270 results match your criteria Ocular Manifestations of HIV


The neurologic phenotype of South African patients with HIV-associated neurocognitive impairment.

Neurol Clin Pract 2020 Feb;10(1):15-22

Division of Clinical Pharmacology (SGA, EHD), Faculty of Medicine and Health Sciences, University of Stellenbosch; Biostatistics Unit (MM), Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; Institute of Translational Medicine (SK), University of Liverpool, and Royal Liverpool University Hospital, United Kingdom; Division of Clinical Pharmacology (LW), Department of Medicine, University of Cape Town, South Africa; Department of Neurology (NS), Johns Hopkins University School of Medicine, Baltimore, MD; and Division of Neuropsychiatry (JAJ), Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, South Africa.

Background: The neurologic manifestations of HIV include a spectrum of HIV-associated neurocognitive disorders, as well as a cluster of neurologic symptoms and signs. The neurologic manifestations have been modified but not eradicated by antiretroviral therapy (ART). We describe the neurologic phenotype in South African patients with predominant HIV-1 subtype C infection on ART and its association with neurocognitive impairment and efavirenz and 8-hydroxy-efavirenz concentrations. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057065PMC
February 2020

Disease of the Year 2019: Ocular Toxoplasmosis in HIV-infected Patients.

Ocul Immunol Inflamm 2020 Mar 12:1-9. Epub 2020 Mar 12.

Gepamol. Centro de Investigaciones Biomédicas, Universidad del Quindío, Armenia, Q, Colombia.

Ocular toxoplasmosis (OT) may be an initial manifestation of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-infected patients. OT has different clinical manifestations and can mimic other intraocular infections. Clinical findings may show single or multifocal retinochoroidal lesions or panuveitis. Read More

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http://dx.doi.org/10.1080/09273948.2020.1735450DOI Listing

Evaluation of the level of awareness of congenital toxoplasmosis and associated practices among pregnant women and health workers in Tanzania's Temeke district in Dar es Salaam.

Afr Health Sci 2019 Dec;19(4):3027-3037

University of Zambia School of Veterinary Medicine, clinical studies.

Background: Toxoplasmosis caused by the obligate intracellular coccidian protozoan T () infects all warm-blooded animals including humans. This parasite may develop in both immune-compromised and immunocompetent hosts but usually the disease manifestations strongly differ according to immune status. Immunocompromised hosts develop more severe disease than immunocompetent hosts. Read More

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http://dx.doi.org/10.4314/ahs.v19i4.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040330PMC
December 2019

Ocular syphilis in an immunocompetent host.

IDCases 2020 26;19:e00684. Epub 2019 Dec 26.

University Of Illinois College of Medicine, Department of Medicine, Peoria, IL, USA.

Syphilis is an old disease that experienced a resurgence with the emergence of HIV/AIDS. Syphilis is a reportable infection that is monitored by the Centers for disease Control (CDC) in the U.S. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030984PMC
December 2019

Resurgence of ocular syphilis in British Columbia between 2013-2016: a retrospective chart review.

Can J Ophthalmol 2020 Apr 27;55(2):179-184. Epub 2019 Dec 27.

British Columbia Centre for Disease Control, Vancouver, B.C.. Electronic address:

Objective: To characterize the trends and explore the demographics, ophthalmic manifestations, and outcomes of ocular syphilis cases in British Columbia.

Design: Retrospective chart review.

Participants: Ocular syphilis cases reported to the British Columbia Centre for Disease Control (BCCDC) between January 2013 and December 2016. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.11.002DOI Listing
April 2020
1.299 Impact Factor

Auditory, video head impulse test and vestibular evoked myogenic potentials findings in adults with human immunodeficiency virus.

Auris Nasus Larynx 2019 Dec 17. Epub 2019 Dec 17.

Department of Internal Medicine, Steve Biko Academic Hospital, Private bag X20, Hatfield 0028, Pretoria, South Africa.

