1040-1048. Epub 2020 Jul 13.

Department of Ophthalmology and Otolaryngology, Faculdade de Medicina da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.

Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphilis in HIV-infected and -uninfected patients remains with some controversy due to unspecific clinical manifestations and limited diagnostic tests. Read More

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October 2020

Rare Ocular Involvement in a Newly Diagnosed AIDS Patient With Diffuse Kaposi's Sarcoma.

Cureus 2020 Jun 8;12(6):e8502. Epub 2020 Jun 8.

Internal Medicine, Methodist Health System, Dallas, USA.

Kaposi's sarcoma (KS) is a cancer that often affects individuals with human immunodeficiency virus, acquired immunodeficiency syndrome (AIDS), those who have received an organ transplant, or others who are immunocompromised. KS is a vascular tumor that most often presents in cutaneous sites, including the lower extremities, oral mucosa, and genitalia. Literature regarding KS with ocular involvement is scarce. Read More

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The neurologic phenotype of South African patients with HIV-associated neurocognitive impairment.

Neurol Clin Pract 2020 Feb;10(1):15-22

Division of Clinical Pharmacology (SGA, EHD), Faculty of Medicine and Health Sciences, University of Stellenbosch; Biostatistics Unit (MM), Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; Institute of Translational Medicine (SK), University of Liverpool, and Royal Liverpool University Hospital, United Kingdom; Division of Clinical Pharmacology (LW), Department of Medicine, University of Cape Town, South Africa; Department of Neurology (NS), Johns Hopkins University School of Medicine, Baltimore, MD; and Division of Neuropsychiatry (JAJ), Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, South Africa.

Background: The neurologic manifestations of HIV include a spectrum of HIV-associated neurocognitive disorders, as well as a cluster of neurologic symptoms and signs. The neurologic manifestations have been modified but not eradicated by antiretroviral therapy (ART). We describe the neurologic phenotype in South African patients with predominant HIV-1 subtype C infection on ART and its association with neurocognitive impairment and efavirenz and 8-hydroxy-efavirenz concentrations. Read More

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February 2020

Disease of the Year 2019: Ocular Toxoplasmosis in HIV-infected Patients.

Ocul Immunol Inflamm 2020 Oct 12;28(7):1031-1039. Epub 2020 Mar 12.

Gepamol. Centro de Investigaciones Biomédicas, Universidad del Quindío , Armenia, Q, Colombia.

Ocular toxoplasmosis (OT) may be an initial manifestation of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-infected patients. OT has different clinical manifestations and can mimic other intraocular infections. Clinical findings may show single or multifocal retinochoroidal lesions or panuveitis. Read More

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October 2020

Evaluation of the level of awareness of congenital toxoplasmosis and associated practices among pregnant women and health workers in Tanzania's Temeke district in Dar es Salaam.

Afr Health Sci 2019 Dec;19(4):3027-3037

University of Zambia School of Veterinary Medicine, clinical studies.

Background: Toxoplasmosis caused by the obligate intracellular coccidian protozoan T () infects all warm-blooded animals including humans. This parasite may develop in both immune-compromised and immunocompetent hosts but usually the disease manifestations strongly differ according to immune status. Immunocompromised hosts develop more severe disease than immunocompetent hosts. Read More

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December 2019

Ocular syphilis in an immunocompetent host.

IDCases 2020 26;19:e00684. Epub 2019 Dec 26.

University Of Illinois College of Medicine, Department of Medicine, Peoria, IL, USA.

Syphilis is an old disease that experienced a resurgence with the emergence of HIV/AIDS. Syphilis is a reportable infection that is monitored by the Centers for disease Control (CDC) in the U.S. Read More

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December 2019

Resurgence of ocular syphilis in British Columbia between 2013-2016: a retrospective chart review.

Can J Ophthalmol 2020 04 27;55(2):179-184. Epub 2019 Dec 27.

British Columbia Centre for Disease Control, Vancouver, B.C.. Electronic address:

Objective: To characterize the trends and explore the demographics, ophthalmic manifestations, and outcomes of ocular syphilis cases in British Columbia.

Design: Retrospective chart review.

Participants: Ocular syphilis cases reported to the British Columbia Centre for Disease Control (BCCDC) between January 2013 and December 2016. Read More

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Auditory, video head impulse test and vestibular evoked myogenic potentials findings in adults with human immunodeficiency virus.

Auris Nasus Larynx 2020 Jun 18;47(3):367-376. Epub 2019 Dec 18.

Department of Internal Medicine, Steve Biko Academic Hospital, Private bag X20, Hatfield 0028, Pretoria, South Africa.

Objectives: Even though there is an association between hearing loss and human immunodeficiency virus (HIV), particularly in low- and middle-income countries, further research is needed to investigate the nature of such hearing loss. Likewise, despite documented vestibular alterations in people with HIV, the true occurrence, presentation, and nature of these manifestations are yet to be established. Advances in technology for vestibular testing has allowed for objective site-of-lesion tests such as the video head impulse test (vHIT), cervical vestibular evoked myogenic potentials (cVEMPs) and ocular vestibular evoked myogenic potential (oVEMPs). Read More

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