192,102 results match your criteria Ocular Manifestations of Albinism


Interferon-α-induced retinopathy in chronic hepatitis C treatment: summary, considerations, and recommendations.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-α with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-α is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. Read More

View Article
December 2018

A Case of Acute Granulomatous Conjunctivitis Caused by Cat-transmitted Sporothrix schenckii.

Cureus 2018 Oct 8;10(10):e3428. Epub 2018 Oct 8.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kota Bharu, MYS.

In human, sporotrichosis infection commonly manifests as skin lesions through direct inoculation. It is rarely associated with ocular manifestation via a zoonotic transmission. We describe a young lady who presented with acute left eye granulomatous conjunctivitis who had a history of exposure to her sick cat diagnosed with sporotrichosis infection. Read More

View Article
October 2018

Retinal burns from laser pointers: a risk in children with behavioural problems.

Eye (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Bolton Hospitals NHS Foundation Trust, Bolton, UK.

Objective: To explore self-inflicted retinal burns from laser pointers in children.

Methods: Literature review of laser pointer retinal injuries in childhood and online survey of UK Consultant Ophthalmologists. A cohort of local children with self-inflicted injury is described. Read More

View Article
December 2018

Air pollutant particulate matter 2.5 induces dry eye syndrome in mice.

Sci Rep 2018 Dec 13;8(1):17828. Epub 2018 Dec 13.

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.

In this study, we explored the effects of particulate matter 2.5 (PM) eye drops on the ocular surface structure and tear function in mice and established a novel animal model for dry eye research. We found that, following treatment with PM, the tear volume and, the tear film break-up time showed statistical differences at each time point (P < 0. Read More

View Article
December 2018

Reduced vision-related quality of life in people living with dystonia.

Disabil Rehabil 2018 Dec 13:1-5. Epub 2018 Dec 13.

e School of Psychology, University of South Australia , Adelaide , Australia.

Purpose: Dystonia is a neurological movement disorder with negative impact on function and quality of life. It is currently unclear whether vision-related quality of life is affected. The aim of this study was to determine whether vision-related quality of life is reduced by dystonia. Read More

View Article
December 2018

Neurological and Inflammatory Manifestations in Sjögren's Syndrome: The Role of the Kynurenine Metabolic Pathway.

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Ribeirao Preto Medical School, Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049-900 Brazil.

For decades, neurological, psychological, and cognitive alterations, as well as other glandular manifestations (EGM), have been described and are being considered to be part of Sjögren's syndrome (SS). Dry eye and dry mouth are major findings in SS. The lacrimal glands (LG), ocular surface (OS), and salivary glands (SG) are linked to the central nervous system (CNS) at the brainstem and hippocampus. Read More

View Article
December 2018

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility.

Medicine (Baltimore) 2018 Dec;97(49):e13547

Department of Ophthalmology, the First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China.

Retinoblastoma (Rb) is the most common intra-ocular malignancy in children. The association of rs2279744, and rs937283 in MDM2 gene, and p21 rs1801270 polymorphism and RB development have been demonstrated. To provide a comprehensive assessment of and to clarify associations between the 3 SNPs (MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270) and the risk of RB, we performed a meta-analysis of all the eligible case-control studies. Read More

View Article
December 2018

Student acceptance of e-learning methods in the laboratory class in Optometry.

PLoS One 2018 13;13(12):e0209004. Epub 2018 Dec 13.

School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.

Today's students have increased expectations for flexible learning options and evidence-based practice resources to be available to support curricular activities. We investigated: (i) the suitability of a static website for teaching ocular anatomy and physiology and an interactive version of the website with quiz and self-assessment activities and (ii) the usefulness of a blended online and in-lab environment to teach in Optometry. We administered a survey to compare responses of optometry students who had access to the interactive website, with those from students from a previous year who used the static version. Read More

View Article
December 2018

Reducing the impact of the impending myopia epidemic in New Zealand.

N Z Med J 2018 Dec 14;131(1487):80-85. Epub 2018 Dec 14.

Ophthalmologist, Gisborne; Senior Lecturer, Dept of Ophthalmology, University of Otago.