Objectives: Even though there is an association between hearing loss and human immunodeficiency virus (HIV), particularly in low- and middle-income countries, further research is needed to investigate the nature of such hearing loss. Likewise, despite documented vestibular alterations in people with HIV, the true occurrence, presentation, and nature of these manifestations are yet to be established. Advances in technology for vestibular testing has allowed for objective site-of-lesion tests such as the video head impulse test (vHIT), cervical vestibular evoked myogenic potentials (cVEMPs) and ocular vestibular evoked myogenic potential (oVEMPs). Read More

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http://dx.doi.org/10.1016/j.anl.2019.11.006DOI Listing
December 2019

[Diagnostics of early signs of ocular pathology in patients with HIV/tuberculosis co-infection].

Vestn Oftalmol 2019 ;135(5):61-69

Ural Research Institute of Phthisiopulmonology of the National Medical Research Center for Phthisiopulmonology and Infectious Diseases, 50, 22.

Introduction: The current epidemic situation in Russia is characterized by increasing rate of co-infection (HIV/tuberculosis). Damage to the organ of vision is more common among patients with this pathology, presenting significant difficulties in diagnosis of the ophthalmic manifestations. High-tech imaging method - optical coherence tomography (OCT) allows exploration of the eye tissues with high accuracy and depth, as well as evaluation of the structure of the choroid and microcirculation parameters of the anterior and posterior eye segments. Read More

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http://dx.doi.org/10.17116/oftalma201913505161DOI Listing
November 2019

Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis.

Ocul Immunol Inflamm 2019 Oct 24:1-7. Epub 2019 Oct 24.

Ophthalmology, CHU Saint-Pierre and Brugmann, Université Libre de Bruxelles , Brussels , Belgium.

: To evaluate neurosyphilis cerebrospinal fluid (CSF) findings and initial ophthalmic manifestations in patients with syphilitic uveitis. : We retrospectively reviewed the records of CSF analysis of 14 patients with syphilitic uveitis with treponemal analysis - chemiluminescent immunoassay and TPHA- and non-treponemal analysis - Rapid Plasma Reagin test - RPR. : 86% were males and 43% HIV+. Read More

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http://dx.doi.org/10.1080/09273948.2019.1672193DOI Listing
October 2019
1 Read

Endogenous endophthalmitis and other ocular manifestations of injection drug use.

Curr Opin Ophthalmol 2019 Nov;30(6):506-512

Section of Ophthalmology, Department of Surgery, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

Purpose Of Review: The United States has experienced a dramatic rise in opioid and injection drug use over the past 2 decades. A public health emergency was declared in 2017 and subsequently, there have been several new reports on the rise of endogenous endophthalmitis specifically associated with injection drug use. The purpose of this review is to provide a current perspective of the ocular harms posed by injection drug use. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000606DOI Listing
November 2019
1 Read

Study of prevalence of ocular manifestations in HIV positive patients.

Nepal J Ophthalmol 2019 Jan;11(21):11-18

Department of Ophthalmology, SHKM, GMC Nalhar, Nuh.

Introduction: HIV/AIDS is a disorder which affects multiple systems in our body but ophthalmic manifestations do occur in 70-80% of patients sometime during their lifetime. Eye is affected either directly by HIV virus or indirectly through various opportunistic infections. HIV related ophthalmic manifestations are wide and can affect any part of eye from a dnexal disorders to posterior segment diseases including the optic nerve and the optic tract. Read More

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http://dx.doi.org/10.3126/nepjoph.v11i1.25411DOI Listing
January 2019
3 Reads

Intravitreal sustained-release dexamethasone implant for the treatment of persistent cystoid macular edema in ocular syphilis.

Indian J Ophthalmol 2019 09;67(9):1487-1490

Department of Uvea, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India.

With a resurgence of syphilis with human immunodeficiency virus (HIV) infection in last few years, various ocular manifestations of syphilis have been described in literature. This case report described an HIV-positive patient on anti-retroviral therapy who was diagnosed and treated for posterior uveitis secondary to ocular syphilis in the recent past presented to our clinic with cystoid macular edema (CME). CME, which did not respond to periocular corticosteroid, resolved with intravitreal sustained release dexamethasone implant. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1795_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727693PMC
September 2019
2 Reads

Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient.

Open Access Maced J Med Sci 2019 Jun 25;7(12):1987-1990. Epub 2019 Jun 25.

Department of Ophthalmology, Faculty of Medicine, Udayana University, Bali, Indonesia.

Background: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients.

Case Presentation: A 53-years old, bisexual, male patient whose initial presentation was a blurry vision on the left eye. Read More

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http://dx.doi.org/10.3889/oamjms.2019.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684424PMC
June 2019
3 Reads

papillitis without vitritis. A case report in an immunocompetent Congolese patient.

Germs 2019 Jun 3;9(2):95-101. Epub 2019 Jun 3.

MD, PhD, Department of Ophthalmology, University Hospital of Kinshasa, Kinshasa University, P.O. Box 123, Kinshasa XI, DR Congo.

Introduction: Unilateral papillitis and neuroretinitis are uncommon manifestations of ocular infection and pose particularly challenging diagnosis problems. Due to the limited accessibility of healthcare and poor socioeconomic status of a significant proportion of the population in Democratic Republic of the Congo, knowledge of seroprevalence rates for toxoplasmosis remains key to the health system. When papillitis or neuroretinitis is suspected, vitreous inflammatory reaction is usually present at various degrees on the initial examination as a diagnosis clue. Read More

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http://dx.doi.org/10.18683/germs.2019.1163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591526PMC
June 2019
4 Reads

Management of Systemic Steroid in HIV Patient with Toxoplasma Papillitis.

Open Access Maced J Med Sci 2019 Jun 14;7(11):1821-1824. Epub 2019 Jun 14.

Internal Medicine Department, Faculty of Medicine, Udayana Unoversity, Sanglah Hospital, Denpasar, Bali, Indonesia.

Background: Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. Ocular manifestations are seen in both congenital and acquired toxoplasmosis. These can include focal inflammation within or around the optic nerve head (papillitis). Read More

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http://dx.doi.org/10.3889/oamjms.2019.488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614278PMC
June 2019
3 Reads

Coexistence of Papillitis and Posterior Placoid Chorioretinopathy as the Presenting Symptoms of Syphilis-Human Immunodeficiency Virus Coinfection.

Neuroophthalmology 2019 Jun 20;43(3):196-200. Epub 2018 Jul 20.

Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey.

A 27-year-old male was presented with a decrease in vision in the left eye. Best-corrected visual acuity was 10/10 in the right eye and counting fingers at 2 m in the left eye. On fundus examination, the left optic disc was oedematous and there was a wide yellowish, well-defined placoid lesion between the temporal vascular arcades with mild vitreous inflammation. Read More

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http://dx.doi.org/10.1080/01658107.2018.1493515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619981PMC
June 2019
6 Reads

Ocular Manifestations in Patients with HIV infection.

Cesk Slov Oftalmol 2019 ;74(6):234-239

Background And Aims: To evaluate the characteristics and incidence of ophthalmic manifestations in patients with HIV (Human Immunodeficiency Virus) infection.

Materials And Methods: A retrospective evaluation of medical records of 147 patients with HIV infection (22 female, 125 male), the average age of 41 (range 22-79 years) examined by an ophthalmologist at the Clinic of Ophthalmology at the University Hospital Ostrava in years 1987 - 2015.

Results: Ophthalmic manifestations of HIV were observed in 16 patients (11. Read More

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http://dx.doi.org/10.31348/2018/6/3DOI Listing
August 2019
4 Reads

Clinical Profile and Visual Outcomes of Ocular Syphilis: A Five-year Review in Hospital Universiti Sains, Malaysia.

Cureus 2019 Feb 5;11(2):e4015. Epub 2019 Feb 5.

Ophthalmology, Universiti Sains Malaysia, Kota Bharu, MYS.