Myopia is an eye condition that is increasing around the world, reaching epidemic levels in many countries. It is associated with a higher risk of other ocular diseases including myopic maculopathy and retinal detachment. Historically in New Zealand myopia has existed at a low level, however the environmental changes that have increased myopia internationally will affect New Zealanders too. Read More

View Article
December 2018

Noninvasive biodegradable nanoparticles-in-nanofibers single-dose ocular insert: in vitro, ex vivo and in vivo evaluation.

Nanomedicine (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Nanomaterials Lab, Center of Material Science (CMS), Zewail City of Science & Technology, 6th of October, Giza 12578, Egypt.

Aim: This study involves, for the first time, the development of mucoadhesive biodegradable polymeric-multilayered nanoparticles-in-nanofibers (NPs-in-NFs) matrix as an innovative single-dose noninvasive ocular-insert that could substitute conventional ocular dosage-forms.

Materials & Methods: Azithromycin-loaded poly(lactic-co-glycolic acid) copolymer/pluronic NPs were developed then incorporated into electrospun polyvinylpyrrolidone NFs, and tested for their efficient treatment of ocular bacterial infection.

Results: Release and permeation studies proved the ability of the insert to control drug release over 10 days. Read More

View Article
December 2018

Evaluation of a Single Dose of Azithromycin for Trachoma in Low-Prevalence Communities.

Ophthalmic Epidemiol 2018 Dec 13:1-6. Epub 2018 Dec 13.

a Division of Parasitic Diseases and Malaria , Centers for Disease Control and Prevention , Atlanta , GA , USA.

Purpose: Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is the leading infectious cause of blindness worldwide and is targeted for elimination as a public health problem. We sought to determine whether a one-time azithromycin mass treatment would reduce trachomatous inflammation-follicular (TF) levels below the elimination threshold of 5% in communities with disease prevalence between 5 and 9.9%. Read More

View Article
December 2018

Alagille syndrome: a case report.

Ann Biol Clin (Paris) 2018 Dec;76(6):675-680

Département de biochimie et génétique, CHU Angers, France.

We report the case of an infant hospitalized for neonatal anoxic ischemia in whom the diagnosis of Alagille syndrome (SAG ; MIM # 118450) was suspected in the presence of major cholestasis, cardiac malformations, suggestive facial dysmorphia, and vertebral and ocular abnormalities. This diagnosis was later confirmed by the detection of a heterozygous pathogenic variant in the gene JAG1, i.e. Read More

View Article
December 2018

Gene-based therapeutic tools in the treatment of Cornea Disease.

Curr Gene Ther 2018 Dec 13. Epub 2018 Dec 13.

Tianjin Medical University Eye Hospital, The College of Optometry, Tianjin 300384. China.

Background: As one of the main blinding ocular diseases, corneal blindness results from neovascularization that disrupts the angiogenic privilege of corneal avascularity. Following neovascularization, inflammatory cells are infiltrating into corneal to strengthen corneal injury. How to maintain corneal angiogenic privilege to treat corneal disease has been investigated for decades. Read More

View Article
December 2018

[Corneal deposits in monoclonal gammopathy of undetermined significance. Review of the literature and case report].

Orv Hetil 2018 Sep;159(39):1575-1583

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

To summarize ophthalmological signs of monoclonal gammopathy of undetermined significance (MGUS) and to present a case report. Summary of the literature data and presentation of the history of a 46-year-old female patient. In MGUS, pathological, but non-malignant plasma cells produce abnormal monoclonal immunoglobulin. Read More

View Article
September 2018

Clinical and genetic characterization of an Italian family with slow-channel syndrome.

Neurol Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology, University of Padova, Padova, Italy.

Introduction: The slow-channel congenital myasthenic syndrome (SCCMS) is a postsynaptic form of congenital myasthenic syndromes (CMSs), a clinically heterogeneous group of disorders caused by genetic defects leading to an abnormal signal transmission at the endplate.

Methods: We report clinical and molecular data of a multigenerational family in which the presentation of a progressive proximal-distal weakness with ocular involvement led to a number of different clinical diagnoses.

Results: A comprehensive genetic study which included whole-genome linkage analysis and whole-exome sequencing identified a heterozygous missense substitution (c. Read More

View Article
December 2018

Effects of femtosecond laser-assisted cataract surgery on dry eye.