Introduction Ocular syphilis is a sight-threatening condition. It can occur at any stage of syphilis infection, which present either with acute inflammation during the primary, secondary, and early latent stages or with chronic inflammation during tertiary infection, affecting virtually every ocular structure. This study was to report on the clinical presentation of ocular syphilis that presented to eye clinic Hospital Universiti Sains Malaysia. Read More

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http://dx.doi.org/10.7759/cureus.4015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453624PMC
February 2019
15 Reads

[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0854-3421
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http://dx.doi.org/10.1055/a-0854-3421DOI Listing
April 2019
39 Reads

[The ocular manifestations of human immunodeficiency virus and syphilis coinfection].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.008DOI Listing
April 2019
34 Reads

Presentation of Ocular Syphilis in a HIV-Positive Patient with False-Negative Serologic Screening.

Case Rep Infect Dis 2019 3;2019:8191724. Epub 2019 Feb 3.

Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ, USA.

Purpose: The ocular sequelae of syphilis are devastating and may cause blindness. The ambiguous nature of its ocular manifestations makes syphilis difficult to detect. Though uncommon, the rise of syphilis in the United States requires a renewed understanding of its ophthalmic presentation to prevent devastating outcomes. Read More

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http://dx.doi.org/10.1155/2019/8191724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377954PMC
February 2019
9 Reads

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis.

Acta Ophthalmol 2019 Jun 17;97(4):e641-e647. Epub 2018 Oct 17.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Ocular manifestations of syphilis have been reported in 2-10% of systemic infection. The purpose of this study was to report the incidence of ocular syphilis and various ocular manifestations, particularly optic nerve involvement, in newly diagnosed cases.

Methods: This was a retrospective study. Read More

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http://dx.doi.org/10.1111/aos.13963DOI Listing
June 2019
13 Reads

Ocular manifestations of cytomegalovirus in immunocompetent hosts.

Curr Opin Ophthalmol 2018 Nov;29(6):535-542

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, USA.

Purpose Of Review: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts.

Recent Findings: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium. Read More

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http://Insights.ovid.com/crossref?an=00055735-900000000-9924
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http://dx.doi.org/10.1097/ICU.0000000000000521DOI Listing
November 2018
12 Reads

Ocular Manifestations of Human Immunodeficiency Virus Infection at a Tertiary Referral Center in Taiwan.

Ocul Immunol Inflamm 2019 6;27(7):1071-1076. Epub 2018 Sep 6.

Department of Ophthalmology, Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.

: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) : A retrospective cohort study in Taiwan was performed between January 2006 and July 2016. Ocular examination and systemic information were recorded from the HIV-infected patients. : 1242 patients with HIV/AIDS were identified. Read More

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http://dx.doi.org/10.1080/09273948.2018.1499939DOI Listing
April 2020
15 Reads

Tuberculosis treatment failure in AIDS: vengeance with renal and ocular manifestations.

BMJ Case Rep 2018 Aug 31;2018. Epub 2018 Aug 31.

Montefiore Medical Center, Bronx, New York, USA.

Tuberculosis treatment failure is not uncommon in patients with AIDS. Treatment failure is defined as a positive sputum smear or culture at month 5 or later in the course of the treatment. The clinical presentations in these patients show remarkable heterogeneity. Read More

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http://dx.doi.org/10.1136/bcr-2018-225955DOI Listing
August 2018
24 Reads

Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.

Sci Rep 2018 08 13;8(1):12071. Epub 2018 Aug 13.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

Recent reports from different world regions suggest ocular syphilis is re-emerging, in parallel with an increasing incidence of the systemic infection globally. We conducted a large observational study of 127 persons consecutively treated for ocular syphilis at public medical centers in Brazil over a 2.5-year period ending July 2015. Read More

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http://dx.doi.org/10.1038/s41598-018-30559-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089995PMC
August 2018
25 Reads

Ocular manifestations in patients attending antiretroviral therapy centre at a tertiary care hospital in Himachal Pradesh, India.

Indian J Med Res 2018 05;147(5):496-500

Department of Medicine, Dr. Rajendra Prasad Government Medical College, Kangra, India.

Background & Objectives: Ocular manifestations in HIV/AIDS patients range from adnexal disorders to the posterior segment disease. This study was aimed to evaluate the ocular manifestations, including vision-threatening manifestations in HIV-positive patients attending an antiretroviral therapy centre (ART) of a tertiary care hospital in north India and its association with the CD4+ cell count.

Methods: This cross-sectional study was conducted in the department of Ophthalmology in collaboration with the ART centre. Read More

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http://www.ijmr.org.in/text.asp?2018/147/5/496/238227
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http://dx.doi.org/10.4103/ijmr.IJMR_1037_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094518PMC
May 2018
22 Reads

Kaposi's sarcoma of the conjunctiva and the eyelid leads to the diagnosis of human immunodeficiency virus infection - a case report.

BMC Cancer 2018 Jul 3;18(1):708. Epub 2018 Jul 3.

Department of Ophthalmology, Centro Hospitalar Vila Nova de Gaia/Espinho, Avenida Cidade de Montgeron, 212 -, 4490-402, Póvoa de Varzim, Portugal.

Background: The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection.

Case Presentation: A 32-year old white man presented to our department with a 1 month history of eye redness. Read More

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http://dx.doi.org/10.1186/s12885-018-4611-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029361PMC
July 2018
17 Reads

Herpetic ocular manifestations in a patient with GATA2 deficiency.

Saudi J Ophthalmol 2018 Apr-Jun;32(2):164-166. Epub 2017 Nov 13.

12 de Octubre University Hospital, Ophthalmology Department, Complutense University, Madrid, Spain.

Specific genetic deficiencies are a rare cause that should be included in the diagnostic algorithm of disseminated herpetic lesions. The aim of this article is to describe the ocular herpetic manifestations in a rare genetic disorder called GATA2 deficiency. We present the clinical case of a 26-year-old male with dendritic ulcers in his cornea, marrow aplasia and idiopathic chronic lymphedema. Read More

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http://dx.doi.org/10.1016/j.sjopt.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010607PMC
November 2017
31 Reads

Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient.

Case Rep Infect Dis 2018 18;2018:2840241. Epub 2018 Feb 18.

University of Nebraska Medical Center, S. 42nd and Emile St., Omaha, NE, USA.

. is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Read More

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http://dx.doi.org/10.1155/2018/2840241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835303PMC
February 2018
20 Reads

Ocular surface squamous neoplasia in HIV-infected patients: current perspectives.

HIV AIDS (Auckl) 2018 14;10:33-45. Epub 2018 Mar 14.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.

Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure. Read More

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http://dx.doi.org/10.2147/HIV.S120517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857154PMC
March 2018
6 Reads

Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study.

PLoS One 2018 21;13(2):e0193161. Epub 2018 Feb 21.

Ophthalmology department, Chiang Mai University Hospital, Chiang Mai, Thailand.

Human immunodeficiency virus (HIV) causes impairment to the human immune system which leads to immunocompromised conditions, including ocular complications. Several important HIV-associated disorders may involve the anterior segment, ocular surface, and adnexae organ such as dry eye, blepharitis which reduce quality of life of patients. In present, potent antiretroviral therapies HAART (highly active antiretroviral therapy) has improved the length and quality of life which may lead to an increased prevalence of anterior segment ocular disorders. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193161PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821368PMC
May 2018
28 Reads

Secondary pulmonary syphilis: Case report and review of literature.

Ann Dermatol Venereol 2018 Apr 17;145(4):278-287. Epub 2018 Feb 17.

Service de dermatologie, hôpital Emile-Muller, GHR Mulhouse-Sud Alsace, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.

Introduction: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review.

Patients And Methods: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. Read More

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http://dx.doi.org/10.1016/j.annder.2017.11.015DOI Listing
April 2018
19 Reads

Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.

Medicine (Baltimore) 2017 Oct;96(43):e8376

aDepartment of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University College of Medicine bDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. Read More

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http://dx.doi.org/10.1097/MD.0000000000008376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671864PMC
October 2017
52 Reads

[Neurosyphilis: A retrospective study of 13 cases at Strasbourg University Hospital].

J Fr Ophtalmol 2017 Oct 1;40(8):654-660. Epub 2017 Sep 1.