Exp Ther Med 2018 Dec 15;16(6):5073-5078. Epub 2018 Oct 15.

Department of Ophthalmology, Air Force General Hospital, Beijing 100089, P.R. China.

The aim of this study was to investigate the effect of femtosecond laser-assisted cataract surgery (FLACS) on tear film and ocular surface function. Patients with age-related cataract who underwent phacoemulsification (phaco) in Air Force Aviation Medicine Research Institute Affiliation Hospital from January 2016 to December 2016 were randomly divided into two groups. Patients in experimental group (n=123, 150 eyes) received FLACS, while patients in phaco group (n=110, 150 eyes) underwent conventional coaxial micro-incision phaco and were implanted with foldable intraocular lens (IOL). Read More

View Article
December 2018

Immunotoxin-Induced Ablation of the Intrinsically Photosensitive Retinal Ganglion Cells in Rhesus Monkeys.

Front Neurol 2018 27;9:1000. Epub 2018 Nov 27.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, United States.

Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment. The goal of this study was to develop and validate a targeted ipRGC immunotoxin to ultimately examine the role of ipRGCs in macaque monkeys. An immunotoxin for the macaque melanopsin gene (), consisting of a saporin-conjugated antibody directed at the N-terminus, was prepared in solutions of 0. Read More

View Article
November 2018

In vivo confocal microscopy classification in the diagnosis of meibomian gland dysfunction.

Eye (Lond) 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France.

Aim: Meibomian gland dysfunction (MGD) is one of the most common disorders in ophthalmology. The aim of this study was to evaluate the use of this in vivo confocal microscopy (IVCM)-MGD description to classify patients affected by clinical MGD and measure the correlation with standard clinical criteria and subjective symptoms.

Methods: One hundred eyes of 100 patients suffering from MGD and 15 eyes of normal subjects were included. Read More

View Article
December 2018

The Effects of Intravitreal Ranibizumab, Aflibercept or Dexamethasone Implant Injections on Intraocular Pressure Changes.

Med Sci Monit 2018 Dec 13;24:9019-9025. Epub 2018 Dec 13.

Department of Ophthalmology, Erzincan Mengücek Gazi Education and Research Hospital, Erzincan, Turkey.

BACKGROUND The aim of this study was to compare the alterations in intraocular pressure (IOP) values during the early postoperative period after intravitreal ranibizumab, aflibercept, or dexamethasone implant injections. MATERIAL AND METHODS In this retrospective study, a total of 188 patients were grouped into 3 groups: the ranibizumab group, the aflibercept group, and the dexamethasone group. Ocular axial length (AXL) and anterior chamber depth (ACD) were measured in the pre-injection period. Read More

View Article
December 2018

Effect of Eyelid Hygiene Detergent on Obstructive Meibomian Gland Dysfunction.

J Oleo Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Keio University School of Medicine.

Purpose: To investigate the efficacy of eyelid margin cleansing with lid hygiene detergent in patients with obstructive meibomian gland dysfunction (MGD).

Methods: As a pilot study, we investigated the safety and efficacy of lid hygiene using tap water and/or lid hygiene shampoo in fourteen eyes of 7 normal subjects. All subjects were instructed to cleanse the eyelid margin with tap water and/or lid hygiene shampoo. Read More

View Article
December 2018

Alterations in gut bacterial and fungal microbiomes are associated with bacterial Keratitis, an inflammatory disease of the human eye.

J Biosci 2018 Dec;43(5):835-856

Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy campus, Hyderabad 500 034, India.

Dysbiosis, or imbalance in the gut microbiome, has been implicated in auto-immune, inflammatory, neurological diseases as well as in cancers. More recently it has also been shown to be associated with ocular diseases. In the present study, the association of gut microbiome dysbiosis with bacterial Keratitis, an inflammatory eye disease which significantly contributes to corneal blindness, was investigated. Read More

View Article
December 2018

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Eye Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Serotonin receptor agonists are neuroprotective in central nervous system (CNS) injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-OH-DPAT, a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas, as the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas, and 8-OH-DPAT enhanced the RGC viability. Read More

View Article
December 2018

Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries.

J Immunol 2018 Dec 12. Epub 2018 Dec 12.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114.

Reactive microglia and infiltrating peripheral monocytes have been implicated in many neurodegenerative diseases of the retina and CNS. However, their specific contribution in retinal degeneration remains unclear. We recently showed that peripheral monocytes that infiltrate the retina after ocular injury in mice become permanently engrafted into the tissue, establishing a proinflammatory phenotype that promotes neurodegeneration. Read More

View Article
December 2018

The Gaze Stabilization Test Following Concussion.

J Am Acad Audiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA.

Background: Concussion can cause vestibular dysfunction and oculomotor abnormalities which can lead to dizziness and protracted recovery time. There are few clinically useful, functional measures of the vestibulo-ocular reflex (VOR) post-concussion.

Purpose: The purpose of this study was to examine the gaze stabilization test (GST) in those referred for vestibular physical therapy following concussion, to determine the association between GST and other measures of recovery following concussion, and to examine the effect of demographic variables on GST performance. Read More

View Article
November 2018

Proton beam therapy for cancer in the era of precision medicine.

J Hematol Oncol 2018 Dec 12;11(1):136. Epub 2018 Dec 12.

Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.

Precision radiotherapy, which accurately delivers the dose on a tumor and confers little or no irradiation to the surrounding normal tissue and organs, results in maximum tumor control and decreases the toxicity to the utmost extent. Proton beam therapy (PBT) provides superior dose distributions and has a dosimetric advantage over photon beam therapy. Initially, the clinical practice and study of proton beam therapy focused on ocular tumor, skull base, paraspinal tumors (chondrosarcoma and chordoma), and unresectable sarcomas, which responded poorly when treated with photon radiotherapy. Read More

View Article
December 2018

Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma.

BMC Ophthalmol 2018 Dec 12;18(1):320. Epub 2018 Dec 12.

Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA.

Background: To describe the superiority of ocular ultrasound in the diagnostic management of extrascleral extension in choroidal melanoma.

Case Presentation: We present a case of a 94-year-old male with choroidal melanoma of the right eye imaged with MRI and ocular ultrasound to aid in the detection of extrascleral extension.

Conclusions: With advancement in technology and new imaging modalities emerging, it can become difficult to determine the best diagnostic approach for patients. Read More

View Article
December 2018

Xerosis in Patient with Vitamin A Deficiency - a Case Report.

Cesk Slov Oftalmol 2018 ;73(5-6):222-224

Xerosis is a corneal and ocular surface disease caused by vitamin A deficiency. It is a rare disease in developed countries, but in third world countries it is a common cause of blindness. We describe a typical xerosis in patient with vitamin A deficiency and long-term malnutrition and alcoholism in our case. Read More

View Article
January 2018

The treatment results in patients with lmphoma disease in the orbit.

Cesk Slov Oftalmol 2018 ;73(5-6):211-217

Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkins lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Read More

View Article
January 2018

Sarkoidosis and its Eye Ocular Manifestation (an Analysis of Six Case Report).

Cesk Slov Oftalmol 2018 ;73(5-6):189-197

Aim: To introduce the range of eye changes in sarcoidosis in the individual casuistics.

Materials: At the Ophthalmic Clinic of Teaching Hospital Královské Vinohrady in Prague were examined and treated six patients with ocular forms of sarcoidosis in the years from 1998 to 2015. Three patients were unilateral lesions of the lacrimal gland without systemic symptoms. Read More

View Article
January 2018

Pegylated Interferon-Induced Sarcoidosis Presenting With Anterior Uveitis in a Patient with Chronic Hepatitis C - Case Report.

Curr Health Sci J 2015 Oct-Dec;41(4):379-384. Epub 2015 Dec 22.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Sarcoidosis is a chronic inflammatory systemic disorder of unknown etiology. It is known to be triggered by an autoimmune process, and is currently recognized as a rare adverse event to interferon therapy for Hepatitis C Virus Infection. Clinical presentation of interferon-triggered sarcoidosis is varied, but ocular manifestation as a first symptom was only once, previously reported. Read More

View Article
December 2015

Low-dose brimonidine for relief of ocular redness: integrated analysis of four clinical trials.

Clin Exp Optom 2018 Dec 7. Epub 2018 Dec 7.

Clinical Affairs, Bausch + Lomb, Bridgewater, New Jersey, USA.