Laboratoire de bactériologie, CHU de Strasbourg, 67000 Strasbourg, France.

Objective: After a decade of constant decline, the number of syphilis cases has been steadily increasing since the 2000s, particularly in HIV infected patients. Neurosyphilis is a rare manifestation of this sexually transmitted disease for which we performed a retrospective study and analyzed clinical manifestations.

Patients And Methods: We reviewed retrospectively all the neurosyphilis cases admitted to Strasbourg University Hospital between 2004 and 2014. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.03.007DOI Listing
October 2017
22 Reads

Neurosyphilis in Africa: A systematic review.

PLoS Negl Trop Dis 2017 Aug 31;11(8):e0005880. Epub 2017 Aug 31.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Introduction: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597251PMC
August 2017
74 Reads

Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient.

Indian J Ophthalmol 2017 May;65(5):413-416

Department of Uvea and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Vogt-Koyanagi-Harada (VKH), a multisystem autoimmune bilateral panuveitis with systemic manifestations, is uncommon in immunocompromised patients such as human immunodeficiency virus (HIV)/acquired immunodeficiency disease syndrome (AIDS). We report a rare presentation of VKH in a 45-year-old HIV-positive female on highly active antiretroviral therapy (HAART) who presented with a history of recurrent panuveitis. A diagnosis of probable VKH was made based on ocular and systemic signs and symptoms. Read More

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http://dx.doi.org/10.4103/ijo.IJO_544_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565895PMC
May 2017
54 Reads

Factors Contributing to Long-Term Severe Visual Impairment in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

J Ophthalmol 2017 26;2017:2087578. Epub 2017 Mar 26.

Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

. To study the correlation between demographics and clinical variables and long-term severe visual impairment in patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). . Read More

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http://dx.doi.org/10.1155/2017/2087578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385247PMC
March 2017
15 Reads

Eye changes among HIV positive patients on antiretroviral therapy in Nepal.

Nepal J Ophthalmol 2016 01;8(15):62-70

Objective: To find out eye findings among HIV positive patients in the era of antiretroviral therapy. Method This Hospital based cross sectional descriptive study was carried at B. P. Read More

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http://dx.doi.org/10.3126/nepjoph.v8i1.16158DOI Listing
January 2016
8 Reads

Uveitis as an initial manifestation of acquired immunodeficiency syndrome.

Int J STD AIDS 2017 10 15;28(12):1224-1228. Epub 2017 Feb 15.

1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a multisystem disease that can involve the human eyes. Using ophthalmic examination records from January 2006 to November 2015, we retrospectively reviewed all patients who were diagnosed with HIV/AIDS in our hospital. The study was performed at a tertiary referral center in southern Taiwan. Read More

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http://dx.doi.org/10.1177/0956462417694569DOI Listing
October 2017
46 Reads

Testing for Zika virus infection in pregnancy: key concepts to deal with an emerging epidemic.

Am J Obstet Gynecol 2017 03 23;216(3):209-225. Epub 2017 Jan 23.

Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, TX; National School for Tropical Medicine, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Texas Children's Hospital, Houston, TX. Electronic address:

Zika virus is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Following epidemics in Micronesia and French Polynesia during the past decade, more recent Zika virus infection outbreaks were first reported in South America as early as May 2013 and spread to now 50 countries throughout the Americas. Although no other flavivirus has previously been known to cause major fetal malformations following perinatal infection, reports of a causal link between Zika virus and microcephaly, brain and ocular malformations, and fetal loss emerged from hard-hit regions of Brazil by October 2015. Read More

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http://dx.doi.org/10.1016/j.ajog.2017.01.020DOI Listing
March 2017
77 Reads

Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015.

MMWR Morb Mortal Wkly Rep 2016 Nov 4;65(43):1185-1188. Epub 2016 Nov 4.

Ocular syphilis, a manifestation of Treponema pallidum infection, can cause a variety of ocular signs and symptoms, including eye redness, blurry vision, and vision loss. Although syphilis is nationally notifiable, ocular manifestations are not reportable to CDC. Syphilis rates have increased in the United States since 2000. Read More

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http://dx.doi.org/10.15585/mmwr.mm6543a2DOI Listing
November 2016
44 Reads

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes.

Korean J Ophthalmol 2016 Oct 29;30(5):360-368. Epub 2016 Sep 29.

Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.

Purpose: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection.

Methods: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Read More

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http://dx.doi.org/10.3341/kjo.2016.30.5.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057012PMC
October 2016
20 Reads

Necrotizing retinitis due to syphilis in a patient with AIDS.

IDCases 2016 21;6:17-9. Epub 2016 Aug 21.

Indiana University Department of Medicine, United States.

The ocular manifestations of syphilis are varied. Ocular syphilis can occur during any stage of infection and involve virtually any part of the eye. In immunocompetent individuals, the most common etiologies include syphilitic uveitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021766PMC
September 2016
21 Reads

Kaposi Sarcoma of the eyelid as an initial manifestation of AIDS.

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

Department of Dermatovenereology of Centro Hospitalar de Lisboa Norte, Lisboa, Portugal.

Kaposi sarcoma (KS) is a multifocal systemic disease that originates in the vascular endothelium related to Human Herpes Virus 8 (HHV-8). In the early 1980s the first series of cases of disseminated Kaposi Sarcoma in HIV infected patients were reported. However, with the advent of highly active antiretroviral therapy (HAART) since 1997, these cases are less frequently observed by clinicians. Read More

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July 2016
54 Reads

Don't Forget What You Can't See: A Case of Ocular Syphilis.

West J Emerg Med 2016 Jul 21;17(4):473-6. Epub 2016 Jun 21.

University of Texas, Health Science Center, San Antonio, Department of Emergency Medicine, San Antonio, Texas.

This case describes an emergency department (ED) presentation of ocular syphilis in a human immunodeficiency virus (HIV) infected patient. This is an unusual presentation of syphilis and one that emergency physicians should be aware of. The prevalence of syphilis has reached epidemic proportions since 2001 with occurrences primarily among men who have sex with men (MSM). Read More

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http://dx.doi.org/10.5811/westjem.2016.5.28933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944808PMC
July 2016
37 Reads

Molecular Typing of Treponema pallidum in Ocular Syphilis.

Sex Transm Dis 2016 08;43(8):524-7

From the *Centers for Disease Control and Prevention, Atlanta, GA; †Department of Neurology, and ‡Department of Medicine (Infectious Diseases), University of Washington School of Medicine, Seattle, WA.

Background: Syphilis can have many clinical manifestations, including eye involvement, or "ocular syphilis." In 2015, an increase in reported cases of ocular syphilis and potential case clusters raised concern for an oculotropic strain of Treponema pallidum, the infectious agent of syphilis. Molecular typing was used to examine strains found in cases of ocular syphilis in the United States. Read More

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http://pdfs.journals.lww.com/stdjournal/2016/08000/Molecular
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http://dx.doi.org/10.1097/OLQ.0000000000000478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253705PMC
August 2016
54 Reads

Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients.

BMC Infect Dis 2016 06 6;16:245. Epub 2016 Jun 6.

Department of Dermatology, Shanghai Xuhui Central Hospital, Shanghai, People's Republic of China.

Background: Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients.

Methods: The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1186/s12879-016-1586-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895961PMC
June 2016
19 Reads

Analysis and Outcomes of Cataract Surgery in Patients with Acquired Immunodeficiency Syndrome.

Ocul Immunol Inflamm 2017 Aug 15;25(4):535-539. Epub 2016 Apr 15.

a National Healthcare Group Eye Institute Tan Tock Seng Hospital , Singapore.

Purpose: To investigate the surgical outcomes, complications and postoperative progression in HIV patients undergoing cataract surgery in a teaching hospital.

Methods: A retrospective cohort study of patients with HIV/AIDS who had cataract surgery from January 2000 until December 2011 at a tertiary referral multidisciplinary hospital in Singapore.

Results: We identified 44 eyes from 29 patients. Read More

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http://dx.doi.org/10.3109/09273948.2016.1158281DOI Listing
August 2017
13 Reads