Background: The aim of this study was to provide an integrated analysis of safety and efficacy data for brimonidine tartrate ophthalmic solution 0.025 per cent (low-dose; Bausch & Lomb Incorporated), a topical vasoconstrictor for relief of ocular redness.

Methods: Integrated efficacy data from two randomised, double-masked, vehicle-controlled studies in subjects with ocular redness as well as safety data from the two efficacy studies, a vehicle-controlled safety study, and a pharmacokinetic study were analysed. Read More

View Article
December 2018

Transforming growth factor-β blocks glucose-induced inflammation and apoptosis in corneal epithelial cells.

FEBS Open Bio 2018 Dec 6;8(12):1936-1942. Epub 2018 Nov 6.

Department of Ophthalmology Zoucheng People's Hospital China.

Diabetic retinopathy is the most important ocular complication associated with diabetes. Corneal defects due to diabetes mellitus (DM) may cause severe vision impairments. This study aimed to identify the effect of transforming growth factor-β (TGF-β) on biological events, such as apoptosis and inflammation, in the diabetic cornea. Read More

View Article
December 2018

Computed Tomography Angiography of Bilateral Intracavernous Internal Carotid Artery Aneurysms.

Neuroophthalmology 2018 Dec 26;42(6):404-405. Epub 2018 Mar 26.

Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Bilateral intracavernous internal carotid artery aneurysms are rare. They are more common in elderly females and are associated with hypertension. We present the computed tomography angiography findings of an 81-year-old female with history of hypertension who came complaining of diplopia and headache. Read More

View Article
December 2018

Photo Essay: Retinal Changes in Type 3 Gaucher Disease.

Neuroophthalmology 2018 Dec 5;42(6):402-403. Epub 2018 Feb 5.

Department of Haematology, Royal Free London Hospitals NHS Foundation Trust, London, UK.

Ocular features of Gaucher disease include gaze abnormalities, corneal clouding, ocular deposits and pigmentary changes in the macula. We report the presence of bilateral fovea sparing macular deposits in a 21-year-old woman with type 3 Gaucher disease. Macular deposits occur due to glucocerebroside accumulation within histiocytes and retinal deposits might correlate with the degree of systemic infiltration. Read More

View Article
December 2018

A Stereotyped Syndrome with Retro-Ocular Pain, Photophobia, and Visual Disturbance Masquerading as Optic Neuritis: Case Series.

Neuroophthalmology 2018 Dec 15;42(6):339-342. Epub 2018 Aug 15.

Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.

We describe here a case series of six patients referred to the Neuro-ophthalmology service in Sheffield, UK with possible acute unilateral optic neuritis. Each patient had a triad of unilateral photophobia, ipsilateral retro-ocular pain, and ipsilateral loss of vision. All patients had normal ocular examinations and investigation findings with no objective structural or functional abnormalities identified. Read More

View Article
December 2018

Past and Present of Eye Movement Abnormalities in Ataxia-Telangiectasia.

Cerebellum 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurology, Neurology Service, Cleveland VA Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA.

Ataxia-telangiectasia is the second most common autosomal recessive hereditary ataxia, with an estimated incidence of 1 in 100,000 births. Besides ataxia and ocular telangiectasias, eye movement abnormalities have long been associated with this disorder and is frequently present in almost all patients. A handful of studies have described the phenomenology of ocular motor deficits in ataxia-telangiectasia. Read More

View Article
December 2018

Demographic characteristics and visual outcomes of open globe injuries in a tertiary hospital in Istanbul, Turkey.

Eur J Trauma Emerg Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Halaskargazi Cad. Etfal Sk, Sisli, 34371, Istanbul, Turkey.

Purpose: To evaluate the demographic characteristics and visual outcomes of patients with open globe injury (OGI) in a tertiary hospital in Istanbul, Turkey.

Methods: The data of patients admitted with OGI to Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey from January 2012 to December 2017 were reviewed retrospectively, and 100 of the 154 patients were included in the study.

Results: There were 79 (79%) male and 21 (21%) female patients with the average age of 33. Read More

View Article
December 2018

[Law of dominant eye's transformation after cataract phacoemulsification and intraocular lens implantation surgery].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1103-1111

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To study the change of the dominant eye in the age-related cataract patients before and after surgery, to analyze the correlation between the orientation of the dominant eye and the visual quality, and to observe whether the patients with the change in dominant eye were converted to dizziness.
 Methods: A total of 44 patients, with age-related cataract between 60 and 80 years old were enrolled. Group A: the non-dominant (secondary) eye served as the surgical eye (n=35); Group B: the dominant eye served as the surgical eye (n=9); Group C: the operation was performed on the contralateral eye after a month (n=28). Read More

View Article
October 2018

[The Basic Modules of the Neocortex].

Brain Nerve 2018 Dec;70(12):1381-1388

Laboratory for Local Neuronal Circuits, RIKEN Center for Brain Science.

The mammalian neocortex contains diverse cell types but whether they organize into repeated modular circuits remains unknown. We discovered that major cell types in neocortical layer 5 form a lattice structure in many areas of the brain. Large-scale three-dimensional imaging revealed that distinct types of excitatory and inhibitory neurons form cell type-specific radial clusters termed microcolumns. Read More

View Article
December 2018

Combination of multimodal imaging features predictive of choroidal nevus transformation into melanoma.

Br J Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Aim: To characterise combinations of multimodal imaging risk factors and predictive value for choroidal nevus transformation into melanoma.

Methods: This is a retrospective review of multimodal imaging features for 3806 choroidal nevi from 1 January 2007 through 1 January 2017. Kaplan-Meier estimates and Cox regression analyses were used to calculate 5-year percentages of growth to melanoma and HR. Read More

View Article
December 2018

Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

View Article
December 2018
2 Reads

The transfer function of the rhesus macaque oculomotor system for small-amplitude slow motion trajectories.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Werner Reichardt Centre for Integrative Neuroscience, Germany.

Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well-studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Read More

View Article
December 2018

Long-term Evaluation of Corneal Biomechanical Properties After Corneal Cross-linking for Keratoconus: A 4-Year Longitudinal Study.

J Refract Surg 2018 Dec;34(12):849-856

Purpose: To compare the long-term changes in corneal biomechanics, topography, and tomography before and 4 years after corneal cross-linking (CXL) with the Dresden protocol and correlate these changes with visual acuity.

Methods: In this longitudinal study, 18 eyes of 18 patients with progressive keratoconus who were treated with CXL were included. All patients received a standard ophthalmological examination and were examined by Placido disc-based topography, Scheimpflug tomography, and biomechanical assessments with the Corvis ST (OCULUS Optikgeräte GmbH, Wetzlar, Germany) and Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Buffalo, NY) before and 4 years after CXL. Read More

View Article
December 2018

Using intracameral vital dye as a guide for venting incision in acute corneal hydrops.

Eur J Ophthalmol 2018 Dec 12:1120672118818012. Epub 2018 Dec 12.

Ocular Trauma and Emergency Department and Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose:: To introduce a new surgical technique for the localization of corneal bulla to drain a massive corneal hydrops.

Methods:: Four consecutive cases with acute large protruded hydrops were selected. A limbal paracentesis was made via 15° blade. Read More

View Article
December 2018
1 Read

Assessing photoreceptor structure in patients with traumatic head injury.

BMJ Open Ophthalmol 2018 24;3(1):e000104. Epub 2018 Nov 24.

Department of Ophthalmology and Visual Sciences, University of WI - Madison, Madison, Wisconsin, USA.

Objective: Previous work using adaptive optics scanning light ophthalmoscopy (AOSLO) imaging has shown photoreceptor disruption to be a common finding in head and ocular trauma patients. Here an expanded trauma population was examined using a novel imaging technique, split-detector AOSLO, to assess remnant cone structure in areas with significant disruption on confocal AOSLO imaging and to follow photoreceptor changes longitudinally.

Methods And Analysis: Eight eyes from seven subjects with head and/or ocular trauma underwent imaging with spectral domain optical coherence tomography, confocal AOSLO and split-detector AOSLO to assess foveal and parafoveal photoreceptor structure. Read More

View Article
November 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

View Article
November 2018
1 Read

Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study.

Clin Ophthalmol 2018 26;12:2399-2407. Epub 2018 Nov 26.

Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France.

Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.

Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.

Methods: This was an international, prospective, and observational real-life study. Read More

View Article
November 2018